Aliases for SDHB Gene
External Ids for SDHB Gene
Previous Symbols for SDHB Gene
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for SDHB Gene
SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip)) is a Protein Coding gene. Diseases associated with SDHB include paragangliomas 4 and cowden syndrome 2. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and 2 iron, 2 sulfur cluster binding.
UniProtKB/Swiss-Prot for SDHB Gene
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)