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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SDHAF2 Gene

protein-coding   GIFtS: 57
GCID: GC11P061198

Succinate Dehydrogenase Complex Assembly Factor 2

(Previous names: paraganglioma or familial glomus tumors 2, chromosome 11...)
(Previous symbols: PGL2, C11orf79)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Succinate Dehydrogenase Complex Assembly Factor 21 2     hSDH52 3
PGL21 2 3 5     SDH Assembly Factor 22 3
C11orf791 2 3     Chromosome 11 Open Reading Frame 791
SDH52 3 5     Paraganglioma Or Familial Glomus Tumors 21
Succinate Dehydrogenase Subunit 5, Mitochondrial2 3     Succinate Dehydrogenase Assembly Factor 2, Mitochondrial2

External Ids:    HGNC: 260341   Entrez Gene: 549492   Ensembl: ENSG000001679857   OMIM: 6130195   UniProtKB: Q9NX183   

Export aliases for SDHAF2 gene to outside databases

Previous GC identifers: GC11P060956 GC11P057525


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SDHAF2 Gene:
This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit
required for activity of the complex. Mutations in this gene are associated with paraganglioma.(provided by
RefSeq, Jul 2010)

GeneCards Summary for SDHAF2 Gene: 
SDHAF2 (succinate dehydrogenase complex assembly factor 2) is a protein-coding gene. Diseases associated with SDHAF2 include paraganglioma, and hereditary paraganglioma-pheochromocytoma syndromes. GO annotations related to this gene include protein binding. An important paralog of this gene is ENSG00000256591.

UniProtKB/Swiss-Prot: SDHF2_HUMAN, Q9NX18
Function: Required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase
(SDH). SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for
transferring electrons from succinate to ubiquinone (coenzyme Q). In is unclear whether it participates in the
chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDHA in a conformation
that is susceptible to autocatalytic FAD attachment




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SDHAF2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSDHAF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SDHAF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDHAF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

SDHAF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDHAF2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P061198:  view genomic region     (about GC identifiers)

Start:
61,197,514 bp from pter      End:
61,215,001 bp from pter
Size:
17,488 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SDHF2_HUMAN, Q9NX18 (See protein sequence)
Recommended Name: Succinate dehydrogenase assembly factor 2, mitochondrial precursor  
Size: 166 amino acids; 19599 Da
Subunit: Interacts with SDHA
Subcellular location: Mitochondrion

Explore the universe of human proteins at neXtProt for SDHAF2: NX_Q9NX18

Explore proteomics data for SDHAF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NX18

  • SDHAF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SDHAF2 Protein Expression
    REFSEQ proteins: NP_060311.1  
    ENSEMBL proteins: 
     ENSP00000439983   ENSP00000301761   ENSP00000469670   ENSP00000471030   ENSP00000352630  
     ENSP00000469951   ENSP00000471120   ENSP00000443660  

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    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for SDHAF2
    Cloud-Clone Corp. Proteins for SDHAF2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    SDHAF2 for ontologies           About GeneDecksing



    SDHAF2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MITOAF: Mitochondrial respiratory chain complex assembly factors

    1 InterPro protein domain:
     IPR005631 DUF339

    Graphical View of Domain Structure for InterPro Entry Q9NX18

    ProtoNet protein and cluster: Q9NX18

    1 Blocks protein domain: IPB005631 Protein of unknown function DUF339

    UniProtKB/Swiss-Prot: SDHF2_HUMAN, Q9NX18
    Similarity: Belongs to the SDHAF2 family


    SDHAF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SDHF2_HUMAN, Q9NX18
    Function: Required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase
    (SDH). SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for
    transferring electrons from succinate to ubiquinone (coenzyme Q). In is unclear whether it participates in the
    chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDHA in a conformation
    that is susceptible to autocatalytic FAD attachment

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19628817
         
    SDHAF2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SDHAF2 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SDHAF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/11 Interacting proteins for SDHAF2 (Q9NX182, 3 ENSP000003017614) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IMMTQ168912, 3, ENSP000003872624MINT-65652 I2D: score=5 STRING: ENSP00000387262
    CCDC90BQ9GZT62, 3MINT-65655 I2D: score=5 
    IKBKAPO951633I2D: score=5 
    EEF1A1P681043I2D: score=4 
    SDHAENSP000002649324STRING: ENSP00000264932
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006121mitochondrial electron transport, succinate to ubiquinone IMP19628817
    GO:0018293protein-FAD linkage IMP19628817

    SDHAF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SDHAF2 (SDHF2)

    Search CenterWatch for drugs/clinical trials and news about SDHAF2 / SDHF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SDHAF2 gene: 
    NM_017841.2  

    Unigene Cluster for SDHAF2:

    Succinate dehydrogenase complex assembly factor 2
    Hs.313247  [show with all ESTs]
    Unigene Representative Sequence: BX648946
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000542794 ENST00000301761(uc001nrt.3) ENST00000542074 ENST00000534878
    ENST00000359614 ENST00000537782 ENST00000536250 ENST00000543265
    miRNA
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    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDHAF2
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    Additional mRNA sequence: 

    AK000494.1 BC002331.2 BX648946.1 

    17 DOTS entries:

    DT.443663  DT.100852617  DT.91752889  DT.100671343  DT.91752895  DT.100642256  DT.100671345  DT.120729019 
    DT.86855819  DT.95158562  DT.100671344  DT.451998  DT.120728921  DT.95099589  DT.95158565  DT.95323629 
    DT.120728969 

    24/353 AceView cDNA sequences (see all 353):

    CR593424 BM674145 BM835761 BI906708 BM717282 CF127815 BM677487 AW167134 
    BX375067 BM714098 BC043246 BM723033 AW966421 AA383792 AA741260 BQ057931 
    BM847621 AI285205 AI289928 AA907871 AW338664 CR616531 AA910615 AA913273 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SDHAF2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
    SP1:                                      -     -     -                                             
    SP2:                    -                 -                                                         
    SP3:                    -                 -     -                                                   
    SP4:                    -                 -     -     -                                             
    SP5:                                -     -     -     -                                             


    ECgene alternative splicing isoforms for SDHAF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SDHAF2 expression in normal human tissues (normalized intensities)      SDHAF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGCTTTGC
    SDHAF2 Expression
    About this image


    SDHAF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See SDHAF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SDHAF2

    SOURCE GeneReport for Unigene cluster: Hs.313247
        SABiosciences Custom PCR Arrays for SDHAF2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDHAF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SDHAF2 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sdhaf21 , 5 succinate dehydrogenase complex assembly factor 21, 5 89.78(n)1
    92.02(a)1
      19 (6.60 cM)5
    660721  NM_025333.41  NP_079609.21 
     105005135 
    chicken
    (Gallus gallus)
    Aves LOC4260151 succinate dehydrogenase assembly factor 2, mitochondrial-like 67.32(n)
    70.78(a)
      426015  XM_423694.3  XP_423694.3 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj30e042 Transcribed sequence with weak similarity to protein more 73.41(n)    57074250 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG147571 CG14757 55.35(n)
    55.96(a)
      35797  NM_136519.1  NP_610363.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y57A10A.296
    Succinate dehydrogenase assembly factor 2, mitocho...
    37(a)
    1 → many
    II(12277581-12280283)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EMI5(YOL071W)4 Subunit of succinate dehydrogenase, which couples succinate more   --   15(196507-196995) 854083  NP_014570.1 


    ENSEMBL Gene Tree for SDHAF2 (if available)
    TreeFam Gene Tree for SDHAF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SDHAF2 gene
    ENSG000002565912  

    SDHAF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/394 SNPs in SDHAF2 are shown (see all 394)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0587054
    Paragangliomas 2 (PGL2)4--see VAR_0587052 G R mis40--------
    rs1135603201,2
    Cpathogenic161125694(+) AGAGGA/GGAATG 2 R G mis10--------
    rs801234121,2
    C,F--61116037(+) GCATGG/TAAGAT 1 -- us2k11Minor allele frequency- T:0.12EA 120
    rs1159432861,2
    F--61116048(+) TATTTC/ATTTGA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1840695311,2
    --61116164(+) GGGAGA/TACCTC 1 -- us2k10--------
    rs1996833781,2
    --61116228(+) TGTTG-/TTTTTT 1 -- us2k10--------
    rs1889937921,2
    --61116417(+) ACTGAG/TGGTAT 1 -- us2k10--------
    rs1498870861,2
    --61116454(+) AACTGC/GTTTGT 1 -- us2k10--------
    rs1441321061,2
    C--61116523(+) TTATAA/CCAAAA 1 -- us2k10--------
    rs1924370181,2
    --61116623(+) CATCTA/TTTCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SDHAF2 (61197514 - 61215001 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SDHAF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897603CNV Loss21882294
    nsv832178CNV Gain+Loss17160897


    Human Gene Mutation Database (HGMD): SDHAF2

    Locus Specific Mutation Databases (LSDB): SDHAF2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SDHAF2
    DNA2.0 Custom Variant and Variant Library Synthesis for SDHAF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613019   
    OMIM disorders: 601650  
    UniProtKB/Swiss-Prot: SDHF2_HUMAN, Q9NX18
  • Paragangliomas 2 (PGL2) [MIM:601650]: A neural crest tumor usually derived from the chromoreceptor tissue
    of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and
    abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation,
    the jugular foramen, the vagal nerve, and in the middle ear. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 10 diseases for SDHAF2:    About MalaCards
    paraganglioma    hereditary paraganglioma-pheochromocytoma syndromes    paragangliomas 2    glomus tumor
    neural crest tumor    phaeochromocytoma    pheochromocytoma    hemangioblastoma
    neuroendocrine tumor    hemangioma

    2 diseases from the University of Copenhagen DISEASES database for SDHAF2:
    Paraganglioma     Hemangioma

    SDHAF2 for disorders           About GeneDecksing

    GeneTests: SDHAF2
    GeneReviews: SDHAF2
    Genetic Association Database (GAD): SDHAF2
    Human Genome Epidemiology (HuGE) Navigator: SDHAF2 (2 documents)

    Export disorders for SDHAF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SDHAF2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SDHAF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. (PubMed id 19628817)1, 2, 3 Hao H.-X.... Rutter J. (2009)
    2. The role of complex II in disease. (PubMed id 23174333)1 Hoekstra A.S. and Bayley J.P. (2013)
    3. Mitochondrial complex II and genomic imprinting in inh eritance of paraganglioma tumors. (PubMed id 23291190)1 Baysal B.E. (2013)
    4. Emerging concepts in the flavinylation of succinate de hydrogenase. (PubMed id 23380393)1 Kim H.J. and Winge D.R. (2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. SDHAF2 (PGL2-SDH5) and hereditary head and neck parag anglioma. (PubMed id 21224366)1 Kunst H.P....Cremers C.W. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Isocitrate dehydrogenase mutations are rare in pheoch romocytomas and paragangliomas. (PubMed id 19915015)1 Gaal J....Dinjens W.N. (2010)
    10. Expression and somatic mutations of SDHAF2 (SDH5), a novel endocrine tumor suppressor gene in parathyroid tumors of primary hyperpar athyroidism. (PubMed id 20972721)1 Starker L.F....Carling T. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54949 HGNC: 26034 AceView: FLJ20487andFLJ32771 Ensembl:ENSG00000167985 euGenes: HUgn54949
    ECgene: SDHAF2 H-InvDB: SDHAF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SDHAF2 Pharmacogenomics, SNPs, Pathways
    TCA Cycle Gene Mutation Databasehttp://chromium.liacs.nl/LOVD2/SDH/home.php?select_db=SDHAF2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SDHAF2 gene:
    Search GeneIP for patents involving SDHAF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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