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SDF4 Gene

protein-coding   GIFtS: 55
GCID: GC01M001152

Stromal Cell Derived Factor 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Stromal Cell Derived Factor 41 2     Calcium Binding Protein1
Cab452 3     45 KDa Calcium-Binding Protein2
SDF-42 3     Stromal Cell-Derived Factor 43
CAB453 5     

External Ids:    HGNC: 241881   Entrez Gene: 511502   Ensembl: ENSG000000788087   OMIM: 6142825   UniProtKB: Q9BRK53   

Export aliases for SDF4 gene to outside databases

Previous GC identifers: GC01M001181 GC01M001143 GC01M000423


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SDF4 Gene:
This gene encodes a stromal cell derived factor that is a member of the CREC protein family. The encoded protein
contains six EF-hand motifs and calcium-binding motifs. This protein localizes to the Golgi lumen and may be
involved in regulating calcium dependent cellular activities. (provided by RefSeq, Sep 2011)

GeneCards Summary for SDF4 Gene:
SDF4 (stromal cell derived factor 4) is a protein-coding gene. GO annotations related to this gene include identical protein binding and calcium ion binding. An important paralog of this gene is RCN3.

UniProtKB/Swiss-Prot: CAB45_HUMAN, Q9BRK5
Function: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment (By
similarity)
Function: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini

Gene Wiki entry for SDF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the SDF4 gene promoter:
         AML1a   GCNF   Bach2   RelA   MIF-1   NF-kappaB   GCNF-1   GCNF-2   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSDF4 promoter sequence
   Search Chromatin IP Primers for SDF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SDF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

SDF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDF4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001152:  view genomic region     (about GC identifiers)

Start:
1,152,288 bp from pter      End:
1,167,447 bp from pter
Size:
15,160 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAB45_HUMAN, Q9BRK5 (See protein sequence)
Recommended Name: 45 kDa calcium-binding protein precursor  
Size: 362 amino acids; 41807 Da
Subunit: Isoform 5 interacts with STXBP1; the interaction is enhanced in presence of calcium. Isoform 5 interacts
with STX3
Sequence caution: Sequence=AAL75950.1; Type=Frameshift; Positions=Several;
Secondary accessions: B1AME5 B1AME6 B2RDF1 B4DSM1 Q53G52 Q53HQ9 Q8NBQ3 Q96AA1 Q9NZP7 Q9UN53
Alternative splicing: 6 isoforms:  Q9BRK5-1   Q9BRK5-2   Q9BRK5-3   Q9BRK5-4   Q9BRK5-5   Q9BRK5-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SDF4: NX_Q9BRK5

Explore proteomics data for SDF4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys85, Lys350
  • Glycosylation2 at Asn40, Ser108, Ser343, Thr347, Ser349, Ser357
  • Modification sites at PhosphoSitePlus

  • See SDF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_057260.2  NP_057631.1  

    ENSEMBL proteins: 
     ENSP00000353094   ENSP00000435962   ENSP00000263741   ENSP00000384207   ENSP00000444451  

    SDF4 Human Recombinant Protein Products:

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    Novus Biologicals SDF4 Protein
    Novus Biologicals SDF4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SDF4

     
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    Search eBioscience for ELISAs for SDF4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS
     IPR027240 CAB45

    Graphical View of Domain Structure for InterPro Entry Q9BRK5

    ProtoNet protein and cluster: Q9BRK5

    UniProtKB/Swiss-Prot: CAB45_HUMAN, Q9BRK5
    Domain: Binds calcium via its EF-hands (By similarity). Isoform 5 binds calcium
    Similarity: Belongs to the CREC family
    Similarity: Contains 6 EF-hand domains


    Find genes that share domains with SDF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAB45_HUMAN, Q9BRK5
    Function: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment (By
    similarity)
    Function: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding ISS--
    GO:0005515protein binding IPI17442889
    GO:0042802identical protein binding ISS17442889
         
    Find genes that share ontologies with SDF4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SDF4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SDF4
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    miRNA
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    hsa-mir-378a-5p (MIRT043980), hsa-mir-484 (MIRT042088)

    Block miRNA regulation of human, mouse, rat SDF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SDF4 (see all 15):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-4328 hsa-miR-548k hsa-miR-548c-5p
    SwitchGear 3'UTR luciferase reporter plasmidSDF4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SDF4

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SDF4 (NM_016547)
    Sino Biological Human cDNA Clone for SDF4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDF4

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SDF4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDF4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAB45_HUMAN, Q9BRK5: Isoform 1: Golgi apparatus lumen (By similarity)
    CAB45_HUMAN, Q9BRK5: Isoform 5: Cytoplasm. Cell projection, bleb. Note=Isoform 5 colocalizes with STX3 and STXBP1
    isoform 2 at the plasma membrane and cell surface blebs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome3
    golgi apparatus3
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    extracellular2
    nucleus2
    plasma membrane2
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS17442889
    GO:0005770late endosome ISS--
    GO:0005794Golgi apparatus IDA--
    GO:0005796Golgi lumen ISS--
    GO:0005886colocalizes with plasma membrane ISS17442889

    Find genes that share ontologies with SDF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SDF4
    Interactions:

        Search GeneGlobe Interaction Network for SDF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SDF4 (Q9BRK52, 3 ENSP000003530944) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271487 I2D: score=2 
    SMN2Q166372, 3MINT-8271487 I2D: score=2 
    ANXA7P200732, 3MINT-8248691 I2D: score=2 
    CDKN1AP389362, 3MINT-8252223 I2D: score=2 
    RAP1BP612242, 3MINT-8268141 I2D: score=2 
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009650UV protection ISS18355758
    GO:0017156calcium ion-dependent exocytosis ISS17442889
    GO:0021549cerebellum development ISS18355758
    GO:0045444fat cell differentiation ISS--
    GO:0045471response to ethanol ISS18355758

    Find genes that share ontologies with SDF4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SDF4 (CAB45)

    1 HMDB Compound for SDF4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SDF4 gene (2 alternative transcripts): 
    NM_016176.3  NM_016547.2  

    Unigene Cluster for SDF4:

    Stromal cell derived factor 4
    Hs.42806  [show with all ESTs]
    Unigene Representative Sequence: NM_016547
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360001 ENST00000465727(uc009vjw.3) ENST00000263741(uc001adh.4 uc001adi.4)
    ENST00000494748(uc001adg.3) ENST00000478938 ENST00000403997(uc001adj.1)
    ENST00000459994 ENST00000545427
    miRNA
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    Block miRNA regulation of human, mouse, rat SDF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SDF4 (see all 15):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-4328 hsa-miR-548k hsa-miR-548c-5p
    SwitchGear 3'UTR luciferase reporter plasmidSDF4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SDF4
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SDF4 (NM_016547)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDF4
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SDF4
      QuantiTect SYBR Green Assays in human, mouse, rat SDF4
      QuantiFast Probe-based Assays in human, mouse, rat SDF4

    Additional mRNA sequence: 

    AF132749.1 AF178986.1 AK027277.1 AK075352.1 AK222521.1 AK223079.1 AK299810.1 AK315517.1 
    BC006211.2 BC007625.1 BC008917.2 BC011244.1 BC022375.1 L79912.1 

    Selected DOTS entries (see all 26):

    DT.40246297  DT.455498  DT.100882818  DT.100882801  DT.97817978  DT.100882820  DT.100882809  DT.100035016 
    DT.100800726  DT.95343881  DT.100882795  DT.121384106  DT.121384119  DT.92464350  DT.121384121  DT.100882837 
    DT.95343840  DT.100882826  DT.100882832  DT.121384169  DT.95343780  DT.95343781  DT.95343797  DT.95343814 

    Selected AceView cDNA sequences (see all 911):

    BM973867 AI452903 L79912 BQ774579 BF312948 BU617874 BF725325 CR612360 
    BM826186 BM836617 BU931692 CF132294 BU621366 BU630200 CR597574 BQ961889 
    CA425490 AW470118 CA437071 BU623193 BQ574237 BQ008525 CA748620 BU633012 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SDF4 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:                                      -                 -                                             
    SP2:                                      -                 -     -                                       
    SP3:                                      -                 -     -                 -     -               
    SP4:                    -     -           -                 -     -                 -     -               
    SP5:                                                        -     -                 -     -               


    ECgene alternative splicing isoforms for SDF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SDF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACGAGTACA
    SDF4 Expression
    About this image


    SDF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    SDF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SDF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.42806

    UniProtKB/Swiss-Prot: CAB45_HUMAN, Q9BRK5
    Tissue specificity: Ubiquitous. Isoform 5 is expressed in pancreas

        Custom PCR Arrays for SDF4
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    QuantiTect SYBR Green Assays in human, mouse, rat SDF4
    QuantiFast Probe-based Assays in human, mouse, rat SDF4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SDF4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sdf41 , 5 stromal cell derived factor 41, 5 83.01(n)1
    87.26(a)1
      4 (87.66 cM)5
    203181  NM_011341.41  NP_035471.11 
     1559928725 
    chicken
    (Gallus gallus)
    Aves SDF41 stromal cell derived factor 4 73.21(n)
    80.97(a)
      419423  NM_001006302.1  NP_001006302.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.64902 Xenopus laevis transcribed sequence with weak similarity more 75.75(n)    BX854773.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb66d062 Danio rerio mRNA similar to stromal cell derived factor more 77.93(n)    BC049332.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG314751 CG31475 48.63(n)
    35.69(a)
      42303  NM_001275796.1  NP_001262725.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C56C10.91 C56C10.9 43.94(n)
    30.87(a)
      183859  NM_062937.5  NP_495338.1 


    ENSEMBL Gene Tree for SDF4 (if available)
    TreeFam Gene Tree for SDF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SDF4 gene
    RCN32  RCN12  CALU2  RCN22  

    Find genes that share paralogs with SDF4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SDF4 (see all 635)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354614
    A colorectal cancer sample4--see VAR_0354612 A T mis40--------
    rs784799121,2
    C,F--423615(+) ACAGAG/ACAGGA 2 -- ds50013Minor allele frequency- A:0.03WA NA EA 358
    rs759721221,2
    C,F--423671(+) GGCTAG/CGCCTG 2 -- ds50015Minor allele frequency- C:0.23CSA WA NA EA 362
    rs1468614101,2
    --423773(+) GGGCAC/TGTCTG 2 -- ds50010--------
    rs767982881,2
    C,F--423778(+) CGTCTG/CCTGCC 2 -- ds50012Minor allele frequency- C:0.07NA EA 240
    rs2009406171,2
    --423782(+) TGCTG-/CCCCCT 2 -- ds50010--------
    rs2019442771,2
    C--423786(+) GCCCC-/CTGACCC 2 -- ds50010--------
    rs1118189131,2
    C--423787(+) CCCCCT/-GACCC 2 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs771237801,2
    F--423952(+) TAGCAC/TGCTGC 2 -- ds50010--------
    rs1401900471,2
    C--423970(+) TTTTG-/TTTCAC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SDF4 (1152288 - 1167447 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SDF4 (see all 39):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745030CNV Deletion23290073
    esv2745141CNV Deletion23290073
    esv2745252CNV Deletion23290073
    dgv24n71CNV Loss21882294
    nsv470680CNV Loss18288195
    nsv871680CNV Loss21882294
    nsv482937CNV Loss15286789
    dgv12n71CNV Loss21882294
    dgv25n71CNV Loss21882294
    dgv21n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614282    OMIM disorders: --


    Find genes that share disorders with SDF4           About GenesLikeMe

    Genetic Association Database (GAD): SDF4
    Human Genome Epidemiology (HuGE) Navigator: SDF4 (4 documents)

    Export disorders for SDF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SDF4 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with SDF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of a human cDNA encoding Cab45, a Ca2+-binding protein with six EF-hand motifs. (PubMed id 9254016)1, 2, 3 Koivu T.... Olkkonen V.M. (DNA Seq. 1997)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    4. A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. (PubMed id 17442889)1, 2 Lam P.P.... Olkkonen V.M. (Mol. Biol. Cell 2007)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Cab45, a novel (Ca2+)-binding protein localized to the Golgi lumen. (PubMed id 8609160)1, 3 Scherer P.E....Lodish H.F. (J. Cell Biol. 1996)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51150 HGNC: 24188 AceView: Cab45 Ensembl:ENSG00000078808 euGenes: HUgn51150
    ECgene: SDF4 H-InvDB: SDF4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SDF4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SDF4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SDF4 gene:
    Search GeneIP for patents involving SDF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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