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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SDF2L1 Gene

protein-coding GIFtS: 50
GCID: GC22P021996

stromal cell-derived factor 2-like 1

Explore 3 diseases affiliated with
SDF2L1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Stromal Cell-Derived Factor 2-Like 1¹ ²		AP000553.C22.4¹
OTTHUMT00000075032¹ ²		Dihydropyrimidinase-Like 2²
PWP1-Interacting Protein 8² ³		SDF2-Like 1²
SDF2-Like Protein 1² ³		Stromal Cell-Derived Factor 2-Like Protein 1²

External Ids:	HGNC: 10676¹	Entrez Gene: 23753²	Ensembl: ENSG00000128228⁷	OMIM: 607551⁵	UniProtKB: Q9HCN8³

Export aliases for SDF2L1 gene to outside databases

Previous GC identifers: GC22P018695 GC22P020320 GC22P020321 GC22P004954

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SDF2L1 gene promoter:
Pax-5 SREBP-1c Brachyury SREBP-1b E47 YY1 GATA-1 MEF-2A SREBP-1a aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SDF2L1 promoter sequence

Search SABiosciences Chromatin IP Primers for SDF2L1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDF2L1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21

SDF2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDF2L1 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P021996: view genomic region (about GC identifiers)

Start:	21,996,542 bp from pter	End:	21,998,588 bp from pter
Size:	2,047 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SDF2L_HUMAN, Q9HCN8 (See protein sequence)

Recommended Name: Stromal cell-derived factor 2-like protein 1 precursor

Size: 221 amino acids; 23598 Da

Subcellular location: Endoplasmic reticulum lumen (Potential)

Secondary accessions: A2RUD3 Q9BRI5

Explore the universe of human proteins at neXtProt for SDF2L1: NX_Q9HCN8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HCN8

SDF2L1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_071327.2

ENSEMBL proteins:

ENSP00000248958

Human Recombinant Protein Products:

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	Uscn Proteins for SDF2L1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005788	endoplasmic reticulum lumen	IEA	--
GO:0016020	membrane	IEA	--

SDF2L1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SDF2L1 for domains About GeneDecksing

2 InterPro domains/families:

IPR027005 GlyclTrfase_39_like

IPR016093 MIR_motif

Graphical View of Domain Structure for InterPro Entry Q9HCN8

ProtoNet protein and cluster: Q9HCN8

1 Blocks protein family: IPB003608 MIR domain

UniProtKB/Swiss-Prot: SDF2L_HUMAN, Q9HCN8

Similarity: Contains 3 MIR domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for SDF2L1:

stromal cell-derived factor 2-like 1

miRNA Products:		OriGene 3'-UTR Clone: SDF2L1 Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SDF2L1

2 GenomeRNAi human phenotypes for SDF2L1:

Decreased TP53 protein express

Decreased homologous recombina

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SDF2L1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/11 Interacting proteins for SDF2L1 (Q9HCN8³ ENSP00000248958⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
UEVLD	Q8IX04³, ENSP00000379500⁴	I2D: score=1 STRING: ENSP00000379500
RRP1B	Q14684³, ENSP00000339145⁴	I2D: score=1 STRING: ENSP00000339145
TERF2	Q15554³, ENSP00000254942⁴	I2D: score=1 STRING: ENSP00000254942
ATG5	Q9H1Y0³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SDF2L1
Search CenterWatch for drugs/clinical trials and news about SDF2L1 / SDF2L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SDF2L1 gene:

NM_022044.2

Unigene Cluster for SDF2L1:

Stromal cell-derived factor 2-like 1

Hs.303116 [show with all ESTs]

Unigene Representative Sequence: BU588938

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000248958(uc002zvf.3) ENST00000466935

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate SDF2L1:
		hsa-miR-124 hsa-miR-1283 hsa-miR-186* hsa-miR-506 hsa-miR-543 hsa-miR-1224-5p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDF2L1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDF2L1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDF2L1
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDF2L1

Additional cDNA sequence:

AB043007.1 AF277316.1 AY359118.1 BC132849.1 BC132851.1 BC139837.1 CR456570.1

6 DOTS entries:

DT.210345 DT.97782604 DT.100782168 DT.120651058 DT.40115176 DT.95347577

24/144 AceView cDNA sequences (see all 144):

BE388276 BU538689 CD556819 AI468402 CA776971 BG774895 BI826165 CR456570

AI739099 BG913385 AA383935 BE796310 AF277316 BI792867 BU956380 BQ922787

BI793131 AI985119 BI858908 CR612706 CB144964 BM856497 CA777258 AI638546

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SDF2L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGGCATCT

About this image

SDF2L1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SDF2L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SDF2L1

SOURCE GeneReport for Unigene cluster: Hs.303116

UniProtKB/Swiss-Prot: SDF2L_HUMAN, Q9HCN8

Tissue specificity: Ubiquitously expressed with high expression in testis, moderate expression in the pancreas, spleen,

prostate, small intestine and colon. Very low expression is seen in brain and skeletal muscle

SABiosciences Custom PCR Arrays for SDF2L1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDF2L1

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SDF2L1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SDF2L1 gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SDF2L1¹	stromal cell-derived factor 2-like 1	69.05(n) 78.1(a)		416770 XM_001232857.2 XP_001232858.1
lizard (Anolis carolinensis)	Reptilia	SDF2L1⁶	--	73(a)	1 ↔ 1	GL343282.1(1175858-1180757)
African clawed frog (Xenopus laevis)	Amphibia	Xl.5458²	Xenopus laevis transcribed sequence with weak similarity more	72.22(n)		BJ042972.1
zebrafish (Danio rerio)	Actinopterygii	sdf2l1¹	stromal cell-derived factor 2-like 1	63.78(n) 69.23(a)		445275 NM_001003730.1 NP_001003730.1
fruit fly (Drosophila melanogaster)	Insecta	CG11999³	--	51(a)		82F10 --
worm (Caenorhabditis elegans)	Secernentea	R12E2.13³	--	50(a)		I(4177363-4178553) --
thale cress (Arabidopsis thaliana)	eudicotyledons	SDF2⁶	stromal cell-derived factor 2-like protein	35(a)	1 → many	2(10684135-10686085)
rice (Oryza sativa)	Liliopsida	-- --	stromal cell-derived factor 2-like protein precurs... stromal cell-derived factor 2-like protein precurs...	36(a) 35(a)	many ↔ many many ↔ many	8(21430885-21434022) 8(10809316-10812338)

ENSEMBL Gene Tree for SDF2L1 (if available)
TreeFam Gene Tree for SDF2L1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SDF2L1 gene

SDF2²

1 SIMAP similar gene for SDF2L1 using alignment to 1 protein entry: SDF2L_HUMAN:

SDF2

SDF2L1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181984435^1,2		--	21994663(+)	`GAGATC/TGTGCC`	1	--	us2k¹		0	--	--	--	--
rs201222131^1,2		--	21994694(+)	`ACAGA-/GTAAGA`	1	--	us2k¹		0	--	--	--	--
rs34113121^1,2	C	--	21994737(+)	`AAAAAA/GGACTT`	1	--	us2k¹		0	--	--	--	--
rs185923309^1,2		--	21994898(+)	`ACATGG/TTGAAA`	1	--	us2k¹		0	--	--	--	--
rs861849^1,2	C,A,	--	21995031(-)	`gatctC/Tggctc`	1	--	us2k¹		3		NA MN CSA	187
rs189070761^1,2		--	21995231(+)	`AGGGCA/GGAGAC`	1	--	us2k¹		0	--	--	--	--
rs138628218^1,2		--	21995314(+)	`CTCAGA/GTAGTA`	1	--	us2k¹		0	--	--	--	--
rs111560347^1,2	C,	--	21995531(+)	`TTCTGA/CACGCA`	1	--	us2k¹		2		CSA WA	120
rs149320285^1,2		--	21995633(+)	`ATTTGC/TTCTGT`	1	--	us2k¹		0	--	--	--	--
rs79812126^1,2		--	21995826(+)	`CCCTTG/TGTCTC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SDF2L1 (21996542 - 21998588 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SDF2L1
1 CNV: 50817

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDF2L1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SDF2L1 for disorders           About GeneDecksing

OMIM gene information: 607551    OMIM disorders: --

3 diseases for SDF2L1:    About MalaCards

metastasis efficiency malaria prostatitis

Export disorders for SDF2L1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SDF2L1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SDF2L1)

Utopia: connect your pdf to the dynamic
world of online information

Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family. (PubMed id 11162531)^{1, 2, 3, 9} Fukuda S.... Kamiya K. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 3} Dunham I....O'Brien K.P. (1999)
Global landscape of HIV-human protein complexes. (PubMed id 22190034)¹ Jager S....Krogan N.J. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)¹ Emanuele M.J....Elledge S.J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23753	HGNC: 10676	AceView: SDF2L1	Ensembl:ENSG00000128228	euGenes: HUgn23753
ECgene: SDF2L1	H-InvDB: SDF2L1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SDF2L1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SDF2L1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SDF2L1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SDF2L1 gene:
Search GeneIP for patents involving SDF2L1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SDF2L1
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SDF2L1 gene at Home site.

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SDF2L1 Gene

stromal cell-derived factor 2-like 1

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SDF2L1 Gene

stromal cell-derived factor 2-like 1

Aliasesfor SDF2L1 gene

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