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Aliases for SDF2L1 Gene

Aliases for SDF2L1 Gene

  • Stromal Cell Derived Factor 2 Like 1 2 3 5
  • PWP1-Interacting Protein 8 2 4
  • Stromal Cell-Derived Factor 2-Like 1 2
  • Dihydropyrimidinase-Like 2 2
  • SDF2-Like Protein 1 4

External Ids for SDF2L1 Gene

Previous GeneCards Identifiers for SDF2L1 Gene

  • GC22P018695
  • GC22P020320
  • GC22P020321
  • GC22P021996
  • GC22P004954
  • GC22P021741
  • GC22P021810
  • GC22P021827
  • GC22P021858
  • GC22P021874

Summaries for SDF2L1 Gene

GeneCards Summary for SDF2L1 Gene

SDF2L1 (Stromal Cell Derived Factor 2 Like 1) is a Protein Coding gene. GO annotations related to this gene include chaperone binding and misfolded protein binding. An important paralog of this gene is SDF2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDF2L1 Gene

Genomics for SDF2L1 Gene

Regulatory Elements for SDF2L1 Gene

Enhancers for SDF2L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G021582 1.1 dbSUPER 12.4 -58.9 -58918 1.4 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 ZBTB7B YY1 CCDC116 THAP7 IGLV5-52 THAP7-AS1 YDJC SDF2L1 ABHD17AP4 MIR301B PPIL2 ENSG00000234630
GH22G021606 1 dbSUPER 12.4 -34.6 -34612 2.2 PKNOX1 SIN3A YY1 ZNF121 FOS KLF13 CAVIN1 TAF15 JUNB KAT8 CCDC116 YDJC SDF2L1 PIR33609 ENSG00000275293
GH22G021579 0.9 dbSUPER 12.4 -62.2 -62161 0.7 HNRNPUL1 HDGF HDAC1 PTBP1 ARNT NFXL1 ZNF121 SMARCA5 CEBPB SREBF1 YDJC CCDC116 SDF2L1 ABHD17AP4 MIR301B PPIL2 ENSG00000275293 PIR33609
GH22G021615 0.7 dbSUPER 12.7 -26.4 -26401 0.4 CTCF L3MBTL2 TBL1XR1 ZNF740 ZBED1 BACH1 ZNF407 YBX1 RBBP5 ZNF354B SDF2L1 PIR33609 ENSG00000275293
GH22G021581 0.7 dbSUPER 12.4 -60.2 -60199 0.6 TSC22D4 CEBPG IRF9 POLR2A NCOR1 PRDM10 DNMT1 KLF13 ZNF362 ZBTB2 CCDC116 YDJC SDF2L1 ABHD17AP4 MIR301B PPIL2 ENSG00000275293 PIR33609
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SDF2L1 on UCSC Golden Path with GeneCards custom track

Promoters for SDF2L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000144038 147 1601 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS

Genomic Location for SDF2L1 Gene

Chromosome:
22
Start:
21,642,253 bp from pter
End:
21,644,299 bp from pter
Size:
2,047 bases
Orientation:
Plus strand

Genomic View for SDF2L1 Gene

Genes around SDF2L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDF2L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDF2L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDF2L1 Gene

Proteins for SDF2L1 Gene

  • Protein details for SDF2L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCN8-SDF2L_HUMAN
    Recommended name:
    Stromal cell-derived factor 2-like protein 1
    Protein Accession:
    Q9HCN8
    Secondary Accessions:
    • A2RUD3
    • Q9BRI5

    Protein attributes for SDF2L1 Gene

    Size:
    221 amino acids
    Molecular mass:
    23598 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SDF2L1 Gene

Post-translational modifications for SDF2L1 Gene

  • Glycosylation at isoforms=211
  • Modification sites at PhosphoSitePlus

Other Protein References for SDF2L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SDF2L1 Gene

Domains & Families for SDF2L1 Gene

Protein Domains for SDF2L1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SDF2L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SDF2L1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SDF2L1 Gene

Function for SDF2L1 Gene

Molecular function for SDF2L1 Gene

GENATLAS Biochemistry:
stromal cell-derived factor 2-like 1

Gene Ontology (GO) - Molecular Function for SDF2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity IBA --
GO:0051087 chaperone binding IEA --
GO:0051117 ATPase binding IEA --
GO:0051787 misfolded protein binding IEA --
genes like me logo Genes that share ontologies with SDF2L1: view
genes like me logo Genes that share phenotypes with SDF2L1: view

Animal Model Products

CRISPR Products

miRNA for SDF2L1 Gene

miRTarBase miRNAs that target SDF2L1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDF2L1 Gene

Localization for SDF2L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDF2L1 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDF2L1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3

Gene Ontology (GO) - Cellular Components for SDF2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016020 membrane IEA --
GO:0034663 endoplasmic reticulum chaperone complex IEA --
genes like me logo Genes that share ontologies with SDF2L1: view

Pathways & Interactions for SDF2L1 Gene

SuperPathways for SDF2L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDF2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress IEA --
GO:0035269 protein O-linked mannosylation IEA --
GO:0042981 regulation of apoptotic process IEA --
GO:0071218 cellular response to misfolded protein IEA --
GO:0071712 ER-associated misfolded protein catabolic process IEA,IBA --
genes like me logo Genes that share ontologies with SDF2L1: view

No data available for Pathways by source and SIGNOR curated interactions for SDF2L1 Gene

Drugs & Compounds for SDF2L1 Gene

No Compound Related Data Available

Transcripts for SDF2L1 Gene

mRNA/cDNA for SDF2L1 Gene

Unigene Clusters for SDF2L1 Gene

Stromal cell-derived factor 2-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDF2L1 Gene

No ASD Table

Relevant External Links for SDF2L1 Gene

GeneLoc Exon Structure for
SDF2L1
ECgene alternative splicing isoforms for
SDF2L1

Expression for SDF2L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDF2L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDF2L1 Gene

This gene is overexpressed in Liver (x5.5).

Protein differential expression in normal tissues from HIPED for SDF2L1 Gene

This gene is overexpressed in Lavage (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SDF2L1 Gene



Protein tissue co-expression partners for SDF2L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SDF2L1 Gene:

SDF2L1

SOURCE GeneReport for Unigene cluster for SDF2L1 Gene:

Hs.303116

mRNA Expression by UniProt/SwissProt for SDF2L1 Gene:

Q9HCN8-SDF2L_HUMAN
Tissue specificity: Ubiquitously expressed with high expression in testis, moderate expression in the pancreas, spleen, prostate, small intestine and colon. Very low expression is seen in brain and skeletal muscle.

Evidence on tissue expression from TISSUES for SDF2L1 Gene

  • Lung(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SDF2L1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SDF2L1 Gene

Orthologs for SDF2L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SDF2L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDF2L1 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia SDF2L1 34 35
  • 90.65 (n)
cow
(Bos Taurus)
Mammalia SDF2L1 34 35
  • 87.93 (n)
rat
(Rattus norvegicus)
Mammalia Sdf2l1 34
  • 86.77 (n)
mouse
(Mus musculus)
Mammalia Sdf2l1 34 16 35
  • 85.37 (n)
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-130b 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDF2L1 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDF2L1 34 35
  • 72.25 (n)
lizard
(Anolis carolinensis)
Reptilia SDF2L1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sdf2l1 34
  • 65.28 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5458 34
zebrafish
(Danio rerio)
Actinopterygii sdf2l1 34 35
  • 65.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11999 36 35
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea R12E2.13 36 35
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11079 35
  • 46 (a)
OneToMany
Species where no ortholog for SDF2L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDF2L1 Gene

ENSEMBL:
Gene Tree for SDF2L1 (if available)
TreeFam:
Gene Tree for SDF2L1 (if available)

Paralogs for SDF2L1 Gene

Paralogs for SDF2L1 Gene

(1) SIMAP similar genes for SDF2L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SDF2L1: view

Variants for SDF2L1 Gene

Sequence variations from dbSNP and Humsavar for SDF2L1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000056378 -- 21,640,882(+) CATCT(G/T)CAGAA upstream-variant-2KB
rs1001585621 -- 21,642,173(+) TCGCG(A/T)ACCGG upstream-variant-2KB
rs1001630409 -- 21,642,182(+) GGGGG(C/T)GGGCC upstream-variant-2KB
rs1001637826 -- 21,642,313(+) GCCCG(A/C)GGGGC utr-variant-5-prime
rs1001725339 -- 21,642,355(+) GCCGC(A/G)GCGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SDF2L1 Gene

Variant ID Type Subtype PubMed ID
nsv516806 CNV loss 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for SDF2L1 Gene

Gene Damage Index Score: 2.91; 48.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDF2L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDF2L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDF2L1 Gene

Disorders for SDF2L1 Gene

Relevant External Links for SDF2L1

Genetic Association Database (GAD)
SDF2L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDF2L1

No disorders were found for SDF2L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDF2L1 Gene

Publications for SDF2L1 Gene

  1. Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family. (PMID: 11162531) Fukuda S. … Kamiya K. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 22 64
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 64

Products for SDF2L1 Gene

Sources for SDF2L1 Gene

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