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Aliases for SDF2L1 Gene

Aliases for SDF2L1 Gene

  • Stromal Cell Derived Factor 2 Like 1 2 3
  • Stromal Cell-Derived Factor 2-Like 1 2 3 5
  • PWP1-Interacting Protein 8 2 3 4
  • Dihydropyrimidinase-Like 2 2 3
  • SDF2-Like Protein 1 3 4
  • OTTHUMT00000075032 3
  • SDF2-Like 1 3

External Ids for SDF2L1 Gene

Previous GeneCards Identifiers for SDF2L1 Gene

  • GC22P018695
  • GC22P020320
  • GC22P020321
  • GC22P021996
  • GC22P004954
  • GC22P021741
  • GC22P021810

Summaries for SDF2L1 Gene

GeneCards Summary for SDF2L1 Gene

SDF2L1 (Stromal Cell Derived Factor 2 Like 1) is a Protein Coding gene. GO annotations related to this gene include chaperone binding and misfolded protein binding. An important paralog of this gene is SDF2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDF2L1 Gene

Genomics for SDF2L1 Gene

Regulatory Elements for SDF2L1 Gene

Promoters for SDF2L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SDF2L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SDF2L1 Gene

Chromosome:
22
Start:
21,642,253 bp from pter
End:
21,644,299 bp from pter
Size:
2,047 bases
Orientation:
Plus strand

Genomic View for SDF2L1 Gene

Genes around SDF2L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDF2L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDF2L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDF2L1 Gene

Proteins for SDF2L1 Gene

  • Protein details for SDF2L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCN8-SDF2L_HUMAN
    Recommended name:
    Stromal cell-derived factor 2-like protein 1
    Protein Accession:
    Q9HCN8
    Secondary Accessions:
    • A2RUD3
    • Q9BRI5

    Protein attributes for SDF2L1 Gene

    Size:
    221 amino acids
    Molecular mass:
    23598 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SDF2L1 Gene

Proteomics data for SDF2L1 Gene at MOPED

Post-translational modifications for SDF2L1 Gene

  • Glycosylation at Ser 211
  • Modification sites at PhosphoSitePlus

Other Protein References for SDF2L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SDF2L1 Gene

Domains & Families for SDF2L1 Gene

Protein Domains for SDF2L1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SDF2L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCN8

UniProtKB/Swiss-Prot:

SDF2L_HUMAN :
  • Contains 3 MIR domains.
Domain:
  • Contains 3 MIR domains.
genes like me logo Genes that share domains with SDF2L1: view

No data available for Gene Families for SDF2L1 Gene

Function for SDF2L1 Gene

Molecular function for SDF2L1 Gene

GENATLAS Biochemistry:
stromal cell-derived factor 2-like 1
genes like me logo Genes that share phenotypes with SDF2L1: view

Animal Model Products

miRNA for SDF2L1 Gene

miRTarBase miRNAs that target SDF2L1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDF2L1 Gene

Localization for SDF2L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDF2L1 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDF2L1 Gene COMPARTMENTS Subcellular localization image for SDF2L1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3

Gene Ontology (GO) - Cellular Components for SDF2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034663 endoplasmic reticulum chaperone complex IEA --
genes like me logo Genes that share ontologies with SDF2L1: view

Pathways & Interactions for SDF2L1 Gene

SuperPathways for SDF2L1 Gene

No Data Available

Interacting Proteins for SDF2L1 Gene

Gene Ontology (GO) - Biological Process for SDF2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress IEA --
GO:0044845 chain elongation of O-linked mannose residue IBA --
GO:0071218 cellular response to misfolded protein IEA --
GO:1900101 regulation of endoplasmic reticulum unfolded protein response IBA --
genes like me logo Genes that share ontologies with SDF2L1: view

No data available for Pathways by source and SIGNOR curated interactions for SDF2L1 Gene

Drugs & Compounds for SDF2L1 Gene

No Compound Related Data Available

Transcripts for SDF2L1 Gene

mRNA/cDNA for SDF2L1 Gene

Unigene Clusters for SDF2L1 Gene

Stromal cell-derived factor 2-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SDF2L1 Gene

No ASD Table

Relevant External Links for SDF2L1 Gene

GeneLoc Exon Structure for
SDF2L1
ECgene alternative splicing isoforms for
SDF2L1

Expression for SDF2L1 Gene

mRNA expression in normal human tissues for SDF2L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDF2L1 Gene

This gene is overexpressed in Liver (x5.5).

Protein differential expression in normal tissues from HIPED for SDF2L1 Gene

This gene is overexpressed in Lavage (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SDF2L1 Gene



SOURCE GeneReport for Unigene cluster for SDF2L1 Gene Hs.303116

mRNA Expression by UniProt/SwissProt for SDF2L1 Gene

Q9HCN8-SDF2L_HUMAN
Tissue specificity: Ubiquitously expressed with high expression in testis, moderate expression in the pancreas, spleen, prostate, small intestine and colon. Very low expression is seen in brain and skeletal muscle.
genes like me logo Genes that share expression patterns with SDF2L1: view

Protein tissue co-expression partners for SDF2L1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SDF2L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SDF2L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SDF2L1 35
  • 87.93 (n)
  • 88.69 (a)
SDF2L1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SDF2L1 35
  • 90.65 (n)
  • 95.93 (a)
SDF2L1 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdf2l1 35
  • 85.37 (n)
  • 89.14 (a)
Sdf2l1 16
Sdf2l1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SDF2L1 35
  • 99.25 (n)
  • 99.1 (a)
SDF2L1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sdf2l1 35
  • 86.77 (n)
  • 93.81 (a)
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-130b 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDF2L1 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDF2L1 35
  • 72.25 (n)
  • 82.7 (a)
SDF2L1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SDF2L1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sdf2l1 35
  • 65.28 (n)
  • 73.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5458 35
zebrafish
(Danio rerio)
Actinopterygii sdf2l1 35
  • 65.28 (n)
  • 70.98 (a)
sdf2l1 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11999 37
  • 51 (a)
CG11999 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R12E2.13 37
  • 50 (a)
R12E2.13 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11079 36
  • 46 (a)
OneToMany
Species with no ortholog for SDF2L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDF2L1 Gene

ENSEMBL:
Gene Tree for SDF2L1 (if available)
TreeFam:
Gene Tree for SDF2L1 (if available)

Paralogs for SDF2L1 Gene

Paralogs for SDF2L1 Gene

(1) SIMAP similar genes for SDF2L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SDF2L1: view

Variants for SDF2L1 Gene

Sequence variations from dbSNP and Humsavar for SDF2L1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1947 -- 21,644,220(-) CCTGC(A/G)GACGC utr-variant-3-prime
rs440367 -- 21,642,619(+) GTCTG(A/G)AACCC intron-variant
rs450361 -- 21,642,622(+) TGAAA(C/G)CCGGG intron-variant
rs861848 -- 21,644,753(-) gcatg(A/G)tggct downstream-variant-500B
rs861849 -- 21,640,742(-) gatct(C/T)ggctc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SDF2L1 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv914458 CNV Loss 21882294
dgv4881n71 CNV Loss 21882294
nsv516806 CNV Loss 19592680
dgv4882n71 CNV Loss 21882294
nsv914469 CNV Loss 21882294

Variation tolerance for SDF2L1 Gene

Gene Damage Index Score: 2.91; 48.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDF2L1 Gene

HapMap Linkage Disequilibrium report
SDF2L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDF2L1 Gene

Disorders for SDF2L1 Gene

Relevant External Links for SDF2L1

Genetic Association Database (GAD)
SDF2L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDF2L1

No disorders were found for SDF2L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDF2L1 Gene

Publications for SDF2L1 Gene

  1. Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family. (PMID: 11162531) Fukuda S. … Kamiya K. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3

Products for SDF2L1 Gene

Sources for SDF2L1 Gene

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