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Aliases for SDF2 Gene

Aliases for SDF2 Gene

  • Stromal Cell-Derived Factor 2 2 3
  • SDF-2 3 4

External Ids for SDF2 Gene

Previous GeneCards Identifiers for SDF2 Gene

  • GC17M026820
  • GC17M028875
  • GC17M027121
  • GC17M023999
  • GC17M026975
  • GC17M023184

Summaries for SDF2 Gene

Entrez Gene Summary for SDF2 Gene

  • The protein encoded by this gene is believed to be a secretory protein. It has regions of similarity to hydrophilic segments of yeast mannosyltransferases. Its expression is ubiquitous and the gene appears to be relatively conserved among mammals. Alternate splicing results in both coding and non-coding variants. A pseudogene of this gene is located on chromosome 15. [provided by RefSeq, Dec 2011]

GeneCards Summary for SDF2 Gene

SDF2 (Stromal Cell-Derived Factor 2) is a Protein Coding gene. GO annotations related to this gene include dolichyl-phosphate-mannose-protein mannosyltransferase activity. An important paralog of this gene is SDF2L1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDF2 Gene

Genomics for SDF2 Gene

Regulatory Elements for SDF2 Gene

Genomic Location for SDF2 Gene

Start:
28,648,356 bp from pter
End:
28,662,189 bp from pter
Size:
13,834 bases
Orientation:
Minus strand

Genomic View for SDF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SDF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDF2 Gene

Proteins for SDF2 Gene

  • Protein details for SDF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99470-SDF2_HUMAN
    Recommended name:
    Stromal cell-derived factor 2
    Protein Accession:
    Q99470
    Secondary Accessions:
    • Q9BQ79

    Protein attributes for SDF2 Gene

    Size:
    211 amino acids
    Molecular mass:
    23026 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SDF2 Gene

Proteomics data for SDF2 Gene at MOPED

Post-translational modifications for SDF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SDF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SDF2 Gene

Domains for SDF2 Gene

Protein Domains for SDF2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SDF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q99470

UniProtKB/Swiss-Prot:

SDF2_HUMAN :
  • Q99470
Domain:
  • Contains 3 MIR domains.
genes like me logo Genes that share domains with SDF2: view

No data available for Gene Families for SDF2 Gene

Function for SDF2 Gene

Molecular function for SDF2 Gene

GENATLAS Biochemistry: stromal cell-derived factor 2

Gene Ontology (GO) - Molecular Function for SDF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity TAS 8918255
genes like me logo Genes that share ontologies with SDF2: view

Phenotypes for SDF2 Gene

GenomeRNAi human phenotypes for SDF2:
genes like me logo Genes that share phenotypes with SDF2: view

miRNA for SDF2 Gene

miRTarBase miRNAs that target SDF2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SDF2 Gene

Localization for SDF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDF2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDF2 Gene COMPARTMENTS Subcellular localization image for SDF2 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 3
lysosome 1

Gene Ontology (GO) - Cellular Components for SDF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 8918255
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SDF2: view

Pathways for SDF2 Gene

SuperPathways for SDF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation TAS 8918255
GO:0035269 protein O-linked mannosylation TAS 8918255
genes like me logo Genes that share ontologies with SDF2: view

No data available for Pathways by source for SDF2 Gene

Compounds for SDF2 Gene

(1) Drugbank Compounds for SDF2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Malonate Ion
141-82-2 target
genes like me logo Genes that share compounds with SDF2: view

Transcripts for SDF2 Gene

Unigene Clusters for SDF2 Gene

Stromal cell-derived factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SDF2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - -
SP2: - -
SP3: -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - -
SP7:

Relevant External Links for SDF2 Gene

GeneLoc Exon Structure for
SDF2
ECgene alternative splicing isoforms for
SDF2

Expression for SDF2 Gene

mRNA expression in normal human tissues for SDF2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDF2 Gene

SOURCE GeneReport for Unigene cluster for SDF2 Gene Hs.514036

genes like me logo Genes that share expressions with SDF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SDF2 Gene

Orthologs for SDF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SDF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDF2 35
  • 99.05 (n)
  • 99.53 (a)
SDF2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SDF2 35
  • 93.05 (n)
  • 95.73 (a)
SDF2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SDF2 35
  • 93.21 (n)
  • 97.16 (a)
SDF2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdf2 35
  • 91.31 (n)
  • 95.26 (a)
Sdf2 16
Sdf2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SDF2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDF2 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sdf2 35
  • 90.52 (n)
  • 94.79 (a)
chicken
(Gallus gallus)
Aves SDF2 35
  • 72.67 (n)
  • 79.65 (a)
SDF2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SDF2 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15478 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sdf2 35
  • 71.82 (n)
  • 78.87 (a)
Str.11212 35
zebrafish
(Danio rerio)
Actinopterygii sdf2 35
  • 68.9 (n)
  • 71.65 (a)
sdf2 36
  • 64 (a)
OneToOne
wufk23f01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001749 35
  • 54.43 (n)
  • 54.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11999 35
  • 55.56 (n)
  • 53.65 (a)
CG11999 36
  • 48 (a)
OneToMany
CG11999 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea R12E2.13 35
  • 54.1 (n)
  • 54.29 (a)
R12E2.13 36
  • 47 (a)
OneToMany
R12E2.13 37
  • 54 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SDF2 35
  • 49.73 (n)
  • 43.85 (a)
rice
(Oryza sativa)
Liliopsida Os08g0440500 35
  • 50.48 (n)
  • 46.24 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4577 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11079 36
  • 54 (a)
OneToMany
Species with no ortholog for SDF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDF2 Gene

ENSEMBL:
Gene Tree for SDF2 (if available)
TreeFam:
Gene Tree for SDF2 (if available)

Paralogs for SDF2 Gene

Paralogs for SDF2 Gene

Selected SIMAP similar genes for SDF2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SDF2 Gene

genes like me logo Genes that share paralogs with SDF2: view

Variants for SDF2 Gene

Sequence variations from dbSNP and Humsavar for SDF2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs622463 -- 28,648,556(-) GCTAT(G/T)TCATT utr-variant-3-prime, nc-transcript-variant
rs642199 -- 28,654,389(-) AACCC(A/C)ATGTT intron-variant
rs1263223 -- 28,654,853(-) tcagc(C/T)gcccg intron-variant
rs1784564 -- 28,648,090(-) acccg(C/G)caaca downstream-variant-500B
rs2874237 -- 28,652,529(+) GGTCT(C/T)GAACT intron-variant

Relevant External Links for SDF2 Gene

HapMap Linkage Disequilibrium report
SDF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SDF2 Gene

Disorders for SDF2 Gene

Relevant External Links for SDF2

Genetic Association Database (GAD)
SDF2
Human Genome Epidemiology (HuGE) Navigator
SDF2
genes like me logo Genes that share disorders with SDF2: view

No data available for UniProtKB/Swiss-Prot for SDF2 Gene

Publications for SDF2 Gene

  1. Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method. (PMID: 8918255) Hamada T. … Honjo T. (Gene 1996) 2 3 4 23
  2. Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling. (PMID: 19479237) Song X.Y. … Chan J.C. (Diabetologia 2009) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. (PMID: 15576338) Rosas-Acosta G. … Wilson V.G. (Mol. Cell Proteomics 2005) 3
  5. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25

Products for SDF2 Gene

Sources for SDF2 Gene

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