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Aliases for SDE2 Gene

Aliases for SDE2 Gene

  • SDE2 Telomere Maintenance Homolog 2 3 5
  • C1orf55 3 4
  • SDE2 Telomere Maintenance Homolog (S. Pombe) 2
  • Chromosome 1 Open Reading Frame 55 2
  • UPF0667 Protein C1orf55 3
  • Protein SDE2 Homolog 3
  • DJ671D7.1 3

External Ids for SDE2 Gene

Previous HGNC Symbols for SDE2 Gene

  • C1orf55

Previous GeneCards Identifiers for SDE2 Gene

  • GC01M226171

Summaries for SDE2 Gene

GeneCards Summary for SDE2 Gene

SDE2 (SDE2 Telomere Maintenance Homolog) is a Protein Coding gene. An important paralog of this gene is SF3A3.

Additional gene information for SDE2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDE2 Gene

Genomics for SDE2 Gene

Regulatory Elements for SDE2 Gene

Enhancers for SDE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H225995 1.9 FANTOM5 ENCODE dbSUPER 21 -0.9 -933 8.8 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF548 SP3 NFYC ZC3H11A MEF2D ACBD3 ACBD3-AS1 H3F3A SDE2 RPL34P7 TMEM63A GC01M225948
GH01H226060 1.4 ENCODE dbSUPER 23.4 -63.9 -63937 5.6 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SDE2 ACBD3-AS1 H3F3A MIXL1 LOC105373110 ACBD3 LBR ENSG00000272562 GC01P226072
GH01H226033 1.4 FANTOM5 Ensembl ENCODE 22.5 -35.6 -35582 3.5 CTCF SAP130 TAL1 ZNF175 MAX ZNF384 YY1 TCF12 ZNF316 POLR2A H3F3A SDE2 GC01M225948
GH01H226937 1.7 FANTOM5 ENCODE dbSUPER 11.7 -940.7 -940657 4.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CDC42BPA PRSS38 ZNF678 LOC100126822 RPL34P7 ACBD3 SDE2 LINC01703 COQ8A LOC100418874
GH01H225874 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +120.2 120205 10.1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOS ZNF548 LEFTY2 ACBD3 PYCR2 TMEM63A LEFTY1 ENSG00000255835 ENSG00000248322 SDE2 H3F3A ENSG00000242861
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SDE2 on UCSC Golden Path with GeneCards custom track

Promoters for SDE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021056 165 2001 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF548 SP3 NFYC ZC3H11A MEF2D

Genomic Locations for SDE2 Gene

Genomic Locations for SDE2 Gene
16,664 bases
Minus strand

Genomic View for SDE2 Gene

Genes around SDE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDE2 Gene

Proteins for SDE2 Gene

  • Protein details for SDE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SDE2 homolog
    Protein Accession:
    Secondary Accessions:
    • A8K4P3
    • Q5TD36
    • Q6ZS26
    • Q8NAG7

    Protein attributes for SDE2 Gene

    451 amino acids
    Molecular mass:
    49742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SDE2 Gene


neXtProt entry for SDE2 Gene

Post-translational modifications for SDE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SDE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SDE2 Gene

Domains & Families for SDE2 Gene

Gene Families for SDE2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SDE2 Gene


Suggested Antigen Peptide Sequences for SDE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SDE2 family.
  • Belongs to the SDE2 family.
genes like me logo Genes that share domains with SDE2: view

Function for SDE2 Gene

Phenotypes From GWAS Catalog for SDE2 Gene

genes like me logo Genes that share phenotypes with SDE2: view

Animal Model Products

CRISPR Products

miRNA for SDE2 Gene

miRTarBase miRNAs that target SDE2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDE2 Gene

Localization for SDE2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDE2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
mitochondrion 2
golgi apparatus 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with SDE2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SDE2 Gene

Pathways & Interactions for SDE2 Gene

No Data Available

Interacting Proteins for SDE2 Gene

Gene Ontology (GO) - Biological Process for SDE2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SDE2 Gene

Drugs & Compounds for SDE2 Gene

No Compound Related Data Available

Transcripts for SDE2 Gene

mRNA/cDNA for SDE2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SDE2 Gene

SDE2 telomere maintenance homolog (S. pombe):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDE2 Gene

No ASD Table

Relevant External Links for SDE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SDE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDE2 Gene

Protein differential expression in normal tissues from HIPED for SDE2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.0), Lymph node (11.8), and Heart (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SDE2 Gene

Protein tissue co-expression partners for SDE2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SDE2 Gene:


SOURCE GeneReport for Unigene cluster for SDE2 Gene:


Evidence on tissue expression from TISSUES for SDE2 Gene

  • Liver(4.3)
  • Muscle(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SDE2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDE2 Gene

Orthologs for SDE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SDE2 33
  • 99.48 (n)
C1ORF55 34
  • 99 (a)
(Bos Taurus)
Mammalia SDE2 33 34
  • 84.63 (n)
(Canis familiaris)
Mammalia SDE2 33 34
  • 77.13 (n)
(Mus musculus)
Mammalia Sde2 33 16 34
  • 76.48 (n)
(Rattus norvegicus)
Mammalia Sde2 33
  • 74.49 (n)
(Monodelphis domestica)
Mammalia SDE2 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia SDE2 34
  • 56 (a)
(Gallus gallus)
Aves C3H1ORF55 33
  • 59.34 (n)
SDE2 34
  • 54 (a)
(Anolis carolinensis)
Reptilia SDE2 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sde2 33
  • 56.07 (n)
Str.6740 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6972 33
(Danio rerio)
Actinopterygii sde2 34
  • 41 (a)
wufi34c02 33
fruit fly
(Drosophila melanogaster)
Insecta CG5986 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea F53F4.14 34
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP9 34
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1605 34
  • 33 (a)
Species where no ortholog for SDE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDE2 Gene

Gene Tree for SDE2 (if available)
Gene Tree for SDE2 (if available)

Paralogs for SDE2 Gene

Paralogs for SDE2 Gene

genes like me logo Genes that share paralogs with SDE2: view

Variants for SDE2 Gene

Sequence variations from dbSNP and Humsavar for SDE2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000195235 -- 225,994,095(+) TTTTT(G/T)TGAGA intron-variant
rs1000204923 -- 225,993,788(+) GAGAT(A/G)GGGCC intron-variant
rs1000458350 -- 225,999,654(+) TGAGA(A/G)CCACC upstream-variant-2KB
rs1000514442 -- 225,988,983(+) CCTTC(A/G)ACGGT intron-variant
rs1000519694 -- 225,995,502(+) TAATA(G/T)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SDE2 Gene

Variant ID Type Subtype PubMed ID
esv2762223 CNV gain 21179565
esv3589004 CNV loss 21293372
nsv524126 CNV gain 19592680

Variation tolerance for SDE2 Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDE2 Gene

Disorders for SDE2 Gene

Relevant External Links for SDE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SDE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDE2 Gene

Publications for SDE2 Gene

  1. Sde2: a novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe. (PMID: 21333630) Sugioka-Sugiyama R … Sugiyama T (Biochemical and biophysical research communications 2011) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress. (PMID: 27906959) Jo U … Kim H (PLoS genetics 2016) 3 60
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for SDE2 Gene

Sources for SDE2 Gene

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