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Aliases for SDE2 Gene

Aliases for SDE2 Gene

  • SDE2 Telomere Maintenance Homolog (S. Pombe) 2 3
  • C1orf55 3 4
  • Chromosome 1 Open Reading Frame 55 2
  • UPF0667 Protein C1orf55 3
  • DJ671D7.1 3

External Ids for SDE2 Gene

Previous HGNC Symbols for SDE2 Gene

  • C1orf55

Previous GeneCards Identifiers for SDE2 Gene

  • GC01M226171

Summaries for SDE2 Gene

GeneCards Summary for SDE2 Gene

SDE2 (SDE2 Telomere Maintenance Homolog (S. Pombe)) is a Protein Coding gene. An important paralog of this gene is SF3A3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDE2 Gene

Genomics for SDE2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SDE2 Gene

225,982,702 bp from pter
225,999,365 bp from pter
16,664 bases
Minus strand

Genomic View for SDE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SDE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDE2 Gene

No data available for Regulatory Elements for SDE2 Gene

Proteins for SDE2 Gene

  • Protein details for SDE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SDE2 homolog
    Protein Accession:
    Secondary Accessions:
    • A8K4P3
    • Q5TD36
    • Q6ZS26
    • Q8NAG7

    Protein attributes for SDE2 Gene

    451 amino acids
    Molecular mass:
    49742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SDE2 Gene


neXtProt entry for SDE2 Gene

Proteomics data for SDE2 Gene at MOPED

Post-translational modifications for SDE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SDE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SDE2 Gene

Domains & Families for SDE2 Gene

Protein Domains for SDE2 Gene


Suggested Antigen Peptide Sequences for SDE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SDE2 family.
  • Belongs to the SDE2 family.
genes like me logo Genes that share domains with SDE2: view

No data available for Gene Families for SDE2 Gene

Function for SDE2 Gene

Phenotypes for SDE2 Gene

GenomeRNAi human phenotypes for SDE2:
genes like me logo Genes that share phenotypes with SDE2: view

Animal Model Products

miRNA for SDE2 Gene

miRTarBase miRNAs that target SDE2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDE2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SDE2 Gene

Localization for SDE2 Gene

Subcellular locations from

Jensen Localization Image for SDE2 Gene COMPARTMENTS Subcellular localization image for SDE2 gene
Compartment Confidence
cytosol 3
nucleus 3
golgi apparatus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with SDE2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SDE2 Gene

Pathways & Interactions for SDE2 Gene

SuperPathways for SDE2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDE2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SDE2 Gene

Drugs & Compounds for SDE2 Gene

No Compound Related Data Available

Transcripts for SDE2 Gene

mRNA/cDNA for SDE2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SDE2 Gene

SDE2 telomere maintenance homolog (S. pombe):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDE2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDE2 Gene

No ASD Table

Relevant External Links for SDE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SDE2 Gene

mRNA expression in normal human tissues for SDE2 Gene

Protein differential expression in normal tissues from HIPED for SDE2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.0), Lymph node (11.8), and Heart (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDE2 Gene

SOURCE GeneReport for Unigene cluster for SDE2 Gene Hs.520192

genes like me logo Genes that share expression patterns with SDE2: view

Protein tissue co-expression partners for SDE2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SDE2 Gene

Orthologs for SDE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SDE2 35
  • 84.63 (n)
  • 79.06 (a)
SDE2 36
  • 77 (a)
(Canis familiaris)
Mammalia SDE2 35
  • 77.13 (n)
  • 68.82 (a)
SDE2 36
  • 67 (a)
(Mus musculus)
Mammalia Sde2 35
  • 76.48 (n)
  • 69.41 (a)
Sde2 16
Sde2 36
  • 66 (a)
(Pan troglodytes)
Mammalia SDE2 35
  • 99.48 (n)
  • 99.33 (a)
C1ORF55 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sde2 35
  • 74.49 (n)
  • 67.2 (a)
(Monodelphis domestica)
Mammalia SDE2 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia SDE2 36
  • 56 (a)
(Gallus gallus)
Aves C3H1ORF55 35
  • 59.34 (n)
  • 56.81 (a)
SDE2 36
  • 54 (a)
(Anolis carolinensis)
Reptilia SDE2 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sde2 35
  • 56.07 (n)
  • 51.74 (a)
Str.6740 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6972 35
(Danio rerio)
Actinopterygii wufi34c02 35
sde2 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5986 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea F53F4.14 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP9 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1605 36
  • 33 (a)
Species with no ortholog for SDE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDE2 Gene

Gene Tree for SDE2 (if available)
Gene Tree for SDE2 (if available)

Paralogs for SDE2 Gene

Paralogs for SDE2 Gene

genes like me logo Genes that share paralogs with SDE2: view

Variants for SDE2 Gene

Sequence variations from dbSNP and Humsavar for SDE2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1885254 -- 225,992,208(+) GTTGT(A/G)TATGT intron-variant
rs1998272 -- 225,996,580(+) ATTGT(A/G)AAGTG intron-variant
rs1998273 -- 225,996,737(+) catta(C/T)aagat intron-variant
rs2067667 -- 225,991,549(-) AATCT(C/G)CTAGA intron-variant
rs2755090 -- 225,987,273(+) GTGTC(A/G)AGCTC intron-variant

Variation tolerance for SDE2 Gene

Residual Variation Intolerance Score: 44.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDE2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SDE2 Gene

Disorders for SDE2 Gene

Relevant External Links for SDE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SDE2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDE2 Gene

Publications for SDE2 Gene

  1. Sde2: a novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe. (PMID: 21333630) Sugioka-Sugiyama R. … Sugiyama T. (Biochem. Biophys. Res. Commun. 2011) 2 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 67
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67

Products for SDE2 Gene

Sources for SDE2 Gene

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