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Aliases for SDE2 Gene

Aliases for SDE2 Gene

  • SDE2 Telomere Maintenance Homolog 2 3
  • SDE2 Telomere Maintenance Homolog (S. Pombe) 2 5
  • C1orf55 3 4
  • Chromosome 1 Open Reading Frame 55 2
  • UPF0667 Protein C1orf55 3
  • DJ671D7.1 3

External Ids for SDE2 Gene

Previous HGNC Symbols for SDE2 Gene

  • C1orf55

Previous GeneCards Identifiers for SDE2 Gene

  • GC01M226171

Summaries for SDE2 Gene

GeneCards Summary for SDE2 Gene

SDE2 (SDE2 Telomere Maintenance Homolog) is a Protein Coding gene. An important paralog of this gene is SF3A3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDE2 Gene

Genomics for SDE2 Gene

Regulatory Elements for SDE2 Gene

Promoters for SDE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SDE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SDE2 Gene

Chromosome:
1
Start:
225,982,702 bp from pter
End:
225,999,365 bp from pter
Size:
16,664 bases
Orientation:
Minus strand

Genomic View for SDE2 Gene

Genes around SDE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDE2 Gene

Proteins for SDE2 Gene

  • Protein details for SDE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IQ49-SDE2_HUMAN
    Recommended name:
    Protein SDE2 homolog
    Protein Accession:
    Q6IQ49
    Secondary Accessions:
    • A8K4P3
    • Q5TD36
    • Q6ZS26
    • Q8NAG7

    Protein attributes for SDE2 Gene

    Size:
    451 amino acids
    Molecular mass:
    49742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SDE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDE2 Gene

Proteomics data for SDE2 Gene at MOPED

Post-translational modifications for SDE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SDE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SDE2 Gene

Domains & Families for SDE2 Gene

Protein Domains for SDE2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SDE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IQ49

UniProtKB/Swiss-Prot:

SDE2_HUMAN :
  • Belongs to the SDE2 family.
Family:
  • Belongs to the SDE2 family.
genes like me logo Genes that share domains with SDE2: view

No data available for Gene Families for SDE2 Gene

Function for SDE2 Gene

genes like me logo Genes that share phenotypes with SDE2: view

Animal Model Products

miRNA for SDE2 Gene

miRTarBase miRNAs that target SDE2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDE2 Gene

Localization for SDE2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDE2 Gene COMPARTMENTS Subcellular localization image for SDE2 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2
mitochondrion 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SDE2 Gene

Pathways & Interactions for SDE2 Gene

SuperPathways for SDE2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDE2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SDE2 Gene

Drugs & Compounds for SDE2 Gene

No Compound Related Data Available

Transcripts for SDE2 Gene

mRNA/cDNA for SDE2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SDE2 Gene

SDE2 telomere maintenance homolog (S. pombe):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SDE2 Gene

No ASD Table

Relevant External Links for SDE2 Gene

GeneLoc Exon Structure for
SDE2
ECgene alternative splicing isoforms for
SDE2

Expression for SDE2 Gene

mRNA expression in normal human tissues for SDE2 Gene

Protein differential expression in normal tissues from HIPED for SDE2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.0), Lymph node (11.8), and Heart (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDE2 Gene



SOURCE GeneReport for Unigene cluster for SDE2 Gene Hs.520192

genes like me logo Genes that share expression patterns with SDE2: view

Protein tissue co-expression partners for SDE2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SDE2 Gene

Orthologs for SDE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDE2 35
  • 99.48 (n)
  • 99.33 (a)
C1ORF55 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SDE2 36
  • 77 (a)
OneToOne
SDE2 35
  • 84.63 (n)
  • 79.06 (a)
dog
(Canis familiaris)
Mammalia SDE2 35
  • 77.13 (n)
  • 68.82 (a)
SDE2 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sde2 16
Sde2 35
  • 76.48 (n)
  • 69.41 (a)
Sde2 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SDE2 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDE2 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sde2 35
  • 74.49 (n)
  • 67.2 (a)
chicken
(Gallus gallus)
Aves SDE2 36
  • 54 (a)
OneToOne
C3H1ORF55 35
  • 59.34 (n)
  • 56.81 (a)
lizard
(Anolis carolinensis)
Reptilia SDE2 36
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6972 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sde2 35
  • 56.07 (n)
  • 51.74 (a)
Str.6740 35
zebrafish
(Danio rerio)
Actinopterygii sde2 36
  • 41 (a)
OneToOne
wufi34c02 35
fruit fly
(Drosophila melanogaster)
Insecta CG5986 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F53F4.14 36
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP9 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1605 36
  • 33 (a)
OneToOne
Species with no ortholog for SDE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDE2 Gene

ENSEMBL:
Gene Tree for SDE2 (if available)
TreeFam:
Gene Tree for SDE2 (if available)

Paralogs for SDE2 Gene

Paralogs for SDE2 Gene

genes like me logo Genes that share paralogs with SDE2: view

Variants for SDE2 Gene

Sequence variations from dbSNP and Humsavar for SDE2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34348128 - 225,988,094(+) GTAAC(A/C)ATCCT reference, missense
rs1885254 -- 225,992,208(+) GTTGT(A/G)TATGT intron-variant
rs2067667 -- 225,991,549(-) AATCT(C/G)CTAGA intron-variant
rs2755090 -- 225,987,273(+) GTGTC(A/G)AGCTC intron-variant
rs2755093 -- 226,000,198(+) TTTAA(C/T)AGAAT upstream-variant-2KB

Variation tolerance for SDE2 Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDE2 Gene

HapMap Linkage Disequilibrium report
SDE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SDE2 Gene

Disorders for SDE2 Gene

Relevant External Links for SDE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDE2

No disorders were found for SDE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDE2 Gene

Publications for SDE2 Gene

  1. Sde2: a novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe. (PMID: 21333630) Sugioka-Sugiyama R. … Sugiyama T. (Biochem. Biophys. Res. Commun. 2011) 2 3 67
  2. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 3
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3

Products for SDE2 Gene

Sources for SDE2 Gene

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