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Aliases for SDCCAG3 Gene

Aliases for SDCCAG3 Gene

  • Serologically Defined Colon Cancer Antigen 3 2 3 5
  • Antigen NY-CO-3 3 4
  • NY-CO-3 3

External Ids for SDCCAG3 Gene

Previous GeneCards Identifiers for SDCCAG3 Gene

  • GC09M130364
  • GC09M130985
  • GC09M132737
  • GC09M134653
  • GC09M136572
  • GC09M138417
  • GC09M139296
  • GC09M108755

Summaries for SDCCAG3 Gene

GeneCards Summary for SDCCAG3 Gene

SDCCAG3 (Serologically Defined Colon Cancer Antigen 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SDCCAG3 Gene

  • May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).

Additional gene information for SDCCAG3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDCCAG3 Gene

Genomics for SDCCAG3 Gene

Regulatory Elements for SDCCAG3 Gene

Enhancers for SDCCAG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H135967 1.3 Ensembl ENCODE 93.4 +443.0 442977 1 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B ZNF302 ZNF416 ZNF207 SDCCAG3 SNHG7 INPP5E SEC16A ENSG00000235572 OLFM1 LCN6 LCN10 ENSG00000238058 C9orf172
GH09H137233 1.8 FANTOM5 ENCODE dbSUPER 48.9 -827.7 -827697 9 MLX FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZC3H11A ZFP41 EHMT1 SDCCAG3 NDOR1 ANAPC2 LOC651337 INPP5E DPH7 MAN1B1 SEC16A IL9RP1
GH09H136942 1.4 ENCODE dbSUPER 41.1 -536.9 -536852 10 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B EHMT1 ANAPC2 SDCCAG3 DPH7 MAN1B1 SEC16A LCN12 LOC651337 NDOR1 SNHG7
GH09H135499 1.1 ENCODE 51.7 +909.5 909531 3 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF207 ZNF143 INPP5E SDCCAG3 SEC16A SNAPC4 OLFM1 COL5A1 QSOX2 COL5A1-AS1 C9orf116 MRPS2
GH09H137292 1.7 FANTOM5 ENCODE dbSUPER 30.2 -889.8 -889793 15 PKNOX1 FOXA2 ARNT ZFP64 SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 EHMT1 DPH7 INPP5E SDCCAG3 ANAPC2 EXD3 MAN1B1 NRARP NDOR1 SNAPC4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SDCCAG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SDCCAG3 Gene

Chromosome:
9
Start:
136,401,922 bp from pter
End:
136,410,609 bp from pter
Size:
8,688 bases
Orientation:
Minus strand

Genomic View for SDCCAG3 Gene

Genes around SDCCAG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDCCAG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDCCAG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDCCAG3 Gene

Proteins for SDCCAG3 Gene

  • Protein details for SDCCAG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C92-SDCG3_HUMAN
    Recommended name:
    Serologically defined colon cancer antigen 3
    Protein Accession:
    Q96C92
    Secondary Accessions:
    • A6NCP1
    • O60525
    • Q5SXN1
    • Q5SXN2
    • Q5SXN3
    • Q5SXN4
    • Q5SXN8
    • Q6V704
    • Q9NVY5

    Protein attributes for SDCCAG3 Gene

    Size:
    435 amino acids
    Molecular mass:
    47961 Da
    Quaternary structure:
    • Interacts with PTPN13, GIT1, VPS35 (PubMed:23108400, PubMed:25278552).
    SequenceCaution:
    • Sequence=BAA91607.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13936.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13942.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13943.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SDCCAG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDCCAG3 Gene

Post-translational modifications for SDCCAG3 Gene

  • Ubiquitination at isoforms=2, 3, 4349
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SDCCAG3 Gene

Domains & Families for SDCCAG3 Gene

Gene Families for SDCCAG3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SDCCAG3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SDCCAG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C92

UniProtKB/Swiss-Prot:

SDCG3_HUMAN :
  • Belongs to the SDCCAG3 family.
Family:
  • Belongs to the SDCCAG3 family.
genes like me logo Genes that share domains with SDCCAG3: view

Function for SDCCAG3 Gene

Molecular function for SDCCAG3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).

Phenotypes From GWAS Catalog for SDCCAG3 Gene

Gene Ontology (GO) - Molecular Function for SDCCAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23108400
genes like me logo Genes that share ontologies with SDCCAG3: view
genes like me logo Genes that share phenotypes with SDCCAG3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SDCCAG3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDCCAG3 Gene

Localization for SDCCAG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDCCAG3 Gene

Cytoplasm. Midbody. Early endosome. Recycling endosome. Note=During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400). Colocalizes in a WASHC2-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDCCAG3 gene
Compartment Confidence
endosome 5
mitochondrion 3
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SDCCAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IDA,IEA 25278552
GO:0005769 early endosome IEA,IDA 23108400
GO:0030496 midbody IEA,IDA 23108400
GO:0030904 colocalizes_with retromer complex IDA 25278552
genes like me logo Genes that share ontologies with SDCCAG3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SDCCAG3 Gene

Pathways & Interactions for SDCCAG3 Gene

SuperPathways for SDCCAG3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDCCAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007049 cell cycle IEA --
GO:0015031 protein transport IEA --
GO:0032465 regulation of cytokinesis IDA 23108400
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SDCCAG3: view

No data available for Pathways by source and SIGNOR curated interactions for SDCCAG3 Gene

Drugs & Compounds for SDCCAG3 Gene

No Compound Related Data Available

Transcripts for SDCCAG3 Gene

Unigene Clusters for SDCCAG3 Gene

Serologically defined colon cancer antigen 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SDCCAG3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SDCCAG3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8:
SP9: - - -
SP10: - -
SP11: -
SP12: - -
SP13: - - - - - -

Relevant External Links for SDCCAG3 Gene

GeneLoc Exon Structure for
SDCCAG3
ECgene alternative splicing isoforms for
SDCCAG3

Expression for SDCCAG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDCCAG3 Gene

Protein differential expression in normal tissues from HIPED for SDCCAG3 Gene

This gene is overexpressed in Bone (38.9), Pancreas (13.1), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SDCCAG3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SDCCAG3 Gene:

SDCCAG3

SOURCE GeneReport for Unigene cluster for SDCCAG3 Gene:

Hs.94300

Evidence on tissue expression from TISSUES for SDCCAG3 Gene

  • Skin(4.4)
  • Liver(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with SDCCAG3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDCCAG3 Gene

Orthologs for SDCCAG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SDCCAG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDCCAG3 33 34
  • 98.68 (n)
cow
(Bos Taurus)
Mammalia SDCCAG3 33 34
  • 85.42 (n)
dog
(Canis familiaris)
Mammalia SDCCAG3 33 34
  • 84.57 (n)
rat
(Rattus norvegicus)
Mammalia Sdccag3 33
  • 82.71 (n)
mouse
(Mus musculus)
Mammalia Sdccag3 33 16 34
  • 81.54 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SDCCAG3 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDCCAG3 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sdccag3 33
  • 54.73 (n)
Str.604 33
zebrafish
(Danio rerio)
Actinopterygii sdccag3 34
  • 32 (a)
OneToOne
Species where no ortholog for SDCCAG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SDCCAG3 Gene

ENSEMBL:
Gene Tree for SDCCAG3 (if available)
TreeFam:
Gene Tree for SDCCAG3 (if available)

Paralogs for SDCCAG3 Gene

Pseudogenes.org Pseudogenes for SDCCAG3 Gene

genes like me logo Genes that share paralogs with SDCCAG3: view

No data available for Paralogs for SDCCAG3 Gene

Variants for SDCCAG3 Gene

Sequence variations from dbSNP and Humsavar for SDCCAG3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1057519454 Pathogenic 136,410,732(+) GTTCG(C/T)GGCTG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs869025292 Pathogenic 136,412,502(+) CAATT(C/T)AGGAT upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000280431 -- 136,412,300(+) TGTAC(A/C)CTGAG intron-variant, upstream-variant-2KB
rs1000479449 -- 136,412,286(+) TGCCA(A/G)TTATG intron-variant, upstream-variant-2KB
rs1000840705 -- 136,408,835(+) ACCTC(A/G)CTGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SDCCAG3 Gene

Variant ID Type Subtype PubMed ID
esv2661983 CNV deletion 23128226
esv2739359 CNV deletion 23290073
esv2739360 CNV deletion 23290073
esv2759720 CNV loss 17122850
nsv1147587 CNV deletion 26484159
nsv469918 CNV loss 18288195
nsv509333 CNV insertion 20534489
nsv615963 CNV loss 21841781
nsv825173 CNV gain 20364138
nsv825174 CNV gain 20364138
nsv831760 CNV loss 17160897
nsv951202 CNV deletion 24416366

Variation tolerance for SDCCAG3 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.84; 83.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDCCAG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDCCAG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDCCAG3 Gene

Disorders for SDCCAG3 Gene

Relevant External Links for SDCCAG3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDCCAG3

No disorders were found for SDCCAG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDCCAG3 Gene

Publications for SDCCAG3 Gene

  1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan MJ … Old LJ (International journal of cancer 1998) 2 3 4 60
  2. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. (PMID: 25278552) McGough IJ … Cullen PJ (Journal of cell science 2014) 3 4 60
  3. The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. (PMID: 23108400) Hagemann N … Erdmann KS (Oncogene 2013) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SDCCAG3 Gene

Sources for SDCCAG3 Gene

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