SDCCAG3 Gene
protein-coding GIFtS: 45
GCID: GC09M139296
|
|
serologically defined colon cancer antigen 3
| |
Aliases
for SDCCAG3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serologically Defined Colon Cancer Antigen 31 2 | | NY-CO-31 2 | | Antigen NY-CO-32 3 |
Export aliases for SDCCAG3 gene to outside databasesPrevious GC identifers: GC09M130364 GC09M130985 GC09M132737 GC09M134653 GC09M136572 GC09M138417 GC09M108755 |
Summaries
for SDCCAG3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SDCG3_HUMAN, Q96C92Function: May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cellsurface (By similarity)
|
Genomic Views
for SDCCAG3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_024000.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SDCCAG3 gene promoter:
AML1a NRF-2 Pbx1a p53 MyoD Lmo2 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for SDCCAG3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDCCAG3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3SDCCAG3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M139296: view genomic region
(about GC identifiers)
Start:
|
139,296,374 bp from pter |
End:
|
139,305,061 bp from pter |
Size:
|
8,688 bases |
Orientation:
|
minus strand |
|
Proteins
for SDCCAG3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SDCG3_HUMAN, Q96C92 (See
protein sequence)Recommended Name: Serologically defined colon cancer antigen 3 Size: 435 amino acids; 47961 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAA91607.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAI13936.1; Type=Erroneous gene model prediction; Sequence=CAI13942.2; Type=Erroneous gene model prediction;Sequence=CAI13943.2; Type=Erroneous gene model prediction;
Secondary accessions: A6NCP1 O60525 Q5SXN1 Q5SXN2 Q5SXN3 Q5SXN4 Q5SXN8 Q6V704 Q9NVY5Alternative splicing: 4 isoforms: Q96C92-1 Q96C92-2 Q96C92-3 Q96C92-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SDCCAG3: NX_Q96C92
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96C92
SDCCAG3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001034796.1 NP_001034797.1 NP_006634.3
ENSEMBL proteins: ENSP00000349929 ENSP00000298537 ENSP00000360790 ENSP00000409255 ENSP00000360788 ENSP00000409357
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
SDCCAG3 for ontologies About GeneDecksing
SDCCAG3 Antibody Products:
Assay Products for SDCCAG3: |
Protein
Domains /
Families
for SDCCAG3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SDCCAG3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96C92ProtoNet protein and cluster: Q96C92 UniProtKB/Swiss-Prot: SDCG3_HUMAN, Q96C92Similarity: Belongs to the SDCCAG3 family |
Function
for SDCCAG3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SDCG3_HUMAN, Q96C92Function: May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cellsurface (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDCCAG3 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDCCAG3 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): SDCCAG3 (NM_006643) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SDCCAG3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDCCAG3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDCCAG3 |
|
Pathways & Interactions
for SDCCAG3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SDCCAG3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/10 Interacting proteins for SDCCAG3 (Q96C923 ENSP000003499294) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for SDCCAG3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SDCCAG3
Search CenterWatch for drugs/clinical trials and news about SDCCAG3 / SDCG3
|
Transcripts
for SDCCAG3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SDCCAG3 gene (3 alternative transcripts): NM_001039707.1 NM_001039708.1 NM_006643.3 Unigene Cluster for SDCCAG3: Serologically defined colon cancer antigen 3 Hs.94300 [show with all ESTs]Unigene Representative Sequence: NM_00103970711 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357365 ENST00000298537(uc004chi.3 uc004chj.3 uc004chk.3)
ENST00000371725 ENST00000461693 ENST00000481114 ENST00000417512 ENST00000466579
ENST00000486441 ENST00000468963 ENST00000371723 ENST00000446833
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDCCAG3 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDCCAG3 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SDCCAG3 (NM_006643) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SDCCAG3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDCCAG3 |
Additional cDNA sequence: AF039688.1 AK001296.1 AY129014.1 AY349357.1 BC014515.1 21 DOTS entries: DT.95283865 DT.101961706 DT.100648783 DT.97769569 DT.417733 DT.92432054 DT.417731 DT.121153888 DT.95283867 DT.97848004 DT.100794128 DT.100794126 DT.121153873 DT.92432056 DT.100794124 DT.121153865 DT.40118559 DT.92432053 DT.95284475 DT.100829219 DT.121153853 24/321 AceView cDNA sequences (see all 321): BX333885 CR610693 BM721727 BP429397 BQ058325 AA251287 BU624971 CF132712 AW272204 BU859343 CB054123 CR615820 BU845249 CB250699 BM504021 AI240557 BM475187 CN482783 AW083208 BE732164 AI474207 AL525186 CR597452 BM672708
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SDCCAG3 (see all 13) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SDCCAG3
|
Expression
for SDCCAG3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SDCCAG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTGAGTGC
About this image
See SDCCAG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SDCCAG3
SOURCE GeneReport for Unigene cluster: Hs.94300
SABiosciences Custom PCR Arrays for SDCCAG3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDCCAG3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SDCCAG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDCCAG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDCCAG3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDCCAG3 |
Orthologs
for SDCCAG3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SDCCAG3 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for SDCCAG3 (if available)
TreeFam Gene Tree for SDCCAG3 (if available) |
Paralogs
for SDCCAG3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SDCCAG3 gene
SDCCAG3 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SDCCAG3
PGOHUM00000234940 PGOHUM00000244346
|
Genomic Variants
for SDCCAG3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SDCCAG3 (139296374 - 139305061 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SDCCAG3
6 CNVs: 30353 3785 30350 30354 30355 0133 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDCCAG3 |
|
Disorders
/ Diseases
for SDCCAG3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SDCCAG3 for disorders About GeneDecksing
1  disease for SDCCAG3: About MalaCardscolon cancer
Export disorders for SDCCAG3 gene to outside databases
|
Publications
for SDCCAG3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SDCCAG3 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with SDCCAG3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of human colon cancer antigens recognized by autologous antibodies. (PubMed id 9610721)1, 2, 3 Scanlan M.J....Old L.J. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1 Anderson C.A....Rioux J.D. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for SDCCAG3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SDCCAG3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SDCCAG3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SDCCAG3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SDCCAG3 gene:
Search GeneIP for patents involving SDCCAG3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SDCCAG3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for SDCCAG3 | | OriGene Custom Protein Services for SDCCAG3 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SDCCAG3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDCCAG3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDCCAG3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDCCAG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDCCAG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDCCAG3 |
| |
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| |  |  |  |  | | | | |
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 | | | SDCCAG3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDCCAG3 |
|  |  |  | | | | ThermoFisher Antibodies for SDCCAG3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDCCAG3 |
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