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Aliases for SDCCAG3 Gene

Aliases for SDCCAG3 Gene

  • Serologically Defined Colon Cancer Antigen 3 2 3 5
  • Antigen NY-CO-3 3 4
  • NY-CO-3 3

External Ids for SDCCAG3 Gene

Previous GeneCards Identifiers for SDCCAG3 Gene

  • GC09M130364
  • GC09M130985
  • GC09M132737
  • GC09M134653
  • GC09M136572
  • GC09M138417
  • GC09M139296
  • GC09M108755

Summaries for SDCCAG3 Gene

GeneCards Summary for SDCCAG3 Gene

SDCCAG3 (Serologically Defined Colon Cancer Antigen 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SDCCAG3 Gene

  • May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDCCAG3 Gene

Genomics for SDCCAG3 Gene

Regulatory Elements for SDCCAG3 Gene

Enhancers for SDCCAG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G136224 1.4 Ensembl ENCODE dbSUPER 10 +184.9 184884 3.1 HDGF RB1 ZSCAN4 ARID4B SIN3A ZNF2 RAD21 HSF1 SCRT2 ZNF143 LHX3 NACC2 PMPCA SDCCAG3 QSOX2 OBP2A GC09M136222 PIR36610
GH09G136227 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10 +182.2 182235 1.2 L3MBTL2 BHLHE40 ATF2 FOSL1 JUND CREB1 FOS FOSL2 NFE2L2 QSOX2 PMPCA SDCCAG3 NOTCH1 PIR36610 GC09M136222
GH09G136437 0.9 ENCODE 12.3 -28.6 -28613 3.3 HDGF AGO1 SIN3A GLIS2 ZNF143 KLF7 DEK SP3 GLIS1 MXD3 SEC16A SNAPC4 PMPCA SDCCAG3 INPP5E GC09P136426
GH09G136365 0.7 ENCODE 11.2 +45.1 45067 1.3 NFIA NFIB REST RAD21 ZNF121 NFIC GLIS2 POLR2A SMARCA4 ZNF341 DNLZ INPP5E PMPCA SDCCAG3 GC09M136338
GH09G136441 0.6 ENCODE 12.2 -31.2 -31235 0.2 GATAD2A JUND POLR2A FOXA3 MAX HNF4A RAD21 GABPA YY1 FOXA1 SDCCAG3 PMPCA SEC16A GC09M136450 PIR54263 PIR43963 GC09M136482
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SDCCAG3 on UCSC Golden Path with GeneCards custom track

Promoters for SDCCAG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243015 -91 1801 HDGF MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for SDCCAG3 Gene

Chromosome:
9
Start:
136,401,922 bp from pter
End:
136,410,609 bp from pter
Size:
8,688 bases
Orientation:
Minus strand

Genomic View for SDCCAG3 Gene

Genes around SDCCAG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDCCAG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDCCAG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDCCAG3 Gene

Proteins for SDCCAG3 Gene

  • Protein details for SDCCAG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C92-SDCG3_HUMAN
    Recommended name:
    Serologically defined colon cancer antigen 3
    Protein Accession:
    Q96C92
    Secondary Accessions:
    • A6NCP1
    • O60525
    • Q5SXN1
    • Q5SXN2
    • Q5SXN3
    • Q5SXN4
    • Q5SXN8
    • Q6V704
    • Q9NVY5

    Protein attributes for SDCCAG3 Gene

    Size:
    435 amino acids
    Molecular mass:
    47961 Da
    Quaternary structure:
    • Interacts with PTPN13, GIT1, VPS35 (PubMed:23108400, PubMed:25278552).
    SequenceCaution:
    • Sequence=BAA91607.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13936.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13942.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13943.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SDCCAG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDCCAG3 Gene

Post-translational modifications for SDCCAG3 Gene

  • Ubiquitination at Lys349
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SDCCAG3 Gene

Domains & Families for SDCCAG3 Gene

Protein Domains for SDCCAG3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SDCCAG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C92

UniProtKB/Swiss-Prot:

SDCG3_HUMAN :
  • Belongs to the SDCCAG3 family.
Family:
  • Belongs to the SDCCAG3 family.
genes like me logo Genes that share domains with SDCCAG3: view

No data available for Gene Families for SDCCAG3 Gene

Function for SDCCAG3 Gene

Molecular function for SDCCAG3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).

Gene Ontology (GO) - Molecular Function for SDCCAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23108400
genes like me logo Genes that share ontologies with SDCCAG3: view
genes like me logo Genes that share phenotypes with SDCCAG3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDCCAG3 Gene

Localization for SDCCAG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDCCAG3 Gene

Cytoplasm. Midbody. Early endosome. Recycling endosome. Note=During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400). Colocalizes in a WASHC2-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDCCAG3 gene
Compartment Confidence
endosome 5
mitochondrion 3
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SDCCAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA,IDA 25278552
GO:0005769 early endosome IDA,IEA 23108400
GO:0030496 midbody IDA,IEA 23108400
GO:0030904 colocalizes_with retromer complex IDA 25278552
genes like me logo Genes that share ontologies with SDCCAG3: view

Pathways & Interactions for SDCCAG3 Gene

SuperPathways for SDCCAG3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDCCAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007049 cell cycle IEA --
GO:0015031 protein transport IEA --
GO:0032465 regulation of cytokinesis IDA 23108400
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SDCCAG3: view

No data available for Pathways by source and SIGNOR curated interactions for SDCCAG3 Gene

Transcripts for SDCCAG3 Gene

Unigene Clusters for SDCCAG3 Gene

Serologically defined colon cancer antigen 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDCCAG3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8:
SP9: - - -
SP10: - -
SP11: -
SP12: - -
SP13: - - - - - -

Relevant External Links for SDCCAG3 Gene

GeneLoc Exon Structure for
SDCCAG3
ECgene alternative splicing isoforms for
SDCCAG3

Expression for SDCCAG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDCCAG3 Gene

Protein differential expression in normal tissues from HIPED for SDCCAG3 Gene

This gene is overexpressed in Bone (38.9), Pancreas (13.1), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SDCCAG3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SDCCAG3 Gene:

SDCCAG3

SOURCE GeneReport for Unigene cluster for SDCCAG3 Gene:

Hs.94300

Evidence on tissue expression from TISSUES for SDCCAG3 Gene

  • Skin(4.4)
  • Liver(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with SDCCAG3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDCCAG3 Gene

Orthologs for SDCCAG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SDCCAG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDCCAG3 34 35
  • 98.68 (n)
cow
(Bos Taurus)
Mammalia SDCCAG3 34 35
  • 85.42 (n)
dog
(Canis familiaris)
Mammalia SDCCAG3 34 35
  • 84.57 (n)
rat
(Rattus norvegicus)
Mammalia Sdccag3 34
  • 82.71 (n)
mouse
(Mus musculus)
Mammalia Sdccag3 34 16 35
  • 81.54 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 67 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SDCCAG3 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDCCAG3 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sdccag3 34
  • 54.73 (n)
Str.604 34
zebrafish
(Danio rerio)
Actinopterygii sdccag3 35
  • 32 (a)
OneToOne
Species where no ortholog for SDCCAG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SDCCAG3 Gene

ENSEMBL:
Gene Tree for SDCCAG3 (if available)
TreeFam:
Gene Tree for SDCCAG3 (if available)

Paralogs for SDCCAG3 Gene

Pseudogenes.org Pseudogenes for SDCCAG3 Gene

genes like me logo Genes that share paralogs with SDCCAG3: view

No data available for Paralogs for SDCCAG3 Gene

Variants for SDCCAG3 Gene

Sequence variations from dbSNP and Humsavar for SDCCAG3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1057519454 Pathogenic 136,410,732(+) GTTCG(C/T)GGCTG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs869025292 Pathogenic 136,412,502(+) CAATT(C/T)AGGAT upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000280431 -- 136,412,300(+) TGTAC(A/C)CTGAG intron-variant, upstream-variant-2KB
rs1000479449 -- 136,412,286(+) TGCCA(A/G)TTATG intron-variant, upstream-variant-2KB
rs1000840705 -- 136,408,835(+) ACCTC(A/G)CTGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SDCCAG3 Gene

Variant ID Type Subtype PubMed ID
esv2661983 CNV deletion 23128226
esv2739359 CNV deletion 23290073
esv2739360 CNV deletion 23290073
esv2759720 CNV loss 17122850
nsv1147587 CNV deletion 26484159
nsv469918 CNV loss 18288195
nsv509333 CNV insertion 20534489
nsv615963 CNV loss 21841781
nsv825173 CNV gain 20364138
nsv825174 CNV gain 20364138
nsv831760 CNV loss 17160897
nsv951202 CNV deletion 24416366

Variation tolerance for SDCCAG3 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.84; 83.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDCCAG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDCCAG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDCCAG3 Gene

Disorders for SDCCAG3 Gene

Relevant External Links for SDCCAG3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDCCAG3

No disorders were found for SDCCAG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDCCAG3 Gene

Publications for SDCCAG3 Gene

  1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4 64
  2. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. (PMID: 25278552) McGough I.J. … Cullen P.J. (J. Cell Sci. 2014) 3 4 64
  3. The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. (PMID: 23108400) Hagemann N. … Erdmann K.S. (Oncogene 2013) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64

Products for SDCCAG3 Gene

Sources for SDCCAG3 Gene

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