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Aliases for SDCCAG3 Gene

Aliases for SDCCAG3 Gene

  • Serologically Defined Colon Cancer Antigen 3 2 3
  • Antigen NY-CO-3 3 4
  • NY-CO-3 3

External Ids for SDCCAG3 Gene

Previous GeneCards Identifiers for SDCCAG3 Gene

  • GC09M130364
  • GC09M130985
  • GC09M132737
  • GC09M134653
  • GC09M136572
  • GC09M138417
  • GC09M139296
  • GC09M108755

Summaries for SDCCAG3 Gene

GeneCards Summary for SDCCAG3 Gene

SDCCAG3 (Serologically Defined Colon Cancer Antigen 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SDCCAG3 Gene

  • May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDCCAG3 Gene

Genomics for SDCCAG3 Gene

Regulatory Elements for SDCCAG3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SDCCAG3 Gene

Start:
136,401,922 bp from pter
End:
136,410,609 bp from pter
Size:
8,688 bases
Orientation:
Minus strand

Genomic View for SDCCAG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SDCCAG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDCCAG3 Gene

Proteins for SDCCAG3 Gene

  • Protein details for SDCCAG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C92-SDCG3_HUMAN
    Recommended name:
    Serologically defined colon cancer antigen 3
    Protein Accession:
    Q96C92
    Secondary Accessions:
    • A6NCP1
    • O60525
    • Q5SXN1
    • Q5SXN2
    • Q5SXN3
    • Q5SXN4
    • Q5SXN8
    • Q6V704
    • Q9NVY5

    Protein attributes for SDCCAG3 Gene

    Size:
    435 amino acids
    Molecular mass:
    47961 Da
    Quaternary structure:
    • Interacts with PTPN13, GIT1, VPS35 (PubMed:23108400, PubMed:25278552).
    SequenceCaution:
    • Sequence=BAA91607.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13936.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13942.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13943.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SDCCAG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDCCAG3 Gene

Proteomics data for SDCCAG3 Gene at MOPED

Post-translational modifications for SDCCAG3 Gene

  • Ubiquitination at Lys349
  • Modification sites at PhosphoSitePlus

Other Protein References for SDCCAG3 Gene

No data available for DME Specific Peptides for SDCCAG3 Gene

Domains for SDCCAG3 Gene

Protein Domains for SDCCAG3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SDCCAG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C92

UniProtKB/Swiss-Prot:

SDCG3_HUMAN :
  • Q96C92
Family:
  • Belongs to the SDCCAG3 family.
genes like me logo Genes that share domains with SDCCAG3: view

No data available for Gene Families for SDCCAG3 Gene

Function for SDCCAG3 Gene

Molecular function for SDCCAG3 Gene

UniProtKB/Swiss-Prot Function: May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).

Gene Ontology (GO) - Molecular Function for SDCCAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23108400
genes like me logo Genes that share ontologies with SDCCAG3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SDCCAG3 Gene

Localization for SDCCAG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDCCAG3 Gene

Cytoplasm. Midbody. Early endosome. Recycling endosome. Note=During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400). Colocalizes in a FAM21-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDCCAG3 Gene COMPARTMENTS Subcellular localization image for SDCCAG3 gene
Compartment Confidence
mitochondrion 3
cytoskeleton 1
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SDCCAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005768 endosome IDA 25278552
GO:0005769 early endosome IDA 23108400
GO:0030496 midbody IDA 23108400
GO:0030904 colocalizes_with retromer complex IDA 25278552
genes like me logo Genes that share ontologies with SDCCAG3: view

Pathways for SDCCAG3 Gene

SuperPathways for SDCCAG3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDCCAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0015031 protein transport IEA --
GO:0032465 regulation of cytokinesis IDA 23108400
GO:0051301 cell division IEA --
GO:1990126 retrograde transport, endosome to plasma membrane IMP 25278552
genes like me logo Genes that share ontologies with SDCCAG3: view

No data available for Pathways by source for SDCCAG3 Gene

Transcripts for SDCCAG3 Gene

Unigene Clusters for SDCCAG3 Gene

Serologically defined colon cancer antigen 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDCCAG3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDCCAG3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8:
SP9: - - -
SP10: - -
SP11: -
SP12: - -
SP13: - - - - - -

Relevant External Links for SDCCAG3 Gene

GeneLoc Exon Structure for
SDCCAG3
ECgene alternative splicing isoforms for
SDCCAG3

Expression for SDCCAG3 Gene

mRNA expression in normal human tissues for SDCCAG3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDCCAG3 Gene

SOURCE GeneReport for Unigene cluster for SDCCAG3 Gene Hs.94300

genes like me logo Genes that share expressions with SDCCAG3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SDCCAG3 Gene

Orthologs for SDCCAG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SDCCAG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDCCAG3 35
  • 98.68 (n)
  • 99.75 (a)
SDCCAG3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SDCCAG3 35
  • 85.42 (n)
  • 84.4 (a)
SDCCAG3 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SDCCAG3 35
  • 84.57 (n)
  • 84.72 (a)
SDCCAG3 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdccag3 35
  • 81.54 (n)
  • 81.07 (a)
Sdccag3 16
Sdccag3 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SDCCAG3 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sdccag3 35
  • 82.71 (n)
  • 83.88 (a)
chicken
(Gallus gallus)
Aves SDCCAG3 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sdccag3 35
  • 54.73 (n)
  • 46.13 (a)
Str.604 35
zebrafish
(Danio rerio)
Actinopterygii sdccag3 36
  • 32 (a)
OneToOne
Species with no ortholog for SDCCAG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SDCCAG3 Gene

ENSEMBL:
Gene Tree for SDCCAG3 (if available)
TreeFam:
Gene Tree for SDCCAG3 (if available)

Paralogs for SDCCAG3 Gene

Pseudogenes.org Pseudogenes for SDCCAG3 Gene

genes like me logo Genes that share paralogs with SDCCAG3: view

No data available for Paralogs for SDCCAG3 Gene

Variants for SDCCAG3 Gene

Sequence variations from dbSNP and Humsavar for SDCCAG3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs10706 -- 136,406,962(+) AGCCG(C/G)TTCTA intron-variant
rs15095 -- 136,406,987(+) CAGAA(A/G)CAAAG intron-variant
rs1051957 -- 136,404,141(-) CAGGG(C/T)GCCAG synonymous-codon, reference
rs1131992 - 136,404,128(-) TGACC(A/G)TGGTG missense, reference
rs1132005 -- 136,402,475(-) AATCA(A/G)TGTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SDCCAG3 Gene

Variant ID Type Subtype PubMed ID
nsv825173 CNV Gain 20364138
nsv894294 CNV Loss 21882294
dgv8383n71 CNV Loss 21882294
dgv8384n71 CNV Loss 21882294
dgv8385n71 CNV Loss 21882294
dgv8386n71 CNV Loss 21882294
dgv8389n71 CNV Loss 21882294
dgv8390n71 CNV Loss 21882294
dgv8392n71 CNV Loss 21882294
nsv894357 CNV Loss 21882294
nsv509333 CNV Insertion 20534489
nsv482928 CNV Loss 15286789
dgv2426e1 CNV Complex 17122850
nsv469918 CNV Loss 18288195
dgv8394n71 CNV Loss 21882294
nsv831760 CNV Loss 17160897
nsv894364 CNV Loss 21882294
nsv894365 CNV Loss 21882294
nsv894366 CNV Loss 21882294
nsv894367 CNV Loss 21882294
nsv825174 CNV Gain 20364138
esv2739359 CNV Deletion 23290073
esv2739360 CNV Deletion 23290073
esv2661983 CNV Deletion 23128226

Relevant External Links for SDCCAG3 Gene

HapMap Linkage Disequilibrium report
SDCCAG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDCCAG3 Gene

Disorders for SDCCAG3 Gene

No disorders were found for SDCCAG3 Gene.

No data available for UniProtKB/Swiss-Prot for SDCCAG3 Gene

Publications for SDCCAG3 Gene

  1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4
  2. The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. (PMID: 23108400) Hagemann N. … Erdmann K.S. (Oncogene 2013) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. (PMID: 25278552) McGough I.J. … Cullen P.J. (J. Cell Sci. 2014) 3 4
  5. Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling. (PMID: 25391492) Lamoliatte F. … Thibault P. (Nat Commun 2014) 3

Products for SDCCAG3 Gene

Sources for SDCCAG3 Gene

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