V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

SDCCAG1 Gene

protein-coding   GIFtS: 54

GC14M049320
serologically defined colon cancer antigen 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
FLJ10051 1, 2
NY-CO-1 1, 2
Descriptions
Antigen NY-CO-1 3
serologically defined colon cancer antigen 1 2
External Ids
HGNC: 106631
Entrez Gene: 91472
UniProtKB: O605243
Ensembl: ENSG000001655257
Search outside databases for aliases for SDCCAG1 gene

Previous GC identifers: GC14M047572 GC14M044046 GC14M048240

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SDCCAG1 gene  

Entrez Gene cytogenetic band: 14q22   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q22

SDCCAG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M049320:     (about GC identifiers)

Start:
49,320,282 bp from pter
End:
49,389,289 bp from pter
Size:
69,008 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SDCG1_HUMAN, O60524 (See protein sequence)
Recommended Name: Serologically defined colon cancer antigen 1  
Size: 1076 amino acids; 122970 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAC18036.1; Type=Frameshift; Positions=1065; Sequence=AAH56687.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: Q8WW70 Q9NWG1
Alternative splicing: 2 isoforms:  O60524-1   O60524-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004704.2  

    ENSEMBL proteins: 
    ENSP00000371570 ENSP00000298310 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (SDCG1)
    Human Recombinant Proteins from Abnova (SDCCAG1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IDA18029348
    About this table

    Antibodies for SDCCAG1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SDCCAG1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (SDCG1), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for SDCCAG1

    Assays for SDCCAG1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR008616 Fibro_bd_N
     IPR008532 DUF814


       GeneDecks  SDCCAG1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O60524

    ProtoNet protein and cluster: O60524

    1 Blocks protein family: IPB008532 Protein of unknown function DUF814

    UniProtKB/Swiss-Prot: SDCG1_HUMAN, O60524
    Similarity: Belongs to the SDCCAG1 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SDCCAG1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004713

                  Applied Biosystems Silencer® siRNAs for SDCCAG1

                  Sigma-Aldrich siRNA for SDCCAG1  
                         Sigma-Aldrich shRNA for SDCCAG1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004713
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004713
                                     untagged cDNA clone in CMV expression vector: NM_004713 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004713

    Genatlas biochemistry entry for SDCCAG1:
    serologically defined colon cancer NY-CO-1
    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    3 Interacting proteins for SDCCAG1 (ENSP000002983103) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAGE1ENSP000003692503STRING (score=.898)
    CEP78ENSP000003657833STRING (score=.7)
    ZNF707ENSP000003514823STRING (score=.7)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for SDCCAG1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SDCCAG1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004713

                  Sigma-Aldrich siRNA for SDCCAG1  
                         Sigma-Aldrich shRNA for SDCCAG1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004713  

    REFSEQ mRNAs for SDCCAG1 gene: 

    NM_004713.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004713  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004713
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004713
                                     untagged cDNA clone in CMV expression vector: NM_004713 

    Additional cDNA sequence: 

    AF039687.1 AK000913.1 AK093783.1 AK293236.1 AK295010.1 AK304695.1 AK308537.1 AK314281.1 
    BC006001.1 BC020794.2 BC056687.1 BC064364.1 BC107764.1 BX640804.1 BX640807.1 BX648598.1 
    BX648753.1 

    24/27 DOTS entries (see all 27 ):

    DT.314388  DT.100679213  DT.207458  DT.97845610  DT.100737565  DT.101984317  DT.70103737  DT.95338023 
    DT.100737564  DT.95266837  DT.40130729  DT.86850342  DT.95257653  DT.95269900  DT.100754441  DT.120747983 
    DT.120748053  DT.120748055  DT.40113659  DT.40118666  DT.40228562  DT.100652426  DT.422407  DT.91817523 

    24/208 AceView cDNA sequences (see all 208 ):

    BC031007 F28854 AI147994 BE502352 BF984340 BM785476 BQ632296 BQ426116 
    BM455267 AW237403 AK000913 AW467242 BM477286 AJ457797 AA159181 BG287032 
    CR597660 AA669916 AA553574 AK093783 NM_004713 CA392683 AX748304 AA626602 

    highest scoring ESTs for SDCCAG1:

    AA159181 AL121422 BG942209 AA159259 AK000913 AU117386 BC006001 BC056687 BE255217 BF219060 

    Unigene Cluster for SDCCAG1:

    Serologically defined colon cancer antigen 1
    Hs.655964  [show with all ESTs]
    Unigene Representative Sequence: NM_004713


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SDCCAG1 (see all 9 )

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                                -                                                                                                                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:              -                                 

    About this scheme

    ECgene alternative splicing isoforms for SDCCAG1

    2 Ensembl transcripts including schematic representations:
    ENST00000382135  ENST00000298310  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SDCCAG1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SDCCAG1

    1 / 2 / 3

    7 probe-sets matching SDCCAG1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    43093_at2, 3 U95-B 1 1.00 1.00 0.99 1.06 AA159181 0.80 1.00 0.91 1

    39228_at2, 3 U95-A 1 0.69 1.00 0.88 0.96 T83979 0.40 1.00 0.76 1

    218649_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004713 0.60 1.00 0.82 1

    1557950_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    218649_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1569594_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1558675_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.655964

    Expression variation in blood from EXPOLDB for SDCCAG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for SDCCAG1 gene from 5/21 species (see all 21 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SDCCAG11   -- serologically defined colon cancer antigen 1 93.8(n)
    95.17(a)
    490678  XM_846136.1  XP_851229.1 
    chimpanzee
    (Pan troglodytes)
    SDCCAG11   -- serologically defined colon cancer antigen 1 99.54(n)
    99.72(a)
    452891  XM_509934.2  XP_509934.1 
    mouse
    (Mus musculus)
    Sdccag11, 5 125
    serologically defined colon cancer antigen 11, 5 88.44(n)1
    90.04(a)1
    662441  NM_025441.21  NP_079717.21 
     AK0052125  AK0166625  (see all 29)
    zebrafish
    (Danio rerio)
    Dr.103622   -- Transcribed sequence with moderate similarity to protein more 74.2(n)  57091435 
    fruit fly
    (Drosophila melanogaster)
    CG118471   -- CG11847 55.85(n)
    52.8(a)
    43018  NM_143084.1  NP_651341.1 
    About this table        Species with no ortholog for SDCCAG1

    ENSEMBL Gene Tree for SDCCAG1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/402 NCBI SNPs in SDCCAG1 are shown (see all 402 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 67)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs31261611,2
    A,C,F,H,O49390141(+) ggcgcG/Aatccc 1 -- ng314Minor allele frequency- A:0.06EU EA WA 418
    rs31008861,2
    A,C,F,H49389769(-) CCTTCG/CGAGAG 1 -- ng314Minor allele frequency- C:0.03EU EA WA 418
    rs18699741,2
    A,C,F,H49389676(-) GTTTCC/GTTACA 1 -- ng319Minor allele frequency- G:0.08NA EA MN EU WA 944
    rs31009061,2
    A,C,F,H49368712(-) AACCAT/AGCTTG 1 S/C mis111Minor allele frequency- A:0.07EU EA WA NA 980
    rs71429521,2
    C,F49389435(+) CGAATA/GAAGAT 1 -- ng311Minor allele frequency- G:0.07NA 90
    rs283660011,2
    F49389728(-) GAGAGT/CTCGCC 1 -- ng312Minor allele frequency- C:0.01MN EA 1252
    --
    rs31008871,2
    C49389249(-) AGGAAA/CTTGCG 1 -- ut510--------
    --
    rs31261621,2
    C49391161(+) AAGTTA/CTGGAG 1 -- ng310--------
    --
    rs145051,2
    C49320543(+) ACCTCT/CCAAAT 1 -- ut31 ese31Minor allele frequency- C:0.00MN 184
    rs21685381,2
    H49388101(-) TGAATC/GTGGCA 1 S/C mis1 ese34Minor allele frequency- G:0.00EU EA WA 366
    About this table

    HapMap Linkage Disequilibrium images for SDCCAG1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 608378

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10 PubMed articles for SDCCAG1 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9147 HGNC: 10663 AceView: SDCCAG1 Ensembl:ENSG00000165525 euGenes: HUgn9147
    ECgene: SDCCAG1 H-InvDB: SDCCAG1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for SDCCAG1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SDCCAG1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SDCCAG1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for SDCCAG1 Antibodies for SDCCAG1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for SDCCAG1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (SDCCAG1)
     Search for Antibodies
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (SDCG1)
     Antibodies (SDCG1)
     Search OriGene for SDCCAG1
     Search Tocris compounds for SDCCAG1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for SDCCAG1

    GeneCards Homepage    -    Last full update: 1 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    SDCCAG1 Gene at Home site.
    Version 2.41.1
    server4.xennexinc.com