Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SDCBP Gene

protein-coding   GIFtS: 63
GCID: GC08P059515

Syndecan Binding Protein (Syntenin)

  See SDCBP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Syndecan Binding Protein (Syntenin)1 2     SYCL2 3
Melanoma Differentiation-Associated Protein 92 3     TACIP182 3
Pro-TGF-Alpha Cytoplasmic Domain-Interacting Protein 182 3     ST12
Scaffold Protein Pbp12 3     Melanoma Differentiation Associated Protein-92
Syndecan-Binding Protein 12 3     syntenin-12
MDA-92 3     MDA93

External Ids:    HGNC: 106621   Entrez Gene: 63862   Ensembl: ENSG000001375757   OMIM: 6022175   UniProtKB: O005603   
ORGUL members:         

Export aliases for SDCBP gene to outside databases

Previous GC identifers: GC08P058539 GC08P059405 GC08P059188 GC08P059628 GC08P054952


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SDCBP Gene:
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the
cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal
domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization,
cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily
localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic
reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SDCBP Gene:
SDCBP (syndecan binding protein (syntenin)) is a protein-coding gene. Diseases associated with SDCBP include asthenopia, and melanoma. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is SDCBP2.

UniProtKB/Swiss-Prot: SDCB1_HUMAN, O00560
Function: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to
cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor
(IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the
cell surface in the early secretory pathway

Gene Wiki entry for SDCBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SDCBP gene promoter:
         MEF-2A   p53   MEF-2   Sox9   aMEF-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSDCBP promoter sequence
   Search Chromatin IP Primers for SDCBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SDCBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q12.1

SDCBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDCBP gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P059515:  view genomic region     (about GC identifiers)

Start:
59,465,483 bp from pter      End:
59,495,419 bp from pter
Size:
29,937 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SDCB1_HUMAN, O00560 (See protein sequence)
Recommended Name: Syntenin-1  
Size: 298 amino acids; 32444 Da
Subunit: Monomer and homodimer (By similarity). Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2
isoform 1, TGFA and IL5RA. Interacts with neurofascin, SDCBP2 and PTPRJ (By similarity)
Selected PDB 3D structures from and Proteopedia for SDCBP (see all 11):
1N99 (3D)        1NTE (3D)        1OBX (3D)        1OBY (3D)        1OBZ (3D)        1R6J (3D)    
Secondary accessions: B2R5Q7 B4DUH3 B7ZLN2 O00173 O43391 Q14CP2
Alternative splicing: 3 isoforms:  O00560-1   O00560-2   O00560-3   

Explore the universe of human proteins at neXtProt for SDCBP: NX_O00560

Explore proteomics data for SDCBP at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues1
  • Ubiquitination2 at Lys185
  • Modification sites at PhosphoSitePlus

  • See SDCBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001007068.1  NP_001007069.1  NP_001007070.1  NP_001007071.1  NP_005616.2  

    ENSEMBL proteins: 
     ENSP00000260130   ENSP00000409288   ENSP00000411771   ENSP00000395351   ENSP00000428184  
     ENSP00000430730   ENSP00000397820   ENSP00000391687  
    Reactome Protein details: O00560

    SDCBP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for SDCBP
    OriGene Protein Over-expression Lysate for SDCBP
    OriGene MassSpec for SDCBP
    OriGene Custom Protein Services for SDCBP
    GenScript Custom Purified and Recombinant Proteins Services for SDCBP
    Novus Biologicals SDCBP Proteins
    Novus Biologicals SDCBP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SDCBP
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SDCBP 

    SDCBP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SDCBP
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SDCBP
    OriGene Custom Antibody Services for SDCBP
    Novus Biologicals SDCBP Antibodies
    Abcam antibodies for SDCBP
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SDCBP
    LSBio Antibodies in human, mouse, rat for SDCBP

    SDCBP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SDCBP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SDCBP
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SDCBP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry O00560

    ProtoNet protein and cluster: O00560

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: SDCB1_HUMAN, O00560
    Similarity: Contains 2 PDZ (DHR) domains


    Find genes that share domains with SDCBP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SDCB1_HUMAN, O00560
    Function: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to
    cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor
    (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the
    cell surface in the early secretory pathway
    Induction: By IFNG/IFN-gamma in melanoma cells

         Gene Ontology (GO): Selected molecular function terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IEA--
    GO:0005109frizzled binding IPI18256285
    GO:0005137interleukin-5 receptor binding ISS11498591
    GO:0005515protein binding IPI18256285
    GO:0008022protein C-terminus binding IEA--
         
    Find genes that share ontologies with SDCBP           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SDCBP:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SDCBP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SDCBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SDCBP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SDCBP

    miRNA
    Products:
        
    miRTarBase miRNAs that target SDCBP:
    hsa-mir-26a-5p (MIRT050190), hsa-mir-30a-5p (MIRT028447), hsa-mir-155-5p (MIRT001503), hsa-mir-103a-3p (MIRT027019)

    Block miRNA regulation of human, mouse, rat SDCBP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SDCBP (see all 21):
    hsa-miR-1273 hsa-miR-3673 hsa-miR-3607-3p hsa-miR-103a hsa-miR-155 hsa-miR-3119 hsa-miR-23a hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidSDCBP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SDCBP
    Predesigned siRNA for gene silencing in human, mouse, rat SDCBP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SDCBP

    Clone
    Products:
         
    OriGene clones in human, mouse for SDCBP (see all 27)
    OriGene ORF clones in mouse, rat for SDCBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): SDCBP (NM_005625)
    Sino Biological Human cDNA Clone for SDCBP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDCBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDCBP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SDCBP
    Browse ESI BIO Cell Lines and PureStem Progenitors for SDCBP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDCBP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SDCB1_HUMAN, O00560: Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral
    membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm,
    cytosol. Cytoplasm, cytoskeleton. Note=Mainly membrane-associated. Localized to adherens junctions, focal
    adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified
    by mass spectrometry in melanosome fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    endoplasmic reticulum5
    extracellular5
    nucleus5
    plasma membrane5
    chloroplast1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11179419
    GO:0005737cytoplasm IDA18256285
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton NAS9391086

    Find genes that share ontologies with SDCBP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SDCBP About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    Neurofascin interactions0.00
    2Syndecan-4-mediated signaling events
    Syndecan-4-mediated signaling events
    3Syndecan-2-mediated signaling events
    Syndecan-2-mediated signaling events
    4Syndecan-1-mediated signaling events
    Syndecan-1-mediated signaling events
    5IL-5 Signaling Pathway
    IL-5 Signaling Pathway


    Find genes that share SuperPaths with SDCBP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for SDCBP
        IL-5 Signaling Pathway
    Syndecan-2-mediated signaling events
    Syndecan-1-mediated signaling events
    Syndecan-4-mediated signaling events


    1 Reactome Pathway for SDCBP
        Neurofascin interactions


        Pathway & Disease-focused RT2 Profiler PCR Array including SDCBP: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SDCBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SDCBP (O005601, 2, 3 ENSP000002601304) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SDCBPO005601, 2EBI-727004,EBI-727004 MINT-8368230 MINT-8368173 MINT-8368190 MINT-8368210
    CD6P302032, 3, ENSP000003232804MINT-62377 MINT-62376 I2D: score=3 STRING: ENSP00000323280
    EFNB1P981723, ENSP000002049614I2D: score=4 STRING: ENSP00000204961
    GRIA2P422623, ENSP000002644264I2D: score=4 STRING: ENSP00000264426
    GRIA3P422633, ENSP000003603024I2D: score=4 STRING: ENSP00000360302
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006612protein targeting to membrane NAS10230395
    GO:0006930substrate-dependent cell migration, cell extension NAS12037664
    GO:0007265Ras protein signal transduction IEA--
    GO:0007268synaptic transmission NAS9883737
    GO:0007411axon guidance TAS--

    Find genes that share ontologies with SDCBP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SDCBP (SDCB1)

    4 Novoseek inferred chemical compound relationships for SDCBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pip2 65.7 5 15961997 (2), 16884951 (1), 17214441 (1)
    heparan sulfate 28.4 4 15518882 (1)
    kainate 20.6 4 15797720 (3), 12597860 (1)
    glutamate 1.07 1 12570872 (1)



    Find genes that share compounds with SDCBP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SDCBP gene (5 alternative transcripts): 
    NM_001007067.1  NM_001007068.1  NM_001007069.1  NM_001007070.1  NM_005625.3  

    Unigene Cluster for SDCBP:

    Syndecan binding protein (syntenin)
    Hs.200804  [show with all ESTs]
    Unigene Representative Sequence: AK128645
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522243 ENST00000260130(uc003xto.3 uc003xtn.3 uc003xtr.3 uc003xtq.3 uc003xtp.3 uc011led.2)
    ENST00000447182 ENST00000413219 ENST00000424270 ENST00000523483(uc003xts.3)
    ENST00000520168 ENST00000519115 ENST00000522843 ENST00000447267 ENST00000520228
    ENST00000523441 ENST00000422546
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SDCBP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SDCBP (see all 21):
    hsa-miR-1273 hsa-miR-3673 hsa-miR-3607-3p hsa-miR-103a hsa-miR-155 hsa-miR-3119 hsa-miR-23a hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidSDCBP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SDCBP
    Predesigned siRNA for gene silencing in human, mouse, rat SDCBP
    Clone
    Products:
         
    OriGene clones in human, mouse for SDCBP (see all 27)
    OriGene ORF clones in mouse, rat for SDCBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): SDCBP (NM_005625)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDCBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDCBP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SDCBP
    OriGene qSTAR qPCR primer pairs in human, mouse for SDCBP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SDCBP
      QuantiTect SYBR Green Assays in human, mouse, rat SDCBP
      QuantiFast Probe-based Assays in human, mouse, rat SDCBP

    Additional mRNA sequence: 

    AF000652.1 AF006636.1 AK128645.1 AK295198.1 AK298697.1 AK300647.1 AK312274.1 BC013254.2 
    BC113674.1 BC113676.1 BC143915.1 BC143916.1 U83463.1 

    Selected DOTS entries (see all 27):

    DT.40133197  DT.95092477  DT.95092509  DT.100733012  DT.100638034  DT.100031330  DT.100687164  DT.121486814 
    DT.91657516  DT.100687158  DT.100687165  DT.121486907  DT.95092455  DT.100638293  DT.100645330  DT.100687160 
    DT.100687169  DT.101954178  DT.121486843  DT.121486845  DT.121486852  DT.92459999  DT.92460002  DT.95239205 

    Selected AceView cDNA sequences (see all 952):

    CB157943 AA418052 BM854357 AI337278 AW069559 CA394546 AI684136 CD517993 
    AA026201 BQ576010 CN483329 AI189192 AI093176 BF432595 AU102484 BM992628 
    BX415197 BQ683452 CB266964 CB120459 AW468214 BE620505 BP345098 BQ879521 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SDCBP (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c ^ 10 ^ 11a ·
    SP1:                                -     -                 -                             -     -                             -                 -               
    SP2:                                -     -                 -                             -     -                             -                 -               
    SP3:                                -     -                 -                             -     -                             -                 -               
    SP4:                                                        -                       -     -     -                             -                 -               
    SP5:                                                                                      -     -                             -                 -               

    ExUns: 11b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SDCBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SDCBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGCATTAA
    SDCBP Expression
    About this image


    SDCBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
    SDCBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SDCBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.200804

    UniProtKB/Swiss-Prot: SDCB1_HUMAN, O00560
    Tissue specificity: Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest
    expression in heart and placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including SDCBP: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SDCBP
    OriGene qSTAR qPCR primer pairs in human, mouse for SDCBP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SDCBP
    QuantiTect SYBR Green Assays in human, mouse, rat SDCBP
    QuantiFast Probe-based Assays in human, mouse, rat SDCBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDCBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SDCBP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sdcbp1 , 5 syndecan binding protein1, 5 87.25(n)1
    90.6(a)1
      4 (2.91 cM)5
    533781  NM_001098227.11  NP_001091697.11 
     63656505 
    chicken
    (Gallus gallus)
    Aves SDCBP1 syndecan binding protein (syntenin) 80.27(n)
    88.78(a)
      421136  NM_001031024.1  NP_001026195.1 
    lizard
    (Anolis carolinensis)
    Reptilia SDCBP6
    syndecan binding protein (syntenin)
    87(a)
    1 ↔ 1
    4(27646227-27663759)
    African clawed frog
    (Xenopus laevis)
    Amphibia sdcbp-prov2 syndecan binding protein (syntenin) 77.98(n)    BC043629.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.17782 Danio rerio mRNA similar to syndecan binding protein more 72.07(n)    BC044454.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0095691 AgaP_AGAP009569 53.27(n)
    51.01(a)
      1278930  XM_318581.4  XP_318581.1 


    ENSEMBL Gene Tree for SDCBP (if available)
    TreeFam Gene Tree for SDCBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SDCBP gene
    SDCBP22  
    1 SIMAP similar gene for SDCBP using alignment to 4 protein entries:     SDCB1_HUMAN (see all proteins):
    SDCBP2

    Find genes that share paralogs with SDCBP           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for SDCBP
    PGOHUM00000238342 PGOHUM00000257155 PGOHUM00000257211 PGOHUM00000257251


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SDCBP (see all 621)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864070501,2
    --59463754(+) GAGTTA/GAGCCC 5 -- us2k10--------
    rs1467572111,2
    --59463812(+) CTTTAA/TCTGTC 5 -- us2k10--------
    rs1488136031,2
    C--59463833(+) CCATGC/TGGGGA 5 -- us2k10--------
    rs1125572691,2
    C--59464062(+) CTTCTG/-GGTCT 5 -- us2k12Minor allele frequency- -:0.25CSA 4
    rs1425325701,2
    --59464232(+) TAAATC/TTATTT 5 -- us2k10--------
    rs1996014591,2
    --59464283(+) TTTTT-/TATTTAG 5 -- us2k10--------
    rs1442775581,2
    C--59464284(+) TTTTT-/ATTTAG 5 -- us2k10--------
    rs773335491,2
    F--59464402(+) CAAATA/GCCAAT 5 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1900820811,2
    --59464421(+) GATGGC/TATATA 5 -- us2k10--------
    rs1509515971,2
    C--59464531(+) GGACCA/GAGGGA 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for SDCBP (59465483 - 59495419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SDCBP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272044CNV Insertion20981092
    nsv397168CNV Loss16902084
    nsv831325CNV Gain17160897
    nsv890939CNV Gain21882294
    nsv890938CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SDCBP
    DNA2.0 Custom Variant and Variant Library Synthesis for SDCBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602217    OMIM disorders: --

    2 diseases for SDCBP:    
    About MalaCards
    asthenopia    melanoma

    1 disease from the University of Copenhagen DISEASES database for SDCBP:
    Asthenopia

    Find genes that share disorders with SDCBP           About GenesLikeMe

    5 Novoseek inferred disease relationships for SDCBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 2 58.3 1 12679023 (1)
    melanoma 40.4 49 17308124 (7), 16322237 (5), 18832467 (4), 17478924 (3) (see all 9)
    metastasis 28.9 21 18832467 (3), 16322237 (3), 17308124 (2), 17451681 (2) (see all 10)
    cancer 14.9 19 17451681 (2), 18451132 (2), 16322237 (2), 20228839 (2) (see all 9)
    tumors 6.64 16 18832467 (3), 16322237 (3), 17451681 (2), 17308124 (1) (see all 5)


    Export disorders for SDCBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SDCBP gene, integrated from 10 sources (see all 106):
    (articles sorted by number of sources associating them with SDCBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. (PubMed id 9391086)1, 2, 3 Grootjans J.J.... David G. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments. (PubMed id 11179419)1, 2, 9 Zimmermann P.... David G. (Mol. Biol. Cell 2001)
    3. Schwannomin isoform-1 interacts with syntenin via PDZ domains. (PubMed id 11432873)1, 2, 9 Jannatipour M.... Rouleau G.A. (J. Biol. Chem. 2001)
    4. PDZ tandem of human syntenin: crystal structure and functional properties. (PubMed id 12679023)1, 2, 9 Kang B.S.... Derewenda Z.S. (Structure 2003)
    5. Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. (PubMed id 11498591)1, 2, 9 Geijsen N.... Coffer P.J. (Science 2001)
    6. The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography. (PubMed id 15081807)1, 2, 9 Kang B.S.... Derewenda Z.S. (J. Mol. Biol. 2004)
    7. A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface. (PubMed id 10230395)1, 2, 9 Fernandez-Larrea J....Arribas J. (Mol. Cell 1999)
    8. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)1, 2 Basrur V.... Appella E. (J. Proteome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6386 HGNC: 10662 AceView: SDCBP Ensembl:ENSG00000137575 euGenes: HUgn6386
    ECgene: SDCBP H-InvDB: SDCBP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SDCBP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SDCBP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SDCBP gene:
    Search GeneIP for patents involving SDCBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SDCBP
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SDCBP   OriGene RNAi products in human, mouse, rat for SDCBP  
     OriGene qPCR primer pairs and template standards for SDCBP   OriGene Protein Over-expression Lysate for SDCBP  
     OriGene MassSpec something-or-other for SDCBP   OriGene clones in human, mouse for SDCBP  
     OriGene qSTAR qPCR primer pairs in human, mouse for SDCBP   OriGene Purified Protein for SDCBP  
     OriGene ORF clones in mouse, rat for SDCBP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SDCBP   OriGene Custom Protein Services for SDCBP  

     
     
     Block miRNA regulation of human, mouse, rat SDCBP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SDCBP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SDCBP Predesigned siRNA for gene silencing in human, mouse, rat SDCBP
     QuantiFast Probe-based Assays in human, mouse, rat SDCBP QuantiTect SYBR Green Assays in human, mouse, rat SDCBP
     PCR Arrays including human, mouse, rat SDCBP Search Chromatin IP Primers for SDCBP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SDCBP  GeneGlobe Interaction Network for SDCBP
     Regulatory tfbs in SDCBP promoter
     GenScript Custom Purified and Recombinant Proteins Services for SDCBP GenScript cDNA clones with any tag delivered in your preferred vector for SDCBP
     GenScript Custom Assay Services for SDCBP GenScript Custom overexpressing Cell Line Services for SDCBP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SDCBP (SDCB1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SDCBP
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SDCBP antibodies
     SDCBP proteins
     SDCBP lysates
     Antibodies for SDCBP
     See all of Abcam's Antibodies, Kits and Proteins for SDCBP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SDCBP
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SDCBP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDCBP
     SwitchGear 3'UTR luciferase reporter plasmids for SDCBP
     SwitchGear Promoter luciferase reporter plasmids for SDCBP
     ThermoFisher Antibodies for SDCBP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDCBP
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SDCBP
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SDCBP
     LSBio Antibodies in human, mouse, rat for SDCBP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SDCBP
      Search eBioscience for proteins for SDCBP
      Search eBioscience for elisas for SDCBP
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SDCBP gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4