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Aliases for SDCBP Gene

Aliases for SDCBP Gene

  • Syndecan Binding Protein 2 3 5
  • Pro-TGF-Alpha Cytoplasmic Domain-Interacting Protein 18 3 4
  • Melanoma Differentiation-Associated Protein 9 3 4
  • Syndecan-Binding Protein 1 3 4
  • Scaffold Protein Pbp1 3 4
  • TACIP18 3 4
  • MDA-9 3 4
  • MDA9 3 4
  • SYCL 3 4
  • Melanoma Differentiation Associated Protein-9 3
  • Syndecan Binding Protein (Syntenin) 3
  • Syntenin-1 2
  • Syntenin 2
  • ST1 3

External Ids for SDCBP Gene

Previous GeneCards Identifiers for SDCBP Gene

  • GC08P059405
  • GC08P059188
  • GC08P059515
  • GC08P059628
  • GC08P054952

Summaries for SDCBP Gene

Entrez Gene Summary for SDCBP Gene

  • The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for SDCBP Gene

SDCBP (Syndecan Binding Protein) is a Protein Coding gene. Diseases associated with SDCBP include pontiac fever and asthenopia. Among its related pathways are Developmental Biology and EPH-Ephrin signaling. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is SDCBP2.

UniProtKB/Swiss-Prot for SDCBP Gene

  • Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).

Gene Wiki entry for SDCBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDCBP Gene

Genomics for SDCBP Gene

Regulatory Elements for SDCBP Gene

Genomic Location for SDCBP Gene

Chromosome:
8
Start:
58,552,924 bp from pter
End:
58,582,860 bp from pter
Size:
29,937 bases
Orientation:
Plus strand

Genomic View for SDCBP Gene

Genes around SDCBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDCBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDCBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDCBP Gene

Proteins for SDCBP Gene

  • Protein details for SDCBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00560-SDCB1_HUMAN
    Recommended name:
    Syntenin-1
    Protein Accession:
    O00560
    Secondary Accessions:
    • B2R5Q7
    • B4DUH3
    • B7ZLN2
    • O00173
    • O43391
    • Q14CP2

    Protein attributes for SDCBP Gene

    Size:
    298 amino acids
    Molecular mass:
    32444 Da
    Quaternary structure:
    • Monomer and homodimer (By similarity). Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA and IL5RA. Interacts with neurofascin, SDCBP2 and PTPRJ (By similarity). Interacts with PDCD6IP (PubMed:22660413). Forms a complex with PDCD6IP and SDC2 (PubMed:22660413). Interacts (via C-terminus) with TGFBR1 (PubMed:25893292).

    Three dimensional structures from OCA and Proteopedia for SDCBP Gene

    Alternative splice isoforms for SDCBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDCBP Gene

Proteomics data for SDCBP Gene at MOPED

Post-translational modifications for SDCBP Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for SDCBP

No data available for DME Specific Peptides for SDCBP Gene

Domains & Families for SDCBP Gene

Gene Families for SDCBP Gene

Protein Domains for SDCBP Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O00560

UniProtKB/Swiss-Prot:

SDCB1_HUMAN :
  • Contains 2 PDZ (DHR) domains.
Domain:
  • Contains 2 PDZ (DHR) domains.
genes like me logo Genes that share domains with SDCBP: view

Function for SDCBP Gene

Molecular function for SDCBP Gene

UniProtKB/Swiss-Prot Function:
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma in melanoma cells.

Gene Ontology (GO) - Molecular Function for SDCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005137 interleukin-5 receptor binding ISS 11498591
GO:0008093 cytoskeletal adaptor activity NAS 9391086
GO:0019838 growth factor binding IEA --
GO:0042043 neurexin family protein binding IEA --
GO:0045545 syndecan binding NAS 9391086
genes like me logo Genes that share ontologies with SDCBP: view
genes like me logo Genes that share phenotypes with SDCBP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDCBP Gene

Localization for SDCBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDCBP Gene

Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Secreted, exosome. Membrane raft. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269 PubMed:11179419, ECO:0000269 PubMed:12643545, ECO:0000269 PubMed:17081065}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDCBP Gene COMPARTMENTS Subcellular localization image for SDCBP gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for SDCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18256285
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton NAS 9391086
GO:0005895 interleukin-5 receptor complex ISS 11498591
GO:0005925 focal adhesion IEA --
genes like me logo Genes that share ontologies with SDCBP: view

Pathways & Interactions for SDCBP Gene

genes like me logo Genes that share pathways with SDCBP: view

Gene Ontology (GO) - Biological Process for SDCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002091 negative regulation of receptor internalization IMP 25893292
GO:0006930 substrate-dependent cell migration, cell extension NAS 12037664
GO:0007268 synaptic transmission IEA,NAS 9883737
GO:0007411 axon guidance TAS --
GO:0008284 positive regulation of cell proliferation IMP 26539120
genes like me logo Genes that share ontologies with SDCBP: view

No data available for SIGNOR curated interactions for SDCBP Gene

Drugs & Compounds for SDCBP Gene

(1) Drugs for SDCBP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SDCBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SDCBP: view

Transcripts for SDCBP Gene

Unigene Clusters for SDCBP Gene

Syndecan binding protein (syntenin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SDCBP Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c ^ 10 ^ 11a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - -
SP11: - -
SP12:
SP13: -
SP14:

ExUns: 11b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SDCBP Gene

GeneLoc Exon Structure for
SDCBP
ECgene alternative splicing isoforms for
SDCBP

Expression for SDCBP Gene

mRNA expression in normal human tissues for SDCBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDCBP Gene

This gene is overexpressed in Whole Blood (x9.5).

Protein differential expression in normal tissues from HIPED for SDCBP Gene

This gene is overexpressed in Urine (13.7), Amniocyte (9.4), and Milk (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDCBP Gene



SOURCE GeneReport for Unigene cluster for SDCBP Gene Hs.200804

mRNA Expression by UniProt/SwissProt for SDCBP Gene

O00560-SDCB1_HUMAN
Tissue specificity: Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.
genes like me logo Genes that share expression patterns with SDCBP: view

Protein tissue co-expression partners for SDCBP Gene

Primer Products

In Situ Assay Products

Orthologs for SDCBP Gene

This gene was present in the common ancestor of animals.

Orthologs for SDCBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDCBP 36
  • 93 (a)
OneToOne
SDCBP 35
  • 99.89 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SDCBP 35
  • 86.24 (n)
  • 92.95 (a)
SDCBP 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
SDCBP 35
  • 93.06 (n)
  • 94.63 (a)
mouse
(Mus musculus)
Mammalia Sdcbp 36
  • 90 (a)
OneToOne
Sdcbp 16
Sdcbp 35
  • 87.25 (n)
  • 90.6 (a)
oppossum
(Monodelphis domestica)
Mammalia SDCBP 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDCBP 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sdcbp 35
  • 86.35 (n)
  • 89.93 (a)
chicken
(Gallus gallus)
Aves SDCBP 35
  • 80.27 (n)
  • 88.78 (a)
SDCBP 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SDCBP 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sdcbp-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sdcbp 35
  • 74.58 (n)
  • 78.98 (a)
Str.6014 35
zebrafish
(Danio rerio)
Actinopterygii Dr.1778 35
sdcbp 35
  • 64.05 (n)
  • 70.65 (a)
sdcbp 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009569 35
  • 53.27 (n)
  • 51.01 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5544 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6469 36
  • 56 (a)
OneToMany
Species with no ortholog for SDCBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SDCBP Gene

ENSEMBL:
Gene Tree for SDCBP (if available)
TreeFam:
Gene Tree for SDCBP (if available)

Paralogs for SDCBP Gene

Paralogs for SDCBP Gene

(1) SIMAP similar genes for SDCBP Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SDCBP Gene

genes like me logo Genes that share paralogs with SDCBP: view

Variants for SDCBP Gene

Sequence variations from dbSNP and Humsavar for SDCBP Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_013160 -
VAR_053699 -
rs3739325 -- 58,580,553(+) CTGGG(A/G)CTGTA reference, missense
rs4307329 -- 58,579,032(+) AATGT(A/G)ACTGC intron-variant
rs7005920 -- 58,557,953(+) CTCTT(A/T)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SDCBP Gene

Variant ID Type Subtype PubMed ID
nsv890938 CNV Gain 21882294
nsv890939 CNV Gain 21882294
esv272044 CNV Insertion 20981092
nsv397168 CNV Loss 16902084
nsv831325 CNV Gain 17160897

Variation tolerance for SDCBP Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDCBP Gene

HapMap Linkage Disequilibrium report
SDCBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDCBP Gene

Disorders for SDCBP Gene

MalaCards: The human disease database

(3) MalaCards diseases for SDCBP Gene - From: DISEASES

Disorder Aliases PubMed IDs
pontiac fever
asthenopia
  • accommodative strain
disuse amblyopia
  • deprivation amblyopia
- elite association - COSMIC cancer census association via MalaCards
Search SDCBP in MalaCards View complete list of genes associated with diseases

Relevant External Links for SDCBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDCBP
genes like me logo Genes that share disorders with SDCBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDCBP Gene

Publications for SDCBP Gene

  1. Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. (PMID: 9391086) Grootjans J.J. … David G. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 67
  2. Src kinase activation is mandatory for MDA-9/syntenin-mediated activation of nuclear factor-kappaB. (PMID: 20228839) Boukerche H. … Fisher P.B. (Oncogene 2010) 3 23
  3. Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin. (PMID: 20145126) Hwangbo C. … Lee J.H. (Cancer Res. 2010) 3 23
  4. Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitment. (PMID: 19228696) Sulka B. … Rousselle P. (J. Biol. Chem. 2009) 3 23
  5. A novel immunoregulatory protein in human colostrum, syntenin-1, for promoting the development of IgA-producing cells from cord blood B cells. (PMID: 19592421) Sira M.M. … Miyawaki T. (Int. Immunol. 2009) 3 23

Products for SDCBP Gene

Sources for SDCBP Gene

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