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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SDC4 Gene

protein-coding GIFtS: 67
GCID: GC20M043953

syndecan 4

(Previous names: syndecan 4 (amphiglycan, ryudocan) )

Explore 12 diseases affiliated with
SDC4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Syndecan 4¹ ²		Ryudocan¹
SYND4¹ ² ³		Ryudocan Amphiglycan²
Amphiglycan³		Syndecan Proteoglycan 4²
Syndecan 4 (Amphiglycan, Ryudocan)¹ ²		Syndecan-4¹
Ryudocan Core Protein² ³		Amphiglycan³

External Ids:	HGNC: 10661¹	Entrez Gene: 6385²	Ensembl: ENSG00000124145⁷	OMIM: 600017⁵	UniProtKB: P31431³

Export aliases for SDC4 gene to outside databases

Previous GC identifers: GC20M043682 GC20M044592 GC20M044639 GC20M043387 GC20M040695

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SDC4:

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor

in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan

family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: SDC4_HUMAN, P31431

Function: Cell surface proteoglycan that bears heparan sulfate

Gene Wiki entry for SDC4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SDC4 gene promoter:
AP-1 ATF-2 MyoD c-Jun NF-kappaB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SDC4 promoter sequence

Search SABiosciences Chromatin IP Primers for SDC4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDC4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q12

SDC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDC4 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M043953: view genomic region (about GC identifiers)

Start:	43,953,928 bp from pter	End:	43,977,064 bp from pter
Size:	23,137 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SDC4_HUMAN, P31431 (See protein sequence)

Recommended Name: Syndecan-4 precursor

Size: 198 amino acids; 21642 Da

Subunit: Homodimer. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its

cytoplasmic domain) with NUDT16L1 (By similarity). Interacts with CDCP1 and SDCBP

Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the

ectodomain produces a soluble form (By similarity)

Subcellular location: Isoform 2: Secreted

4 PDB 3D structures from and Proteopedia for SDC4:

1EJP (3D)

1EJQ (3D)

1OBY (3D)

1YBO (3D)

Secondary accessions: O00773 Q16833 Q53FN9 Q6FGN3

Alternative splicing: 2 isoforms: P31431-1 P31431-2 (Soluble form, lacks the transmembrane domain)

Explore the universe of human proteins at neXtProt for SDC4: NX_P31431

Post-translational modifications:

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing.

PMA-mediated shedding is inhibited by TIMP3¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P31431

SDC4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002990.2

ENSEMBL proteins:

ENSP00000361818 ENSP00000445353

Reactome Protein details: P31431
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for SDC4 (Syndecan-4)
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SDC4 OriGene Custom Protein Services for SDC4
	GenScript Custom Purified and Recombinant Proteins Services for SDC4
	Novus Biologicals SDC4 Proteins Novus Biologicals SDC4 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SDC4
	Uscn Proteins for SDC4

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005796	Golgi lumen	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	1500433
GO:0005925	focal adhesion	IEA	--

SDC4 for ontologies About GeneDecksing

SDC4 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SDC4
	R&D Systems Antibodies for SDC4 (Syndecan-4)
	Cell Signaling Technology (CST) Antibodies for SDC4 (syndecan-4)
	Browse OriGene Antibodies OriGene Custom Antibody Services for SDC4
	GenScript Custom Superior Antibodies Services for SDC4
	Novus Biologicals SDC4 Antibodies
	Search for Antibodies for SDC4 at Abcam
	Uscn Antibodies for SDC4
	ThermoFisher Antibodies for SDC4

Assay Products for SDC4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for SDC4 (Syndecan-4) (see all)
	GenScript Custom Assay Services for SDC4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SDC4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SDC4 for domains About GeneDecksing

2 InterPro domains/families:

IPR003585 Neurexin-like

IPR001050 Syndecan

Graphical View of Domain Structure for InterPro Entry P31431

ProtoNet protein and cluster: P31431

2 Blocks protein families:

IPB001050 Syndecan

IPB003585 Neurexin/syndecan/glycophorin C

UniProtKB/Swiss-Prot: SDC4_HUMAN, P31431

Similarity: Belongs to the syndecan proteoglycan family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SDC4_HUMAN, P31431

Function: Cell surface proteoglycan that bears heparan sulfate

Genatlas biochemistry entry for SDC4:

syndecan 4,heparan sulfate proteoglycan 3 (22kDa),endothelial cell surface associated,cooperating with integrins in a

Rho dependent manner in the assembly of focal adhesion and actin stress fibers

miRNA Products:		miRTarBase miRNAs that target SDC4: hsa-mir-1 (MIRT002795)

		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDC4
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate SDC4 (see all 22):
		hsa-miR-142-3p hsa-miR-548k hsa-miR-16-1* hsa-miR-450b-3p hsa-miR-138-2* hsa-miR-764 hsa-miR-766 hsa-miR-3680

		SwitchGear 3'UTR luciferase reporter plasmid: SDC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDC4 (see all 7) OriGene shRNA RFP: SDC4 OriGene siRNA: SDC4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDC4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SDC4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDC4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDC4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SDC4 (NM_002999)
		Sino Biological Human cDNA Clone for SDC4
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDC4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SDC4
		Search LifeMap BioReagents cell lines for SDC4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDC4

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001968	fibronectin binding	IEA	--
GO:0005080	protein kinase C binding	IEA	--
GO:0005515	protein binding	IPI	12571249
GO:0008092	cytoskeletal protein binding	IEA	--
GO:0070053	thrombospondin receptor activity	IMP	17879962

SDC4 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for SDC4: Sdc4^tm1Goe Sdc4^tm1Tmu
     7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sdc4):

cardiovascular system	cellular	embryogenesis	homeostasis/metabolism	mortality/aging
muscle	renal/urinary system

SDC4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/16 pathways (see all 16)
MPS VI - Maroteaux-Lamy syndrome	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIID - Sanfilippo syndrome D	1.00
MPS I - Hurler syndrome	1.00	MPS IX - Natowicz syndrome	1.00
Mucopolysaccharidoses	1.00	MPS II - Hunter syndrome	1.00

HS-GAGs translocate to the lysosome for degradation

	HS-GAGs translocate to the lysosome for degradation	1.00			HS-GAG degradation	0.57
	Some HSPGs are secreted to the plasma membrane	1.00			Proteogylcan syndecan-mediated signaling events	0.33

Retinoid metabolism and transport

	Retinoid metabolism and transport	1.00			Diseases associated with visual transduction	0.73
	Visual phototransduction	0.74

Development FGFR signaling pathway

Development FGFR signaling pathway

1.00

Development_FGFR signaling pathway

0.98

A tetrasaccharide linker sequence is required for GAG synthesis

A tetrasaccharide linker sequence is required for GAG synthesis

1.00

Chondroitin sulfate/dermatan sulfate metabolism

0.54

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SDC4

Development FGFR signaling pathway

1 R&D Systems Pathway for SDC4

Wnt Signaling Pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SDC4

Transendothelial Migration of Leukocytes

1 Cell Signaling Technology (CST) Pathway for SDC4

Adhesion

1 GeneGo (Thomson Reuters) Pathway for SDC4

Development FGFR signaling pathway

2 BioSystems Pathways for SDC4

	Syndecan-4-mediated signaling events
	Proteogylcan syndecan-mediated signaling events

5/27 Reactome Pathways for SDC4 (see all 27)

	Diseases associated with visual transduction
	Chondroitin sulfate/dermatan sulfate metabolism
	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Visual phototransduction

3 Kegg Pathways (Kegg details for SDC4):

	ECM-receptor interaction
	Cell adhesion molecules (CAMs)
	Malaria

SDC4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SDC4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/101 Interacting proteins for SDC4 (P31431^{1, 2, 3} ENSP00000361818⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 101)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKCA	P17252¹^,³, ENSP00000284384⁴	EBI-3913237,EBI-1383528 I2D: score=2 STRING: ENSP00000284384
GIPC1	O14908²^,³, ENSP00000340698⁴	MINT-72943 I2D: score=4 STRING: ENSP00000340698
CASK	O14936³, ENSP00000367408⁴	I2D: score=2 STRING: ENSP00000367408
CXCR4	P61073³, ENSP00000386884⁴	I2D: score=2 STRING: ENSP00000386884
MDK	P21741³, ENSP00000352852⁴	I2D: score=2 STRING: ENSP00000352852

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001657	ureteric bud development	IEA	--
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006024	glycosaminoglycan biosynthetic process	TAS	--
GO:0006027	glycosaminoglycan catabolic process	TAS	--
GO:0008150	biological_process	ND	--

SDC4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SDC4

1 HMDB Compound for SDC4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Heparan sulfate	HHS 5 (see all 13)	9050-30-0	--

Search CenterWatch for drugs/clinical trials and news about SDC4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SDC4 gene:

NM_002999.3

Unigene Cluster for SDC4:

Syndecan 4

Hs.632267 [show with all ESTs]

Unigene Representative Sequence: BC030805

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000372733(uc002xnu.3 uc010zws.2) ENST00000537976

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDC4
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate SDC4 (see all 22):
		hsa-miR-142-3p hsa-miR-548k hsa-miR-16-1* hsa-miR-450b-3p hsa-miR-138-2* hsa-miR-764 hsa-miR-766 hsa-miR-3680

		SwitchGear 3'UTR luciferase reporter plasmid: SDC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDC4 (see all 7) OriGene shRNA RFP: SDC4 OriGene siRNA: SDC4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDC4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDC4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDC4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SDC4 (NM_002999)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDC4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDC4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDC4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDC4

Additional cDNA sequence:

AK222695.1 AK223243.1 AK303964.1 AK312507.1 BC030805.1 CR542045.1 CR542074.1 D13292.1

X67016.1

15 DOTS entries:

DT.452767 DT.95212585 DT.91958838 DT.100797956 DT.120819104 DT.95212580 DT.417846 DT.95212589

DT.100777096 DT.121639992 DT.91698455 DT.92442326 DT.97862180 DT.100033659 DT.92064138

24/300 AceView cDNA sequences (see all 300):

BP353030 AA329758 BC030805 BU624968 BQ689093 AA423819 BM989767 AW028728

CD364886 BX332639 BU727526 AI131546 CR542045 BM050667 AA002237 BX377561

BQ708981 AA313017 BM769629 AU118755 BX358362 AI027221 CA439231 T88923

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SDC4 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b
SP1:
SP2:					-

ECgene alternative splicing isoforms for SDC4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SDC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCATCTGTT

About this image

SDC4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Muscle Satellite Pool

Forelimb Muscle Satellite Cells

Skeletal Muscle

Limb

Hindlimb Muscle Satellite Pool

Hindlimb Muscle Satellite Cells

Skeletal Muscle

Cervical Muscle Satellite Pool

Muscle Satellite Cells

Skeletal Muscle

Lumbar Muscle Satellite Pool

Muscle Satellite Cells

Skeletal Muscle

Sacral Muscle Satellite Pool

Muscle Satellite Cells

Skeletal Muscle

Thoracic Muscle Satellite Pool

Muscle Satellite Cells

Skeletal Muscle

Bone

Endochondral Facial Bones

Bone

Bone

Bone

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

See SDC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SDC4

SOURCE GeneReport for Unigene cluster: Hs.632267

UniProtKB/Swiss-Prot: SDC4_HUMAN, P31431

Tissue specificity: Expressed in epithelial and fibroblastic cells

SABiosciences Custom PCR Arrays for SDC4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDC4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SDC4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDC4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDC4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDC4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SDC4 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SDC4¹	syndecan 4	63.26(n) 60.22(a)		419184 NM_001007869.1 NP_001007870.1
lizard (Anolis carolinensis)	Reptilia	SDC4⁶	--	48(a)	1 ↔ 1	4(142913934-142919639)
zebrafish (Danio rerio)	Actinopterygii	sdc4¹	syndecan 4	57.09(n) 48.5(a)		568593 NM_001048149.1 NP_001041614.1
fruit fly (Drosophila melanogaster)	Insecta	Sdc⁶	Syndecan	10(a)	1 → many	2R(17280111-17368680)
worm (Caenorhabditis elegans)	Secernentea	sdn-1⁶	Probable syndecan	14(a)	1 → many	X(10589718-10593274)

ENSEMBL Gene Tree for SDC4 (if available)
TreeFam Gene Tree for SDC4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SDC4 gene

SDC3² SDC2² SDC1²

1 SIMAP similar gene for SDC4 using alignment to 2 protein entries: SDC4_HUMAN (see all proteins):

SDC2

SDC4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SDC4
PGOHUM00000259702

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117775231^1,2	F,	--	43953491(+)	`CCCACA/GTCTAG`	1	--	ds500¹		1		EA	120
rs67068737^1,2	C,F,	--	43953510(+)	`CTGCCG/ACTCAG`	1	--	ds500¹		7		NA WA CSA EA	366
rs116292584^1,2		--	43953543(+)	`GCTGAC/TAGTTG`	1	--	ds500¹		0	--	--	--	--
rs2743357^1,2	H	--	43953603(+)	`ttatgA/Tgaaac`	1	--	ds500¹		4		NS EA	418
rs144527959^1,2		--	43953637(+)	`CTGACA/GCAAAG`	1	--	ds500¹		0	--	--	--	--
rs183875153^1,2		--	43953651(+)	`TTTGTA/GTTTGC`	1	--	ds500¹		0	--	--	--	--
rs188945177^1,2		--	43953906(+)	`ATGAAC/TGAAAA`	1	--	ds500¹		0	--	--	--	--
rs2743358^1,2	H	--	43954027(+)	`ACACAG/ACCCAA`	1	--	ut3¹ ese³		4		NS EA	416
rs7138^1,2	C,F,A,	--	43954058(-)	`GGGTCC/GTCTTC`	1	--	ut3¹ ese³		10		MN EA NA WA	2055
rs2853899^1,2	H	--	43954127(-)	`CCACCC/TTCCCT`	1	--	ut3¹ ese³		4		NS EA	402

HapMap Linkage Disequilibrium report for SDC4 (43953928 - 43977064 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SDC4: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SDC4 for disorders           About GeneDecksing

OMIM gene information: 600017    OMIM disorders: --

12 diseases for SDC4:    About MalaCards

kaposi's sarcoma bladder carcinoma sarcoma osteoarthritis

breast carcinoma melanoma atherosclerosis carcinoma

immunodeficiency hepatitis malaria neuronitis

Human Genome Epidemiology (HuGE) Navigator: SDC4 (6 documents)

Export disorders for SDC4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SDC4 gene, integrated from 9 sources (see all 104):
(articles sorted by number of sources associating them with SDC4)

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world of online information

Human ryudocan core protein: molecular cloning and characterization of the cDNA, and chromosomal localization of the gene. (PubMed id 7916598)^{1, 2, 3} Kojima T.... Saito H. (1993)
Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells. (PubMed id 1500433)^{1, 2, 3} David G....van den Berghe H. (1992)
Adhesion signaling by a novel mitotic substrate of src kinases. (PubMed id 16007225)^{1, 2} Bhatt A.S.... Moasser M.M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Solution structure of the dimeric cytoplasmic domain of syndecan-4. (PubMed id 11456484)^{1, 2} Shin J.... Oh E.-S. (2001)
Structural organization and promoter activity of the human ryudocan gene. (PubMed id 8797100)^{1, 2} Takagi A.... Saito H. (1996)
The altered expression of syndecan 4 in the uninvolved skin of venous leg ulcer patients may predispose to venous leg ulcer. (PubMed id 18638267)^{1, 9} Nagy N....Szell M. (2008)
Syndecan 4 regulates FGFR1 signaling in endothelial ce lls by directing macropinocytosis. (PubMed id 22569333)¹ Elfenbein A....Simons M. (2012)
Th1 cytokine-induced syndecan-4 shedding by airway smo oth muscle cells is dependent on mitogen-activated protein kinases. (PubMed id 22268118)¹ Tan X....Hughes J.M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6385	HGNC: 10661	AceView: SDC4	Ensembl:ENSG00000124145	euGenes: HUgn6385
ECgene: SDC4	Kegg: 6385	H-InvDB: SDC4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SDC4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SDC4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SDC4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SDC4 gene:
Search GeneIP for patents involving SDC4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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