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SDC4 Gene

protein-coding   GIFtS: 69
GCID: GC20M043953

Syndecan 4

(Previous names: syndecan 4 (amphiglycan, ryudocan))
  Search for SDC4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syndecan 41 2     amphiglycan2
Syndecan 4 (Amphiglycan, Ryudocan)1 2     Ryudocan Amphiglycan2
Syndecan Proteoglycan 41 2     syndecan-42
Ryudocan Core Protein2 3     Amphiglycan3
SYND42 3     

External Ids:    HGNC: 106611   Entrez Gene: 63852   Ensembl: ENSG000001241457   OMIM: 6000175   UniProtKB: P314313   

Export aliases for SDC4 gene to outside databases

Previous GC identifers: GC20M043682 GC20M044592 GC20M044639 GC20M043387 GC20M040695


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SDC4 Gene:
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a
receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan
proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SDC4 Gene:
SDC4 (syndecan 4) is a protein-coding gene. GO annotations related to this gene include cytoskeletal protein binding and fibronectin binding. An important paralog of this gene is SDC3.

UniProtKB/Swiss-Prot: SDC4_HUMAN, P31431
Function: Cell surface proteoglycan that bears heparan sulfate

Gene Wiki entry for SDC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the SDC4 gene promoter:
         AP-1   ATF-2   MyoD   c-Jun   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSDC4 promoter sequence
   Search Chromatin IP Primers for SDC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SDC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12

SDC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDC4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043953:  view genomic region     (about GC identifiers)

Start:
43,953,928 bp from pter      End:
43,977,064 bp from pter
Size:
23,137 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SDC4_HUMAN, P31431 (See protein sequence)
Recommended Name: Syndecan-4 precursor  
Size: 198 amino acids; 21642 Da
Subunit: Homodimer. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its
cytoplasmic domain) with NUDT16L1 (By similarity). Interacts with CDCP1 and SDCBP
4 PDB 3D structures from and Proteopedia for SDC4:
1EJP (3D)        1EJQ (3D)        1OBY (3D)        1YBO (3D)    
Secondary accessions: O00773 Q16833 Q53FN9 Q6FGN3
Alternative splicing: 2 isoforms:  P31431-1   P31431-2   (Soluble form, lacks the transmembrane domain)

Explore the universe of human proteins at neXtProt for SDC4: NX_P31431

Explore proteomics data for SDC4 at MOPED

Post-translational modifications: 

  • Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing.
    PMA-mediated shedding is inhibited by TIMP31
  • Glycosylation2 at Ser39, Ser61, Ser63, Ser97, Thr101, Ser117, Ser126
  • Modification sites at PhosphoSitePlus

  • See SDC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002990.2  
    ENSEMBL proteins: 
     ENSP00000361818   ENSP00000445353  
    Reactome Protein details: P31431

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    SDC4 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDC: Proteoglycans / Cell Surface : Syndecans

    3 InterPro protein domains:
     IPR001050 Syndecan
     IPR003585 Neurexin-like
     IPR027789 Syndecan/Neurexin_dom

    Graphical View of Domain Structure for InterPro Entry P31431

    ProtoNet protein and cluster: P31431

    2 Blocks protein domains:
    IPB001050 Syndecan
    IPB003585 Neurexin/syndecan/glycophorin C


    UniProtKB/Swiss-Prot: SDC4_HUMAN, P31431
    Similarity: Belongs to the syndecan proteoglycan family


    Find genes that share domains with SDC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SDC4_HUMAN, P31431
    Function: Cell surface proteoglycan that bears heparan sulfate

         Genatlas biochemistry entry for SDC4:
    syndecan 4,heparan sulfate proteoglycan 3 (22kDa),endothelial cell surface associated,cooperating with integrins
    in a Rho dependent manner in the assembly of focal adhesion and actin stress fibers

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005080protein kinase C binding IEA--
    GO:0005515protein binding IPI12571249
    GO:0008092cytoskeletal protein binding IEA--
    GO:0070053thrombospondin receptor activity IMP17879962
         
    Find genes that share ontologies with SDC4           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sdc4):
     cardiovascular system  cellular  embryogenesis  homeostasis/metabolism  mortality/aging 
     muscle  renal/urinary system 

    Find genes that share phenotypes with SDC4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SDC4: Sdc4tm1Goe Sdc4tm1Tmu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SDC4
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SDC4

    miRNA
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    Block miRNA regulation of human, mouse, rat SDC4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SDC4 (see all 22):
    hsa-miR-142-3p hsa-miR-548k hsa-miR-16-1* hsa-miR-450b-3p hsa-miR-138-2* hsa-miR-764 hsa-miR-766 hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidSDC4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SDC4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SDC4_HUMAN, P31431: Isoform 1: Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the
    ectodomain produces a soluble form (By similarity)
    SDC4_HUMAN, P31431: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    golgi apparatus4
    lysosome4
    vacuole4
    cytoskeleton2
    endoplasmic reticulum2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS1500433
    GO:0005925focal adhesion IEA--

    Find genes that share ontologies with SDC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SDC4 About   (see all 19)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.35
    Proteogylcan syndecan-mediated signaling events0.00
    Syndecan interactions0.00
    2MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    3Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    HS-GAG degradation0.39
    HS-GAG biosynthesis0.57
    4Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    Retinoid metabolism and transport0.44
    5Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53


    Find genes that share SuperPaths with SDC4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for SDC4
        Wnt Signaling Pathways
    VEGF - VEGF R2 Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SDC4
        Transendothelial Migration of Leukocytes

    1 Cell Signaling Technology (CST) Pathway for SDC4
        Adhesion

    1 GeneGo (Thomson Reuters) Pathway for SDC4
        Development FGFR signaling pathway

    2 BioSystems Pathways for SDC4
        Syndecan-4-mediated signaling events
    Proteogylcan syndecan-mediated signaling events

    2 Sino Biological Pathways for SDC4
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    5 Reactome Pathways for SDC4
        HS-GAG biosynthesis
    Retinoid metabolism and transport
    HS-GAG degradation
    A tetrasaccharide linker sequence is required for GAG synthesis
    Syndecan interactions


    3 Kegg Pathways  (Kegg details for SDC4):
        ECM-receptor interaction
    Cell adhesion molecules (CAMs)
    Proteoglycans in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SDC4
    Interactions:

        GeneGlobe Interaction Network for SDC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SDC4 (P314311, 2, 3 ENSP000003618184) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCAP172521, 3, ENSP000002843844EBI-3913237,EBI-1383528 I2D: score=2 STRING: ENSP00000284384
    GIPC1O149082, 3, ENSP000003406984MINT-72943 I2D: score=4 STRING: ENSP00000340698
    CASKO149363, ENSP000003674084I2D: score=2 STRING: ENSP00000367408
    CXCR4P610733, ENSP000003868844I2D: score=2 STRING: ENSP00000386884
    MDKP217413, ENSP000003528524I2D: score=2 STRING: ENSP00000352852
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    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0001657ureteric bud development IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0006027glycosaminoglycan catabolic process TAS--

    Find genes that share ontologies with SDC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SDC4

    1 HMDB Compound for SDC4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heparan sulfateHHS 5 (see all 13)9050-30-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SDC4 gene: 
    NM_002999.3  

    Unigene Cluster for SDC4:

    Syndecan 4
    Hs.632267  [show with all ESTs]
    Unigene Representative Sequence: BC030805
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372733(uc002xnu.3 uc010zws.2) ENST00000537976
    miRNA
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    hsa-miR-142-3p hsa-miR-548k hsa-miR-16-1* hsa-miR-450b-3p hsa-miR-138-2* hsa-miR-764 hsa-miR-766 hsa-miR-3680
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    Additional mRNA sequence: 

    AK222695.1 AK223243.1 AK303964.1 AK312507.1 BC030805.1 CR542045.1 CR542074.1 D13292.1 
    X67016.1 

    12 DOTS entries:

    DT.452767  DT.95212585  DT.100797956  DT.120819104  DT.95212580  DT.417846  DT.95212589  DT.100777096 
    DT.91698455  DT.92442326  DT.97862180  DT.100033659 

    Selected AceView cDNA sequences (see all 300):

    AU103151 AA423819 CD364886 BQ708981 CR542074 AW514394 BM769629 BX377561 
    BC030805 AA329758 BX400993 AI027221 T88923 BP353030 BU624968 AI074163 
    AW028728 BX332639 BM831837 CA439231 BM989767 AU118755 BI524082 BG149309 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SDC4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:              -                           


    ECgene alternative splicing isoforms for SDC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SDC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCATCTGTT
    SDC4 Expression
    About this image


    SDC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Endochondral Facial Bones
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Satellite Cells Lumbar Muscle Satellite Pool
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Testis (Reproductive System)
             Seminiferous Tubules
    SDC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SDC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632267

    UniProtKB/Swiss-Prot: SDC4_HUMAN, P31431
    Tissue specificity: Expressed in epithelial and fibroblastic cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SDC4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sdc41 , 5 syndecan 41, 5 81.52(n)1
    82.38(a)1
      2 (85.16 cM)5
    209711  NM_011521.21  NP_035651.11 
     1644242475 
    chicken
    (Gallus gallus)
    Aves SDC41 syndecan 4 63.26(n)
    60.22(a)
      419184  NM_001007869.1  NP_001007870.1 
    lizard
    (Anolis carolinensis)
    Reptilia SDC46
    syndecan 4
    54(a)
    1 ↔ 1
    4(142913934-142920374)
    zebrafish
    (Danio rerio)
    Actinopterygii sdc41 syndecan 4 57.09(n)
    48.5(a)
      568593  NM_001048149.1  NP_001041614.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sdc6
    Syndecan
    12(a)
    1 → many
    2R(17280111-17368680)
    worm
    (Caenorhabditis elegans)
    Secernentea sdn-16
    Protein SDN-1, isoform b (sdn-1) mRNA, complete cd...
    18(a)
    1 → many
    X(10589780-10593334) WBGene00004749


    ENSEMBL Gene Tree for SDC4 (if available)
    TreeFam Gene Tree for SDC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SDC4 gene
    SDC32  SDC22  SDC12  
    5 SIMAP similar genes for SDC4 using alignment to 2 protein entries:     SDC4_HUMAN (see all proteins):
    R32    R34    SDC2    SDC4-ROS1_S2    SDC4-ROS1_S4

    Find genes that share paralogs with SDC4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SDC4
    PGOHUM00000259702


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SDC4 (see all 651)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852987661,2
    --43949510(+) ATGCTC/TCCCTA 1 -- us2k10--------
    rs1173010051,2
    C,F--43949558(+) TGCCAG/TAATAA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1177752311,2
    C,F--43953491(+) CCCACA/GTCTAG 1 -- ds50011Minor allele frequency- G:0.02EA 120
    rs670687371,2
    C,F--43953510(+) CTGCCG/ACTCAG 1 -- ds50017Minor allele frequency- A:0.20NA WA CSA EA 366
    rs1162925841,2
    --43953543(+) GCTGAC/TAGTTG 1 -- ds50010--------
    rs27433571,2
    H--43953603(+) ttatgA/Tgaaac 1 -- ds50014Minor allele frequency- T:0.00NS EA 418
    rs1445279591,2
    --43953637(+) CTGACA/GCAAAG 1 -- ds50010--------
    rs1838751531,2
    --43953651(+) TTTGTA/GTTTGC 1 -- ds50010--------
    rs1889451771,2
    --43953906(+) ATGAAC/TGAAAA 1 -- ds50010--------
    rs27433581,2
    H--43954027(+) ACACAG/ACCCAA 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 416

    HapMap Linkage Disequilibrium report for SDC4 (43953928 - 43977064 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SDC4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SDC4
    DNA2.0 Custom Variant and Variant Library Synthesis for SDC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600017    OMIM disorders: --


    Find genes that share disorders with SDC4           About GenesLikeMe

    Genetic Association Database (GAD): SDC4
    Human Genome Epidemiology (HuGE) Navigator: SDC4 (6 documents)

    Export disorders for SDC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SDC4 gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with SDC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ryudocan core protein: molecular cloning and characterization of the cDNA, and chromosomal localization of the gene. (PubMed id 7916598)1, 2, 3 Kojima T.... Saito H. (Biochem. Biophys. Res. Commun. 1993)
    2. Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells. (PubMed id 1500433)1, 2, 3 David G....van den Berghe H. (J. Cell Biol. 1992)
    3. The altered expression of syndecan 4 in the uninvolved skin of venous leg ulcer patients may predispose to venous leg ulcer. (PubMed id 18638267)1, 4, 9 Nagy N....SzAcll M. (Wound Repair Regen 2008)
    4. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    5. Genome-wide association analysis identifies three psoriasis susceptibility loci. (PubMed id 20953189)1, 4 Stuart P.E....Elder J.T. (Nat. Genet. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Adhesion signaling by a novel mitotic substrate of src kinases. (PubMed id 16007225)1, 2 Bhatt A.S.... Moasser M.M. (Oncogene 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    10. Solution structure of the dimeric cytoplasmic domain of syndecan-4. (PubMed id 11456484)1, 2 Shin J.... Oh E.-S. (Biochemistry 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6385 HGNC: 10661 AceView: SDC4 Ensembl:ENSG00000124145 euGenes: HUgn6385
    ECgene: SDC4 Kegg: 6385 H-InvDB: SDC4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SDC4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SDC4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SDC4 gene:
    Search GeneIP for patents involving SDC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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