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SDC3 Gene

protein-coding   GIFtS: 65
GCID: GC01M031342

Syndecan 3

(Previous name: syndecan 3 (N-syndecan))
  See SDC3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syndecan 31 2     N-syndecan2
SYND32 3 5     Syndecan Neural Type2
Syndecan Proteoglycan 31 2     syndecan-32
SDCN2 5     KIAA04683
Syndecan 3 (N-Syndecan)1     

External Ids:    HGNC: 106601   Entrez Gene: 96722   Ensembl: ENSG000001625127   OMIM: 1863575   UniProtKB: O750563   

Export aliases for SDC3 gene to outside databases

Previous GC identifers: GC01M031136 GC01M030326 GC01M030768 GC01M030844 GC01M031011 GC01M029448


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SDC3 Gene:
The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the
organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell
surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity.
(provided by RefSeq, Oct 2009)

GeneCards Summary for SDC3 Gene:
SDC3 (syndecan 3) is a protein-coding gene. Diseases associated with SDC3 include obesity, association with, and obesity. GO annotations related to this gene include cytoskeletal protein binding. An important paralog of this gene is SDC4.

UniProtKB/Swiss-Prot: SDC3_HUMAN, O75056
Function: Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the
organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell
surface in a sugar-dependent mechanism

Gene Wiki entry for SDC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the SDC3 gene promoter:
         c-Fos   AP-1   Lmo2   MyoD   NRF-2   c-Myb   c-Jun   ATF6   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SDC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SDC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.2   Ensembl cytogenetic band:  1p35.2   HGNC cytogenetic band: 1p35.2

SDC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDC3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M031342:  view genomic region     (about GC identifiers)

Start:
31,342,313 bp from pter      End:
31,381,608 bp from pter
Size:
39,296 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SDC3_HUMAN, O75056 (See protein sequence)
Recommended Name: Syndecan-3  
Size: 442 amino acids; 45497 Da
Subunit: Interacts with TIAM1
Sequence caution: Sequence=BAA32313.2; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: Q5T1Z6 Q5T1Z7 Q96CT3 Q96PR8

Explore the universe of human proteins at neXtProt for SDC3: NX_O75056

Explore proteomics data for SDC3 at MOPED

Post-translational modifications: 

  • O-glycosylated within the Thr/Ser-rich region which could interact with lectin domains on other molecules
    (Probable)1
  • Glycosylation2 at Ser80, Ser82, Ser84, Ser91, Ser250, Thr251, Thr253, Thr264, Thr265, Ser314,
                                 Ser344, Thr349, Ser367
  • Modification sites at PhosphoSitePlus

  • See SDC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055469.3  
    ENSEMBL proteins: 
     ENSP00000338346   ENSP00000344468  
    Reactome Protein details: O75056

    SDC3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SDC3

     
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    SDC3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    SDC3 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDC: Proteoglycans / Cell Surface : Syndecans

    3 InterPro protein domains:
     IPR001050 Syndecan
     IPR003585 Neurexin-like
     IPR027789 Syndecan/Neurexin_dom

    Graphical View of Domain Structure for InterPro Entry O75056

    ProtoNet protein and cluster: O75056

    2 Blocks protein domains:
    IPB001050 Syndecan
    IPB003585 Neurexin/syndecan/glycophorin C


    UniProtKB/Swiss-Prot: SDC3_HUMAN, O75056
    Similarity: Belongs to the syndecan proteoglycan family


    Find genes that share domains with SDC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SDC3_HUMAN, O75056
    Function: Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the
    organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell
    surface in a sugar-dependent mechanism

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008092cytoskeletal protein binding IEA--
         
    Find genes that share ontologies with SDC3           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sdc3):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism 

    Find genes that share phenotypes with SDC3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sdc3tm1Rau for SDC3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SDC3
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    miRNA
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    miRTarBase miRNAs that target SDC3:
    hsa-mir-335-5p (MIRT018892), hsa-mir-26b-5p (MIRT030232)

    Block miRNA regulation of human, mouse, rat SDC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SDC3 (see all 51):
    hsa-miR-330-5p hsa-miR-24-1* hsa-miR-513a-5p hsa-miR-25 hsa-let-7a-2* hsa-miR-486-3p hsa-miR-138-2* hsa-miR-650
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat SDC3

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    Sino Biological Human cDNA Clone for SDC3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SDC3_HUMAN, O75056: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    lysosome4
    plasma membrane4
    vacuole4
    extracellular2
    cytoskeleton1
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ISS--
    GO:0016021integral component of membrane IEA--
    GO:0043202lysosomal lumen TAS--

    Find genes that share ontologies with SDC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SDC3 About   (see all 17)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.35
    Proteogylcan syndecan-mediated signaling events0.00
    Syndecan interactions0.00
    2MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    3Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    HS-GAG degradation0.39
    HS-GAG biosynthesis0.57
    4Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    Retinoid metabolism and transport0.44
    5Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53


    Find genes that share SuperPaths with SDC3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for SDC3
        Wnt Signaling Pathways
    Articular Cartilage Extracellular Matrix
    VEGF - VEGF R2 Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SDC3
        Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for SDC3
        Neurophysiological process Receptor-mediated axon growth repulsion

    2 BioSystems Pathways for SDC3
        Syndecan-3-mediated signaling events
    Proteogylcan syndecan-mediated signaling events

    2 Sino Biological Pathways for SDC3
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    5 Reactome Pathways for SDC3
        HS-GAG biosynthesis
    Retinoid metabolism and transport
    HS-GAG degradation
    A tetrasaccharide linker sequence is required for GAG synthesis
    Syndecan interactions


    1 Kegg Pathway  (Kegg details for SDC3):
        Cell adhesion molecules (CAMs)

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SDC3
    Interactions:

        GeneGlobe Interaction Network for SDC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SDC3 (O750563 ENSP000003444684) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232575P074373, ENSP000004100714I2D: score=2 STRING: ENSP00000410071
    ENSG00000183311P074373I2D: score=2 
    ENSG00000224156P074373I2D: score=2 
    ENSG00000227739P074373I2D: score=2 
    ENSG00000229684P074373I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0006027glycosaminoglycan catabolic process TAS--
    GO:0007603phototransduction, visible light TAS--

    Find genes that share ontologies with SDC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SDC3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SDC3 gene: 
    NM_014654.3  

    Unigene Cluster for SDC3:

    Syndecan 3
    Hs.158287  [show with all ESTs]
    Unigene Representative Sequence: NM_014654
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336798(uc001bsd.2 uc001bse.2) ENST00000339394 ENST00000471567
    ENST00000487984
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SDC3 (see all 51):
    hsa-miR-330-5p hsa-miR-24-1* hsa-miR-513a-5p hsa-miR-25 hsa-let-7a-2* hsa-miR-486-3p hsa-miR-138-2* hsa-miR-650
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SDC3
      QuantiTect SYBR Green Assays in human, mouse, rat SDC3
      QuantiFast Probe-based Assays in human, mouse, rat SDC3

    Additional mRNA sequence: 

    AF248634.1 AK295698.1 AL049426.1 

    12 DOTS entries:

    DT.97822059  DT.95239940  DT.444173  DT.121338024  DT.95239945  DT.75147740  DT.92457868  DT.97815964 
    DT.100723844  DT.100800280  DT.100821837  DT.121338008 

    Selected AceView cDNA sequences (see all 240):

    BE874804 BQ880076 BQ221140 BU540955 BQ677150 AW016338 BX095994 AU280274 
    F11324 BQ877294 AA349753 BM712824 BX643294 CB156280 AW117922 T09287 
    BM685271 BM676907 CR610672 AI950871 BI333107 AA054013 BQ233735 BM714004 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SDC3 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:        -     -     -     -                                   -                           
    SP2:              -     -     -                                                               
    SP3:                                                                                          
    SP4:                                                              -                           
    SP5:                                      -                                                   


    ECgene alternative splicing isoforms for SDC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SDC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAAACCT
    SDC3 Expression
    About this image


    SDC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Thalamus
             Oligodendrocyte progenitor cells
     
     Tooth (Integumentary System)    fully expand to see all 5 entries
             Odontoblasts Dentin
             Dentin
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Satellite Cells Lumbar Muscle Satellite Pool
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Spinal Cord (Nervous System)
             Oligodendrocyte progenitor cells
    SDC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SDC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158287

    UniProtKB/Swiss-Prot: SDC3_HUMAN, O75056
    Tissue specificity: Expressed in the nervous system, the adrenal gland, and the spleen

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SDC3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sdc31 , 5 syndecan 31, 5 83.33(n)1
    85.53(a)1
      4 (63.63 cM)5
    209701  NM_011520.31  NP_035650.21 
     1307925375 
    chicken
    (Gallus gallus)
    Aves SDC31 syndecan 3 65.43(n)
    59.95(a)
      396343  NM_205383.1  NP_990714.1 
    lizard
    (Anolis carolinensis)
    Reptilia SDC36
    syndecan 3
    50(a)
    1 ↔ 1
    GL343563.1(93505-116287)
    African clawed frog
    (Xenopus laevis)
    Amphibia sdc3-A2 syndecan 3 (N-syndecan) 75.04(n)    U41761.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.281572 Transcribed sequence with weak similarity to protein more 77.29(n)    57092430 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sdc6
    Syndecan
    18(a)
    1 → many
    2R(17280111-17368680)
    worm
    (Caenorhabditis elegans)
    Secernentea sdn-16
    Protein SDN-1, isoform b (sdn-1) mRNA, complete cd...
    23(a)
    1 → many
    X(10589780-10593334) WBGene00004749


    ENSEMBL Gene Tree for SDC3 (if available)
    TreeFam Gene Tree for SDC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SDC3 gene
    SDC42  SDC22  SDC12  
    1 SIMAP similar gene for SDC3 using alignment to 3 protein entries:     SDC3_HUMAN (see all proteins):
    SDC2

    Find genes that share paralogs with SDC3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SDC3 (see all 935)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22824401,2,,4
    C,F,O,Hpathogenic131347320(-) AGACAC/TAGCCA 2 T I mis1 ese321Minor allele frequency- T:0.16EA NA NS WA EU 9777
    rs24911321,2,,4
    C,F,Hpathogenic131349647(+) CCGTAC/G/TGCCAG 2 I V mis1 ese315NA NS EA CSA EU 5198
    rs795781991,2
    F--31341903(+) CCAGAG/CTCAGC 1 -- ds50011Minor allele frequency- C:0.01EA 120
    rs1167623061,2
    F--31341951(+) TCAGAC/GTTAAA 1 -- ds50011Minor allele frequency- G:0.02WA 118
    rs1465369671,2
    --31341966(+) ATCTCA/GTCTCG 1 -- ds50010--------
    rs1871978431,2
    --31341976(+) GTCTCA/GGCTGC 1 -- ds50010--------
    rs1391019291,2
    --31342050(+) GGGTGA/TACCAC 1 -- ds50010--------
    rs785472461,2
    C,F--31342124(+) GGCTCC/TGTGGT 1 -- ds50013Minor allele frequency- T:0.10NA CSA WA 122
    rs107110241,2
    C,F--31342368(+) GTGTTA/-AAAAA 1 -- ut313Minor allele frequency- -:0.50NA CSA 6
    rs1393938861,2
    C--31342371(+) TAAAA-/AACAAACA 1 -- cds10--------

    HapMap Linkage Disequilibrium report for SDC3 (31342313 - 31381608 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SDC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2244846CNV Deletion18987734
    esv2746264CNV Deletion23290073
    esv2746275CNV Deletion23290073
    esv2746253CNV Deletion23290073
    nsv160596CNV Loss16902084
    nsv160199CNV Loss16902084
    nsv461006CNV Loss19166990
    nsv519204CNV Gain19592680
    nsv470707CNV Gain18288195

    Human Gene Mutation Database (HGMD): SDC3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SDC3
    DNA2.0 Custom Variant and Variant Library Synthesis for SDC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186357   
    OMIM disorders: 601665  
    2 diseases for SDC3:    
    About MalaCards
    obesity, association with    obesity


    Find genes that share disorders with SDC3           About GenesLikeMe

    Genetic Association Database (GAD): SDC3
    Human Genome Epidemiology (HuGE) Navigator: SDC3 (3 documents)

    Export disorders for SDC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SDC3 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with SDC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human syndecan-3. (PubMed id 11527150)1, 2, 3 Berndt C.... Reina M. (J. Cell. Biochem. 2001)
    2. Role of syndecan-3 polymorphisms in obesity and female hyperandrogenism. (PubMed id 19820907)1, 4, 9 SchA1ring A.N....GAPtte M. (J. Mol. Med. 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Positive association of obesity with single nucleotide polymorphisms of syndecan 3 in the Korean population. (PubMed id 17018662)1, 4 Ha E....Kim J.W. (J. Clin. Endocrinol. Metab. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (DNA Res. 1997)
    7. Phosphorylation of recombinant N-syndecan (syndecan 3) core protein. (PubMed id 9388509)1, 2 Asundi V.K. and Carey D.J. (Biochem. Biophys. Res. Commun. 1997)
    8. Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan. (PubMed id 1556152)1, 3 Carey D.J....Cizmeci-Smith G. (J. Cell Biol. 1992)
    9. The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics. (PubMed id 23395182)2 Liu X.... Fuentes E.J. (Structure 2013)
    10. Prognostic significance of the expression of GFRI+1, GFRI+3 and syndecan-3, proteins binding ARTEMIN, in mammary carcinoma. (PubMed id 23351331)1 Wu Z.S....Lobie P.E. (BMC Cancer 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9672 HGNC: 10660 AceView: SDC3 Ensembl:ENSG00000162512 euGenes: HUgn9672
    ECgene: SDC3 Kegg: 9672 H-InvDB: SDC3

    (According to HUGE)
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    HUGE: KIAA0468

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SDC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SDC3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SDC3 gene:
    Search GeneIP for patents involving SDC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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