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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SDC2 Gene

protein-coding GIFtS: 67
GCID: GC08P097575

syndecan 2

(Previous names: heparan sulfate proteoglycan 1, cell surface-associated...)
(Previous symbols: HSPG, HSPG1)

Explore 38 diseases affiliated with
SDC2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Syndecan 2¹ ²		Heparan Sulfate Proteoglycan Core Protein² ³
HSPG1¹ ² ³ ⁵		Cell Surface-Associated Heparan Sulfate Proteoglycan 1²
HSPG¹ ² ³		Syndecan Proteoglycan 2²
SYND2¹ ² ³		Syndecan-2¹
CD362¹ ²		Fibroglycan³
Fibroglycan³		CD362 Antigen³
Heparan Sulfate Proteoglycan 1, Cell Surface-Associated¹ ²

External Ids:	HGNC: 10659¹	Entrez Gene: 6383²	Ensembl: ENSG00000169439⁷	OMIM: 142460⁵	UniProtKB: P34741³

Export aliases for SDC2 gene to outside databases

Previous GC identifers: GC08P096514 GC08P097579 GC08P097174 GC08P097462 GC08P092711

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SDC2:

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the

syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and

syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an

integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its

receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor

types. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SDC2_HUMAN, P34741

Function: Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity)

Gene Wiki entry for SDC2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SDC2 gene promoter:
Bach1 AhR NRSF form 1 Nkx2-5 E4BP4 LCR-F1 Evi-1 Arnt MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SDC2 promoter sequence

Search SABiosciences Chromatin IP Primers for SDC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22-q23 Ensembl cytogenetic band: 8q22.1 HGNC cytogenetic band: 8q22-q23

SDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDC2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P097575: view genomic region (about GC identifiers)

Start:	97,505,579 bp from pter	End:	97,624,037 bp from pter
Size:	118,459 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SDC2_HUMAN, P34741 (See protein sequence)

Recommended Name: Syndecan-2 precursor

Size: 201 amino acids; 22160 Da

Subunit: Interacts (via cytoplasmic domain) with SARM1 (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

Sequence caution: Sequence=AAA52701.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B3KQA3 Q6PIS6 Q9H6V1

Explore the universe of human proteins at neXtProt for SDC2: NX_P34741

Post-translational modifications:

O-glycosylated with core 1 or possibly core 8 glycans. Contains heparan sulfate¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P34741

SDC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002989.2

ENSEMBL proteins:

ENSP00000307046 ENSP00000429045 ENSP00000427784 ENSP00000428256 ENSP00000429121

ENSP00000429662 ENSP00000441453

Reactome Protein details: P34741
Human Recombinant Protein Products:

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	Novus Biologicals SDC2 Proteins Novus Biologicals SDC2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SDC2

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005796	Golgi lumen	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	--	--

SDC2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SDC2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SDC2 for domains About GeneDecksing

2 InterPro domains/families:

IPR003585 Neurexin-like

IPR001050 Syndecan

Graphical View of Domain Structure for InterPro Entry P34741

ProtoNet protein and cluster: P34741

2 Blocks protein families:

IPB001050 Syndecan

IPB003585 Neurexin/syndecan/glycophorin C

UniProtKB/Swiss-Prot: SDC2_HUMAN, P34741

Similarity: Belongs to the syndecan proteoglycan family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SDC2_HUMAN, P34741

Function: Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity)

Genatlas biochemistry entry for SDC2:

syndecan 2,heparan sulfate proteoglycan 1 (48kDa and 90kDa),cell surface-associated,lung,fibroblast,involved in a

translocation t(X,8)(p22.13-q22.1) in a patient with autism and multiple exostoses

miRNA Products:		OriGene 3'-UTR Clone: SDC2 Browse MicroRNA Expression Plasmids
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		hsa-miR-21* hsa-miR-607 hsa-miR-429 hsa-miR-199a-3p hsa-miR-25 hsa-miR-200a hsa-miR-1245 hsa-miR-218

		SwitchGear 3'UTR luciferase reporter plasmid: SDC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SDC2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDC2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11356864
GO:0008092	cytoskeletal protein binding	IEA	--
GO:0030165	PDZ domain binding	IPI	18256285

SDC2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/16 pathways (see all 16)
MPS VI - Maroteaux-Lamy syndrome	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIID - Sanfilippo syndrome D	1.00
MPS I - Hurler syndrome	1.00	MPS IX - Natowicz syndrome	1.00
Mucopolysaccharidoses	1.00	MPS II - Hunter syndrome	1.00

HS-GAGs translocate to the lysosome for degradation

	HS-GAGs translocate to the lysosome for degradation	1.00			HS-GAG degradation	0.57
	Some HSPGs are secreted to the plasma membrane	1.00			Proteogylcan syndecan-mediated signaling events	0.33

Retinoid metabolism and transport

	Retinoid metabolism and transport	1.00			Diseases associated with visual transduction	0.73
	Visual phototransduction	0.74

Development FGFR signaling pathway

Development FGFR signaling pathway

1.00

Development_FGFR signaling pathway

0.98

A tetrasaccharide linker sequence is required for GAG synthesis

A tetrasaccharide linker sequence is required for GAG synthesis

1.00

Chondroitin sulfate/dermatan sulfate metabolism

0.54

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for SDC2

	Cell adhesion ECM remodeling
	Development FGFR signaling pathway

1 R&D Systems Pathway for SDC2

Wnt Signaling Pathway

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SDC2

	Inhibition of Angiogenesis by TSP1
	Inhibition of Matrix Metalloproteinases
	Transendothelial Migration of Leukocytes

2 GeneGo (Thomson Reuters) Pathways for SDC2

	Cell adhesion ECM remodeling
	Development FGFR signaling pathway

4 BioSystems Pathways for SDC2

	TGF-beta Receptor Signaling Pathway
	FGF signaling pathway
	Syndecan-2-mediated signaling events
	Proteogylcan syndecan-mediated signaling events

5/27 Reactome Pathways for SDC2 (see all 27)

	Diseases associated with visual transduction
	Chondroitin sulfate/dermatan sulfate metabolism
	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Visual phototransduction

3 Kegg Pathways (Kegg details for SDC2):

	ECM-receptor interaction
	Cell adhesion molecules (CAMs)
	Malaria

SDC2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SDC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/133 Interacting proteins for SDC2 (P34741^{1, 2, 3} ENSP00000307046⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 133)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CASK	O14936¹^,²^,³, ENSP00000367408⁴	EBI-1172957,EBI-1215506 MINT-14973 MINT-14974 MINT-58223 MINT-14972 I2D: score=5 STRING: ENSP00000367408
NF1	P21359¹^,³, ENSP00000351015⁴	EBI-1172957,EBI-1172917 I2D: score=3 STRING: ENSP00000351015
SDCBP	O00560³, ENSP00000260130⁴	I2D: score=3 STRING: ENSP00000260130
EPHB2	P29323³, ENSP00000363763⁴	I2D: score=2 STRING: ENSP00000363763
EZR	P15311³, ENSP00000338934⁴	I2D: score=2 STRING: ENSP00000338934

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006024	glycosaminoglycan biosynthetic process	TAS	--
GO:0006027	glycosaminoglycan catabolic process	TAS	--
GO:0008150	biological_process	ND	--

SDC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SDC2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SDC2

1 HMDB Compound for SDC2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Heparan sulfate	HHS 5 (see all 13)	9050-30-0	--

1 DrugBank Compound for SDC2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Sargramostim	Colony-stimulating factor (see all 5)	83869-56-1	target	agonist	10734053 17139284 17016423

1 Novoseek chemical compound relationship for SDC2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heparan sulfate	74.8	4	15054905 (1), 12761845 (1), 15554942 (1), 8537400 (1)

Search CenterWatch for drugs/clinical trials and news about SDC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SDC2 gene:

NM_002998.3

Unigene Cluster for SDC2:

Syndecan 2

Hs.1501 [show with all ESTs]

Unigene Representative Sequence: BC030133

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302190(uc003yhv.1 uc011lgu.1) ENST00000520233 ENST00000519587

ENST00000518385 ENST00000522911 ENST00000519914 ENST00000521590 ENST00000523877

ENST00000545117

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		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate SDC2 (see all 54):
		hsa-miR-21* hsa-miR-607 hsa-miR-429 hsa-miR-199a-3p hsa-miR-25 hsa-miR-200a hsa-miR-1245 hsa-miR-218

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Additional cDNA sequence:

AK025488.1 AK074530.1 AK097839.1 AK130131.1 AK298643.1 AK298939.1 AK300067.1 BC030133.2

BC049836.1 J04621.1

17 DOTS entries:

DT.318538 DT.100823371 DT.100823364 DT.95156202 DT.100823363 DT.100823369 DT.121482345 DT.100644039

DT.100675643 DT.121482311 DT.91764066 DT.91764072 DT.91837226 DT.95156197 DT.121482328 DT.91764069

DT.92014938

24/382 AceView cDNA sequences (see all 382):

H64347 AI337354 CB161866 BU154320 AA122057 AW301666 BQ716567 BU629078

BF061447 BM834669 BQ575736 AK130131 BQ721382 AK074530 CA448604 AA043662

CR596137 AA114891 BU625124 CA419078 T68006 BQ719666 H81688 CB162695

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SDC2 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6a	·	6b
SP1:									-
SP2:							-		-
SP3:

ECgene alternative splicing isoforms for SDC2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SDC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCCTAATA

About this image

SDC2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Endochondral Facial Bones

Bone

Thoracic Rib

Bone

Cartilage

Meckel's Cartilage

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 8 LifeMap Cells

Name

Category

mK3 (Cell line)

Kidney

mK4 (Cell line)

Kidney

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See SDC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SDC2

SOURCE GeneReport for Unigene cluster: Hs.1501

SABiosciences Custom PCR Arrays for SDC2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDC2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SDC2 gene from 7/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sdc2^{1 , 5}	syndecan 2^{1, 5}	84.41(n)¹ 84.08(a)¹		15 (13.74 cM)⁵ 15529¹ NM_008304.2¹ NP_032330.1¹ 32920723⁵
chicken (Gallus gallus)	Aves	SDC2¹	syndecan 2	74.63(n) 72.64(a)		374102 NM_001001462.1 NP_001001462.1
lizard (Anolis carolinensis)	Reptilia	SDC2⁶	--	64(a)	1 ↔ 1	4(20103490-20110825)
African clawed frog (Xenopus laevis)	Amphibia	sdc2-A-prov²	syndecan 2	81.16(n)		BC041490.1
zebrafish (Danio rerio)	Actinopterygii	sdc2²	syndecan 2	78.47(n)		282667 AF262048.1
fruit fly (Drosophila melanogaster)	Insecta	Sdc⁶	Syndecan	12(a)	1 → many	2R(17280111-17368680)
worm (Caenorhabditis elegans)	Secernentea	sdn-1⁶	Probable syndecan	19(a)	1 → many	X(10589718-10593274)

ENSEMBL Gene Tree for SDC2 (if available)
TreeFam Gene Tree for SDC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SDC2 gene

SDC3² SDC4² SDC1²

2 SIMAP similar genes for SDC2 using alignment to 4 protein entries: SDC2_HUMAN (see all proteins):

SDC4 SDC3

SDC2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35483553^1,2	C,F	--	97503892(+)	`CTGGCG/AAGTAG`	1	--	us2k¹		3		NA	6
rs3943731^1,2	H	--	97504030(+)	`TCCATC/TTTAAA`	1	--	us2k¹		4		NS EA	418
rs184679610^1,2		--	97504085(+)	`TTTGGA/GAGGCT`	1	--	us2k¹		0	--	--	--	--
rs140126000^1,2		--	97504119(+)	`CAAGAA/GTTTGA`	1	--	us2k¹		0	--	--	--	--
rs116549524^1,2	F,	--	97504256(+)	`GAGGTA/CGAGGC`	1	--	us2k¹		1		WA	118
rs11463010^1,2	C	--	97504313(+)	`AAAAAA/-AAAAA`	1	--	us2k¹ trp³		1		NA	2
rs143809445^1,2		--	97504339(+)	`AAAGGC/TTGTGG`	1	--	us2k¹		0	--	--	--	--
rs146440357^1,2		--	97504369(+)	`AGTGGA/GGCCCA`	1	--	us2k¹		0	--	--	--	--
rs115856018^1,2		--	97504404(+)	`TGTCTG/ATGGAA`	1	--	us2k¹		1		WA	118
rs74591831^1,2	F,	--	97504606(+)	`TCTCCA/TGTTAA`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for SDC2 (97505579 - 97624037 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for SDC2
5 CNVs: 100429 95583 62828 59500 65204
2 Indels: 82699 95584

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SDC2 for disorders           About GeneDecksing

OMIM gene information: 142460    OMIM disorders: --

20/38 diseases for SDC2 (see all 38):    About MalaCards

langer-giedion syndrome fibrodysplasia ossificans progressiva abdominal aortic aneurysm aortic aneurysm

short stature esophageal squamous cell carcinoma squamous cell carcinoma exostoses

acute myeloid leukemia myeloid leukemia kaposi's sarcoma amyloidosis

neurofibromatosis nephropathy proteinuria chondrosarcoma

sarcoma colon carcinoma alzheimer's disease esophagitis

1 disease from the University of Copenhagen DISEASES database for SDC2:

Alzheimer's disease

1 Novoseek disease relationship for SDC2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	4	19288017 (1)

Genetic Association Database (GAD): SDC2
Human Genome Epidemiology (HuGE) Navigator: SDC2 (9 documents)

Export disorders for SDC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SDC2 gene, integrated from 9 sources (see all 129):
(articles sorted by number of sources associating them with SDC2)

Utopia: connect your pdf to the dynamic
world of online information

Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Co-inheritance of specific genotypes of HSPG and ApoE gene increases risk of type 2 diabetic nephropathy. (PubMed id 14674716)^{1, 4} Liu L....Li J. (2003)
The heparan sulfate proteoglycan gene polymorphism: association with type 2 diabetic nephropathy in Chinese. (PubMed id 12708751)^{1, 4} Liu L....Li J. (2003)
Syndecan-2 is involved in the mitogenic activity and signaling of granulocyte-macrophage colony-stimulating factor in osteoblasts. (PubMed id 10734053)^{1, 7} Modrowski D....Marie P.J. (2000)
Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development. (PubMed id 8187643)^{1, 3} David G....Van den Berghe H. (1993)
Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts. (PubMed id 2523388)^{1, 2} Marynen P.... David G. (1989)
Prognostic significance of altered expression of SDC2 and CYR61 in esophageal squamous cell carcinoma. (PubMed id 19288017)^{1, 9} Huang X....Li E.M. (2009)
Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene. (PubMed id 9259269)^{1, 9} Ishikawa-Brush Y....Monaco A.P. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6383	HGNC: 10659	AceView: SDC2	Ensembl:ENSG00000169439	euGenes: HUgn6383
ECgene: SDC2	Kegg: 6383	H-InvDB: SDC2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SDC2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SDC2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SDC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SDC2 gene:
Search GeneIP for patents involving SDC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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