Aliases for SDC2 Gene
External Ids for SDC2 Gene
Previous HGNC Symbols for SDC2 Gene
Previous GeneCards Identifiers for SDC2 Gene
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
GeneCards Summary for SDC2 Gene
SDC2 (Syndecan 2) is a Protein Coding gene. Diseases associated with SDC2 include Trichorhinophalangeal Syndrome, Type I and Chronic Cholangitis. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways and Defective B4GALT7 causes EDS, progeroid type. GO annotations related to this gene include PDZ domain binding and cytoskeletal protein binding. An important paralog of this gene is SDC4.
UniProtKB/Swiss-Prot for SDC2 Gene
Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).