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Aliases for SDC2 Gene

Aliases for SDC2 Gene

  • Syndecan 2 2 3 5
  • Heparan Sulfate Proteoglycan 1, Cell Surface-Associated 2 3
  • Heparan Sulfate Proteoglycan Core Protein 3 4
  • Syndecan Proteoglycan 2 2 3
  • Fibroglycan 3 4
  • HSPG1 3 4
  • SYND2 3 4
  • HSPG 3 4
  • Cell Surface-Associated Heparan Sulfate Proteoglycan 1 3
  • CD362 Antigen 4
  • CD362 3

External Ids for SDC2 Gene

Previous HGNC Symbols for SDC2 Gene

  • HSPG
  • HSPG1

Previous GeneCards Identifiers for SDC2 Gene

  • GC08P097579
  • GC08P097174
  • GC08P097462
  • GC08P097575
  • GC08P092711

Summaries for SDC2 Gene

Entrez Gene Summary for SDC2 Gene

  • The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]

GeneCards Summary for SDC2 Gene

SDC2 (Syndecan 2) is a Protein Coding gene. Diseases associated with SDC2 include Leri Pleonosteosis and Trichorhinophalangeal Syndrome, Type I. Among its related pathways are Glycosaminoglycan metabolism and Defective B3GAT3 causes JDSSDHD. GO annotations related to this gene include PDZ domain binding and cytoskeletal protein binding. An important paralog of this gene is SDC1.

UniProtKB/Swiss-Prot for SDC2 Gene

  • Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).

Gene Wiki entry for SDC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDC2 Gene

Genomics for SDC2 Gene

Regulatory Elements for SDC2 Gene

Enhancers for SDC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SDC2 on UCSC Golden Path with GeneCards custom track

Promoters for SDC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SDC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SDC2 Gene

96,493,351 bp from pter
96,611,809 bp from pter
118,459 bases
Plus strand

Genomic View for SDC2 Gene

Genes around SDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDC2 Gene

Proteins for SDC2 Gene

  • Protein details for SDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KQA3
    • Q6PIS6
    • Q9H6V1

    Protein attributes for SDC2 Gene

    201 amino acids
    Molecular mass:
    22160 Da
    Quaternary structure:
    • Interacts (via cytoplasmic domain) with SARM1 (By similarity). Forms a complex with SDCBP and PDCD6IP (PubMed:22660413).
    • Sequence=AAA52701.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SDC2 Gene

Proteomics data for SDC2 Gene at MOPED

Post-translational modifications for SDC2 Gene

  • O-glycosylated with core 1 or possibly core 8 glycans. Contains heparan sulfate.
  • Glycosylation at Ser 41, Ser 55, Ser 57, Ser 81, Thr 89, Thr 90, Thr 101, and Thr 107
  • Modification sites at PhosphoSitePlus

Other Protein References for SDC2 Gene

Antibody Products

  • R&D Systems Antibodies for SDC2 (Syndecan-2/CD362)

No data available for DME Specific Peptides for SDC2 Gene

Domains & Families for SDC2 Gene

Gene Families for SDC2 Gene

Suggested Antigen Peptide Sequences for SDC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the syndecan proteoglycan family.
  • Belongs to the syndecan proteoglycan family.
genes like me logo Genes that share domains with SDC2: view

Function for SDC2 Gene

Molecular function for SDC2 Gene

GENATLAS Biochemistry:
syndecan 2,heparan sulfate proteoglycan 1 (48kDa and 90kDa),cell surface-associated,lung,fibroblast,involved in a translocation t(X,8)(p22.13-q22.1) in a patient with autism and multiple exostoses
UniProtKB/Swiss-Prot Function:
Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).
genes like me logo Genes that share phenotypes with SDC2: view

Animal Models for SDC2 Gene

MGI Knock Outs for SDC2:
  • Sdc2 tm1b(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for SDC2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SDC2 Gene

Localization for SDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDC2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SDC2 Gene COMPARTMENTS Subcellular localization image for SDC2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
golgi apparatus 4
lysosome 4
vacuole 4
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with SDC2: view

Pathways & Interactions for SDC2 Gene

genes like me logo Genes that share pathways with SDC2: view

Gene Ontology (GO) - Biological Process for SDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0001666 response to hypoxia IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007411 axon guidance TAS --
GO:0007603 phototransduction, visible light TAS --
genes like me logo Genes that share ontologies with SDC2: view

No data available for SIGNOR curated interactions for SDC2 Gene

Drugs & Compounds for SDC2 Gene

(2) Drugs for SDC2 Gene - From: DrugBank and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sargramostim Approved, Investigational Pharma Target, agonist 0
Leukine Approved on November 24, 1995/ Approved November 1996 Pharma 0

(1) Additional Compounds for SDC2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
heparan sulfate
  • alpha-Idosane
  • Heparan N-sulfate
  • Heparan N-sulphate
  • Heparan sulfate
  • Heparan sulphate
genes like me logo Genes that share compounds with SDC2: view

Transcripts for SDC2 Gene

Unigene Clusters for SDC2 Gene

Syndecan 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SDC2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -

Relevant External Links for SDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SDC2 Gene

mRNA expression in normal human tissues for SDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SDC2 Gene

This gene is overexpressed in Pancreas (18.3), Cerebral cortex (14.0), and Adrenal (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDC2 Gene

SOURCE GeneReport for Unigene cluster for SDC2 Gene Hs.1501

genes like me logo Genes that share expression patterns with SDC2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SDC2 Gene

Orthologs for SDC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SDC2 35
  • 91.87 (n)
  • 91.54 (a)
SDC2 36
  • 92 (a)
(Canis familiaris)
Mammalia SDC2 35
  • 79.1 (n)
  • 83.24 (a)
SDC2 36
  • 51 (a)
(Mus musculus)
Mammalia Sdc2 35
  • 84.41 (n)
  • 84.08 (a)
Sdc2 16
Sdc2 36
  • 84 (a)
(Pan troglodytes)
Mammalia SDC2 35
  • 99.5 (n)
  • 99 (a)
SDC2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sdc2 35
  • 82.59 (n)
  • 81.09 (a)
(Monodelphis domestica)
Mammalia SDC2 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia SDC2 36
  • 83 (a)
(Gallus gallus)
Aves SDC2 35
  • 74.63 (n)
  • 72.64 (a)
(Anolis carolinensis)
Reptilia SDC2 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sdc2 35
  • 66.12 (n)
  • 60.33 (a)
Str.10701 35
African clawed frog
(Xenopus laevis)
Amphibia sdc2-A-prov 35
(Danio rerio)
Actinopterygii sdc2 35
  • 60.36 (n)
  • 61.08 (a)
sdc2 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sdc 36
  • 13 (a)
(Caenorhabditis elegans)
Secernentea sdn-1 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3537 36
  • 27 (a)
Species with no ortholog for SDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDC2 Gene

Gene Tree for SDC2 (if available)
Gene Tree for SDC2 (if available)

Paralogs for SDC2 Gene

Paralogs for SDC2 Gene

(2) SIMAP similar genes for SDC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SDC2: view

Variants for SDC2 Gene

Sequence variations from dbSNP and Humsavar for SDC2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs3816208 - 96,602,397(-) ATCAG(C/T)TCCTG reference, missense
rs1042381 - 96,602,433(+) CAACA(A/T)CTCGA reference, missense
rs2028086 -- 96,591,950(-) GTGAA(C/G)TGTGT intron-variant
rs2053647 -- 96,569,548(-) ATTTA(A/G)GTACC intron-variant
rs2118060 -- 96,562,354(-) TTTCA(G/T)CATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SDC2 Gene

Variant ID Type Subtype PubMed ID
nsv831404 CNV Gain 17160897
nsv519431 CNV Gain 19592680
nsv824691 CNV Gain 20364138
esv2737334 CNV Deletion 23290073
esv2737335 CNV Deletion 23290073
esv1008392 CNV Deletion 20482838
esv2667295 CNV Deletion 23128226
nsv824692 CNV Gain 20364138
nsv821376 CNV Deletion 20802225
esv27431 CNV Gain+Loss 19812545
nsv824693 CNV Loss 20364138
esv2661416 CNV Deletion 23128226
nsv819080 CNV Gain 19587683
dgv1298e199 CNV Deletion 23128226
esv2737336 CNV Deletion 23290073
esv7356 CNV Loss 19470904
dgv7836n71 CNV Loss 21882294
esv2537308 CNV Insertion 19546169
esv1386401 CNV Insertion 17803354
nsv396800 CNV Insertion 16902084
nsv6322 CNV Loss 18451855
nsv507475 CNV Insertion 20534489

Variation tolerance for SDC2 Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.79; 91.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDC2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDC2 Gene

Disorders for SDC2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SDC2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leri pleonosteosis
  • leri type pleonosteosis
trichorhinophalangeal syndrome, type i
  • trichorhinophalangeal syndrome, type iii
chronic cholangitis
trichorhinophalangeal syndrome, type ii
  • lennox-gastaut syndrome
rheumatic disease
  • rheumatic diseases
- elite association - COSMIC cancer census association via MalaCards
Search SDC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SDC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SDC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDC2 Gene

Publications for SDC2 Gene

  1. Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. (PMID: 22660413) Baietti M.F. … David G. (Nat. Cell Biol. 2012) 3 4 67
  2. Aberrant heparan sulfate proteoglycan localization, despite normal exostosin, in central chondrosarcoma. (PMID: 19179614) Schrage Y.M. … BovAce J.V. (Am. J. Pathol. 2009) 3 23
  3. Prognostic significance of altered expression of SDC2 and CYR61 in esophageal squamous cell carcinoma. (PMID: 19288017) Huang X. … Li E.M. (Oncol. Rep. 2009) 3 23
  4. Syndecan-2 is involved in the mitogenic activity and signaling of granulocyte-macrophage colony-stimulating factor in osteoblasts. (PMID: 10734053) Modrowski D. … Marie P.J. (J. Biol. Chem. 2000) 3 25
  5. Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene. (PMID: 9259269) Ishikawa-Brush Y. … Monaco A.P. (Hum. Mol. Genet. 1997) 3 23

Products for SDC2 Gene

Sources for SDC2 Gene