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Aliases for SDC2 Gene

Aliases for SDC2 Gene

  • Syndecan 2 2 3
  • Heparan Sulfate Proteoglycan 1, Cell Surface-Associated 2 3
  • Heparan Sulfate Proteoglycan Core Protein 3 4
  • Syndecan Proteoglycan 2 2 3
  • Fibroglycan 3 4
  • HSPG1 3 4
  • SYND2 3 4
  • HSPG 3 4
  • Cell Surface-Associated Heparan Sulfate Proteoglycan 1 3
  • CD362 Antigen 4
  • Fibroglycan) 6
  • Syndecan-2 3
  • CD362 3

External Ids for SDC2 Gene

Previous HGNC Symbols for SDC2 Gene

  • HSPG
  • HSPG1

Previous GeneCards Identifiers for SDC2 Gene

  • GC08P097579
  • GC08P097174
  • GC08P097462
  • GC08P097575
  • GC08P092711

Summaries for SDC2 Gene

Entrez Gene Summary for SDC2 Gene

  • The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]

GeneCards Summary for SDC2 Gene

SDC2 (Syndecan 2) is a Protein Coding gene. Diseases associated with SDC2 include hiv-1. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include PDZ domain binding and cytoskeletal protein binding. An important paralog of this gene is SDC4.

UniProtKB/Swiss-Prot for SDC2 Gene

  • Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).

Gene Wiki entry for SDC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDC2 Gene

Genomics for SDC2 Gene

Regulatory Elements for SDC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SDC2 Gene

Start:
96,493,351 bp from pter
End:
96,611,809 bp from pter
Size:
118,459 bases
Orientation:
Plus strand

Genomic View for SDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDC2 Gene

Proteins for SDC2 Gene

  • Protein details for SDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34741-SDC2_HUMAN
    Recommended name:
    Syndecan-2
    Protein Accession:
    P34741
    Secondary Accessions:
    • B3KQA3
    • Q6PIS6
    • Q9H6V1

    Protein attributes for SDC2 Gene

    Size:
    201 amino acids
    Molecular mass:
    22160 Da
    Quaternary structure:
    • Interacts (via cytoplasmic domain) with SARM1.
    SequenceCaution:
    • Sequence=AAA52701.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SDC2 Gene

Proteomics data for SDC2 Gene at MOPED

Post-translational modifications for SDC2 Gene

  • O-glycosylated with core 1 or possibly core 8 glycans. Contains heparan sulfate.
  • Glycosylation at Ser41, Ser55, Ser57, Thr80, Ser81, Thr88, Thr89, Thr90, Thr101, and Thr107
  • Modification sites at PhosphoSitePlus

Other Protein References for SDC2 Gene

Antibody Products

No data available for DME Specific Peptides for SDC2 Gene

Domains for SDC2 Gene

Gene Families for SDC2 Gene

HGNC:
  • CD :CD molecules
  • SDC :Proteoglycans / Cell Surface : Syndecans

Protein Domains for SDC2 Gene

Suggested Antigen Peptide Sequences for SDC2 Gene

Graphical View of Domain Structure for InterPro Entry

P34741

UniProtKB/Swiss-Prot:

SDC2_HUMAN :
  • P34741
Family:
  • Belongs to the syndecan proteoglycan family.
genes like me logo Genes that share domains with SDC2: view

Function for SDC2 Gene

Molecular function for SDC2 Gene

GENATLAS Biochemistry: syndecan 2,heparan sulfate proteoglycan 1 (48kDa and 90kDa),cell surface-associated,lung,fibroblast,involved in a translocation t(X,8)(p22.13-q22.1) in a patient with autism and multiple exostoses
UniProtKB/Swiss-Prot Function: Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for SDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11356864
GO:0008092 cytoskeletal protein binding --
GO:0030165 PDZ domain binding IPI 18256285
genes like me logo Genes that share ontologies with SDC2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SDC2 Gene

Localization for SDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDC2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDC2 Gene COMPARTMENTS Subcellular localization image for SDC2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
lysosome 4
vacuole 4
extracellular 3
cytoskeleton 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SDC2: view

Pathways for SDC2 Gene

genes like me logo Genes that share pathways with SDC2: view

Gene Ontology (GO) - Biological Process for SDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0001666 response to hypoxia IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0006027 glycosaminoglycan catabolic process TAS --
genes like me logo Genes that share ontologies with SDC2: view

Compounds for SDC2 Gene

(1) HMDB Compounds for SDC2 Gene

Compound Synonyms Cas Number PubMed IDs
Heparan sulfate
  • HHS 5
9050-30-0

(1) Drugbank Compounds for SDC2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Sargramostim
  • Colony-stimulating factor
83869-56-1 target agonist

(1) Novoseek inferred chemical compound relationships for SDC2 Gene

Compound -log(P) Hits PubMed IDs
heparan sulfate 74.8 4
genes like me logo Genes that share compounds with SDC2: view

Transcripts for SDC2 Gene

Unigene Clusters for SDC2 Gene

Syndecan 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDC2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDC2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -
SP3:

Relevant External Links for SDC2 Gene

GeneLoc Exon Structure for
SDC2
ECgene alternative splicing isoforms for
SDC2

Expression for SDC2 Gene

mRNA expression in normal human tissues for SDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDC2 Gene

SOURCE GeneReport for Unigene cluster for SDC2 Gene Hs.1501

genes like me logo Genes that share expressions with SDC2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SDC2 Gene

Orthologs for SDC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDC2 35
  • 99.5 (n)
  • 99 (a)
SDC2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SDC2 35
  • 91.87 (n)
  • 91.54 (a)
SDC2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SDC2 35
  • 79.1 (n)
  • 83.24 (a)
SDC2 36
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdc2 35
  • 84.41 (n)
  • 84.08 (a)
Sdc2 16
Sdc2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SDC2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDC2 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sdc2 35
  • 82.59 (n)
  • 81.09 (a)
chicken
(Gallus gallus)
Aves SDC2 35
  • 74.63 (n)
  • 72.64 (a)
lizard
(Anolis carolinensis)
Reptilia SDC2 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sdc2-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sdc2 35
  • 66.12 (n)
  • 60.33 (a)
Str.10701 35
zebrafish
(Danio rerio)
Actinopterygii sdc2 35
  • 60.36 (n)
  • 61.08 (a)
sdc2 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sdc 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sdn-1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3537 36
  • 27 (a)
OneToMany
Species with no ortholog for SDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDC2 Gene

ENSEMBL:
Gene Tree for SDC2 (if available)
TreeFam:
Gene Tree for SDC2 (if available)

Paralogs for SDC2 Gene

Paralogs for SDC2 Gene

Selected SIMAP similar genes for SDC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SDC2: view

Variants for SDC2 Gene

Sequence variations from dbSNP and Humsavar for SDC2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs7040 -- 96,608,379(+) GACTC(A/T)GAAAG reference, synonymous-codon
rs724235 -- 96,570,759(+) TTTAA(A/G)TGTTC intron-variant
rs724236 -- 96,570,837(+) acact(A/T)ttatt intron-variant
rs874643 -- 96,529,915(+) TTCCT(C/T)AGGCA intron-variant
rs874644 -- 96,530,181(+) TGATT(A/G)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SDC2 Gene

Variant ID Type Subtype PubMed ID
nsv831404 CNV Gain 17160897
nsv519431 CNV Gain 19592680
nsv824691 CNV Gain 20364138
esv2737334 CNV Deletion 23290073
esv2737335 CNV Deletion 23290073
esv1008392 CNV Deletion 20482838
esv2667295 CNV Deletion 23128226
nsv824692 CNV Gain 20364138
nsv821376 CNV Deletion 20802225
esv27431 CNV Gain+Loss 19812545
nsv824693 CNV Loss 20364138
esv2661416 CNV Deletion 23128226
nsv819080 CNV Gain 19587683
dgv1298e199 CNV Deletion 23128226
esv2737336 CNV Deletion 23290073
esv7356 CNV Loss 19470904
dgv7836n71 CNV Loss 21882294
esv2537308 CNV Insertion 19546169
esv1386401 CNV Insertion 17803354
nsv396800 CNV Insertion 16902084
nsv6322 CNV Loss 18451855
nsv507475 CNV Insertion 20534489

Relevant External Links for SDC2 Gene

HapMap Linkage Disequilibrium report
SDC2
Human Gene Mutation Database (HGMD)
SDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDC2 Gene

Disorders for SDC2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SDC2 Gene including...

Search for SDC2 Gene in MalaCards »

(1) Novoseek inferred disease relationships for SDC2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for SDC2

Genetic Association Database (GAD)
SDC2
Human Genome Epidemiology (HuGE) Navigator
SDC2
genes like me logo Genes that share disorders with SDC2: view

No data available for UniProtKB/Swiss-Prot for SDC2 Gene

Publications for SDC2 Gene

  1. Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene. (PMID: 9259269) Ishikawa-Brush Y. … Monaco A.P. (Hum. Mol. Genet. 1997) 3 23
  2. Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development. (PMID: 8187643) David G. … Van den Berghe H. (Development 1993) 2 3
  3. Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts. (PMID: 2523388) Marynen P. … David G. (J. Biol. Chem. 1989) 3 4
  4. The heparan sulfate proteoglycan gene polymorphism: association with type 2 diabetic nephropathy in Chinese. (PMID: 12708751) Liu L. … Li J. (Mol. Cell. Biochem. 2003) 3 48
  5. Co-inheritance of specific genotypes of HSPG and ApoE gene increases risk of type 2 diabetic nephropathy. (PMID: 14674716) Liu L. … Li J. (Mol. Cell. Biochem. 2003) 3 48

Products for SDC2 Gene

Sources for SDC2 Gene

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