Aliases for SDC1 Gene
External Ids for SDC1 Gene
Previous Symbols for SDC1 Gene
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for SDC1 Gene
SDC1 (Syndecan 1) is a Protein Coding gene. Diseases associated with SDC1 include hiv-1 and intestinal disease. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include protein C-terminus binding and glycoprotein binding. An important paralog of this gene is SDC4.
UniProtKB/Swiss-Prot for SDC1 Gene
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix