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Aliases for SDC1 Gene

Aliases for SDC1 Gene

  • Syndecan 1 2 3 5
  • Syndecan Proteoglycan 1 2 3
  • CD138 Antigen 3 4
  • SYND1 3 4
  • SDC 3 4
  • Heparan Sulfate Proteoglycan Fibroblast Growth Factor Receptor 3
  • Syndecan 3
  • CD138 3

External Ids for SDC1 Gene

Previous HGNC Symbols for SDC1 Gene

  • SDC

Previous GeneCards Identifiers for SDC1 Gene

  • GC02M020292
  • GC02M020469
  • GC02M020368
  • GC02M020385
  • GC02M020322
  • GC02M020264
  • GC02M020400
  • GC02M020158

Summaries for SDC1 Gene

Entrez Gene Summary for SDC1 Gene

  • The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SDC1 Gene

SDC1 (Syndecan 1) is a Protein Coding gene. Diseases associated with SDC1 include Ameloblastic Carcinoma and Multiple Myeloma. Among its related pathways are Glycosaminoglycan metabolism and Defective B3GAT3 causes JDSSDHD. GO annotations related to this gene include protein C-terminus binding and glycoprotein binding. An important paralog of this gene is SDC4.

UniProtKB/Swiss-Prot for SDC1 Gene

  • Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).

Gene Wiki entry for SDC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDC1 Gene

Genomics for SDC1 Gene

Regulatory Elements for SDC1 Gene

Enhancers for SDC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SDC1 on UCSC Golden Path with GeneCards custom track

Promoters for SDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SDC1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SDC1 gene promoter:

Genomic Location for SDC1 Gene

20,200,797 bp from pter
20,225,433 bp from pter
24,637 bases
Minus strand

Genomic View for SDC1 Gene

Genes around SDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDC1 Gene

Proteins for SDC1 Gene

  • Protein details for SDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D6W523
    • Q53QV0
    • Q546D3
    • Q96HB7

    Protein attributes for SDC1 Gene

    310 amino acids
    Molecular mass:
    32462 Da
    Quaternary structure:
    • Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain).

    Three dimensional structures from OCA and Proteopedia for SDC1 Gene

neXtProt entry for SDC1 Gene

Proteomics data for SDC1 Gene at MOPED

Post-translational modifications for SDC1 Gene

  • Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
  • Glycosylation at Ser 37, Asn 43, Ser 45, Ser 47, Thr 61, Ser 77, Thr 122, Thr 188, Ser 206, Ser 216, and Thr 240
  • Modification sites at PhosphoSitePlus

Other Protein References for SDC1 Gene

Antibody Products

  • R&D Systems Antibodies for SDC1 (Syndecan-1/CD138)
  • Cell Signaling Technology (CST) Antibodies for SDC1 (syndecan-1)

No data available for DME Specific Peptides for SDC1 Gene

Domains & Families for SDC1 Gene

Gene Families for SDC1 Gene

Suggested Antigen Peptide Sequences for SDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the syndecan proteoglycan family.
  • Belongs to the syndecan proteoglycan family.
genes like me logo Genes that share domains with SDC1: view

Function for SDC1 Gene

Molecular function for SDC1 Gene

GENATLAS Biochemistry:
syndecan,integral membrane heparan sulfate proteoglycan,matrix receptor,expressed in distinct stages of differentiation of normal lymphoid cells (pre-B) and in B chronic lymphoblastic leukemia (BCLL) in plamocytoid lymphomas and myelomas,underexpressed in squamous cell carcinoma of the head and neck
UniProtKB/Swiss-Prot Function:
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
genes like me logo Genes that share phenotypes with SDC1: view

Animal Models for SDC1 Gene

MGI Knock Outs for SDC1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SDC1 Gene

Localization for SDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDC1 Gene

Membrane; Single-pass type I membrane protein. Secreted. Secreted, exosome. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000269 PubMed:9169435}.

Subcellular locations from

Jensen Localization Image for SDC1 Gene COMPARTMENTS Subcellular localization image for SDC1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
lysosome 5
plasma membrane 5
vacuole 5
cytosol 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with SDC1: view

Pathways & Interactions for SDC1 Gene

genes like me logo Genes that share pathways with SDC1: view

Gene Ontology (GO) - Biological Process for SDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006954 inflammatory response IEA --
GO:0007603 phototransduction, visible light TAS --
GO:0009636 response to toxic substance IEA --
genes like me logo Genes that share ontologies with SDC1: view

No data available for SIGNOR curated interactions for SDC1 Gene

Drugs & Compounds for SDC1 Gene

(1) Additional Compounds for SDC1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
heparan sulfate
  • alpha-Idosane
  • Heparan N-sulfate
  • Heparan N-sulphate
  • Heparan sulfate
  • Heparan sulphate
genes like me logo Genes that share compounds with SDC1: view

Transcripts for SDC1 Gene

Unigene Clusters for SDC1 Gene

Syndecan 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SDC1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - - -
SP6: - -

Relevant External Links for SDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SDC1 Gene

mRNA expression in normal human tissues for SDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDC1 Gene

This gene is overexpressed in Liver (x8.6), Esophagus - Mucosa (x8.2), Skin - Not Sun Exposed (Suprapubic) (x7.8), and Skin - Sun Exposed (Lower leg) (x7.1).

Protein differential expression in normal tissues from HIPED for SDC1 Gene

This gene is overexpressed in Hair follicle (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDC1 Gene

SOURCE GeneReport for Unigene cluster for SDC1 Gene Hs.224607

genes like me logo Genes that share expression patterns with SDC1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SDC1 Gene

Orthologs for SDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SDC1 35
  • 80.95 (n)
  • 74.68 (a)
SDC1 36
  • 74 (a)
(Canis familiaris)
Mammalia SDC1 35
  • 83.33 (n)
  • 80.65 (a)
SDC1 36
  • 81 (a)
(Mus musculus)
Mammalia Sdc1 35
  • 80.15 (n)
  • 77.02 (a)
Sdc1 16
Sdc1 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Sdc1 35
  • 80.75 (n)
  • 77.74 (a)
(Ornithorhynchus anatinus)
Mammalia SDC1 36
  • 40 (a)
(Gallus gallus)
Aves SDC1 35
  • 51.11 (n)
  • 46.67 (a)
SDC1 36
  • 33 (a)
(Anolis carolinensis)
Reptilia SDC1 36
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sdc 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea sdn-1 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3537 36
  • 27 (a)
Species with no ortholog for SDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SDC1 Gene

Gene Tree for SDC1 (if available)
Gene Tree for SDC1 (if available)

Paralogs for SDC1 Gene

Paralogs for SDC1 Gene Pseudogenes for SDC1 Gene

genes like me logo Genes that share paralogs with SDC1: view

Variants for SDC1 Gene

Sequence variations from dbSNP and Humsavar for SDC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2230922 - 20,204,213(-) TCCCA(C/T)GTCTC reference, missense
rs10205485 - 20,204,033(+) AGGCC(A/T)GATGA reference, missense
rs1574263 -- 20,209,349(-) TGCAC(A/G)GGGAG intron-variant, upstream-variant-2KB
rs1804487 -- 20,201,986(-) GGCCC(C/T)GTTTC utr-variant-3-prime
rs2881927 -- 20,225,784(+) AGCGT(C/T)TTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SDC1 Gene

Variant ID Type Subtype PubMed ID
esv29979 CNV Loss 17803354
nsv819169 CNV Gain 19587683
esv29269 CNV Loss 19812545

Variation tolerance for SDC1 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SDC1 Gene

Disorders for SDC1 Gene

MalaCards: The human disease database

(21) MalaCards diseases for SDC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ameloblastic carcinoma
multiple myeloma
  • plasma cell neoplasm
diffuse large b-cell lymphoma
  • large b cell diffuse lymphoma
intestinal disease
  • intestinal diseases
extrahepatic bile duct adenocarcinoma
  • adenocarcinoma of extrahepatic bile duct
- elite association - COSMIC cancer census association via MalaCards
Search SDC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SDC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SDC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDC1 Gene

Publications for SDC1 Gene

  1. Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. (PMID: 22660413) Baietti M.F. … David G. (Nat. Cell Biol. 2012) 3 4 67
  2. Bone marrow stromal cell interaction reduces syndecan-1 expression and induces kinomic changes in myeloma cells. (PMID: 20307537) Fuhler G.M. … Bos N.A. (Exp. Cell Res. 2010) 3 23
  3. Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. (PMID: 19255147) Beauvais D.M. … Rapraeger A.C. (J. Exp. Med. 2009) 3 23
  4. Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation. (PMID: 19010933) Su G. … Friedl A. (Cancer Res. 2008) 3 23
  5. Evaluation of the association with cervical cancer of polymorphisms in syndecan-1, a heparan sulfate proteoglycan involved with viral cell entry. (PMID: 18006945) Yu K.J. … Hildesheim A. (Cancer Epidemiol. Biomarkers Prev. 2007) 3 23

Products for SDC1 Gene

Sources for SDC1 Gene