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Aliases for SDAD1 Gene

Aliases for SDAD1 Gene

  • SDA1 Domain Containing 1 2 3 5
  • SDA1 Domain-Containing Protein 1 4
  • Nucleolar Protein 130 4
  • NUC130 4
  • HSDA 4

External Ids for SDAD1 Gene

Previous GeneCards Identifiers for SDAD1 Gene

  • GC04M077330
  • GC04M077228
  • GC04M077090
  • GC04M076871
  • GC04M072623

Summaries for SDAD1 Gene

GeneCards Summary for SDAD1 Gene

SDAD1 (SDA1 Domain Containing 1) is a Protein Coding gene. Diseases associated with SDAD1 include allergic rhinitis and rhinitis. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for SDAD1 Gene

  • Required for 60S pre-ribosomal subunits export to the cytoplasm.

Gene Wiki entry for SDAD1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDAD1 Gene

Genomics for SDAD1 Gene

Regulatory Elements for SDAD1 Gene

Promoters for SDAD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SDAD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SDAD1 Gene

Chromosome:
4
Start:
75,940,950 bp from pter
End:
75,990,962 bp from pter
Size:
50,013 bases
Orientation:
Minus strand

Genomic View for SDAD1 Gene

Genes around SDAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDAD1 Gene

Proteins for SDAD1 Gene

  • Protein details for SDAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVU7-SDA1_HUMAN
    Recommended name:
    Protein SDA1 homolog
    Protein Accession:
    Q9NVU7
    Secondary Accessions:
    • Q32Q11
    • Q68D52
    • Q7Z5U4
    • Q9H831
    • Q9H9P6

    Protein attributes for SDAD1 Gene

    Size:
    687 amino acids
    Molecular mass:
    79871 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • DAZL and PUM2 bind its 3-UTR mRNA, suggesting that these proteins may regulate its translation.
    SequenceCaution:
    • Sequence=AAI07896.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91648.1; Type=Frameshift; Positions=53; Evidence={ECO:0000305}; Sequence=BAB14177.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SDAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDAD1 Gene

Proteomics data for SDAD1 Gene at MOPED

Post-translational modifications for SDAD1 Gene

  • Ubiquitination at Lys 21
  • Modification sites at PhosphoSitePlus

Other Protein References for SDAD1 Gene

No data available for DME Specific Peptides for SDAD1 Gene

Domains & Families for SDAD1 Gene

Protein Domains for SDAD1 Gene

Suggested Antigen Peptide Sequences for SDAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVU7

UniProtKB/Swiss-Prot:

SDA1_HUMAN :
  • Belongs to the SDA1 family.
Family:
  • Belongs to the SDA1 family.
genes like me logo Genes that share domains with SDAD1: view

No data available for Gene Families for SDAD1 Gene

Function for SDAD1 Gene

Molecular function for SDAD1 Gene

UniProtKB/Swiss-Prot Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
genes like me logo Genes that share phenotypes with SDAD1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDAD1 Gene

Localization for SDAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDAD1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDAD1 Gene COMPARTMENTS Subcellular localization image for SDAD1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for SDAD1 Gene

Pathways & Interactions for SDAD1 Gene

SuperPathways for SDAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0042273 ribosomal large subunit biogenesis IEA,ISS --
genes like me logo Genes that share ontologies with SDAD1: view

No data available for Pathways by source and SIGNOR curated interactions for SDAD1 Gene

Drugs & Compounds for SDAD1 Gene

No Compound Related Data Available

Transcripts for SDAD1 Gene

Unigene Clusters for SDAD1 Gene

SDA1 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SDAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for SDAD1 Gene

GeneLoc Exon Structure for
SDAD1
ECgene alternative splicing isoforms for
SDAD1

Expression for SDAD1 Gene

mRNA expression in normal human tissues for SDAD1 Gene

Protein differential expression in normal tissues from HIPED for SDAD1 Gene

This gene is overexpressed in Lung (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDAD1 Gene



SOURCE GeneReport for Unigene cluster for SDAD1 Gene Hs.632604

mRNA Expression by UniProt/SwissProt for SDAD1 Gene

Q9NVU7-SDA1_HUMAN
Tissue specificity: Highly expressed in testis, kidney, spleen, brain and fetal tissues. Also expressed at lower level in heart, lung, liver, small intestine, ovary, uterus, mammary gland and placenta.
genes like me logo Genes that share expression patterns with SDAD1: view

Protein tissue co-expression partners for SDAD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SDAD1 Gene

Orthologs for SDAD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDAD1 35
  • 99.71 (n)
  • 100 (a)
SDAD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SDAD1 36
  • 95 (a)
OneToOne
SDAD1 35
  • 91.12 (n)
  • 94.32 (a)
dog
(Canis familiaris)
Mammalia SDAD1 35
  • 89.59 (n)
  • 91.35 (a)
SDAD1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdad1 36
  • 94 (a)
OneToOne
Sdad1 16
Sdad1 35
  • 87.82 (n)
  • 94.03 (a)
oppossum
(Monodelphis domestica)
Mammalia SDAD1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDAD1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sdad1 35
  • 86.78 (n)
  • 94.02 (a)
chicken
(Gallus gallus)
Aves SDAD1 36
  • 83 (a)
OneToOne
SDAD1 35
  • 77.7 (n)
  • 83.67 (a)
lizard
(Anolis carolinensis)
Reptilia SDAD1 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398506 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sdad1 35
  • 74.31 (n)
  • 81.9 (a)
Str.17243 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1827 35
zebrafish
(Danio rerio)
Actinopterygii sdad1 36
  • 78 (a)
OneToOne
flj10498 35
sdad1 35
  • 73.24 (n)
  • 78.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mys45A 36
  • 50 (a)
OneToOne
Mys45A 35
  • 57.21 (n)
  • 53.13 (a)
worm
(Caenorhabditis elegans)
Secernentea pro-3 35
  • 51.27 (n)
  • 41.85 (a)
pro-3 36
  • 34 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL212W 35
  • 46.48 (n)
  • 38.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SDA1 36
  • 34 (a)
OneToOne
SDA1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4149 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6735 36
  • 55 (a)
OneToOne
Species with no ortholog for SDAD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDAD1 Gene

ENSEMBL:
Gene Tree for SDAD1 (if available)
TreeFam:
Gene Tree for SDAD1 (if available)

Paralogs for SDAD1 Gene

genes like me logo Genes that share paralogs with SDAD1: view

No data available for Paralogs for SDAD1 Gene

Variants for SDAD1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SDAD1 Gene

Q9NVU7-SDA1_HUMAN
Variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis (SAR). SAR is a common allergic disorder characterized by episodes of sneezing, rhinorrhea, and swelling of the nasal mucosa.

Sequence variations from dbSNP and Humsavar for SDAD1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs15481 - 75,971,398(-) GTTCC(A/C)AAAAC reference, missense
rs34627298 - 75,960,080(+) TTTCA(G/T)CATTC reference, missense
rs2242471 - 75,957,563(+) TCTGG(C/G)ATTTC reference, missense
rs17001276 - 75,956,013(+) CCGGA(C/T)ATTCT reference, missense
rs2273 -- 75,968,235(+) TCCTA(C/T)ACTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SDAD1 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855

Variation tolerance for SDAD1 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.29; 92.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDAD1 Gene

HapMap Linkage Disequilibrium report
SDAD1

Disorders for SDAD1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SDAD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
allergic rhinitis
  • atopic rhinitis
rhinitis
  • runny nose
- elite association - COSMIC cancer census association via MalaCards
Search SDAD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SDAD1

Genetic Association Database (GAD)
SDAD1
Human Genome Epidemiology (HuGE) Navigator
SDAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDAD1
genes like me logo Genes that share disorders with SDAD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDAD1 Gene

Publications for SDAD1 Gene

  1. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin A.I. … Ukraintseva S.V. (Aging (Albany NY) 2010) 3 48 67
  2. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for SDAD1 Gene

Sources for SDAD1 Gene

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