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Aliases for SDAD1 Gene

Aliases for SDAD1 Gene

  • SDA1 Domain Containing 1 2 3 5
  • SDA1 Domain-Containing Protein 1 4
  • Nucleolar Protein 130 4
  • NUC130 4
  • HSDA 4

External Ids for SDAD1 Gene

Previous GeneCards Identifiers for SDAD1 Gene

  • GC04M077330
  • GC04M077228
  • GC04M077090
  • GC04M076871
  • GC04M072623

Summaries for SDAD1 Gene

GeneCards Summary for SDAD1 Gene

SDAD1 (SDA1 Domain Containing 1) is a Protein Coding gene. Diseases associated with SDAD1 include Rhinitis and Allergic Rhinitis. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for SDAD1 Gene

  • Required for 60S pre-ribosomal subunits export to the cytoplasm.

Gene Wiki entry for SDAD1 Gene

Additional gene information for SDAD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDAD1 Gene

Genomics for SDAD1 Gene

Regulatory Elements for SDAD1 Gene

Enhancers for SDAD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H076947 1.6 FANTOM5 ENCODE dbSUPER 16.3 -959.3 -959289 5.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 SP3 NUP54 SDAD1 SOWAHB RPL7P17 CNOT6L SEPT11 MRPL1 GC04P076953
GH04H076205 1.7 FANTOM5 ENCODE dbSUPER 14.7 -219.8 -219833 10.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 NUP54 FAM47E THAP6 SDAD1 ART3 NAAA SCARB2 G3BP2 STBD1 CXCL10
GH04H076801 1.2 Ensembl ENCODE 16.2 -812.1 -812058 3.5 PKNOX1 ATF1 INSM2 KLF17 TCF12 GLIS2 ZNF366 FOS ATF7 RUNX3 SDAD1 NUP54 LOC105377289 PIR31989
GH04H076089 1.6 FANTOM5 Ensembl ENCODE 11.1 -99.4 -99370 2.1 PKNOX1 ATF1 ARNT BRCA1 TCF12 ZNF766 GATA2 FOS ATF7 ZNF592 NUP54 CXCL10 CXCL9 SDAD1 ART3 NAAA CXCL11 GC04P076101
GH04H076233 1.4 Ensembl ENCODE dbSUPER 10.4 -245.0 -244957 5.5 ATF1 ZBTB40 CHAMP1 TCF12 ZNF766 ELK1 EGR1 FOS RCOR1 CREM FAM47E NUP54 SCARB2 THAP6 SDAD1 ENSG00000251185 STBD1 LOC105377286
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SDAD1 on UCSC Golden Path with GeneCards custom track

Promoters for SDAD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000169435 362 1601 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 ZNF143

Genomic Locations for SDAD1 Gene

Genomic Locations for SDAD1 Gene
chr4:75,940,950-75,990,962
(GRCh38/hg38)
Size:
50,013 bases
Orientation:
Minus strand
chr4:76,862,103-76,912,115
(GRCh37/hg19)

Genomic View for SDAD1 Gene

Genes around SDAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDAD1 Gene

Proteins for SDAD1 Gene

  • Protein details for SDAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVU7-SDA1_HUMAN
    Recommended name:
    Protein SDA1 homolog
    Protein Accession:
    Q9NVU7
    Secondary Accessions:
    • Q32Q11
    • Q68D52
    • Q7Z5U4
    • Q9H831
    • Q9H9P6

    Protein attributes for SDAD1 Gene

    Size:
    687 amino acids
    Molecular mass:
    79871 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • DAZL and PUM2 bind its 3-UTR mRNA, suggesting that these proteins may regulate its translation.
    SequenceCaution:
    • Sequence=AAI07896.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91648.1; Type=Frameshift; Positions=53; Evidence={ECO:0000305}; Sequence=BAB14177.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SDAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDAD1 Gene

Post-translational modifications for SDAD1 Gene

  • Ubiquitination at Lys21
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SDAD1 Gene

Domains & Families for SDAD1 Gene

Gene Families for SDAD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SDAD1 Gene

Suggested Antigen Peptide Sequences for SDAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVU7

UniProtKB/Swiss-Prot:

SDA1_HUMAN :
  • Belongs to the SDA1 family.
Family:
  • Belongs to the SDA1 family.
genes like me logo Genes that share domains with SDAD1: view

Function for SDAD1 Gene

Molecular function for SDAD1 Gene

UniProtKB/Swiss-Prot Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.

Phenotypes From GWAS Catalog for SDAD1 Gene

Gene Ontology (GO) - Molecular Function for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SDAD1: view
genes like me logo Genes that share phenotypes with SDAD1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDAD1 Gene

Localization for SDAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDAD1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDAD1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA 11790298
genes like me logo Genes that share ontologies with SDAD1: view

Pathways & Interactions for SDAD1 Gene

SuperPathways for SDAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IEA --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0030036 actin cytoskeleton organization IEA,IBA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with SDAD1: view

No data available for Pathways by source and SIGNOR curated interactions for SDAD1 Gene

Drugs & Compounds for SDAD1 Gene

No Compound Related Data Available

Transcripts for SDAD1 Gene

Unigene Clusters for SDAD1 Gene

SDA1 domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for SDAD1 Gene

GeneLoc Exon Structure for
SDAD1
ECgene alternative splicing isoforms for
SDAD1

Expression for SDAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDAD1 Gene

Protein differential expression in normal tissues from HIPED for SDAD1 Gene

This gene is overexpressed in Lung (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SDAD1 Gene



Protein tissue co-expression partners for SDAD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SDAD1 Gene:

SDAD1

SOURCE GeneReport for Unigene cluster for SDAD1 Gene:

Hs.632604

mRNA Expression by UniProt/SwissProt for SDAD1 Gene:

Q9NVU7-SDA1_HUMAN
Tissue specificity: Highly expressed in testis, kidney, spleen, brain and fetal tissues. Also expressed at lower level in heart, lung, liver, small intestine, ovary, uterus, mammary gland and placenta.

Evidence on tissue expression from TISSUES for SDAD1 Gene

  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with SDAD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDAD1 Gene

Orthologs for SDAD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDAD1 33 34
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia SDAD1 33 34
  • 91.12 (n)
dog
(Canis familiaris)
Mammalia SDAD1 33 34
  • 89.59 (n)
oppossum
(Monodelphis domestica)
Mammalia SDAD1 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdad1 33 16 34
  • 87.82 (n)
rat
(Rattus norvegicus)
Mammalia Sdad1 33
  • 86.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SDAD1 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDAD1 33 34
  • 77.7 (n)
lizard
(Anolis carolinensis)
Reptilia SDAD1 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sdad1 33
  • 74.31 (n)
Str.17243 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398506 33
zebrafish
(Danio rerio)
Actinopterygii sdad1 33 34
  • 73.24 (n)
flj10498 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1827 33
fruit fly
(Drosophila melanogaster)
Insecta Mys45A 33 34
  • 57.21 (n)
worm
(Caenorhabditis elegans)
Secernentea pro-3 33 34
  • 51.27 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL212W 33
  • 46.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SDA1 34 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6735 34
  • 55 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4149 33
Species where no ortholog for SDAD1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDAD1 Gene

ENSEMBL:
Gene Tree for SDAD1 (if available)
TreeFam:
Gene Tree for SDAD1 (if available)

Paralogs for SDAD1 Gene

genes like me logo Genes that share paralogs with SDAD1: view

No data available for Paralogs for SDAD1 Gene

Variants for SDAD1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SDAD1 Gene

SDA1_HUMAN-Q9NVU7
Variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis (SAR). SAR is a common allergic disorder characterized by episodes of sneezing, rhinorrhea, and swelling of the nasal mucosa.

Sequence variations from dbSNP and Humsavar for SDAD1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000124122 -- 75,949,462(+) TAATC(A/C)CAGCA downstream-variant-500B
rs1000170419 -- 75,950,178(+) AAAGA(A/G)CTAAA utr-variant-3-prime
rs1000225081 -- 75,949,871(+) CGCCT(A/G)TGGAA downstream-variant-500B
rs1000242925 -- 75,991,061(+) TCTGT(A/G/T)GTGTA intron-variant, upstream-variant-2KB
rs1000250167 -- 75,960,714(+) TGTGC(A/T)ATAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SDAD1 Gene

Variant ID Type Subtype PubMed ID
nsv967764 CNV duplication 23825009
nsv7363 OTHER inversion 18451855
esv3449791 CNV insertion 20981092

Variation tolerance for SDAD1 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.29; 92.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDAD1

Disorders for SDAD1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SDAD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rhinitis
  • runny nose
allergic rhinitis
  • atopic rhinitis
- elite association - COSMIC cancer census association via MalaCards
Search SDAD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SDAD1

Genetic Association Database (GAD)
SDAD1
Human Genome Epidemiology (HuGE) Navigator
SDAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDAD1
genes like me logo Genes that share disorders with SDAD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDAD1 Gene

Publications for SDAD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin AI … Ukraintseva SV (Aging 2010) 3 45 60
  3. Association of a haplotype block spanning SDAD1 gene and CXC chemokine genes with allergic rhinitis. (PMID: 15753903) Zhang J … Arinami T (The Journal of allergy and clinical immunology 2005) 4 22 60
  4. Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind. (PMID: 15607425) Fox M … Reijo Pera RA (Genomics 2005) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for SDAD1 Gene

Sources for SDAD1 Gene

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