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Aliases for SDAD1 Gene

Aliases for SDAD1 Gene

  • SDA1 Domain Containing 1 2 3
  • SDA1 Domain-Containing Protein 1 4
  • Nucleolar Protein 130 4
  • NUC130 4
  • HSDA 4

External Ids for SDAD1 Gene

Previous GeneCards Identifiers for SDAD1 Gene

  • GC04M077330
  • GC04M077228
  • GC04M077090
  • GC04M076871
  • GC04M072623

Summaries for SDAD1 Gene

GeneCards Summary for SDAD1 Gene

SDAD1 (SDA1 Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SDAD1 Gene

  • Required for 60S pre-ribosomal subunits export to the cytoplasm.

Gene Wiki entry for SDAD1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDAD1 Gene

Genomics for SDAD1 Gene

Regulatory Elements for SDAD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SDAD1 Gene

Start:
75,940,950 bp from pter
End:
75,990,962 bp from pter
Size:
50,013 bases
Orientation:
Minus strand

Genomic View for SDAD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SDAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDAD1 Gene

Proteins for SDAD1 Gene

  • Protein details for SDAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVU7-SDA1_HUMAN
    Recommended name:
    Protein SDA1 homolog
    Protein Accession:
    Q9NVU7
    Secondary Accessions:
    • Q32Q11
    • Q68D52
    • Q7Z5U4
    • Q9H831
    • Q9H9P6

    Protein attributes for SDAD1 Gene

    Size:
    687 amino acids
    Molecular mass:
    79871 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • DAZL and PUM2 bind its 3-UTR mRNA, suggesting that these proteins may regulate its translation
    SequenceCaution:
    • Sequence=AAI07896.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91648.1; Type=Frameshift; Positions=53; Evidence={ECO:0000305}; Sequence=BAB14177.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SDAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDAD1 Gene

Proteomics data for SDAD1 Gene at MOPED

Post-translational modifications for SDAD1 Gene

  • Ubiquitination at Lys21
  • Modification sites at PhosphoSitePlus

Other Protein References for SDAD1 Gene

No data available for DME Specific Peptides for SDAD1 Gene

Domains for SDAD1 Gene

Protein Domains for SDAD1 Gene

Suggested Antigen Peptide Sequences for SDAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVU7

UniProtKB/Swiss-Prot:

SDA1_HUMAN :
  • Q9NVU7
Family:
  • Belongs to the SDA1 family.
genes like me logo Genes that share domains with SDAD1: view

No data available for Gene Families for SDAD1 Gene

Function for SDAD1 Gene

Molecular function for SDAD1 Gene

UniProtKB/Swiss-Prot Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.

Gene Ontology (GO) - Molecular Function for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005488 binding --
genes like me logo Genes that share ontologies with SDAD1: view

Phenotypes for SDAD1 Gene

genes like me logo Genes that share phenotypes with SDAD1: view

Animal Model Products

miRNA for SDAD1 Gene

miRTarBase miRNAs that target SDAD1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDAD1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SDAD1 Gene

Localization for SDAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDAD1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDAD1 Gene COMPARTMENTS Subcellular localization image for SDAD1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SDAD1: view

Pathways for SDAD1 Gene

SuperPathways for SDAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IEA --
GO:0015031 protein transport IEA --
GO:0030036 actin cytoskeleton organization IEA --
GO:0042273 ribosomal large subunit biogenesis ISS --
genes like me logo Genes that share ontologies with SDAD1: view

No data available for Pathways by source for SDAD1 Gene

Transcripts for SDAD1 Gene

Unigene Clusters for SDAD1 Gene

SDA1 domain containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDAD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for SDAD1 Gene

GeneLoc Exon Structure for
SDAD1
ECgene alternative splicing isoforms for
SDAD1

Expression for SDAD1 Gene

mRNA expression in normal human tissues for SDAD1 Gene

Protein differential expression in normal tissues for SDAD1 Gene

This gene is overexpressed in Lung (61.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDAD1 Gene

SOURCE GeneReport for Unigene cluster for SDAD1 Gene Hs.632604

mRNA Expression by UniProt/SwissProt for SDAD1 Gene

Q9NVU7-SDA1_HUMAN
Tissue specificity: Highly expressed in testis, kidney, spleen, brain and fetal tissues. Also expressed at lower level in heart, lung, liver, small intestine, ovary, uterus, mammary gland and placenta.
genes like me logo Genes that share expressions with SDAD1: view

Expression partners for SDAD1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SDAD1 Gene

Orthologs for SDAD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDAD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SDAD1 35
  • 91.12 (n)
  • 94.32 (a)
SDAD1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SDAD1 35
  • 89.59 (n)
  • 91.35 (a)
SDAD1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdad1 35
  • 87.82 (n)
  • 94.03 (a)
Sdad1 16
Sdad1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SDAD1 35
  • 99.71 (n)
  • 100 (a)
SDAD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sdad1 35
  • 86.78 (n)
  • 94.02 (a)
oppossum
(Monodelphis domestica)
Mammalia SDAD1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDAD1 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDAD1 35
  • 77.7 (n)
  • 83.67 (a)
SDAD1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SDAD1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sdad1 35
  • 74.31 (n)
  • 81.9 (a)
Str.17243 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398506 35
zebrafish
(Danio rerio)
Actinopterygii flj10498 35
sdad1 35
  • 73.24 (n)
  • 78.24 (a)
sdad1 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1827 35
fruit fly
(Drosophila melanogaster)
Insecta Mys45A 35
  • 57.21 (n)
  • 53.13 (a)
Mys45A 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pro-3 35
  • 51.27 (n)
  • 41.85 (a)
pro-3 36
  • 34 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL212W 35
  • 46.48 (n)
  • 38.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SDA1 36
  • 34 (a)
OneToOne
SDA1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4149 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6735 36
  • 55 (a)
OneToOne
Species with no ortholog for SDAD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDAD1 Gene

ENSEMBL:
Gene Tree for SDAD1 (if available)
TreeFam:
Gene Tree for SDAD1 (if available)

Paralogs for SDAD1 Gene

genes like me logo Genes that share paralogs with SDAD1: view

No data available for Paralogs for SDAD1 Gene

Variants for SDAD1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SDAD1 Gene

Q9NVU7-SDA1_HUMAN
Variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis (SAR). SAR is a common allergic disorder characterized by episodes of sneezing, rhinorrhea, and swelling of the nasal mucosa

Sequence variations from dbSNP and Humsavar for SDAD1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2273 -- 75,968,235(+) TCCTA(C/T)ACTGG intron-variant
rs7154 -- 75,950,030(-) GAATA(C/T)ATTTA utr-variant-3-prime
rs15480 -- 75,971,407(+) ACTTT(G/T)CTTCC reference, missense
rs15481 - 75,971,398(-) GTTCC(A/C)AAAAC reference, missense
rs533820 -- 75,950,247(+) AGTAA(A/G)AACCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SDAD1 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855

Relevant External Links for SDAD1 Gene

HapMap Linkage Disequilibrium report
SDAD1

Disorders for SDAD1 Gene

Relevant External Links for SDAD1

Genetic Association Database (GAD)
SDAD1
Human Genome Epidemiology (HuGE) Navigator
SDAD1

No disorders were found for SDAD1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SDAD1 Gene

Publications for SDAD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin A.I. … Ukraintseva S.V. (Aging (Albany NY) 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Expression and localization studies of hSDA, the human ortholog of the yeast SDA1 gene. (PMID: 14976432) Babbio F. … Privitera E. (Cell Cycle 2004) 3 4
  5. Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind. (PMID: 15607425) Fox M. … Reijo Pera R.A. (Genomics 2005) 3 4

Products for SDAD1 Gene

Sources for SDAD1 Gene

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