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Aliases for SDAD1 Gene

Aliases for SDAD1 Gene

  • SDA1 Domain Containing 1 2 3 5
  • SDA1 Domain-Containing Protein 1 4
  • Nucleolar Protein 130 4
  • NUC130 4
  • HSDA 4

External Ids for SDAD1 Gene

Previous GeneCards Identifiers for SDAD1 Gene

  • GC04M077330
  • GC04M077228
  • GC04M077090
  • GC04M076871
  • GC04M072623

Summaries for SDAD1 Gene

GeneCards Summary for SDAD1 Gene

SDAD1 (SDA1 Domain Containing 1) is a Protein Coding gene. Diseases associated with SDAD1 include Rhinitis and Allergic Rhinitis. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for SDAD1 Gene

  • Required for 60S pre-ribosomal subunits export to the cytoplasm.

Gene Wiki entry for SDAD1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDAD1 Gene

Genomics for SDAD1 Gene

Regulatory Elements for SDAD1 Gene

Enhancers for SDAD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F075989 0.2 ENCODE 30.7 +0.4 405 2.1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 SDAD1 NAAA THAP6 SCARB2 CDKL2 ART3 LOC101928809
GH04F076801 0.9 Ensembl ENCODE 26.8 -812.1 -812058 3.5 PKNOX1 ATF1 INSM2 KLF17 GLIS2 ZNF366 SCRT2 FOS CREM ZNF263 SDAD1 LOC105377289 PIR31989
GH04F076146 0.6 ENCODE 18.4 -157.2 -157210 2.5 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NUP54 SDAD1 ART3 THAP6 GC04P076146
GH04F076028 0.5 FANTOM5 16.5 -36.5 -36491 0.1 HDAC1 HDGF ATF1 KLF1 SIN3A ARID4B KLF17 GLIS2 ZFHX2 FOXK2 ART3 CXCL10 CXCL9 CXCL11 SDAD1 THAP6 NUP54 NAAA GC04M075923 RPL36P8
GH04F075728 0.6 Ensembl 16.4 +261.7 261662 1.0 ZNF202 ZBTB33 CHAMP1 SDAD1 THAP6 LOC105377284 RNU2-16P CDKL2 USO1 G3BP2 GC04P075797
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SDAD1 on UCSC Golden Path with GeneCards custom track

Promoters for SDAD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001432208 462 2200 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143

Genomic Location for SDAD1 Gene

Chromosome:
4
Start:
75,940,950 bp from pter
End:
75,990,962 bp from pter
Size:
50,013 bases
Orientation:
Minus strand

Genomic View for SDAD1 Gene

Genes around SDAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDAD1 Gene

Proteins for SDAD1 Gene

  • Protein details for SDAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVU7-SDA1_HUMAN
    Recommended name:
    Protein SDA1 homolog
    Protein Accession:
    Q9NVU7
    Secondary Accessions:
    • Q32Q11
    • Q68D52
    • Q7Z5U4
    • Q9H831
    • Q9H9P6

    Protein attributes for SDAD1 Gene

    Size:
    687 amino acids
    Molecular mass:
    79871 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • DAZL and PUM2 bind its 3-UTR mRNA, suggesting that these proteins may regulate its translation.
    SequenceCaution:
    • Sequence=AAI07896.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91648.1; Type=Frameshift; Positions=53; Evidence={ECO:0000305}; Sequence=BAB14177.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SDAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDAD1 Gene

Post-translational modifications for SDAD1 Gene

  • Ubiquitination at Lys 21
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for SDAD1
  • Santa Cruz Biotechnology (SCBT) Antibodies for SDAD1

No data available for DME Specific Peptides for SDAD1 Gene

Domains & Families for SDAD1 Gene

Protein Domains for SDAD1 Gene

Suggested Antigen Peptide Sequences for SDAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVU7

UniProtKB/Swiss-Prot:

SDA1_HUMAN :
  • Belongs to the SDA1 family.
Family:
  • Belongs to the SDA1 family.
genes like me logo Genes that share domains with SDAD1: view

No data available for Gene Families for SDAD1 Gene

Function for SDAD1 Gene

Molecular function for SDAD1 Gene

UniProtKB/Swiss-Prot Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.

Gene Ontology (GO) - Molecular Function for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SDAD1: view
genes like me logo Genes that share phenotypes with SDAD1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDAD1 Gene

Localization for SDAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDAD1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDAD1 Gene COMPARTMENTS Subcellular localization image for SDAD1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA 11790298
genes like me logo Genes that share ontologies with SDAD1: view

Pathways & Interactions for SDAD1 Gene

SuperPathways for SDAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IEA --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0030036 actin cytoskeleton organization IEA,IBA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with SDAD1: view

No data available for Pathways by source and SIGNOR curated interactions for SDAD1 Gene

Transcripts for SDAD1 Gene

Unigene Clusters for SDAD1 Gene

SDA1 domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for SDAD1 Gene

GeneLoc Exon Structure for
SDAD1
ECgene alternative splicing isoforms for
SDAD1

Expression for SDAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SDAD1 Gene

Protein differential expression in normal tissues from HIPED for SDAD1 Gene

This gene is overexpressed in Lung (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SDAD1 Gene



Protein tissue co-expression partners for SDAD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SDAD1 Gene:

SDAD1

SOURCE GeneReport for Unigene cluster for SDAD1 Gene:

Hs.632604

mRNA Expression by UniProt/SwissProt for SDAD1 Gene:

Q9NVU7-SDA1_HUMAN
Tissue specificity: Highly expressed in testis, kidney, spleen, brain and fetal tissues. Also expressed at lower level in heart, lung, liver, small intestine, ovary, uterus, mammary gland and placenta.
genes like me logo Genes that share expression patterns with SDAD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SDAD1 Gene

Orthologs for SDAD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDAD1 34 35
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia SDAD1 34 35
  • 91.12 (n)
dog
(Canis familiaris)
Mammalia SDAD1 34 35
  • 89.59 (n)
oppossum
(Monodelphis domestica)
Mammalia SDAD1 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdad1 34 16 35
  • 87.82 (n)
rat
(Rattus norvegicus)
Mammalia Sdad1 34
  • 86.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SDAD1 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDAD1 34 35
  • 77.7 (n)
lizard
(Anolis carolinensis)
Reptilia SDAD1 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sdad1 34
  • 74.31 (n)
Str.17243 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398506 34
zebrafish
(Danio rerio)
Actinopterygii sdad1 34 35
  • 73.24 (n)
flj10498 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1827 34
fruit fly
(Drosophila melanogaster)
Insecta Mys45A 34 35
  • 57.21 (n)
worm
(Caenorhabditis elegans)
Secernentea pro-3 34 35
  • 51.27 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL212W 34
  • 46.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SDA1 35 37
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6735 35
  • 55 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4149 34
Species where no ortholog for SDAD1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDAD1 Gene

ENSEMBL:
Gene Tree for SDAD1 (if available)
TreeFam:
Gene Tree for SDAD1 (if available)

Paralogs for SDAD1 Gene

genes like me logo Genes that share paralogs with SDAD1: view

No data available for Paralogs for SDAD1 Gene

Variants for SDAD1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SDAD1 Gene

SDA1_HUMAN-Q9NVU7
Variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis (SAR). SAR is a common allergic disorder characterized by episodes of sneezing, rhinorrhea, and swelling of the nasal mucosa.

Sequence variations from dbSNP and Humsavar for SDAD1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10008757 -- 75,981,883(+) CATTC(A/G)GCAAA intron-variant
rs10018471 -- 75,981,365(+) TACTG(C/G)TCCTA intron-variant
rs10021434 -- 75,982,142(+) ACATG(C/G)AGAAA intron-variant, upstream-variant-2KB
rs10023521 -- 75,961,652(+) GGAAA(A/T)TAAAA intron-variant
rs10025697 -- 75,961,417(+) TGAGT(G/T)TTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SDAD1 Gene

Variant ID Type Subtype PubMed ID
esv3449791 CNV insertion 20981092
nsv7363 OTHER inversion 18451855
nsv967764 CNV duplication 23825009

Variation tolerance for SDAD1 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.29; 92.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDAD1

Disorders for SDAD1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SDAD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rhinitis
  • runny nose
allergic rhinitis
  • atopic rhinitis
- elite association - COSMIC cancer census association via MalaCards
Search SDAD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SDAD1

Genetic Association Database (GAD)
SDAD1
Human Genome Epidemiology (HuGE) Navigator
SDAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDAD1
genes like me logo Genes that share disorders with SDAD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDAD1 Gene

Publications for SDAD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin A.I. … Ukraintseva S.V. (Aging (Albany NY) 2010) 3 46 64
  3. Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind. (PMID: 15607425) Fox M. … Reijo Pera R.A. (Genomics 2005) 3 4 64
  4. Association of a haplotype block spanning SDAD1 gene and CXC chemokine genes with allergic rhinitis. (PMID: 15753903) Zhang J. … Arinami T. (J. Allergy Clin. Immunol. 2005) 4 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SDAD1 Gene

Sources for SDAD1 Gene

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