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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCYL3 Gene

protein-coding   GIFtS: 50
GCID: GC01M169821

SCY1-like 3 (S. cerevisiae)

 Explore 3 diseases affiliated with
SCYL3 via our new
 Human Malady Compendium 
Biological research products
for SCYL3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SCY1-Like 3 (S. Cerevisiae)1 2     SCY1-Like Protein 32 3
PACE11 2 3 5     Ezrin-Binding Partner PACE-1 (PACE-1)2
PACE-11 2     Protein-Associating With The Carboxyl-Terminal Domain Of Ezrin2
Ezrin-Binding Protein PACE-12 3     

External Ids:    HGNC: 192851   Entrez Gene: 571472   Ensembl: ENSG000000004577   OMIM: 6081925   UniProtKB: Q8IZE33   

Export aliases for SCYL3 gene to outside databases

Previous GC identifers: GC01M166554 GC01M168088 GC01M141044


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCYL3:
This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the
C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing
results in multiple transcript variants encoding multiple isoforms. (provided by RefSeq, Jun 2012)

UniProtKB/Swiss-Prot: PACE1_HUMAN, Q8IZE3
Function: May play a role in regulating cell adhesion/migration complexes in migrating cells

Gene Wiki entry for SCYL3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCYL3 gene promoter:
         Elk-1   STAT1   c-Ets-1   Evi-1   GATA-1   CREB   MEF-2A   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCYL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCYL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCYL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.2   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q24.2

SCYL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCYL3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M169821:  view genomic region     (about GC identifiers)

Start:
169,821,804 bp from pter      End:
169,863,408 bp from pter
Size:
41,605 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PACE1_HUMAN, Q8IZE3 (See protein sequence)
Recommended Name: Protein-associating with the carboxyl-terminal domain of ezrin  
Size: 742 amino acids; 82857 Da
Subunit: Interacts with EZR/VIL2 C-terminal domain
Subcellular location: Cytoplasm. Golgi apparatus. Cell projection, lamellipodium. Note=Colocalized with EZR/VIL2, actin
and CD44 in lamellipodia
Secondary accessions: A8K8Z2 Q5THA6 Q5THA8 Q8IZN9 Q96C56 Q9UBK6
Alternative splicing: 2 isoforms:  Q8IZE3-1   Q8IZE3-2   

Explore the universe of human proteins at neXtProt for SCYL3: NX_Q8IZE3

Post-translational modifications:

  • May be myristoylated; myristoylation may target it to Golgi compartment1
  • Phosphorylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IZE3

  • SCYL3 Protein expression data from MOPED and PaxDb:    About this image 
    SCYL3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_065156.5  NP_851607.2  

    ENSEMBL proteins: 
     ENSP00000356745   ENSP00000356744   ENSP00000407993   ENSP00000356746  

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    Novus Biologicals SCYL3 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SCYL3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12651155
    GO:0005794Golgi apparatus IDA12651155
    GO:0030027lamellipodium IDA12651155

    SCYL3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SCYL3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q8IZE3

    ProtoNet protein and cluster: Q8IZE3

    1 Blocks protein family: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: PACE1_HUMAN, Q8IZE3
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 4 HEAT repeats
    Similarity: Contains 1 protein kinase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PACE1_HUMAN, Q8IZE3
    Function: May play a role in regulating cell adhesion/migration complexes in migrating cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12651155
    GO:0005524ATP binding IEA--
    GO:0016301NOT kinase activity IDA12651155
         
    SCYL3 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SCYL3:
     Decreased influenza A virus in  Decreased substrate adherent c  Elongated cells with protrusio  Increased cell death HMECs cel 
     Increased colony dispersion (i 

         1 MGI phenotypic allele for Scyl3 (no phenotypes)

    SCYL3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SCYL3 

    miRNA
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    hsa-miR-30c hsa-miR-3607-3p hsa-miR-4254 hsa-miR-875-3p hsa-miR-1263 hsa-let-7d hsa-miR-202 hsa-miR-1271
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    In Situ Assay
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCYL3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SCYL3 (Q8IZE31, 3 ENSP000003567444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZRP153111, 3, ENSP000003389344EBI-1380680,EBI-1056902 I2D: score=4 STRING: ENSP00000338934
    CD44P160703, ENSP000002783854I2D: score=1 STRING: ENSP00000278385
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IEA--
    GO:0016477cell migration NAS12651155

    SCYL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCYL3
    Search CenterWatch for drugs/clinical trials and news about SCYL3 / PACE1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for SCYL3 gene (2 alternative transcripts): 
    NM_020423.6  NM_181093.3  

    Unigene Cluster for SCYL3:

    SCY1-like 3 (S. cerevisiae)
    Hs.435560  [show with all ESTs]
    Unigene Representative Sequence: BX647352
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367771 ENST00000367770 ENST00000423670 ENST00000470238 ENST00000367772(uc010plw.1 uc001ggs.2 uc001ggt.2)


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    hsa-miR-30c hsa-miR-3607-3p hsa-miR-4254 hsa-miR-875-3p hsa-miR-1263 hsa-let-7d hsa-miR-202 hsa-miR-1271
    SwitchGear 3'UTR luciferase reporter plasmidSCYL3 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF540957.1 AK292507.1 AK304481.1 AL117233.1 AY144493.1 BC014662.1 BX647352.1 

    8 DOTS entries:

    DT.95187885  DT.314364  DT.100022323  DT.315880  DT.121415893  DT.101976752  DT.40204419  DT.91812976 

    24/145 AceView cDNA sequences (see all 145):

    AA767370 AW001741 AI283918 AI567424 CR606380 AA235505 AW612152 BX109929 
    AI825240 AA767868 BF725301 AA424589 BF002820 BQ447450 AA479494 AA902727 
    BU164434 AA424634 AW591590 AI133233 CD722162 N31489 AL603263 BQ182818 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SCYL3 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:                                -     -                                               -                                                         
    SP2:                                -     -                                               -                                         -               
    SP3:                    -           -     -                                               -                                                         
    SP4:                                                                                                                                                
    SP5:        -     -     -           -     -                                                                                                         


    ECgene alternative splicing isoforms for SCYL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCYL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGTACATTG
    SCYL3 Expression
    About this image
    See SCYL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCYL3

    SOURCE GeneReport for Unigene cluster: Hs.435560

    UniProtKB/Swiss-Prot: PACE1_HUMAN, Q8IZE3
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SCYL3 gene from 4/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SCYL31 SCY1-like 3 (S. cerevisiae) 69.05(n)
    67.95(a)
      424396  NM_001012595.2  NP_001012613.2 
    lizard
    (Anolis carolinensis)
    Reptilia SCYL36
    SCYL16
    --
    55(a)
    11(a)
    1 ↔ 1
    possible ortholog
    GL343300.1(1406143-1420581)
    GL343717.1(228284-235164)
    zebrafish
    (Danio rerio)
    Actinopterygii BC044195.12   -- 72.05(n)   323839  BC044195.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG13441 CG1344 44.44(n)
    33.09(a)
      35500  NM_136331.2  NP_610175.2 


    ENSEMBL Gene Tree for SCYL3 (if available)
    TreeFam Gene Tree for SCYL3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCYL3 gene
    SCYL12  

    SCYL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/774 NCBI SNPs in SCYL3 are shown (see all 774    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57786331,2
    C--141056617(+) gtctc-/AAaaaaa 1 -- int11Minor allele frequency- AA:0.00NA 2
    rs168627161,2
    C,F,H--169822850(+) CATCTA/GTTGTC 2 -- ut31 ese310Minor allele frequency- G:0.01NA NS EA CSA WA EU 1989
    rs2012384921,2
    F--169822851(+) ATCTAT/CTGTCA 2 -- ut311Minor allele frequency- C:0.00EU 1309
    rs1866214751,2
    C--169822857(+) TGTCAA/CCAGTT 4 W C mis10--------
    rs1902399481,2
    C--169822892(+) TTCTTC/GTTCCC 4 Q E mis11Minor allele frequency- G:0.00EU 1323
    rs1824332441,2
    --169822975(+) ATACGC/TAAATT 2 -- int10--------
    rs120777941,2
    C,F,H--169822983(+) ATTTGA/TAAAAG 2 -- int19Minor allele frequency- T:0.04NS EA NA WA 1208
    rs1411044221,2
    --169823002(+) TAAAAC/TTTATC 2 -- int10--------
    rs1425372681,2
    --169823084(+) GATTAC/TAAAAC 2 -- int10--------
    rs1505748731,2
    --169823177(+) CTTTT-/TTTTC 
            
    TTTTC
    2 -- int10--------

    HapMap Linkage Disequilibrium report for SCYL3 (169821804 - 169863408 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SCYL3
         1 CNV: 3319

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SCYL3 for disorders           About GeneDecksing

    OMIM gene information: 608192    OMIM disorders: --

    3 diseases for SCYL3:    About MalaCards
    t-cell leukemia    leukemia    malaria

    Human Genome Epidemiology (HuGE) Navigator: SCYL3 (7 documents)

    Export disorders for SCYL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCYL3 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SCYL3)
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    1. PACE-1, a novel protein that interacts with the C-terminal domain of ezrin. (PubMed id 12651155)1, 2, 3, 9 Sullivan A.... Thorne R.F. (2003)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Analysis on the susceptibility genes in two chinese pe digrees with familial Parkinson's disease. (PubMed id 21188226)1 Xu C....Kamada M. (2010)
    9. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1 Cheung C.L....Kung A.W. (2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57147 HGNC: 19285 AceView: PACE-1 Ensembl:ENSG00000000457 euGenes: HUgn57147
    ECgene: SCYL3 H-InvDB: SCYL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCYL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCYL3 gene:
    Search GeneIP for patents involving SCYL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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