Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SCYL3 Gene

Aliases for SCYL3 Gene

  • SCY1-Like 3 (S. Cerevisiae) 2 3
  • PACE1 3 4 6
  • Ezrin-Binding Protein PACE-1 3 4
  • SCY1-Like Protein 3 3 4
  • Protein-Associating With The Carboxyl-Terminal Domain Of Ezrin 3
  • Ezrin-Binding Partner PACE-1 (PACE-1) 3
  • Ezrin-Binding Partner PACE-1 2
  • PACE-1 3

External Ids for SCYL3 Gene

Summaries for SCYL3 Gene

Entrez Gene Summary for SCYL3 Gene

  • This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for SCYL3 Gene

SCYL3 (SCY1-Like 3 (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include kinase activity.

UniProtKB/Swiss-Prot for SCYL3 Gene

  • May play a role in regulating cell adhesion/migration complexes in migrating cells.

Gene Wiki entry for SCYL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCYL3 Gene

Genomics for SCYL3 Gene

Genomic Location for SCYL3 Gene

Start:
169,849,631 bp from pter
End:
169,894,267 bp from pter
Size:
44,637 bases
Orientation:
Minus strand

Genomic View for SCYL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCYL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCYL3 Gene

Regulatory Elements for SCYL3 Gene

Proteins for SCYL3 Gene

  • Protein details for SCYL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZE3-PACE1_HUMAN
    Recommended name:
    Protein-associating with the carboxyl-terminal domain of ezrin
    Protein Accession:
    Q8IZE3
    Secondary Accessions:
    • A8K8Z2
    • Q5THA6
    • Q5THA8
    • Q8IZN9
    • Q96C56
    • Q9UBK6

    Protein attributes for SCYL3 Gene

    Size:
    742 amino acids
    Molecular mass:
    82857 Da
    Quaternary structure:
    • Interacts with EZR/VIL2 C-terminal domain.

    Alternative splice isoforms for SCYL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCYL3 Gene

Proteomics data for SCYL3 Gene at MOPED

Post-translational modifications for SCYL3 Gene

Other Protein References for SCYL3 Gene

No data available for DME Specific Peptides for SCYL3 Gene

Domains for SCYL3 Gene

Protein Domains for SCYL3 Gene

UniProtKB/Swiss-Prot:

PACE1_HUMAN
Domain:
  • The protein kinase domain is predicted to be catalytically inactive:
    • Q8IZE3
  • Contains 1 protein kinase domain.:
    • Q8IZE3
Family:
  • Belongs to the protein kinase superfamily.:
    • Q8IZE3
Similarity:
  • Contains 4 HEAT repeats.:
    • Q8IZE3
genes like me logo Genes that share domains with SCYL3: view

No data available for Gene Families for SCYL3 Gene

Function for SCYL3 Gene

Molecular function for SCYL3 Gene

UniProtKB/Swiss-Prot Function: May play a role in regulating cell adhesion/migration complexes in migrating cells.

Gene Ontology (GO) - Molecular Function for SCYL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0005488 binding --
GO:0005515 protein binding IPI 12651155
GO:0005524 ATP binding IEA --
GO:0016301 NOT kinase activity IDA 12651155
genes like me logo Genes that share ontologies with SCYL3: view
genes like me logo Genes that share phenotypes with SCYL3: view

miRNA for SCYL3 Gene

miRTarBase miRNAs that target SCYL3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCYL3 Gene

Localization for SCYL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCYL3 Gene

Cytoplasm. Golgi apparatus. Cell projection, lamellipodium. Note=Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCYL3 Gene COMPARTMENTS Subcellular localization image for SCYL3 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
plasma membrane 3
extracellular 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SCYL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12651155
GO:0005794 Golgi apparatus IDA 12651155
GO:0030027 lamellipodium IDA 12651155
genes like me logo Genes that share ontologies with SCYL3: view

Pathways for SCYL3 Gene

SuperPathways for SCYL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCYL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016477 cell migration NAS 12651155
genes like me logo Genes that share ontologies with SCYL3: view

No data available for Pathways by source for SCYL3 Gene

Transcripts for SCYL3 Gene

Unigene Clusters for SCYL3 Gene

SCY1-like 3 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCYL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: - - - - -
SP6: -
SP7: - -
SP8: - -
SP9: -

Relevant External Links for SCYL3 Gene

GeneLoc Exon Structure for
SCYL3
ECgene alternative splicing isoforms for
SCYL3

Expression for SCYL3 Gene

mRNA expression in normal human tissues for SCYL3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCYL3 Gene

SOURCE GeneReport for Unigene cluster for SCYL3 Gene Hs.435560

mRNA Expression by UniProt/SwissProt for SCYL3 Gene

Q8IZE3-PACE1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with SCYL3: view

Orthologs for SCYL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCYL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCYL3 36
  • 99.46 (n)
  • 98.92 (a)
SCYL3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCYL3 36
  • 86.31 (n)
  • 84.31 (a)
SCYL3 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCYL3 36
  • 87.72 (n)
  • 85.83 (a)
SCYL3 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scyl3 36
  • 81.97 (n)
  • 80.58 (a)
Scyl3 16
Scyl3 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCYL3 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCYL3 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scyl3 36
  • 82.33 (n)
  • 81.47 (a)
chicken
(Gallus gallus)
Aves SCYL3 36
  • 69.47 (n)
  • 68.69 (a)
SCYL3 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCYL3 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scyl3 36
  • 61.13 (n)
  • 58.6 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
scyl3 36
  • 57.41 (n)
  • 55.25 (a)
scyl3 37
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1344 37
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToOne
Species with no ortholog for SCYL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCYL3 Gene

ENSEMBL:
Gene Tree for SCYL3 (if available)
TreeFam:
Gene Tree for SCYL3 (if available)

Paralogs for SCYL3 Gene

No data available for Paralogs for SCYL3 Gene

Variants for SCYL3 Gene

Sequence variations from dbSNP and Humsavar for SCYL3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1496 -- 169,858,717(-) TGGAG(C/T)TGAAA intron-variant
rs717481 -- 169,858,615(-) CCAGT(C/T)ATATA intron-variant
rs732185 -- 169,861,609(-) taaaa(C/T)aataa intron-variant
rs882595 -- 169,860,674(+) GCCCA(C/T)TGAAT intron-variant
rs882596 -- 169,860,689(+) TAATC(A/T)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCYL3 Gene

Variant ID Type Subtype PubMed ID
dgv146e1 CNV Complex 17122850
nsv428268 CNV Gain+Loss 18775914
nsv872542 CNV Gain 21882294
esv2719428 CNV Deletion 23290073
esv2662442 CNV Deletion 23128226

Relevant External Links for SCYL3 Gene

HapMap Linkage Disequilibrium report
SCYL3

Disorders for SCYL3 Gene

Relevant External Links for SCYL3

Genetic Association Database (GAD)
SCYL3
Human Genome Epidemiology (HuGE) Navigator
SCYL3
genes like me logo Genes that share disorders with SCYL3: view

No data available for UniProtKB/Swiss-Prot for SCYL3 Gene

Publications for SCYL3 Gene

  1. PACE-1, a novel protein that interacts with the C-terminal domain of ezrin. (PMID: 12651155) Sullivan A. … Thorne R.F. (Exp. Cell Res. 2003) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3 49
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for SCYL3 Gene

  • Addgene plasmids for SCYL3

Sources for SCYL3 Gene

Back to Top

Content