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Aliases for SCYL3 Gene

Aliases for SCYL3 Gene

  • SCY1 Like Pseudokinase 3 2 3 5
  • Ezrin-Binding Protein PACE-1 3 4
  • SCY1-Like, Kinase-Like 3 2 3
  • SCY1-Like Protein 3 3 4
  • PACE1 3 4
  • Protein-Associating With The Carboxyl-Terminal Domain Of Ezrin 3
  • Ezrin-Binding Partner PACE-1 (PACE-1) 3
  • Ezrin-Binding Partner PACE-1 2
  • SCY1-Like 3 (S. Cerevisiae) 2
  • SCY1-Like 3 3
  • PACE-1 3

External Ids for SCYL3 Gene

Previous GeneCards Identifiers for SCYL3 Gene

  • GC01M166554
  • GC01M168088
  • GC01M141044

Summaries for SCYL3 Gene

Entrez Gene Summary for SCYL3 Gene

  • This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for SCYL3 Gene

SCYL3 (SCY1 Like Pseudokinase 3) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and binding. An important paralog of this gene is SCYL1.

UniProtKB/Swiss-Prot for SCYL3 Gene

  • May play a role in regulating cell adhesion/migration complexes in migrating cells.

Gene Wiki entry for SCYL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCYL3 Gene

Genomics for SCYL3 Gene

Regulatory Elements for SCYL3 Gene

Enhancers for SCYL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F169362 1.4 Ensembl ENCODE 27 +528.3 528279 7.2 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 NME7 SCYL3 RN7SL333P CCDC181 METTL18 BLZF1 ENSG00000235575
GH01F169793 1.1 ENCODE 20.7 +99.2 99204 2.3 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 DEK METTL18 SCYL3 GORAB C1orf112 KIFAP3 RN7SL333P
GH01F169311 1.3 Ensembl ENCODE 14.5 +581.9 581901 1.1 PKNOX1 ATF1 ARNT ZNF2 GATA2 FOS JUNB REST CREB3 MBD2 NME7 SCYL3 RN7SL333P ENSG00000235575 BLZF1
GH01F169889 1.8 FANTOM5 Ensembl ENCODE 10.1 +2.0 2031 5.5 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 METTL18 KIFAP3 MRPS10P1 ENSG00000230704 ENSG00000232959 HAUS4P1 RPL29P7 GORAB SCYL3 C1orf112
GH01F169482 1.2 ENCODE 14 +408.7 408697 5.7 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SCYL3 NME7 CCDC181 ENSG00000213062 METTL18 PIR61656
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCYL3 on UCSC Golden Path with GeneCards custom track

Promoters for SCYL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000287083 567 2601 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for SCYL3 Gene

Chromosome:
1
Start:
169,849,631 bp from pter
End:
169,894,267 bp from pter
Size:
44,637 bases
Orientation:
Minus strand

Genomic View for SCYL3 Gene

Genes around SCYL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCYL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCYL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCYL3 Gene

Proteins for SCYL3 Gene

  • Protein details for SCYL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZE3-PACE1_HUMAN
    Recommended name:
    Protein-associating with the carboxyl-terminal domain of ezrin
    Protein Accession:
    Q8IZE3
    Secondary Accessions:
    • A8K8Z2
    • Q5THA6
    • Q5THA8
    • Q8IZN9
    • Q96C56
    • Q9UBK6

    Protein attributes for SCYL3 Gene

    Size:
    742 amino acids
    Molecular mass:
    82857 Da
    Quaternary structure:
    • Interacts with EZR/VIL2 C-terminal domain.

    Alternative splice isoforms for SCYL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCYL3 Gene

Post-translational modifications for SCYL3 Gene

No data available for DME Specific Peptides for SCYL3 Gene

Domains & Families for SCYL3 Gene

Gene Families for SCYL3 Gene

Protein Domains for SCYL3 Gene

Suggested Antigen Peptide Sequences for SCYL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZE3

UniProtKB/Swiss-Prot:

PACE1_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily.
  • Contains 4 HEAT repeats.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily.
Similarity:
  • Contains 4 HEAT repeats.
genes like me logo Genes that share domains with SCYL3: view

Function for SCYL3 Gene

Molecular function for SCYL3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulating cell adhesion/migration complexes in migrating cells.

Gene Ontology (GO) - Molecular Function for SCYL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12651155
GO:0005524 ATP binding IEA --
GO:0016301 NOT kinase activity IDA 12651155
genes like me logo Genes that share ontologies with SCYL3: view
genes like me logo Genes that share phenotypes with SCYL3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCYL3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SCYL3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCYL3 Gene

Localization for SCYL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCYL3 Gene

Cytoplasm. Golgi apparatus. Cell projection, lamellipodium. Note=Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCYL3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
cytosol 3
extracellular 2
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SCYL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 12651155
GO:0005794 Golgi apparatus IEA,IDA 12651155
GO:0030027 lamellipodium IEA,IDA 12651155
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with SCYL3: view

Pathways & Interactions for SCYL3 Gene

SuperPathways for SCYL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCYL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016477 cell migration NAS 12651155
genes like me logo Genes that share ontologies with SCYL3: view

No data available for Pathways by source and SIGNOR curated interactions for SCYL3 Gene

Transcripts for SCYL3 Gene

Unigene Clusters for SCYL3 Gene

SCY1-like 3 (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SCYL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCYL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: - - - - -
SP6: -
SP7: - -
SP8: - -
SP9: -

Relevant External Links for SCYL3 Gene

GeneLoc Exon Structure for
SCYL3
ECgene alternative splicing isoforms for
SCYL3

Expression for SCYL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCYL3 Gene

Protein differential expression in normal tissues from HIPED for SCYL3 Gene

This gene is overexpressed in Salivary gland (23.2), Stomach (12.2), Breast (9.5), and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCYL3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SCYL3 Gene:

SCYL3

SOURCE GeneReport for Unigene cluster for SCYL3 Gene:

Hs.435560

mRNA Expression by UniProt/SwissProt for SCYL3 Gene:

Q8IZE3-PACE1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SCYL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for SCYL3 Gene

Orthologs for SCYL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCYL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCYL3 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia SCYL3 34 35
  • 87.72 (n)
cow
(Bos Taurus)
Mammalia SCYL3 34 35
  • 86.31 (n)
rat
(Rattus norvegicus)
Mammalia Scyl3 34
  • 82.33 (n)
mouse
(Mus musculus)
Mammalia Scyl3 34 16 35
  • 81.97 (n)
oppossum
(Monodelphis domestica)
Mammalia SCYL3 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCYL3 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCYL3 34 35
  • 69.47 (n)
lizard
(Anolis carolinensis)
Reptilia SCYL3 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scyl3 34
  • 61.13 (n)
zebrafish
(Danio rerio)
Actinopterygii scyl3 34 35
  • 57.41 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG1344 35
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for SCYL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCYL3 Gene

ENSEMBL:
Gene Tree for SCYL3 (if available)
TreeFam:
Gene Tree for SCYL3 (if available)

Paralogs for SCYL3 Gene

Paralogs for SCYL3 Gene

genes like me logo Genes that share paralogs with SCYL3: view

Variants for SCYL3 Gene

Sequence variations from dbSNP and Humsavar for SCYL3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157296 -- 169,896,239(+) cctct(A/G)tgtgg upstream-variant-2KB
rs10158922 -- 169,884,298(+) tattt(C/T)gtttt intron-variant
rs10159425 -- 169,882,968(+) ccaca(C/T)tgtgg intron-variant
rs1046058 -- 169,853,402(-) AATTC(C/T)GGAAG intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs10489169 -- 169,887,082(-) AAAAA(C/G)TAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCYL3 Gene

Variant ID Type Subtype PubMed ID
nsv954764 CNV deletion 24416366
nsv428268 CNV gain+loss 18775914
nsv1078878 OTHER inversion 25765185
esv8223 CNV gain 19470904
esv3542422 CNV deletion 23714750
esv2758976 CNV gain+loss 17122850
esv2719428 CNV deletion 23290073
esv2662442 CNV deletion 23128226

Variation tolerance for SCYL3 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.89; 67.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCYL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCYL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCYL3 Gene

Disorders for SCYL3 Gene

Relevant External Links for SCYL3

Genetic Association Database (GAD)
SCYL3
Human Genome Epidemiology (HuGE) Navigator
SCYL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCYL3

No disorders were found for SCYL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCYL3 Gene

Publications for SCYL3 Gene

  1. PACE-1, a novel protein that interacts with the C-terminal domain of ezrin. (PMID: 12651155) Sullivan A. … Thorne R.F. (Exp. Cell Res. 2003) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3 46 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SCYL3 Gene

Sources for SCYL3 Gene

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