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SCYL3 Gene

protein-coding   GIFtS: 55
GCID: GC01M169821

SCY1-Like 3 (S. Cerevisiae)

  Search for SCYL3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SCY1-Like 3 (S. Cerevisiae)1 2     Ezrin-Binding Partner PACE-11
PACE12 3 5     PACE-12
Ezrin-Binding Protein PACE-12 3     Ezrin-Binding Partner PACE-1 (PACE-1)2
SCY1-Like Protein 32 3     Protein-Associating With The Carboxyl-Terminal Domain Of Ezrin2

External Ids:    HGNC: 192851   Entrez Gene: 571472   Ensembl: ENSG000000004577   OMIM: 6081925   UniProtKB: Q8IZE33   

Export aliases for SCYL3 gene to outside databases

Previous GC identifers: GC01M166554 GC01M168088 GC01M141044


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCYL3 Gene:
This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the
C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative
splicing results in multiple transcript variants encoding multiple isoforms. (provided by RefSeq, Jun 2012)

GeneCards Summary for SCYL3 Gene:
SCYL3 (SCY1-like 3 (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include kinase activity.

UniProtKB/Swiss-Prot: PACE1_HUMAN, Q8IZE3
Function: May play a role in regulating cell adhesion/migration complexes in migrating cells

Gene Wiki entry for SCYL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCYL3 gene promoter:
         Elk-1   STAT1   c-Ets-1   Evi-1   GATA-1   CREB   MEF-2A   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCYL3 promoter sequence
   Search Chromatin IP Primers for SCYL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCYL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.2   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q24.2

SCYL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCYL3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M169821:  view genomic region     (about GC identifiers)

Start:
169,818,772 bp from pter      End:
169,863,408 bp from pter
Size:
44,637 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PACE1_HUMAN, Q8IZE3 (See protein sequence)
Recommended Name: Protein-associating with the carboxyl-terminal domain of ezrin  
Size: 742 amino acids; 82857 Da
Subunit: Interacts with EZR/VIL2 C-terminal domain
Secondary accessions: A8K8Z2 Q5THA6 Q5THA8 Q8IZN9 Q96C56 Q9UBK6
Alternative splicing: 2 isoforms:  Q8IZE3-1   Q8IZE3-2   

Explore the universe of human proteins at neXtProt for SCYL3: NX_Q8IZE3

Explore proteomics data for SCYL3 at MOPED

Post-translational modifications: 

  • May be myristoylated; myristoylation may target it to Golgi compartment1
  • Phosphorylated1
  • Ubiquitination2 at Lys272
  • Modification sites at PhosphoSitePlus

  • See SCYL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_065156.5  NP_851607.2  

    ENSEMBL proteins: 
     ENSP00000356745   ENSP00000356744   ENSP00000407993   ENSP00000356746  

    SCYL3 Human Recombinant Protein Products:

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    Novus Biologicals SCYL3 Proteins
    Novus Biologicals SCYL3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCYL3

     
    Search eBioscience for Proteins for SCYL3 

    SCYL3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    SCYL3 Assay Products:

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    Search eBioscience for ELISAs for SCYL3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q8IZE3

    ProtoNet protein and cluster: Q8IZE3

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: PACE1_HUMAN, Q8IZE3
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 4 HEAT repeats
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with SCYL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PACE1_HUMAN, Q8IZE3
    Function: May play a role in regulating cell adhesion/migration complexes in migrating cells

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0005488binding ----
    GO:0005515protein binding IPI12651155
    GO:0005524ATP binding IEA--
    GO:0016301NOT kinase activity IDA12651155
         
    Find genes that share ontologies with SCYL3           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SCYL3:
     Decreased influenza A virus in  Decreased substrate adherent c  Elongated cells with protrusio  Increased cell death HMECs cel 
     Increased colony dispersion (i 

         1 MGI phenotypic allele for Scyl3 (no phenotypes)

    Find genes that share phenotypes with SCYL3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCYL3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SCYL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCYL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCYL3

    miRNA
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    miRTarBase miRNAs that target SCYL3:
    hsa-mir-149-5p (MIRT045388)

    Block miRNA regulation of human, mouse, rat SCYL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCYL3 (see all 31):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-4254 hsa-miR-875-3p hsa-miR-1263 hsa-let-7d hsa-miR-202 hsa-miR-1271
    SwitchGear 3'UTR luciferase reporter plasmidSCYL3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SCYL3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SCYL3 (NM_020423)
    Sino Biological Human cDNA Clone for SCYL3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCYL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL3
    Addgene plasmids for SCYL3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PACE1_HUMAN, Q8IZE3: Cytoplasm. Golgi apparatus. Cell projection, lamellipodium. Note=Colocalized with EZR/VIL2,
    actin and CD44 in lamellipodia
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    plasma membrane3
    extracellular2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12651155
    GO:0005794Golgi apparatus IDA12651155
    GO:0030027lamellipodium IDA12651155

    Find genes that share ontologies with SCYL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCYL3
    Interactions:

        Search GeneGlobe Interaction Network for SCYL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SCYL3 (Q8IZE31, 3 ENSP000003567444) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZRP153111, 3, ENSP000003389344EBI-1380680,EBI-1056902 I2D: score=4 STRING: ENSP00000338934
    CD44P160703, ENSP000002783854I2D: score=1 STRING: ENSP00000278385
    ARCN1ENSP000002640284STRING: ENSP00000264028
    RANENSP000003961274STRING: ENSP00000396127
    RANGAP1ENSP000003485774STRING: ENSP00000348577
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IEA--
    GO:0016477cell migration NAS12651155

    Find genes that share ontologies with SCYL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCYL3 (PACE1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCYL3 gene (2 alternative transcripts): 
    NM_020423.6  NM_181093.3  

    Unigene Cluster for SCYL3:

    SCY1-like 3 (S. cerevisiae)
    Hs.435560  [show with all ESTs]
    Unigene Representative Sequence: BX647352
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367771 ENST00000367770 ENST00000423670 ENST00000470238 ENST00000367772(uc010plw.1 uc001ggs.2 uc001ggt.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat SCYL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCYL3 (see all 31):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-4254 hsa-miR-875-3p hsa-miR-1263 hsa-let-7d hsa-miR-202 hsa-miR-1271
    SwitchGear 3'UTR luciferase reporter plasmidSCYL3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SCYL3
    Clone
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    OriGene ORF clones in mouse, rat for SCYL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SCYL3 (NM_020423)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCYL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL3
    Addgene plasmids for SCYL3 
    Primer
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    OriGene qPCR primer pairs and template standards for SCYL3
    OriGene qSTAR qPCR primer pairs in human, mouse for SCYL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCYL3
      QuantiTect SYBR Green Assays in human, mouse, rat SCYL3
      QuantiFast Probe-based Assays in human, mouse, rat SCYL3

    Additional mRNA sequence: 

    AF540957.1 AK292507.1 AK304481.1 AL117233.1 AY144493.1 BC014662.1 BX647352.1 

    10 DOTS entries:

    DT.95187885  DT.314364  DT.100022323  DT.315880  DT.121415893  DT.101976752  DT.40204419  DT.100790410 
    DT.91812976  DT.95092964 

    Selected AceView cDNA sequences (see all 145):

    CR606380 AI283918 AI246165 N42797 AA235505 BM683585 AA424589 AW612152 
    AW001741 AA767370 AI133233 AW591590 N31489 BQ182818 BQ716833 BU164434 
    BG548325 AA767868 CD722162 AA424634 BX109929 BM990000 BF725301 AI567424 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SCYL3 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:                                -     -                                               -                                                         
    SP2:                                -     -                                               -                                         -               
    SP3:                    -           -     -                                               -                                                         
    SP4:                                                                                                                                                
    SP5:        -     -     -           -     -                                                                                                         


    ECgene alternative splicing isoforms for SCYL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCYL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTACATTG
    SCYL3 Expression
    About this image

    SCYL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCYL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435560

    UniProtKB/Swiss-Prot: PACE1_HUMAN, Q8IZE3
    Tissue specificity: Ubiquitously expressed

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    QuantiFast Probe-based Assays in human, mouse, rat SCYL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SCYL3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scyl31 , 5 SCY1-like 3 (S. cerevisiae)1, 5 81.97(n)1
    80.58(a)1
      1 (71.23 cM)5
    2408801  NM_001286002.11  NP_001272931.11 
     1639291005 
    chicken
    (Gallus gallus)
    Aves SCYL31 SCY1-like 3 (S. cerevisiae) 69.47(n)
    68.69(a)
      424396  NM_001012595.2  NP_001012613.2 
    lizard
    (Anolis carolinensis)
    Reptilia SCYL36
    SCY1-like 3 (S. cerevisiae)
    56(a)
    1 ↔ 1
    GL343300.1(1401211-1427034)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia scyl31 SCY1-like 3 61.13(n)
    58.6(a)
      100038067  XM_002933784.2  XP_002933830.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044195.12   -- 72.05(n)   323839  BC044195.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG13446
    --
    26(a)
    1 ↔ 1
    2R(1541181-1544283)


    ENSEMBL Gene Tree for SCYL3 (if available)
    TreeFam Gene Tree for SCYL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCYL3 (see all 939)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs168627161,2
    C,F,H--169822850(+) CATCTA/GTTGTC 2 -- ut31 ese310Minor allele frequency- G:0.01NA NS EA CSA WA EU 1989
    rs2012384921,2
    C,F--169822851(+) ATCTAT/CTGTCA 2 -- ut311Minor allele frequency- C:0.00EU 1309
    rs1866214751,2
    C--169822857(+) TGTCAA/CCAGTT 4 W C mis10--------
    rs1902399481,2
    C--169822892(+) TTCTTC/GTTCCC 4 Q E mis11Minor allele frequency- G:0.00EU 1323
    rs3755681581,2
    C--169822973(+) TCATAC/TGCAAA 2 -- int10--------
    rs1824332441,2
    --169822975(+) ATACGC/TAAATT 2 -- int10--------
    rs120777941,2
    C,F,H--169822983(+) ATTTGA/TAAAAG 2 -- int19Minor allele frequency- T:0.04NS EA NA WA 1208
    rs1411044221,2
    C--169823002(+) TAAAAC/TTTATC 2 -- int10--------
    rs3717857701,2
    C--169823047(+) AAATA-/ACTTAG
    AGCTCTAAC
    AGAAA
    2 -- int10--------
    rs1425372681,2
    --169823084(+) GATTAC/TAAAAC 2 -- int10--------

    HapMap Linkage Disequilibrium report for SCYL3 (169818772 - 169863408 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SCYL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662442CNV Deletion23128226
    esv2719428CNV Deletion23290073
    nsv872542CNV Gain21882294
    nsv428268CNV Gain+Loss18775914
    dgv146e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCYL3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608192    OMIM disorders: --


    Find genes that share disorders with SCYL3           About GenesLikeMe

    Genetic Association Database (GAD): SCYL3
    Human Genome Epidemiology (HuGE) Navigator: SCYL3 (7 documents)

    Export disorders for SCYL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCYL3 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SCYL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PACE-1, a novel protein that interacts with the C-terminal domain of ezrin. (PubMed id 12651155)1, 2, 3, 9 Sullivan A.... Thorne R.F. (Exp. Cell Res. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (Hum. Mol. Genet. 2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57147 HGNC: 19285 AceView: PACE-1 Ensembl:ENSG00000000457 euGenes: HUgn57147
    ECgene: SCYL3 H-InvDB: SCYL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCYL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCYL3 gene:
    Search GeneIP for patents involving SCYL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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