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Aliases for SCYL2 Gene

Aliases for SCYL2 Gene

  • SCY1-Like 2 (S. Cerevisiae) 2 3
  • Coated Vesicle-Associated Kinase Of 104 KDa 3 4
  • CVAK104 3 4
  • SCY1-Like Protein 2 3
  • KIAA1360 4

External Ids for SCYL2 Gene

Summaries for SCYL2 Gene

GeneCards Summary for SCYL2 Gene

SCYL2 (SCY1-Like 2 (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include receptor binding and protein kinase activity.

UniProtKB/Swiss-Prot for SCYL2 Gene

  • Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system.

Gene Wiki entry for SCYL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCYL2 Gene

Genomics for SCYL2 Gene

Genomic Location for SCYL2 Gene

Start:
100,267,140 bp from pter
End:
100,341,724 bp from pter
Size:
74,585 bases
Orientation:
Plus strand

Genomic View for SCYL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCYL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCYL2 Gene

Regulatory Elements for SCYL2 Gene

Proteins for SCYL2 Gene

  • Protein details for SCYL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3W7-SCYL2_HUMAN
    Recommended name:
    SCY1-like protein 2
    Protein Accession:
    Q6P3W7
    Secondary Accessions:
    • A8KAB5
    • Q96EF4
    • Q96ST4
    • Q9H7V5
    • Q9NVH3
    • Q9P2I7

    Protein attributes for SCYL2 Gene

    Size:
    929 amino acids
    Molecular mass:
    103709 Da
    Quaternary structure:
    • Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex.
    SequenceCaution:
    • Sequence=BAA91778.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14869.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55194.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SCYL2 Gene

Proteomics data for SCYL2 Gene at MOPED

Post-translational modifications for SCYL2 Gene

  • According to PubMed:15809293, autophosphorylated in presence of poly-L-lysine
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCYL2 Gene

No data available for DME Specific Peptides for SCYL2 Gene

Domains for SCYL2 Gene

Gene Families for SCYL2 Gene

Protein Domains for SCYL2 Gene

UniProtKB/Swiss-Prot:

SCYL2_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q6P3W7
Family:
  • Belongs to the protein kinase superfamily.:
    • Q6P3W7
Similarity:
  • Contains 1 HEAT repeat.:
    • Q6P3W7
genes like me logo Genes that share domains with SCYL2: view

Function for SCYL2 Gene

Molecular function for SCYL2 Gene

UniProtKB/Swiss-Prot Function: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system.

Gene Ontology (GO) - Molecular Function for SCYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005102 receptor binding IPI 19643732
GO:0005488 binding --
GO:0005515 protein binding IPI 19643732
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SCYL2: view

Phenotypes for SCYL2 Gene

GenomeRNAi human phenotypes for SCYL2:
genes like me logo Genes that share phenotypes with SCYL2: view

miRNA for SCYL2 Gene

miRTarBase miRNAs that target SCYL2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCYL2 Gene

Localization for SCYL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCYL2 Gene

Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Note=According to PubMed:15809293, plasma membrane-associated in clathrin-coated vesicles. According to PubMed:16914521, colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCYL2 Gene COMPARTMENTS Subcellular localization image for SCYL2 gene
Compartment Confidence
endosome 5
golgi apparatus 3
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SCYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005794 Golgi apparatus IEA --
GO:0010008 endosome membrane IEA --
GO:0016020 membrane --
GO:0030136 clathrin-coated vesicle IEA --
genes like me logo Genes that share ontologies with SCYL2: view

Pathways for SCYL2 Gene

SuperPathways for SCYL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization IDA 19643732
GO:0006468 protein phosphorylation IEA --
GO:0008333 endosome to lysosome transport IDA 19643732
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 19643732
GO:2000286 receptor internalization involved in canonical Wnt signaling pathway IDA 19643732
genes like me logo Genes that share ontologies with SCYL2: view

No data available for Pathways by source for SCYL2 Gene

Transcripts for SCYL2 Gene

Unigene Clusters for SCYL2 Gene

SCY1-like 2 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCYL2 Gene

No ASD Table

Relevant External Links for SCYL2 Gene

GeneLoc Exon Structure for
SCYL2
ECgene alternative splicing isoforms for
SCYL2

Expression for SCYL2 Gene

mRNA expression in normal human tissues for SCYL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCYL2 Gene

SOURCE GeneReport for Unigene cluster for SCYL2 Gene Hs.506481

genes like me logo Genes that share expressions with SCYL2: view

Orthologs for SCYL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SCYL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCYL2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCYL2 36
  • 94.44 (n)
  • 96.99 (a)
SCYL2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCYL2 36
  • 93.9 (n)
  • 97.09 (a)
SCYL2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scyl2 36
  • 88.81 (n)
  • 93.11 (a)
Scyl2 16
Scyl2 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCYL2 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCYL2 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scyl2 36
  • 89.34 (n)
  • 94.08 (a)
chicken
(Gallus gallus)
Aves SCYL2 36
  • 79.84 (n)
  • 83.82 (a)
SCYL2 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCYL2 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scyl2 36
  • 74.21 (n)
  • 78.57 (a)
zebrafish
(Danio rerio)
Actinopterygii SCYL2 37
  • 71 (a)
OneToOne
si:ch211-244b2.1 36
  • 66.74 (n)
  • 74.05 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002142 36
  • 49.49 (n)
  • 44.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1951 36
  • 54.57 (n)
  • 51.72 (a)
CG1951 37
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZC581.9 37
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCY1 37
  • 23 (a)
OneToOne
SCY1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 57 (a)
OneToOne
Species with no ortholog for SCYL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCYL2 Gene

ENSEMBL:
Gene Tree for SCYL2 (if available)
TreeFam:
Gene Tree for SCYL2 (if available)

Paralogs for SCYL2 Gene

Pseudogenes.org Pseudogenes for SCYL2 Gene

genes like me logo Genes that share paralogs with SCYL2: view

No data available for Paralogs for SCYL2 Gene

Variants for SCYL2 Gene

Sequence variations from dbSNP and Humsavar for SCYL2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs828928 -- 100,274,253(-) attat(C/T)ggata intron-variant
rs828930 -- 100,293,625(-) GTTTA(G/T)CTGCT intron-variant
rs828931 -- 100,323,045(-) Atttt(C/T)ttttt intron-variant
rs828932 -- 100,323,030(-) ttttt(C/T)ttgag intron-variant
rs864889 -- 100,293,130(-) attaa(A/G)aaaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCYL2 Gene

Variant ID Type Subtype PubMed ID
esv2518688 CNV Deletion 19546169
esv2364259 CNV Deletion 18987734
esv2746277 CNV Deletion 23290073
esv2672785 CNV Deletion 23128226

Relevant External Links for SCYL2 Gene

HapMap Linkage Disequilibrium report
SCYL2

Disorders for SCYL2 Gene

No disorders were found for SCYL2 Gene.

No data available for UniProtKB/Swiss-Prot for SCYL2 Gene

Publications for SCYL2 Gene

  1. Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network. (PMID: 16914521) Duewel M. … Ungewickell E.J. (Mol. Biol. Cell 2006) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. (PMID: 15809293) Conner S.D. … Schmid S.L. (J. Biol. Chem. 2005) 3 4

Products for SCYL2 Gene

  • Addgene plasmids for SCYL2

Sources for SCYL2 Gene

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