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SCYL2 Gene

protein-coding   GIFtS: 53
GCID: GC12P100661

SCY1-Like 2 (S. Cerevisiae)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SCY1-Like 2 (S. Cerevisiae)1 2
Coated Vesicle-Associated Kinase Of 104 KDa2 3
CVAK1042 3
SCY1-Like Protein 22
KIAA13603

External Ids:    HGNC: 192861   Entrez Gene: 556812   Ensembl: ENSG000001360217   UniProtKB: Q6P3W73   

Export aliases for SCYL2 gene to outside databases

Previous GC identifers: GC12P099164 GC12P097722


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SCYL2 Gene:
SCYL2 (SCY1-like 2 (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include protein kinase activity and receptor binding.

UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7
Function: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated
vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro,
the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine.
According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent
trafficking between the TGN and/or the endosomal system

Gene Wiki entry for SCYL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCYL2 gene promoter:
         TBP   Pax-2   Nkx2-5   STAT5A   IRF-1   Pax-2a   Pax-2b   Zic3   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCYL2 promoter sequence
   Search Chromatin IP Primers for SCYL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCYL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1   Ensembl cytogenetic band:  12q23.1   HGNC cytogenetic band: 12q23.1

SCYL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCYL2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P100661:  view genomic region     (about GC identifiers)

Start:
100,660,918 bp from pter      End:
100,735,502 bp from pter
Size:
74,585 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7 (See protein sequence)
Recommended Name: SCY1-like protein 2  
Size: 929 amino acids; 103709 Da
Subunit: Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex
Sequence caution: Sequence=BAA91778.1; Type=Erroneous initiation; Sequence=BAB14869.1; Type=Erroneous initiation;
Sequence=BAB55194.1; Type=Erroneous initiation;
Secondary accessions: A8KAB5 Q96EF4 Q96ST4 Q9H7V5 Q9NVH3 Q9P2I7

Explore the universe of human proteins at neXtProt for SCYL2: NX_Q6P3W7

Explore proteomics data for SCYL2 at MOPED

Post-translational modifications: 

  • According to PubMed:15809293, autophosphorylated in presence of poly-L-lysine1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SCYL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060458.3  
    ENSEMBL proteins: 
     ENSP00000448366   ENSP00000450294   ENSP00000354061   ENSP00000449567   ENSP00000448400  

    SCYL2 Human Recombinant Protein Products:

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    Novus Biologicals SCYL2 Proteins
    Novus Biologicals SCYL2 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCYL2

     
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    antibodies-online proteins for SCYL2 (4 products) 

     
    antibodies-online peptides for SCYL2

    SCYL2 Antibody Products:

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    antibodies-online antibodies for SCYL2 (24 products) 

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    Cloud-Clone Corp. ELISAs for SCYL2
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    Search eBioscience for ELISAs for SCYL2 
    antibodies-online kits for SCYL2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: SCY1-like 2 (S. cerevisiae)
    SCY1 family

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6P3W7

    ProtoNet protein and cluster: Q6P3W7

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 1 HEAT repeat
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with SCYL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCYL2_HUMAN, Q6P3W7
    Function: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated
    vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro,
    the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine.
    According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent
    trafficking between the TGN and/or the endosomal system

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0005102receptor binding IPI19643732
    GO:0005488binding ----
    GO:0005515protein binding IPI19643732
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with SCYL2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SCYL2:
     Increased number of small and   Proliferating cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SCYL2

    miRNA
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    miRTarBase miRNAs that target SCYL2:
    hsa-mir-92a-3p (MIRT049398)

    Block miRNA regulation of human, mouse, rat SCYL2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate SCYL2:
    hsa-miR-323-3p hsa-miR-1304 hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-561 hsa-miR-524-5p hsa-miR-1827 hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidSCYL2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SCYL2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SCYL2 (NM_017988)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL2
    Addgene plasmids for SCYL2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCYL2_HUMAN, Q6P3W7: Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi
    apparatus, trans-Golgi network membrane. Endosome membrane. Note=According to PubMed:15809293, plasma
    membrane-associated in clathrin-coated vesicles. According to PubMed:16914521, colocalizes to the trans-Golgi
    network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3
    complexes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus3
    cytosol2
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0010008endosome membrane IEA--
    GO:0030136clathrin-coated vesicle IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with SCYL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCYL2
    Interactions:

        Search GeneGlobe Interaction Network for SCYL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SCYL2 (Q6P3W72, 3 ENSP000003540614) via UniProtKB, MINT, STRING, and/or I2D (see all 786)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCT6AP402272, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ZFYVE9O954052, 3MINT-62055 I2D: score=3 
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    ARRB1P494073, ENSP000003771414I2D: score=1 STRING: ENSP00000377141
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002092positive regulation of receptor internalization IDA19643732
    GO:0006468protein phosphorylation ----
    GO:0008333endosome to lysosome transport IDA19643732
    GO:0090090negative regulation of canonical Wnt signaling pathway IDA19643732
    GO:2000286receptor internalization involved in canonical Wnt signaling pathway IDA19643732

    Find genes that share ontologies with SCYL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCYL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCYL2 gene: 
    NM_017988.4  

    Unigene Cluster for SCYL2:

    SCY1-like 2 (S. cerevisiae)
    Hs.506481  [show with all ESTs]
    Unigene Representative Sequence: AB037781
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000549687(uc009ztw.1 uc001thm.1) ENST00000548392 ENST00000550067
    ENST00000360820(uc001thn.3) ENST00000549486 ENST00000550251 ENST00000553148
    ENST00000548871 ENST00000547202 ENST00000547735
    miRNA
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    Block miRNA regulation of human, mouse, rat SCYL2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate SCYL2:
    hsa-miR-323-3p hsa-miR-1304 hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-561 hsa-miR-524-5p hsa-miR-1827 hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidSCYL2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat SCYL2

    Additional mRNA sequence: 

    AB037781.1 AK000936.1 AK001597.1 AK024274.1 AK026160.1 AK027551.1 AK125091.1 AK292980.1 
    AL133044.1 BC011525.1 BC012387.2 BC063798.1 

    16 DOTS entries:

    DT.113777  DT.99975660  DT.92017103  DT.121127782  DT.92024438  DT.91989189  DT.99989935  DT.121127753 
    DT.40252890  DT.91767850  DT.95274467  DT.121127752  DT.121127758  DT.99980806  DT.99980828  DT.91767854 

    Selected AceView cDNA sequences (see all 170):

    AA496898 BG284823 BC011525 BM766851 AA280659 AA689328 BC063798 BM837173 
    AK001597 BM768998 CB122856 BM905696 CB129787 AA496859 C00727 AI366877 
    AI911584 BQ015311 AW613144 AU117593 AL598327 AA504708 AI648671 BU618611 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCYL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAAAAAG
    SCYL2 Expression
    About this image


    SCYL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SCYL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCYL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506481
        Custom PCR Arrays for SCYL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SCYL2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scyl21 , 5 SCY1-like 2 (S. cerevisiae)1, 5 88.81(n)1
    93.11(a)1
      10 (45.05 cM)5
    2133261  NM_198021.21  NP_932138.11 
     896387215 
    chicken
    (Gallus gallus)
    Aves SCYL21 SCY1-like 2 (S. cerevisiae) 79.84(n)
    83.82(a)
      417930  NM_001030751.1  NP_001025922.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCYL26
    SCY1-like 2 (S. cerevisiae)
    83(a)
    1 ↔ 1
    5(28679670-28710973)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia scyl21 SCY1-like 2 (S. cerevisiae) 74.21(n)
    78.57(a)
      100486630  XM_002936831.2  XP_002936877.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-244b2.11 si:ch211-244b2.1 66.74(n)
    74.05(a)
      557149  NM_001080799.1  NP_001074268.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG19511 CG1951 54.57(n)
    51.72(a)
      43423  NM_143398.3  NP_651655.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZC581.96
    Protein ZC581.9 (ZC581.9) mRNA, complete cds
    21(a)
    1 ↔ 1
    I(6665120-6670409) WBGene00022635
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCY1(YGL083W)4 Putative kinase, suppressor of GTPase mutant, similar more   --   7(353058-355472) 852797  NP_011432.1 


    ENSEMBL Gene Tree for SCYL2 (if available)
    TreeFam Gene Tree for SCYL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCYL2 gene

    Find genes that share paralogs with SCYL2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SCYL2
    PGOHUM00000261348


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCYL2 (see all 1315)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413704
    A lung adenocarcinoma sample4--see VAR_0413702 Q H mis40--------
    rs1462844011,2
    --100662864(+) AATGCA/CGACCT 1 -- int10--------
    rs1813699661,2
    --100663043(+) TGTTCC/TCCTGC 1 -- int10--------
    rs1859487871,2
    --100663075(+) ATGCTA/CCTTCC 1 -- int10--------
    rs2005969861,2
    --100663105(+) CTTTC-/TTTTTT 1 -- int10--------
    rs751866111,2
    C,F--100663137(+) TCATTC/TAGCTC 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1921487541,2
    --100663248(+) ATTAGA/TTGTTC 1 -- int10--------
    rs1837849341,2
    --100663323(+) AATGGA/GCCAAG 1 -- int10--------
    rs1892482441,2
    --100663365(+) TGTTAA/GTCCTT 1 -- int10--------
    rs1907478581,2
    --100663555(+) TTCATC/TAGAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SCYL2 (100660918 - 100735502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SCYL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746277CNV Deletion23290073
    esv2672785CNV Deletion23128226
    esv2518688CNV Deletion19546169
    esv2364259CNV Deletion18987734

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCYL2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with SCYL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network. (PubMed id 16914521)1, 2, 9 Duewel M. and Ungewickell E.J. (Mol. Biol. Cell 2006)
    3. Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. (PubMed id 16903783)1, 2 Schmid E.M.... McMahon H.T. (PLoS Biol. 2006)
    4. CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. (PubMed id 15809293)1, 2 Conner S.D. and Schmid S.L. (J. Biol. Chem. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese. (PubMed id 23341777)1 Dong J....Shen H. (PLoS Genet. 2013)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    9. Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu. (PubMed id 23047923)1 Miyakawa K....Ryo A. (Sci Signal 2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55681 HGNC: 19286 AceView: FLJ10074 Ensembl:ENSG00000136021 euGenes: HUgn55681
    ECgene: SCYL2 H-InvDB: SCYL2

    (According to HUGE)
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    HUGE: KIAA1360

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCYL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCYL2 gene:
    Search GeneIP for patents involving SCYL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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