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SCYL2 Gene

protein-coding GIFtS: 53
GCID: GC12P100661

SCY1-Like 2 (S. Cerevisiae)

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MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
SCY1-Like 2 (S. Cerevisiae)¹ ²
Coated Vesicle-Associated Kinase Of 104 KDa² ³
CVAK104² ³
SCY1-Like Protein 2²
KIAA1360³

External Ids:	HGNC: 19286¹	Entrez Gene: 55681²	Ensembl: ENSG00000136021⁷	UniProtKB: Q6P3W7³

Export aliases for SCYL2 gene to outside databases

Previous GC identifers: GC12P099164 GC12P097722

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SCYL2 Gene:

SCYL2 (SCY1-like 2 (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include protein kinase activity and receptor binding.

UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7

Function: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated

vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro,

the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine.

According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent

trafficking between the TGN and/or the endosomal system

Gene Wiki entry for SCYL2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000012.11 NT_029419.13 NC_018923.2

Regulatory elements:

Regulatory transcription factor binding sites in the SCYL2 gene promoter:
TBP Pax-2 Nkx2-5 STAT5A IRF-1 Pax-2a Pax-2b Zic3 Pax-4a ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCYL2 promoter sequence

Search Chromatin IP Primers for SCYL2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCYL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1 Ensembl cytogenetic band: 12q23.1 HGNC cytogenetic band: 12q23.1

SCYL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCYL2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P100661: view genomic region (about GC identifiers)

Start:	100,660,918 bp from pter	End:	100,735,502 bp from pter
Size:	74,585 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7 (See protein sequence)

Recommended Name: SCY1-like protein 2

Size: 929 amino acids; 103709 Da

Subunit: Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex

Sequence caution: Sequence=BAA91778.1; Type=Erroneous initiation; Sequence=BAB14869.1; Type=Erroneous initiation;

Sequence=BAB55194.1; Type=Erroneous initiation;

Secondary accessions: A8KAB5 Q96EF4 Q96ST4 Q9H7V5 Q9NVH3 Q9P2I7

Explore the universe of human proteins at neXtProt for SCYL2: NX_Q6P3W7

Explore proteomics data for SCYL2 at MOPED

Post-translational modifications:

According to PubMed:15809293, autophosphorylated in presence of poly-L-lysine¹

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See SCYL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060458.3

ENSEMBL proteins:

ENSP00000448366 ENSP00000450294 ENSP00000354061 ENSP00000449567 ENSP00000448400

SCYL2 Human Recombinant Protein Products:

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	antibodies-online proteins for SCYL2 (4 products)
	antibodies-online peptides for SCYL2

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	antibodies-online kits for SCYL2 (4 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

IUPHAR Guide to PHARMACOLOGY protein family classification: SCY1-like 2 (S. cerevisiae)

SCY1 family

4 InterPro protein domains:

IPR011989 ARM-like

IPR011009 Kinase-like_dom

IPR000719 Prot_kinase_dom

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q6P3W7

ProtoNet protein and cluster: Q6P3W7

1 Blocks protein domain: IPB000357 HEAT repeat

UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7

Similarity: Belongs to the protein kinase superfamily

Similarity: Contains 1 HEAT repeat

Similarity: Contains 1 protein kinase domain

Find genes that share domains with SCYL2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SCYL2_HUMAN, Q6P3W7

Function: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated

vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro,

the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine.

According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent

trafficking between the TGN and/or the endosomal system

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	IEA	--
GO:0005102	receptor binding	IPI	19643732
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	19643732
GO:0005524	ATP binding	IEA	--

Find genes that share ontologies with SCYL2 About GenesLikeMe

Phenotypes:
2 GenomeRNAi human phenotypes for SCYL2:

Increased number of small and

Proliferating cells

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for SCYL2

miRNA Products:		miRTarBase miRNAs that target SCYL2: hsa-mir-92a-3p (MIRT049398)

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		8 qRT-PCR Assays for microRNAs that regulate SCYL2:
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

SCYL2_HUMAN, Q6P3W7: Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi

apparatus, trans-Golgi network membrane. Endosome membrane. Note=According to PubMed:15809293, plasma

membrane-associated in clathrin-coated vesicles. According to PubMed:16914521, colocalizes to the trans-Golgi

network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3

complexes

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endosome	5
golgi apparatus	3
cytosol	2
extracellular	1
mitochondrion	1
nucleus	1
peroxisome	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	IEA	--
GO:0010008	endosome membrane	IEA	--
GO:0030136	clathrin-coated vesicle	IEA	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

Find genes that share ontologies with SCYL2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for SCYL2
Interactions:

Search GeneGlobe Interaction Network for SCYL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for SCYL2 (Q6P3W7^{2, 3} ENSP00000354061⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 786)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCT6A	P40227²^,³	MINT-7945693 MINT-7947479 I2D: score=1
ZFYVE9	O95405²^,³	MINT-62055 I2D: score=3
CDC5L	Q99459², ENSP00000360532⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000360532
SNW1	Q13573², ENSP00000261531⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000261531
ARRB1	P49407³, ENSP00000377141⁴	I2D: score=1 STRING: ENSP00000377141

About this table

Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002092	positive regulation of receptor internalization	IDA	19643732
GO:0006468	protein phosphorylation	--	--
GO:0008333	endosome to lysosome transport	IDA	19643732
GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	19643732
GO:2000286	receptor internalization involved in canonical Wnt signaling pathway	IDA	19643732

Find genes that share ontologies with SCYL2 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

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Browse compounds at ApexBio

Browse Tocris compounds for SCYL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for SCYL2 gene (3 alternative transcripts):

NM_017988.4 XM_005269018.1 XM_006719497.1

Unigene Cluster for SCYL2:

SCY1-like 2 (S. cerevisiae)

Hs.506481 [show with all ESTs]

Unigene Representative Sequence: AB037781

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000549687(uc009ztw.1 uc001thm.1) ENST00000548392 ENST00000550067

ENST00000360820(uc001thn.3) ENST00000549486 ENST00000550251 ENST00000553148

ENST00000548871 ENST00000547202 ENST00000547735

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		8 qRT-PCR Assays for microRNAs that regulate SCYL2:
		hsa-miR-323-3p hsa-miR-1304 hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-561 hsa-miR-524-5p hsa-miR-1827 hsa-miR-34a*

		SwitchGear 3'UTR luciferase reporter plasmid: SCYL2 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: SCYL2 (NM_017988)
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		QuantiFast Probe-based Assays in human, mouse, rat SCYL2

Additional mRNA sequence:

AB037781.1 AK000936.1 AK001597.1 AK024274.1 AK026160.1 AK027551.1 AK125091.1 AK292980.1

AL133044.1 BC011525.1 BC012387.2 BC063798.1

16 DOTS entries:

DT.113777 DT.99975660 DT.92017103 DT.121127782 DT.92024438 DT.91989189 DT.99989935 DT.121127753

DT.40252890 DT.91767850 DT.95274467 DT.121127752 DT.121127758 DT.99980806 DT.99980828 DT.91767854

Selected AceView cDNA sequences (see all 170):

AA496898 BG284823 BC011525 BM766851 AA280659 AA689328 BC063798 BM837173

AK001597 BM768998 CB122856 BM905696 CB129787 AA496859 C00727 AI366877

AI911584 BQ015311 AW613144 AU117593 AL598327 AA504708 AI648671 BU618611

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCYL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAAGAAAAAG

About this image

SCYL2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 6) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Ovary (Reproductive System)
Oviduct

Pancreas (Endocrine System)
Islets of Langerhans

Testis (Reproductive System)
Leydig Cells Testis Interstitium

SCYL2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SCYL2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.506481

Custom PCR Arrays for SCYL2

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for SCYL2 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Scyl2^{1 , 5}	SCY1-like 2 (S. cerevisiae)^{1, 5}	88.81(n)¹ 93.11(a)¹		10 (45.05 cM)⁵ 213326¹ NM_198021.2¹ NP_932138.1¹ 89638721⁵
chicken (Gallus gallus)	Aves	SCYL2¹	SCY1-like 2 (S. cerevisiae)	79.84(n) 83.82(a)		417930 NM_001030751.1 NP_001025922.1
lizard (Anolis carolinensis)	Reptilia	SCYL2⁶	SCY1-like 2 (S. cerevisiae)	83(a)	1 ↔ 1	5(28679670-28710973)
tropical clawed frog (Xenopus tropicalis)	Amphibia	scyl2¹	SCY1-like 2 (S. cerevisiae)	74.21(n) 78.57(a)		100486630 XM_002936831.2 XP_002936877.2
zebrafish (Danio rerio)	Actinopterygii	si:ch211-244b2.1¹	si:ch211-244b2.1	66.74(n) 74.05(a)		557149 NM_001080799.1 NP_001074268.1
fruit fly (Drosophila melanogaster)	Insecta	CG1951¹	CG1951	54.57(n) 51.72(a)		43423 NM_143398.3 NP_651655.1
worm (Caenorhabditis elegans)	Secernentea	ZC581.9⁶	Protein ZC581.9 (ZC581.9) mRNA, complete cds	21(a)	1 ↔ 1	I(6665120-6670409) WBGene00022635
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SCY1(YGL083W)⁴	Putative kinase, suppressor of GTPase mutant, similar more	--		7(353058-355472) 852797 NP_011432.1

ENSEMBL Gene Tree for SCYL2 (if available)
TreeFam Gene Tree for SCYL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for SCYL2 gene

Find genes that share paralogs with SCYL2 About GenesLikeMe

1 Pseudogenes.org Pseudogene for SCYL2
PGOHUM00000261348

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_041370⁴		A lung adenocarcinoma sample⁴	--	see VAR_041370	2	Q H	mis⁴		0	--	--	--	--
rs146284401^1,2		--	100662864(+)	`AATGCA/CGACCT`	1	--	int¹		0	--	--	--	--
rs181369966^1,2		--	100663043(+)	`TGTTCC/TCCTGC`	1	--	int¹		0	--	--	--	--
rs185948787^1,2		--	100663075(+)	`ATGCTA/CCTTCC`	1	--	int¹		0	--	--	--	--
rs200596986^1,2		--	100663105(+)	`CTTTC-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs75186611^1,2	C,F	--	100663137(+)	`TCATTC/TAGCTC`	1	--	int¹		1		EA	120
rs192148754^1,2		--	100663248(+)	`ATTAGA/TTGTTC`	1	--	int¹		0	--	--	--	--
rs183784934^1,2		--	100663323(+)	`AATGGA/GCCAAG`	1	--	int¹		0	--	--	--	--
rs189248244^1,2		--	100663365(+)	`TGTTAA/GTCCTT`	1	--	int¹		0	--	--	--	--
rs190747858^1,2		--	100663555(+)	`TTCATC/TAGAAT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SCYL2 (100660918 - 100735502 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for SCYL2: About this table

Variant ID	Type	Subtype	PubMed ID
esv2746277	CNV	Deletion	23290073
esv2672785	CNV	Deletion	23128226
esv2518688	CNV	Deletion	19546169
esv2364259	CNV	Deletion	18987734

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SCYL2

DNA2.0 Custom Variant and Variant Library Synthesis for SCYL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SCYL2 gene, integrated from 10 sources (see all 25):
(articles sorted by number of sources associating them with SCYL2)

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2, 3} Nagase T.... Ohara O. (DNA Res. 2000)
Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network. (PubMed id 16914521)^{1, 2, 9} Duewel M. and Ungewickell E.J. (Mol. Biol. Cell 2006)
Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. (PubMed id 16903783)^{1, 2} Schmid E.M.... McMahon H.T. (PLoS Biol. 2006)
CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. (PubMed id 15809293)^{1, 2} Conner S.D. and Schmid S.L. (J. Biol. Chem. 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese. (PubMed id 23341777)¹ Dong J....Shen H. (PLoS Genet. 2013)
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)¹ Cox J.L....Rizzino A. (PLoS ONE 2013)
Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu. (PubMed id 23047923)¹ Miyakawa K....Ryo A. (Sci Signal 2012)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55681	HGNC: 19286	AceView: FLJ10074	Ensembl:ENSG00000136021	euGenes: HUgn55681
ECgene: SCYL2	H-InvDB: SCYL2

(According to HUGE)
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HUGE: KIAA1360

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SCYL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SCYL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SCYL2 gene:
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SCY1-Like 2 (S. Cerevisiae)

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SCYL2 Gene

SCY1-Like 2 (S. Cerevisiae)

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