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Aliases for SCYL2 Gene

Aliases for SCYL2 Gene

  • SCY1 Like Pseudokinase 2 2 3 5
  • Coated Vesicle-Associated Kinase Of 104 KDa 2 3 4
  • SCY1-Like, Kinase-Like 2 2 3
  • CVAK104 3 4
  • SCY1-Like 2 (S. Cerevisiae) 2
  • SCY1-Like Protein 2 3
  • SCY1-Like 2 3
  • KIAA1360 4

External Ids for SCYL2 Gene

Previous GeneCards Identifiers for SCYL2 Gene

  • GC12P099164
  • GC12P100661
  • GC12P097722

Summaries for SCYL2 Gene

Entrez Gene Summary for SCYL2 Gene

  • The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for SCYL2 Gene

SCYL2 (SCY1 Like Pseudokinase 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and binding. An important paralog of this gene is SCYL1.

UniProtKB/Swiss-Prot for SCYL2 Gene

  • Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system.

Gene Wiki entry for SCYL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCYL2 Gene

Genomics for SCYL2 Gene

Regulatory Elements for SCYL2 Gene

Enhancers for SCYL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F100185 0.4 Ensembl 10.8 -81.5 -81537 0.8 SMARCA4 POLR2A SMAD4 ZNF644 HOMEZ SPI1 RARA UHRF1BP1L DEPDC4 SCYL2 MIR1827 PIR35895
GH12F100266 0.2 ENCODE 5.8 +0.8 838 3.6 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ACTR6 ENSG00000257325 ENSG00000257489 SCYL2 RN7SL176P DEPDC4 GC12M100306
GH12F100279 0.5 Ensembl ENCODE 4.5 +12.7 12740 1.4 HLF PBX2 HMBOX1 ZBTB33 SLC17A8 ACTR6 SCYL2 DEPDC4 GC12M100306
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SCYL2 on UCSC Golden Path with GeneCards custom track

Promoters for SCYL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000435690 464 2800 HDGF PKNOX1 ATF1 WRNIP1 ZFP64 ARID4B SIN3A ZNF48 BRCA1 ZNF2

Genomic Location for SCYL2 Gene

Chromosome:
12
Start:
100,267,137 bp from pter
End:
100,341,724 bp from pter
Size:
74,588 bases
Orientation:
Plus strand

Genomic View for SCYL2 Gene

Genes around SCYL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCYL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCYL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCYL2 Gene

Proteins for SCYL2 Gene

  • Protein details for SCYL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3W7-SCYL2_HUMAN
    Recommended name:
    SCY1-like protein 2
    Protein Accession:
    Q6P3W7
    Secondary Accessions:
    • A8KAB5
    • Q96EF4
    • Q96ST4
    • Q9H7V5
    • Q9NVH3
    • Q9P2I7

    Protein attributes for SCYL2 Gene

    Size:
    929 amino acids
    Molecular mass:
    103709 Da
    Quaternary structure:
    • Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex.
    SequenceCaution:
    • Sequence=BAA91778.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14869.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55194.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SCYL2 Gene

Post-translational modifications for SCYL2 Gene

  • According to PubMed:15809293, autophosphorylated in presence of poly-L-lysine.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCYL2 Gene

Domains & Families for SCYL2 Gene

Gene Families for SCYL2 Gene

Protein Domains for SCYL2 Gene

Suggested Antigen Peptide Sequences for SCYL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P3W7

UniProtKB/Swiss-Prot:

SCYL2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily.
  • Contains 1 HEAT repeat.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily.
Similarity:
  • Contains 1 HEAT repeat.
genes like me logo Genes that share domains with SCYL2: view

Function for SCYL2 Gene

Molecular function for SCYL2 Gene

UniProtKB/Swiss-Prot Function:
Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system.

Gene Ontology (GO) - Molecular Function for SCYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005102 receptor binding IPI 19643732
GO:0005515 protein binding IPI 19643732
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SCYL2: view
genes like me logo Genes that share phenotypes with SCYL2: view

Animal Models for SCYL2 Gene

MGI Knock Outs for SCYL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SCYL2

miRNA for SCYL2 Gene

miRTarBase miRNAs that target SCYL2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SCYL2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCYL2 Gene

Localization for SCYL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCYL2 Gene

Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Note=According to PubMed:15809293, plasma membrane-associated in clathrin-coated vesicles. According to PubMed:16914521, colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCYL2 Gene COMPARTMENTS Subcellular localization image for SCYL2 gene
Compartment Confidence
endosome 5
golgi apparatus 5
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SCYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IEA --
GO:0010008 endosome membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SCYL2: view

Pathways & Interactions for SCYL2 Gene

SuperPathways for SCYL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization IDA 19643732
GO:0006468 protein phosphorylation IEA --
GO:0008333 endosome to lysosome transport IDA 19643732
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 19643732
GO:2000286 receptor internalization involved in canonical Wnt signaling pathway IDA 19643732
genes like me logo Genes that share ontologies with SCYL2: view

No data available for Pathways by source and SIGNOR curated interactions for SCYL2 Gene

Transcripts for SCYL2 Gene

Unigene Clusters for SCYL2 Gene

SCY1-like 2 (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SCYL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCYL2 Gene

No ASD Table

Relevant External Links for SCYL2 Gene

GeneLoc Exon Structure for
SCYL2
ECgene alternative splicing isoforms for
SCYL2

Expression for SCYL2 Gene

mRNA expression in normal human tissues for SCYL2 Gene

Protein differential expression in normal tissues from HIPED for SCYL2 Gene

This gene is overexpressed in Platelet (6.7) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCYL2 Gene



Protein tissue co-expression partners for SCYL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCYL2 Gene:

SCYL2

SOURCE GeneReport for Unigene cluster for SCYL2 Gene:

Hs.506481
genes like me logo Genes that share expression patterns with SCYL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCYL2 Gene

Orthologs for SCYL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SCYL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCYL2 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCYL2 34 35
  • 94.44 (n)
dog
(Canis familiaris)
Mammalia SCYL2 34 35
  • 93.9 (n)
oppossum
(Monodelphis domestica)
Mammalia SCYL2 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCYL2 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scyl2 34
  • 89.34 (n)
mouse
(Mus musculus)
Mammalia Scyl2 34 16 35
  • 88.81 (n)
chicken
(Gallus gallus)
Aves SCYL2 34 35
  • 79.84 (n)
lizard
(Anolis carolinensis)
Reptilia SCYL2 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scyl2 34
  • 74.21 (n)
zebrafish
(Danio rerio)
Actinopterygii SCYL2 35
  • 71 (a)
OneToOne
si:ch211-244b2.1 34
  • 66.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1951 34 35
  • 54.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002142 34
  • 49.49 (n)
worm
(Caenorhabditis elegans)
Secernentea ZC581.9 35
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCY1 35 37
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
OneToOne
Species where no ortholog for SCYL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCYL2 Gene

ENSEMBL:
Gene Tree for SCYL2 (if available)
TreeFam:
Gene Tree for SCYL2 (if available)

Paralogs for SCYL2 Gene

Paralogs for SCYL2 Gene

Pseudogenes.org Pseudogenes for SCYL2 Gene

genes like me logo Genes that share paralogs with SCYL2: view

Variants for SCYL2 Gene

Sequence variations from dbSNP and Humsavar for SCYL2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_041370 A lung adenocarcinoma sample
rs10161023 -- 100,301,502(+) AACTT(A/G)ATGTG intron-variant
rs10161355 -- 100,309,133(+) gtgtg(C/T)gcgcg intron-variant
rs10644195 -- 100,320,549(+) CTCAA(-/AAAT)AAATA intron-variant
rs10778049 -- 100,318,165(+) GCATT(A/T)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCYL2 Gene

Variant ID Type Subtype PubMed ID
esv2364259 CNV deletion 18987734
esv2518688 CNV deletion 19546169
esv2672785 CNV deletion 23128226
esv2746277 CNV deletion 23290073
esv3549674 CNV deletion 23714750
esv3580426 CNV loss 25503493
nsv1070124 CNV deletion 25765185
nsv559964 CNV gain 21841781
nsv958649 CNV deletion 24416366
nsv977143 CNV duplication 23825009

Variation tolerance for SCYL2 Gene

Residual Variation Intolerance Score: 7.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCYL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCYL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCYL2 Gene

Disorders for SCYL2 Gene

Relevant External Links for SCYL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCYL2

No disorders were found for SCYL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCYL2 Gene

Publications for SCYL2 Gene

  1. Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network. (PMID: 16914521) Duewel M. … Ungewickell E.J. (Mol. Biol. Cell 2006) 3 4 22 64
  2. CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. (PMID: 15809293) Conner S.D. … Schmid S.L. (J. Biol. Chem. 2005) 2 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  4. CVAK104 is a novel regulator of clathrin-mediated SNARE sorting. (PMID: 17587408) Borner G.H. … Robinson M.S. (Traffic 2007) 2 3 64
  5. Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. (PMID: 16903783) Schmid E.M. … McMahon H.T. (PLoS Biol. 2006) 3 4 64

Products for SCYL2 Gene

Sources for SCYL2 Gene

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