Aliases for SCYL2 Gene
Aliases for SCYL2 Gene
External Ids for SCYL2 Gene
- HGNC: 19286
- Entrez Gene: 55681
- Ensembl: ENSG00000136021
- OMIM: 616365
- UniProtKB: Q6P3W7
Previous GeneCards Identifiers for SCYL2 Gene
- GC12P099164
- GC12P100661
- GC12P097722
Summaries for SCYL2 Gene
-
The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
GeneCards Summary for SCYL2 Gene
SCYL2 (SCY1 Like Pseudokinase 2) is a Protein Coding gene. Diseases associated with SCYL2 include Cataract 8, Multiple Types. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and binding.
UniProtKB/Swiss-Prot for SCYL2 Gene
-
Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCYL2 Gene
Genomics for SCYL2 Gene
GeneHancer (GH) Regulatory Elements for SCYL2 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12I100266 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 564.3 | +0.8 | 838 | 3.6 | HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 | SCYL2 DEPDC4 ACTR6 RN7SL176P GC12M100395 | |
GH12I100277 | Promoter | 0.5 | EPDnew | 550.4 | +10.8 | 10831 | 0.1 | SCYL2 SLC17A8 ACTR6 DEPDC4 GC12M100395 | ||
GH12I100198 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 23.2 | -66.0 | -66018 | 4.4 | HDGF SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B E2F8 | ACTR6 ENSG00000257489 SCYL2 GOLGA2P5 ANKS1B GC12M100397 | |
GH12I100500 | Promoter/Enhancer | 1.4 | EPDnew ENCODE dbSUPER | 11.9 | +236.4 | 236448 | 5.7 | FOXA2 RXRA TAF1 MAX REST RAD21 FOXA1 GABPA YY1 JUND | NR1H4 UTP20 SCYL2 ENSG00000271177 | |
GH12I100228 | Enhancer | 0.7 | ENCODE | 11.8 | -36.7 | -36681 | 3.1 | MEIS2 CTCF PKNOX1 DDX20 ZSCAN4 NEUROD1 CEBPG ZBTB40 RAD21 CC2D1A | SCYL2 ACTR6 ANKS1B GC12P100217 GC12M100398 DEPDC4 |
Regulatory Element Products
Genomic Locations for SCYL2 Gene
- chr12:100,267,137-100,341,724
- (GRCh38/hg38)
- Size:
- 74,588 bases
- Orientation:
- Plus strand
- chr12:100,660,918-100,735,502
- (GRCh37/hg19)
Genomic View for SCYL2 Gene
- Cytogenetic band:
-
- 12q23.1 by Ensembl
- 12q23.1 by Entrez Gene
- 12q23.1 by HGNC


RefSeq DNA sequence for SCYL2 Gene
Proteins for SCYL2 Gene
-
Protein details for SCYL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6P3W7-SCYL2_HUMAN
- Recommended name:
- SCY1-like protein 2
- Protein Accession:
- Q6P3W7
- A8KAB5
- Q96EF4
- Q96ST4
- Q9H7V5
- Q9NVH3
- Q9P2I7
Protein attributes for SCYL2 Gene
- Size:
- 929 amino acids
- Molecular mass:
- 103709 Da
- Quaternary structure:
-
- Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex.
- SequenceCaution:
-
- Sequence=BAA91778.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14869.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55194.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SCYL2 Gene
Post-translational modifications for SCYL2 Gene
- According to PubMed:15809293, autophosphorylated in presence of poly-L-lysine.
Other Protein References for SCYL2 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SCYL2
- Novus Biologicals Antibodies for SCYL2
-
Abcam antibodies for SCYL2
- Invitrogen Antibodies for SCYL2
- Search GeneTex for Antibodies for SCYL2
Protein Products
-
OriGene Purified Proteins for SCYL2
- Search Origene for MassSpec and Protein Over-expression Lysates for SCYL2
- Origene Custom Protein Services for SCYL2
- Search GeneTex for Proteins for SCYL2
-
Abcam proteins for SCYL2
Assay Products
- antibodies-online: Search results for 1 available SCYL2 Elisa Kits ranked by validation data
- Compare Top SCYL2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SCYL2 Gene
Domains & Families for SCYL2 Gene
Gene Families for SCYL2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for SCYL2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SCYL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6P3W7- Family:
-
- Belongs to the protein kinase superfamily.
Function for SCYL2 Gene
Molecular function for SCYL2 Gene
- UniProtKB/Swiss-Prot Function:
- Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system.
Phenotypes From GWAS Catalog for SCYL2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004672 | protein kinase activity | IEA | -- |
GO:0005102 | receptor binding | IPI | 19643732 |
GO:0005515 | protein binding | IPI | 19643732 |
GO:0005524 | ATP binding | IEA | -- |
Phenotypes for SCYL2 Gene
- MGI mutant phenotypes for SCYL2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SCYL2:
-
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Lamellipodia cells
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased homologous recombination repair frequency
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Decreased centriole number
Animal Models for SCYL2 Gene
- MGI Knock Outs for SCYL2:
-
- Scyl2 tm1.2Spel
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SCYL2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SCYL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SCYL2 gene
- Search ViGene Biosciences for SCYL2
CRISPR Products
-
OriGene CRISPR knockouts for SCYL2
- genomics-online: gRNA clones - Search results for 76 available SCYL2 gene related products
- Overview of 76 available SCYL2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- Applied Biological Materials CRISPR for SCYL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SCYL2
- GenScript: Design CRISPR guide RNA sequences for SCYL2
miRNA for SCYL2 Gene
- miRTarBase miRNAs that target SCYL2
miRNA Products
- Search ViGene Biosciences for SCYL2
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for SCYL2
- Browse OriGene Inhibitory RNA Products For SCYL2
- genomics-online: shRNA clones - Search results for 76 available SCYL2 gene related products
- Overview of 76 available SCYL2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
-
ViGene Biosciences ready-to-package AAV shRNAs for SCYL2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SCYL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SCYL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SCYL2
- genomics-online: cdna clones - Search results for 76 available SCYL2 gene related products
- Overview of 76 available SCYL2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- orf clones - Search results for 76 available SCYL2 gene related products
- Overview of 76 available SCYL2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- Applied Biological Materials Clones for SCYL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SCYL2
-
ViGene Biosciences adenoviral particle packaged cDNA for SCYL2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SCYL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SCYL2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCYL2 Gene
Localization for SCYL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SCYL2 Gene
- Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Note=According to PubMed:15809293, plasma membrane-associated in clathrin-coated vesicles. According to PubMed:16914521, colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005768 | endosome | IEA | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0010008 | endosome membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCYL2 Gene
Pathways & Interactions for SCYL2 Gene
Interacting Proteins for SCYL2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002092 | positive regulation of receptor internalization | IDA | 19643732 |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0008333 | endosome to lysosome transport | IDA | 19643732 |
GO:0090090 | negative regulation of canonical Wnt signaling pathway | IDA | 19643732 |
GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway | IDA | 19643732 |
No data available for Pathways by source and SIGNOR curated interactions for SCYL2 Gene
Transcripts for SCYL2 Gene
mRNA/cDNA for SCYL2 Gene
- (8) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (170) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SCYL2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SCYL2
- genomics-online: gRNA clones - Search results for 76 available SCYL2 gene related products
- Overview of 76 available SCYL2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- Applied Biological Materials CRISPR for SCYL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SCYL2
- GenScript: Design CRISPR guide RNA sequences for SCYL2
miRNA Products
- Search ViGene Biosciences for SCYL2
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for SCYL2
- Browse OriGene Inhibitory RNA Products For SCYL2
- genomics-online: shRNA clones - Search results for 76 available SCYL2 gene related products
- Overview of 76 available SCYL2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
-
ViGene Biosciences ready-to-package AAV shRNAs for SCYL2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SCYL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SCYL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SCYL2
- genomics-online: cdna clones - Search results for 76 available SCYL2 gene related products
- Overview of 76 available SCYL2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- orf clones - Search results for 76 available SCYL2 gene related products
- Overview of 76 available SCYL2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- Applied Biological Materials Clones for SCYL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SCYL2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCYL2 Gene
NURSA nuclear receptor signaling pathways regulating expression of SCYL2 Gene:
SCYL2SOURCE GeneReport for Unigene cluster for SCYL2 Gene:
Hs.506481Evidence on tissue expression from TISSUES for SCYL2 Gene
- Nervous system(4.5)
Primer Products
-
OriGene qPCR primer pairs for SCYL2
-
OriGene qPCR primer pairs and template standards for SCYL2
- genomics-online: primer clones - Search results for 76 available SCYL2 gene related products
- Overview of 76 available SCYL2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCYL2 Gene
Orthologs for SCYL2 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SCYL2 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | SCYL2 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | SCYL2 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | SCYL2 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | SCYL2 34 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Scyl2 33 |
|
||
mouse (Mus musculus) |
Mammalia | Scyl2 33 16 34 |
|
||
chicken (Gallus gallus) |
Aves | SCYL2 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | SCYL2 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | scyl2 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | SCYL2 34 |
|
OneToOne | |
si:ch211-244b2.1 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | CG1951 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002142 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | ZC581.9 34 |
|
OneToOne | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SCY1 34 36 |
|
OneToOne | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for SCYL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SCYL2 Gene
Pseudogenes.org Pseudogenes for SCYL2 Gene
No data available for Paralogs for SCYL2 Gene
Variants for SCYL2 Gene
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_041370 | A lung adenocarcinoma sample | p.Gln863His | |||
rs1000002371 | -- | 100,332,102(+) | A/G | intron_variant | |
rs1000015151 | -- | 100,297,739(+) | C/A | intron_variant | |
rs1000070133 | -- | 100,266,201(+) | C/T | upstream_transcript_variant | |
rs1000137175 | -- | 100,304,068(+) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2364259 | CNV | deletion | 18987734 |
esv2518688 | CNV | deletion | 19546169 |
esv2672785 | CNV | deletion | 23128226 |
esv2746277 | CNV | deletion | 23290073 |
esv3549674 | CNV | deletion | 23714750 |
esv3580426 | CNV | loss | 25503493 |
nsv1070124 | CNV | deletion | 25765185 |
nsv559964 | CNV | gain | 21841781 |
nsv958649 | CNV | deletion | 24416366 |
nsv977143 | CNV | duplication | 23825009 |
Additional Variant Information for SCYL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SCYL2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCYL2 Gene
Disorders for SCYL2 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
cataract 8, multiple types |
|
|
Additional Disease Information for SCYL2
No data available for UniProtKB/Swiss-Prot and Genatlas for SCYL2 Gene
Publications for SCYL2 Gene
- Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network. (PMID: 16914521) Düwel M … Ungewickell EJ (Molecular biology of the cell 2006) 3 4 22 58
- CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. (PMID: 15809293) Conner SD … Schmid SL (The Journal of biological chemistry 2005) 2 3 4 58
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
- CVAK104 is a novel regulator of clathrin-mediated SNARE sorting. (PMID: 17587408) Borner GH … Robinson MS (Traffic (Copenhagen, Denmark) 2007) 2 3 58
- Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. (PMID: 16903783) Schmid EM … McMahon HT (PLoS biology 2006) 3 4 58
Products for SCYL2 Gene
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- genomics-online: primer clones - Search results for 76 available SCYL2 gene related products
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- genomics-online: shRNA clones - Search results for 76 available SCYL2 gene related products
- Overview of 76 available SCYL2 gene related products
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Sources for SCYL2 Gene
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