Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SCYL2 Gene

protein-coding GIFtS: 53
GCID: GC12P100661

SCY1-Like 2 (S. Cerevisiae)

1 related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
SCY1-Like 2 (S. Cerevisiae)¹ ²
Coated Vesicle-Associated Kinase Of 104 KDa² ³
CVAK104² ³
SCY1-Like Protein 2²
KIAA1360³

External Ids:	HGNC: 19286¹	Entrez Gene: 55681²	Ensembl: ENSG00000136021⁷	UniProtKB: Q6P3W7³

Export aliases for SCYL2 gene to outside databases

Previous GC identifers: GC12P099164 GC12P097722

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SCYL2 Gene:

SCYL2 (SCY1-like 2 (S. cerevisiae)) is a protein-coding gene. Diseases associated with SCYL2 include breast cancer. GO annotations related to this gene include protein kinase activity and receptor binding.

UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7

Function: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated

vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro,

the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine.

According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent

trafficking between the TGN and/or the endosomal system

Gene Wiki entry for SCYL2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NT_029419.12 NC_018923.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SCYL2 gene promoter:
TBP Pax-2 Nkx2-5 STAT5A IRF-1 Pax-2a Pax-2b Zic3 Pax-4a ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCYL2 promoter sequence

Search SABiosciences Chromatin IP Primers for SCYL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCYL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1 Ensembl cytogenetic band: 12q23.1 HGNC cytogenetic band: 12q23.1

SCYL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCYL2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P100661: view genomic region (about GC identifiers)

Start:	100,660,918 bp from pter	End:	100,735,502 bp from pter
Size:	74,585 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7 (See protein sequence)

Recommended Name: SCY1-like protein 2

Size: 929 amino acids; 103709 Da

Subunit: Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex

Subcellular location: Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi

apparatus, trans-Golgi network membrane. Endosome membrane. Note=According to PubMed:15809293, plasma

membrane-associated in clathrin-coated vesicles. According to PubMed:16914521, colocalizes to the trans-Golgi

network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3

complexes

Sequence caution: Sequence=BAA91778.1; Type=Erroneous initiation; Sequence=BAB14869.1; Type=Erroneous initiation;

Sequence=BAB55194.1; Type=Erroneous initiation;

Secondary accessions: A8KAB5 Q96EF4 Q96ST4 Q9H7V5 Q9NVH3 Q9P2I7

Explore the universe of human proteins at neXtProt for SCYL2: NX_Q6P3W7

Explore proteomics data for SCYL2 at MOPED

Post-translational modifications:

UniProtKB: According to PubMed:15809293, autophosphorylated in presence of poly-L-lysine

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q6P3W7

SCYL2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_060458.3

ENSEMBL proteins:

ENSP00000448366 ENSP00000450294 ENSP00000354061 ENSP00000449567 ENSP00000448400

Human Recombinant Protein Products for SCYL2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for SCYL2 OriGene Custom MassSpec OriGene Custom Protein Services for SCYL2
	GenScript Custom Purified and Recombinant Proteins Services for SCYL2
	Novus Biologicals SCYL2 Proteins Novus Biologicals SCYL2 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for SCYL2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	IEA	--
GO:0010008	endosome membrane	IEA	--
GO:0030136	clathrin-coated vesicle	IEA	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

SCYL2 for ontologies About GeneDecksing

SCYL2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SCYL2
	GenScript Custom Superior Antibodies Services for SCYL2
	Novus Biologicals SCYL2 Antibodies
	Abcam antibodies for SCYL2
	Cloud-Clone Corp. Antibodies for SCYL2
	ThermoFisher Antibodies for SCYL2
	LSBio Antibodies in human, mouse, rat for SCYL2

Assay Products for SCYL2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SCYL2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SCYL2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SCYL2 Cloud-Clone Corp. CLIAs for SCYL2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IUPHAR Guide to PHARMACOLOGY protein family classification: SCY1-like 2 (S. cerevisiae)

SCY1 family

4 InterPro protein domains:

IPR011989 ARM-like

IPR011009 Kinase-like_dom

IPR000719 Prot_kinase_cat_dom

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q6P3W7

ProtoNet protein and cluster: Q6P3W7

1 Blocks protein domain: IPB000357 HEAT repeat

UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7

Similarity: Belongs to the protein kinase superfamily

Similarity: Contains 1 HEAT repeat

Similarity: Contains 1 protein kinase domain

SCYL2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SCYL2_HUMAN, Q6P3W7

Function: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated

vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro,

the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine.

According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent

trafficking between the TGN and/or the endosomal system

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	IEA	--
GO:0005102	receptor binding	IPI	19643732
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	19643732
GO:0005524	ATP binding	IEA	--

SCYL2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SCYL2:

Increased number of small and

Proliferating cells

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for SCYL2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCYL2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCYL2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCYL2

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCYL2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SCYL2:
		hsa-miR-323-3p hsa-miR-1304 hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-561 hsa-miR-524-5p hsa-miR-1827 hsa-miR-34a*

		SwitchGear 3'UTR luciferase reporter plasmid: SCYL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SCYL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCYL2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SCYL2
			Sirion Biotech Customized adenovirus for overexpression of SCYL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for SCYL2 (see all 6) OriGene ORF clones in mouse, rat for SCYL2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SCYL2 (NM_017988)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCYL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL2
		Sirion Biotech Customized lentivirus for stable overexpression of SCYL2 Customized lentivirus expression plasmids for stable overexpression of SCYL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SCYL2
		Search LifeMap BioReagents cell lines for SCYL2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SCYL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/787 Interacting proteins for SCYL2 (Q6P3W7^{2, 3} ENSP00000354061⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 787)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCT6A	P40227²^,³	MINT-7945693 MINT-7947479 I2D: score=1
ZFYVE9	O95405²^,³	MINT-62055 I2D: score=3
CDC5L	Q99459², ENSP00000360532⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000360532
SNW1	Q13573², ENSP00000261531⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000261531
ARRB1	P49407³, ENSP00000377141⁴	I2D: score=1 STRING: ENSP00000377141

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002092	positive regulation of receptor internalization	IDA	19643732
GO:0006468	protein phosphorylation	--	--
GO:0008333	endosome to lysosome transport	IDA	19643732
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	IDA	19643732
GO:2000286	receptor internalization involved in canonical Wnt receptor signaling pathway	IDA	19643732

SCYL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SCYL2

Search CenterWatch for drugs/clinical trials and news about SCYL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SCYL2 gene:

NM_017988.4

Unigene Cluster for SCYL2:

SCY1-like 2 (S. cerevisiae)

Hs.506481 [show with all ESTs]

Unigene Representative Sequence: AB037781

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000549687(uc009ztw.1 uc001thm.1) ENST00000548392 ENST00000550067

ENST00000360820(uc001thn.3) ENST00000549486 ENST00000550251 ENST00000553148

ENST00000548871 ENST00000547202 ENST00000547735

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCYL2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SCYL2:
		hsa-miR-323-3p hsa-miR-1304 hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-561 hsa-miR-524-5p hsa-miR-1827 hsa-miR-34a*

		SwitchGear 3'UTR luciferase reporter plasmid: SCYL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SCYL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCYL2

Clone Products:		OriGene clones in human, mouse for SCYL2 (see all 6) OriGene ORF clones in mouse, rat for SCYL2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SCYL2 (NM_017988)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCYL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL2
		Sirion Biotech Customized lentivirus for stable overexpression of SCYL2 Customized lentivirus expression plasmids for stable overexpression of SCYL2

Primer Products:		OriGene qPCR primer pairs and template standards for SCYL2 OriGene qSTAR qPCR primer pairs in human, mouse for SCYL2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SCYL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCYL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCYL2

Additional mRNA sequence:

AB037781.1 AK000936.1 AK001597.1 AK024274.1 AK026160.1 AK027551.1 AK125091.1 AK292980.1

AL133044.1 BC011525.1 BC012387.2 BC063798.1

16 DOTS entries:

DT.113777 DT.99975660 DT.92017103 DT.121127782 DT.92024438 DT.91989189 DT.99989935 DT.121127753

DT.40252890 DT.91767850 DT.95274467 DT.121127752 DT.121127758 DT.99980806 DT.99980828 DT.91767854

24/170 AceView cDNA sequences (see all 170):

AW613144 AA496859 AI911584 CR621893 CD652001 AI143061 BU521019 CB122856

AW628212 AA504613 BM768998 CB111100 BU790242 BM837173 AI648671 BC012387

AA504708 AW630869 AI613306 AW148372 BE047280 AA811214 AA789178 AA496898

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCYL2 expression in normal human tissues (normalized intensities) SCYL2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAAGAAAAAG

About this image

SCYL2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/29 selected tissues (see all 29) fully expand


Testis (Reproductive System) fully expand to see all 4 entries
Leydig Cells Testis Interstitium
seminal vesicle ; glandular cells

Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Epithelium
cervix, uterine ; squamous epithelial cells

Blood (Respiratory System) fully expand to see all 3 entries
lung ; macrophages
cmps

Colon (Gastrointestinal Tract) fully expand to see all 3 entries
colon ; peripheral nerve/ganglion

See SCYL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCYL2

SOURCE GeneReport for Unigene cluster: Hs.506481

SABiosciences Custom PCR Arrays for SCYL2

Primer Products:		OriGene qPCR primer pairs and template standards for SCYL2 OriGene qSTAR qPCR primer pairs in human, mouse for SCYL2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SCYL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCYL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCYL2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCYL2 gene from 9/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Scyl2^{1 , 5}	SCY1-like 2 (S. cerevisiae)^{1, 5}	88.81(n)¹ 93.11(a)¹		10 (45.05 cM)⁵ 213326¹ NM_198021.2¹ NP_932138.1¹ 89638721⁵
chicken (Gallus gallus)	Aves	SCYL2¹	SCY1-like 2 (S. cerevisiae)	79.89(n) 83.82(a)		417930 NM_001030751.1 NP_001025922.1
lizard (Anolis carolinensis)	Reptilia	SCYL2⁶	SCY1-like 2 (S. cerevisiae)	83(a)	1 ↔ 1	5(28679670-28710973)
zebrafish (Danio rerio)	Actinopterygii	SCYL2⁶	SCY1-like 2 (S. cerevisiae)	70(a)	1 ↔ 1	4(25143657-25165222)
fruit fly (Drosophila melanogaster)	Insecta	CG1951¹	CG1951	51.74(n) 47.61(a)		43423 NM_143398.3 NP_651655.1
worm (Caenorhabditis elegans)	Secernentea	ZC581.9⁶	Protein ZC581.9	20(a)	1 ↔ 1	I(6665120-6670409)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SCY1(YGL083W)⁴	Putative kinase, suppressor of GTPase mutant, similar more	--		7(353058-355472) 852797 NP_011432.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G22870¹	protein kinase-like protein with ARM repeat domain-containing more	45.29(n) 32.65(a)		838892 NM_102133.2 NP_173700.2
rice (Oryza sativa)	Liliopsida	Os01g0616100¹	hypothetical protein	42.01(n) 29.08(a)		4326650 NM_001050110.1 NP_001043575.2

ENSEMBL Gene Tree for SCYL2 (if available)
TreeFam Gene Tree for SCYL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SCYL2 gene

SCYL2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SCYL2
PGOHUM00000261348

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_041370⁴		A lung adenocarcinoma sample⁴	--	see VAR_041370	2	Q H	mis⁴		0	--	--	--	--
VAR_041369⁴		--	--	see VAR_041369	2	T S	mis⁴		0	--	--	--	--
rs146284401^1,2		--	100662864(+)	`AATGCA/CGACCT`	1	--	int¹		0	--	--	--	--
rs181369966^1,2		--	100663043(+)	`TGTTCC/TCCTGC`	1	--	int¹		0	--	--	--	--
rs185948787^1,2		--	100663075(+)	`ATGCTA/CCTTCC`	1	--	int¹		0	--	--	--	--
rs200596986^1,2		--	100663105(+)	`CTTTC-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs75186611^1,2	C,F	--	100663137(+)	`TCATTC/TAGCTC`	1	--	int¹		1		EA	120
rs192148754^1,2		--	100663248(+)	`ATTAGA/TTGTTC`	1	--	int¹		0	--	--	--	--
rs183784934^1,2		--	100663323(+)	`AATGGA/GCCAAG`	1	--	int¹		0	--	--	--	--
rs189248244^1,2		--	100663365(+)	`TGTTAA/GTCCTT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SCYL2 (100660918 - 100735502 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for SCYL2: About this table

Variant ID	Type	Subtype	PubMed ID
esv2746277	CNV	Deletion	23290073
esv2672785	CNV	Deletion	23128226
esv2518688	CNV	Deletion	19546169
esv2364259	CNV	Deletion	18987734

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCYL2

DNA2.0 Custom Variant and Variant Library Synthesis for SCYL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

2 diseases for SCYL2: About MalaCards

breast cancer

SCYL2 for disorders About GeneDecksing

Export disorders for SCYL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SCYL2 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with SCYL2)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2, 3} Nagase T.... Ohara O. (2000)
Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network. (PubMed id 16914521)^{1, 2, 9} Duewel M. and Ungewickell E.J. (2006)
Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. (PubMed id 16903783)^{1, 2} Schmid E.M....McMahon H.T. (2006)
CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. (PubMed id 15809293)^{1, 2} Conner S.D. and Schmid S.L. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genome-wide association study identifies a novel susce ptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese. (PubMed id 23341777)¹ Dong J....Shen H. (2013)
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)¹ Cox J.L....Rizzino A. (2013)
Interferon-induced SCYL2 limits release of HIV-1 by tr iggering PP2A-mediated dephosphorylation of the viral protein Vpu. (PubMed id 23047923)¹ Miyakawa K....Ryo A. (2012)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55681	HGNC: 19286	AceView: FLJ10074	Ensembl:ENSG00000136021	euGenes: HUgn55681
ECgene: SCYL2	H-InvDB: SCYL2

(According to HUGE)
About This Section

HUGE: KIAA1360

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SCYL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SCYL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SCYL2 gene:
Search GeneIP for patents involving SCYL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for SCYL2
	OriGene qPCR primer pairs and template standards for SCYL2		OriGene Protein Over-expression Lysate for SCYL2
	OriGene Custom Mass Spec		OriGene clones in human, mouse for SCYL2
	OriGene qSTAR qPCR primer pairs in human, mouse for SCYL2		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for SCYL2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SCYL2		OriGene Custom Protein Services for SCYL2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCYL2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCYL2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCYL2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCYL2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCYL2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCYL2

	GenScript Custom Purified and Recombinant Proteins Services for SCYL2		GenScript cDNA clones with any tag delivered in your preferred vector for SCYL2
	GenScript Custom Assay Services for SCYL2		GenScript Custom Superior Antibodies Services for SCYL2
	GenScript Custom overexpressing Cell Line Services for SCYL2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SCYL2 promoter
	Search Chromatin IP Primers for SCYL2
	RT² qPCR Primer Assay in human, mouse, rat SCYL2
	Search GNC Networks for SCYL2
	SABiosciences Custom PCR Arrays for SCYL2

Search Tocris compounds for SCYL2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SCYL2 antibodies
	SCYL2 proteins
	SCYL2 lysates

	Antibodies for SCYL2
	See all of Abcam's Antibodies, Kits and Proteins for SCYL2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for SCYL2
	Antibodies for SCYL2
	ELISAs for SCYL2
	CLIAs for SCYL2

Search LifeMap BioReagents cell lines for SCYL2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL2

	SwitchGear 3'UTR luciferase reporter plasmids for SCYL2
	SwitchGear Promoter luciferase reporter plasmids for SCYL2

ThermoFisher Antibodies for SCYL2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for SCYL2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCYL2

Customized:

	lentivirus for stable overexpression of SCYL2
	lentivirus expression plasmids for stable overexpression of SCYL2
	adenovirus for overexpression of SCYL2

LSBio Antibodies in human, mouse, rat for SCYL2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SCYL2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

SCYL2 Gene

SCY1-Like 2 (S. Cerevisiae)

Aliases
for SCYL2 gene

Summaries
for SCYL2 gene

Genomic Views
for SCYL2 gene

Proteins
for SCYL2 gene

Protein Domains /
Families
for SCYL2 gene

Function
for SCYL2 gene

Pathways & Interactions
for SCYL2 gene

Drugs & Compounds
for SCYL2 gene

Transcripts
for SCYL2 gene

Expression
for SCYL2 gene

Orthologs
for SCYL2 gene

Paralogs
for SCYL2 gene

Genomic Variants
for SCYL2 gene

Disorders / Diseases
for SCYL2 gene

Publications
for SCYL2 gene

External Searches for SCYL2 gene

Genome Databases showing SCYL2 gene

Other Databases showing SCYL2 gene

Specialized Databases showing SCYL2 gene

Intellectual Property
for SCYL2 gene

Products
for SCYL2 gene

View Random Gene

Advanced Search

Export list of displayed genes

SCYL2 Gene

SCY1-Like 2 (S. Cerevisiae)

Aliasesfor SCYL2 gene

Summariesfor SCYL2 gene

Genomic Viewsfor SCYL2 gene

Proteinsfor SCYL2 gene

Protein Domains /Familiesfor SCYL2 gene

Functionfor SCYL2 gene

Pathways & Interactionsfor SCYL2 gene

Drugs & Compoundsfor SCYL2 gene

Transcriptsfor SCYL2 gene

Expression for SCYL2 gene

Orthologsfor SCYL2 gene

Paralogsfor SCYL2 gene

Genomic Variantsfor SCYL2 gene

Disorders / Diseasesfor SCYL2 gene

Publicationsfor SCYL2 gene

External Searches for SCYL2 gene

Genome Databases showing SCYL2 gene

Other Databases showing SCYL2 gene

Specialized Databases showing SCYL2 gene

Intellectual Propertyfor SCYL2 gene

Productsfor SCYL2 gene

View Random Gene

Aliases
for SCYL2 gene

Summaries
for SCYL2 gene

Genomic Views
for SCYL2 gene

Proteins
for SCYL2 gene

Protein Domains /
Families
for SCYL2 gene

Function
for SCYL2 gene

Pathways & Interactions
for SCYL2 gene

Drugs & Compounds
for SCYL2 gene

Transcripts
for SCYL2 gene

Expression
for SCYL2 gene

Orthologs
for SCYL2 gene

Paralogs
for SCYL2 gene

Genomic Variants
for SCYL2 gene

Disorders / Diseases
for SCYL2 gene

Publications
for SCYL2 gene

Intellectual Property
for SCYL2 gene

Products
for SCYL2 gene