SCYL2 Gene
protein-coding GIFtS: 50
GCID: GC12P100661
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SCY1-like 2 (S. cerevisiae)
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Aliases for SCYL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| SCY1-Like 2 (S. Cerevisiae)1 2 | | KIAA13601 3 | | Coated Vesicle-Associated Kinase Of 104 KDa2 3 | | CVAK1042 3 | | SCY1-Like Protein 22 |
Export aliases for SCYL2 gene to outside databasesPrevious GC identifers: GC12P099164 GC12P097722 |
Summaries for SCYL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7Function: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coatedvesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, thebeta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According toPubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between theTGN and/or the endosomal system Gene Wiki entry for SCYL2
|
Genomic Views for SCYL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SCYL2 gene promoter: TBP Pax-2 Nkx2-5 STAT5A IRF-1 Pax-2a Pax-2b Zic3 Pax-4a ATF6 Other transcription factors
Search SABiosciences Chromatin IP Primers for SCYL2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCYL2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q23.1 Ensembl cytogenetic band: 12q23.1 HGNC cytogenetic band: 12q23.1SCYL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P100661: view genomic region
(about GC identifiers)
Start:
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100,660,918 bp from pter |
End:
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100,735,502 bp from pter |
Size:
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74,585 bases |
Orientation:
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plus strand |
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Proteins for SCYL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7 (See
protein sequence)Recommended Name: SCY1-like protein 2 Size: 929 amino acids; 103709 Da
Subunit: Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex
Subcellular location: Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus,trans-Golgi network membrane. Endosome membrane. Note=According to PubMed:15809293, plasma membrane-associated inclathrin-coated vesicles. According to PubMed:16914521, colocalizes to the trans-Golgi network (TGN) and to endosomalmembranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes
Sequence caution: Sequence=BAA91778.1; Type=Erroneous initiation; Sequence=BAB14869.1; Type=Erroneous initiation;Sequence=BAB55194.1; Type=Erroneous initiation;
Secondary accessions: A8KAB5 Q96EF4 Q96ST4 Q9H7V5 Q9NVH3 Q9P2I7Explore the universe of human proteins at neXtProt for SCYL2: NX_Q6P3W7
Post-translational modifications:
According to PubMed:15809293, autophosphorylated in presence of poly-L-lysine1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P3W7 SCYL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060458.3 ENSEMBL proteins: ENSP00000448366 ENSP00000450294 ENSP00000354061 ENSP00000449567 ENSP00000448400 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SCYL2 for ontologies About GeneDecksing
SCYL2 Antibody Products: Assay Products for SCYL2: |
Protein
Domains / Families for SCYL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCYL2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P3W7ProtoNet protein and cluster: Q6P3W7 1 Blocks protein family: IPB000357 HEAT repeat
UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7Similarity: Belongs to the protein kinase superfamilySimilarity: Contains 1 HEAT repeatSimilarity: Contains 1 protein kinase domain |
Function for SCYL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7Function: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coatedvesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, thebeta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According toPubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between theTGN and/or the endosomal system
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCYL2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCYL2 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SCYL2 (NM_017988) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCYL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL2  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SCYL2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SCYL2:
|
Pathways & Interactions for SCYL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCYL2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
 5/750 Interacting proteins for SCYL2 (Q6P3W72, 3 ENSP000003540614) via UniProtKB, MINT, STRING, and/or I2D (see all 750)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
SCYL2 for ontologies About GeneDecksing
|
Drugs & Compounds for SCYL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SCYL2 Search CenterWatch for drugs/clinical trials and news about SCYL2 
|
Transcripts for SCYL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SCYL2 gene: NM_017988.4 Unigene Cluster for SCYL2: SCY1-like 2 (S. cerevisiae) Hs.506481 [show with all ESTs]Unigene Representative Sequence: AB03778110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000549687(uc009ztw.1 uc001thm.1) ENST00000548392 ENST00000550067 ENST00000360820(uc001thn.3) ENST00000549486 ENST00000550251 ENST00000553148 ENST00000548871 ENST00000547202 ENST00000547735
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCYL2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCYL2 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SCYL2 (NM_017988) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCYL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL2  |
Additional cDNA sequence: AB037781.1 AK000936.1 AK001597.1 AK024274.1 AK026160.1 AK027551.1 AK125091.1 AK292980.1 AL133044.1 BC011525.1 BC012387.2 BC063798.1 16 DOTS entries: DT.99975660 DT.113777 DT.92017103 DT.121127782 DT.92024438 DT.91989189 DT.99989935 DT.121127753 DT.40252890 DT.91767850 DT.95274467 DT.121127752 DT.121127758 DT.99980806 DT.99980828 DT.91767854 24/170 AceView cDNA sequences (see all 170): AW628212 AI613306 AK000936 BM786779 BM837173 BC012387 AK001597 AW206305 AI911584 CA395939 AW630869 C00727 CB129787 AW613144 AA811901 BQ015311 CB122856 BE549605 AA975189 BU521019 AI648671 AA504613 AI143061 AA811214 GeneLoc Exon Structure
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Expression for SCYL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCYL2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AAAGAAAAAG
About this image See SCYL2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SCYL2
SOURCE GeneReport for Unigene cluster: Hs.506481 SABiosciences Custom PCR Arrays for SCYL2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCYL2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCYL2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCYL2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCYL2 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL2 |
Orthologs for SCYL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SCYL2 gene from 8/26 species (see all 26) About this table
ENSEMBL Gene Tree for SCYL2 (if available) TreeFam Gene Tree for SCYL2 (if available)  |
Paralogs for SCYL2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SCYL2 gene
SCYL2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SCYL2 PGOHUM00000261348
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Genomic Variants for SCYL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 12 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for SCYL2 (100660918 - 100735502 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for SCYL2 1 CNV: 101602 1 Indel: 45100  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCYL2 |
|
Disorders
/ Diseases for SCYL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCYL2 for disorders About GeneDecksing
2 diseases for SCYL2: About MalaCardstreacher collins syndrome malaria Export disorders for SCYL2 gene to outside databases
|
Publications for SCYL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCYL2 gene, integrated from 9 sources (see all 19): (articles sorted by number of sources associating them with SCYL2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network. (PubMed id 16914521)1, 2, 9 Duewel M. and Ungewickell E.J. (2006)
- Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. (PubMed id 16903783)1, 2 Schmid E.M....McMahon H.T. (2006)
- CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. (PubMed id 15809293)1, 2 Conner S.D. and Schmid S.L. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for SCYL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SCYL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCYL2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SCYL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SCYL2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SCYL2 gene: Search GeneIP for patents involving SCYL2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SCYL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for SCYL2 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCYL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCYL2 | | OriGene Protein Over-expression Lysate for SCYL2 | | Browse OriGene Fluorogenic Cell Assay Kits | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for SCYL2 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCYL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCYL2 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for SCYL2 | | OriGene Custom Protein Services for SCYL2 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCYL2 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCYL2 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCYL2 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCYL2 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCYL2 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCYL2 |
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| | | Search Tocris compounds for SCYL2 |
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 | | SCYL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL2 |
|  |  |  | | | ThermoFisher Antibodies for SCYL2 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL2 |
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