Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCYL2 Gene

protein-coding   GIFtS: 53
GCID: GC12P100661

SCY1-Like 2 (S. Cerevisiae)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SCY1-Like 2 (S. Cerevisiae)1 2
Coated Vesicle-Associated Kinase Of 104 KDa2 3
CVAK1042 3
SCY1-Like Protein 22
KIAA13603

External Ids:    HGNC: 192861   Entrez Gene: 556812   Ensembl: ENSG000001360217   UniProtKB: Q6P3W73   

Export aliases for SCYL2 gene to outside databases

Previous GC identifers: GC12P099164 GC12P097722


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SCYL2 Gene: 
SCYL2 (SCY1-like 2 (S. cerevisiae)) is a protein-coding gene. Diseases associated with SCYL2 include breast cancer. GO annotations related to this gene include protein kinase activity and receptor binding.

UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7
Function: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated
vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro,
the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine.
According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent
trafficking between the TGN and/or the endosomal system

Gene Wiki entry for SCYL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCYL2 gene promoter:
         TBP   Pax-2   Nkx2-5   STAT5A   IRF-1   Pax-2a   Pax-2b   Zic3   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCYL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCYL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCYL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1   Ensembl cytogenetic band:  12q23.1   HGNC cytogenetic band: 12q23.1

SCYL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCYL2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P100661:  view genomic region     (about GC identifiers)

Start:
100,660,918 bp from pter      End:
100,735,502 bp from pter
Size:
74,585 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7 (See protein sequence)
Recommended Name: SCY1-like protein 2  
Size: 929 amino acids; 103709 Da
Subunit: Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex
Subcellular location: Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi
apparatus, trans-Golgi network membrane. Endosome membrane. Note=According to PubMed:15809293, plasma
membrane-associated in clathrin-coated vesicles. According to PubMed:16914521, colocalizes to the trans-Golgi
network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3
complexes
Sequence caution: Sequence=BAA91778.1; Type=Erroneous initiation; Sequence=BAB14869.1; Type=Erroneous initiation;
Sequence=BAB55194.1; Type=Erroneous initiation;
Secondary accessions: A8KAB5 Q96EF4 Q96ST4 Q9H7V5 Q9NVH3 Q9P2I7

Explore the universe of human proteins at neXtProt for SCYL2: NX_Q6P3W7

Explore proteomics data for SCYL2 at MOPED 

Post-translational modifications:

  • UniProtKB: According to PubMed:15809293, autophosphorylated in presence of poly-L-lysine
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P3W7

  • SCYL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SCYL2 Protein Expression
    REFSEQ proteins: NP_060458.3  
    ENSEMBL proteins: 
     ENSP00000448366   ENSP00000450294   ENSP00000354061   ENSP00000449567   ENSP00000448400  

    Human Recombinant Protein Products for SCYL2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SCYL2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SCYL2
    GenScript Custom Purified and Recombinant Proteins Services for SCYL2
    Novus Biologicals SCYL2 Proteins
    Novus Biologicals SCYL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCYL2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0010008endosome membrane IEA--
    GO:0030136clathrin-coated vesicle IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    SCYL2 for ontologies           About GeneDecksing



    SCYL2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SCYL2
    GenScript Custom Superior Antibodies Services for SCYL2
    Novus Biologicals SCYL2 Antibodies
    Abcam antibodies for SCYL2
    Cloud-Clone Corp. Antibodies for SCYL2 
    ThermoFisher Antibodies for SCYL2
    LSBio Antibodies in human, mouse, rat for SCYL2 

    Assay Products for SCYL2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SCYL2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCYL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SCYL2 
    Cloud-Clone Corp. CLIAs for SCYL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: SCY1-like 2 (S. cerevisiae) 
    SCY1 family

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6P3W7

    ProtoNet protein and cluster: Q6P3W7

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: SCYL2_HUMAN, Q6P3W7
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 1 HEAT repeat
    Similarity: Contains 1 protein kinase domain


    SCYL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCYL2_HUMAN, Q6P3W7
    Function: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated
    vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro,
    the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine.
    According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent
    trafficking between the TGN and/or the endosomal system

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0005102receptor binding IPI19643732
    GO:0005488binding ----
    GO:0005515protein binding IPI19643732
    GO:0005524ATP binding IEA--
         
    SCYL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SCYL2:
     Increased number of small and   Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SCYL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCYL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCYL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCYL2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCYL2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate SCYL2:
    hsa-miR-323-3p hsa-miR-1304 hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-561 hsa-miR-524-5p hsa-miR-1827 hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidSCYL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SCYL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCYL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SCYL2
    Sirion Biotech Customized adenovirus for overexpression of SCYL2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SCYL2 (see all 6)
    OriGene ORF clones in mouse, rat for SCYL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCYL2 (NM_017988)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCYL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL2
    Sirion Biotech Customized lentivirus for stable overexpression of SCYL2 
                         Customized lentivirus expression plasmids for stable overexpression of SCYL2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SCYL2
    Search LifeMap BioReagents cell lines for SCYL2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCYL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/787 Interacting proteins for SCYL2 (Q6P3W72, 3 ENSP000003540614) via UniProtKB, MINT, STRING, and/or I2D (see all 787)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCT6AP402272, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ZFYVE9O954052, 3MINT-62055 I2D: score=3 
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    ARRB1P494073, ENSP000003771414I2D: score=1 STRING: ENSP00000377141
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002092positive regulation of receptor internalization IDA19643732
    GO:0006468protein phosphorylation ----
    GO:0008333endosome to lysosome transport IDA19643732
    GO:0090090negative regulation of canonical Wnt receptor signaling pathway IDA19643732
    GO:2000286receptor internalization involved in canonical Wnt receptor signaling pathway IDA19643732

    SCYL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCYL2

    Search CenterWatch for drugs/clinical trials and news about SCYL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SCYL2 gene: 
    NM_017988.4  

    Unigene Cluster for SCYL2:

    SCY1-like 2 (S. cerevisiae)
    Hs.506481  [show with all ESTs]
    Unigene Representative Sequence: AB037781
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000549687(uc009ztw.1 uc001thm.1) ENST00000548392 ENST00000550067
    ENST00000360820(uc001thn.3) ENST00000549486 ENST00000550251 ENST00000553148
    ENST00000548871 ENST00000547202 ENST00000547735
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCYL2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate SCYL2:
    hsa-miR-323-3p hsa-miR-1304 hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-561 hsa-miR-524-5p hsa-miR-1827 hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidSCYL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SCYL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCYL2
    Clone
    Products:
         
    OriGene clones in human, mouse for SCYL2 (see all 6)
    OriGene ORF clones in mouse, rat for SCYL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCYL2 (NM_017988)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCYL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL2
    Sirion Biotech Customized lentivirus for stable overexpression of SCYL2 
                         Customized lentivirus expression plasmids for stable overexpression of SCYL2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SCYL2
    OriGene qSTAR qPCR primer pairs in human, mouse for SCYL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCYL2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCYL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCYL2

    Additional mRNA sequence: 

    AB037781.1 AK000936.1 AK001597.1 AK024274.1 AK026160.1 AK027551.1 AK125091.1 AK292980.1 
    AL133044.1 BC011525.1 BC012387.2 BC063798.1 

    16 DOTS entries:

    DT.113777  DT.99975660  DT.92017103  DT.121127782  DT.92024438  DT.91989189  DT.99989935  DT.121127753 
    DT.40252890  DT.91767850  DT.95274467  DT.121127752  DT.121127758  DT.99980806  DT.99980828  DT.91767854 

    24/170 AceView cDNA sequences (see all 170):

    AW613144 AA496859 AI911584 CR621893 CD652001 AI143061 BU521019 CB122856 
    AW628212 AA504613 BM768998 CB111100 BU790242 BM837173 AI648671 BC012387 
    AA504708 AW630869 AI613306 AW148372 BE047280 AA811214 AA789178 AA496898 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCYL2 expression in normal human tissues (normalized intensities)      SCYL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAAAAAG
    SCYL2 Expression
    About this image


    SCYL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium
             cervix, uterine ; squamous epithelial cells   
     
     Blood (Respiratory System)    fully expand to see all 3 entries
             lung ; macrophages   
             cmps   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See SCYL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCYL2

    SOURCE GeneReport for Unigene cluster: Hs.506481
        SABiosciences Custom PCR Arrays for SCYL2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SCYL2
    OriGene qSTAR qPCR primer pairs in human, mouse for SCYL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCYL2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCYL2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCYL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SCYL2 gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scyl21 , 5 SCY1-like 2 (S. cerevisiae)1, 5 88.81(n)1
    93.11(a)1
      10 (45.05 cM)5
    2133261  NM_198021.21  NP_932138.11 
     896387215 
    chicken
    (Gallus gallus)
    Aves SCYL21 SCY1-like 2 (S. cerevisiae) 79.89(n)
    83.82(a)
      417930  NM_001030751.1  NP_001025922.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCYL26
    SCY1-like 2 (S. cerevisiae)
    83(a)
    1 ↔ 1
    5(28679670-28710973)
    zebrafish
    (Danio rerio)
    Actinopterygii SCYL26
    SCY1-like 2 (S. cerevisiae)
    70(a)
    1 ↔ 1
    4(25143657-25165222)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG19511 CG1951 51.74(n)
    47.61(a)
      43423  NM_143398.3  NP_651655.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZC581.96
    Protein ZC581.9
    20(a)
    1 ↔ 1
    I(6665120-6670409)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCY1(YGL083W)4 Putative kinase, suppressor of GTPase mutant, similar more   --   7(353058-355472) 852797  NP_011432.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G228701 protein kinase-like protein with ARM repeat domain-containing more 45.29(n)
    32.65(a)
      838892  NM_102133.2  NP_173700.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g06161001 hypothetical protein 42.01(n)
    29.08(a)
      4326650  NM_001050110.1  NP_001043575.2 


    ENSEMBL Gene Tree for SCYL2 (if available)
    TreeFam Gene Tree for SCYL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCYL2 gene

    SCYL2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SCYL2
    PGOHUM00000261348


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1315 SNPs in SCYL2 are shown (see all 1315)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413704
    A lung adenocarcinoma sample4--see VAR_0413702 Q H mis40--------
    VAR_0413694
    ----see VAR_0413692 T S mis40--------
    rs1462844011,2
    --100662864(+) AATGCA/CGACCT 1 -- int10--------
    rs1813699661,2
    --100663043(+) TGTTCC/TCCTGC 1 -- int10--------
    rs1859487871,2
    --100663075(+) ATGCTA/CCTTCC 1 -- int10--------
    rs2005969861,2
    --100663105(+) CTTTC-/TTTTTT 1 -- int10--------
    rs751866111,2
    C,F--100663137(+) TCATTC/TAGCTC 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1921487541,2
    --100663248(+) ATTAGA/TTGTTC 1 -- int10--------
    rs1837849341,2
    --100663323(+) AATGGA/GCCAAG 1 -- int10--------
    rs1892482441,2
    --100663365(+) TGTTAA/GTCCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SCYL2 (100660918 - 100735502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SCYL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746277CNV Deletion23290073
    esv2672785CNV Deletion23128226
    esv2518688CNV Deletion19546169
    esv2364259CNV Deletion18987734

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SCYL2
    DNA2.0 Custom Variant and Variant Library Synthesis for SCYL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SCYL2:    About MalaCards
    breast cancer    


    SCYL2 for disorders           About GeneDecksing


    Export disorders for SCYL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCYL2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with SCYL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network. (PubMed id 16914521)1, 2, 9 Duewel M. and Ungewickell E.J. (2006)
    3. Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. (PubMed id 16903783)1, 2 Schmid E.M....McMahon H.T. (2006)
    4. CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. (PubMed id 15809293)1, 2 Conner S.D. and Schmid S.L. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Genome-wide association study identifies a novel susce ptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese. (PubMed id 23341777)1 Dong J....Shen H. (2013)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    9. Interferon-induced SCYL2 limits release of HIV-1 by tr iggering PP2A-mediated dephosphorylation of the viral protein Vpu. (PubMed id 23047923)1 Miyakawa K....Ryo A. (2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55681 HGNC: 19286 AceView: FLJ10074 Ensembl:ENSG00000136021 euGenes: HUgn55681
    ECgene: SCYL2 H-InvDB: SCYL2

    (According to HUGE)
    About This Section
    HUGE: KIAA1360

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCYL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCYL2 gene:
    Search GeneIP for patents involving SCYL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SCYL2  
     OriGene qPCR primer pairs and template standards for SCYL2   OriGene Protein Over-expression Lysate for SCYL2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SCYL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SCYL2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SCYL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SCYL2   OriGene Custom Protein Services for SCYL2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCYL2
     QIAGEN SeqTarget long-range PCR primers for resequencing SCYL2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCYL2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCYL2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCYL2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCYL2
     GenScript Custom Purified and Recombinant Proteins Services for SCYL2 GenScript cDNA clones with any tag delivered in your preferred vector for SCYL2
     GenScript Custom Assay Services for SCYL2 GenScript Custom Superior Antibodies Services for SCYL2
     GenScript Custom overexpressing Cell Line Services for SCYL2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SCYL2 promoter
     Search Chromatin IP Primers for SCYL2
     RT2 qPCR Primer Assay in human, mouse, rat SCYL2
     Search GNC Networks for SCYL2
     SABiosciences Custom PCR Arrays for SCYL2
     Search Tocris compounds for SCYL2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SCYL2 antibodies
     SCYL2 proteins
     SCYL2 lysates
     Antibodies for SCYL2
     See all of Abcam's Antibodies, Kits and Proteins for SCYL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SCYL2
     Antibodies for SCYL2
     ELISAs for SCYL2
     CLIAs for SCYL2
     Search LifeMap BioReagents cell lines for SCYL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL2
     SwitchGear 3'UTR luciferase reporter plasmids for SCYL2
     SwitchGear Promoter luciferase reporter plasmids for SCYL2
     ThermoFisher Antibodies for SCYL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SCYL2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCYL2
    Customized:
     lentivirus for stable overexpression of SCYL2
     lentivirus expression plasmids for stable overexpression of SCYL2
     adenovirus for overexpression of SCYL2
     LSBio Antibodies in human, mouse, rat for SCYL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SCYL2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4