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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCYL1 Gene

protein-coding   GIFtS: 53
GCID: GC11P065292

SCY1-like 1 (S. cerevisiae)

(Previous name: N-terminal kinase-like )
(Previous symbol: NTKL)
 Explore 19 diseases affiliated with
SCYL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SCYL1    

Aliases
for SCYL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SCY1-Like 1 (S. Cerevisiae)1 2     Telomerase Transcriptional Element-Interacting Factor2 3
NTKL1 2 3 5     Teratoma-Associated Tyrosine Kinase2 3
GKLP1 2 3     SCY1-Like Protein 12 3
TAPK1 2 3     HT0191
TEIF1 2 3     MGC784541
TRAP1 2 3     N-Terminal Kinase-Like1
NKTL1 2     Likely Ortholog Of Mouse N-Terminal Kinase-Like Protein2
P1051 2     N-Terminal Kinase-Like Protein2
Coated Vesicle-Associated Kinase Of 90 KDa2 3     Telomerase Transcriptional Elements-Interacting Factor2
Telomerase Regulation-Associated Protein2 3     CVAK903

External Ids:    HGNC: 143721   Entrez Gene: 574102   Ensembl: ENSG000001421867   OMIM: 6079825   UniProtKB: Q96KG93   

Export aliases for SCYL1 gene to outside databases

Previous GC identifers: GC11P066974 GC11P065542 GC11P065068 GC11P065069 GC11P065049 GC11P061619


Summaries
for SCYL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SCYL1:
This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein
has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA
sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA
polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during
mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: NTKL_HUMAN, Q96KG9
Function: Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro
Function: Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites
(box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region

Gene Wiki entry for SCYL1


Genomic Views
for SCYL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCYL1 gene promoter:
         ER-alpha   Pax-5   NF-kappaB   Meis-1b   Arnt   E47   c-Ets-1   NF-kappaB2   c-Myb   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCYL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCYL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCYL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q11-q12

SCYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCYL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P065292:  view genomic region     (about GC identifiers)

Start:
 65,292,548 bp from pter      End:
 65,306,182 bp from pter
Size:
 13,635 bases      Orientation:
 plus strand

Proteins
for SCYL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NTKL_HUMAN, Q96KG9 (See protein sequence)
Recommended Name: N-terminal kinase-like protein  
Size: 808 amino acids; 89631 Da
Subunit: Interacts with GORAB. Interacts with COPA, COPB1 and COPB2 (By similarity). Homooligomer. Interacts with AP2B1
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi
apparatus, cis-Golgi network. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an
ARF1-independent manner
Subcellular location: Isoform 1: Cytoplasm. Note=Cytoplasmic throughout the cell cycle
Subcellular location: Isoform 2: Cytoplasm. Note=Cytoplasmic throughout the cell cycle
Subcellular location: Isoform 3: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic during interphase and
centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner
Subcellular location: Isoform 6: Nucleus
Sequence caution: Sequence=AAG09726.1; Type=Frameshift; Positions=289, 307; Sequence=AAG17902.1; Type=Frameshift;
Positions=Several;
Secondary accessions: A6NJF1 Q96G50 Q96KG8 Q96KH1 Q9HAW5 Q9HBL3 Q9NR53
Alternative splicing: 6 isoforms:  Q96KG9-1   Q96KG9-2   Q96KG9-3   Q96KG9-4   Q96KG9-5   Q96KG9-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCYL1: NX_Q96KG9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96KG9

    • SCYL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001041683.1  NP_065731.3  

    ENSEMBL proteins: 
     ENSP00000270176   ENSP00000431635   ENSP00000408192   ENSP00000437254   ENSP00000433450  
     ENSP00000432175   ENSP00000436993   ENSP00000431664   ENSP00000433604   ENSP00000279270  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): SCYL1
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    Novus Biologicals SCYL1 Protein
    Novus Biologicals SCYL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SCYL1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ISS12783284
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA18556652
    GO:0005794Golgi apparatus IDA18556652
    GO:0005801cis-Golgi network IDA18556652


    SCYL1 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for SCYL1

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    Uscn ELISAs and CLIAs for SCYL1

    Protein Domains /
    Families
    for SCYL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SCYL1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011989 ARM-like
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q96KG9

    ProtoNet protein and cluster: Q96KG9

    1 Blocks protein family: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: NTKL_HUMAN, Q96KG9
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 3 HEAT repeats
    Similarity: Contains 1 protein kinase domain


    Function
    for SCYL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NTKL_HUMAN, Q96KG9
    Function: Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro
    Function: Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites
    (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region

    miRNA
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    hsa-let-7b (MIRT001596)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCYL1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SCYL1:
    hsa-miR-338-5p hsa-miR-493* hsa-let-7g* hsa-miR-3920 hsa-miR-29a* hsa-miR-3121-3p hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmid: SCYL1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCYL1 (see all 4)
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    Search LifeMap BioReagents cell lines for SCYL1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity NAS10843802
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--


    SCYL1 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for SCYL1:
     Decreased substrate adherent c  Decreased viability  Decreased viability with cispl  Increased number of small and  
     Paclitaxel antagonistic effect 

    Animal Models:
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Scyl1):
     behavior/neurological  growth/size  muscle  nervous system  reproductive system 
     skeleton  vision/eye 

    SCYL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SCYL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCYL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/69 Interacting proteins for SCYL1 (Q96KG92, 3 ENSP000002701764) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384322, 3, ENSP000002403164MINT-2875116 MINT-2875097 I2D: score=3 STRING: ENSP00000240316
    XPO7Q9UIA93, ENSP000004048534I2D: score=5 STRING: ENSP00000404853
    CD93Q9NPY33, ENSP000002460064I2D: score=2 STRING: ENSP00000246006
    ARCN1P484443, ENSP000002640284I2D: score=1 STRING: ENSP00000264028
    GORABQ5T7V83, ENSP000003567374I2D: score=3 STRING: ENSP00000356737
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER IDA18556652


    SCYL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SCYL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCYL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCYL1
    2 Novoseek chemical compound relationships for SCYL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 63.3 44 7594554 (3), 9849886 (2), 9850163 (2), 8871662 (1) (see all 35)
    phosphatidylinositol 5.16 3 7628435 (1)

    Search CenterWatch for drugs/clinical trials and news about SCYL1 / NTKL 

    Transcripts
    for SCYL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SCYL1 gene (2 alternative transcripts): 
    NM_001048218.1  NM_020680.3  

    Unigene Cluster for SCYL1:

    SCY1-like 1 (S. cerevisiae)
    Hs.238839  [show with all ESTs]
    Unigene Representative Sequence: NM_020680
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270176(uc001oea.1 uc001oeb.1 uc001oec.1 uc001oee.1)
    ENST00000525364 ENST00000420247 ENST00000533862 ENST00000527630 ENST00000524944(uc009yqk.3)
    ENST00000527009 ENST00000529178 ENST00000531601 ENST00000524897 ENST00000526454
    ENST00000529981 ENST00000528545 ENST00000534462 ENST00000532290 ENST00000279270


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCYL1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SCYL1:
    hsa-miR-338-5p hsa-miR-493* hsa-let-7g* hsa-miR-3920 hsa-miR-29a* hsa-miR-3121-3p hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmid: SCYL1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCYL1 (see all 7)
    OriGene shRNA RFP: SCYL1
    OriGene siRNA: SCYL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCYL1
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SCYL1 (NM_001048218)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCYL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCYL1

    Additional cDNA sequence: 

    AB047077.1 AB051427.1 AB051428.1 AF225424.1 AF297709.1 AK302198.1 AK314945.1 BC009967.2 
    BC069233.1 

    24/25 DOTS entries (see all 25):

    DT.99968616  DT.40132208  DT.91768216  DT.95207538  DT.100045000  DT.95375691  DT.100045002  DT.95375685 
    DT.100827674  DT.95375704  DT.100045006  DT.209761  DT.91768243  DT.100827678  DT.100827685  DT.100726045 
    DT.120708848  DT.120708866  DT.426673  DT.95375689  DT.95375698  DT.99940699  DT.448809  DT.91910742 

    24/394 AceView cDNA sequences (see all 394):

    BQ049794 BF899424 CD108294 BQ684205 BQ684161 AW204083 BQ678633 AB047077 
    BQ948957 AI092923 BI869629 BX363282 BE773986 BU628064 AI066644 T77352 
    BP365871 BF980954 BQ682855 AA336193 BC069233 BE304404 BG574553 BM791446 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SCYL1 (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a ·
    SP1:                                                                                                                                                        -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 15b · 15c ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for SCYL1

    Expression
    for SCYL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCYL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAGCCCGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SCYL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCYL1

    SOURCE GeneReport for Unigene cluster: Hs.238839

    UniProtKB/Swiss-Prot: NTKL_HUMAN, Q96KG9
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:     
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    Orthologs
    for SCYL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SCYL1 gene from 6/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.22402 Xenopus laevis transcribed sequence with weak similarity more 76.69(n)    BX844762.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wu:fk36e111 wu:fk36e11 66.28(n)
    70.33(a)    		   793792  XM_001332472.2  XP_001332508.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta yata1 CG1973-PA 56.3(n)
    51.73(a)    		   43508  NM_143465.1  NP_651722.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea W07G4.31 Protein W07G4.3 45.8(n)
    39.73(a)    		   179789  NM_073858.3  NP_506259.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G407301 SCY1-like protein 45.87(n)
    36.22(a)    		   818668  NM_129635.4  NP_181605.2 
    rice
    (Oryza sativa)    		 Liliopsida Os01g08199001 hypothetical protein 45.66(n)
    36.3(a)    		   4327606  NM_001051179.1  NP_001044644.1 


    ENSEMBL Gene Tree for SCYL1 (if available)
    TreeFam Gene Tree for SCYL1 (if available) 

    Paralogs
    for SCYL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCYL1 gene
    SCYL32  

    SCYL1 for paralogs           About GeneDecksing



    Genomic Variants
    for SCYL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/211 NCBI SNPs in SCYL1 are shown (see all 211)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1837839131,2
    		--65290579(+) CTGCCC/TGAGAA 2 -- us2k10--------
    rs1470364151,2
    		--65290593(+) CTGGGC/TATTGT 2 -- us2k10--------
    rs1476850391,2
    		--65290604(+) CTCCCC/TGACTG 2 -- us2k10--------
    rs1410034861,2
    		--65290661(+) CCCAGC/GCCGAC 2 -- us2k10--------
    rs11941011,2
    		C,--65290682(-) cagcaC/Gagacc 2 -- us2k14Minor allele frequency- G:0.05NA WA 124
    rs1143176121,2
    		--65290808(+) TGAGAT/CAGGAG 2 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1502272961,2
    		--65290935(+) GGGCAA/CAGTAC 2 -- us2k10--------
    rs1171494101,2
    		--65291042(+) GCAGAG/AATAGT 2 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1149154981,2
    		F,--65291093(+) AGCGCC/TGGTGC 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs785379281,2
    		C--65291122(+) AGTGCC/TGGTCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SCYL1 (65292548 - 65306182 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SCYL1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCYL1
    DNA2.0 Custom Variant and Variant Library Synthesis for SCYL1

    Disorders / Diseases
    for SCYL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SCYL1 for disorders           About GeneDecksing

    OMIM gene information: 607982    OMIM disorders: --

    19 diseases for SCYL1:    About MalaCards
    teratoma    silver-russell syndrome    dna topoisomerase i    monocytic leukemia
    ulcerative colitis    multiple myeloma    schistosomiasis    breast cancer
    myeloma    cervical cancer    cervicitis    neurodegeneration
    nasopharyngitis    colorectal cancer    ataxia    leukemia
    carcinoma    malaria    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SCYL1:
    Lymphoma

    4 Novoseek disease relationships for SCYL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 22 12 12947558 (3), 19958622 (3), 19272297 (1), 19198626 (1)
    cancer 9.64 8 12947558 (4), 19198626 (2), 19958622 (1)
    breast cancer 0 1 10493971 (1)
    carcinoma 0 5 15781263 (1), 19272297 (1), 19958622 (1)


    Export disorders for SCYL1 gene to outside databases

    Publications
    for SCYL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCYL1 gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with SCYL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcriptional upregulation of DNA polymerase beta by TEIF. (PubMed id 15963946)1, 2, 9 Zhao Y.... Zhang B. (2005)
    2. Molecular cloning and characterization of a human gene involved in transcriptional regulation of hTERT. (PubMed id 15504359)1, 2, 9 Tang Z.... Zhang B. (2004)
    3. Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic. (PubMed id 18556652)1, 2 Burman J.L.... McPherson P.S. (2008)
    4. Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. (PubMed id 16903783)1, 2 Schmid E.M....McMahon H.T. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Identification and characterization of the human protein kinase-like gene NTKL: mitosis-specific centrosomal localization of an alternatively spliced isoform. (PubMed id 12036289)1, 2 Kato M.... Miki Y. (2002)
    8. Construction of a 350-kb sequence-ready 11q13 cosmid contig encompassing the markers D11S4933 and D11S546: mapping of 11 genes and 3 tumor-associated translocation breakpoints. (PubMed id 10843802)1, 2 van Asseldonk M....Geurts van Kessel A. (2000)
    9. Cloning and preliminary characterization of a 105 kDa protein with an N-terminal kinase-like domain. (PubMed id 11118629)1, 3 Liu S.C....Lienhard G.E. (2000)
    10. [Expression of TEIF protein in colorectal tumors and its correlation with centrosome abnormality] (PubMed id 19958622)1, 9 Gao Y. and Zhang B. (2009)

    External Searches for SCYL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SCYL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57410 HGNC: 14372 AceView: SCYL1 Ensembl:ENSG00000142186 euGenes: HUgn57410
    ECgene: SCYL1 H-InvDB: SCYL1

    Other Databases showing SCYL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SCYL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCYL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SCYL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SCYL1 gene:
    Search GeneIP for patents involving SCYL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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