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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCYL1 Gene

protein-coding   GIFtS: 55
GCID: GC11P065292

SCY1-Like 1 (S. Cerevisiae)

(Previous name: N-terminal kinase-like)
(Previous symbol: NTKL)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SCY1-Like 1 (S. Cerevisiae)1 2     TEIF2 3
NTKL1 2 3 5     TRAP2 3
Telomerase Regulation-Associated Protein1 2 3     SCY1-Like Protein 12 3
Teratoma-Associated Tyrosine Kinase1 2 3     N-Terminal Kinase-Like1
Telomerase Transcriptional Elements-Interacting Factor1 2     NKTL2
Coated Vesicle-Associated Kinase Of 90 KDa2 3     P1052
Telomerase Transcriptional Element-Interacting Factor2 3     Likely Ortholog Of Mouse N-Terminal Kinase-Like Protein2
GKLP2 3     N-Terminal Kinase-Like Protein2
TAPK2 3     CVAK903

External Ids:    HGNC: 143721   Entrez Gene: 574102   Ensembl: ENSG000001421867   OMIM: 6079825   UniProtKB: Q96KG93   

Export aliases for SCYL1 gene to outside databases

Previous GC identifers: GC11P066974 GC11P065542 GC11P065068 GC11P065069 GC11P065049 GC11P061619


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCYL1 Gene:
This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The
protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind
specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse
transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the
cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SCYL1 Gene: 
SCYL1 (SCY1-like 1 (S. cerevisiae)) is a protein-coding gene. Diseases associated with SCYL1 include teratoma, and silver-russell syndrome. GO annotations related to this gene include protein tyrosine kinase activity and ATP binding. An important paralog of this gene is SCYL3.

UniProtKB/Swiss-Prot: NTKL_HUMAN, Q96KG9
Function: Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro
Function: Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding
sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region

Gene Wiki entry for SCYL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCYL1 gene promoter:
         ER-alpha   Pax-5   NF-kappaB   Meis-1b   Arnt   E47   c-Ets-1   NF-kappaB2   c-Myb   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCYL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCYL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCYL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q11-q12

SCYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCYL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P065292:  view genomic region     (about GC identifiers)

Start:
65,292,548 bp from pter      End:
65,306,182 bp from pter
Size:
13,635 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NTKL_HUMAN, Q96KG9 (See protein sequence)
Recommended Name: N-terminal kinase-like protein  
Size: 808 amino acids; 89631 Da
Subunit: Interacts with GORAB. Interacts with COPA, COPB1 and COPB2 (By similarity). Homooligomer. Interacts with
AP2B1
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Endoplasmic
reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Localized to the Endoplasmic
reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner
Subcellular location: Isoform 1: Cytoplasm. Note=Cytoplasmic throughout the cell cycle
Subcellular location: Isoform 2: Cytoplasm. Note=Cytoplasmic throughout the cell cycle
Subcellular location: Isoform 3: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a
microtubule-independent manner
Subcellular location: Isoform 6: Nucleus
Sequence caution: Sequence=AAG09726.1; Type=Frameshift; Positions=289, 307; Sequence=AAG17902.1; Type=Frameshift;
Positions=Several;
Secondary accessions: A6NJF1 Q96G50 Q96KG8 Q96KH1 Q9HAW5 Q9HBL3 Q9NR53
Alternative splicing: 6 isoforms:  Q96KG9-1   Q96KG9-2   Q96KG9-3   Q96KG9-4   Q96KG9-5   Q96KG9-6   (Non-canonical splice junctions)

Explore the universe of human proteins at neXtProt for SCYL1: NX_Q96KG9

Explore proteomics data for SCYL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96KG9

  • SCYL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SCYL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001041683.1  NP_065731.3  

    ENSEMBL proteins: 
     ENSP00000270176   ENSP00000431635   ENSP00000408192   ENSP00000437254   ENSP00000433450  
     ENSP00000432175   ENSP00000436993   ENSP00000431664   ENSP00000433604   ENSP00000279270  

    Human Recombinant Protein Products for SCYL1: 
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    OriGene Protein Over-expression Lysate for SCYL1
    OriGene MassSpec for SCYL1 
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    GenScript Custom Purified and Recombinant Proteins Services for SCYL1
    Novus Biologicals SCYL1 Protein
    Novus Biologicals SCYL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ISS12783284
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA18556652
    GO:0005794Golgi apparatus IDA18556652
    GO:0005801cis-Golgi network IDA18556652

    SCYL1 for ontologies           About GeneDecksing



    SCYL1 Antibody Products: 
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    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp. 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: SCY1-like 1 (S. cerevisiae) 
    SCY1 family

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q96KG9

    ProtoNet protein and cluster: Q96KG9

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: NTKL_HUMAN, Q96KG9
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 3 HEAT repeats
    Similarity: Contains 1 protein kinase domain


    SCYL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTKL_HUMAN, Q96KG9
    Function: Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro
    Function: Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding
    sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity NAS10843802
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    SCYL1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SCYL1:
     Decreased substrate adherent c  Decreased viability  Decreased viability with cispl  Increased number of small and  
     Paclitaxel antagonistic effect 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Scyl1):
     behavior/neurological  cardiovascular system  growth/size  hematopoietic system  immune system 
     mortality/aging  muscle  nervous system  reproductive system  skeleton 
     vision/eye 

    SCYL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Scyl1tm1.1Spel for SCYL1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SCYL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCYL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCYL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCYL1 

    miRNA
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    miRTarBase miRNAs that target SCYL1:
    hsa-let-7b (MIRT001596)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCYL1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SCYL1:
    hsa-miR-338-5p hsa-miR-493* hsa-let-7g* hsa-miR-3920 hsa-miR-29a* hsa-miR-3121-3p hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidSCYL1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    Sirion Biotech Customized lentivirus for stable overexpression of SCYL1 
                         Customized lentivirus expression plasmids for stable overexpression of SCYL1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCYL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/69 Interacting proteins for SCYL1 (Q96KG92, 3 ENSP000002701764) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384322, 3, ENSP000002403164MINT-2875116 MINT-2875097 I2D: score=3 STRING: ENSP00000240316
    XPO7Q9UIA93, ENSP000004048534I2D: score=5 STRING: ENSP00000404853
    CD93Q9NPY33, ENSP000002460064I2D: score=2 STRING: ENSP00000246006
    ARCN1P484443, ENSP000002640284I2D: score=1 STRING: ENSP00000264028
    GORABQ5T7V83, ENSP000003567374I2D: score=3 STRING: ENSP00000356737
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006468protein phosphorylation ----
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER IDA18556652

    SCYL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCYL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCYL1 (NTKL)

    2 Novoseek inferred chemical compound relationships for SCYL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 63.3 44 7594554 (3), 9849886 (2), 9850163 (2), 8871662 (1) (see all 35)
    phosphatidylinositol 5.16 3 7628435 (1)

    Search CenterWatch for drugs/clinical trials and news about SCYL1 / NTKL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SCYL1 gene (2 alternative transcripts): 
    NM_001048218.1  NM_020680.3  

    Unigene Cluster for SCYL1:

    SCY1-like 1 (S. cerevisiae)
    Hs.238839  [show with all ESTs]
    Unigene Representative Sequence: NM_020680
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270176(uc001oea.1 uc001oeb.1 uc001oec.1 uc001oee.1)
    ENST00000525364 ENST00000420247 ENST00000533862 ENST00000527630 ENST00000524944(uc009yqk.3)
    ENST00000527009 ENST00000529178 ENST00000531601 ENST00000524897 ENST00000526454
    ENST00000529981 ENST00000528545 ENST00000534462 ENST00000532290 ENST00000279270


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCYL1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SCYL1:
    hsa-miR-338-5p hsa-miR-493* hsa-let-7g* hsa-miR-3920 hsa-miR-29a* hsa-miR-3121-3p hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidSCYL1 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCYL1
    Clone
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    OriGene clones in human, mouse for SCYL1 (see all 12)
    OriGene ORF clones in mouse, rat for SCYL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SCYL1 (NM_001048218)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCYL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCYL1
    Sirion Biotech Customized lentivirus for stable overexpression of SCYL1 
                         Customized lentivirus expression plasmids for stable overexpression of SCYL1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCYL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCYL1

    Additional mRNA sequence: 

    AB047077.1 AB051427.1 AB051428.1 AF225424.1 AF297709.1 AK302198.1 AK314945.1 BC009967.2 
    BC069233.1 

    24/25 DOTS entries (see all 25):

    DT.99968616  DT.40132208  DT.91768216  DT.95207538  DT.100045000  DT.95375691  DT.100045002  DT.95375685 
    DT.100827674  DT.95375704  DT.100045006  DT.209761  DT.91768243  DT.100827678  DT.100827685  DT.100726045 
    DT.120708848  DT.120708866  DT.426673  DT.95375689  DT.95375698  DT.99940699  DT.448809  DT.91910742 

    24/394 AceView cDNA sequences (see all 394):

    BU196081 BU162427 AI479338 CD108294 F09634 BX334536 BM743636 BQ638058 
    BM711418 BQ679569 BU174719 BE673571 AB051427 AI470405 BQ890211 BE247155 
    BQ684205 AB051428 BG574553 BI869629 BQ049794 BE304404 AW250847 BE018462 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SCYL1 (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a ·
    SP1:                                                                                                                                                        -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 15b · 15c ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for SCYL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCYL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGCCCGGC
    SCYL1 Expression
    About this image


    See SCYL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCYL1

    SOURCE GeneReport for Unigene cluster: Hs.238839

    UniProtKB/Swiss-Prot: NTKL_HUMAN, Q96KG9
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for SCYL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCYL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SCYL1 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scyl11 , 5 SCY1-like 1 (S. cerevisiae)1, 5 87.63(n)1
    92.12(a)1
      19 (4.34 cM)5
    788911  NM_023912.21  NP_076401.11 
     57584275 
    lizard
    (Anolis carolinensis)
    Reptilia SCYL16
    Uncharacterized protein
    53(a)
    1 ↔ 1
    GL343717.1(228284-235164)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.22402 Xenopus laevis transcribed sequence with weak similarity more 76.69(n)    BX844762.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wu:fk36e111 wu:fk36e11 66.28(n)
    70.33(a)
      793792  XM_001332472.2  XP_001332508.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta yata1 CG1973-PA 56.3(n)
    51.73(a)
      43508  NM_143465.1  NP_651722.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W07G4.31 Protein W07G4.3 45.8(n)
    39.73(a)
      179789  NM_073858.3  NP_506259.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CEX1(YOR112W)4 Cytoplasmic component of the nuclear aminoacylation-dependent more   --   15(531508-533793) 854279  NP_014755.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G407301 SCY1-like protein 45.87(n)
    36.22(a)
      818668  NM_129635.4  NP_181605.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g08199001 hypothetical protein 45.66(n)
    36.3(a)
      4327606  NM_001051179.1  NP_001044644.1 


    ENSEMBL Gene Tree for SCYL1 (if available)
    TreeFam Gene Tree for SCYL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCYL1 gene
    SCYL32  

    SCYL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/333 SNPs in SCYL1 are shown (see all 333)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413654
    A metastatic melanoma sample4--see VAR_0413652 H Y mis40--------
    VAR_0413674
    ----see VAR_0413672 W S mis40--------
    rs1915205171,2
    --61617576(+) CCAGGA/GACATG 2 -- us2k10--------
    rs1837839131,2
    --65290579(+) CTGCCC/TGAGAA 2 -- us2k10--------
    rs1470364151,2
    --65290593(+) CTGGGC/TATTGT 2 -- us2k10--------
    rs1476850391,2
    --65290604(+) CTCCCC/TGACTG 2 -- us2k10--------
    rs1410034861,2
    --65290661(+) CCCAGC/GCCGAC 2 -- us2k10--------
    rs11941011,2
    C,F--65290682(-) cagcaC/Gagacc 2 -- us2k14Minor allele frequency- G:0.05NA WA 124
    rs1143176121,2
    F--65290808(+) TGAGAT/CAGGAG 2 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1502272961,2
    --65290935(+) GGGCAA/CAGTAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SCYL1 (65292548 - 65306182 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for SCYL1 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671903CNV Deletion23128226
    nsv361CNV Insertion18451855
    dgv1178n71CNV Loss21882294
    nsv897723CNV Loss21882294
    dgv1175n71CNV Loss21882294
    nsv897730CNV Loss21882294
    dgv1176n71CNV Loss21882294
    dgv1177n71CNV Loss21882294
    nsv897719CNV Loss21882294
    nsv897718CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607982    OMIM disorders: --

    15 diseases for SCYL1:    About MalaCards
    teratoma    silver-russell syndrome    schistosomiasis    ulcerative colitis
    monocytic leukemia    nasopharyngitis    multiple myeloma    myeloma
    cervical cancer    cervicitis    breast cancer    colorectal cancer
    hepatocellular carcinoma    leukemia    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SCYL1:
    Lymphoma

    SCYL1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for SCYL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 22 12 12947558 (3), 19958622 (3), 19272297 (1), 19198626 (1)
    cancer 9.64 8 12947558 (4), 19198626 (2), 19958622 (1)
    breast cancer 0 1 10493971 (1)
    carcinoma 0 5 15781263 (1), 19272297 (1), 19958622 (1)


    Export disorders for SCYL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCYL1 gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with SCYL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcriptional upregulation of DNA polymerase beta by TEIF. (PubMed id 15963946)1, 2, 9 Zhao Y.... Zhang B. (2005)
    2. Molecular cloning and characterization of a human gene involved in transcriptional regulation of hTERT. (PubMed id 15504359)1, 2, 9 Tang Z.... Zhang B. (2004)
    3. Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic. (PubMed id 18556652)1, 2 Burman J.L.... McPherson P.S. (2008)
    4. Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. (PubMed id 16903783)1, 2 Schmid E.M....McMahon H.T. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Identification and characterization of the human protein kinase-like gene NTKL: mitosis-specific centrosomal localization of an alternatively spliced isoform. (PubMed id 12036289)1, 2 Kato M.... Miki Y. (2002)
    8. Construction of a 350-kb sequence-ready 11q13 cosmid contig encompassing the markers D11S4933 and D11S546: mapping of 11 genes and 3 tumor-associated translocation breakpoints. (PubMed id 10843802)1, 2 van Asseldonk M....Geurts van Kessel A. (2000)
    9. Cloning and preliminary characterization of a 105 kDa protein with an N-terminal kinase-like domain. (PubMed id 11118629)1, 3 Liu S.C....Lienhard G.E. (2000)
    10. [Expression of TEIF protein in colorectal tumors and its correlation with centrosome abnormality] (PubMed id 19958622)1, 9 Gao Y. and Zhang B. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57410 HGNC: 14372 AceView: SCYL1 Ensembl:ENSG00000142186 euGenes: HUgn57410
    ECgene: SCYL1 H-InvDB: SCYL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCYL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCYL1 gene:
    Search GeneIP for patents involving SCYL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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