Aliases for SCYL1 Gene
- SCY1 Like Pseudokinase 1 2 3 5
- Telomerase Regulation-Associated Protein 2 3 4
- Teratoma-Associated Tyrosine Kinase 2 3 4
- Telomerase Transcriptional Elements-Interacting Factor 2 3
- Coated Vesicle-Associated Kinase Of 90 KDa 3 4
- SCY1-Like, Kinase-Like 1 2 3
- SCY1-Like Protein 1 3 4
- TRAP 3 4
- NTKL 3 4
- GKLP 3 4
- TAPK 3 4
- TEIF 3 4
External Ids for SCYL1 Gene
Previous HGNC Symbols for SCYL1 Gene
Previous GeneCards Identifiers for SCYL1 Gene
This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SCYL1 Gene
SCYL1 (SCY1 Like Pseudokinase 1) is a Protein Coding gene. Diseases associated with SCYL1 include Orbit Lymphoma and Excessive Tearing. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
UniProtKB/Swiss-Prot for SCYL1 Gene
Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). Has no detectable kinase activity in vitro (PubMed:18556652).
Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.