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Aliases for SCYL1 Gene

Aliases for SCYL1 Gene

  • SCY1-Like 1 (S. Cerevisiae) 2 3
  • Telomerase Regulation-Associated Protein 2 3 4
  • Teratoma-Associated Tyrosine Kinase 2 3 4
  • NTKL 3 4 6
  • Telomerase Transcriptional Elements-Interacting Factor 2 3
  • Telomerase Transcriptional Element-Interacting Factor 3 4
  • Coated Vesicle-Associated Kinase Of 90 KDa 3 4
  • SCY1-Like Protein 1 3 4
  • TRAP 3 4
  • GKLP 3 4
  • TAPK 3 4
  • TEIF 3 4
  • Likely Ortholog Of Mouse N-Terminal Kinase-Like Protein 3
  • N-Terminal Kinase-Like Protein 3
  • N-Terminal Kinase-Like 2
  • CVAK90 4
  • HT019 3
  • P105 3
  • NKTL 3

External Ids for SCYL1 Gene

Previous Symbols for SCYL1 Gene

  • NTKL

Summaries for SCYL1 Gene

Entrez Gene Summary for SCYL1 Gene

  • This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCYL1 Gene

SCYL1 (SCY1-Like 1 (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for SCYL1 Gene

  • Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro.

  • Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.

Gene Wiki entry for SCYL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCYL1 Gene

Genomics for SCYL1 Gene

Genomic Location for SCYL1 Gene

Start:
65,525,066 bp from pter
End:
65,538,711 bp from pter
Size:
13,646 bases
Orientation:
Plus strand

Genomic View for SCYL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCYL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCYL1 Gene

Regulatory Elements for SCYL1 Gene

Proteins for SCYL1 Gene

  • Protein details for SCYL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KG9-NTKL_HUMAN
    Recommended name:
    N-terminal kinase-like protein
    Protein Accession:
    Q96KG9
    Secondary Accessions:
    • A6NJF1
    • Q96G50
    • Q96KG8
    • Q96KH1
    • Q9HAW5
    • Q9HBL3
    • Q9NR53

    Protein attributes for SCYL1 Gene

    Size:
    808 amino acids
    Molecular mass:
    89631 Da
    Quaternary structure:
    • Interacts with GORAB. Interacts with COPA, COPB1 and COPB2 (By similarity). Homooligomer. Interacts with AP2B1.
    SequenceCaution:
    • Sequence=AAG09726.1; Type=Frameshift; Positions=289, 307; Evidence={ECO:0000305}; Sequence=AAG17902.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for SCYL1 Gene

neXtProt entry for SCYL1 Gene

Proteomics data for SCYL1 Gene at MOPED

Post-translational modifications for SCYL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCYL1 Gene

Domains for SCYL1 Gene

Gene Families for SCYL1 Gene

Protein Domains for SCYL1 Gene

UniProtKB/Swiss-Prot:

NTKL_HUMAN
Domain:
  • The protein kinase domain is predicted to be catalytically inactive:
    • Q96KG9
  • Contains 1 protein kinase domain.:
    • Q96KG9
Family:
  • Belongs to the protein kinase superfamily.:
    • Q96KG9
Similarity:
  • Contains 3 HEAT repeats.:
    • Q96KG9
genes like me logo Genes that share domains with SCYL1: view

Function for SCYL1 Gene

Molecular function for SCYL1 Gene

UniProtKB/Swiss-Prot Function: Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro.
UniProtKB/Swiss-Prot Function: Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.

Gene Ontology (GO) - Molecular Function for SCYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity NAS 10843802
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SCYL1: view
genes like me logo Genes that share phenotypes with SCYL1: view

Animal Models for SCYL1 Gene

MGI Knock Outs for SCYL1:

miRNA for SCYL1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SCYL1 Gene

Localization for SCYL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCYL1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.
Isoform 1: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.
Isoform 2: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.
Isoform 3: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.
Isoform 6: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCYL1 Gene COMPARTMENTS Subcellular localization image for SCYL1 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SCYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm ISS 12783284
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 18556652
GO:0005794 Golgi apparatus IDA 18556652
GO:0005801 cis-Golgi network IDA 18556652
genes like me logo Genes that share ontologies with SCYL1: view

Pathways for SCYL1 Gene

SuperPathways for SCYL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IDA 18556652
GO:0018108 peptidyl-tyrosine phosphorylation NAS 10843802
genes like me logo Genes that share ontologies with SCYL1: view

No data available for Pathways by source for SCYL1 Gene

Compounds for SCYL1 Gene

(2) Novoseek inferred chemical compound relationships for SCYL1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 63.3 39
phosphatidylinositol 5.16 1
genes like me logo Genes that share compounds with SCYL1: view

Transcripts for SCYL1 Gene

Unigene Clusters for SCYL1 Gene

SCY1-like 1 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCYL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

ExUns: 15b · 15c ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SCYL1 Gene

GeneLoc Exon Structure for
SCYL1
ECgene alternative splicing isoforms for
SCYL1

Expression for SCYL1 Gene

mRNA expression in normal human tissues for SCYL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCYL1 Gene

SOURCE GeneReport for Unigene cluster for SCYL1 Gene Hs.238839

mRNA Expression by UniProt/SwissProt for SCYL1 Gene

Q96KG9-NTKL_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with SCYL1: view

Orthologs for SCYL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCYL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCYL1 36
  • 99.41 (n)
  • 99.24 (a)
SCYL1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCYL1 36
  • 89.17 (n)
  • 92.26 (a)
SCYL1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCYL1 36
  • 90.24 (n)
  • 93.91 (a)
SCYL1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scyl1 36
  • 87.63 (n)
  • 92.12 (a)
Scyl1 16
Scyl1 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCYL1 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCYL1 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scyl1 36
  • 87.39 (n)
  • 91.62 (a)
lizard
(Anolis carolinensis)
Reptilia SCYL1 37
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2240 36
tropical clawed frog
(Silurana tropicalis)
Amphibia scyl1 36
  • 67.91 (n)
  • 70.66 (a)
Str.394 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2322 36
zebrafish
(Danio rerio)
Actinopterygii SCYL1 (1 of 2) 37
  • 64 (a)
OneToMany
SCYL1 (2 of 2) 37
  • 64 (a)
OneToMany
wu:fk36e11 36
  • 66.33 (n)
  • 70.33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001091 36
  • 52.35 (n)
  • 51.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta yata 36
  • 56.78 (n)
  • 52.62 (a)
yata 37
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea W07G4.3 36
  • 46.71 (n)
  • 41.79 (a)
W07G4.3 37
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CEX1 37
  • 20 (a)
OneToOne
CEX1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40730 36
  • 48.31 (n)
  • 40.34 (a)
rice
(Oryza sativa)
Liliopsida Os01g0819900 36
  • 50.22 (n)
  • 42.58 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04279 36
  • 49.35 (n)
  • 36.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5507 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToOne
Species with no ortholog for SCYL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCYL1 Gene

ENSEMBL:
Gene Tree for SCYL1 (if available)
TreeFam:
Gene Tree for SCYL1 (if available)

Paralogs for SCYL1 Gene

No data available for Paralogs for SCYL1 Gene

Variants for SCYL1 Gene

Sequence variations from dbSNP and Humsavar for SCYL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs602922 -- 65,530,129(-) GGGAA(A/G)GCAAG intron-variant
rs684686 -- 65,531,391(-) CTGGG(A/C)CAAGG intron-variant
rs947791 -- 65,535,422(-) TCCTG(C/T)GACAG intron-variant
rs947792 -- 65,530,006(-) CCCCC(A/G)ATTCA intron-variant
rs1143756 -- 65,532,124(+) CCCTC(A/G)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCYL1 Gene

Variant ID Type Subtype PubMed ID
dgv1175n71 CNV Loss 21882294
nsv897718 CNV Loss 21882294
nsv897719 CNV Loss 21882294
nsv897720 CNV Loss 21882294
dgv1176n71 CNV Loss 21882294
nsv361 CNV Insertion 18451855
nsv897723 CNV Loss 21882294
dgv1177n71 CNV Loss 21882294
dgv1178n71 CNV Loss 21882294
nsv897730 CNV Loss 21882294
esv2671903 CNV Deletion 23128226

Relevant External Links for SCYL1 Gene

HapMap Linkage Disequilibrium report
SCYL1

Disorders for SCYL1 Gene

(1) University of Copenhagen DISEASES for SCYL1 Gene

(4) Novoseek inferred disease relationships for SCYL1 Gene

Disease -log(P) Hits PubMed IDs
tumors 22 8
cancer 9.64 7
breast cancer 0 1
carcinoma 0 3
genes like me logo Genes that share disorders with SCYL1: view

No data available for UniProtKB/Swiss-Prot for SCYL1 Gene

Publications for SCYL1 Gene

  1. Transcriptional upregulation of DNA polymerase beta by TEIF. (PMID: 15963946) Zhao Y. … Zhang B. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  2. Molecular cloning and characterization of a human gene involved in transcriptional regulation of hTERT. (PMID: 15504359) Tang Z. … Zhang B. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  3. [Expression of TEIF protein in colorectal tumors and its correlation with centrosome abnormality]. (PMID: 19958622) Gao Y. … Zhang B. (Ai Zheng 2009) 3 23
  4. Localization of TEIF in the centrosome and its functional association with centrosome amplification in DNA damage, telomere dysfunction and human cancers. (PMID: 19198626) Gong Y. … Zhang B. (Oncogene 2009) 3 23
  5. Cloning and preliminary characterization of a 105 kDa protein with an N-terminal kinase-like domain. (PMID: 11118629) Liu S.C. … Lienhard G.E. (Biochim. Biophys. Acta 2000) 2 3

Products for SCYL1 Gene

  • Addgene plasmids for SCYL1

Sources for SCYL1 Gene

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