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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCXA Gene

protein-coding   GIFtS: 38
GCID: GC08P145490

scleraxis homolog A (mouse)
 Explore 6 diseases affiliated with
SCXA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SCXA    

Aliases
for SCXA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Scleraxis Homolog A (Mouse)1 2     Basic Helix-Loop-Helix Transcription Factor Scleraxis2
BHLHa411     Class II BHLH Protein Scleraxis2
SCX2 3 5     BHLHA413
Class A Basic Helix-Loop-Helix Protein 412 3     BHLHA483
Class A Basic Helix-Loop-Helix Protein 482 3     BHLHa481

External Ids:    HGNC: 243121   Entrez Gene: 1001298852   Ensembl: ENSG000001886867   OMIM: 6090675   UniProtKB: Q7RTU73   

Export aliases for SCXA gene to outside databases

Previous GC identifers: GC08U900612 GC08P145394 GC08P145462 GC08P145398 GC08P145463 GC08P145464


Summaries
for SCXA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SCX_HUMAN, Q7RTU7
Function: Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived
chondrogenic lineages (By similarity)




Genomic Views
for SCXA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_037704.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCXA gene promoter:
         Max1   STAT5B   NF-1   Spz1   Pax-5   Sp1   Lmo2   Nkx2-5   GATA-2   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SCXA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCXA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

SCXA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCXA gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P145490:  view genomic region     (about GC identifiers)

Start:
 145,490,549 bp from pter      End:
 145,492,470 bp from pter
Size:
 1,922 bases      Orientation:
 plus strand

Proteins
for SCXA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SCX_HUMAN, Q7RTU7 (See protein sequence)
Recommended Name: Basic helix-loop-helix transcription factor scleraxis  
Size: 201 amino acids; 21596 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Dimerizes and binds the E-box consensus
sequence with E12 (By similarity)
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for SCXA: NX_Q7RTU7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7RTU7

    • SCXA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001008272.1  
    ENSEMBL proteins: 
     ENSP00000345599  

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    Uscn Proteins for SCXA

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10775504
    GO:0005667transcription factor complex IDA10775504


    SCXA for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SCXA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SCXA for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q7RTU7

    ProtoNet protein and cluster: Q7RTU7

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: SCX_HUMAN, Q7RTU7
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for SCXA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SCX_HUMAN, Q7RTU7
    Function: Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived
    chondrogenic lineages (By similarity)

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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0005515protein binding ----
    GO:0043425bHLH transcription factor binding IPI10775504
    GO:0043565sequence-specific DNA binding ISS--
    GO:0046982protein heterodimerization activity IDA10775504


    SCXA for ontologies           About GeneDecksing



    Pathways & Interactions
    for SCXA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCXA

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SCXA (Q7RTU73 ENSP000003455994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SOX9P484363, ENSP000002454794I2D: score=1 STRING: ENSP00000245479
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001707mesoderm formation ISS--
    GO:0001894tissue homeostasis ISS--
    GO:0001958endochondral ossification ISS--
    GO:0002062chondrocyte differentiation ISS--
    GO:0003179heart valve morphogenesis ISS--


    SCXA for ontologies           About GeneDecksing



    Drugs & Compounds
    for SCXA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SCXA
    Search CenterWatch for drugs/clinical trials and news about SCXA / SCX 

    Transcripts
    for SCXA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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    About This Section
    REFSEQ mRNAs for SCXA gene: 
    NM_001008271.1  

    Unigene Cluster for SCXA:

    Scleraxis homolog A (mouse)
    Hs.723088
    Unigene Representative Sequence: NM_001008271
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340695(uc003zbs.2)

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    Inhib. RNA
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    Clone
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    GeneLoc Exon Structure


    Expression
    for SCXA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCXA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SCXA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Connective tissue progenitor cells (Generation of connec...)
    Cell sheets (Stepwise differentia...)
    Mesenchymal stem cells (Stepwise differentia...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SCXA Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.723088
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    In Situ
    Assay Products:     
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    Orthologs
    for SCXA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SCXA gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SCX1 class II bHLH protein scleraxis 82(n)
    80.75(a)    		   374101  NM_204253.1  NP_989584.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 67(a)
    		 1 → many
    		 GL343752.1(215893-216489)
    zebrafish
    (Danio rerio)    		 Actinopterygii scxa1 scleraxis homolog A (mouse) 69.22(n)
    71.04(a)    		   100034489  NM_001083069.1  NP_001076538.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG335576
    		 --
    		 37(a)
    		 1 → many
    		 X(9903268-9903886)


    ENSEMBL Gene Tree for SCXA (if available)
    TreeFam Gene Tree for SCXA (if available) 

    Paralogs
    for SCXA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCXA gene
    SCXB1 2  TCF242  NHLH12  TWIST12  TWIST22  TAL12  HAND22  TCF232  
    LYL12  NHLH22  TAL22  TCF152  TCF212  HAND12  MSC2  
    6 SIMAP similar genes for SCXA using alignment to 1 protein entry:     SCX_HUMAN:
    TAL2    TCF15    HAND2    TWIST2    ATOH7    NHLH2

    SCXA for paralogs           About GeneDecksing



    Genomic Variants
    for SCXA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SCXA
         4 CNVs: 23291 31457 30305 30306
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    Disorders / Diseases
    for SCXA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SCXA for disorders           About GeneDecksing

    OMIM gene information: 609067    OMIM disorders: --

    6 diseases for SCXA:    About MalaCards
    eosinophilia-myalgia syndrome    endomyocardial fibrosis    eosinophilia    gingivitis
    periodontitis    fibrosis

    1 disease from the University of Copenhagen DISEASES database for SCXA:
    eosinophilia-myalgia syndrome

    Export disorders for SCXA gene to outside databases

    Publications
    for SCXA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCXA gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with SCXA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
    2. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 12617822)1, 2 McLellan A.S.... Kealey T. (2002)
    3. Synergistic roles of scleraxis and Smads in the regula tion of collagen 1a2 gene expression. (PubMed id 22796342)1 Bagchi R.A. and Czubryt M.P. (2012)
    4. Conversion of human bone marrow-derived mesenchymal st em cells into tendon progenitor cells by ectopic expression of scleraxis. (PubMed id 21988170)1 Alberton P....Docheva D. (2012)
    5. Host cell targets of tegument protein VP22 of herpes simplex virus 1. (PubMed id 21424732)1 Li M....Zheng C. (2011)
    6. Scleraxis and E47 cooperatively regulate the Sox9-dep endent transcription. (PubMed id 19828133)1 Furumatsu T....Ozaki T. (2010)
    7. [Effect of high glucose on the expression of transcription factor Scleraxis in periodontal ligament cells in vitro] (PubMed id 19087640)1 Yuan Y.D....Xie H. (2008)
    8. [Expression of Scleraxis in human periodontal ligamen t cells and gingival fibroblasts] (PubMed id 17129431)1 Liu Q....Li C.Z. (2006)
    9. Cultivation of human tenocytes in high-density culture. (PubMed id 15338228)1 Schulze-Tanzil G....Shakibaei M. (2004)
    10. Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property. (PubMed id 12837285)1 Salingcarnboriboon R....Noda M. (2003)

    External Searches for SCXA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SCXA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100129885 HGNC: 24312 Ensembl:ENSG00000188686 euGenes: HUgn100129885 ECgene: SCXA
    H-InvDB: SCXA

    Other Databases showing SCXA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SCXA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCXA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SCXA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SCXA gene:
    Search GeneIP for patents involving SCXA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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