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Aliases for SCX Gene

Aliases for SCX Gene

  • Scleraxis Basic Helix-Loop-Helix Transcription Factor 2 3
  • Class A Basic Helix-Loop-Helix Protein 41 3 4
  • Class A Basic Helix-Loop-Helix Protein 48 3 4
  • BHLHa48 3 4
  • SCXB 3 4
  • SCXA 3 4
  • Basic Helix-Loop-Helix Transcription Factor Scleraxis 3
  • Class II BHLH Protein Scleraxis 3
  • Scleraxis Homolog A (Mouse) 2
  • Scleraxis Homolog B (Mouse) 2
  • Scleraxis Homolog (Mouse) 2
  • Scleraxis Homolog A 3
  • Scleraxis Homolog B 3
  • BHLHA41 4
  • SCXA, 6

External Ids for SCX Gene

Previous HGNC Symbols for SCX Gene

  • SCXA
  • SCXB

Previous GeneCards Identifiers for SCX Gene

  • GC08U900014

Summaries for SCX Gene

GeneCards Summary for SCX Gene

SCX (Scleraxis Basic Helix-Loop-Helix Transcription Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SCX Gene

  • Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.

Gene Wiki entry for SCX Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCX Gene

Genomics for SCX Gene

Genomic Location for SCX Gene

144,265,078 bp from pter
144,268,483 bp from pter
3,406 bases
Plus strand

Genomic View for SCX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCX Gene

No data available for Regulatory Elements for SCX Gene

Proteins for SCX Gene

  • Protein details for SCX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Basic helix-loop-helix transcription factor scleraxis
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SCX Gene

    201 amino acids
    Molecular mass:
    21596 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Dimerizes and binds the E-box consensus sequence with E12 (By similarity).

neXtProt entry for SCX Gene

Proteomics data for SCX Gene at MOPED

Post-translational modifications for SCX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCX Gene

Domains for SCX Gene

Gene Families for SCX Gene

  • bHLH :Basic helix-loop-helix proteins

Protein Domains for SCX Gene

Graphical View of Domain Structure for InterPro Entry



  • Q7RTU7
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with SCX: view

No data available for Suggested Antigen Peptide Sequences for SCX Gene

Function for SCX Gene

Molecular function for SCX Gene

UniProtKB/Swiss-Prot Function: Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.

Gene Ontology (GO) - Molecular Function for SCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0005515 protein binding --
GO:0043425 bHLH transcription factor binding IPI 10775504
GO:0043565 sequence-specific DNA binding ISS --
GO:0046982 protein heterodimerization activity IDA 10775504
genes like me logo Genes that share ontologies with SCX: view
genes like me logo Genes that share phenotypes with SCX: view

Animal Models for SCX Gene

MGI Knock Outs for SCX:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SCX Gene

Localization for SCX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCX Gene


Gene Ontology (GO) - Cellular Components for SCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10775504
GO:0005667 transcription factor complex IDA 10775504
genes like me logo Genes that share ontologies with SCX: view

No data available for Subcellular locations from COMPARTMENTS for SCX Gene

Pathways for SCX Gene

SuperPathways for SCX Gene

No Data Available

Interacting Proteins for SCX Gene

Selected Interacting proteins: Q7RTU7-SCX_HUMAN for SCX Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001707 mesoderm formation ISS --
GO:0001894 tissue homeostasis ISS --
GO:0001958 endochondral ossification ISS --
GO:0002062 chondrocyte differentiation ISS --
GO:0003179 heart valve morphogenesis ISS --
genes like me logo Genes that share ontologies with SCX: view

No data available for Pathways by source for SCX Gene

Transcripts for SCX Gene

mRNA/cDNA for SCX Gene

(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SCX Gene

No ASD Table

Relevant External Links for SCX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCX Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SCX Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCX Gene

Orthologs for SCX Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC615157 35
  • 89.22 (n)
  • 93.03 (a)
(Canis familiaris)
Mammalia SCXA 35
  • 90.17 (n)
  • 91.5 (a)
(Mus musculus)
Mammalia Scx 35
  • 87.56 (n)
  • 94.03 (a)
Scx 16
(Rattus norvegicus)
Mammalia Scx 35
  • 87.4 (n)
  • 94.03 (a)
(Gallus gallus)
Aves SCXB 35
  • 78.97 (n)
  • 77.01 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490170 35
  • 72.68 (n)
  • 69.95 (a)
(Danio rerio)
Actinopterygii scxa 35
  • 67.03 (n)
  • 66.49 (a)
Species with no ortholog for SCX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCX Gene

Gene Tree for SCX (if available)
Gene Tree for SCX (if available)

Paralogs for SCX Gene

No data available for Paralogs for SCX Gene

Variants for SCX Gene

Relevant External Links for SCX Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for SCX Gene

Disorders for SCX Gene

No disorders were found for SCX Gene.

No data available for UniProtKB/Swiss-Prot for SCX Gene

Publications for SCX Gene

  1. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PMID: 12617822) McLellan A.S. … Kealey T. (Gene Expr. Patterns 2002) 3 4
  2. The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis. (PMID: 19362560) Espira L. … Czubryt M.P. (J. Mol. Cell. Cardiol. 2009) 2 3
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4
  4. [Expression of Scleraxis in human periodontal ligament cells and gingival fibroblasts]. (PMID: 17129431) Liu Q. … Li C.Z. (Zhonghua Kou Qiang Yi Xue Za Zhi 2006) 3
  5. [Effect of high glucose on the expression of transcription factor Scleraxis in periodontal ligament cells in vitro]. (PMID: 19087640) Yuan Y.D. … Xie H. (Zhonghua Kou Qiang Yi Xue Za Zhi 2008) 3

Products for SCX Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SCX
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SCX
    • Block miRNA regulation of SCX using miScript Target Protectors

    Sources for SCX Gene

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