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Aliases for SCX Gene

Aliases for SCX Gene

  • Scleraxis BHLH Transcription Factor 2 3 5
  • Scleraxis Basic Helix-Loop-Helix Transcription Factor 2 3
  • Class A Basic Helix-Loop-Helix Protein 41 3 4
  • Class A Basic Helix-Loop-Helix Protein 48 3 4
  • BHLHa48 3 4
  • SCXA 3 4
  • SCXB 3 4
  • Class II BHLH Protein Scleraxis 3
  • Scleraxis Homolog A (Mouse) 2
  • Scleraxis Homolog B (Mouse) 2
  • Scleraxis Homolog (Mouse) 2
  • Scleraxis Homolog A 3
  • Scleraxis Homolog B 3
  • BHLHA41 4

External Ids for SCX Gene

Previous HGNC Symbols for SCX Gene

  • SCXA
  • SCXB

Previous GeneCards Identifiers for SCX Gene

  • GC08U900014

Summaries for SCX Gene

GeneCards Summary for SCX Gene

SCX (Scleraxis BHLH Transcription Factor) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is LYL1.

UniProtKB/Swiss-Prot for SCX Gene

  • Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.

Gene Wiki entry for SCX Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCX Gene

Genomics for SCX Gene

Regulatory Elements for SCX Gene

Enhancers for SCX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCX on UCSC Golden Path with GeneCards custom track

Promoters for SCX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCX on UCSC Golden Path with GeneCards custom track

Genomic Location for SCX Gene

144,265,060 bp from pter
144,268,483 bp from pter
3,424 bases
Plus strand

Genomic View for SCX Gene

Genes around SCX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCX Gene

Proteins for SCX Gene

  • Protein details for SCX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Basic helix-loop-helix transcription factor scleraxis
    Protein Accession:

    Protein attributes for SCX Gene

    201 amino acids
    Molecular mass:
    21596 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Dimerizes and binds the E-box consensus sequence with E12 (By similarity).

neXtProt entry for SCX Gene

Proteomics data for SCX Gene at MOPED

Post-translational modifications for SCX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCX Gene

Domains & Families for SCX Gene

Gene Families for SCX Gene

Protein Domains for SCX Gene

Suggested Antigen Peptide Sequences for SCX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with SCX: view

Function for SCX Gene

Molecular function for SCX Gene

UniProtKB/Swiss-Prot Function:
Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.
genes like me logo Genes that share phenotypes with SCX: view

Animal Models for SCX Gene

MGI Knock Outs for SCX:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SCX Gene

Localization for SCX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCX Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SCX Gene

Pathways & Interactions for SCX Gene

SuperPathways for SCX Gene

No Data Available

Interacting Proteins for SCX Gene

Selected Interacting proteins: Q7RTU7-SCX_HUMAN for SCX Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001707 mesoderm formation IEA,ISS --
GO:0001894 tissue homeostasis IEA,ISS --
GO:0001958 endochondral ossification IEA,ISS --
GO:0002062 chondrocyte differentiation IEA,ISS --
GO:0003188 heart valve formation IEA,ISS --
genes like me logo Genes that share ontologies with SCX: view

No data available for Pathways by source and SIGNOR curated interactions for SCX Gene

Drugs & Compounds for SCX Gene

No Compound Related Data Available

Transcripts for SCX Gene

mRNA/cDNA for SCX Gene

(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SCX Gene

No ASD Table

Relevant External Links for SCX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCX Gene

This gene is overexpressed in Urine (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCX Gene

genes like me logo Genes that share expression patterns with SCX: view

Protein tissue co-expression partners for SCX Gene

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCX Gene

Orthologs for SCX Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC615157 35
  • 89.22 (n)
  • 93.03 (a)
(Canis familiaris)
Mammalia SCXA 35
  • 90.17 (n)
  • 91.5 (a)
(Mus musculus)
Mammalia Scx 35
  • 87.56 (n)
  • 94.03 (a)
Scx 16
(Rattus norvegicus)
Mammalia Scx 35
  • 87.4 (n)
  • 94.03 (a)
(Gallus gallus)
Aves SCXB 35
  • 78.97 (n)
  • 77.01 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490170 35
  • 72.68 (n)
  • 69.95 (a)
(Danio rerio)
Actinopterygii scxa 35
  • 67.03 (n)
  • 66.49 (a)
Species with no ortholog for SCX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCX Gene

Gene Tree for SCX (if available)
Gene Tree for SCX (if available)

Paralogs for SCX Gene

Paralogs for SCX Gene

genes like me logo Genes that share paralogs with SCX: view

Variants for SCX Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for SCX Gene

Disorders for SCX Gene

Relevant External Links for SCX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCX Gene

Publications for SCX Gene

  1. The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis. (PMID: 19362560) Espira L. … Czubryt M.P. (J. Mol. Cell. Cardiol. 2009) 2 3 67
  2. TgfI^-Smad and MAPK signaling mediate scleraxis and proteoglycan expression in heart valves. (PMID: 24157418) Barnette D.N. … Lincoln J. (J. Mol. Cell. Cardiol. 2013) 3
  3. Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis. (PMID: 21988170) Alberton P. … Docheva D. (Stem Cells Dev. 2012) 3
  4. Synergistic roles of scleraxis and Smads in the regulation of collagen 1I+2 gene expression. (PMID: 22796342) Bagchi R.A. … Czubryt M.P. (Biochim. Biophys. Acta 2012) 3
  5. Host cell targets of tegument protein VP22 of herpes simplex virus 1. (PMID: 21424732) Li M. … Zheng C. (Arch. Virol. 2011) 3

Products for SCX Gene

Sources for SCX Gene