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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SCUBE3 Gene

protein-coding GIFtS: 50
GCID: GC06P035182

signal peptide, CUB domain, EGF-like 3

(Previous name: CUB domain and EGF-like repeat containing 3 )
(Previous symbol: CEGF3)

Explore 2 diseases affiliated with
SCUBE3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Signal Peptide, CUB Domain, EGF-Like 3¹ ²		CUB And EGF Containing Protein 3²
CEGF3¹ ² ³		Signal Peptide, CUB And EGF-Like Domain Containing Protein 3²
CUB Domain And EGF-Like Repeat Containing 3¹ ²		Signal Peptide, CUB And EGF-Like Domain-Containing Protein 3²
FLJ34743¹

External Ids:	HGNC: 13655¹	Entrez Gene: 222663²	Ensembl: ENSG00000146197⁷	OMIM: 614708⁵	UniProtKB: Q8IX30³

Export aliases for SCUBE3 gene to outside databases

Previous GC identifers: GC06P035231 GC06P035290 GC06P034902

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SCUB3_HUMAN, Q8IX30

Function: Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine

and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal

transition and cancer progression

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SCUBE3 gene promoter:
oct-B2 HOXA3 FOXF2 Olf-1 E47 FOXL1 POU2F2C SRY FOXO4 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCUBE3 promoter sequence

Search SABiosciences Chromatin IP Primers for SCUBE3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCUBE3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.3

SCUBE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCUBE3 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P035182: view genomic region (about GC identifiers)

Start:	35,182,190 bp from pter	End:	35,220,856 bp from pter
Size:	38,667 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SCUB3_HUMAN, Q8IX30 (See protein sequence)

Recommended Name: Signal peptide, CUB and EGF-like domain-containing protein 3 precursor

Size: 993 amino acids; 109282 Da

Subunit: Forms homooligomers and heterooligomers with SCUBE1. Interacts with TGFBR2 through the CUB domain; this

interaction does not affect TGFB1-binding to TGFBR2

Subcellular location: Secreted. Cell surface

Sequence caution: Sequence=BAC03798.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: A8K5A3 Q5CZB3 Q86UZ9 Q8NAU9

Alternative splicing: 2 isoforms: Q8IX30-1 Q8IX30-2

Explore the universe of human proteins at neXtProt for SCUBE3: NX_Q8IX30

Post-translational modifications:

N-glycosylated¹

Proteolytic cleavage produces a CUB-containing C-terminal fragment that retains the ability to bind to TGFBR2. This

reaction is catalyzed in vitro by MMP2 and, to a lesser extent, by MMP9¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IX30

SCUBE3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689966.2

ENSEMBL proteins:

ENSP00000274938 ENSP00000378174

Human Recombinant Protein Products:

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	Novus Biologicals SCUBE3 Proteins Novus Biologicals SCUBE3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SCUBE3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0009986	cell surface	IDA	15234972

SCUBE3 for ontologies About GeneDecksing

SCUBE3 Antibody Products:

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	Uscn ELISAs and CLIAs for SCUBE3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SCUBE3 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR000859 CUB_dom

IPR011641 Tyr-kin_ephrin_A/B_rcpt-like

IPR001881 EGF-like_Ca-bd

IPR000742 EG-like_dom

IPR009030 Growth_fac_rcpt

Graphical View of Domain Structure for InterPro Entry Q8IX30

ProtoNet protein and cluster: Q8IX30

3 Blocks protein families:

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB000859 CUB domain

IPB001881 EGF-like calcium-binding

UniProtKB/Swiss-Prot: SCUB3_HUMAN, Q8IX30

Similarity: Contains 1 CUB domain

Similarity: Contains 9 EGF-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SCUB3_HUMAN, Q8IX30

Function: Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine

and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal

transition and cancer progression

miRNA Products:		OriGene 3'-UTR Clone: SCUBE3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCUBE3
		8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate SCUBE3 (see all 57):
		hsa-miR-3678-3p hsa-let-7d hsa-miR-199a-3p hsa-miR-4305 hsa-miR-25 hsa-miR-3138 hsa-miR-519a hsa-miR-3921

		SwitchGear 3'UTR luciferase reporter plasmid: SCUBE3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCUBE3 (see all 4) OriGene shRNA RFP: SCUBE3 OriGene siRNA: SCUBE3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCUBE3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SCUBE3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: SCUBE3 (NM_152753)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SCUBE3
		Search LifeMap BioReagents cell lines for SCUBE3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCUBE3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	--

SCUBE3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SCUBE3:

Increased gamma-H2AX phosphory

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Scube3):

normal

SCUBE3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SCUBE3

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for SCUBE3 (Q8IX30^{1, 3} ENSP00000274938⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SCUBE1	Q8IWY4³, ENSP00000354080⁴	I2D: score=1 STRING: ENSP00000354080
MMP9	P14780¹, ENSP00000361405⁴	EBI-4479975,EBI-1382326 STRING: ENSP00000361405
MMP2	P08253¹, ENSP00000219070⁴	EBI-4479975,EBI-1033518 STRING: ENSP00000219070
TGFBR2	P37173¹, ENSP00000351905⁴	EBI-4479975,EBI-296151 STRING: ENSP00000351905

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0051260	protein homooligomerization	IDA	15234972
GO:0051291	protein heterooligomerization	IPI	15234972

SCUBE3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SCUBE3
Search CenterWatch for drugs/clinical trials and news about SCUBE3 / SCUB3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SCUBE3 gene:

NM_152753.2

Unigene Cluster for SCUBE3:

Signal peptide, CUB domain, EGF-like 3

Hs.12923 [show with all ESTs]

Unigene Representative Sequence: CR936873

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000274938 ENST00000394681(uc003okf.1 uc003okg.1 uc003okh.1)

miRNA Products:		OriGene 3'-UTR Clone: SCUBE3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCUBE3
		8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate SCUBE3 (see all 57):
		hsa-miR-3678-3p hsa-let-7d hsa-miR-199a-3p hsa-miR-4305 hsa-miR-25 hsa-miR-3138 hsa-miR-519a hsa-miR-3921

		SwitchGear 3'UTR luciferase reporter plasmid: SCUBE3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCUBE3 (see all 4) OriGene shRNA RFP: SCUBE3 OriGene siRNA: SCUBE3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCUBE3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCUBE3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCUBE3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SCUBE3 (NM_152753)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCUBE3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCUBE3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCUBE3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCUBE3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCUBE3

Additional cDNA sequence:

AF452494.1 AK092010.1 AK092062.1 AK123742.1 AK124068.1 AK291218.1 AY639608.1 BC052263.1

BX537875.1 CR936607.1 CR936873.1

6 DOTS entries:

DT.307834 DT.307289 DT.95257982 DT.121386754 DT.75160945 DT.99976547

24/119 AceView cDNA sequences (see all 119):

AI085957 AK092062 BU188419 AI215040 AI867286 BF477769 AW339282 CD638062

AI074335 NM_152753 AI793257 BF433903 N41988 AI631034 AK092010 AF452494

BE674338 AA971884 AX747339 CA449259 AA366405 AI377420 BE504338 BQ008457

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SCUBE3 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24a	·	24b	·
SP1:																																											-
SP2:															-																												-
SP3:																																													-		-		-

ExUns:	24c
SP1:
SP2:
SP3:

ECgene alternative splicing isoforms for SCUBE3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCUBE3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGAGGCTT

About this image

SCUBE3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SCUBE3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCUBE3

SOURCE GeneReport for Unigene cluster: Hs.12923

UniProtKB/Swiss-Prot: SCUB3_HUMAN, Q8IX30

Tissue specificity: Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells.

Tends to be up-regulated in lung cancer cells

SABiosciences Custom PCR Arrays for SCUBE3

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCUBE3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCUBE3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SCUBE3 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SCUBE3¹	signal peptide, CUB domain, EGF-like 3	79.18(n) 83.83(a)		419896 XM_418021.3 XP_418021.3
lizard (Anolis carolinensis)	Reptilia	SCUBE3⁶ --	--	81(a) 1(a)	1 ↔ 1 possible ortholog	4(120630667-120734978) AAWZ02039088(481-7051)
zebrafish (Danio rerio)	Actinopterygii	scube3¹	signal peptide, CUB domain, EGF-like 3	70.15(n) 71.6(a)		100000687 XM_001340802.4 XP_001340838.4
fruit fly (Drosophila melanogaster)	Insecta	dp⁶	dumpy		1 → many	2L(4477462-4595054)
worm (Caenorhabditis elegans)	Secernentea	mec-9⁶	MEChanosensory abnormality family member (mec-9)	9(a)	1 → many	V(9907608-9915063)

ENSEMBL Gene Tree for SCUBE3 (if available)
TreeFam Gene Tree for SCUBE3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SCUBE3 gene

FBN1² LTBP3² FBN3² FBLN5² FBN2² LTBP4² EFEMP1² EFEMP2²

SCUBE1² LTBP2² LTBP1² FBLN2² FBLN1² SCUBE2²

3 SIMAP similar genes for SCUBE3 using alignment to 1 protein entry: SCUB3_HUMAN:

DKFZp686D20108 SCUBE1 SCUBE2

SCUBE3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144779552^1,2		--	35180331(+)	`CAGCAC/TCATTG`	1	--	us2k¹		0	--	--	--	--
rs190214668^1,2		--	35180381(+)	`CCAATA/CTGGAA`	1	--	us2k¹		0	--	--	--	--
rs3800391^1,2	C,H,	--	35180781(-)	`CAAACC/GTGCAC`	1	--	us2k¹		6		EA NS	2036
rs75113235^1,2		--	35180894(+)	`TATGTG/TAGTCC`	1	--	us2k¹		1		NA	120
rs181245510^1,2		--	35180915(+)	`GGGTAA/GGGTGG`	1	--	us2k¹		0	--	--	--	--
rs9368854^1,2	C,F,H,	--	35181236(+)	`TCTCGG/TGTGGA`	1	--	us2k¹		15		NS EA WA NA	2336
rs73748070^1,2	C,	--	35181321(+)	`CTTTCC/GTAGGG`	1	--	us2k¹		2		WA	120
rs79881668^1,2	F,	--	35181331(+)	`GGAGCG/AAGGAC`	1	--	us2k¹		1		EA	120
rs9462062^1,2	C,	--	35181455(+)	`GACCAG/TGCCCG`	1	--	us2k¹		2		WA	120
rs77122605^1,2	F,	--	35181681(+)	`AGAAAG/AAGGAG`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for SCUBE3 (35182190 - 35220856 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SCUBE3
1 CNV: 3606

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCUBE3

DNA2.0 Custom Variant and Variant Library Synthesis for SCUBE3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SCUBE3 for disorders           About GeneDecksing

OMIM gene information: 614708    OMIM disorders: --

2 diseases for SCUBE3:    About MalaCards

paget's disease of bone lung cancer

Human Genome Epidemiology (HuGE) Navigator: SCUBE3 (1 document)

Export disorders for SCUBE3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SCUBE3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SCUBE3)

Utopia: connect your pdf to the dynamic
world of online information

SCUBE3 is an endogenous TGF-I^ receptor ligand and reg ulates the epithelial-mesenchymal transition in lung cancer. (PubMed id 21441952)^{1, 2} Wu Y.Y....Yang P.C. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones. (PubMed id 15234972)^{1, 2} Wu B.-T....Yang R.-B. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. (PubMed id 12270931)^{1, 3} Yang R.-B.... Topper J.N. (2002)
The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)¹ Zhao J....Grant S.F. (2010)
Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)¹ Gudbjartsson D.F....Stefansson K. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 222663	HGNC: 13655	AceView: SCUBE3	Ensembl:ENSG00000146197	euGenes: HUgn222663
ECgene: SCUBE3	H-InvDB: SCUBE3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SCUBE3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SCUBE3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SCUBE3 gene:
Search GeneIP for patents involving SCUBE3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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signal peptide, CUB domain, EGF-like 3

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SCUBE3 Gene

signal peptide, CUB domain, EGF-like 3

Aliasesfor SCUBE3 gene

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Protein Domains /Familiesfor SCUBE3 gene

Functionfor SCUBE3 gene

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Expression
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Disorders / Diseases
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Intellectual Property
for SCUBE3 gene

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