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SCUBE3 Gene

protein-coding   GIFtS: 51
GCID: GC06P035182

Signal Peptide, CUB Domain, EGF-Like 3

(Previous name: CUB domain and EGF-like repeat containing 3)
(Previous symbol: CEGF3)
  Search for SCUBE3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Peptide, CUB Domain, EGF-Like 31 2
CEGF31 2 3
CUB Domain And EGF-Like Repeat Containing 31 2
CUB And EGF Containing Protein 32
Signal Peptide, CUB And EGF-Like Domain Containing Protein 32
Signal Peptide, CUB And EGF-Like Domain-Containing Protein 32

External Ids:    HGNC: 136551   Entrez Gene: 2226632   Ensembl: ENSG000001461977   OMIM: 6147085   UniProtKB: Q8IX303   

Export aliases for SCUBE3 gene to outside databases

Previous GC identifers: GC06P035231 GC06P035290 GC06P034902


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SCUBE3 Gene:
SCUBE3 (signal peptide, CUB domain, EGF-like 3) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is LTBP3.

UniProtKB/Swiss-Prot: SCUB3_HUMAN, Q8IX30
Function: Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous
autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate
epithelial-mesenchymal transition and cancer progression




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCUBE3 gene promoter:
         oct-B2   HOXA3   FOXF2   Olf-1   E47   FOXL1   POU2F2C   SRY   FOXO4   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCUBE3 promoter sequence
   Search Chromatin IP Primers for SCUBE3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCUBE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.3

SCUBE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCUBE3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P035182:  view genomic region     (about GC identifiers)

Start:
35,182,190 bp from pter      End:
35,220,856 bp from pter
Size:
38,667 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SCUB3_HUMAN, Q8IX30 (See protein sequence)
Recommended Name: Signal peptide, CUB and EGF-like domain-containing protein 3 precursor  
Size: 993 amino acids; 109282 Da
Subunit: Forms homooligomers and heterooligomers with SCUBE1. Interacts with TGFBR2 through the CUB domain; this
interaction does not affect TGFB1-binding to TGFBR2
Sequence caution: Sequence=BAC03798.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5A3 Q5CZB3 Q86UZ9 Q8NAU9
Alternative splicing: 2 isoforms:  Q8IX30-1   Q8IX30-2   

Explore the universe of human proteins at neXtProt for SCUBE3: NX_Q8IX30

Explore proteomics data for SCUBE3 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Proteolytic cleavage produces a CUB-containing C-terminal fragment that retains the ability to bind to TGFBR2.
    This reaction is catalyzed in vitro by MMP2 and, to a lesser extent, by MMP91
  • Glycosylation2 at Asn417, Asn464, Asn685, Asn756, Asn785

  • See SCUBE3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689966.2  
    ENSEMBL proteins: 
     ENSP00000274938   ENSP00000378174  

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    Cloud-Clone Corp. Proteins for SCUBE3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR000742 EG-like_dom
     IPR026823 cEGF
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR024731 EGF_dom_MSP1-like

    Graphical View of Domain Structure for InterPro Entry Q8IX30

    ProtoNet protein and cluster: Q8IX30

    3 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000859 CUB domain
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: SCUB3_HUMAN, Q8IX30
    Similarity: Contains 1 CUB domain
    Similarity: Contains 9 EGF-like domains


    Find genes that share domains with SCUBE3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCUB3_HUMAN, Q8IX30
    Function: Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous
    autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate
    epithelial-mesenchymal transition and cancer progression

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI15234972
         
    Find genes that share ontologies with SCUBE3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SCUBE3:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Scube3):
     normal 

    Find genes that share phenotypes with SCUBE3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Scube3tm1(KOMP)Vlcg for SCUBE3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCUBE3
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    Selected qRT-PCR Assays for microRNAs that regulate SCUBE3 (see all 57):
    hsa-miR-3678-3p hsa-let-7d hsa-miR-199a-3p hsa-miR-4305 hsa-miR-25 hsa-miR-3138 hsa-miR-519a hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidSCUBE3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCUB3_HUMAN, Q8IX30: Secreted. Cell surface
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0009986cell surface IDA15234972

    Find genes that share ontologies with SCUBE3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCUBE3
    Interactions:

        Search GeneGlobe Interaction Network for SCUBE3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SCUBE3 (Q8IX301, 3 ENSP000002749384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCUBE1Q8IWY43, ENSP000003540804I2D: score=1 STRING: ENSP00000354080
    MMP9P147801, ENSP000003614054EBI-4479975,EBI-1382326 STRING: ENSP00000361405
    MMP2P082531, ENSP000002190704EBI-4479975,EBI-1033518 STRING: ENSP00000219070
    TGFBR2P371731, ENSP000003519054EBI-4479975,EBI-296151 STRING: ENSP00000351905
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051260protein homooligomerization IDA15234972
    GO:0051291protein heterooligomerization IPI15234972

    Find genes that share ontologies with SCUBE3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCUBE3 (SCUB3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCUBE3 gene: 
    NM_152753.2  

    Unigene Cluster for SCUBE3:

    Signal peptide, CUB domain, EGF-like 3
    Hs.12923  [show with all ESTs]
    Unigene Representative Sequence: CR936873
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274938 ENST00000394681(uc003okf.1 uc003okg.1 uc003okh.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SCUBE3 (see all 57):
    hsa-miR-3678-3p hsa-let-7d hsa-miR-199a-3p hsa-miR-4305 hsa-miR-25 hsa-miR-3138 hsa-miR-519a hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidSCUBE3 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SCUBE3
      QuantiFast Probe-based Assays in human, mouse, rat SCUBE3

    Additional mRNA sequence: 

    AF452494.1 AK092010.1 AK092062.1 AK123742.1 AK124068.1 AK291218.1 AY639608.1 BC052263.1 
    BX537875.1 CR936607.1 CR936873.1 

    6 DOTS entries:

    DT.307834  DT.307289  DT.95257982  DT.121386754  DT.75160945  DT.99976547 

    Selected AceView cDNA sequences (see all 119):

    AA366405 BE218890 BQ771858 AX747309 AA934916 BE674338 AK092010 AW339282 
    BF477769 AX747339 BE504338 NM_152753 AI074335 AI292215 BU171604 AK092062 
    AV650845 AY639608 AI377420 AW205430 AI867286 BC052263 BQ008457 AV704511 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SCUBE3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ·
    SP1:                                                                                                                                -                           
    SP2:                                            -                                                                                   -                           
    SP3:                                                                                                                                      -     -     -         

    ExUns: 24c
    SP1:      
    SP2:      
    SP3:      


    ECgene alternative splicing isoforms for SCUBE3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCUBE3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGAGGCTT
    SCUBE3 Expression
    About this image


    SCUBE3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Maxillary Process
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Umbilical cord blood-derived mesenchymal stem cells
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    SCUBE3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCUBE3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12923

    UniProtKB/Swiss-Prot: SCUB3_HUMAN, Q8IX30
    Tissue specificity: Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial
    cells. Tends to be up-regulated in lung cancer cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCUBE3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SCUBE3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scube31 , 5 signal peptide, CUB domain, EGF-like 31, 5 90.16(n)1
    95.87(a)1
      17 (14.63 cM)5
    2689351  NM_001004366.11  NP_001004366.11 
     281423165 
    chicken
    (Gallus gallus)
    Aves SCUBE31 signal peptide, CUB domain, EGF-like 3 79.18(n)
    83.83(a)
      419896  XM_004935034.1  XP_004935091.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCUBE36
    signal peptide, CUB domain, EGF-like 3
    82(a)
    1 ↔ 1
    4(120628086-120779710)
    zebrafish
    (Danio rerio)
    Actinopterygii scube31 signal peptide, CUB domain, EGF-like 3 70.91(n)
    72.25(a)
      100000687  NM_001260501.1  NP_001247430.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG323736
    --
    22(a)
    1 → many
    3L(7643648-7752223)


    ENSEMBL Gene Tree for SCUBE3 (if available)
    TreeFam Gene Tree for SCUBE3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCUBE3 gene
    LTBP32  HMCN12  FBLN52  MEGF62  EFEMP12  LTBP42  SCUBE12  EFEMP22  
    LTBP22  HMCN22  LTBP12  FBLN22  FBLN12  SCUBE22  
    3 SIMAP similar genes for SCUBE3 using alignment to 1 protein entry:     SCUB3_HUMAN:
    DKFZp686D20108    SCUBE1    SCUBE2

    Find genes that share paralogs with SCUBE3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCUBE3 (see all 797)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs606579451,2
    C--34939721(+) TTTTC-/TTTT  
            
    TAACT
    1 -- ut310--------
    rs1447795521,2
    C--35180331(+) CAGCAC/TCATTG 1 -- us2k10--------
    rs1902146681,2
    --35180381(+) CCAATA/CTGGAA 1 -- us2k10--------
    rs38003911,2
    C,H--35180781(-) CAAACC/GTGCAC 1 -- us2k16Minor allele frequency- G:0.02EA NS 2036
    rs751132351,2
    C,F--35180894(+) TATGTG/TAGTCC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1812455101,2
    C--35180915(+) GGGTAA/GGGTGG 1 -- us2k10--------
    rs93688541,2
    C,F,H--35181236(+) TCTCGG/TGTGGA 1 -- us2k115Minor allele frequency- T:0.11NS EA WA NA 2336
    rs737480701,2
    C,F--35181321(+) CTTTCC/GTAGGG 1 -- us2k12Minor allele frequency- G:0.05WA 120
    rs798816681,2
    F--35181331(+) GGAGCG/AAGGAC 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs94620621,2
    C,F--35181455(+) GACCAG/TGCCCG 1 -- us2k12Minor allele frequency- T:0.18WA 120

    HapMap Linkage Disequilibrium report for SCUBE3 (35182190 - 35220856 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SCUBE3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1939e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCUBE3
    DNA2.0 Custom Variant and Variant Library Synthesis for SCUBE3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614708    OMIM disorders: --


    Find genes that share disorders with SCUBE3           About GenesLikeMe

    Genetic Association Database (GAD): SCUBE3
    Human Genome Epidemiology (HuGE) Navigator: SCUBE3 (1 document)

    Export disorders for SCUBE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCUBE3 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with SCUBE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SCUBE3 is an endogenous TGF-beta receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer. (PubMed id 21441952)1, 2 Wu Y.Y.... Yang P.C. (Oncogene 2011)
    2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    3. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones. (PubMed id 15234972)1, 2 Wu B.-T....Yang R.-B. (J. Biol. Chem. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. (PubMed id 12270931)1, 3 Yang R.-B.... Topper J.N. (J. Biol. Chem. 2002)
    9. SCUBE3 regulation of early lung cancer angiogenesis and metastatic progression. (PubMed id 23420440)1 Chou C.H....Chang C. (amp 2013)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 222663 HGNC: 13655 AceView: SCUBE3 Ensembl:ENSG00000146197 euGenes: HUgn222663
    ECgene: SCUBE3 H-InvDB: SCUBE3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SCUBE3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCUBE3 gene:
    Search GeneIP for patents involving SCUBE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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