Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SCUBE2 Gene

protein-coding   GIFtS: 50
GCID: GC11M009041

Signal Peptide, CUB Domain, EGF-Like 2

  Search for SCUBE2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Signal Peptide, CUB Domain, EGF-Like 21 2
CEGP12 3
CEGB12
CEGF12
Signal Peptide, CUB And EGF-Like Domain-Containing Protein 22
Protein CEGP13

External Ids:    HGNC: 304251   Entrez Gene: 577582   Ensembl: ENSG000001753567   OMIM: 6117475   UniProtKB: Q9NQ363   

Export aliases for SCUBE2 gene to outside databases

Previous GC identifers: GC11M009733 GC11M009081 GC11M009006 GC11M008999 GC11M008711


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SCUBE2 Gene:
SCUBE2 (signal peptide, CUB domain, EGF-like 2) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is LTBP3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCUBE2 gene promoter:
         RP58   HEN1   POU2F1   POU2F1b   FOXJ2 (long isoform)   FOXO4   POU2F1a   POU2F1c   FOXJ2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCUBE2 promoter sequence
   Search Chromatin IP Primers for SCUBE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCUBE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.3

SCUBE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCUBE2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M009041:  view genomic region     (about GC identifiers)

Start:
9,041,047 bp from pter      End:
9,159,661 bp from pter
Size:
118,615 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SCUB2_HUMAN, Q9NQ36 (See protein sequence)
Recommended Name: Signal peptide, CUB and EGF-like domain-containing protein 2 precursor  
Size: 999 amino acids; 109966 Da
Subunit: Forms homooligomers and heterooligomers with SCUBE1 and SCUBE3 (By similarity)
Secondary accessions: Q2NKQ8 Q6ZWI1
Alternative splicing: 3 isoforms:  Q9NQ36-1   Q9NQ36-2   Q9NQ36-3   

Explore the universe of human proteins at neXtProt for SCUBE2: NX_Q9NQ36

Explore proteomics data for SCUBE2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn659

  • See SCUBE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001164161.1  NP_066025.2  

    ENSEMBL proteins: 
     ENSP00000310658   ENSP00000415187   ENSP00000429969   ENSP00000435902   ENSP00000432828  
     ENSP00000435415   ENSP00000434000   ENSP00000390481  

    SCUBE2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SCUBE2
    GenScript Custom Purified and Recombinant Proteins Services for SCUBE2
    Novus Biologicals SCUBE2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCUBE2

     
    Search eBioscience for Proteins for SCUBE2 

    SCUBE2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SCUBE2
    OriGene Custom Antibody Services for SCUBE2
    Novus Biologicals SCUBE2 Antibodies
    Abcam antibodies for SCUBE2
    Cloud-Clone Corp. Antibodies for SCUBE2
    ThermoFisher Antibodies for SCUBE2
    LSBio Antibodies in human, mouse, rat for SCUBE2

    SCUBE2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SCUBE2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCUBE2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SCUBE2
    Cloud-Clone Corp. CLIAs for SCUBE2
    Search eBioscience for ELISAs for SCUBE2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 9):
     IPR000742 EG-like_dom
     IPR026823 cEGF
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR000859 CUB_dom

    Graphical View of Domain Structure for InterPro Entry Q9NQ36

    ProtoNet protein and cluster: Q9NQ36

    2 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: SCUB2_HUMAN, Q9NQ36
    Similarity: Contains 1 CUB domain
    Similarity: Contains 9 EGF-like domains


    Find genes that share domains with SCUBE2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SCUBE2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCUBE2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SCUBE2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCUBE2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCUBE2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SCUBE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCUBE2 (see all 17):
    hsa-miR-3194-5p hsa-miR-1278 hsa-miR-765 hsa-miR-4267 hsa-miR-9 hsa-miR-298 hsa-miR-924 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidSCUBE2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SCUBE2
    Predesigned siRNA for gene silencing in human, mouse, rat SCUBE2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SCUBE2

    Clone
    Products:
         
    OriGene clones in human, mouse for SCUBE2 (see all 11)
    OriGene ORF clones in mouse, rat for SCUBE2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SCUBE2 (NM_020974)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCUBE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCUBE2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SCUBE2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SCUBE2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCUBE2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SCUB2_HUMAN, Q9NQ36: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with SCUBE2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCUBE2
    Interactions:

        Search GeneGlobe Interaction Network for SCUBE2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SCUBE2 (ENSP000003106584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCUBE1ENSP000003540804STRING: ENSP00000354080
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCUBE2 (SCUB2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SCUBE2 gene (2 alternative transcripts): 
    NM_001170690.1  NM_020974.2  

    Unigene Cluster for SCUBE2:

    Signal peptide, CUB domain, EGF-like 2
    Hs.523468  [show with all ESTs]
    Unigene Representative Sequence: NM_020974
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309263 ENST00000524317 ENST00000450649 ENST00000520467 ENST00000518447
    ENST00000532532 ENST00000528651 ENST00000519202 ENST00000519535 ENST00000530265
    ENST00000519788 ENST00000531429 ENST00000534295 ENST00000457346(uc021qdk.1 uc001mhi.2 uc001mhj.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SCUBE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCUBE2 (see all 17):
    hsa-miR-3194-5p hsa-miR-1278 hsa-miR-765 hsa-miR-4267 hsa-miR-9 hsa-miR-298 hsa-miR-924 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidSCUBE2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SCUBE2
    Predesigned siRNA for gene silencing in human, mouse, rat SCUBE2
    Clone
    Products:
         
    OriGene clones in human, mouse for SCUBE2 (see all 11)
    OriGene ORF clones in mouse, rat for SCUBE2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SCUBE2 (NM_020974)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCUBE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCUBE2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SCUBE2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SCUBE2
      QuantiTect SYBR Green Assays in human, mouse, rat SCUBE2
      QuantiFast Probe-based Assays in human, mouse, rat SCUBE2

    Additional mRNA sequence: 

    AF086390.1 AK092153.1 AK123039.1 AK126806.1 BC111690.1 

    11 DOTS entries:

    DT.444966  DT.97821123  DT.95200839  DT.40273612  DT.101969065  DT.102824644  DT.92451890  DT.100780237 
    DT.120693545  DT.95268249  DT.97855362 

    Selected AceView cDNA sequences (see all 90):

    AK123039 BM142057 AI000160 AI247191 CK819866 AW613178 AA256485 AI276664 
    AA639700 W74079 BE677567 AF086390 AI380982 AI342436 NM_020974 BX090430 
    AK131552 AI298488 AI420272 BE855854 BF437295 AA256985 CB050246 BE542706 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SCUBE2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a ·
    SP1:                                                                                                        -     -                                             
    SP2:                                                                    -     -     -     -     -                 -                 -     -                     
    SP3:                                                                                                              -                                             
    SP4:                                                                                                                                                            

    ExUns: 23b · 23c
    SP1:            
    SP2:            
    SP3:            
    SP4:            


    ECgene alternative splicing isoforms for SCUBE2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SCUBE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGCACAGT
    SCUBE2 Expression
    About this image


    SCUBE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Heart (Cardiovascular System)
             Cardiac Crescent Cells Cardiac Crescent
    SCUBE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCUBE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523468

    UniProtKB/Swiss-Prot: SCUB2_HUMAN, Q9NQ36
    Tissue specificity: Expressed in a broad spectrum of adult tissues

        Custom PCR Arrays for SCUBE2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SCUBE2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SCUBE2
    QuantiTect SYBR Green Assays in human, mouse, rat SCUBE2
    QuantiFast Probe-based Assays in human, mouse, rat SCUBE2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCUBE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SCUBE2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scube21 , 5 signal peptide, CUB domain, EGF-like 21, 5 88.29(n)1
    89.88(a)1
      7 (57.53 cM)5
    567881  NM_020052.21  NP_064436.21 
     1097986765 
    chicken
    (Gallus gallus)
    Aves SCUBE21 signal peptide, CUB domain, EGF-like 2 75.59(n)
    78.62(a)
      423049  XM_420982.4  XP_420982.3 
    lizard
    (Anolis carolinensis)
    Reptilia SCUBE26
    signal peptide, CUB domain, EGF-like 2
    73(a)
    1 ↔ 1
    1(64381896-64425345)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia scube21 signal peptide, CUB domain, EGF-like 2 68.58(n)
    69.6(a)
      779957  NM_001079034.1  NP_001072502.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.38482 Transcribed sequence with weak similarity to protein more 73.64(n)    57048102 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG323736
    --
    22(a)
    1 → many
    3L(7643648-7752223)


    ENSEMBL Gene Tree for SCUBE2 (if available)
    TreeFam Gene Tree for SCUBE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SCUBE2 gene
    LTBP32  HMCN12  SCUBE32  FBLN52  MEGF62  EFEMP12  LTBP42  SCUBE12  
    EFEMP22  LTBP22  LTBP12  HMCN22  FBLN22  FBLN12  
    Selected SIMAP similar genes for SCUBE2 using alignment to 6 protein entries:     SCUB2_HUMAN (see all proteins) (see all similar genes):
    DKFZp686B09105    SCUBE1    DKFZp686D20108    SCUBE3    F9    PROC
    CUBN    LDLR    CSMD1    LRP8    SEZ6    PROS1
    MATN2    NRP2    EFEMP1    FBLN2    LTBP1    DKFZp686L21135

    Find genes that share paralogs with SCUBE2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SCUBE2
    PGOHUM00000238260


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SCUBE2 (see all 1517)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387390381,2
    --9040586(+) CCAGGC/TAGAAG 2 -- int10--------
    rs1916809531,2
    --9040731(+) TTGTGC/TGTGTA 2 -- int10--------
    rs793668741,2
    F--9040797(+) TGACCG/AGGTTT 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1141932371,2
    F--9040952(+) AGTGCG/AGTCAC 2 -- int11Minor allele frequency- A:0.03WA 118
    rs728560201,2
    C--9040980(+) ACATTC/TGAATT 2 -- int14Minor allele frequency- T:0.10CSA WA NA EA 360
    rs728560211,2
    C--9041011(+) AGAAAT/CATAGG 2 -- int14Minor allele frequency- C:0.10CSA WA NA EA 360
    rs1401523621,2
    --9041052(+) TTGTTC/TTAATG 2 -- ut310--------
    rs352162761,2
    C--9041071(+) TTTTAT/-ATGAT 2 -- ut311Minor allele frequency- -:0.50NA 2
    rs1841910201,2
    --9041398(+) CTGTAA/GTGAGA 2 -- ut310--------
    rs1502978861,2
    C--9041409(+) TTTTTC/GCTTGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SCUBE2 (9041047 - 9159661 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SCUBE2 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744091CNV Deletion23290073
    esv2744090CNV Deletion23290073
    esv1003548CNV Insertion20482838
    esv1135936CNV Insertion17803354
    esv267588CNV Insertion20981092
    nsv7667CNV Insertion18451855
    nsv467706CNV Loss19166990
    esv33264CNV Loss17666407
    nsv896984CNV Gain21882294
    nsv896985CNV Gain21882294

    Human Gene Mutation Database (HGMD): SCUBE2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCUBE2
    DNA2.0 Custom Variant and Variant Library Synthesis for SCUBE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611747    OMIM disorders: --


    Find genes that share disorders with SCUBE2           About GenesLikeMe

    Genetic Association Database (GAD): SCUBE2
    Human Genome Epidemiology (HuGE) Navigator: SCUBE2 (5 documents)

    Export disorders for SCUBE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SCUBE2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SCUBE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. (PubMed id 12270931)1, 2, 3 Yang R.-B.... Topper J.N. (J. Biol. Chem. 2002)
    2. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PubMed id 11528127)1, 2, 3 Amid C.... Schmidt E.R. (Cytogenet. Cell Genet. 2001)
    3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    6. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    7. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Genetic determinants of plasma I^a88-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. (PubMed id 23279374)1 Athanasiadis G....Soria J.M. (J. Thromb. Haemost. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57758 HGNC: 30425 AceView: SCUBE2 Ensembl:ENSG00000175356 euGenes: HUgn57758
    ECgene: SCUBE2 H-InvDB: SCUBE2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SCUBE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SCUBE2 gene:
    Search GeneIP for patents involving SCUBE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SCUBE2   OriGene RNAi products in human, mouse, rat for SCUBE2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SCUBE2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SCUBE2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SCUBE2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SCUBE2   OriGene Custom Protein Services for SCUBE2  

     
     
     Block miRNA regulation of human, mouse, rat SCUBE2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SCUBE2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCUBE2 Predesigned siRNA for gene silencing in human, mouse, rat SCUBE2
     QuantiFast Probe-based Assays in human, mouse, rat SCUBE2 QuantiTect SYBR Green Assays in human, mouse, rat SCUBE2
     Custom PCR Arrays for SCUBE2 Search Chromatin IP Primers for SCUBE2
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SCUBE2  Search GeneGlobe Interaction Network for SCUBE2
     Regulatory tfbs in SCUBE2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SCUBE2 GenScript cDNA clones with any tag delivered in your preferred vector for SCUBE2
     GenScript Custom Assay Services for SCUBE2 GenScript Custom overexpressing Cell Line Services for SCUBE2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SCUBE2 (SCUB2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SCUBE2 antibodies
     SCUBE2 proteins
     Antibodies for SCUBE2
     See all of Abcam's Antibodies, Kits and Proteins for SCUBE2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SCUBE2
     Antibodies for SCUBE2
     ELISAs for SCUBE2
     CLIAs for SCUBE2



     Browse ESI BIO Cell Lines and PureStem Progenitors for SCUBE2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCUBE2
     SwitchGear 3'UTR luciferase reporter plasmids for SCUBE2
     SwitchGear Promoter luciferase reporter plasmids for SCUBE2
     ThermoFisher Antibodies for SCUBE2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCUBE2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCUBE2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SCUBE2
     LSBio Antibodies in human, mouse, rat for SCUBE2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SCUBE2
      Search eBioscience for proteins for SCUBE2
      Search eBioscience for elisas for SCUBE2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SCUBE2 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4