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Aliases for SCUBE2 Gene

Aliases for SCUBE2 Gene

  • Signal Peptide, CUB Domain And EGF Like Domain Containing 2 2 3 5
  • Signal Peptide, CUB Domain, EGF-Like 2 2 3
  • CEGP1 3 4
  • Signal Peptide, CUB And EGF-Like Domain-Containing Protein 2 3
  • Protein CEGP1 4
  • CEGB1 3
  • CEGF1 3

External Ids for SCUBE2 Gene

Previous GeneCards Identifiers for SCUBE2 Gene

  • GC11M009733
  • GC11M009081
  • GC11M009006
  • GC11M008999
  • GC11M008711

Summaries for SCUBE2 Gene

GeneCards Summary for SCUBE2 Gene

SCUBE2 (Signal Peptide, CUB Domain And EGF Like Domain Containing 2) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Signaling by GPCR. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SCUBE1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCUBE2 Gene

Genomics for SCUBE2 Gene

Regulatory Elements for SCUBE2 Gene

Enhancers for SCUBE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F009057 0.6 ENCODE 26.6 +80.9 80896 0.2 OSR2 CTCF ZNF366 FEZF1 ZNF24 ZEB2 ZNF843 SP7 SCUBE2 MIR5691 LOC105376541
GH11F009103 0.2 ENCODE 26.5 +34.3 34338 1.3 SCUBE2 TMEM41B KRT8P41 LOC105376542
GH11F009053 0.8 Ensembl ENCODE 22.9 +84.3 84317 1.2 MNT ZNF644 SCUBE2 MIR5691 LOC105376541
GH11F009161 0.2 Ensembl 22 -23.9 -23887 0.4 SCUBE2 DENND5A GC11M009222
GH11F009016 1.2 Ensembl ENCODE 21.7 +120.7 120713 1.6 FOSL1 FOS NFE2 ZIC2 SPI1 GABPA SCUBE2 ASCL3 ENSG00000223080 AKIP1 LOC105376541 MIR5691
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SCUBE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCUBE2 Gene

9,019,500 bp from pter
9,138,114 bp from pter
118,615 bases
Minus strand

Genomic View for SCUBE2 Gene

Genes around SCUBE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCUBE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCUBE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCUBE2 Gene

Proteins for SCUBE2 Gene

  • Protein details for SCUBE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal peptide, CUB and EGF-like domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q2NKQ8
    • Q6ZWI1

    Protein attributes for SCUBE2 Gene

    999 amino acids
    Molecular mass:
    109966 Da
    Quaternary structure:
    • Forms homooligomers and heterooligomers with SCUBE1 and SCUBE3.

    Alternative splice isoforms for SCUBE2 Gene


neXtProt entry for SCUBE2 Gene

Post-translational modifications for SCUBE2 Gene

  • Glycosylation at Asn 659
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SCUBE2 Gene

Domains & Families for SCUBE2 Gene

Suggested Antigen Peptide Sequences for SCUBE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUB domain.
  • Contains 1 CUB domain.
  • Contains 9 EGF-like domains.
genes like me logo Genes that share domains with SCUBE2: view

No data available for Gene Families for SCUBE2 Gene

Function for SCUBE2 Gene

Gene Ontology (GO) - Molecular Function for SCUBE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with SCUBE2: view
genes like me logo Genes that share phenotypes with SCUBE2: view

Animal Models for SCUBE2 Gene

MGI Knock Outs for SCUBE2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SCUBE2

miRNA for SCUBE2 Gene

miRTarBase miRNAs that target SCUBE2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCUBE2 Gene

Localization for SCUBE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCUBE2 Gene


Subcellular locations from

Jensen Localization Image for SCUBE2 Gene COMPARTMENTS Subcellular localization image for SCUBE2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SCUBE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with SCUBE2: view

Pathways & Interactions for SCUBE2 Gene

genes like me logo Genes that share pathways with SCUBE2: view

Pathways by source for SCUBE2 Gene

Gene Ontology (GO) - Biological Process for SCUBE2 Gene


No data available for SIGNOR curated interactions for SCUBE2 Gene

Transcripts for SCUBE2 Gene

Unigene Clusters for SCUBE2 Gene

Signal peptide, CUB domain, EGF-like 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCUBE2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a ·
SP1: - -
SP2: - - - - - - - -
SP3: -

ExUns: 23b · 23c

Relevant External Links for SCUBE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCUBE2 Gene

mRNA expression in normal human tissues for SCUBE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCUBE2 Gene

This gene is overexpressed in Bladder (x6.6) and Pancreas (x4.5).

Protein differential expression in normal tissues from HIPED for SCUBE2 Gene

This gene is overexpressed in Plasma (41.0), Urine (14.1), Breast (7.2), and Prostate (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCUBE2 Gene

Protein tissue co-expression partners for SCUBE2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCUBE2 Gene:


SOURCE GeneReport for Unigene cluster for SCUBE2 Gene:


mRNA Expression by UniProt/SwissProt for SCUBE2 Gene:

Tissue specificity: Expressed in a broad spectrum of adult tissues.
genes like me logo Genes that share expression patterns with SCUBE2: view

Primer Products

Orthologs for SCUBE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCUBE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCUBE2 34 35
  • 99.28 (n)
(Canis familiaris)
Mammalia SCUBE2 34 35
  • 91.13 (n)
(Bos Taurus)
Mammalia SCUBE2 34 35
  • 89.21 (n)
(Rattus norvegicus)
Mammalia Scube2 34
  • 88.52 (n)
(Mus musculus)
Mammalia Scube2 34 16 35
  • 88.29 (n)
(Monodelphis domestica)
Mammalia SCUBE2 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SCUBE2 35
  • 75 (a)
(Gallus gallus)
Aves SCUBE2 34 35
  • 75.59 (n)
(Anolis carolinensis)
Reptilia SCUBE2 35
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scube2 34
  • 68.58 (n)
(Danio rerio)
Actinopterygii scube2 34 35
  • 65.01 (n)
Dr.3848 34
fruit fly
(Drosophila melanogaster)
Insecta CG32373 35
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
Species where no ortholog for SCUBE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCUBE2 Gene

Gene Tree for SCUBE2 (if available)
Gene Tree for SCUBE2 (if available)

Paralogs for SCUBE2 Gene

Paralogs for SCUBE2 Gene Pseudogenes for SCUBE2 Gene

genes like me logo Genes that share paralogs with SCUBE2: view

Variants for SCUBE2 Gene

Sequence variations from dbSNP and Humsavar for SCUBE2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10572251 -- 9,045,606(+) AGACA(C/G)ACAGA intron-variant, downstream-variant-500B
rs10668342 -- 9,038,122(+) AGAGA(-/AG)AGAGA intron-variant
rs10732200 -- 9,079,771(+) TATTT(A/T)AAAAA intron-variant
rs10734641 -- 9,036,110(+) GTCTC(A/G)AACTC intron-variant
rs10743097 -- 9,030,504(+) ACCTG(C/T)GTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCUBE2 Gene

Variant ID Type Subtype PubMed ID
esv1003548 CNV insertion 20482838
esv1135936 CNV insertion 17803354
esv2744090 CNV deletion 23290073
esv2744091 CNV deletion 23290073
esv3303308 CNV mobile element insertion 20981092
esv33264 CNV loss 17666407
esv3436162 CNV insertion 20981092
esv3547294 CNV deletion 23714750
esv3891928 CNV gain 25118596
nsv467706 CNV loss 19166990
nsv499766 OTHER inversion 21111241
nsv553454 CNV loss 21841781
nsv553455 CNV loss 21841781
nsv7215 OTHER inversion 18451855
nsv7667 CNV insertion 18451855
nsv951307 CNV deletion 24416366

Variation tolerance for SCUBE2 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.21; 92.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCUBE2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCUBE2 Gene

Disorders for SCUBE2 Gene

Relevant External Links for SCUBE2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCUBE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCUBE2 Gene

Publications for SCUBE2 Gene

  1. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. (PMID: 12270931) Yang R.-B. … Topper J.N. (J. Biol. Chem. 2002) 2 3 4 64
  2. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PMID: 11528127) Amid C. … Schmidt E.R. (Cytogenet. Cell Genet. 2001) 2 3 4 64
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 46 64

Products for SCUBE2 Gene

Sources for SCUBE2 Gene

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