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Aliases for SCUBE2 Gene

Aliases for SCUBE2 Gene

  • Signal Peptide, CUB Domain And EGF Like Domain Containing 2 2 3 5
  • Signal Peptide, CUB Domain, EGF-Like 2 2 3
  • CEGP1 3 4
  • Signal Peptide, CUB And EGF-Like Domain-Containing Protein 2 3
  • Protein CEGP1 4
  • CEGB1 3
  • CEGF1 3

External Ids for SCUBE2 Gene

Previous GeneCards Identifiers for SCUBE2 Gene

  • GC11M009733
  • GC11M009081
  • GC11M009006
  • GC11M008999
  • GC11M008711

Summaries for SCUBE2 Gene

GeneCards Summary for SCUBE2 Gene

SCUBE2 (Signal Peptide, CUB Domain And EGF Like Domain Containing 2) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Signaling by Hedgehog. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SCUBE1.

Additional gene information for SCUBE2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCUBE2 Gene

Genomics for SCUBE2 Gene

Regulatory Elements for SCUBE2 Gene

Enhancers for SCUBE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H009208 1.3 Ensembl ENCODE dbSUPER 17 -72.1 -72137 4.2 HDGF PKNOX1 TBL1XR1 BMI1 BATF GTF3C2 ZNF121 ATF7 ETV6 RUNX3 DENND5A SCUBE2 SNORA3B IPO7 TMEM41B RPL27A TRIM66 GC11M009222
GH11H009158 1.2 FANTOM5 Ensembl ENCODE 16.7 -21.9 -21920 2.2 FOSL1 JUND JUN CEBPB CEBPG DENND5A NRIP3 SCUBE2 TMEM41B ZNF143 IPO7 TMEM9B RPL27A GC11M009222
GH11H009218 1.2 Ensembl ENCODE dbSUPER 15 -81.3 -81334 1.8 JUN MAX CEBPB ZNF266 EP300 RFX5 PRDM6 JUND ZNF624 STAT3 SNORA3B DENND5A SCUBE2 RPL27A ZNF143 RPL21P97 TMEM41B GC11M009222
GH11H009057 0.6 ENCODE 26.6 +80.9 80896 0.2 FEZF1 ZEB2 ZNF843 OSR2 ZSCAN21 PRDM6 ZNF366 GLI2 ZNF24 SP7 SCUBE2 MIR5691 LOC105376541
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCUBE2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SCUBE2 Gene

Genomic Locations for SCUBE2 Gene
118,615 bases
Minus strand

Genomic View for SCUBE2 Gene

Genes around SCUBE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCUBE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCUBE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCUBE2 Gene

Proteins for SCUBE2 Gene

  • Protein details for SCUBE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal peptide, CUB and EGF-like domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q2NKQ8
    • Q6ZWI1

    Protein attributes for SCUBE2 Gene

    999 amino acids
    Molecular mass:
    109966 Da
    Quaternary structure:
    • Forms homooligomers and heterooligomers with SCUBE1 and SCUBE3.

    Alternative splice isoforms for SCUBE2 Gene


neXtProt entry for SCUBE2 Gene

Post-translational modifications for SCUBE2 Gene

  • Glycosylation at isoforms=3659
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for SCUBE2
  • Santa Cruz Biotechnology (SCBT) Antibodies for SCUBE2

No data available for DME Specific Peptides for SCUBE2 Gene

Domains & Families for SCUBE2 Gene

Gene Families for SCUBE2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for SCUBE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SCUBE2: view

No data available for UniProtKB/Swiss-Prot for SCUBE2 Gene

Function for SCUBE2 Gene

Phenotypes From GWAS Catalog for SCUBE2 Gene

Gene Ontology (GO) - Molecular Function for SCUBE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with SCUBE2: view
genes like me logo Genes that share phenotypes with SCUBE2: view

Animal Models for SCUBE2 Gene

MGI Knock Outs for SCUBE2:

Animal Model Products

CRISPR Products

miRNA for SCUBE2 Gene

miRTarBase miRNAs that target SCUBE2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCUBE2 Gene

Localization for SCUBE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCUBE2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCUBE2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SCUBE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0009986 cell surface IBA --
genes like me logo Genes that share ontologies with SCUBE2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCUBE2 Gene

Pathways & Interactions for SCUBE2 Gene

genes like me logo Genes that share pathways with SCUBE2: view

Pathways by source for SCUBE2 Gene

Interacting Proteins for SCUBE2 Gene

Gene Ontology (GO) - Biological Process for SCUBE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with SCUBE2: view

No data available for SIGNOR curated interactions for SCUBE2 Gene

Drugs & Compounds for SCUBE2 Gene

No Compound Related Data Available

Transcripts for SCUBE2 Gene

Unigene Clusters for SCUBE2 Gene

Signal peptide, CUB domain, EGF-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCUBE2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a ·
SP1: - -
SP2: - - - - - - - -
SP3: -

ExUns: 23b · 23c

Relevant External Links for SCUBE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCUBE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCUBE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCUBE2 Gene

This gene is overexpressed in Bladder (x6.6) and Pancreas (x4.5).

Protein differential expression in normal tissues from HIPED for SCUBE2 Gene

This gene is overexpressed in Plasma (41.0), Urine (14.1), Breast (7.2), and Prostate (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCUBE2 Gene

Protein tissue co-expression partners for SCUBE2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCUBE2 Gene:


SOURCE GeneReport for Unigene cluster for SCUBE2 Gene:


mRNA Expression by UniProt/SwissProt for SCUBE2 Gene:

Tissue specificity: Expressed in a broad spectrum of adult tissues.
genes like me logo Genes that share expression patterns with SCUBE2: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCUBE2 Gene

Orthologs for SCUBE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCUBE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCUBE2 33 34
  • 99.28 (n)
(Canis familiaris)
Mammalia SCUBE2 33 34
  • 91.13 (n)
(Bos Taurus)
Mammalia SCUBE2 33 34
  • 89.21 (n)
(Rattus norvegicus)
Mammalia Scube2 33
  • 88.52 (n)
(Mus musculus)
Mammalia Scube2 33 16 34
  • 88.29 (n)
(Monodelphis domestica)
Mammalia SCUBE2 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SCUBE2 34
  • 75 (a)
(Gallus gallus)
Aves SCUBE2 33 34
  • 75.59 (n)
(Anolis carolinensis)
Reptilia SCUBE2 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scube2 33
  • 68.58 (n)
(Danio rerio)
Actinopterygii scube2 33 34
  • 65.01 (n)
Dr.3848 33
fruit fly
(Drosophila melanogaster)
Insecta CG32373 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for SCUBE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCUBE2 Gene

Gene Tree for SCUBE2 (if available)
Gene Tree for SCUBE2 (if available)

Paralogs for SCUBE2 Gene

Paralogs for SCUBE2 Gene Pseudogenes for SCUBE2 Gene

genes like me logo Genes that share paralogs with SCUBE2: view

Variants for SCUBE2 Gene

Sequence variations from dbSNP and Humsavar for SCUBE2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000002302 -- 9,071,110(+) GAAAG(C/T)GTTGT intron-variant
rs1000005310 -- 9,059,210(+) AGAAG(C/G)CTGAT intron-variant
rs1000084338 -- 9,059,641(+) GAGAA(C/T)GCTGA intron-variant, nc-transcript-variant
rs1000142630 -- 9,019,795(+) GGTAG(G/T)CCATC intron-variant, utr-variant-3-prime
rs1000161568 -- 9,054,906(+) ATCTT(C/G)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCUBE2 Gene

Variant ID Type Subtype PubMed ID
nsv951307 CNV deletion 24416366
nsv7667 CNV insertion 18451855
nsv7215 OTHER inversion 18451855
nsv553455 CNV loss 21841781
nsv553454 CNV loss 21841781
nsv499766 OTHER inversion 21111241
nsv467706 CNV loss 19166990
esv3891928 CNV gain 25118596
esv3547294 CNV deletion 23714750
esv3436162 CNV insertion 20981092
esv33264 CNV loss 17666407
esv3303308 CNV mobile element insertion 20981092
esv2744091 CNV deletion 23290073
esv2744090 CNV deletion 23290073
esv1135936 CNV insertion 17803354
esv1003548 CNV insertion 20482838

Variation tolerance for SCUBE2 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.21; 92.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCUBE2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCUBE2 Gene

Disorders for SCUBE2 Gene

Relevant External Links for SCUBE2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCUBE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCUBE2 Gene

Publications for SCUBE2 Gene

  1. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. (PMID: 12270931) Yang RB … Topper JN (The Journal of biological chemistry 2002) 2 3 4 60
  2. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PMID: 11528127) Amid C … Schmidt ER (Cytogenetics and cell genetics 2001) 2 3 4 60
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 45 60

Products for SCUBE2 Gene

Sources for SCUBE2 Gene

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