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Aliases for SCUBE1 Gene

Aliases for SCUBE1 Gene

  • Signal Peptide, CUB Domain And EGF Like Domain Containing 1 2 3
  • Signal Peptide, CUB Domain, EGF-Like 1 2 5

External Ids for SCUBE1 Gene

Previous GeneCards Identifiers for SCUBE1 Gene

  • GC22U990211
  • GC22M040206
  • GC22M041830
  • GC22M041924
  • GC22M043599
  • GC22M026558

Summaries for SCUBE1 Gene

Entrez Gene Summary for SCUBE1 Gene

  • This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]

GeneCards Summary for SCUBE1 Gene

SCUBE1 (Signal Peptide, CUB Domain And EGF Like Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is CD93.

UniProtKB/Swiss-Prot for SCUBE1 Gene

  • Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCUBE1 Gene

Genomics for SCUBE1 Gene

Regulatory Elements for SCUBE1 Gene

Enhancers for SCUBE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCUBE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCUBE1 Gene

43,197,283 bp from pter
43,343,388 bp from pter
146,106 bases
Minus strand

Genomic View for SCUBE1 Gene

Genes around SCUBE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCUBE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCUBE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCUBE1 Gene

Proteins for SCUBE1 Gene

  • Protein details for SCUBE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal peptide, CUB and EGF-like domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5R336

    Protein attributes for SCUBE1 Gene

    988 amino acids
    Molecular mass:
    107910 Da
    Quaternary structure:
    • Forms homooligomers and heterooligomers with SCUBE2 and SCUBE3.

neXtProt entry for SCUBE1 Gene

Proteomics data for SCUBE1 Gene at MOPED

Post-translational modifications for SCUBE1 Gene

  • Could be proteolytically cleaved to release a smaller active fragment.
  • N-glycosylated.
  • Glycosylation at Asn 370, Asn 466, Asn 679, Asn 750, Asn 779, and Asn 789
  • Modification sites at PhosphoSitePlus

Other Protein References for SCUBE1 Gene

No data available for DME Specific Peptides for SCUBE1 Gene

Domains & Families for SCUBE1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUB domain.
  • Contains 1 CUB domain.
  • Contains 9 EGF-like domains.
genes like me logo Genes that share domains with SCUBE1: view

No data available for Gene Families for SCUBE1 Gene

Function for SCUBE1 Gene

Molecular function for SCUBE1 Gene

UniProtKB/Swiss-Prot Function:
Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
UniProtKB/Swiss-Prot Induction:
Down-regulated by inflammatory cytokines.
genes like me logo Genes that share phenotypes with SCUBE1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCUBE1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCUBE1 Gene

Localization for SCUBE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCUBE1 Gene

Secreted. Cell membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for SCUBE1 Gene COMPARTMENTS Subcellular localization image for SCUBE1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SCUBE1 Gene

Pathways & Interactions for SCUBE1 Gene

SuperPathways for SCUBE1 Gene

No Data Available

Interacting Proteins for SCUBE1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000354080 Q8IWY4-SCUB1_HUMAN for SCUBE1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SCUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007512 adult heart development NAS 12270931
GO:0045446 endothelial cell differentiation NAS 12270931
GO:0051260 protein homooligomerization IPI 12270931
genes like me logo Genes that share ontologies with SCUBE1: view

No data available for Pathways by source and SIGNOR curated interactions for SCUBE1 Gene

Drugs & Compounds for SCUBE1 Gene

No Compound Related Data Available

Transcripts for SCUBE1 Gene

Unigene Clusters for SCUBE1 Gene

Signal peptide, CUB domain, EGF-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCUBE1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: - - - - - - -

ExUns: 22 ^ 23a · 23b

Relevant External Links for SCUBE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCUBE1 Gene

mRNA expression in normal human tissues for SCUBE1 Gene

mRNA differential expression in normal tissues according to GTEx for SCUBE1 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x10.9), Esophagus - Muscularis (x9.0), Nerve - Tibial (x6.5), and Ovary (x5.5).

Protein differential expression in normal tissues from HIPED for SCUBE1 Gene

This gene is overexpressed in Fetal testis (28.8), Spinal cord (11.7), Ovary (10.9), and Testis (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCUBE1 Gene

SOURCE GeneReport for Unigene cluster for SCUBE1 Gene Hs.133995

mRNA Expression by UniProt/SwissProt for SCUBE1 Gene

Tissue specificity: Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques.
genes like me logo Genes that share expression patterns with SCUBE1: view

Protein tissue co-expression partners for SCUBE1 Gene

Primer Products

Orthologs for SCUBE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCUBE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCUBE1 35
  • 90.06 (n)
  • 92.49 (a)
  • 92 (a)
(Canis familiaris)
Mammalia SCUBE1 35
  • 89.54 (n)
  • 92.57 (a)
  • 90 (a)
(Mus musculus)
Mammalia Scube1 35
  • 88.02 (n)
  • 92 (a)
Scube1 16
Scube1 36
  • 92 (a)
(Pan troglodytes)
Mammalia SCUBE1 35
  • 94.87 (n)
  • 93.8 (a)
(Rattus norvegicus)
Mammalia Scube1 35
  • 88.33 (n)
  • 92.41 (a)
(Monodelphis domestica)
Mammalia SCUBE1 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia SCUBE1 36
  • 75 (a)
(Gallus gallus)
Aves SCUBE1 35
  • 74.86 (n)
  • 85.58 (a)
  • 85 (a)
(Anolis carolinensis)
Reptilia SCUBE1 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scube1 35
  • 75.91 (n)
  • 82.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15105 35
(Danio rerio)
Actinopterygii scube1 35
  • 71.41 (n)
  • 77.74 (a)
zgc:158328 36
  • 24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32373 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for SCUBE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCUBE1 Gene

Gene Tree for SCUBE1 (if available)
Gene Tree for SCUBE1 (if available)

Paralogs for SCUBE1 Gene

Paralogs for SCUBE1 Gene

(11) SIMAP similar genes for SCUBE1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SCUBE1: view

Variants for SCUBE1 Gene

Sequence variations from dbSNP and Humsavar for SCUBE1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs129415 - 43,227,389(+) CTTCC(A/C/G/T)GTTCC reference, missense
rs138993 - 43,214,201(+) ACATG(A/G)CACAC reference, missense
rs6482 -- 43,206,657(+) AGAAG(-/AA/AAG)GGGCC intron-variant
rs53724 -- 43,251,948(-) TTACC(C/T)CAGGC intron-variant
rs129414 -- 43,227,347(+) GGAGG(A/G)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCUBE1 Gene

Variant ID Type Subtype PubMed ID
nsv834214 CNV Gain 17160897
esv33816 CNV Gain 17666407
nsv915201 CNV Loss 21882294
dgv4988n71 CNV Loss 21882294
nsv520927 CNV Loss 19592680
dgv4990n71 CNV Loss 21882294
dgv4991n71 CNV Loss 21882294
nsv471201 CNV Loss 18288195
nsv834216 CNV Loss 17160897
nsv915226 CNV Loss 21882294
dgv4992n71 CNV Loss 21882294
nsv191393 CNV Insertion 16902084
esv2724301 CNV Deletion 23290073
esv2676917 CNV Deletion 23128226
esv2724302 CNV Deletion 23290073
esv5307 CNV Deletion 18987735
esv2724303 CNV Deletion 23290073
esv2660751 CNV Deletion 23128226
dgv4993n71 CNV Loss 21882294
esv269389 CNV Insertion 20981092
dgv4994n71 CNV Loss 21882294
esv268558 CNV Insertion 20981092
esv270288 CNV Insertion 20981092
nsv459891 CNV Gain 19166990
nsv471202 CNV Gain 18288195
esv2330845 CNV Deletion 18987734
esv2628998 CNV Deletion 19546169
esv2677156 CNV Deletion 23128226
esv29705 CNV Gain 19812545
nsv821331 CNV Deletion 20802225
esv2215307 CNV Deletion 18987734
esv3472 CNV Deletion 18987735
dgv782e201 CNV Deletion 23290073
esv2724305 CNV Deletion 23290073
esv1076173 CNV Deletion 17803354
esv1613247 CNV Deletion 17803354
esv1000890 CNV Deletion 20482838
dgv4995n71 CNV Loss 21882294
esv2665956 CNV Deletion 23128226

Variation tolerance for SCUBE1 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.85; 91.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SCUBE1 Gene

Disorders for SCUBE1 Gene

Relevant External Links for SCUBE1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCUBE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCUBE1 Gene

Publications for SCUBE1 Gene

  1. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1). (PMID: 11087664) Grimmond S. … Greenfield A. (Genomics 2000) 2 3 23 67
  2. Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH). (PMID: 23918034) KA1hnisch J. … . (Clin Oral Investig 2014) 3
  3. Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1. (PMID: 23136397) Orr B. … Thomson A.A. (Dis Model Mech 2013) 3
  4. Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. (PMID: 23149075) Aslibekyan S. … Arnett D.K. (Nutr Metab Cardiovasc Dis 2013) 3
  5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3

Products for SCUBE1 Gene

Sources for SCUBE1 Gene