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SCUBE1 Gene

protein-coding   GIFtS: 52
GCID: GC22M043599

Signal Peptide, CUB Domain, EGF-Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Peptide, CUB Domain, EGF-Like 11 2
Signal Peptide, CUB And EGF-Like Domain-Containing Protein 12
Signal Peptide-CUB Domain-EGF-Related 12

External Ids:    HGNC: 134411   Entrez Gene: 802742   Ensembl: ENSG000001593077   OMIM: 6117465   UniProtKB: Q8IWY43   

Export aliases for SCUBE1 gene to outside databases

Previous GC identifers: GC22U990211 GC22M040206 GC22M041830 GC22M041924 GC22M026558


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCUBE1 Gene:
This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF
(epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies
of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and
endothelial cells and may play an important role in vascular biology. (provided by RefSeq, Oct 2011)

GeneCards Summary for SCUBE1 Gene:
SCUBE1 (signal peptide, CUB domain, EGF-like 1) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and calcium ion binding. An important paralog of this gene is LTBP3.

UniProtKB/Swiss-Prot: SCUB1_HUMAN, Q8IWY4
Function: Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical
role in vascular biology




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCUBE1 gene promoter:
         AREB6   CBF-B   RREB-1   HOXA5   Lmo2   STAT3   MyoD   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SCUBE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCUBE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13

SCUBE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCUBE1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M043599:  view genomic region     (about GC identifiers)

Start:
43,593,289 bp from pter      End:
43,739,394 bp from pter
Size:
146,106 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SCUB1_HUMAN, Q8IWY4 (See protein sequence)
Recommended Name: Signal peptide, CUB and EGF-like domain-containing protein 1 precursor  
Size: 988 amino acids; 107910 Da
Subunit: Forms homooligomers and heterooligomers with SCUBE2 and SCUBE3 (By similarity)
Secondary accessions: Q5R336

Explore the universe of human proteins at neXtProt for SCUBE1: NX_Q8IWY4

Explore proteomics data for SCUBE1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Could be proteolytically cleaved to release a smaller active fragment1
  • Glycosylation2 at Asn370, Asn466, Asn679, Asn750, Asn779, Asn789
  • Modification sites at PhosphoSitePlus

  • See SCUBE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_766638.2  
    ENSEMBL proteins: 
     ENSP00000354080   ENSP00000395327   ENSP00000290460  

    SCUBE1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SCUBE1

     
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    antibodies-online peptides for SCUBE1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR000742 EG-like_dom
     IPR026823 cEGF
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR024731 EGF_dom_MSP1-like

    Graphical View of Domain Structure for InterPro Entry Q8IWY4

    ProtoNet protein and cluster: Q8IWY4

    3 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000859 CUB domain
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: SCUB1_HUMAN, Q8IWY4
    Similarity: Contains 1 CUB domain
    Similarity: Contains 9 EGF-like domains


    Find genes that share domains with SCUBE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCUB1_HUMAN, Q8IWY4
    Function: Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical
    role in vascular biology
    Induction: Down-regulated by inflammatory cytokines

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding TAS12270931
    GO:0005515protein binding ----
    GO:0042802identical protein binding IDA12270931
    GO:0046982protein heterodimerization activity IDA12270931
         
    Find genes that share ontologies with SCUBE1           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SCUBE1:
     Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella-containin 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Scube1):
     craniofacial  embryogenesis  mortality/aging  nervous system  skeleton 

    Find genes that share phenotypes with SCUBE1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SCUBE1

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SCUBE1:
    hsa-miR-582-5p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidSCUBE1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCUB1_HUMAN, Q8IWY4: Secreted. Cell membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA12270931
    GO:0009897external side of plasma membrane IDA12270931
    GO:0009986cell surface IDA12270931
    GO:0019897extrinsic component of plasma membrane IDA12270931

    Find genes that share ontologies with SCUBE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SCUBE1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SCUBE1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SCUBE1 (Q8IWY43 ENSP000003540804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCUBE3Q8IX303, ENSP000002749384I2D: score=1 STRING: ENSP00000274938
    SCUBE2ENSP000003106584STRING: ENSP00000310658
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response NAS12270931
    GO:0007512adult heart development NAS12270931
    GO:0007596blood coagulation NAS12270931
    GO:0009791post-embryonic development NAS12270931
    GO:0045446endothelial cell differentiation NAS12270931

    Find genes that share ontologies with SCUBE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCUBE1 (SCUB1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCUBE1 gene: 
    NM_173050.3  

    Unigene Cluster for SCUBE1:

    Signal peptide, CUB domain, EGF-like 1
    Hs.133995  [show with all ESTs]
    Unigene Representative Sequence: NM_173050
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360835(uc003bdt.2) ENST00000449304 ENST00000290460(uc003bdu.2)
    ENST00000477991 ENST00000470433 ENST00000461595 ENST00000480833
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SCUBE1:
    hsa-miR-582-5p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidSCUBE1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat SCUBE1

    Additional mRNA sequence: 

    AF525689.1 AK127719.1 BC047916.1 BC127263.1 

    4 DOTS entries:

    DT.40270980  DT.100686589  DT.120646291  DT.40271245 

    Selected AceView cDNA sequences (see all 41):

    BX280767 BG191628 H55062 BM704709 H55691 CB162773 BM714681 BG204935 
    AK127719 BU736772 BQ183912 BQ716946 BM694185 BF724346 H55345 BU101645 
    BU101912 BQ448160 NM_173050 AI610643 AF525689 BU101852 BF725002 BU101644 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SCUBE1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                                                  -           -                                                                                             
    SP2:                                                  -           -                 -     -     -     -     -                                                   
    SP3:                                                                                                                                                            

    ExUns: 22 ^ 23a · 23b
    SP1:                  
    SP2:                  
    SP3:                  


    ECgene alternative splicing isoforms for SCUBE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCUBE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCCAGTGA
    SCUBE1 Expression
    About this image


    SCUBE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Prosencephalon
             Floor plate-like cells
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Eye (Sensory Organs)
    SCUBE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCUBE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.133995

    UniProtKB/Swiss-Prot: SCUB1_HUMAN, Q8IWY4
    Tissue specificity: Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha
    granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced
    by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized
    with the subendothelial matrices in atherosclerotic plaques

        Pathway & Disease-focused RT2 Profiler PCR Array including SCUBE1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCUBE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SCUBE1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scube11 , 5 signal peptide, CUB domain, EGF-like 11, 5 88.02(n)1
    92(a)1
      15 (39.40 cM)5
    647061  NM_001271472.11  NP_001258401.11 
     836049995 
    chicken
    (Gallus gallus)
    Aves SCUBE11 signal peptide, CUB domain, EGF-like 1 74.86(n)
    85.58(a)
      418228  XM_004938024.1  XP_004938081.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCUBE16
    signal peptide, CUB domain, EGF-like 1
    83(a)
    1 ↔ 1
    5(86455812-86708147)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151052 Xenopus laevis transcribed sequence with moderate similarity more 77.07(n)    CF519900.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scube11 signal peptide, CUB domain, EGF-like 1 71.41(n)
    77.74(a)
      797832  NM_001260500.1  NP_001247429.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG323736
    --
    23(a)
    1 → many
    3L(7643648-7752223)


    ENSEMBL Gene Tree for SCUBE1 (if available)
    TreeFam Gene Tree for SCUBE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCUBE1 gene
    LTBP32  HMCN12  SCUBE32  FBLN52  MEGF62  EFEMP12  LTBP42  EFEMP22  
    LTBP22  HMCN22  LTBP12  FBLN22  FBLN12  SCUBE22  
    11 SIMAP similar genes for SCUBE1 using alignment to 5 protein entries:     SCUB1_HUMAN (see all proteins):
    DKFZp686B09105    SCUBE2    DKFZp686D20108    SCUBE3    F9    PROS1
    PROC    NRP2    F7    NRP1    EFEMP1

    Find genes that share paralogs with SCUBE1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCUBE1 (see all 3709)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844326431,2
    --27514682(+) CAATTC/TAACCT 1 -- ds50010--------
    rs1389821,2
    C,F,A--27514700(+) TTATAG/AGAAGG 1 -- ds50015Minor allele frequency- A:0.13WA NA CSA 243
    rs1872365601,2
    --27514740(+) ATGGCA/GTAGCA 1 -- ds50010--------
    rs1487404391,2
    --27514759(+) CTGCAA/CTGGGA 1 -- ds50010--------
    rs72866881,2
    C,F,H--27514844(+) AGCCTG/TTGCTC 1 -- ds50017Minor allele frequency- T:0.05NS EA NA 426
    rs1490595381,2
    C--27514849(+) GTGCT-/CCTGTG 1 -- ds50010--------
    rs751159381,2
    C--27514893(+) TAGTAA/C/TGGACC 1 -- ds50010--------
    rs1512019331,2
    --27514894(+) AGTACA/GGACCC 1 -- ds50010--------
    rs1848095791,2
    --27514938(+) CCTTTC/TGCCGT 1 -- ds50010--------
    rs96237781,2
    C,F,H--27514975(+) GGAACG/CGGTCC 1 -- ds50015Minor allele frequency- C:0.06NS EA WA 538

    HapMap Linkage Disequilibrium report for SCUBE1 (43593289 - 43739394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SCUBE1 (see all 39):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724303CNV Deletion23290073
    esv1613247CNV Deletion17803354
    esv2665956CNV Deletion23128226
    esv2330845CNV Deletion18987734
    esv2628998CNV Deletion19546169
    nsv821331CNV Deletion20802225
    esv2724302CNV Deletion23290073
    esv2677156CNV Deletion23128226
    esv1076173CNV Deletion17803354
    esv2724301CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611746    OMIM disorders: --


    Find genes that share disorders with SCUBE1           About GenesLikeMe

    Genetic Association Database (GAD): SCUBE1
    Human Genome Epidemiology (HuGE) Navigator: SCUBE1 (1 document)

    Export disorders for SCUBE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCUBE1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SCUBE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1). (PubMed id 11087664)1, 3, 9 Grimmond S....Greenfield A. (Genomics 2000)
    2. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (Genes Immun. 2011)
    3. Localization and characterization of a novel secreted protein SCUBE1 in human platelets. (PubMed id 16753137)1, 2 Tu C.-F.... Yang R.-B. (Cardiovasc. Res. 2006)
    4. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. (PubMed id 12270931)1, 2 Yang R.-B.... Topper J.N. (J. Biol. Chem. 2002)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    6. Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH). (PubMed id 23918034)1 KA1hnisch J.... . (Clin Oral Investig 2014)
    7. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    8. Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1. (PubMed id 23136397)1 Orr B....Thomson A.A. (amp 2013)
    9. Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. (PubMed id 23149075)1 Aslibekyan S....Arnett D.K. (Nutr Metab Cardiovasc Dis 2013)
    10. Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level. (PubMed id 22874483)1 Ulusoy S....SA1mer A.U. (Clin. Biochem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80274 HGNC: 13441 AceView: SCUBE1 Ensembl:ENSG00000159307 euGenes: HUgn80274
    ECgene: SCUBE1 H-InvDB: SCUBE1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCUBE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCUBE1 gene:
    Search GeneIP for patents involving SCUBE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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