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Aliases for SCUBE1 Gene

Aliases for SCUBE1 Gene

  • Signal Peptide, CUB Domain, EGF-Like 1 2 3

External Ids for SCUBE1 Gene

Summaries for SCUBE1 Gene

Entrez Gene Summary for SCUBE1 Gene

  • This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]

GeneCards Summary for SCUBE1 Gene

SCUBE1 (Signal Peptide, CUB Domain, EGF-Like 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is LTBP3.

UniProtKB/Swiss-Prot for SCUBE1 Gene

  • Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCUBE1 Gene

Genomics for SCUBE1 Gene

Genomic Location for SCUBE1 Gene

Start:
43,197,283 bp from pter
End:
43,343,388 bp from pter
Size:
146,106 bases
Orientation:
Minus strand

Genomic View for SCUBE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCUBE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCUBE1 Gene

Regulatory Elements for SCUBE1 Gene

Proteins for SCUBE1 Gene

  • Protein details for SCUBE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWY4-SCUB1_HUMAN
    Recommended name:
    Signal peptide, CUB and EGF-like domain-containing protein 1
    Protein Accession:
    Q8IWY4
    Secondary Accessions:
    • Q5R336

    Protein attributes for SCUBE1 Gene

    Size:
    988 amino acids
    Molecular mass:
    107910 Da
    Quaternary structure:
    • Forms homooligomers and heterooligomers with SCUBE2 and SCUBE3.

neXtProt entry for SCUBE1 Gene

Proteomics data for SCUBE1 Gene at MOPED

Post-translational modifications for SCUBE1 Gene

Other Protein References for SCUBE1 Gene

No data available for DME Specific Peptides for SCUBE1 Gene

Domains for SCUBE1 Gene

UniProtKB/Swiss-Prot:

SCUB1_HUMAN
Domain:
  • Contains 1 CUB domain.:
    • Q8IWY4
  • Contains 9 EGF-like domains.:
    • Q8IWY4
genes like me logo Genes that share domains with SCUBE1: view

No data available for Gene Families for SCUBE1 Gene

Function for SCUBE1 Gene

Molecular function for SCUBE1 Gene

UniProtKB/Swiss-Prot Function: Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
UniProtKB/Swiss-Prot Induction: Down-regulated by inflammatory cytokines

Gene Ontology (GO) - Molecular Function for SCUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding TAS 12270931
GO:0005515 protein binding --
GO:0042802 identical protein binding IDA 12270931
GO:0046982 protein heterodimerization activity IDA 12270931
genes like me logo Genes that share ontologies with SCUBE1: view
genes like me logo Genes that share phenotypes with SCUBE1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SCUBE1 Gene

Localization for SCUBE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCUBE1 Gene

Secreted. Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCUBE1 Gene COMPARTMENTS Subcellular localization image for SCUBE1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SCUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 12270931
GO:0009897 external side of plasma membrane IDA 12270931
GO:0009986 cell surface IDA 12270931
GO:0019897 extrinsic component of plasma membrane IDA 12270931
genes like me logo Genes that share ontologies with SCUBE1: view

Pathways for SCUBE1 Gene

SuperPathways for SCUBE1 Gene

No Data Available

Interacting Proteins for SCUBE1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354080%0d%0a9606.ENSP00000429969%0d%0a9606.ENSP00000274938%0d%0a
Selected Interacting proteins: ENSP00000354080 Q8IWY4-SCUB1_HUMAN for SCUBE1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SCUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response NAS 12270931
GO:0007512 adult heart development NAS 12270931
GO:0007596 blood coagulation NAS 12270931
GO:0009791 post-embryonic development NAS 12270931
GO:0045446 endothelial cell differentiation NAS 12270931
genes like me logo Genes that share ontologies with SCUBE1: view

No data available for Pathways by source for SCUBE1 Gene

Transcripts for SCUBE1 Gene

Unigene Clusters for SCUBE1 Gene

Signal peptide, CUB domain, EGF-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCUBE1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: - - - - - - -
SP3:

ExUns: 22 ^ 23a · 23b
SP1:
SP2:
SP3:

Relevant External Links for SCUBE1 Gene

GeneLoc Exon Structure for
SCUBE1
ECgene alternative splicing isoforms for
SCUBE1

Expression for SCUBE1 Gene

mRNA expression in normal human tissues for SCUBE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCUBE1 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (10.9), Esophagus - Muscularis (9.0), Nerve - Tibial (6.5), and Ovary (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCUBE1 Gene

SOURCE GeneReport for Unigene cluster for SCUBE1 Gene Hs.133995

mRNA Expression by UniProt/SwissProt for SCUBE1 Gene

Q8IWY4-SCUB1_HUMAN
Tissue specificity: Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques.
genes like me logo Genes that share expressions with SCUBE1: view

Orthologs for SCUBE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCUBE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCUBE1 36
  • 94.87 (n)
  • 93.8 (a)
cow
(Bos Taurus)
Mammalia SCUBE1 36
  • 90.06 (n)
  • 92.49 (a)
SCUBE1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCUBE1 36
  • 89.54 (n)
  • 92.57 (a)
SCUBE1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scube1 36
  • 88.02 (n)
  • 92 (a)
Scube1 16
Scube1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCUBE1 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCUBE1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scube1 36
  • 88.33 (n)
  • 92.41 (a)
chicken
(Gallus gallus)
Aves SCUBE1 36
  • 74.86 (n)
  • 85.58 (a)
SCUBE1 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCUBE1 37
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15105 36
tropical clawed frog
(Silurana tropicalis)
Amphibia scube1 36
  • 75.91 (n)
  • 82.25 (a)
zebrafish
(Danio rerio)
Actinopterygii scube1 36
  • 71.41 (n)
  • 77.74 (a)
zgc:158328 37
  • 24 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32373 37
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToMany
Species with no ortholog for SCUBE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCUBE1 Gene

ENSEMBL:
Gene Tree for SCUBE1 (if available)
TreeFam:
Gene Tree for SCUBE1 (if available)

Paralogs for SCUBE1 Gene

Selected SIMAP similar genes for SCUBE1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SCUBE1: view

Variants for SCUBE1 Gene

Sequence variations from dbSNP and Humsavar for SCUBE1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs6482 -- 43,206,657(+) AGAAG(-/AA/AAG)GGGCC intron-variant
rs53724 -- 43,251,948(-) TTACC(C/T)CAGGC intron-variant
rs86625 -- 43,208,767(-) GCTGC(C/T)GCACT intron-variant
rs129414 -- 43,227,347(+) GGAGG(A/G)GCCAG intron-variant
rs129415 - 43,227,389(+) CTTCC(C/G)GTTCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for SCUBE1 Gene

Variant ID Type Subtype PubMed ID
nsv834214 CNV Gain 17160897
esv33816 CNV Gain 17666407
nsv915201 CNV Loss 21882294
dgv4988n71 CNV Loss 21882294
nsv520927 CNV Loss 19592680
dgv4990n71 CNV Loss 21882294
dgv4991n71 CNV Loss 21882294
nsv471201 CNV Loss 18288195
nsv834216 CNV Loss 17160897
nsv915226 CNV Loss 21882294
dgv4992n71 CNV Loss 21882294
nsv191393 CNV Insertion 16902084
esv2724301 CNV Deletion 23290073
esv2676917 CNV Deletion 23128226
esv2724302 CNV Deletion 23290073
esv5307 CNV Deletion 18987735
esv2724303 CNV Deletion 23290073
esv2660751 CNV Deletion 23128226
dgv4993n71 CNV Loss 21882294
esv269389 CNV Insertion 20981092
dgv4994n71 CNV Loss 21882294
esv268558 CNV Insertion 20981092
esv270288 CNV Insertion 20981092
nsv459891 CNV Gain 19166990
nsv471202 CNV Gain 18288195
esv2330845 CNV Deletion 18987734
esv2628998 CNV Deletion 19546169
esv2677156 CNV Deletion 23128226
esv29705 CNV Gain 19812545
nsv821331 CNV Deletion 20802225
esv2215307 CNV Deletion 18987734
esv3472 CNV Deletion 18987735
dgv782e201 CNV Deletion 23290073
esv2724305 CNV Deletion 23290073
esv1076173 CNV Deletion 17803354
esv1613247 CNV Deletion 17803354
esv1000890 CNV Deletion 20482838
dgv4995n71 CNV Loss 21882294
esv2665956 CNV Deletion 23128226

Relevant External Links for SCUBE1 Gene

HapMap Linkage Disequilibrium report
SCUBE1

Disorders for SCUBE1 Gene

Relevant External Links for SCUBE1

Genetic Association Database (GAD)
SCUBE1
Human Genome Epidemiology (HuGE) Navigator
SCUBE1
genes like me logo Genes that share disorders with SCUBE1: view

No data available for UniProtKB/Swiss-Prot for SCUBE1 Gene

Publications for SCUBE1 Gene

  1. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1). (PMID: 11087664) Grimmond S. … Greenfield A. (Genomics 2000) 2 3 23
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  3. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. (PMID: 12270931) Yang R.-B. … Topper J.N. (J. Biol. Chem. 2002) 3 4
  4. Localization and characterization of a novel secreted protein SCUBE1 in human platelets. (PMID: 16753137) Tu C.-F. … Yang R.-B. (Cardiovasc. Res. 2006) 3 4
  5. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PMID: 20962850) Budarf M.L. … Rioux J.D. (Genes Immun. 2011) 3 49

Products for SCUBE1 Gene

  • antibodies-online peptides for SCUBE1
  • antibodies-online antibodies for SCUBE1
  • antibodies-online kits for SCUBE1

Sources for SCUBE1 Gene

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