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Aliases & Descriptions for SCTR
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| pancreatic secretin receptor 2 | | secretin receptor 2 |
|
| | Search outside databases for aliases for SCTR genePrevious GC identifers: GC02M117402 GC02M118118 GC02M120104 GC02M120292 |
Summaries for SCTR(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for SCTR: The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq] UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872Function: This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclaseGene Wiki entry for SCTR (Secretin_receptor) |
Genomic Location for SCTR
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q14.1 Ensembl cytogenetic band: 2q14.2 HGNC cytogenetic band: 2q14.1SCTR Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M119913:
(about GC identifiers)
Start:
|
119,913,889 bp from pter |
End:
|
119,998,537 bp from pter |
Size:
|
84,649 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022135.15
| Proteins for SCTR
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872 (See
protein sequence)Recommended Name: Secretin receptor precursor Size: 440 amino acids; 50207 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q12961 Q13213REFSEQ proteins: NP_002971.2
ENSEMBL proteins: ENSP00000019103
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for SCTR: Assays for SCTR: | Protein
Domains/ Families for SCTR(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P47872
ProtoNet protein and cluster: P47872 2 Blocks protein families: IPB000832 G-protein coupled receptors family 2 (secretin-like) IPB002144 Secretin receptor signature
UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872Similarity: Belongs to the G-protein coupled receptor 2 family | Gene Function for SCTR
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002980
Applied Biosystems Silencer® siRNAs for SCTR
Sigma-Aldrich siRNA and siRNA Panels for SCTR  Sigma-Aldrich shRNA Panels and shRNA for SCTR  Explore Sigma-Aldrich super-pooled esiRNAs 
| Clones: |  | Invitrogen Clones for SCTR | |  | Millipore Clones for the Expression of SCTR |               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002980                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002980                                  untagged cDNA clone in CMV expression vector: NM_002980 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002980
UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872Function: This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclaseGenatlas biochemistry entry for SCTR:secretin receptor,G protein coupled receptor superfamily,potent regulator of pancreatic secretion5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sctr):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015055 | secretin receptor activity |
TAS | 7612008 | About this table | Pathways & Interactions for SCTR
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for SCTR 
5/14 Interacting proteins for SCTR (ENSP000000191033 P478722) via UniProtKB, MINT, and/or STRING (see all 14
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for SCTR(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for SCTR available from Tocris Bioscience 4 Novoseek chemical compound relationships for SCTR gene
About this table
|
Transcripts for SCTR(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002980
Sigma-Aldrich siRNA and siRNA Panels for SCTR  Sigma-Aldrich shRNA Panels and shRNA for SCTR  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002980 REFSEQ mRNAs for SCTR gene: NM_002980.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002980               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002980                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002980                                  untagged cDNA clone in CMV expression vector: NM_002980  Additional cDNA sequence: AK055551.1 AK091967.1 AK314638.1 AY462218.1 BC035757.1 U13989.1 U20178.1 U28281.1 6 DOTS entries: DT.95365980 DT.65287963 DT.107592 DT.91754929 DT.40282207 DT.75166693 24/33 AceView cDNA sequences (see all 33
):AY462218 AK055551 AI457773 BE328849 BC035757 AW770706 U13989 AI690192 AW135988 U20178 BI759935 U28281 BM998475 AW204280 BM925683 BF874694 AI922679 AI631007 BE218766 AK091967 BE550244 AW275970 AW135307 AI279066
highest scoring ESTs for SCTR:U28281 AY462218 BC035757 BM925683 U13989 U20178 AA975927 AI279066 AI631007 AI912064 Unigene Cluster for SCTR: Secretin receptor Hs.42091 [show with all ESTs]Unigene Representative Sequence: AK055551
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for SCTR
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for SCTR
1 Ensembl transcript including schematic representation: ENST00000019103
|
Expression for SCTR
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SCTR expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SCTR
1 / 2 / 3 3 probe-sets matching SCTR gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GACAGAGACC
SOURCE GeneReport for Unigene cluster: Hs.42091
Expression variation in blood from EXPOLDB for SCTR |
Orthologs for SCTR
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SCTR gene from 5/6 species (see all 6
)
About this table Species with no ortholog for SCTR
ENSEMBL Gene Tree for SCTR | Paralogs for SCTR(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for SCTR gene
- GLP1R2 GCGR2 GLP2R2 GIPR2
|
SNPs/Variants for SCTR(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SCTR (up to first 250kb)
|
Disorders & Mutations for SCTR
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 182098
7 Novoseek disease relationships for SCTR gene
About this table
|
Medical News for SCTR(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SCTR (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/121 PubMed articles for SCTR gene (see all 121
):- Molecular cloning and functional characterization of a human secretin receptor. (PubMed id 7612008)1, 3, 4 Chow B.K.-C. (1995)
- Molecular cloning and functional expression of a human pancreatic secretin receptor. (PubMed id 7864894)1, 3, 4 Jiang S. and Ulrich C.D. (1995)
- Molecular cloning and expression of a human secretin receptor. (PubMed id 7700244)1, 3, 4 Patel D.R.... Sreedharan S.P. (1995)
- Molecular cloning and expression of a cDNA encoding the secretin receptor. (PubMed id 1646711)2, 3 Ishihara T....Nagata S. (1991)
- Secretin-receptor and secretin-receptor-variant expression in gastrinomas: correlation with clinical and tumoral features and secretin and calcium provocative test results. (PubMed id 17711922)1, 3 Long S.H....Jensen R.T. (2007)
- Wild-type and splice-variant secretin receptors in lung cancer: overexpression in carcinoid tumors and peritumoral lung tissue. (PubMed id 18223557)1, 3 Korner M.U....Reubi J.C. (2008)
- Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. (PubMed id 16935383)1, 3 Korner M....Reubi J.C. (2006)
- Secretin receptors in normal and diseased human pancreas: marked reduction of receptor binding in ductal neoplasia. (PubMed id 16192632)1, 3 Korner M....Reubi J.C. (2005)
- A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor. (PubMed id 9506976)1, 3 Shetzline M.A....Caron M.G. (1998)
- Dimerization in the absence of higher-order oligomerization of the G protein-coupled secretin receptor. (PubMed id 18680717)1, 3 Harikumar K.G....Miller L.J. (2008)
|
Search for SCTR
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SCTR
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SCTR
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCTR(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SCTR(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SCTR:

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| | Recombinant Proteins (SCTR) | | Antibodies (SCTR) |
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Incremental update: 13 Oct 2009
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