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SCTR Gene

protein-coding   GIFtS: 63

GC02M119913
secretin receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
SCT-R 3
SR 2
Descriptions
pancreatic secretin receptor 2
secretin receptor 2
External Ids
HGNC: 106081
Entrez Gene: 63442
UniProtKB: P478723
Ensembl: ENSG000000802937
Search outside databases for aliases for SCTR gene

Previous GC identifers: GC02M117402 GC02M118118 GC02M120104 GC02M120292

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for SCTR:
The protein encoded by this gene is a G protein-coupled receptor and belongs to the
glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of
pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested
to be involved in pancreatic cancer and autism. [provided by RefSeq]

UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872
Function: This is a receptor for secretin. The activity of this receptor is mediated by G proteins
which activate adenylyl cyclase

Gene Wiki entry for SCTR (Secretin_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.1   Ensembl cytogenetic band:  2q14.2   HGNC cytogenetic band: 2q14.1

SCTR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M119913:     (about GC identifiers)

Start:
119,913,889 bp from pter
End:
119,998,537 bp from pter
Size:
84,649 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.10  NT_022135.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872 (See protein sequence)
Recommended Name: Secretin receptor precursor  
Size: 440 amino acids; 50207 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q12961 Q13213

REFSEQ proteins: NP_002971.2  

ENSEMBL proteins: 
ENSP00000019103 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Millipore Purified and/or Recombinant SCTR Protein
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (SCTR)
Human Recombinant Proteins from Abnova (SCTR)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IEA--
GO:0005887 integral to plasma membrane TAS7612008
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Antibodies for SCTR: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for SCTR
Browse R&D Systems for Antibodies
Antibodies from Abcam (SCTR), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (SCTR)
Novus Biologicals Antibodies for SCTR

Assays for SCTR: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR017983 GPCR_2_secretin-like_CS
 IPR001879 GPCR_2_extracellular
 IPR017981 GPCR_2-like
 IPR000832 GPCR_2_secretin-like
 IPR002144 GPCR_2_secretin_rcpt


   GeneDecks  SCTR for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P47872

ProtoNet protein and cluster: P47872

2 Blocks protein families:
IPB000832 G-protein coupled receptors family 2 (secretin-like)
IPB002144 Secretin receptor signature


UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872
Similarity: Belongs to the G-protein coupled receptor 2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (SCTR)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (SCTR)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002980

              Applied Biosystems Silencer® siRNAs for SCTR

              Sigma-Aldrich siRNA and siRNA Panels for SCTR  
                     Sigma-Aldrich shRNA Panels and shRNA for SCTR  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for SCTR
Millipore Clones for the Expression of SCTR
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002980
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002980
                                 untagged cDNA clone in CMV expression vector: NM_002980 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_002980

UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872
Function: This is a receptor for secretin. The activity of this receptor is mediated by G proteins
which activate adenylyl cyclase

Genatlas biochemistry entry for SCTR:
secretin receptor,G protein coupled receptor superfamily,potent regulator of pancreatic secretion

5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sctr):

behavior/neurologicalhematopoietic systemhomeostasis/metabolismimmune systemrenal/urinary system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0015055 secretin receptor activity TAS7612008
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Kegg Pathway  (Kegg details for SCTR):
 hsa04080 Neuroactive ligand-receptor interaction

   GeneDecks  SCTR for the pathways selected above  
About GeneDecksing
 Gene Network CentralTM Interacting Genes and Proteins Network for  SCTR 


5/14 Interacting proteins for SCTR (ENSP000000191033 P478722) via UniProtKB, MINT, and/or STRING (see all 14 )
InteractantInteraction Details
GeneCardExternal ID(s)
CALM1P621582MINT-51642
CALM2P621582MINT-51642
CALM3P621582MINT-51642
SCTENSP000001761953STRING (score=.985)
VIPENSP000003562133STRING (score=.98)
About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007186 G-protein coupled receptor protein signaling pathway TAS7612008
GO:0007586 digestion TAS7612008
GO:0007588 excretion TAS7612008
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Compounds for SCTR available from Tocris Bioscience
4 Novoseek chemical compound relationships for SCTR gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
l-bpa 77.37 2 12695527 (1), 11193860 (1)
bicarbonate 52.19 5 9277433 (2), 14645499 (1), 9176215 (1), 9626762 (1)
cyclic amp 37.87 4 9277433 (1), 8928798 (1), 19204666 (1)
calcium 0.00 1 17711922 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (SCTR)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (SCTR)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002980

              Sigma-Aldrich siRNA and siRNA Panels for SCTR  
                     Sigma-Aldrich shRNA Panels and shRNA for SCTR  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_002980  

REFSEQ mRNAs for SCTR gene: 

NM_002980.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_002980  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002980
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002980
                                 untagged cDNA clone in CMV expression vector: NM_002980 

Additional cDNA sequence: 

AK055551.1 AK091967.1 AK314638.1 AY462218.1 BC035757.1 U13989.1 U20178.1 U28281.1 

6 DOTS entries:

DT.95365980  DT.65287963  DT.107592  DT.91754929  DT.40282207  DT.75166693 

24/33 AceView cDNA sequences (see all 33 ):

AY462218 AK055551 AI457773 BE328849 BC035757 AW770706 U13989 AI690192 
AW135988 U20178 BI759935 U28281 BM998475 AW204280 BM925683 BF874694 
AI922679 AI631007 BE218766 AK091967 BE550244 AW275970 AW135307 AI279066 

highest scoring ESTs for SCTR:

U28281 AY462218 BC035757 BM925683 U13989 U20178 AA975927 AI279066 AI631007 AI912064 

Unigene Cluster for SCTR:

Secretin receptor
Hs.42091  [show with all ESTs]
Unigene Representative Sequence: AK055551


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SCTR

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:              -                                                                     
SP2:                                -                                                   

About this scheme

ECgene alternative splicing isoforms for SCTR

1 Ensembl transcript including schematic representation:
ENST00000019103  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SCTR expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for SCTR

1 / 2 / 3

3 probe-sets matching SCTR gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
32902_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U28281 1.00 1.00 1.00 1

210382_at2, 3 U133-A 1 1.00 1.00 -- -- U13989 0.80 1.00 0.91 1

210382_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  SCTR for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GACAGAGACC

SOURCE GeneReport for Unigene cluster: Hs.42091

Expression variation in blood from EXPOLDB for SCTR

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for SCTR gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
SCTR1   -- secretin receptor 87.82(n)
86.89(a)
483883  XM_541003.2  XP_541003.2 
chimpanzee
(Pan troglodytes)
SCTR1   -- secretin receptor 99.24(n)
99.09(a)
459576  XM_515761.2  XP_515761.2 
cow
(Bos taurus)
SCTR1   -- secretin receptor 87.4(n)
87.07(a)
523291  XM_601587.3  XP_601587.3 
rat
(Rattus norvegicus)
Sctr1   -- secretin receptor 83.91(n)
82.99(a)
81779  NM_031115.1  NP_112377.1 
mouse
(Mus musculus)
Sctr5 1 secretin receptor   -- BC089355 
About this table        Species with no ortholog for SCTR

ENSEMBL Gene Tree for SCTR
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for SCTR gene
GLP1R2  GCGR2  GLP2R2  GIPR2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/651 NCBI SNPs in SCTR are shown (see all 651 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 210)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs19922481,2
A,C,F,H119999643(+) AACAAA/TGTGTT 1 -- ng3112Minor allele frequency- T:0.39EU EA WA NA 1198
rs10426561,2
A,C,F,H119914140(-) ACCCAT/CGGACA 1 -- ut31 ese39Minor allele frequency- C:0.33EA MN NA EU WA 2232
rs37316001,2
C,F,H119947540(-) ATCTGG/CCCTGT 1 P/A mis1 ese38Minor allele frequency- C:0.01EU EA WA 840
rs20438681,2
A,C,F120000045(+) ACGCAT/AGCATG 1 -- ng314Minor allele frequency- A:0.35NA EA 362
rs67264911,2
C,F,H119947576(+) GCCATC/TCTGTG 1 D/N mis1 ese38Minor allele frequency- T:0.01EU EA WA 826
rs22442141,2
A,C119998485(+) TTGATC/TAGGAC 1 -- ut51 ese30--------
rs38064931,2
F,H119999755(-) CATTGG/ATTTTG 1 -- ng315Minor allele frequency- A:0.01EA EU WA 1908
--
rs22442131,2
A,C119998496(+) GCGGCG/TTTGCC 1 -- ut510--------
--
rs19922471,2
C119999453(+) ctcccC/Tcacac 1 -- ng310--------
rs25876901,2
C119998947(-) AGGAGC/TTCATG 1 -- ng310--------
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HapMap Linkage Disequilibrium images for SCTR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 182098

7 Novoseek disease relationships for SCTR gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
gastrinoma 58.15 6 17711922 (3), 9071943 (1), 17684767 (1), 11832464 (1)
pancreatic cancer 29.84 1 17678920 (1)
autistic 17.80 1 11890683 (1)
cystic fibrosis 14.83 4 12360418 (1), 19204666 (1)
adenocarcinoma 7.53 4 8895485 (1), 8656026 (1), 16192632 (1), 7612008 (1)
carcinoma 0.00 1 18223557 (1)
tumors 0.00 12 16192632 (4), 18223557 (3), 17711922 (2)
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(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/121 PubMed articles for SCTR gene (see all 121 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Search String
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6344 HGNC: 10608 AceView: SCTR Ensembl:ENSG00000080293 euGenes: HUgn6344
ECgene: SCTR H-InvDB: SCTR
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for SCTR Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for SCTR:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SCTR-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
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 Predesigned and custom siRNAs for SCTR Antibodies for SCTR
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for SCTR Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(SCTR)
 Antibodies (SCTR)
 Search OriGene for SCTR
 Tocris compounds for SCTR




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for SCTR

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