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SCTR Gene

protein-coding   GIFtS: 63
GCID: GC02M120292

Secretin Receptor

  See SCTR-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secretin Receptor1 2
SR2
Pancreatic Secretin Receptor2
SCT-R3

External Ids:    HGNC: 106081   Entrez Gene: 63442   Ensembl: ENSG000000802937   OMIM: 1820985   UniProtKB: P478723   

Export aliases for SCTR gene to outside databases

Previous GC identifers: GC02M117402 GC02M118118 GC02M120104 GC02M119913 GC02M112522


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCTR Gene:
The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor
family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume
secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SCTR Gene:
SCTR (secretin receptor) is a protein-coding gene. Diseases associated with SCTR include pancreatic cancer. GO annotations related to this gene include secretin receptor activity. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872
Function: This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate
adenylyl cyclase

summary for SCTR Gene:
Secretin receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, GLP-2,
GHRH and GIP receptors. Secretin receptors are classically localized to the epithelial cells within the
pancreatic and biliary ducts, where they stimulate the release of alkaline bicarbonate-rich fluid to
neutralise acidic chyme from the stomach. This protects the duodenal mucosa and provides an optimal
intraluminal environment for digestion to take place. Secretin receptors are also found in the CNS, where
they are thought to play a role in the regulation of the hypothalamic-pituitary-axis (HPA) axis. The human
secretin receptor gene is localized on chromosome 2p14.1.

Gene Wiki entry for SCTR (Secretin receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SCTR
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCTR promoter sequence
   Search Chromatin IP Primers for SCTR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCTR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.1   Ensembl cytogenetic band:  2q14.2   HGNC cytogenetic band: 2q14.1

SCTR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCTR gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M120292:  view genomic region     (about GC identifiers)

Start:
120,197,419 bp from pter      End:
120,282,070 bp from pter
Size:
84,652 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872 (See protein sequence)
Recommended Name: Secretin receptor precursor  
Size: 440 amino acids; 50207 Da
Secondary accessions: Q12961 Q13213 Q53T00

Explore the universe of human proteins at neXtProt for SCTR: NX_P47872

Explore proteomics data for SCTR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn72, Asn100, Asn106, Asn128, Asn291

  • See SCTR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002971.2  
    ENSEMBL proteins: 
     ENSP00000019103  
    Reactome Protein details: P47872

    SCTR Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SCTR

     
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    antibodies-online proteins for SCTR (5 products) 

     
    antibodies-online peptides for SCTR

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    antibodies-online antibodies for SCTR (47 products) 

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    antibodies-online kits for SCTR (25 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GCGR: GPCR / Class B : Glucagon receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: secretin receptor
    Glucagon receptor family

    5 InterPro protein domains:
     IPR001879 GPCR_2_extracellular_dom
     IPR000832 GPCR_2_secretin-like
     IPR002144 GPCR_2_secretin_rcpt
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry P47872

    ProtoNet protein and cluster: P47872

    2 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB002144 Secretin receptor signature


    UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Find genes that share domains with SCTR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCTR_HUMAN, P47872
    Function: This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate
    adenylyl cyclase

         Genatlas biochemistry entry for SCTR:
    secretin receptor,G protein coupled receptor superfamily,potent regulator of pancreatic secretion

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity ----
    GO:0015055secretin receptor activity TAS7612008
         
    Find genes that share ontologies with SCTR           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SCTR:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sctr):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  renal/urinary system 

    Find genes that share phenotypes with SCTR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sctrtm1Bkcc for SCTR

       genOway: Develop your customized and physiologically relevant rodent model for SCTR

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCTR_HUMAN, P47872: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    extracellular2
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005881cytoplasmic microtubule IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7612008
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SCTR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SCTR About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3ADP signalling through P2Y purinoceptor 12
    Glucagon-type ligand receptors0.61
    Class B/2 (Secretin family receptors)0.36
    4Pancreatic secretion
    Pancreatic secretion
    5GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like


    Find genes that share SuperPaths with SCTR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SCTR
        GPCRs, Class B Secretin-like

    2 Reactome Pathways for SCTR
        Glucagon-type ligand receptors
    G alpha (s) signalling events


    3 Kegg Pathways  (Kegg details for SCTR):
        Neuroactive ligand-receptor interaction
    Pancreatic secretion
    Bile secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SCTR: 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SCTR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SCTR (P478722, 3 ENSP000000191034) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-51642 I2D: score=3 
    CALM3P621582, 3MINT-51642 I2D: score=3 
    CALM1P621582, 3, ENSP000003494674MINT-51642 I2D: score=3 STRING: ENSP00000349467
    CPAMD8Q8IZJ33, ENSP000002914404I2D: score=2 STRING: ENSP00000291440
    PRKAR2AP138613, ENSP000002655634I2D: score=1 STRING: ENSP00000265563
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS7612008
    GO:0007586digestion TAS7612008
    GO:0007588excretion TAS7612008

    Find genes that share ontologies with SCTR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SCTR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Secretin (human)Gastrointestinal peptide[108153-74-8]
    Secretin (rat)Gastrointestinal peptide[121028-49-7]

    1 DrugBank Compound for SCTR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Secretin-- --targetagonist17139284 11752352 17016423

    4 IUPHAR Ligands for SCTR (secretin receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    secretin
    AgonistFull agonist9.77612008
    VIP
    AgonistPartial agonist5.41646711
    [(CH2NH)4,5]secretin
    AntagonistAntagonist5.31702423
    [125I](Tyr10)secretin
    NoneNone5.3--

    7 Novoseek inferred chemical compound relationships for SCTR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    l-bpa 76.5 2 12695527 (1), 11193860 (1)
    adenylate 62.1 7 2171930 (2), 9605937 (1), 10022611 (1), 11853547 (1) (see all 6)
    bicarbonate 50.6 5 9277433 (2), 14645499 (1), 9176215 (1), 9626762 (1)
    cyclic amp 36.5 4 9277433 (1), 8928798 (1), 19204666 (1)
    cysteine 21.7 2 17635130 (1), 15664984 (1)
    calcium 0 2 17711922 (1), 19886671 (1)
    acetylcholine 0 1 15689674 (1)



    Find genes that share compounds with SCTR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCTR gene: 
    NM_002980.2  

    Unigene Cluster for SCTR:

    Secretin receptor
    Hs.42091  [show with all ESTs]
    Unigene Representative Sequence: AK055551
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000019103(uc002tma.3) ENST00000494326 ENST00000485440(uc002tlz.3)

    miRNA
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    Additional mRNA sequence: 

    AK055551.1 AK091967.1 AK314638.1 AY462218.1 BC035757.1 U13989.1 U20178.1 U28281.1 

    6 DOTS entries:

    DT.95365980  DT.107592  DT.91754929  DT.40282207  DT.65287963  DT.75166693 

    Selected AceView cDNA sequences (see all 33):

    AY462218 AK055551 AI457773 AI631007 AI912064 AW204280 AK091967 NM_002980 
    U13989 AI279066 AW135307 AW275970 BI759935 AW135988 BF874694 AW770706 
    BE550244 BM925683 BV203239 BE218766 AA975927 AI690192 BM998475 BE328849 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SCTR    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:              -                                                                     
    SP2:                                -                                                   


    ECgene alternative splicing isoforms for SCTR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCTR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAGAGACC
    SCTR Expression
    About this image

    SCTR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCTR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.42091
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SCTR: 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SCTR
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    QuantiFast Probe-based Assays in human, mouse, rat SCTR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCTR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SCTR gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sctr1 , 5 secretin receptor1, 5 84.09(n)1
    81.86(a)1
      1 (52.57 cM)5
    3192291  NM_001012322.21  NP_001012322.21 
     1200069805 
    chicken
    (Gallus gallus)
    Aves SCTR1 secretin receptor 64.8(n)
    63.5(a)
      770943  NM_001171542.1  NP_001165013.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCTR6
    secretin receptor
    47(a)
    1 ↔ 1
    GL343497.1(81367-123349)
    zebrafish
    (Danio rerio)
    Actinopterygii sctr1 secretin receptor 57.32(n)
    46.3(a)
      100537567  NM_001256639.1  NP_001243568.1 


    ENSEMBL Gene Tree for SCTR (if available)
    TreeFam Gene Tree for SCTR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCTR gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  CRHR22  VIPR12  CRHR12  
    PTH2R2  CALCRL2  ADCYAP1R12  GLP2R2  VIPR22  GIPR2  
    15 SIMAP similar genes for SCTR using alignment to 2 protein entries:     SCTR_HUMAN (see all proteins):
    VIPR2    VIPR1    GHRHR    GLP2R    ADCYAP1R1    GLP1R
    PTH1R    GIPR    CRHR2    CRHR1    PTH2R    GCGR
    CALCRL    PTHR2    CALCR

    Find genes that share paralogs with SCTR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCTR (see all 2081)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503692241,2
    --112526736(+) TATATA/TCGTAT 1 -- int10--------
    rs1432505161,2
    C--112526772(+) TATAT-/ACACATA 1 -- int10--------
    rs2017329771,2
    C--112526787(+) GTATGA/TATATA 1 -- int10--------
    rs1844052591,2
    --112526795(+) ATATAC/TACACA 1 -- int10--------
    rs1896753411,2
    C--112526798(+) TATACA/CCATAT 1 -- int10--------
    rs1811079681,2
    --112526805(+) ATATAC/TGTATG 1 -- int10--------
    rs1490752031,2
    --112526817(+) ATATAC/TATACC 1 -- int10--------
    rs1860007551,2
    --112526828(+) CATATA/TCGTAT 1 -- int10--------
    rs1912003951,2
    --112526830(+) TATACA/GTATGA 1 -- int10--------
    rs3747179051,2
    C--112526846(+) ATACA-/ATTATAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SCTR (120197419 - 120282070 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SCTR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720634CNV Deletion23290073
    nsv874964CNV Loss21882294
    nsv874961CNV Gain21882294
    nsv874963CNV Gain21882294
    nsv459119CNV Gain19166990
    nsv874962CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182098    OMIM disorders: --

    1 disease for SCTR:    
    About MalaCards
    pancreatic cancer


    Find genes that share disorders with SCTR           About GenesLikeMe

    8 Novoseek inferred disease relationships for SCTR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastrinoma 56.8 6 17711922 (3), 9071943 (1), 17684767 (1), 11832464 (1)
    pancreatic diseases 40.4 1 8656026 (1)
    pancreatic cancer 27.1 1 17678920 (1)
    autistic 15.2 1 11890683 (1)
    cystic fibrosis 12.6 4 12360418 (1), 19204666 (1)
    adenocarcinoma 5.12 5 8895485 (1), 8656026 (1), 16192632 (1), 7612008 (1)
    tumors 0 12 16192632 (4), 18223557 (3), 17711922 (2)
    carcinoma 0 1 18223557 (1)


    Export disorders for SCTR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCTR gene, integrated from 10 sources (see all 137):
    (articles sorted by number of sources associating them with SCTR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional characterization of a human secretin receptor. (PubMed id 7612008)1, 2, 9 Chow B.K.-C. (Biochem. Biophys. Res. Commun. 1995)
    2. Molecular cloning and functional expression of a human pancreatic secretin receptor. (PubMed id 7864894)1, 2, 9 Jiang S. and Ulrich C.D. (Biochem. Biophys. Res. Commun. 1995)
    3. Molecular cloning and expression of a human secretin receptor. (PubMed id 7700244)1, 2, 9 Patel D.R.... Sreedharan S.P. (Mol. Pharmacol. 1995)
    4. Molecular cloning and expression of a cDNA encoding the secretin receptor. (PubMed id 1646711)1, 3 Ishihara T....Nagata S. (EMBO J. 1991)
    5. Secretin-receptor and secretin-receptor-variant expression in gastrinomas: correlation with clinical and tumoral features and secretin and calcium provocative test results. (PubMed id 17711922)1, 9 Long S.H....Jensen R.T. (J. Clin. Endocrinol. Metab. 2007)
    6. Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor. (PubMed id 19904746)1, 9 Onori P....Glaser S.S. (Int. J. Cancer 2010)
    7. Wild-type and splice-variant secretin receptors in lung cancer: overexpression in carcinoid tumors and peritumoral lung tissue. (PubMed id 18223557)1, 9 KAPrner M.U....Reubi J.C. (Mod. Pathol. 2008)
    8. Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. (PubMed id 16935383)1, 9 KAPrner M....Reubi J.C. (J. Hepatol. 2006)
    9. Secretin receptors in normal and diseased human pancreas: marked reduction of receptor binding in ductal neoplasia. (PubMed id 16192632)1, 9 KAPrner M....Reubi J.C. (Am. J. Pathol. 2005)
    10. A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor. (PubMed id 9506976)1, 9 Shetzline M.A....Caron M.G. (J. Biol. Chem. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6344 HGNC: 10608 AceView: SCTR Ensembl:ENSG00000080293 euGenes: HUgn6344
    ECgene: SCTR Kegg: 6344 H-InvDB: SCTR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCTR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SCTR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SCTR gene:
    Search GeneIP for patents involving SCTR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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