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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCTR Gene

protein-coding   GIFtS: 62
GCID: GC02M120292

secretin receptor
 Explore 18 diseases affiliated with
SCTR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SCTR    

Aliases
for SCTR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Secretin Receptor1 2
SR2
Pancreatic Secretin Receptor2
SCT-R3

External Ids:    HGNC: 106081   Entrez Gene: 63442   Ensembl: ENSG000000802937   OMIM: 1820985   UniProtKB: P478723   

Export aliases for SCTR gene to outside databases

Previous GC identifers: GC02M117402 GC02M118118 GC02M120104 GC02M119913 GC02M112522


Summaries
for SCTR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SCTR:
The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor
family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume
secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872
Function: This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate
adenylyl cyclase

summary for SCTR:
Secretin receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, GLP-2,
GHRH and GIP receptors. Secretin receptors are classically localized to the epithelial cells within the
pancreatic and biliary ducts, where they stimulate the release of alkaline bicarbonate-rich fluid to
neutralise acidic chyme from the stomach. This protects the duodenal mucosa and provides an optimal
intraluminal environment for digestion to take place. Secretin receptors are also found in the CNS, where
they are thought to play a role in the regulation of the hypothalamic-pituitary-axis (HPA) axis. The human
secretin receptor gene is localized on chromosome 2p14.1.

Gene Wiki entry for SCTR (Secretin receptor)


Genomic Views
for SCTR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SCTR
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCTR promoter sequence
   Search SABiosciences Chromatin IP Primers for SCTR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCTR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.1   Ensembl cytogenetic band:  2q14.2   HGNC cytogenetic band: 2q14.1

SCTR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCTR gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M120292:  view genomic region     (about GC identifiers)

Start:
 120,197,419 bp from pter      End:
 120,282,070 bp from pter
Size:
 84,652 bases      Orientation:
 minus strand

Proteins
for SCTR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872 (See protein sequence)
Recommended Name: Secretin receptor precursor  
Size: 440 amino acids; 50207 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q12961 Q13213 Q53T00

Explore the universe of human proteins at neXtProt for SCTR: NX_P47872

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P47872

    • SCTR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002971.2  
    ENSEMBL proteins: 
     ENSP00000019103  
    Reactome Protein details: P47872
    Human Recombinant Protein Products: 
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    Novus Biologicals SCTR Proteins
    Novus Biologicals SCTR Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SCTR

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7612008


    SCTR for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SCTR

    Protein Domains /
    Families
    for SCTR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SCTR for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017983 GPCR_2_secretin-like_CS
     IPR001879 GPCR_2_extracellular_dom
     IPR017981 GPCR_2-like
     IPR000832 GPCR_2_secretin-like
     IPR002144 GPCR_2_secretin_rcpt

    Graphical View of Domain Structure for InterPro Entry P47872

    ProtoNet protein and cluster: P47872

    2 Blocks protein families:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB002144 Secretin receptor signature


    UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Function
    for SCTR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SCTR_HUMAN, P47872
    Function: This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate
    adenylyl cyclase

         Genatlas biochemistry entry for SCTR:
    secretin receptor,G protein coupled receptor superfamily,potent regulator of pancreatic secretion

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCTR
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    SwitchGear 3'UTR luciferase reporter plasmid: SCTR 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCTR (see all 7)
    OriGene shRNA RFP: SCTR
    OriGene siRNA: SCTR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCTR

    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015055secretin receptor activity TAS7612008


    SCTR for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SCTR:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Sctrtm1Bkcc for SCTR
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sctr):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  renal/urinary system 

    SCTR for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SCTR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    2G beta:gamma signalling through PLC beta
    		Glucagon-type ligand receptors0.52
    		G alpha (s) signalling events0.14
    		Class B/2 (Secretin family receptors)0.20
    3Class A/1 (Rhodopsin-like receptors)
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    4GPCRs, Class B Secretin-like
    		GPCRs, Class B Secretin-like1.00
    5Bile secretion
    		Bile secretion1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SCTR 
        GPCRs, Class B Secretin-like

    5/7        Reactome Pathways for SCTR (see all 7)
        GPCR downstream signaling
    Glucagon-type ligand receptors
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding


    3         Kegg Pathways  (Kegg details for SCTR):
        Neuroactive ligand-receptor interaction
    Pancreatic secretion
    Bile secretion


    SCTR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCTR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/74 Interacting proteins for SCTR (P478722, 3 ENSP000000191034) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-51642 I2D: score=3 
    CALM3P621582, 3MINT-51642 I2D: score=3 
    CALM1P621582, 3, ENSP000003494674MINT-51642 I2D: score=3 STRING: ENSP00000349467
    CPAMD8Q8IZJ33, ENSP000002914404I2D: score=2 STRING: ENSP00000291440
    PRKAR2AP138613, ENSP000002655634I2D: score=1 STRING: ENSP00000265563
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS7612008
    GO:0007586digestion TAS7612008
    GO:0007588excretion TAS7612008


    SCTR for ontologies           About GeneDecksing



    Drugs & Compounds
    for SCTR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCTR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SCTR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Demethylasterriquinone B1Selective insulin RTK activator[78860-34-1]
    Secretin (human)Gastrointestinal peptide[108153-74-8]

    1 DrugBank Compound for SCTR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Secretin-- --targetagonist17139284 11752352 17016423

    7 Novoseek chemical compound relationships for SCTR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    l-bpa 76.5 2 12695527 (1), 11193860 (1)
    adenylate 62.1 7 2171930 (2), 9605937 (1), 10022611 (1), 11853547 (1) (see all 6)
    bicarbonate 50.6 5 9277433 (2), 14645499 (1), 9176215 (1), 9626762 (1)
    cyclic amp 36.5 4 9277433 (1), 8928798 (1), 19204666 (1)
    cysteine 21.7 2 17635130 (1), 15664984 (1)
    calcium 0 2 17711922 (1), 19886671 (1)
    acetylcholine 0 1 15689674 (1)

    Search CenterWatch for drugs/clinical trials and news about SCTR 

    Transcripts
    for SCTR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SCTR gene: 
    NM_002980.2  

    Unigene Cluster for SCTR:

    Secretin receptor
    Hs.42091  [show with all ESTs]
    Unigene Representative Sequence: AK055551
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000019103(uc002tma.3) ENST00000494326 ENST00000485440(uc002tlz.3)


    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: SCTR 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCTR (see all 7)
    OriGene shRNA RFP: SCTR
    OriGene siRNA: SCTR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCTR
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK055551.1 AK091967.1 AK314638.1 AY462218.1 BC035757.1 U13989.1 U20178.1 U28281.1 

    6 DOTS entries:

    DT.95365980  DT.107592  DT.91754929  DT.40282207  DT.65287963  DT.75166693 

    24/33 AceView cDNA sequences (see all 33):

    AI457773 AK055551 AY462218 BE218766 AI922679 AW135307 BE550244 U28281 
    BC035757 BM998475 BV203239 U20178 AK091967 AW204280 NM_002980 AI631007 
    AW135988 BF874694 BM925683 AA975927 AW770706 BI759935 AI279066 AI912064 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SCTR    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:              -                                                                     
    SP2:                                -                                                   


    ECgene alternative splicing isoforms for SCTR

    Expression
    for SCTR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCTR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACAGAGACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SCTR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverIntrahepatic Biliary TreeBiliary Epithelial CellsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SCTR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCTR

    SOURCE GeneReport for Unigene cluster: Hs.42091
        SABiosciences Expression via Pathway-Focused PCR Arrays including SCTR: 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for SCTR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SCTR gene from 2/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SCTR1 secretin receptor 64.8(n)
    63.5(a)    		   770943  NM_001171542.1  NP_001165013.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    --
    (see all 4)    		 --
    		 3(a)
    26(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 Group9.2(517685-519657)
    GroupUn.2891(6917-15037)


    ENSEMBL Gene Tree for SCTR (if available)
    TreeFam Gene Tree for SCTR (if available) 

    Paralogs
    for SCTR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCTR gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  CRHR22  PTH1R2  VIPR12  CRHR12  
    PTH2R2  CALCRL2  ADCYAP1R12  GLP2R2  VIPR22  GIPR2  
    15 SIMAP similar genes for SCTR using alignment to 2 protein entries:     SCTR_HUMAN (see all proteins):
    VIPR2    VIPR1    GHRHR    GLP2R    GIPR    ADCYAP1R1
    GLP1R    PTH1R    CRHR2    CRHR1    PTH2R    GCGR
    CALCRL    PTHR2    CALCR

    SCTR for paralogs           About GeneDecksing



    Genomic Variants
    for SCTR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1760 NCBI SNPs in SCTR are shown (see all 1760)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs772934741,2
    		F,--112521893(+) CTTGGG/ACAAGT 1 -- ds50011Minor allele frequency- A:0.09WA 118
    rs576073371,2
    		--112522089(+) CCTCCG/TTGGTG 1 -- ds50010--------
    rs360291871,2
    		C,F--112522201(+) ATTTCC/ATGTTG 1 -- ds50012Minor allele frequency- A:0.50NA 4
    rs739486941,2
    		C,--112522211(+) GGCTGG/AGCCTT 1 -- ds50012Minor allele frequency- A:0.07WA 120
    rs794834521,2
    		F,--112522246(+) GCTGGG/AGGACC 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs739486951,2
    		C,--112522268(+) CGCCTC/TCTGCG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs739486961,2
    		C,--112522432(+) CCAAAT/CCCCAG 1 -- ut312Minor allele frequency- C:0.06WA 120
    rs1136825931,2
    		--112523198(+) GTGGGG/TAGGGC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs739486971,2
    		C,F,--112523815(+) GACCTA/GCAGAA 1 -- int13Minor allele frequency- G:0.11WA CSA 122
    rs739486981,2
    		C,F,--112523988(+) TCCCAG/CGTAGC 1 -- int13Minor allele frequency- C:0.10WA CSA 122

    HapMap Linkage Disequilibrium report for SCTR (120197419 - 120282070 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SCTR: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SCTR

    Disorders / Diseases
    for SCTR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SCTR for disorders           About GeneDecksing

    OMIM gene information: 182098    OMIM disorders: --

    18 diseases for SCTR:    About MalaCards
    pancreatitis    pancreatic cancer    duodenitis    gastrinoma
    cystic fibrosis    autistic disorder    carcinoid tumors    pancreatic diseases
    fibrosis    thyroid carcinoma    hepatocellular carcinoma    pancreatic carcinoma
    carcinoma    thyroiditis    cholangiocarcinoma    lung cancer
    adenocarcinoma    neuroblastoma

    8 Novoseek disease relationships for SCTR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastrinoma 56.8 6 17711922 (3), 9071943 (1), 17684767 (1), 11832464 (1)
    pancreatic diseases 40.4 1 8656026 (1)
    pancreatic cancer 27.1 1 17678920 (1)
    autistic 15.2 1 11890683 (1)
    cystic fibrosis 12.6 4 12360418 (1), 19204666 (1)
    adenocarcinoma 5.12 5 8895485 (1), 8656026 (1), 16192632 (1), 7612008 (1)
    tumors 0 12 16192632 (4), 18223557 (3), 17711922 (2)
    carcinoma 0 1 18223557 (1)


    Export disorders for SCTR gene to outside databases

    Publications
    for SCTR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCTR gene, integrated from 9 sources (see all 132):
    (articles sorted by number of sources associating them with SCTR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional characterization of a human secretin receptor. (PubMed id 7612008)1, 2, 9 Chow B.K.-C. (1995)
    2. Molecular cloning and functional expression of a human pancreatic secretin receptor. (PubMed id 7864894)1, 2, 9 Jiang S. and Ulrich C.D. (1995)
    3. Molecular cloning and expression of a human secretin receptor. (PubMed id 7700244)1, 2, 9 Patel D.R.... Sreedharan S.P. (1995)
    4. Molecular cloning and expression of a cDNA encoding the secretin receptor. (PubMed id 1646711)1, 3 Ishihara T....Nagata S. (1991)
    5. Secretin-receptor and secretin-receptor-variant expression in gastrinomas: correlation with clinical and tumoral features and secretin and calcium provocative test results. (PubMed id 17711922)1, 9 Long S.H....Jensen R.T. (2007)
    6. Secretin inhibits cholangiocarcinoma growth via dysre gulation of the cAMP-dependent signaling mechanisms of secretin receptor. (PubMed id 19904746)1, 9 Onori P....Glaser S.S. (2010)
    7. Wild-type and splice-variant secretin receptors in lung cancer: overexpression in carcinoid tumors and peritumoral lung tissue. (PubMed id 18223557)1, 9 Korner M.U....Reubi J.C. (2008)
    8. Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. (PubMed id 16935383)1, 9 Korner M....Reubi J.C. (2006)
    9. Secretin receptors in normal and diseased human pancreas: marked reduction of receptor binding in ductal neoplasia. (PubMed id 16192632)1, 9 Korner M....Reubi J.C. (2005)
    10. A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor. (PubMed id 9506976)1, 9 Shetzline M.A....Caron M.G. (1998)

    External Searches for SCTR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SCTR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6344 HGNC: 10608 AceView: SCTR Ensembl:ENSG00000080293 euGenes: HUgn6344
    ECgene: SCTR Kegg: 6344 H-InvDB: SCTR

    Other Databases showing SCTR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SCTR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCTR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SCTR Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SCTR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SCTR gene:
    Search GeneIP for patents involving SCTR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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