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Aliases for SCTR Gene

Aliases for SCTR Gene

  • Secretin Receptor 2 3
  • Pancreatic Secretin Receptor 3
  • SCT-R 4
  • SR 3

External Ids for SCTR Gene

Previous GeneCards Identifiers for SCTR Gene

  • GC02M117402
  • GC02M118118
  • GC02M120104
  • GC02M120292
  • GC02M119913
  • GC02M112522

Summaries for SCTR Gene

Entrez Gene Summary for SCTR Gene

  • The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCTR Gene

SCTR (Secretin Receptor) is a Protein Coding gene. Diseases associated with SCTR include pancreatic cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include secretin receptor activity. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for SCTR Gene

  • This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Tocris Summary for SCTR Gene

  • Secretin receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, GLP-2, GHRH and GIP receptors. Secretin receptors are classically localized to the epithelial cells within the pancreatic and biliary ducts, where they stimulate the release of alkaline bicarbonate-rich fluid to neutralise acidic chyme from the stomach. This protects the duodenal mucosa and provides an optimal intraluminal environment for digestion to take place. Secretin receptors are also found in the CNS, where they are thought to play a role in the regulation of the hypothalamic-pituitary-axis (HPA) axis. The human secretin receptor gene is localized on chromosome 2p14.1.

Gene Wiki entry for SCTR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCTR Gene

Genomics for SCTR Gene

Genomic Location for SCTR Gene

Start:
119,439,843 bp from pter
End:
119,524,494 bp from pter
Size:
84,652 bases
Orientation:
Minus strand

Genomic View for SCTR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCTR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCTR Gene

No data available for Regulatory Elements for SCTR Gene

Proteins for SCTR Gene

  • Protein details for SCTR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47872-SCTR_HUMAN
    Recommended name:
    Secretin receptor
    Protein Accession:
    P47872
    Secondary Accessions:
    • Q12961
    • Q13213
    • Q53T00

    Protein attributes for SCTR Gene

    Size:
    440 amino acids
    Molecular mass:
    50207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCTR Gene

Proteomics data for SCTR Gene at MOPED

Post-translational modifications for SCTR Gene

  • Glycosylation at Asn72, Asn100, Asn106, Asn128, and Asn291
  • Modification sites at PhosphoSitePlus

Other Protein References for SCTR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SCTR Gene

Domains for SCTR Gene

Gene Families for SCTR Gene

HGNC:
  • GCGR :GPCR / Class B : Glucagon receptors
IUPHAR :

Suggested Antigen Peptide Sequences for SCTR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47872

UniProtKB/Swiss-Prot:

SCTR_HUMAN :
  • P47872
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with SCTR: view

Function for SCTR Gene

Molecular function for SCTR Gene

GENATLAS Biochemistry: secretin receptor,G protein coupled receptor superfamily,potent regulator of pancreatic secretion
UniProtKB/Swiss-Prot Function: This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Gene Ontology (GO) - Molecular Function for SCTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity --
GO:0015055 secretin receptor activity TAS 7612008
genes like me logo Genes that share ontologies with SCTR: view
genes like me logo Genes that share phenotypes with SCTR: view

Animal Models for SCTR Gene

MGI Knock Outs for SCTR:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SCTR Gene

Localization for SCTR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCTR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCTR Gene COMPARTMENTS Subcellular localization image for SCTR gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
extracellular 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SCTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005881 cytoplasmic microtubule IDA 23264731
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7612008
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SCTR: view

Pathways for SCTR Gene

genes like me logo Genes that share pathways with SCTR: view

Pathways by source for SCTR Gene

Gene Ontology (GO) - Biological Process for SCTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007586 digestion TAS 7612008
GO:0007588 excretion TAS 7612008
genes like me logo Genes that share ontologies with SCTR: view

Compounds for SCTR Gene

(2) Tocris Compounds for SCTR Gene

Compound Action Cas Number
Secretin (human) Gastrointestinal peptide [108153-74-8]
Secretin (rat) Gastrointestinal peptide [121028-49-7]

(1) Drugbank Compounds for SCTR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Secretin
target agonist

(4) IUPHAR Ligand for SCTR Gene

Ligand Type Action Affinity Pubmed IDs
VIP Agonist Agonist 6.3
secretin Agonist Agonist 5.3
[(CH2NH)4,5]secretin Antagonist Antagonist 5.3
[125I](Tyr10)secretin None None

(7) Novoseek inferred chemical compound relationships for SCTR Gene

Compound -log(P) Hits PubMed IDs
l-bpa 76.5 2
adenylate 62.1 7
bicarbonate 50.6 5
cyclic amp 36.5 3
cysteine 21.7 2
genes like me logo Genes that share compounds with SCTR: view

Transcripts for SCTR Gene

Unigene Clusters for SCTR Gene

Secretin receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCTR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: -

Relevant External Links for SCTR Gene

GeneLoc Exon Structure for
SCTR
ECgene alternative splicing isoforms for
SCTR

Expression for SCTR Gene

mRNA expression in normal human tissues for SCTR Gene

mRNA differential expression in normal tissues according to GTEx for SCTR Gene

This gene is overexpressed in Pancreas (39.7) and Kidney - Cortex (4.4).

SOURCE GeneReport for Unigene cluster for SCTR Gene Hs.42091

genes like me logo Genes that share expressions with SCTR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for SCTR Gene

Orthologs for SCTR Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCTR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCTR 35
  • 99.32 (n)
  • 99.09 (a)
SCTR 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCTR 35
  • 87.21 (n)
  • 86.33 (a)
SCTR 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCTR 35
  • 87.38 (n)
  • 86.43 (a)
SCTR 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sctr 35
  • 84.09 (n)
  • 81.86 (a)
Sctr 16
Sctr 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCTR 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sctr 35
  • 84.69 (n)
  • 83.97 (a)
chicken
(Gallus gallus)
Aves SCTR 35
  • 64.8 (n)
  • 63.5 (a)
SCTR 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCTR 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ghrhra 36
  • 40 (a)
OneToMany
sctr 35
  • 57.32 (n)
  • 46.3 (a)
Species with no ortholog for SCTR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCTR Gene

ENSEMBL:
Gene Tree for SCTR (if available)
TreeFam:
Gene Tree for SCTR (if available)

Paralogs for SCTR Gene

Selected SIMAP similar genes for SCTR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCTR: view

Variants for SCTR Gene

Sequence variations from dbSNP and Humsavar for SCTR Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs731777 -- 119,490,276(-) CACTC(A/G)GCCAC intron-variant
rs744927 -- 119,490,335(-) GAGGG(C/T)TTGTG intron-variant
rs893610 -- 119,462,114(+) AAGAG(C/T)GGGCC intron-variant
rs920338 -- 119,495,771(+) GACCA(A/G)GGTTT intron-variant
rs1042656 -- 119,440,094(-) ACCCA(C/T)GGACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SCTR Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV Gain 19166990
nsv874961 CNV Gain 21882294
esv2720634 CNV Deletion 23290073
nsv874962 CNV Gain 21882294
nsv874963 CNV Gain 21882294
nsv874964 CNV Loss 21882294

Relevant External Links for SCTR Gene

HapMap Linkage Disequilibrium report
SCTR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCTR Gene

Disorders for SCTR Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SCTR Gene including...

Search for SCTR Gene in MalaCards »

(8) Novoseek inferred disease relationships for SCTR Gene

Disease -log(P) Hits PubMed IDs
gastrinoma 56.8 6
pancreatic diseases 40.4 1
pancreatic cancer 27.1 1
autistic 15.2 1
cystic fibrosis 12.6 2
genes like me logo Genes that share disorders with SCTR: view

No data available for UniProtKB/Swiss-Prot for SCTR Gene

Publications for SCTR Gene

  1. Molecular cloning and functional characterization of a human secretin receptor. (PMID: 7612008) Chow B.K.-C. (Biochem. Biophys. Res. Commun. 1995) 3 4 23
  2. Molecular cloning and expression of a human secretin receptor. (PMID: 7700244) Patel D.R. … Sreedharan S.P. (Mol. Pharmacol. 1995) 3 4 23
  3. Molecular cloning and functional expression of a human pancreatic secretin receptor. (PMID: 7864894) Jiang S. … Ulrich C.D. (Biochem. Biophys. Res. Commun. 1995) 3 4 23
  4. Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors. (PMID: 7782300) Holtmann M.H. … Miller L.J. (J. Biol. Chem. 1995) 3 23
  5. Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor. (PMID: 9440501) Chow B.K. (Recept Signal Transduct 1997) 3 23

Products for SCTR Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
    • G-Protein-Coupled Receptor Signaling PathwayFinder in human,mouse,rat
    • Neurotransmitter Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SCTR
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SCTR
    • Block miRNA regulation of SCTR using miScript Target Protectors

    Sources for SCTR Gene

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