External Ids for SCTR Gene
Previous GeneCards Identifiers for SCTR Gene
The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]
GeneCards Summary for SCTR Gene
SCTR (Secretin Receptor) is a Protein Coding gene. Diseases associated with SCTR include pancreatic cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include secretin receptor activity. An important paralog of this gene is VIPR2.
UniProtKB/Swiss-Prot for SCTR Gene
This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Secretin receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, GLP-2, GHRH and GIP receptors. Secretin receptors are classically localized to the epithelial cells within the pancreatic and biliary ducts, where they stimulate the release of alkaline bicarbonate-rich fluid to neutralise acidic chyme from the stomach. This protects the duodenal mucosa and provides an optimal intraluminal environment for digestion to take place. Secretin receptors are also found in the CNS, where they are thought to play a role in the regulation of the hypothalamic-pituitary-axis (HPA) axis. The human secretin receptor gene is localized on chromosome 2p14.1.