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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCT Gene

protein-coding   GIFtS: 52
GCID: GC11M000626

Secretin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
secretin1 2
prepro-secretin1 2

External Ids:    HGNC: 106071   Entrez Gene: 63432   Ensembl: ENSG000000700317   OMIM: 1820995   UniProtKB: P096833   

Export aliases for SCT gene to outside databases

Previous GC identifers: GC11P001116 GC11P000936 GC11P000573 GC11M000616 GC11M000441


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCT Gene:
Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is
the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is
stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of
bicarbonate-rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach,
small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the
hormone could have a neuroendocrine function in addition to its role in digestion. (provided by RefSeq, Jul 2008)

GeneCards Summary for SCT Gene: 
SCT (secretin) is a protein-coding gene. Diseases associated with SCT include gastrinoma, and pancreatic diseases, and among its related super-pathways are Signaling by GPCR and Glucagon-type ligand receptors. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot: SECR_HUMAN, P09683
Function: Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits
HCl production by the stomach

Gene Wiki entry for SCT (Secretin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCT gene promoter:
         Sp1   p300   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SCT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

SCT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCT gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000626:  view genomic region     (about GC identifiers)

Start:
626,313 bp from pter      End:
627,173 bp from pter
Size:
861 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SECR_HUMAN, P09683 (See protein sequence)
Recommended Name: Secretin precursor  
Size: 121 amino acids; 13016 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for SCT: NX_P09683

Explore proteomics data for SCT at MOPED 

SCT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SCT Protein Expression

REFSEQ proteins: NP_068739.1  
ENSEMBL proteins: 
 ENSP00000176195  
Reactome Protein details: P09683
Human Recombinant Protein Products for SCT: 
Browse Purified and Recombinant Proteins at EMD Millipore
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Novus Biologicals SCT Proteins
Novus Biologicals SCT Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for SCT
Cloud-Clone Corp. Proteins for SCT 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005576extracellular region TAS--

SCT for ontologies           About GeneDecksing



SCT Antibody Products: 
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Abcam antibodies for SCT
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ThermoFisher Antibodies for SCT
LSBio Antibodies in human, mouse, rat for SCT 

Assay Products for SCT: 
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GenScript Custom Assay Services for SCT
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Cloud-Clone Corp. ELISAs for SCT 
Cloud-Clone Corp. CLIAs for SCT


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands

2 InterPro protein domains:
 IPR015675 Secretin
 IPR000532 Glucagon_GIP_secretin_VIP

Graphical View of Domain Structure for InterPro Entry P09683

ProtoNet protein and cluster: P09683

1 Blocks protein domain: IPB000532 Glucagon/GIP/secretin/VIP

UniProtKB/Swiss-Prot: SECR_HUMAN, P09683
Similarity: Belongs to the glucagon family


SCT for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SECR_HUMAN, P09683
Function: Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits
HCl production by the stomach

     Summary:

During embryonic development, SCT as signaling molecule
affects the following cells: Biliary Epithelial Cells in Intrahepatic Biliary Tree

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity NAS11060443
     
SCT for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for SCT:
 Increased HPV18 LCR reporter a 

     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sct):
 behavior/neurological  homeostasis/metabolism  nervous system 

SCT for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Scttm1.1Bkcc for SCT

   inGenious Targeting Laboratory - Custom generated mouse model solutions for SCT 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCT

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCT 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCT 

miRNA
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Inhib. RNA
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OriGene RNAi products in human, mouse, rat for SCT
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for SCT
Sirion Biotech Customized adenovirus for overexpression of SCT

Clone
Products:
     
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OriGene clones in human, mouse for SCT (see all 7)
OriGene ORF clones in mouse, rat for SCT
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SCT (NM_021920)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCT
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCT
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                     Customized lentivirus expression plasmids for stable overexpression of SCT 

Cell Line
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Search LifeMap BioReagents cell lines for SCT
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCT


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SCT About                                                                                                See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
2Prostacyclin signalling through prostacyclin receptor
Glucagon-type ligand receptors0.58
G alpha (s) signalling events0.31
Class B/2 (Secretin family receptors)0.36
3Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding0.71

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/7        Reactome Pathways for SCT (see all 7)
    GPCR downstream signaling
Glucagon-type ligand receptors
Signal Transduction
Signaling by GPCR
GPCR ligand binding



SCT for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCT

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/73 Interacting proteins for SCT (P096833 ENSP000001761954) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
InteractantInteraction Details
GeneCardExternal ID(s)
SCTRP478723, ENSP000000191034I2D: score=2 STRING: ENSP00000019103
VIPR1P322413, ENSP000003272464I2D: score=2 STRING: ENSP00000327246
MEP1AQ168193, ENSP000002305884I2D: score=1 STRING: ENSP00000230588
MEP1BQ168203, ENSP000002692024I2D: score=1 STRING: ENSP00000269202
UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008542visual learning IEA--
GO:0021542dentate gyrus development IEA--
GO:0030157pancreatic juice secretion NAS11060443
GO:0043524negative regulation of neuron apoptotic process IEA--
GO:0097150neuronal stem cell maintenance IEA--

SCT for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SCT for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SCT (SECR)

10/104 Novoseek inferred chemical compound relationships for SCT gene (see all 104)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
epft 89.5 9 17380405 (2), 17387611 (1), 15481311 (1), 17070454 (1) (see all 6)
pancreozymin 79.5 7 2214619 (1), 2288654 (1), 2124996 (1), 2072227 (1) (see all 6)
btpaba 79.5 12 8093586 (2), 9361096 (2), 10026439 (2), 15754047 (1) (see all 6)
bicarbonate 77.1 110 11559776 (3), 7958697 (3), 8866360 (3), 2396088 (2) (see all 66)
adenylate 72.9 49 12721498 (2), 8171284 (1), 8836153 (1), 10698193 (1) (see all 44)
oxyntomodulin 72.4 12 12296450 (3), 8418694 (2), 11827435 (1), 16249466 (1) (see all 9)
h2dids 68.3 1 8866360 (1)
pacap 38 67 3 12370005 (1), 11334241 (1), 15800375 (1)
helospectin 62.7 1 7703717 (1)
caerulein 61.2 23 8132133 (6), 2201584 (3), 2394497 (2), 14988659 (2) (see all 10)

Search CenterWatch for drugs/clinical trials and news about SCT / SECR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SCT gene: 
NM_021920.2  

Unigene Cluster for SCT:

Secretin
Hs.632324  [show with all ESTs]
Unigene Representative Sequence: NM_021920
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000176195(uc001lqo.1)
miRNA
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Inhib. RNA
Products:
     
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OriGene RNAi products in human, mouse, rat for SCT
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCT
Clone
Products:
     
OriGene clones in human, mouse for SCT (see all 7)
OriGene ORF clones in mouse, rat for SCT
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SCT (NM_021920)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCT
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCT
Sirion Biotech Customized lentivirus for stable overexpression of SCT 
                     Customized lentivirus expression plasmids for stable overexpression of SCT 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for SCT
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCT
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCT
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCT

1 AceView cDNA sequence:

NM_021920 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCT expression in normal human tissues (normalized intensities)      SCT embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SCT Expression
About this image


SCT expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/6 selected tissues (see all 6) fully expand
 
 Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
         small intestine ; glandular cells   
 
 Pancreas (Endocrine System)    fully expand to see all 2 entries
         Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
 
 Gut Tube (Gastrointestinal Tract)
         Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
 
 Heart (Cardiovascular System)
         Atrioventricular Canal Cells Atrioventricular Canal
 
 Testis (Reproductive System)

See SCT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCT

SOURCE GeneReport for Unigene cluster: Hs.632324
    SABiosciences Custom PCR Arrays for SCT
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCT
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCT

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for SCT gene from 1/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sct1 , 5 secretin1, 5 72.83(n)1
62.18(a)1
  7 (86.59 cM)5
202871  NM_011328.21  NP_035458.11 
 1412783385 


ENSEMBL Gene Tree for SCT (if available)
TreeFam Gene Tree for SCT (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/74 SNPs in SCT are shown (see all 74)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs32123201,2
C--627278(-) CAGCTC/G/TGGGGG 1 -- us2k10--------
rs1924389791,2
--627466(+) GTTTGA/GGGGGG 1 -- us2k10--------
rs1128888891,2
C,F--627517(+) GGAGGC/TCCCTG 1 -- us2k12Minor allele frequency- T:0.06NA 122
rs1841148151,2
--627583(+) GGGCCA/GGTGTT 1 -- us2k10--------
rs1885520221,2
C--627642(+) CCATCC/TCCACC 1 -- us2k10--------
rs1505917601,2
--627664(+) GACTTC/TCCCGT 1 -- us2k10--------
rs127895891,2
--627693(+) CAGACA/G/TCTCCC 1 -- us2k10--------
rs1843468261,2
--627897(+) AATCCA/GTTCTC 1 -- us2k10--------
rs285389401,2
C--627943(+) TCTCCT/CGTCCT 1 -- us2k112Minor allele frequency- C:0.02NA WA CSA EA 374
rs1900175761,2
--627968(+) ACAGAC/TGCTCC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SCT (626313 - 627173 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/18 variations for SCT (see all 18):    About this table     
Variant IDTypeSubtypePubMed ID
dgv182e199CNV Deletion23128226
esv2668299CNV Deletion23128226
nsv896545CNV Loss21882294
nsv469923CNV Loss18288195
dgv935n71CNV Loss21882294
nsv896560CNV Loss21882294
nsv467635CNV Loss19166990
nsv896569CNV Loss21882294
dgv922n71CNV Loss21882294
dgv920n71CNV Loss21882294


Human Gene Mutation Database (HGMD): SCT
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing SCT
DNA2.0 Custom Variant and Variant Library Synthesis for SCT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 182099    OMIM disorders: --

20/86 diseases for SCT (see all 86):    About MalaCards
gastrinoma    pancreatic diseases    recurrent acute pancreatitis    pervasive developmental disorder
duodenal gastrinoma    choledochal cyst    mirizzi syndrome    zollinger-ellison syndrome
duodenal ulcer    peptic ulcer    glucagonoma    exocrine pancreatic insufficiency
duodenogastric reflux    steatorrhea    papillary adenocarcinoma    gastritis
obstructive jaundice    angiodysplasia    developmental disabilities    giardiasis


SCT for disorders           About GeneDecksing

10/88 Novoseek inferred disease relationships for SCT gene (see all 88)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
zollinger-ellison syndrome 89.6 29 11328261 (4), 20299818 (2), 1992623 (2), 1624082 (1) (see all 22)
gastrinoma 89 52 17153463 (4), 1455303 (2), 1734697 (2), 8676568 (2) (see all 40)
chronic pancreatitis 87.5 91 9684658 (5), 8026369 (3), 16405545 (3), 10715057 (3) (see all 60)
pancreas divisum 85.4 29 1699712 (3), 12709690 (3), 9850716 (2), 1910496 (2) (see all 16)
pancreatic diseases 83.3 18 10715057 (3), 9629508 (2), 7930780 (1), 10975751 (1) (see all 15)
exocrine pancreatic insufficiency 71.7 3 1636270 (1), 1704633 (1), 17016144 (1)
acute recurrent pancreatitis 70.8 7 10063920 (2), 8071514 (1), 9252847 (1), 18179795 (1) (see all 5)
pancreatic insufficiency 70.7 8 9184712 (1), 11039470 (1), 12229307 (1), 15085023 (1) (see all 7)
pancreas exocrine 69.8 8 8074843 (1), 17238039 (1), 11925783 (1), 16973919 (1) (see all 8)
multiple endocrine neoplasia type 1 69 1 1802924 (1)

Genetic Association Database (GAD): SCT
Human Genome Epidemiology (HuGE) Navigator: SCT (61 documents)

Export disorders for SCT gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SCT gene, integrated from 9 sources (see all 739):
(articles sorted by number of sources associating them with SCT)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA. (PubMed id 11060443)1, 2, 9 Whitmore T.E.... Lok S. (2000)
  2. Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (2010)
  3. Secretin: structure of the precursor and tissue distribution of the mRNA. (PubMed id 2315322)1, 3 Kopin A.S....Leiter A.B. (1990)
  4. Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors. (PubMed id 7782300)1, 9 Holtmann M.H....Miller L.J. (1995)
  5. Secretin inhibits cholangiocarcinoma growth via dysre gulation of the cAMP-dependent signaling mechanisms of secretin receptor. (PubMed id 19904746)1, 9 Onori P....Glaser S.S. (2010)
  6. Human VPAC1 receptor selectivity filter. Identification of a critical domain for restricting secretin binding. (PubMed id 12133828)1, 9 Du K....Laburthe M. (2002)
  7. Secretin self-assembles and interacts spontaneously with phospholipids in vitro. (PubMed id 11814635)1, 9 Gandhi S....Onyuksel H. (2002)
  8. Co-localization of neuroendocrine hormones in the human fetal pancreas. (PubMed id 10576771)1, 9 Portela-Gomes G.M....Grimelius L. (1999)
  9. Peptic ulceration may be a hormonal deficiency disease. (PubMed id 18280672)1, 9 Love J.W. (2008)
  10. Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1. (PubMed id 16888198)1, 9 Lee L.T....Chow B.K. (2006)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6343 HGNC: 10607 AceView: SCT Ensembl:ENSG00000070031 euGenes: HUgn6343
ECgene: SCT H-InvDB: SCT

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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NameDescription
PharmGKB entry for SCT Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Secretin

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