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Aliases for SCT Gene

Aliases for SCT Gene

  • Secretin 2 3
  • Prepro-Secretin 2 3

External Ids for SCT Gene

Previous GeneCards Identifiers for SCT Gene

  • GC11P001116
  • GC11P000936
  • GC11P000573
  • GC11M000616
  • GC11M000441

Summaries for SCT Gene

Entrez Gene Summary for SCT Gene

  • Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of bicarbonate-rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach, small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCT Gene

SCT (Secretin) is a Protein Coding gene. Diseases associated with SCT include spondylocarpotarsal synostosis syndrome and larsen syndrome. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for SCT Gene

  • Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach

Gene Wiki entry for SCT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCT Gene

Genomics for SCT Gene

Regulatory Elements for SCT Gene

Genomic Location for SCT Gene

Start:
626,195 bp from pter
End:
627,898 bp from pter
Size:
1,704 bases
Orientation:
Minus strand

Genomic View for SCT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCT Gene

Proteins for SCT Gene

  • Protein details for SCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09683-SECR_HUMAN
    Recommended name:
    Secretin
    Protein Accession:
    P09683
    Secondary Accessions:

    Protein attributes for SCT Gene

    Size:
    121 amino acids
    Molecular mass:
    13016 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCT Gene

Proteomics data for SCT Gene at MOPED

Post-translational modifications for SCT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SCT Gene

Domains for SCT Gene

Gene Families for SCT Gene

HGNC:

Protein Domains for SCT Gene

Suggested Antigen Peptide Sequences for SCT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09683

UniProtKB/Swiss-Prot:

SECR_HUMAN :
  • P09683
Family:
  • Belongs to the glucagon family.
genes like me logo Genes that share domains with SCT: view

Function for SCT Gene

Molecular function for SCT Gene

UniProtKB/Swiss-Prot Function: Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach

LifeMap Function Summary for SCT Gene

It affects the following cells:

Gene Ontology (GO) - Molecular Function for SCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity NAS 11060443
genes like me logo Genes that share ontologies with SCT: view

Phenotypes for SCT Gene

genes like me logo Genes that share phenotypes with SCT: view

Animal Models for SCT Gene

MGI Knock Outs for SCT:
  • Sct tm1.1Bkcc

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SCT Gene

Localization for SCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCT Gene COMPARTMENTS Subcellular localization image for SCT gene
Compartment Confidence
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with SCT: view

Pathways for SCT Gene

genes like me logo Genes that share pathways with SCT: view

Gene Ontology (GO) - Biological Process for SCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008542 visual learning IEA --
GO:0021542 dentate gyrus development IEA --
GO:0030157 pancreatic juice secretion NAS 11060443
GO:0043524 negative regulation of neuron apoptotic process IEA --
GO:0097150 neuronal stem cell maintenance IEA --
genes like me logo Genes that share ontologies with SCT: view

Compounds for SCT Gene

(104) Novoseek inferred chemical compound relationships for SCT Gene

Compound -log(P) Hits PubMed IDs
epft 89.5 7
pancreozymin 79.5 6
btpaba 79.5 9
bicarbonate 77.1 86
adenylate 72.9 45
genes like me logo Genes that share compounds with SCT: view

Transcripts for SCT Gene

mRNA/cDNA for SCT Gene

(0) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCT Gene

Secretin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCT Gene

No ASD Table

Relevant External Links for SCT Gene

GeneLoc Exon Structure for
SCT
ECgene alternative splicing isoforms for
SCT

Expression for SCT Gene

mRNA expression in normal human tissues for SCT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCT Gene

This gene is overexpressed in Muscle - Skeletal (8.4), Spleen (5.1), and Testis (4.7).

SOURCE GeneReport for Unigene cluster for SCT Gene Hs.632324

genes like me logo Genes that share expressions with SCT: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for SCT Gene

Orthologs for SCT Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCT 35
  • 98.62 (n)
  • 98.35 (a)
SCT 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCT 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sct 16
Sct 36
  • 56 (a)
OneToOne
Species with no ortholog for SCT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCT Gene

ENSEMBL:
Gene Tree for SCT (if available)
TreeFam:
Gene Tree for SCT (if available)

Paralogs for SCT Gene

No data available for Paralogs for SCT Gene

Variants for SCT Gene

Sequence variations from dbSNP and Humsavar for SCT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3212320 -- 627,278(-) CAGCT(C/G/T)GGGGG upstream-variant-2KB, intron-variant
rs3218566 -- 627,216(-) CGGGC(A/G)CCGCC upstream-variant-2KB, intron-variant
rs7102212 -- 628,983(-) AGAAA(A/G)AAAGA upstream-variant-2KB
rs7929088 -- 628,108(-) agggg(A/G)ggggg upstream-variant-2KB
rs11246218 -- 628,996(+) TTCTT(C/T)CTTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SCT Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
nsv896544 CNV Loss 21882294
nsv896545 CNV Loss 21882294
dgv935n71 CNV Loss 21882294
dgv936n71 CNV Loss 21882294
nsv467635 CNV Loss 19166990
nsv896560 CNV Loss 21882294
dgv940n71 CNV Loss 21882294
dgv941n71 CNV Loss 21882294
nsv896569 CNV Loss 21882294
nsv896570 CNV Loss 21882294
dgv942n71 CNV Loss 21882294
esv2668299 CNV Deletion 23128226

Relevant External Links for SCT Gene

HapMap Linkage Disequilibrium report
SCT
Human Gene Mutation Database (HGMD)
SCT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCT Gene

Disorders for SCT Gene

(88) Novoseek inferred disease relationships for SCT Gene

Disease -log(P) Hits PubMed IDs
zollinger-ellison syndrome 89.6 27
gastrinoma 89 49
chronic pancreatitis 87.5 85
pancreas divisum 85.4 27
pancreatic diseases 83.3 18

Relevant External Links for SCT

Genetic Association Database (GAD)
SCT
Human Genome Epidemiology (HuGE) Navigator
SCT
genes like me logo Genes that share disorders with SCT: view

No data available for UniProtKB/Swiss-Prot for SCT Gene

Publications for SCT Gene

  1. Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA. (PMID: 11060443) Whitmore T.E. … Lok S. (Cytogenet. Cell Genet. 2000) 3 4 23
  2. Secretin, glucagon, gastric inhibitory polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus- pituitary-adrenal axis. (PMID: 10764961) Nussdorfer G.G. … Malendowicz L.K. (Peptides 2000) 3 23
  3. Secretin self-assembles and interacts spontaneously with phospholipids in vitro. (PMID: 11814635) Gandhi S. … Onyuksel H. (Peptides 2002) 3 23
  4. Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors. (PMID: 7782300) Holtmann M.H. … Miller L.J. (J. Biol. Chem. 1995) 3 23
  5. The human secretin gene: fine structure in 11p15.5 and sequence variation in patients with autism. (PMID: 12160732) Yamagata T. … Nelson D.L. (Genomics 2002) 3 23

Products for SCT Gene

Sources for SCT Gene

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