Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SCRT2 Gene

Aliases for SCRT2 Gene

  • Scratch Family Transcriptional Repressor 2 2 3 5
  • Scratch (Drosophila Homolog) 2, Zinc Finger Protein 2
  • Scratch Homolog 2, Zinc Finger Protein (Drosophila) 2
  • Scratch Homolog 2, Zinc Finger Protein 3
  • Scratch Homolog 2 Zinc Finger Protein 4
  • Transcriptional Repressor Scratch 2 3
  • Scratch Family Zinc Finger 2 3
  • Scratch 2 Protein 3
  • ZNF898B 3

External Ids for SCRT2 Gene

Previous GeneCards Identifiers for SCRT2 Gene

  • GC20M000632
  • GC20M000592
  • GC20M000639
  • GC20M000576
  • GC20M000591
  • GC20M000642
  • GC20M000593

Summaries for SCRT2 Gene

GeneCards Summary for SCRT2 Gene

SCRT2 (Scratch Family Transcriptional Repressor 2) is a Protein Coding gene. GO annotations related to this gene include transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is SCRT1.

UniProtKB/Swiss-Prot for SCRT2 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRT2 Gene

Genomics for SCRT2 Gene

Regulatory Elements for SCRT2 Gene

Enhancers for SCRT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F000707 0.3 FANTOM5 24.3 -31.5 -31533 0.2 SCRT2 SLC52A3 ANGPT4 TMEM74B PIR59185 GC20P000743
GH20F000727 0.8 Ensembl ENCODE 12.6 -52.3 -52277 1.3 ARID4B ZNF48 GLIS2 CBX5 ZNF143 ZNF263 SP5 MIER2 REST PPARG SCRT2 SRXN1 SLC52A3 CSNK2A1 ANGPT4 SOX12 GC20P000743 PIR59185
GH20F000699 0.6 ENCODE 12.4 -23.8 -23843 0.1 BCOR SMARCA5 ZMYM3 REST NR2F2 YY1 ZFHX2 SMARCA4 ATF3 ADNP SCRT2 SRXN1 SLC52A3 ANGPT4 PIR59185
GH20F000709 0.5 Ensembl 12.3 -34.1 -34122 1.5 ZNF263 ZNF146 NFIA HLF ZMYM3 ZBTB8A ZFHX2 ZBTB33 ZBTB26 EZH2 SCRT2 SRXN1 PIR59185 GC20P000743
GH20F000584 0.2 Ensembl 12.1 +91.7 91678 0.2 USF1 SUZ12 MAX CEBPG ZFHX2 NFYB ZNF143 NFE2 MAFK EGR2 TCF15 SRXN1 CSNK2A1 SCRT2 ACTG1P3 GC20M000594
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SCRT2 on UCSC Golden Path with GeneCards custom track

Promoters for SCRT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001834683 479 201 ARID4B SIN3A ZNF48 ZNF143 MXD4 MIER2 REST PPARG KAT8 ATF4

Genomic Location for SCRT2 Gene

Chromosome:
20
Start:
661,596 bp from pter
End:
676,179 bp from pter
Size:
14,584 bases
Orientation:
Minus strand

Genomic View for SCRT2 Gene

Genes around SCRT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRT2 Gene

Proteins for SCRT2 Gene

  • Protein details for SCRT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ03-SCRT2_HUMAN
    Recommended name:
    Transcriptional repressor scratch 2
    Protein Accession:
    Q9NQ03

    Protein attributes for SCRT2 Gene

    Size:
    307 amino acids
    Molecular mass:
    32584 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCRT2 Gene

Post-translational modifications for SCRT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCRT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCRT2 Gene

Domains & Families for SCRT2 Gene

Protein Domains for SCRT2 Gene

Suggested Antigen Peptide Sequences for SCRT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQ03

UniProtKB/Swiss-Prot:

SCRT2_HUMAN :
  • Belongs to the snail C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Family:
  • Belongs to the snail C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SCRT2: view

Function for SCRT2 Gene

Molecular function for SCRT2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for SCRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IC 21252910
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SCRT2: view
genes like me logo Genes that share phenotypes with SCRT2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRT2 Gene

Localization for SCRT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCRT2 Gene COMPARTMENTS Subcellular localization image for SCRT2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SCRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISS --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SCRT2: view

Pathways & Interactions for SCRT2 Gene

SuperPathways for SCRT2 Gene

No Data Available

Interacting Proteins for SCRT2 Gene

Gene Ontology (GO) - Biological Process for SCRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS --
GO:2001222 regulation of neuron migration IEA --
genes like me logo Genes that share ontologies with SCRT2: view

No data available for Pathways by source and SIGNOR curated interactions for SCRT2 Gene

Transcripts for SCRT2 Gene

mRNA/cDNA for SCRT2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(234) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCRT2 Gene

Scratch homolog 2, zinc finger protein (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRT2 Gene

No ASD Table

Relevant External Links for SCRT2 Gene

GeneLoc Exon Structure for
SCRT2
ECgene alternative splicing isoforms for
SCRT2

Expression for SCRT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCRT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCRT2 Gene

This gene is overexpressed in Brain - Cerebellum (x13.1), Brain - Cerebellar Hemisphere (x10.6), Brain - Frontal Cortex (BA9) (x7.0), and Brain - Cortex (x6.5).

Protein differential expression in normal tissues from HIPED for SCRT2 Gene

This gene is overexpressed in Bone (55.7) and Pancreatic juice (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCRT2 Gene



Protein tissue co-expression partners for SCRT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCRT2 Gene:

SCRT2

SOURCE GeneReport for Unigene cluster for SCRT2 Gene:

Hs.355284
genes like me logo Genes that share expression patterns with SCRT2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SCRT2 Gene

Orthologs for SCRT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCRT2 34
  • 92.66 (n)
rat
(Rattus norvegicus)
Mammalia Scrt2 34
  • 90.74 (n)
mouse
(Mus musculus)
Mammalia Scrt2 34 16 35
  • 90.05 (n)
oppossum
(Monodelphis domestica)
Mammalia SCRT2 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCRT2 34 35
  • 77.27 (n)
lizard
(Anolis carolinensis)
Reptilia SCRT2 35
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii scrt2 34 35
  • 65.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12605 36 35
  • 78 (a)
scrt 36 35
  • 68 (a)
CG17181 36
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea K02D7.2 36
  • 56 (a)
ces-1 35
  • 39 (a)
ManyToMany
Species where no ortholog for SCRT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SCRT2 Gene

ENSEMBL:
Gene Tree for SCRT2 (if available)
TreeFam:
Gene Tree for SCRT2 (if available)

Paralogs for SCRT2 Gene

Paralogs for SCRT2 Gene

genes like me logo Genes that share paralogs with SCRT2: view

Variants for SCRT2 Gene

Sequence variations from dbSNP and Humsavar for SCRT2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs112098553 -- 668,173(+) GTTAC(C/T)GGTAG intron-variant
rs112473676 -- 667,181(+) GTCAG(A/G)CACTC intron-variant
rs112858215 -- 663,558(+) ACGAG(A/C)GGGTC intron-variant, utr-variant-3-prime
rs112894948 -- 663,534(+) TTCCG(A/G)GCCGG intron-variant, utr-variant-3-prime
rs113160648 -- 677,046(+) CCAGG(A/C)TCTCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SCRT2 Gene

Variant ID Type Subtype PubMed ID
esv3644952 CNV gain 21293372
nsv1067424 CNV gain 25217958
nsv1160671 CNV duplication 26073780
nsv952967 CNV deletion 24416366

Variation tolerance for SCRT2 Gene

Gene Damage Index Score: 1.44; 28.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCRT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCRT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRT2 Gene

Disorders for SCRT2 Gene

Relevant External Links for SCRT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCRT2

No disorders were found for SCRT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCRT2 Gene

Publications for SCRT2 Gene

  1. Mammalian scratch: a neural-specific snail family transcriptional repressor. (PMID: 11274425) Nakakura E.K. … Ball D.W. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 64
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  3. Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism. (PMID: 23434913) Itoh Y. … Gotoh Y. (Nat. Neurosci. 2013) 3 64
  4. Repression of Puma by scratch2 is required for neuronal survival during embryonic development. (PMID: 21252910) RodrA-guez-Aznar E. … Nieto M.A. (Cell Death Differ. 2011) 3 64

Products for SCRT2 Gene

Sources for SCRT2 Gene

Content
Loading form....