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Aliases for SCRT2 Gene

Aliases for SCRT2 Gene

  • Scratch Family Zinc Finger 2 2 3
  • Scratch Homolog 2 Zinc Finger Protein 3 4
  • Scratch (Drosophila Homolog) 2, Zinc Finger Protein 2
  • Scratch Homolog 2, Zinc Finger Protein (Drosophila) 2
  • Scratch Homolog 2, Zinc Finger Protein 3
  • Transcriptional Repressor Scratch 2 3
  • Scratch 2 Protein 3
  • ZNF898B 3

External Ids for SCRT2 Gene

Summaries for SCRT2 Gene

GeneCards Summary for SCRT2 Gene

SCRT2 (Scratch Family Zinc Finger 2) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription. An important paralog of this gene is SNAI2.

UniProtKB/Swiss-Prot for SCRT2 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRT2 Gene

Genomics for SCRT2 Gene

Genomic Location for SCRT2 Gene

Start:
661,596 bp from pter
End:
676,179 bp from pter
Size:
14,584 bases
Orientation:
Minus strand

Genomic View for SCRT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCRT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRT2 Gene

Regulatory Elements for SCRT2 Gene

Proteins for SCRT2 Gene

  • Protein details for SCRT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ03-SCRT2_HUMAN
    Recommended name:
    Transcriptional repressor scratch 2
    Protein Accession:
    Q9NQ03
    Secondary Accessions:

    Protein attributes for SCRT2 Gene

    Size:
    307 amino acids
    Molecular mass:
    32584 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCRT2 Gene

Proteomics data for SCRT2 Gene at MOPED

Post-translational modifications for SCRT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCRT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCRT2 Gene

Domains for SCRT2 Gene

Gene Families for SCRT2 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for SCRT2 Gene

UniProtKB/Swiss-Prot:

SCRT2_HUMAN
Family:
  • Belongs to the snail C2H2-type zinc-finger protein family.:
    • Q9NQ03
Similarity:
  • Contains 5 C2H2-type zinc fingers.:
    • Q9NQ03
genes like me logo Genes that share domains with SCRT2: view

Function for SCRT2 Gene

Molecular function for SCRT2 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for SCRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IC 21252910
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SCRT2: view

Phenotypes for SCRT2 Gene

GenomeRNAi human phenotypes for SCRT2:
genes like me logo Genes that share phenotypes with SCRT2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SCRT2 Gene

Localization for SCRT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCRT2 Gene COMPARTMENTS Subcellular localization image for SCRT2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for SCRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISS --
GO:0005634 nucleus --
genes like me logo Genes that share ontologies with SCRT2: view

Pathways for SCRT2 Gene

SuperPathways for SCRT2 Gene

No Data Available

Interacting Proteins for SCRT2 Gene

Gene Ontology (GO) - Biological Process for SCRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS --
GO:2001222 regulation of neuron migration IEA --
genes like me logo Genes that share ontologies with SCRT2: view

No data available for Pathways by source for SCRT2 Gene

Transcripts for SCRT2 Gene

mRNA/cDNA for SCRT2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(234) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCRT2 Gene

Scratch homolog 2, zinc finger protein (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCRT2 Gene

No ASD Table

Relevant External Links for SCRT2 Gene

GeneLoc Exon Structure for
SCRT2
ECgene alternative splicing isoforms for
SCRT2

Expression for SCRT2 Gene

mRNA expression in normal human tissues for SCRT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCRT2 Gene

This gene is overexpressed in Brain - Cerebellum (13.1), Brain - Cerebellar Hemisphere (10.6), Brain - Frontal Cortex (BA9) (7.0), and Brain - Cortex (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCRT2 Gene

SOURCE GeneReport for Unigene cluster for SCRT2 Gene Hs.355284

genes like me logo Genes that share expressions with SCRT2: view

Orthologs for SCRT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCRT2 36
  • 92.66 (n)
  • 92.45 (a)
mouse
(Mus musculus)
Mammalia Scrt2 36
  • 90.05 (n)
  • 90.28 (a)
Scrt2 16
Scrt2 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCRT2 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scrt2 36
  • 90.74 (n)
  • 92.36 (a)
chicken
(Gallus gallus)
Aves SCRT2 36
  • 77.27 (n)
  • 74.71 (a)
SCRT2 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCRT2 37
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii scrt2 36
  • 65.48 (n)
  • 60.36 (a)
scrt2 37
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12605 37
  • 23 (a)
ManyToMany
scrt 37
  • 24 (a)
ManyToMany
CG12605 38
  • 78 (a)
scrt 38
  • 68 (a)
CG17181 38
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea ces-1 37
  • 39 (a)
ManyToMany
K02D7.2 38
  • 56 (a)
Species with no ortholog for SCRT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SCRT2 Gene

ENSEMBL:
Gene Tree for SCRT2 (if available)
TreeFam:
Gene Tree for SCRT2 (if available)

Paralogs for SCRT2 Gene

Paralogs for SCRT2 Gene

genes like me logo Genes that share paralogs with SCRT2: view

Variants for SCRT2 Gene

Sequence variations from dbSNP and Humsavar for SCRT2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs714622 -- 672,422(-) CGCGC(A/G)CACAC intron-variant
rs753490 -- 671,453(-) AGCAG(A/G)CCCAT intron-variant
rs753491 -- 671,287(-) ATGCC(C/T)ACGTC intron-variant
rs2010180 -- 672,290(-) CCCCA(A/G)GCCCA intron-variant
rs2010198 -- 672,619(-) GCGGG(A/G)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCRT2 Gene

Variant ID Type Subtype PubMed ID
nsv912573 CNV Loss 21882294
dgv4512n71 CNV Loss 21882294
nsv912580 CNV Gain 21882294

Relevant External Links for SCRT2 Gene

HapMap Linkage Disequilibrium report
SCRT2

Disorders for SCRT2 Gene

No disorders were found for SCRT2 Gene.

No data available for UniProtKB/Swiss-Prot for SCRT2 Gene

Publications for SCRT2 Gene

  1. Mammalian scratch: a neural-specific snail family transcriptional repressor. (PMID: 11274425) Nakakura E.K. … Ball D.W. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Repression of Puma by scratch2 is required for neuronal survival during embryonic development. (PMID: 21252910) RodrA-guez-Aznar E. … Nieto M.A. (Cell Death Differ. 2011) 3

Products for SCRT2 Gene

Sources for SCRT2 Gene

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