Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SCRT2 Gene

Aliases for SCRT2 Gene

  • Scratch Family Zinc Finger 2 2 3 5
  • Scratch Homolog 2 Zinc Finger Protein 3 4
  • Scratch (Drosophila Homolog) 2, Zinc Finger Protein 2
  • Scratch Homolog 2, Zinc Finger Protein (Drosophila) 2
  • Scratch Homolog 2, Zinc Finger Protein 3
  • Scratch 2 Protein 3
  • ZNF898B 3

External Ids for SCRT2 Gene

Previous GeneCards Identifiers for SCRT2 Gene

  • GC20M000632
  • GC20M000592
  • GC20M000639
  • GC20M000576
  • GC20M000591
  • GC20M000642
  • GC20M000593

Summaries for SCRT2 Gene

GeneCards Summary for SCRT2 Gene

SCRT2 (Scratch Family Zinc Finger 2) is a Protein Coding gene. GO annotations related to this gene include transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is SNAI2.

UniProtKB/Swiss-Prot for SCRT2 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRT2 Gene

Genomics for SCRT2 Gene

Regulatory Elements for SCRT2 Gene

Enhancers for SCRT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCRT2 on UCSC Golden Path with GeneCards custom track

Promoters for SCRT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCRT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCRT2 Gene

661,596 bp from pter
676,179 bp from pter
14,584 bases
Minus strand

Genomic View for SCRT2 Gene

Genes around SCRT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRT2 Gene

Proteins for SCRT2 Gene

  • Protein details for SCRT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcriptional repressor scratch 2
    Protein Accession:

    Protein attributes for SCRT2 Gene

    307 amino acids
    Molecular mass:
    32584 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCRT2 Gene

Proteomics data for SCRT2 Gene at MOPED

Post-translational modifications for SCRT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCRT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCRT2 Gene

Domains & Families for SCRT2 Gene

Protein Domains for SCRT2 Gene

Suggested Antigen Peptide Sequences for SCRT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the snail C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
  • Belongs to the snail C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SCRT2: view

Function for SCRT2 Gene

Molecular function for SCRT2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with SCRT2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRT2 Gene

Localization for SCRT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRT2 Gene

Subcellular locations from

Jensen Localization Image for SCRT2 Gene COMPARTMENTS Subcellular localization image for SCRT2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for SCRT2 Gene

Pathways & Interactions for SCRT2 Gene

SuperPathways for SCRT2 Gene

No Data Available

Interacting Proteins for SCRT2 Gene

Gene Ontology (GO) - Biological Process for SCRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS --
genes like me logo Genes that share ontologies with SCRT2: view

No data available for Pathways by source and SIGNOR curated interactions for SCRT2 Gene

Drugs & Compounds for SCRT2 Gene

No Compound Related Data Available

Transcripts for SCRT2 Gene

mRNA/cDNA for SCRT2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(234) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCRT2 Gene

Scratch homolog 2, zinc finger protein (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCRT2 Gene

No ASD Table

Relevant External Links for SCRT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCRT2 Gene

mRNA expression in normal human tissues for SCRT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCRT2 Gene

This gene is overexpressed in Brain - Cerebellum (x13.1), Brain - Cerebellar Hemisphere (x10.6), Brain - Frontal Cortex (BA9) (x7.0), and Brain - Cortex (x6.5).

Protein differential expression in normal tissues from HIPED for SCRT2 Gene

This gene is overexpressed in Bone (55.7) and Pancreatic juice (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCRT2 Gene

SOURCE GeneReport for Unigene cluster for SCRT2 Gene Hs.355284

genes like me logo Genes that share expression patterns with SCRT2: view

Protein tissue co-expression partners for SCRT2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SCRT2 Gene

Orthologs for SCRT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCRT2 35
  • 92.66 (n)
  • 92.45 (a)
(Mus musculus)
Mammalia Scrt2 35
  • 90.05 (n)
  • 90.28 (a)
Scrt2 16
Scrt2 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Scrt2 35
  • 90.74 (n)
  • 92.36 (a)
(Monodelphis domestica)
Mammalia SCRT2 36
  • 78 (a)
(Gallus gallus)
Aves SCRT2 35
  • 77.27 (n)
  • 74.71 (a)
SCRT2 36
  • 76 (a)
(Anolis carolinensis)
Reptilia SCRT2 36
  • 77 (a)
(Danio rerio)
Actinopterygii scrt2 35
  • 65.48 (n)
  • 60.36 (a)
scrt2 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12605 37
  • 78 (a)
CG17181 37
  • 65 (a)
scrt 37
  • 68 (a)
CG12605 36
  • 23 (a)
scrt 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea K02D7.2 37
  • 56 (a)
ces-1 36
  • 39 (a)
Species with no ortholog for SCRT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SCRT2 Gene

Gene Tree for SCRT2 (if available)
Gene Tree for SCRT2 (if available)

Paralogs for SCRT2 Gene

Paralogs for SCRT2 Gene

genes like me logo Genes that share paralogs with SCRT2: view

Variants for SCRT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SCRT2 Gene

Variant ID Type Subtype PubMed ID
nsv912573 CNV Loss 21882294
dgv4512n71 CNV Loss 21882294
nsv912580 CNV Gain 21882294

Variation tolerance for SCRT2 Gene

Gene Damage Index Score: 1.44; 28.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCRT2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SCRT2 Gene

Disorders for SCRT2 Gene

Relevant External Links for SCRT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCRT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCRT2 Gene

Publications for SCRT2 Gene

  1. Mammalian scratch: a neural-specific snail family transcriptional repressor. (PMID: 11274425) Nakakura E.K. … Ball D.W. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 67
  2. Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism. (PMID: 23434913) Itoh Y. … Gotoh Y. (Nat. Neurosci. 2013) 3
  3. Repression of Puma by scratch2 is required for neuronal survival during embryonic development. (PMID: 21252910) RodrA-guez-Aznar E. … Nieto M.A. (Cell Death Differ. 2011) 3
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3

Products for SCRT2 Gene

Sources for SCRT2 Gene