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Aliases for SCRT1 Gene

Aliases for SCRT1 Gene

  • Scratch Family Transcriptional Repressor 1 2 3 5
  • SCRT 3 4
  • Scratch (Drosophila Homolog) 1, Zinc Finger Protein 2
  • Scratch Homolog 1, Zinc Finger Protein (Drosophila) 2
  • Scratch Homolog 1, Zinc Finger Protein 3
  • Scratch Homolog 1 Zinc Finger Protein 4
  • Transcriptional Repressor Scratch 1 3
  • Scratch Family Zinc Finger 1 3
  • Scratch 1 4
  • ZNF898 3
  • HScrt 4

External Ids for SCRT1 Gene

Previous GeneCards Identifiers for SCRT1 Gene

  • GC08U990134
  • GC08M145160
  • GC08M145560
  • GC08M145526
  • GC08M140668
  • GC08M145554

Summaries for SCRT1 Gene

Entrez Gene Summary for SCRT1 Gene

  • This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. [provided by RefSeq, Jul 2013]

GeneCards Summary for SCRT1 Gene

SCRT1 (Scratch Family Transcriptional Repressor 1) is a Protein Coding gene. Diseases associated with SCRT1 include Pineal Region Meningioma and Rectal Neoplasm. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SCRT2.

UniProtKB/Swiss-Prot for SCRT1 Gene

  • Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRT1 Gene

Genomics for SCRT1 Gene

Regulatory Elements for SCRT1 Gene

Enhancers for SCRT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SCRT1 on UCSC Golden Path with GeneCards custom track

Promoters for SCRT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SCRT1 Gene

Chromosome:
8
Start:
144,330,565 bp from pter
End:
144,336,281 bp from pter
Size:
5,717 bases
Orientation:
Minus strand

Genomic View for SCRT1 Gene

Genes around SCRT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRT1 Gene

Proteins for SCRT1 Gene

  • Protein details for SCRT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWW7-SCRT1_HUMAN
    Recommended name:
    Transcriptional repressor scratch 1
    Protein Accession:
    Q9BWW7
    Secondary Accessions:
    • A8MX66
    • Q96C52

    Protein attributes for SCRT1 Gene

    Size:
    348 amino acids
    Molecular mass:
    35570 Da
    Quaternary structure:
    • Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains).

neXtProt entry for SCRT1 Gene

Post-translational modifications for SCRT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCRT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCRT1 Gene

Domains & Families for SCRT1 Gene

Protein Domains for SCRT1 Gene

Suggested Antigen Peptide Sequences for SCRT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BWW7

UniProtKB/Swiss-Prot:

SCRT1_HUMAN :
  • The N-terminal non zinc-finger region mediates the repressor activity.
  • Belongs to the snail C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • The N-terminal non zinc-finger region mediates the repressor activity.
Family:
  • Belongs to the snail C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SCRT1: view

Function for SCRT1 Gene

Molecular function for SCRT1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation.

Gene Ontology (GO) - Molecular Function for SCRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 11274425
GO:0005515 protein binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SCRT1: view
genes like me logo Genes that share phenotypes with SCRT1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRT1 Gene

Localization for SCRT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCRT1 Gene COMPARTMENTS Subcellular localization image for SCRT1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SCRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SCRT1: view

Pathways & Interactions for SCRT1 Gene

SuperPathways for SCRT1 Gene

No Data Available

Interacting Proteins for SCRT1 Gene

Gene Ontology (GO) - Biological Process for SCRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 11274425
GO:2001222 regulation of neuron migration IEA --
genes like me logo Genes that share ontologies with SCRT1: view

No data available for Pathways by source and SIGNOR curated interactions for SCRT1 Gene

Drugs & Compounds for SCRT1 Gene

No Compound Related Data Available

Transcripts for SCRT1 Gene

mRNA/cDNA for SCRT1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCRT1 Gene

Scratch homolog 1, zinc finger protein (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRT1 Gene

No ASD Table

Relevant External Links for SCRT1 Gene

GeneLoc Exon Structure for
SCRT1
ECgene alternative splicing isoforms for
SCRT1

Expression for SCRT1 Gene

mRNA expression in normal human tissues for SCRT1 Gene

mRNA differential expression in normal tissues according to GTEx for SCRT1 Gene

This gene is overexpressed in Brain - Cerebellum (x8.6), Brain - Cortex (x7.2), Brain - Cerebellar Hemisphere (x7.1), and Brain - Frontal Cortex (BA9) (x5.9).

Protein differential expression in normal tissues from HIPED for SCRT1 Gene

This gene is overexpressed in Brain (25.4), Liver, secretome (22.0), and Bone (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCRT1 Gene



Protein tissue co-expression partners for SCRT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCRT1 Gene:

SCRT1

SOURCE GeneReport for Unigene cluster for SCRT1 Gene:

Hs.31746

mRNA Expression by UniProt/SwissProt for SCRT1 Gene:

Q9BWW7-SCRT1_HUMAN
Tissue specificity: Brain specific.
genes like me logo Genes that share expression patterns with SCRT1: view

Primer Products

Orthologs for SCRT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCRT1 34
  • 89.18 (n)
  • 89.94 (a)
dog
(Canis familiaris)
Mammalia SCRT1 34
  • 90.06 (n)
  • 86.41 (a)
mouse
(Mus musculus)
Mammalia Scrt1 34
  • 89.08 (n)
  • 93.1 (a)
Scrt1 16
chimpanzee
(Pan troglodytes)
Mammalia SCRT1 34
  • 99.25 (n)
  • 99.44 (a)
rat
(Rattus norvegicus)
Mammalia Scrt1 34
  • 88.98 (n)
  • 93.1 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scrt1 34
  • 84.94 (n)
  • 91.85 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.29398 34
scrt1a 34
  • 84.69 (n)
  • 91.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12605 36
  • 78 (a)
CG17181 36
  • 64 (a)
scrt 36
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea K02D7.2 36
  • 54 (a)
Species where no ortholog for SCRT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCRT1 Gene

ENSEMBL:
Gene Tree for SCRT1 (if available)
TreeFam:
Gene Tree for SCRT1 (if available)

Paralogs for SCRT1 Gene

Paralogs for SCRT1 Gene

(15) SIMAP similar genes for SCRT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCRT1: view

Variants for SCRT1 Gene

Sequence variations from dbSNP and Humsavar for SCRT1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7013127 - 144,333,835(+) GGCAG(A/C)GCCGG reference, missense
rs112011550 -- 144,337,914(+) GCTCC(G/T)AGCGC upstream-variant-2KB
rs142851592 -- 144,336,071(+) AGTGG(C/T)GCGCC reference, synonymous-codon
rs142922837 -- 144,331,283(+) GACAT(A/G)GCAGA utr-variant-3-prime
rs112514737 -- 144,331,436(+) AGGAG(C/T)GTAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SCRT1 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
esv2759652 CNV gain+loss 17122850
nsv1126868 CNV deletion 24896259
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612919 CNV gain 21841781
nsv612920 CNV loss 21841781
nsv824804 CNV gain 20364138

Variation tolerance for SCRT1 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCRT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCRT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRT1 Gene

Disorders for SCRT1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SCRT1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pineal region meningioma
  • pineal meningioma
rectal neoplasm
  • neoplasm of rectum
extrahepatic bile duct adenocarcinoma
  • adenocarcinoma of extrahepatic bile duct
optic nerve sheath meningioma
  • meningioma of optic nerve sheath
skull base meningioma
  • meningioma of the skull base
- elite association - COSMIC cancer census association via MalaCards
Search SCRT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCRT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCRT1
genes like me logo Genes that share disorders with SCRT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCRT1 Gene

Publications for SCRT1 Gene

  1. Mammalian scratch: a neural-specific snail family transcriptional repressor. (PMID: 11274425) Nakakura E.K. … Ball D.W. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 65
  4. The SNAIL family member SCRATCH1 is not expressed in human tumors. (PMID: 20043117) Bastid J. … Ansieau S. (Oncol. Rep. 2010) 3 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for SCRT1 Gene

Sources for SCRT1 Gene

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