SCRT1 Gene
protein-coding GIFtS: 47
GCID: GC08M145554
|
|
scratch homolog 1, zinc finger protein (Drosophila)(Previous names: scratch (drosophila homolog) 1, zinc finger protein )
| |
Aliases
for SCRT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Scratch Homolog 1, Zinc Finger Protein (Drosophila)1 2 | | DKFZp547F0721 | | ZNF8981 2 | | Scratch (Drosophila Homolog) 1, Zinc Finger Protein1 | | Scratch 12 3 | | Transcriptional Repressor Scratch 12 | | Scratch Homolog 1 Zinc Finger Protein2 3 | | HScrt1 | | SCRT2 3 | | |
Export aliases for SCRT1 gene to outside databasesPrevious GC identifers: GC08U990134 GC08M145160 GC08M145560 GC08M145526 GC08M140668 |
Summaries
for SCRT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SCRT1:
This gene is a member of the Snail family of C2H2-type zinc finger transcription factors. It codes for aneural-specific transcriptional repressor that binds to E-box motifs. The protein may promote neural differention andmay be involved in cancers with neuroendocrine features. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SCRT1_HUMAN, Q9BWW7Function: Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix(bHLH) transcription factors, critical for neuronal differentiation
|
Genomic Views
for SCRT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_037704.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCRT1 gene promoter:
E2F-3a E2F-4 CREB deltaCREB E2F-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCRT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCRT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3SCRT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M145554: view genomic region
(about GC identifiers)
Start:
|
145,554,454 bp from pter |
End:
|
145,559,943 bp from pter |
Size:
|
5,490 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr8-,PATCHES 145,470,934-145,476,424 |
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Proteins
for SCRT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCRT1_HUMAN, Q9BWW7 (See
protein sequence)Recommended Name: Transcriptional repressor scratch 1 Size: 348 amino acids; 35570 Da
Subunit: Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains)(By similarity)
Subcellular location: Nucleus
Secondary accessions: A8MX66 Q96C52Explore the universe of human proteins at neXtProt for SCRT1: NX_Q9BWW7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BWW7
SCRT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112599.1
ENSEMBL proteins: ENSP00000331692
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
NAS | -- |
SCRT1 for ontologies About GeneDecksing
SCRT1 Antibody Products:
Assay Products for SCRT1: |
Protein
Domains /
Families
for SCRT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCRT1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BWW7ProtoNet protein and cluster: Q9BWW7 UniProtKB/Swiss-Prot: SCRT1_HUMAN, Q9BWW7Domain: The N-terminal non zinc-finger region mediates the repressor activitySimilarity: Belongs to the snail C2H2-type zinc-finger protein familySimilarity: Contains 5 C2H2-type zinc fingers |
Function
for SCRT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SCRT1_HUMAN, Q9BWW7Function: Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix(bHLH) transcription factors, critical for neuronal differentiation
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCRT1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCRT1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SCRT1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for SCRT1:
|
Pathways & Interactions
for SCRT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCRT1
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
TAS | 11274425 |
SCRT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SCRT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SCRT1
Search CenterWatch for drugs/clinical trials and news about SCRT1
|
Transcripts
for SCRT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCRT1 gene: NM_031309.4 Unigene Cluster for SCRT1: Scratch homolog 1, zinc finger protein (Drosophila) Hs.31746 [show with all ESTs]Unigene Representative Sequence: NM_0313091 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000332135(uc003zbw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCRT1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCRT1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SCRT1 (NM_031309) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCRT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCRT1 |
Additional cDNA sequence: AL512683.1 AY014996.1 BC014675.1 BC024967.2 BC093806.1 BC112229.1 2 DOTS entries: DT.91681637 DT.70101489 10 AceView cDNA sequences: BX282754 BM672235 NM_031309 AY014996 BF346626 BC014675 BX441587 BX440119 BX423429 BM700885
GeneLoc Exon Structure
|
Expression
for SCRT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCRT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCCCCTCC
About this image
See SCRT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCRT1
SOURCE GeneReport for Unigene cluster: Hs.31746
UniProtKB/Swiss-Prot: SCRT1_HUMAN, Q9BWW7Tissue specificity: Brain specific
SABiosciences Custom PCR Arrays for SCRT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCRT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCRT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCRT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCRT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCRT1 |
Orthologs
for SCRT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SCRT1 gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Scrt11 , 5 |
scratch homolog 1, zinc finger protein (Drosophila)1, 5 |
88.98(n)1
92.82(a)1 |
|
15 (36.01 cM)5
1707291 NM_130893.31 NP_570963.11
765162035 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.293982 |
Danio rerio scratch-a transcription factor (scrta) more |
76.81(n) |
|
AY147850.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG126053 |
-- |
78(a)
(best of 3) |
|
64A1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
K02D7.23 |
zinc finger protein |
54(a) |
|
IV(311184-312352) -- |
ENSEMBL Gene Tree for SCRT1 (if available)
TreeFam Gene Tree for SCRT1 (if available) |
Paralogs
for SCRT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SCRT1 gene
- SNAI12 SNAI22 SCRT22 SNAI32
15 SIMAP similar genes for SCRT1 using alignment to 1 protein entry: SCRT1_HUMAN:SNAI1 SNAI2 ZNF78L1 SCRT2 SNAI3 ZNF72
ZFP41 ZNF844 ZNF323 ZNF589 ZNF697 ZNF833P
ZNF137P ZNF702P ZNF808
SCRT1 for paralogs About GeneDecksing
|
Genomic Variants
for SCRT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCRT1 (145554454 - 145559943 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SCRT1
3 CNVs: 3752 31457 30306 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCRT1 |
|
Disorders
/ Diseases
for SCRT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCRT1 for disorders About GeneDecksing
OMIM gene information: 605858
OMIM disorders: --
10  diseases for SCRT1: About MalaCardspineal region meningioma olfactory neuroblastoma cerebellar astrocytoma craniopharyngioma
embryonal carcinoma meningioma astrocytoma neuroblastoma
carcinoma neuronitis
4 diseases from the University of Copenhagen DISEASES database for SCRT1:Pineal region meningioma Optic nerve sheath meningioma Skull base meningioma Cerebellar astrocytoma Export disorders for SCRT1 gene to outside databases
|
Publications
for SCRT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCRT1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SCRT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mammalian scratch: a neural-specific snail family transcriptional repressor. (PubMed id 11274425)1, 2, 3 Nakakura E.K.... Ball D.W. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Mammalian Scratch participates in neuronal differentiation in P19 embryonal carcinoma cells. (PubMed id 11687288)1 Nakakura E.K....Ball D.W. (2001)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
|
External Searches for SCRT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCRT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCRT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCRT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SCRT1 gene:
Search GeneIP for patents involving SCRT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SCRT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SCRT1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCRT1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCRT1 | | | OriGene Protein Over-expression Lysate for SCRT1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SCRT1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCRT1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCRT1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
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| |
 |  |  |  | |
| | | | Search Tocris compounds for SCRT1 |
| |  |  |  |  | | | | |
 |
 |
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 | | | SCRT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCRT1 |
|  |  |  | | | | ThermoFisher Antibodies for SCRT1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCRT1 |
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