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Aliases for SCRN3 Gene

Aliases for SCRN3 Gene

  • Secernin 3 2 3 5
  • SES3 3

External Ids for SCRN3 Gene

Previous GeneCards Identifiers for SCRN3 Gene

  • GC02P175464
  • GC02P175085
  • GC02P174968
  • GC02P175260
  • GC02P167140

Summaries for SCRN3 Gene

GeneCards Summary for SCRN3 Gene

SCRN3 (Secernin 3) is a Protein Coding gene. GO annotations related to this gene include dipeptidase activity. An important paralog of this gene is SCRN2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRN3 Gene

Genomics for SCRN3 Gene

Regulatory Elements for SCRN3 Gene

Genomic Location for SCRN3 Gene

Chromosome:
2
Start:
174,395,729 bp from pter
End:
174,429,575 bp from pter
Size:
33,847 bases
Orientation:
Plus strand

Genomic View for SCRN3 Gene

Genes around SCRN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRN3 Gene

Proteins for SCRN3 Gene

  • Protein details for SCRN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VDG4-SCRN3_HUMAN
    Recommended name:
    Secernin-3
    Protein Accession:
    Q0VDG4
    Secondary Accessions:
    • B4DI11
    • C9JPC1
    • D3DPE0
    • Q7L1C5
    • Q9H5R5

    Protein attributes for SCRN3 Gene

    Size:
    424 amino acids
    Molecular mass:
    48544 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAY24217.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SCRN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCRN3 Gene

Proteomics data for SCRN3 Gene at MOPED

Post-translational modifications for SCRN3 Gene

  • Ubiquitination at Lys 398
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SCRN3

No data available for DME Specific Peptides for SCRN3 Gene

Domains & Families for SCRN3 Gene

Protein Domains for SCRN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCRN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q0VDG4

UniProtKB/Swiss-Prot:

SCRN3_HUMAN :
  • Belongs to the peptidase C69 family. Secernin subfamily.
Family:
  • Belongs to the peptidase C69 family. Secernin subfamily.
genes like me logo Genes that share domains with SCRN3: view

No data available for Gene Families for SCRN3 Gene

Function for SCRN3 Gene

Phenotypes for SCRN3 Gene

GenomeRNAi human phenotypes for SCRN3:
genes like me logo Genes that share phenotypes with SCRN3: view

Animal Model Products

miRNA for SCRN3 Gene

miRTarBase miRNAs that target SCRN3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRN3 Gene

Localization for SCRN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCRN3 Gene COMPARTMENTS Subcellular localization image for SCRN3 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SCRN3 Gene

Pathways & Interactions for SCRN3 Gene

SuperPathways for SCRN3 Gene

No Data Available

Interacting Proteins for SCRN3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000272732%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000281172%0d%0a
Selected Interacting proteins: ENSP00000272732 for SCRN3 Gene via STRING

Gene Ontology (GO) - Biological Process for SCRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IBA --
genes like me logo Genes that share ontologies with SCRN3: view

No data available for Pathways by source and SIGNOR curated interactions for SCRN3 Gene

Drugs & Compounds for SCRN3 Gene

No Compound Related Data Available

Transcripts for SCRN3 Gene

Unigene Clusters for SCRN3 Gene

Secernin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCRN3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for SCRN3 Gene

GeneLoc Exon Structure for
SCRN3
ECgene alternative splicing isoforms for
SCRN3

Expression for SCRN3 Gene

mRNA expression in normal human tissues for SCRN3 Gene

Protein differential expression in normal tissues from HIPED for SCRN3 Gene

This gene is overexpressed in Oral epithelium (6.7) and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCRN3 Gene



SOURCE GeneReport for Unigene cluster for SCRN3 Gene Hs.470679

genes like me logo Genes that share expression patterns with SCRN3: view

Protein tissue co-expression partners for SCRN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCRN3 Gene

Orthologs for SCRN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCRN3 35
  • 91.41 (n)
  • 89.98 (a)
SCRN3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCRN3 35
  • 92.6 (n)
  • 91.41 (a)
SCRN3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scrn3 35
  • 84.89 (n)
  • 82.25 (a)
Scrn3 16
Scrn3 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCRN3 35
  • 99.69 (n)
  • 99.29 (a)
SCRN3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scrn3 35
  • 86.18 (n)
  • 85.86 (a)
oppossum
(Monodelphis domestica)
Mammalia SCRN3 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCRN3 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCRN3 35
  • 69.83 (n)
  • 73.97 (a)
SCRN3 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCRN3 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scrn3 35
  • 67.49 (n)
  • 66.34 (a)
zebrafish
(Danio rerio)
Actinopterygii scrn3 35
  • 61.11 (n)
  • 63.53 (a)
wufd60b06 35
scrn3 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001959 35
  • 45.08 (n)
  • 37.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10098 35
  • 42.35 (n)
  • 33.24 (a)
CG10098 36
  • 29 (a)
OneToMany
Species with no ortholog for SCRN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCRN3 Gene

ENSEMBL:
Gene Tree for SCRN3 (if available)
TreeFam:
Gene Tree for SCRN3 (if available)

Paralogs for SCRN3 Gene

Paralogs for SCRN3 Gene

(2) SIMAP similar genes for SCRN3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SCRN3: view

Variants for SCRN3 Gene

Sequence variations from dbSNP and Humsavar for SCRN3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6716400 - 174,401,184(+) AAAAG(C/T)ACAAG reference, missense
rs10497410 - 174,398,335(-) GTTAT(C/T)GACTG intron-variant, reference, missense
VAR_069467 -
rs2606 -- 174,429,986(-) CAATC(A/G)AATAT downstream-variant-500B
rs3396 -- 174,398,940(-) TTTCC(G/T)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCRN3 Gene

Variant ID Type Subtype PubMed ID
nsv875421 CNV Loss 21882294
dgv4366n71 CNV Loss 21882294
dgv4367n71 CNV Loss 21882294
nsv526187 CNV Loss 19592680

Variation tolerance for SCRN3 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.98; 87.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCRN3 Gene

HapMap Linkage Disequilibrium report
SCRN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRN3 Gene

Disorders for SCRN3 Gene

Relevant External Links for SCRN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCRN3

No disorders were found for SCRN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCRN3 Gene

Publications for SCRN3 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. (PMID: 12221138) Way G. … O'Sullivan A.J. (Mol. Biol. Cell 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for SCRN3 Gene

Sources for SCRN3 Gene

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