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Aliases for SCRN3 Gene

Aliases for SCRN3 Gene

  • Secernin 3 2 3 5
  • Secernin-3 3
  • SES3 3

External Ids for SCRN3 Gene

Previous GeneCards Identifiers for SCRN3 Gene

  • GC02P175464
  • GC02P175085
  • GC02P174968
  • GC02P175260
  • GC02P167140

Summaries for SCRN3 Gene

GeneCards Summary for SCRN3 Gene

SCRN3 (Secernin 3) is a Protein Coding gene. Diseases associated with SCRN3 include Acrodysostosis. GO annotations related to this gene include dipeptidase activity. An important paralog of this gene is SCRN2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRN3 Gene

Genomics for SCRN3 Gene

Regulatory Elements for SCRN3 Gene

Enhancers for SCRN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F174442 0.6 Ensembl ENCODE 12.1 +47.3 47280 1.0 CTCF MAFG TEAD3 JUND ZNF316 FOS MAFK EMSY SCRN3 GPR155
GH02F174462 0.2 ENCODE 0.2 +67.2 67239 0.2 CTCF ZNF654 CBX3 WRNIP1 TRIM22 REST RAD21 ZNF664 ZGPAT CEBPA GPR155 SCRN3
GH02F174485 0.7 ENCODE 0.1 +91.2 91247 2.8 ZFP64 SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 GLIS2 ELK1 ZNF263 HNRNPA1P39 LOC105373752 ENSG00000229750 WIPF1 GPR155 SCRN3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SCRN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCRN3 Gene

174,395,729 bp from pter
174,429,575 bp from pter
33,847 bases
Plus strand

Genomic View for SCRN3 Gene

Genes around SCRN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRN3 Gene

Proteins for SCRN3 Gene

  • Protein details for SCRN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DI11
    • C9JPC1
    • D3DPE0
    • Q7L1C5
    • Q9H5R5

    Protein attributes for SCRN3 Gene

    424 amino acids
    Molecular mass:
    48544 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAY24217.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SCRN3 Gene


neXtProt entry for SCRN3 Gene

Post-translational modifications for SCRN3 Gene

  • Ubiquitination at Lys 398
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SCRN3 Gene

Domains & Families for SCRN3 Gene

Protein Domains for SCRN3 Gene


Suggested Antigen Peptide Sequences for SCRN3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C69 family. Secernin subfamily.
  • Belongs to the peptidase C69 family. Secernin subfamily.
genes like me logo Genes that share domains with SCRN3: view

No data available for Gene Families for SCRN3 Gene

Function for SCRN3 Gene

Gene Ontology (GO) - Molecular Function for SCRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016805 dipeptidase activity IEA --
genes like me logo Genes that share ontologies with SCRN3: view

Phenotypes for SCRN3 Gene

GenomeRNAi human phenotypes for SCRN3:
genes like me logo Genes that share phenotypes with SCRN3: view

Animal Model Products

miRNA for SCRN3 Gene

miRTarBase miRNAs that target SCRN3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRN3 Gene

Localization for SCRN3 Gene

Subcellular locations from

Jensen Localization Image for SCRN3 Gene COMPARTMENTS Subcellular localization image for SCRN3 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SCRN3 Gene

Pathways & Interactions for SCRN3 Gene

SuperPathways for SCRN3 Gene

No Data Available

Interacting Proteins for SCRN3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000272732 Q0VDG4-SCRN3_HUMAN for SCRN3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SCRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006887 exocytosis IBA --
genes like me logo Genes that share ontologies with SCRN3: view

No data available for Pathways by source and SIGNOR curated interactions for SCRN3 Gene

Transcripts for SCRN3 Gene

Unigene Clusters for SCRN3 Gene

Secernin 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRN3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP3: -

Relevant External Links for SCRN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCRN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCRN3 Gene

Protein differential expression in normal tissues from HIPED for SCRN3 Gene

This gene is overexpressed in Oral epithelium (6.7) and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCRN3 Gene

Protein tissue co-expression partners for SCRN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCRN3 Gene:


SOURCE GeneReport for Unigene cluster for SCRN3 Gene:

genes like me logo Genes that share expression patterns with SCRN3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCRN3 Gene

Orthologs for SCRN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCRN3 34 35
  • 99.69 (n)
(Canis familiaris)
Mammalia SCRN3 34 35
  • 92.6 (n)
(Bos Taurus)
Mammalia SCRN3 34 35
  • 91.41 (n)
(Rattus norvegicus)
Mammalia Scrn3 34
  • 86.18 (n)
(Mus musculus)
Mammalia Scrn3 34 16 35
  • 84.89 (n)
(Monodelphis domestica)
Mammalia SCRN3 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SCRN3 35
  • 71 (a)
(Gallus gallus)
Aves SCRN3 34 35
  • 69.83 (n)
(Anolis carolinensis)
Reptilia SCRN3 35
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scrn3 34
  • 67.49 (n)
(Danio rerio)
Actinopterygii scrn3 34 35
  • 61.11 (n)
wufd60b06 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001959 34
  • 45.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10098 34 35
  • 42.35 (n)
Species where no ortholog for SCRN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCRN3 Gene

Gene Tree for SCRN3 (if available)
Gene Tree for SCRN3 (if available)

Paralogs for SCRN3 Gene

Paralogs for SCRN3 Gene

(2) SIMAP similar genes for SCRN3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SCRN3: view

Variants for SCRN3 Gene

Sequence variations from dbSNP and Humsavar for SCRN3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10197754 -- 174,424,691(+) GTAAA(G/T)TTAGA intron-variant
rs10203361 -- 174,401,562(+) GGAGT(A/G)GGGTT intron-variant
rs1023836 -- 174,418,411(-) TGCAG(A/C)ACAGT intron-variant
rs1023837 -- 174,418,322(-) TATAA(C/T)GTACT intron-variant
rs1045661 -- 174,428,160(+) CCATA(C/G)TAACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SCRN3 Gene

Variant ID Type Subtype PubMed ID
esv3332152 CNV insertion 20981092
esv3893507 CNV loss 25118596
nsv1150413 CNV duplication 26484159
nsv526187 CNV loss 19592680
nsv583667 CNV loss 21841781

Variation tolerance for SCRN3 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.98; 87.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCRN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRN3 Gene

Disorders for SCRN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCRN3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • acrodysplasia
- elite association - COSMIC cancer census association via MalaCards
Search SCRN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCRN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SCRN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCRN3 Gene

Publications for SCRN3 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. (PMID: 12221138) Way G. … O'Sullivan A.J. (Mol. Biol. Cell 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SCRN3 Gene

Sources for SCRN3 Gene

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