SCRN3 Gene
protein-coding GIFtS: 41
GCID: GC02P175260
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|
secernin 3
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Aliases
for SCRN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Secernin 31 2 | | FLJ231421 | | SES32 | | Secernin-31 |
Export aliases for SCRN3 gene to outside databasesPrevious GC identifers: GC02P175464 GC02P175085 GC02P174968 GC02P167140 |
Summaries
for SCRN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SCRN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCRN3 gene promoter:
Elk-1 POU6F1 (c2) LCR-F1 GATA-2 POU2F1 POU2F1a FOXO1a NF-Y CBF(2) FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCRN3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCRN3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31SCRN3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P175260: view genomic region
(about GC identifiers)
Start:
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175,260,457 bp from pter |
End:
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175,294,303 bp from pter |
Size:
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33,847 bases |
Orientation:
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plus strand |
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Proteins
for SCRN3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCRN3_HUMAN, Q0VDG4 (See
protein sequence)Recommended Name: Secernin-3 Size: 424 amino acids; 48544 Da
Sequence caution: Sequence=AAY24217.1; Type=Erroneous gene model prediction;
Secondary accessions: B4DI11 C9JPC1 D3DPE0 Q7L1C5 Q9H5R5Alternative splicing: 2 isoforms: Q0VDG4-1 Q0VDG4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SCRN3: NX_Q0VDG4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q0VDG4
SCRN3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001180457.1 NP_078859.2
ENSEMBL proteins: ENSP00000400421 ENSP00000447307 ENSP00000396884 ENSP00000387142 ENSP00000272732 ENSP00000394024 ENSP00000402086 ENSP00000408376 ENSP00000446727
Human Recombinant Protein Products:
SCRN3 Antibody Products:
Assay Products for SCRN3: |
Protein
Domains /
Families
for SCRN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCRN3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q0VDG4ProtoNet protein and cluster: Q0VDG4 UniProtKB/Swiss-Prot: SCRN3_HUMAN, Q0VDG4Similarity: Belongs to the peptidase C69 family. Secernin subfamily |
Function
for SCRN3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCRN3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCRN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SCRN3 (NM_024583) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCRN3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCRN3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCRN3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016805 | dipeptidase activity |
IEA | -- |
SCRN3 for ontologies About GeneDecksing
|
Pathways & Interactions
for SCRN3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCRN3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SCRN3 (ENSP000002727324) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
SCRN3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SCRN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SCRN3
Search CenterWatch for drugs/clinical trials and news about SCRN3
|
Transcripts
for SCRN3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCRN3 gene (2 alternative transcripts): NM_001193528.1 NM_024583.4 Unigene Cluster for SCRN3: Secernin 3 Hs.470679 [show with all ESTs]Unigene Representative Sequence: NM_02458314 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000437944 ENST00000548868 ENST00000458563 ENST00000490927 ENST00000409673
ENST00000272732(uc002uiq.3 uc010zen.2 uc010zeo.2 uc002uis.3)
ENST00000435964 ENST00000424069 ENST00000488349 ENST00000427038(uc002uir.1)
ENST00000548031 ENST00000548921 ENST00000549848 ENST00000475928
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCRN3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCRN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SCRN3 (NM_024583) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCRN3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCRN3 |
Additional cDNA sequence: AF279776.1 AK026795.1 AK057912.1 AK295357.1 AK296558.1 BC031821.1 BC119684.1 BC119685.1 U61107.1 13 DOTS entries: DT.108966 DT.95166962 DT.97791103 DT.100787344 DT.92429129 DT.100796219 DT.97841406 DT.87046470 DT.95166965 DT.120970649 DT.86850648 DT.92429121 DT.95220249 24/143 AceView cDNA sequences (see all 143): AA009907 CB159462 BF515564 AI123953 BF507702 AA313548 BG400817 AI590381 AA227619 CA947007 BU741964 AA227485 AK026795 AI632845 CR614109 BM725063 AA256840 NM_024583 AA577395 BM464484 AI282042 AL516779 AA693989 AA046342
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SCRN3 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SCRN3
|
Expression
for SCRN3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCRN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SCRN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCRN3
SOURCE GeneReport for Unigene cluster: Hs.470679
SABiosciences Custom PCR Arrays for SCRN3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCRN3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCRN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCRN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCRN3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCRN3 |
Orthologs
for SCRN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SCRN3 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for SCRN3 (if available)
TreeFam Gene Tree for SCRN3 (if available) |
Paralogs
for SCRN3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SCRN3 gene
- SCRN22 SCRN12
2 SIMAP similar genes for SCRN3 using alignment to 7 protein entries: SCRN3_HUMAN (see all proteins):SCRN2 SCRN1
SCRN3 for paralogs About GeneDecksing
|
Genomic Variants
for SCRN3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCRN3 (175260457 - 175294303 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCRN3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCRN3 |
|
Disorders
/ Diseases
for SCRN3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SCRN3 for disorders About MalaCards
SCRN3 for disorders About GeneDecksing
OMIM gene information: 614967
OMIM disorders: --
Export disorders for SCRN3 gene to outside databases
|
Publications
for SCRN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCRN3 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SCRN3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. (PubMed id 12221138)1, 3 Way G....O'Sullivan A.J. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes. (PubMed id 11238933)1 Speek M. (2001)
|
External Searches for SCRN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCRN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCRN3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCRN3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SCRN3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SCRN3 gene:
Search GeneIP for patents involving SCRN3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SCRN3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SCRN3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCRN3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCRN3 | | | OriGene Protein Over-expression Lysate for SCRN3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SCRN3 | | OriGene 3'-UTR Clone for SCRN3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCRN3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCRN3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SCRN3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SCRN3 | | OriGene Custom Protein Services for SCRN3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCRN3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCRN3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCRN3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCRN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCRN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCRN3 |
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| | | | Search Tocris compounds for SCRN3 |
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 | | | SCRN3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCRN3 |
|  |  |  | | | | ThermoFisher Antibody for SCRN3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCRN3 |
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