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Aliases for SCRN3 Gene

Aliases for SCRN3 Gene

  • Secernin 3 2 3
  • SES3 3

External Ids for SCRN3 Gene

Previous GeneCards Identifiers for SCRN3 Gene

  • GC02P175464
  • GC02P175085
  • GC02P174968
  • GC02P175260
  • GC02P167140

Summaries for SCRN3 Gene

GeneCards Summary for SCRN3 Gene

SCRN3 (Secernin 3) is a Protein Coding gene. Diseases associated with SCRN3 include acrodysostosis. GO annotations related to this gene include dipeptidase activity. An important paralog of this gene is SCRN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRN3 Gene

Genomics for SCRN3 Gene

Regulatory Elements for SCRN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCRN3 Gene

174,395,729 bp from pter
174,429,575 bp from pter
33,847 bases
Plus strand

Genomic View for SCRN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCRN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRN3 Gene

Proteins for SCRN3 Gene

  • Protein details for SCRN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DI11
    • C9JPC1
    • D3DPE0
    • Q7L1C5
    • Q9H5R5

    Protein attributes for SCRN3 Gene

    424 amino acids
    Molecular mass:
    48544 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAY24217.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SCRN3 Gene


neXtProt entry for SCRN3 Gene

Proteomics data for SCRN3 Gene at MOPED

Post-translational modifications for SCRN3 Gene

  • Ubiquitination at Lys 398
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SCRN3

No data available for DME Specific Peptides for SCRN3 Gene

Domains & Families for SCRN3 Gene

Protein Domains for SCRN3 Gene


Suggested Antigen Peptide Sequences for SCRN3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C69 family. Secernin subfamily.
  • Belongs to the peptidase C69 family. Secernin subfamily.
genes like me logo Genes that share domains with SCRN3: view

No data available for Gene Families for SCRN3 Gene

Function for SCRN3 Gene

Gene Ontology (GO) - Molecular Function for SCRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016805 dipeptidase activity IEA --
genes like me logo Genes that share ontologies with SCRN3: view

Phenotypes for SCRN3 Gene

GenomeRNAi human phenotypes for SCRN3:
genes like me logo Genes that share phenotypes with SCRN3: view

Animal Model Products

miRNA for SCRN3 Gene

miRTarBase miRNAs that target SCRN3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRN3 Gene

Localization for SCRN3 Gene

Subcellular locations from

Jensen Localization Image for SCRN3 Gene COMPARTMENTS Subcellular localization image for SCRN3 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for SCRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IBA --
genes like me logo Genes that share ontologies with SCRN3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SCRN3 Gene

Pathways & Interactions for SCRN3 Gene

SuperPathways for SCRN3 Gene

No Data Available

Interacting Proteins for SCRN3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000272732 for SCRN3 Gene via STRING

Gene Ontology (GO) - Biological Process for SCRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006887 exocytosis IBA --
genes like me logo Genes that share ontologies with SCRN3: view

No data available for Pathways by source and SIGNOR curated interactions for SCRN3 Gene

Drugs & Compounds for SCRN3 Gene

No Compound Related Data Available

Transcripts for SCRN3 Gene

Unigene Clusters for SCRN3 Gene

Secernin 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCRN3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRN3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP3: -

Relevant External Links for SCRN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCRN3 Gene

mRNA expression in normal human tissues for SCRN3 Gene

Protein differential expression in normal tissues from HIPED for SCRN3 Gene

This gene is overexpressed in Oral epithelium (6.7) and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCRN3 Gene

SOURCE GeneReport for Unigene cluster for SCRN3 Gene Hs.470679

genes like me logo Genes that share expression patterns with SCRN3: view

Protein tissue co-expression partners for SCRN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCRN3 Gene

Orthologs for SCRN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCRN3 35
  • 91.41 (n)
  • 89.98 (a)
SCRN3 36
  • 90 (a)
(Canis familiaris)
Mammalia SCRN3 35
  • 92.6 (n)
  • 91.41 (a)
SCRN3 36
  • 91 (a)
(Mus musculus)
Mammalia Scrn3 35
  • 84.89 (n)
  • 82.25 (a)
Scrn3 16
Scrn3 36
  • 82 (a)
(Pan troglodytes)
Mammalia SCRN3 35
  • 99.69 (n)
  • 99.29 (a)
SCRN3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Scrn3 35
  • 86.18 (n)
  • 85.86 (a)
(Monodelphis domestica)
Mammalia SCRN3 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SCRN3 36
  • 71 (a)
(Gallus gallus)
Aves SCRN3 35
  • 69.83 (n)
  • 73.97 (a)
SCRN3 36
  • 72 (a)
(Anolis carolinensis)
Reptilia SCRN3 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scrn3 35
  • 67.49 (n)
  • 66.34 (a)
(Danio rerio)
Actinopterygii scrn3 35
  • 61.11 (n)
  • 63.53 (a)
wufd60b06 35
scrn3 36
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001959 35
  • 45.08 (n)
  • 37.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10098 35
  • 42.35 (n)
  • 33.24 (a)
CG10098 36
  • 29 (a)
Species with no ortholog for SCRN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCRN3 Gene

Gene Tree for SCRN3 (if available)
Gene Tree for SCRN3 (if available)

Paralogs for SCRN3 Gene

Paralogs for SCRN3 Gene

(2) SIMAP similar genes for SCRN3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SCRN3: view

Variants for SCRN3 Gene

Sequence variations from dbSNP and Humsavar for SCRN3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2606 -- 174,429,986(-) CAATC(A/G)AATAT downstream-variant-500B
rs3396 -- 174,398,940(-) TTTCC(G/T)ATTCT intron-variant
rs11745 -- 174,429,882(-) taaga(A/G)gtcac downstream-variant-500B
rs1023836 -- 174,418,411(-) TGCAG(A/C)ACAGT intron-variant
rs1023837 -- 174,418,322(-) TATAA(C/T)GTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCRN3 Gene

Variant ID Type Subtype PubMed ID
nsv875421 CNV Loss 21882294
dgv4366n71 CNV Loss 21882294
dgv4367n71 CNV Loss 21882294
nsv526187 CNV Loss 19592680

Variation tolerance for SCRN3 Gene

Residual Variation Intolerance Score: 81.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.98; 87.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCRN3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRN3 Gene

Disorders for SCRN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCRN3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • acrodysplasia
- elite association
Search SCRN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCRN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SCRN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCRN3 Gene

Publications for SCRN3 Gene

  1. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. (PMID: 12221138) Way G. … O'Sullivan A.J. (Mol. Biol. Cell 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Exome sequencing identifies PDE4D mutations in acrodysostosis. (PMID: 22464252) Lee H. … Cohn D.H. (Am. J. Hum. Genet. 2012) 67
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for SCRN3 Gene

Sources for SCRN3 Gene

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