Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SCRN2 Gene

Aliases for SCRN2 Gene

  • Secernin 2 2 3
  • Ses2 3

External Ids for SCRN2 Gene

Previous GeneCards Identifiers for SCRN2 Gene

  • GC17M046390
  • GC17M043270
  • GC17M045915
  • GC17M041283

Summaries for SCRN2 Gene

GeneCards Summary for SCRN2 Gene

SCRN2 (Secernin 2) is a Protein Coding gene. GO annotations related to this gene include dipeptidase activity. An important paralog of this gene is SCRN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRN2 Gene

Genomics for SCRN2 Gene

Regulatory Elements for SCRN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCRN2 Gene

Chromosome:
17
Start:
47,837,681 bp from pter
End:
47,841,333 bp from pter
Size:
3,653 bases
Orientation:
Minus strand

Genomic View for SCRN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRN2 Gene

Proteins for SCRN2 Gene

  • Protein details for SCRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FV2-SCRN2_HUMAN
    Recommended name:
    Secernin-2
    Protein Accession:
    Q96FV2
    Secondary Accessions:
    • A8K3N1
    • B7Z8S7
    • E9PBV5
    • Q96AC3
    • Q9BU04

    Protein attributes for SCRN2 Gene

    Size:
    425 amino acids
    Molecular mass:
    46597 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH10408.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SCRN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCRN2 Gene

Proteomics data for SCRN2 Gene at MOPED

Post-translational modifications for SCRN2 Gene

  • Ubiquitination at Lys 215 and Lys 272
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SCRN2 Gene

Domains & Families for SCRN2 Gene

Protein Domains for SCRN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCRN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96FV2

UniProtKB/Swiss-Prot:

SCRN2_HUMAN :
  • Belongs to the peptidase C69 family. Secernin subfamily.
Family:
  • Belongs to the peptidase C69 family. Secernin subfamily.
genes like me logo Genes that share domains with SCRN2: view

No data available for Gene Families for SCRN2 Gene

Function for SCRN2 Gene

Gene Ontology (GO) - Molecular Function for SCRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016805 dipeptidase activity IEA --
genes like me logo Genes that share ontologies with SCRN2: view

Phenotypes for SCRN2 Gene

GenomeRNAi human phenotypes for SCRN2:
genes like me logo Genes that share phenotypes with SCRN2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCRN2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCRN2 Gene

Localization for SCRN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCRN2 Gene COMPARTMENTS Subcellular localization image for SCRN2 gene
Compartment Confidence
extracellular 5
nucleus 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SCRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SCRN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SCRN2 Gene

Pathways & Interactions for SCRN2 Gene

SuperPathways for SCRN2 Gene

No Data Available

Interacting Proteins for SCRN2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000290216%0d%0a9606.ENSP00000267415%0d%0a9606.ENSP00000300086%0d%0a
Selected Interacting proteins: ENSP00000290216 for SCRN2 Gene via STRING

Gene Ontology (GO) - Biological Process for SCRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006887 exocytosis IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SCRN2: view

No data available for Pathways by source and SIGNOR curated interactions for SCRN2 Gene

Drugs & Compounds for SCRN2 Gene

No Compound Related Data Available

Transcripts for SCRN2 Gene

Unigene Clusters for SCRN2 Gene

Secernin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCRN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - - -
SP10: - - - - - -
SP11: - - - -
SP12:
SP13: -

ExUns: 9a · 9b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SCRN2 Gene

GeneLoc Exon Structure for
SCRN2
ECgene alternative splicing isoforms for
SCRN2

Expression for SCRN2 Gene

mRNA expression in normal human tissues for SCRN2 Gene

Protein differential expression in normal tissues from HIPED for SCRN2 Gene

This gene is overexpressed in Nasopharynx (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCRN2 Gene



SOURCE GeneReport for Unigene cluster for SCRN2 Gene Hs.239718

genes like me logo Genes that share expression patterns with SCRN2: view

Protein tissue co-expression partners for SCRN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCRN2 Gene

Orthologs for SCRN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCRN2 35
  • 88.24 (n)
  • 87.29 (a)
SCRN2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCRN2 35
  • 87.45 (n)
  • 89.18 (a)
SCRN2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scrn2 35
  • 84.1 (n)
  • 85.64 (a)
Scrn2 16
Scrn2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCRN2 35
  • 99.45 (n)
  • 98.82 (a)
SCRN2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scrn2 35
  • 83.86 (n)
  • 85.57 (a)
oppossum
(Monodelphis domestica)
Mammalia SCRN2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCRN2 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCRN2 35
  • 71.95 (n)
  • 70.77 (a)
SCRN2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCRN2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scrn2 35
  • 66.86 (n)
  • 71.31 (a)
zebrafish
(Danio rerio)
Actinopterygii scrn2 35
  • 63.45 (n)
  • 63.61 (a)
scrn2 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10098 36
  • 25 (a)
OneToMany
Species with no ortholog for SCRN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCRN2 Gene

ENSEMBL:
Gene Tree for SCRN2 (if available)
TreeFam:
Gene Tree for SCRN2 (if available)

Paralogs for SCRN2 Gene

Paralogs for SCRN2 Gene

(2) SIMAP similar genes for SCRN2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SCRN2: view

Variants for SCRN2 Gene

Sequence variations from dbSNP and Humsavar for SCRN2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1004770 -- 47,839,781(-) GATAC(C/G)ATCAG intron-variant
rs1005655 -- 47,842,099(-) GTAAA(A/G)GCACC upstream-variant-2KB
rs2074191 -- 47,839,359(-) CTGTC(A/G)GGACA intron-variant
rs7350956 -- 47,838,576(+) GCTGC(C/G/T)TGGGA missense, reference, nc-transcript-variant
rs7350974 - 47,838,422(+) CCCCA(C/T)CCCGA reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SCRN2 Gene

Variant ID Type Subtype PubMed ID
nsv908573 CNV Loss 21882294
nsv908574 CNV Loss 21882294
nsv517880 CNV Loss 19592680
nsv518892 CNV Loss 19592680

Variation tolerance for SCRN2 Gene

Residual Variation Intolerance Score: 83.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCRN2 Gene

HapMap Linkage Disequilibrium report
SCRN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRN2 Gene

Disorders for SCRN2 Gene

Relevant External Links for SCRN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCRN2
genes like me logo Genes that share disorders with SCRN2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCRN2 Gene

Publications for SCRN2 Gene

  1. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. (PMID: 12221138) Way G. … O'Sullivan A.J. (Mol. Biol. Cell 2002) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67

Products for SCRN2 Gene

Sources for SCRN2 Gene

Back to Top

Content