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Aliases for SCRN2 Gene

Aliases for SCRN2 Gene

  • Secernin 2 2 3 5
  • Secernin-2 3
  • Ses2 3

External Ids for SCRN2 Gene

Previous GeneCards Identifiers for SCRN2 Gene

  • GC17M046390
  • GC17M043270
  • GC17M045915
  • GC17M041283

Summaries for SCRN2 Gene

GeneCards Summary for SCRN2 Gene

SCRN2 (Secernin 2) is a Protein Coding gene. GO annotations related to this gene include dipeptidase activity. An important paralog of this gene is SCRN3.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRN2 Gene

Genomics for SCRN2 Gene

Regulatory Elements for SCRN2 Gene

Enhancers for SCRN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G047964 1.7 FANTOM5 Ensembl ENCODE dbSUPER 26.3 -125.7 -125697 4.6 MLX ARNT SIN3A ARID4B FEZF1 YY1 ZNF121 SLC30A9 GATA2 FOS SCRN2 CDK5RAP3 PNPO PRR15L SKAP1 SP2-AS1 SP2 MIR152 COPZ2 CBX1
GH17G047944 1.6 Ensembl ENCODE dbSUPER 26.3 -111.7 -111698 17.0 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SCRN2 PRR15L CDK5RAP3 COPZ2 PNPO SP2 CBX1 SNX11 NFE2L1 LOC102724532
GH17G047846 1.4 Ensembl ENCODE dbSUPER 30 -6.3 -6262 2.0 PKNOX1 DMAP1 RAD21 ZBTB7B YY1 THAP11 HMG20B CEBPB GATAD2B ZEB2 SCRN2 LRRC46 ENSG00000264243
GH17G048011 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21.7 -172.1 -172099 4.3 HDGF PKNOX1 ARNT SIN3A ZNF2 ZBTB7B ZNF143 ZNF207 ZNF548 ZNF263 PRR15L SCRN2 COPZ2 CDK5RAP3 SKAP1 MRPL45P2 CBX1 SUMO2P17 MIR152 RPS2P47
GH17G047941 1.4 ENCODE dbSUPER 29.4 -100.5 -100524 2.0 MLX CREB3L1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 SP3 NFYC TBX21 MRPL45P2 ENSG00000264701 SCRN2 ENSG00000230532 RPS2P47 ENSG00000266601 LOC102724532 SP2-AS1 HOXB4 LRRC37A17P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCRN2 on UCSC Golden Path with GeneCards custom track

Promoters for SCRN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095221 333 801 HDGF CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for SCRN2 Gene

Chromosome:
17
Start:
47,837,681 bp from pter
End:
47,841,333 bp from pter
Size:
3,653 bases
Orientation:
Minus strand

Genomic View for SCRN2 Gene

Genes around SCRN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRN2 Gene

Proteins for SCRN2 Gene

  • Protein details for SCRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FV2-SCRN2_HUMAN
    Recommended name:
    Secernin-2
    Protein Accession:
    Q96FV2
    Secondary Accessions:
    • A8K3N1
    • B7Z8S7
    • E9PBV5
    • Q96AC3
    • Q9BU04

    Protein attributes for SCRN2 Gene

    Size:
    425 amino acids
    Molecular mass:
    46597 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH10408.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SCRN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCRN2 Gene

Post-translational modifications for SCRN2 Gene

  • Ubiquitination at isoforms=2215 and isoforms=2272
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SCRN2 Gene

Domains & Families for SCRN2 Gene

Protein Domains for SCRN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCRN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96FV2

UniProtKB/Swiss-Prot:

SCRN2_HUMAN :
  • Belongs to the peptidase C69 family. Secernin subfamily.
Family:
  • Belongs to the peptidase C69 family. Secernin subfamily.
genes like me logo Genes that share domains with SCRN2: view

No data available for Gene Families for SCRN2 Gene

Function for SCRN2 Gene

Gene Ontology (GO) - Molecular Function for SCRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21044950
GO:0016805 dipeptidase activity IEA --
genes like me logo Genes that share ontologies with SCRN2: view
genes like me logo Genes that share phenotypes with SCRN2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCRN2 Gene

Localization for SCRN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCRN2 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SCRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SCRN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SCRN2 Gene

Pathways & Interactions for SCRN2 Gene

SuperPathways for SCRN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006887 exocytosis IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SCRN2: view

No data available for Pathways by source and SIGNOR curated interactions for SCRN2 Gene

Transcripts for SCRN2 Gene

Unigene Clusters for SCRN2 Gene

Secernin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - - -
SP10: - - - - - -
SP11: - - - -
SP12:
SP13: -

ExUns: 9a · 9b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SCRN2 Gene

GeneLoc Exon Structure for
SCRN2
ECgene alternative splicing isoforms for
SCRN2

Expression for SCRN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCRN2 Gene

Protein differential expression in normal tissues from HIPED for SCRN2 Gene

This gene is overexpressed in Nasopharynx (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCRN2 Gene



Protein tissue co-expression partners for SCRN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCRN2 Gene:

SCRN2

SOURCE GeneReport for Unigene cluster for SCRN2 Gene:

Hs.239718

Evidence on tissue expression from TISSUES for SCRN2 Gene

  • Liver(4.2)
  • Lung(4.2)
  • Skin(4.2)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with SCRN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCRN2 Gene

Orthologs for SCRN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCRN2 34 35
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia SCRN2 34 35
  • 88.24 (n)
dog
(Canis familiaris)
Mammalia SCRN2 34 35
  • 87.45 (n)
mouse
(Mus musculus)
Mammalia Scrn2 34 16 35
  • 84.1 (n)
rat
(Rattus norvegicus)
Mammalia Scrn2 34
  • 83.86 (n)
oppossum
(Monodelphis domestica)
Mammalia SCRN2 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCRN2 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCRN2 34 35
  • 71.95 (n)
lizard
(Anolis carolinensis)
Reptilia SCRN2 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scrn2 34
  • 66.86 (n)
zebrafish
(Danio rerio)
Actinopterygii scrn2 34 35
  • 63.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10098 35
  • 25 (a)
OneToMany
Species where no ortholog for SCRN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCRN2 Gene

ENSEMBL:
Gene Tree for SCRN2 (if available)
TreeFam:
Gene Tree for SCRN2 (if available)

Paralogs for SCRN2 Gene

Paralogs for SCRN2 Gene

(2) SIMAP similar genes for SCRN2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SCRN2: view

Variants for SCRN2 Gene

Sequence variations from dbSNP and Humsavar for SCRN2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000443986 -- 47,841,219(+) TTCCT(C/T)CAAGA nc-transcript-variant, utr-variant-5-prime
rs1000475114 -- 47,841,013(+) TCCCC(A/C)GGCTC intron-variant
rs1000612511 -- 47,840,939(+) GACAC(C/T)GCCGT intron-variant
rs1000643593 -- 47,840,586(+) GCCTC(C/T)CAGGT intron-variant
rs1001163366 -- 47,842,728(+) GAGGT(A/T)GGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SCRN2 Gene

Variant ID Type Subtype PubMed ID
dgv947e212 CNV loss 25503493
nsv517880 CNV loss 19592680
nsv518892 CNV loss 19592680

Variation tolerance for SCRN2 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCRN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCRN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRN2 Gene

Disorders for SCRN2 Gene

Relevant External Links for SCRN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCRN2

No disorders were found for SCRN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCRN2 Gene

Publications for SCRN2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. (PMID: 12221138) Way G. … O'Sullivan A.J. (Mol. Biol. Cell 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for SCRN2 Gene

Sources for SCRN2 Gene

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