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Aliases for SCRN1 Gene

Aliases for SCRN1 Gene

  • Secernin 1 2 3 5
  • KIAA0193 4
  • SES1 3

External Ids for SCRN1 Gene

Previous GeneCards Identifiers for SCRN1 Gene

  • GC07M029703
  • GC07M029732

Summaries for SCRN1 Gene

Entrez Gene Summary for SCRN1 Gene

  • This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

GeneCards Summary for SCRN1 Gene

SCRN1 (Secernin 1) is a Protein Coding gene. Diseases associated with SCRN1 include colonic benign neoplasm. GO annotations related to this gene include dipeptidase activity. An important paralog of this gene is SCRN2.

UniProtKB/Swiss-Prot for SCRN1 Gene

  • Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).

Gene Wiki entry for SCRN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRN1 Gene

Genomics for SCRN1 Gene

Regulatory Elements for SCRN1 Gene

Promoters for SCRN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCRN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCRN1 Gene

Chromosome:
7
Start:
29,920,103 bp from pter
End:
29,990,289 bp from pter
Size:
70,187 bases
Orientation:
Minus strand

Genomic View for SCRN1 Gene

Genes around SCRN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRN1 Gene

Proteins for SCRN1 Gene

  • Protein details for SCRN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12765-SCRN1_HUMAN
    Recommended name:
    Secernin-1
    Protein Accession:
    Q12765
    Secondary Accessions:
    • A8K0E9
    • B4DHM0
    • B4DIP5
    • C9JPG0
    • Q25QX7
    • Q8IWD1

    Protein attributes for SCRN1 Gene

    Size:
    414 amino acids
    Molecular mass:
    46382 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Secern is an archaic English term meaning secrete.
    SequenceCaution:
    • Sequence=BAA12106.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SCRN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCRN1 Gene

Proteomics data for SCRN1 Gene at MOPED

Post-translational modifications for SCRN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SCRN1

No data available for DME Specific Peptides for SCRN1 Gene

Domains & Families for SCRN1 Gene

Protein Domains for SCRN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCRN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q12765

UniProtKB/Swiss-Prot:

SCRN1_HUMAN :
  • Belongs to the peptidase C69 family. Secernin subfamily.
Family:
  • Belongs to the peptidase C69 family. Secernin subfamily.
genes like me logo Genes that share domains with SCRN1: view

No data available for Gene Families for SCRN1 Gene

Function for SCRN1 Gene

Molecular function for SCRN1 Gene

UniProtKB/Swiss-Prot Function:
Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).

Gene Ontology (GO) - Molecular Function for SCRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SCRN1: view
genes like me logo Genes that share phenotypes with SCRN1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRN1 Gene

Localization for SCRN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRN1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCRN1 Gene COMPARTMENTS Subcellular localization image for SCRN1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for SCRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SCRN1: view

Pathways & Interactions for SCRN1 Gene

SuperPathways for SCRN1 Gene

No Data Available

Interacting Proteins for SCRN1 Gene

Gene Ontology (GO) - Biological Process for SCRN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCRN1 Gene

Drugs & Compounds for SCRN1 Gene

(1) Drugs for SCRN1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SCRN1: view

Transcripts for SCRN1 Gene

Unigene Clusters for SCRN1 Gene

Secernin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCRN1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for SCRN1 Gene

GeneLoc Exon Structure for
SCRN1
ECgene alternative splicing isoforms for
SCRN1

Expression for SCRN1 Gene

mRNA expression in normal human tissues for SCRN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCRN1 Gene

This gene is overexpressed in Spinal cord (8.8), Testis (8.6), and Retina (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCRN1 Gene



SOURCE GeneReport for Unigene cluster for SCRN1 Gene Hs.520740

genes like me logo Genes that share expression patterns with SCRN1: view

Protein tissue co-expression partners for SCRN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCRN1 Gene

Orthologs for SCRN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCRN1 35
  • 98.85 (n)
  • 98.16 (a)
SCRN1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCRN1 36
  • 90 (a)
OneToOne
SCRN1 35
  • 89.37 (n)
  • 90.1 (a)
dog
(Canis familiaris)
Mammalia SCRN1 35
  • 90.5 (n)
  • 91.3 (a)
mouse
(Mus musculus)
Mammalia Scrn1 16
Scrn1 36
  • 88 (a)
OneToOne
Scrn1 35
  • 86.63 (n)
  • 87.92 (a)
oppossum
(Monodelphis domestica)
Mammalia SCRN1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCRN1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scrn1 35
  • 87.2 (n)
  • 89.86 (a)
chicken
(Gallus gallus)
Aves SCRN1 36
  • 80 (a)
OneToOne
SCRN1 35
  • 75.44 (n)
  • 80.43 (a)
lizard
(Anolis carolinensis)
Reptilia SCRN1 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18022 35
tropical clawed frog
(Silurana tropicalis)
Amphibia scrn1 35
  • 68.88 (n)
  • 64.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10098 36
  • 27 (a)
OneToMany
Species with no ortholog for SCRN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCRN1 Gene

ENSEMBL:
Gene Tree for SCRN1 (if available)
TreeFam:
Gene Tree for SCRN1 (if available)

Paralogs for SCRN1 Gene

Paralogs for SCRN1 Gene

(2) SIMAP similar genes for SCRN1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SCRN1: view

Variants for SCRN1 Gene

Sequence variations from dbSNP and Humsavar for SCRN1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17324153 - 29,926,525(+) TCTCC(A/C/T)GGAAC reference, missense
rs35960711 - 29,940,855(+) GCTGA(A/C/T)TGCAA reference, missense
rs13834 -- 29,920,846(-) TTAGA(C/T)CTTAG utr-variant-3-prime
rs740143 -- 29,945,376(+) CTCAC(A/G)AGATC intron-variant
rs1859567 -- 29,942,178(-) TTTTT(A/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCRN1 Gene

Variant ID Type Subtype PubMed ID
nsv887900 CNV Loss 21882294
nsv830936 CNV Gain 17160897
nsv511956 CNV Loss 21212237
esv2662071 CNV Deletion 23128226

Variation tolerance for SCRN1 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCRN1 Gene

HapMap Linkage Disequilibrium report
SCRN1
Human Gene Mutation Database (HGMD)
SCRN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRN1 Gene

Disorders for SCRN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCRN1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colonic benign neoplasm
  • colon neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search SCRN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCRN1

Genetic Association Database (GAD)
SCRN1
Human Genome Epidemiology (HuGE) Navigator
SCRN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCRN1
genes like me logo Genes that share disorders with SCRN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCRN1 Gene

Publications for SCRN1 Gene

  1. Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray. (PMID: 16630140) Suda T. … Tahara H. (Cancer Sci. 2006) 3 4 23 67
  2. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. (PMID: 12221138) Way G. … O'Sullivan A.J. (Mol. Biol. Cell 2002) 2 3 23
  3. SCRN1 is a novel marker for prognosis in colorectal cancer. (PMID: 20039278) Miyoshi N. … Mori M. (J Surg Oncol 2010) 3 23
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A genetic variant of miR-148a binding site in the SCRN1 3'-UTR is associated with susceptibility and prognosis of gastric cancer. (PMID: 25399950) Song P. … Zhao Q. (Sci Rep 2014) 3

Products for SCRN1 Gene

Sources for SCRN1 Gene

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