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Aliases for SCRN1 Gene

Aliases for SCRN1 Gene

  • Secernin 1 2 3 5
  • Secernin-1 3
  • KIAA0193 4
  • SES1 3

External Ids for SCRN1 Gene

Previous GeneCards Identifiers for SCRN1 Gene

  • GC07M029703
  • GC07M029732

Summaries for SCRN1 Gene

Entrez Gene Summary for SCRN1 Gene

  • This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

GeneCards Summary for SCRN1 Gene

SCRN1 (Secernin 1) is a Protein Coding gene. Diseases associated with SCRN1 include Colonic Benign Neoplasm. Gene Ontology (GO) annotations related to this gene include dipeptidase activity. An important paralog of this gene is SCRN3.

UniProtKB/Swiss-Prot for SCRN1 Gene

  • Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).

Gene Wiki entry for SCRN1 Gene

Additional gene information for SCRN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRN1 Gene

Genomics for SCRN1 Gene

GeneHancer (GH) Regulatory Elements for SCRN1 Gene

Promoters and enhancers for SCRN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I029986 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.4 1446 3.7 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 LOC105375215 PIR35583 SCRN1 MTURN
GH07I029975 Promoter 0.6 EPDnew 550.4 +14.9 14879 0.1 RUNX3 SCRN1 FKBP14 PLEKHA8 ENSG00000238906 PIR51591 LOC105375215
GH07I030025 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.4 -37.7 -37711 5.3 PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B PLEKHA8 FKBP14 SCRN1 ENSG00000226874 ENSG00000263683 LOC105375215 DKFZP586I1420 ENSG00000231519
GH07I030224 Enhancer 1.4 FANTOM5 Ensembl ENCODE 9.8 -235.4 -235418 3 PKNOX1 ARID4B BATF IRF4 RAD21 YY1 ZNF143 ATF7 ETV6 FOS SCRN1 LOC105375215 ZNRF2 GC07M030247 LOC105375217
GH07I029956 Enhancer 0.9 FANTOM5 Ensembl ENCODE 12.6 +34.0 33957 0.5 USF1 POLR2A MAX MYC RUNX3 LOC105375215 SCRN1 PLEKHA8 FKBP14 ENSG00000238906 ENSG00000231519 PIR51591 PIR47202
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SCRN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCRN1 gene promoter:

Genomic Locations for SCRN1 Gene

Genomic Locations for SCRN1 Gene
chr7:29,920,103-29,990,289
(GRCh38/hg38)
Size:
70,187 bases
Orientation:
Minus strand
chr7:29,959,719-30,029,905
(GRCh37/hg19)

Genomic View for SCRN1 Gene

Genes around SCRN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRN1 Gene

Proteins for SCRN1 Gene

  • Protein details for SCRN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12765-SCRN1_HUMAN
    Recommended name:
    Secernin-1
    Protein Accession:
    Q12765
    Secondary Accessions:
    • A8K0E9
    • B4DHM0
    • B4DIP5
    • C9JPG0
    • Q25QX7
    • Q8IWD1

    Protein attributes for SCRN1 Gene

    Size:
    414 amino acids
    Molecular mass:
    46382 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Secern is an archaic English term meaning secrete.
    SequenceCaution:
    • Sequence=BAA12106.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SCRN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCRN1 Gene

Post-translational modifications for SCRN1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SCRN1 Gene

Domains & Families for SCRN1 Gene

Gene Families for SCRN1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SCRN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCRN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q12765

UniProtKB/Swiss-Prot:

SCRN1_HUMAN :
  • Belongs to the peptidase C69 family. Secernin subfamily.
Family:
  • Belongs to the peptidase C69 family. Secernin subfamily.
genes like me logo Genes that share domains with SCRN1: view

Function for SCRN1 Gene

Molecular function for SCRN1 Gene

UniProtKB/Swiss-Prot Function:
Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).

Phenotypes From GWAS Catalog for SCRN1 Gene

Gene Ontology (GO) - Molecular Function for SCRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0016805 dipeptidase activity IEA --
genes like me logo Genes that share ontologies with SCRN1: view
genes like me logo Genes that share phenotypes with SCRN1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRN1 Gene

Localization for SCRN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRN1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCRN1 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SCRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10942595
GO:0005737 cytoplasm IEA --
GO:0031965 nuclear membrane IDA 10942595
genes like me logo Genes that share ontologies with SCRN1: view

Pathways & Interactions for SCRN1 Gene

SuperPathways for SCRN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006887 exocytosis IBA,ISS --
genes like me logo Genes that share ontologies with SCRN1: view

No data available for Pathways by source and SIGNOR curated interactions for SCRN1 Gene

Drugs & Compounds for SCRN1 Gene

(1) Drugs for SCRN1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with SCRN1: view

Transcripts for SCRN1 Gene

Unigene Clusters for SCRN1 Gene

Secernin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRN1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for SCRN1 Gene

GeneLoc Exon Structure for
SCRN1
ECgene alternative splicing isoforms for
SCRN1

Expression for SCRN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCRN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCRN1 Gene

This gene is overexpressed in Spinal cord (8.8), Testis (8.6), and Retina (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCRN1 Gene



Protein tissue co-expression partners for SCRN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCRN1 Gene:

SCRN1

SOURCE GeneReport for Unigene cluster for SCRN1 Gene:

Hs.520740

Evidence on tissue expression from TISSUES for SCRN1 Gene

  • Nervous system(5)
  • Blood(4.1)
  • Bone marrow(4.1)
  • Lung(2.7)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with SCRN1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCRN1 Gene

Orthologs for SCRN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCRN1 33 34
  • 98.85 (n)
dog
(Canis familiaris)
Mammalia SCRN1 33
  • 90.5 (n)
cow
(Bos Taurus)
Mammalia SCRN1 33 34
  • 89.37 (n)
rat
(Rattus norvegicus)
Mammalia Scrn1 33
  • 87.2 (n)
mouse
(Mus musculus)
Mammalia Scrn1 33 16 34
  • 86.63 (n)
oppossum
(Monodelphis domestica)
Mammalia SCRN1 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCRN1 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCRN1 33 34
  • 75.44 (n)
lizard
(Anolis carolinensis)
Reptilia SCRN1 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scrn1 33
  • 68.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18022 33
fruit fly
(Drosophila melanogaster)
Insecta CG10098 34
  • 27 (a)
OneToMany
Species where no ortholog for SCRN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCRN1 Gene

ENSEMBL:
Gene Tree for SCRN1 (if available)
TreeFam:
Gene Tree for SCRN1 (if available)

Paralogs for SCRN1 Gene

Paralogs for SCRN1 Gene

(2) SIMAP similar genes for SCRN1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SCRN1: view

Variants for SCRN1 Gene

Sequence variations from dbSNP and Humsavar for SCRN1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs193920979 uncertain-significance, Malignant tumor of prostate 29,923,979(-) G/A coding_sequence_variant, missense_variant
rs864622024 uncertain-significance, Malignant tumor of prostate 29,955,342(-) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000114990 -- 29,979,831(-) A/G intron_variant
rs1000136056 -- 29,980,813(-) A/G intron_variant
rs1000155865 -- 29,990,833(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SCRN1 Gene

Variant ID Type Subtype PubMed ID
esv2662071 CNV deletion 23128226
nsv1019527 CNV gain 25217958
nsv1068321 OTHER inversion 25765185
nsv1148830 OTHER inversion 26484159
nsv511956 CNV loss 21212237
nsv830936 CNV gain 17160897

Variation tolerance for SCRN1 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCRN1 Gene

Human Gene Mutation Database (HGMD)
SCRN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCRN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRN1 Gene

Disorders for SCRN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCRN1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colonic benign neoplasm
  • colon neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search SCRN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SCRN1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SCRN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCRN1 Gene

Publications for SCRN1 Gene

  1. Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray. (PMID: 16630140) Suda T … Tahara H (Cancer science 2006) 3 4 22 58
  2. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. (PMID: 12221138) Way G … O'Sullivan AJ (Molecular biology of the cell 2002) 2 3 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. SCRN1 is a novel marker for prognosis in colorectal cancer. (PMID: 20039278) Miyoshi N … Mori M (Journal of surgical oncology 2010) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SCRN1 Gene

Sources for SCRN1 Gene

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