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Aliases for SCRN1 Gene

Aliases for SCRN1 Gene

  • Secernin 1 2 3
  • KIAA0193 4 6
  • SES1 3 6
  • Secernin-1 3

External Ids for SCRN1 Gene

Previous GeneCards Identifiers for SCRN1 Gene

  • GC07M029703
  • GC07M029732

Summaries for SCRN1 Gene

Entrez Gene Summary for SCRN1 Gene

  • This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

GeneCards Summary for SCRN1 Gene

SCRN1 (Secernin 1) is a Protein Coding gene. GO annotations related to this gene include dipeptidase activity. An important paralog of this gene is SCRN2.

UniProtKB/Swiss-Prot for SCRN1 Gene

  • Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).

Gene Wiki entry for SCRN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRN1 Gene

Genomics for SCRN1 Gene

Regulatory Elements for SCRN1 Gene

Genomic Location for SCRN1 Gene

Start:
29,920,103 bp from pter
End:
29,990,289 bp from pter
Size:
70,187 bases
Orientation:
Minus strand

Genomic View for SCRN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCRN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRN1 Gene

Proteins for SCRN1 Gene

  • Protein details for SCRN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12765-SCRN1_HUMAN
    Recommended name:
    Secernin-1
    Protein Accession:
    Q12765
    Secondary Accessions:
    • A8K0E9
    • B4DHM0
    • B4DIP5
    • C9JPG0
    • Q25QX7
    • Q8IWD1

    Protein attributes for SCRN1 Gene

    Size:
    414 amino acids
    Molecular mass:
    46382 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Secern is an archaic English term meaning secrete
    SequenceCaution:
    • Sequence=BAA12106.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SCRN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCRN1 Gene

Proteomics data for SCRN1 Gene at MOPED

Post-translational modifications for SCRN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCRN1 Gene

Domains for SCRN1 Gene

Protein Domains for SCRN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCRN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q12765

UniProtKB/Swiss-Prot:

SCRN1_HUMAN :
  • Q12765
Family:
  • Belongs to the peptidase C69 family. Secernin subfamily.
genes like me logo Genes that share domains with SCRN1: view

No data available for Gene Families for SCRN1 Gene

Function for SCRN1 Gene

Molecular function for SCRN1 Gene

UniProtKB/Swiss-Prot Function: Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).

Gene Ontology (GO) - Molecular Function for SCRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0016805 dipeptidase activity IEA --
genes like me logo Genes that share ontologies with SCRN1: view

miRNA for SCRN1 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCRN1 Gene

Localization for SCRN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRN1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCRN1 Gene COMPARTMENTS Subcellular localization image for SCRN1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SCRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10942595
GO:0005737 cytoplasm IEA --
GO:0031965 nuclear membrane IDA 10942595
genes like me logo Genes that share ontologies with SCRN1: view

Pathways for SCRN1 Gene

SuperPathways for SCRN1 Gene

No Data Available

Interacting Proteins for SCRN1 Gene

Gene Ontology (GO) - Biological Process for SCRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006887 exocytosis ISS --
genes like me logo Genes that share ontologies with SCRN1: view

No data available for Pathways by source for SCRN1 Gene

Compounds for SCRN1 Gene

(1) HMDB Compounds for SCRN1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with SCRN1: view

Transcripts for SCRN1 Gene

Unigene Clusters for SCRN1 Gene

Secernin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCRN1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for SCRN1 Gene

GeneLoc Exon Structure for
SCRN1
ECgene alternative splicing isoforms for
SCRN1

Expression for SCRN1 Gene

mRNA expression in normal human tissues for SCRN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCRN1 Gene

SOURCE GeneReport for Unigene cluster for SCRN1 Gene Hs.520740

genes like me logo Genes that share expressions with SCRN1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCRN1 Gene

Orthologs for SCRN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCRN1 35
  • 98.85 (n)
  • 98.16 (a)
SCRN1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCRN1 35
  • 89.37 (n)
  • 90.1 (a)
SCRN1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCRN1 35
  • 90.5 (n)
  • 91.3 (a)
mouse
(Mus musculus)
Mammalia Scrn1 35
  • 86.63 (n)
  • 87.92 (a)
Scrn1 16
Scrn1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCRN1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCRN1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scrn1 35
  • 87.2 (n)
  • 89.86 (a)
chicken
(Gallus gallus)
Aves SCRN1 35
  • 75.44 (n)
  • 80.43 (a)
SCRN1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCRN1 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18022 35
tropical clawed frog
(Silurana tropicalis)
Amphibia scrn1 35
  • 68.88 (n)
  • 64.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10098 36
  • 27 (a)
OneToMany
Species with no ortholog for SCRN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCRN1 Gene

ENSEMBL:
Gene Tree for SCRN1 (if available)
TreeFam:
Gene Tree for SCRN1 (if available)

Paralogs for SCRN1 Gene

Paralogs for SCRN1 Gene

Selected SIMAP similar genes for SCRN1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SCRN1: view

Variants for SCRN1 Gene

Sequence variations from dbSNP and Humsavar for SCRN1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4662 -- 29,920,903(-) ACCTG(G/T)TGTTA utr-variant-3-prime
rs9912 -- 29,920,595(-) CTTAG(G/T)AAGGA utr-variant-3-prime
rs13834 -- 29,920,846(-) TTAGA(C/T)CTTAG utr-variant-3-prime
rs14593 -- 29,920,481(-) CTTCC(A/C)GTAGC utr-variant-3-prime
rs740143 -- 29,945,376(+) CTCAC(A/G)AGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCRN1 Gene

Variant ID Type Subtype PubMed ID
nsv887900 CNV Loss 21882294
nsv830936 CNV Gain 17160897
nsv511956 CNV Loss 21212237
esv2662071 CNV Deletion 23128226

Relevant External Links for SCRN1 Gene

HapMap Linkage Disequilibrium report
SCRN1
Human Gene Mutation Database (HGMD)
SCRN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRN1 Gene

Disorders for SCRN1 Gene

Relevant External Links for SCRN1

Genetic Association Database (GAD)
SCRN1
Human Genome Epidemiology (HuGE) Navigator
SCRN1
genes like me logo Genes that share disorders with SCRN1: view

No data available for UniProtKB/Swiss-Prot for SCRN1 Gene

Publications for SCRN1 Gene

  1. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. (PMID: 12221138) Way G. … O'Sullivan A.J. (Mol. Biol. Cell 2002) 2 3 23
  2. Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray. (PMID: 16630140) Suda T. … Tahara H. (Cancer Sci. 2006) 3 4 23
  3. SCRN1 is a novel marker for prognosis in colorectal cancer. (PMID: 20039278) Miyoshi N. … Mori M. (J Surg Oncol 2010) 3 23
  4. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  5. Towards complete analysis of the platelet proteome. (PMID: 11921445) O'Neill E.E. … Hebestreit H.F. (Proteomics 2002) 3 4

Products for SCRN1 Gene

Sources for SCRN1 Gene

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