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SCRIB Gene

protein-coding   GIFtS: 66
GCID: GC08M144874

Scribbled Planar Cell Polarity Protein

(Previous name: scribbled homolog (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Scribbled Planar Cell Polarity Protein1 2     Protein Scribble Homolog2
SCRB12 3 5     Scribbled Homolog2
CRIB12 3     LAP43
KIAA01473 5     Scribble3
Scribbled Homolog (Drosophila)1     VARTUL3
SCRIB12     hScrib3
Vartul2     Protein LAP43

External Ids:    HGNC: 303771   Entrez Gene: 235132   Ensembl: ENSG000001809007   OMIM: 6077335   UniProtKB: Q141603   

Export aliases for SCRIB gene to outside databases

Previous GC identifers: GC08U990087 GC08M145136 GC08M144648 GC08M144979 GC08M144945 GC08M140127


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCRIB Gene:
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian
protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes,
this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ
domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein
isoforms have been found for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for SCRIB Gene:
SCRIB (scribbled planar cell polarity protein) is a protein-coding gene. Diseases associated with SCRIB include spina bifida, and craniorachischisis. An important paralog of this gene is LRRC8E.

UniProtKB/Swiss-Prot: SCRIB_HUMAN, Q14160
Function: Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial
and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May
function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis
for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and
adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the
targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity

Gene Wiki entry for SCRIB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  NT_187571.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCRIB gene promoter:
         E2F-4   E2F-3a   E2F-5   FOXF2   HTF   E2F-2   YY1   c-Ets-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCRIB promoter sequence
   Search Chromatin IP Primers for SCRIB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCRIB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

SCRIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCRIB gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M144874:  view genomic region     (about GC identifiers)

Start:
144,873,090 bp from pter      End:
144,897,549 bp from pter
Size:
24,460 bases      Orientation:
minus strand

1 alternative location:
Chr8-,NW_003315923 129,565-154,024     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SCRIB_HUMAN, Q14160 (See protein sequence)
Recommended Name: Protein scribble homolog  
Size: 1630 amino acids; 174885 Da
Subunit: Interacts (via PDZ domains) with VANGL2. Interacts with CTNNB1 and MAPK12 (By similarity). Interacts with
UBE3A and HPV E6. Interacts with PAK1 and PAK2. Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7.
Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct. Interacts (via PDZ domains) with TJP2.
Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells.
Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function. Interacts (via PDZ domains 1 and
3) with MCC. Interacts (via fourth PDZ domain) with tick-borne encephalitis virus NS5 protein; this interaction
inhibits SCRIB and downstream STAT1 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway
4 PDB 3D structures from and Proteopedia for SCRIB:
1UJU (3D)        1WHA (3D)        1X5Q (3D)        2W4F (3D)    
Secondary accessions: Q6P496 Q7Z5D1 Q8WWV8 Q96C69 Q96GG1
Alternative splicing: 3 isoforms:  Q14160-1   Q14160-2   Q14160-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCRIB: NX_Q14160

Explore proteomics data for SCRIB at MOPED

Post-translational modifications: 

  • Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and
    degraded1
  • Ubiquitination2 at Lys53, Lys63, Lys164, Lys266, Lys272
  • Modification sites at PhosphoSitePlus

  • See SCRIB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056171.3  NP_874365.3  

    ENSEMBL proteins: 
     ENSP00000349486   ENSP00000322938   ENSP00000431519   ENSP00000366756   ENSP00000433546  
    Reactome Protein details: Q14160

    SCRIB Human Recombinant Protein Products:

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    SCRIB Antibody Products:

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    SCRIB Assay Products:

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    Cloud-Clone Corp. ELISAs for SCRIB
    Cloud-Clone Corp. CLIAs for SCRIB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q14160

    ProtoNet protein and cluster: Q14160

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: SCRIB_HUMAN, Q14160
    Similarity: Belongs to the LAP (LRR and PDZ) protein family
    Similarity: Contains 16 LRR (leucine-rich) repeats
    Similarity: Contains 4 PDZ (DHR) domains


    SCRIB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCRIB_HUMAN, Q14160
    Function: Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial
    and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May
    function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis
    for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and
    adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the
    targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15182672
         
    SCRIB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SCRIB:
     Decreased Wnt reporter activit 

         13 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Scrib):
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     limbs/digits/tail  mortality/aging  nervous system  renal/urinary system  reproductive system 
     respiratory system  tumorigenesis  vision/eye 

    SCRIB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SCRIB: Scribtm1.2Phum Scribtm1.2Geno

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCRIB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SCRIB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCRIB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCRIB

    miRNA
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    miRTarBase miRNAs that target SCRIB:
    hsa-mir-186-5p (MIRT044993), hsa-mir-296-5p (MIRT006438), hsa-mir-93-3p (MIRT038838), hsa-mir-193b-3p (MIRT041556), hsa-mir-766-3p (MIRT039044), hsa-mir-877-3p (MIRT037202)

    Block miRNA regulation of human, mouse, rat SCRIB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCRIB (see all 12):
    hsa-miR-34c-3p hsa-miR-499-3p hsa-let-7a-2* hsa-miR-323b-5p hsa-miR-582-5p hsa-miR-659 hsa-miR-9 hsa-miR-493*
    SwitchGear 3'UTR luciferase reporter plasmidSCRIB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SCRIB

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SCRIB (NM_182706)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCRIB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCRIB

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCRIB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCRIB_HUMAN, Q14160: Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell
    projection, lamellipodium. Cytoplasm. Note=Targeting to cell-cell junctions which is CDH1-dependent is required
    for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886colocalizes with plasma membrane IDA16611247
    GO:0005911cell-cell junction IDA15649318
    GO:0005913cell-cell adherens junction IDA16965391
    GO:0016323basolateral plasma membrane IEA--

    SCRIB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SCRIB About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Signaling by Wnt0.79
    2CDK-mediated phosphorylation and removal of Cdc6
    Asymmetric localization of PCP proteins0.75
    PCP/CE pathway0.70
    3Signaling by GPCR
    Signal Transduction0.58
    4Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    5Viral carcinogenesis
    Viral carcinogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for SCRIB
        Wnt / Hedgehog / Notch
    Cytoskeletal Signaling
    Adhesion

    1 BioSystems Pathway for SCRIB
        TSH signaling pathway

    1 Reactome Pathway for SCRIB
        Asymmetric localization of PCP proteins


    2 Kegg Pathways  (Kegg details for SCRIB):
        Hippo signaling pathway
    Viral carcinogenesis


    SCRIB for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCRIB
    Interactions:

        GeneGlobe Interaction Network for SCRIB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SCRIB (Q141601, 2, 3 ENSP000003494864) via UniProtKB, MINT, STRING, and/or I2D (see all 642)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF7Q141551, 2, 3, ENSP000003648934EBI-357345,EBI-717515 MINT-62243 MINT-62246 MINT-7210759 MINT-62247 MINT-8114729 MINT-62244 MINT-62254 MINT-62250 MINT-7210792 I2D: score=4 STRING: ENSP00000364893
    MCCP235081, 2, 3, ENSP000003862274EBI-357345,EBI-307531 MINT-7210634 MINT-7210690 MINT-7210609 MINT-7210820 MINT-7211237 MINT-7211022 MINT-7210883 MINT-7210731 I2D: score=1 STRING: ENSP00000386227
    E6P064631, 2EBI-357345,EBI-1186926 MINT-7211267 MINT-74959 MINT-74958 EBI-357345,EBI-1177242 MINT-6732440 MINT-6732409 MINT-68734 MINT-74955 MINT-74960 MINT-74961
    APCP250541, 2, 3, ENSP000002574304EBI-357345,EBI-727707 MINT-6732435 MINT-6732416 MINT-6732421 MINT-6732428 I2D: score=1 STRING: ENSP00000257430
    PHLPP1O603461, 2, 3EBI-357345,EBI-2511516 MINT-8204981 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure IMP--
    GO:0001921positive regulation of receptor recycling IMP15775968
    GO:0008105asymmetric protein localization IEA--
    GO:0008283cell proliferation IDA16965391
    GO:0016032viral process IEA--

    SCRIB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCRIB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SCRIB gene (2 alternative transcripts): 
    NM_015356.4  NM_182706.4  

    Unigene Cluster for SCRIB:

    Scribbled planar cell polarity protein
    Hs.436329  [show with all ESTs]
    Unigene Representative Sequence: NM_182706
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356994(uc003yzo.1) ENST00000320476(uc003yzp.1) ENST00000531163
    ENST00000525051 ENST00000526832(uc003yzn.1) ENST00000377533 ENST00000546337
    ENST00000531942
    miRNA
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    hsa-miR-34c-3p hsa-miR-499-3p hsa-let-7a-2* hsa-miR-323b-5p hsa-miR-582-5p hsa-miR-659 hsa-miR-9 hsa-miR-493*
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    GenScript: all cDNA clones in your preferred vector (see all 2): SCRIB (NM_182706)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCRIB
    Primer
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    Additional mRNA sequence: 

    AF240677.1 AF271734.2 AY062238.1 BC009490.2 BC014632.2 BC026045.1 BC036905.1 BC044627.1 
    D63481.3 

    10 DOTS entries:

    DT.312144  DT.95276515  DT.100029345  DT.101984462  DT.100666541  DT.120643232  DT.100029344  DT.91770063 
    DT.95179026  DT.95276517 

    Selected AceView cDNA sequences (see all 218):

    BE464734 AI739259 BF312996 AI591130 BC009490 BC044627 BU956075 BP430727 
    F27752 BC014632 AI652051 BQ639024 BF059264 BU857279 AI587515 AA962100 
    BC036905 BM763346 BC063590 BU161114 BU155766 BQ897964 AW015755 BU176166 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SCRIB (see all 17)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35a · 35b · 35c · 35d ^ 36 ^ 37 ^ 38 ^
    SP1:                                                                                -                                                                           
    SP2:                                                                                -                                                                           
    SP3:                                                                                -                                                                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 39 ^ 40a · 40b · 40c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SCRIB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCRIB expression in normal human tissues (normalized intensities)      SCRIB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCACGCCGT
    SCRIB Expression
    About this image


    SCRIB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
    SCRIB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCRIB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436329

    UniProtKB/Swiss-Prot: SCRIB_HUMAN, Q14160
    Tissue specificity: Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin
    mainly in epithelial cells (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SCRIB gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scrib1 , 5 scribbled homolog (Drosophila)1, 5 81.85(n)1
    86.71(a)1
      15 (35.29 cM)5
    1057821  NM_134089.11  NP_598850.11 
     760471585 
    chicken
    (Gallus gallus)
    Aves SCRIB6
    scribbled planar cell polarity protein
    69(a)
    1 ↔ 1
    2(148587858-148720614)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia scrib1 scribbled planar cell polarity protein 70.7(n)
    74(a)
      100494581  NM_001256291.1  NP_001243220.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scrib1 scribbled homolog (Drosophila) 65.31(n)
    66.38(a)
      368473  NM_001007175.1  NP_001007176.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta scrib6
    scribbled
    27(a)
    1 → many
    3R(22362072-22429773)
    worm
    (Caenorhabditis elegans)
    Secernentea let-4131 , 3 Expression: nerve ring, spermathecae,
    uterus, more3
    let-4131
    45(a)3
    46.86(n)1
    42.7(a)1
      V(7976575-7980226)3
    1791711  NM_001028680.31  NP_001023851.11 


    ENSEMBL Gene Tree for SCRIB (if available)
    TreeFam Gene Tree for SCRIB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCRIB gene
    LRRC8E2  LRRC72  ERBB2IP2  RSU12  LRRC8A2  MFHAS12  LRRC12  LRRIQ42  
    SHOC22  LRRD12  LRRC8D2  LRRC8B2  LRRC8C2  LRRC402  
    Selected SIMAP similar genes for SCRIB using alignment to 4 protein entries:     SCRIB_HUMAN (see all proteins) (see all similar genes):
    LRRC1    LRRC7    SYNJ2BP    LRRC8B    pp6170    DLG4
    ARHGAP23    TAX1BP3    FRMPD2    MAGI1    MPDZ    LRIG3
    LRRC57    LRRD1    TJP2    DLG2    PDLIM7    LRRC28

    SCRIB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCRIB (see all 1014)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0672204
    Neural tube defects (NTD)4--see VAR_0672202 R Q mis40--------
    VAR_0672194
    Neural tube defects (NTD)4--see VAR_0672192 P S mis40--------
    rs2003452751,2
    --140152510(+) AAAGTA/GCCCAG 2 -- int10--------
    rs346902951,2
    C--144883137(+) ACACA-/TTGACA 2 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs114045661,2
    C--144894702(+) TTGCCT/-CCACA 4 -- int13Minor allele frequency- -:0.12CSA 8
    rs1998695701,2
    C--145133455(+) GCGGT-/GCAGCAGG 2 -- cds10--------
    rs1123944971,2
    C--145133459(+) GTGCAG/AGAGAG 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1450573331,2
    C--145133673(+) TGCCCC/TGGGGC 2 -- ds50010--------
    rs1848645601,2
    --145133679(+) GGGGCA/GCGGTG 2 -- ds50010--------
    rs1475861241,2
    --145133708(+) CGTGGA/GGGCAG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SCRIB (144873090 - 144897549 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SCRIB (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738038CNV Deletion23290073
    nsv398483CNV Insertion16902084
    dgv7945n71CNV Loss21882294
    dgv7946n71CNV Loss21882294
    nsv891751CNV Loss21882294
    nsv891766CNV Loss21882294
    nsv6442CNV Loss18451855
    dgv7943n71CNV Loss21882294
    dgv7939n71CNV Loss21882294
    dgv7935n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): SCRIB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCRIB
    DNA2.0 Custom Variant and Variant Library Synthesis for SCRIB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607733    OMIM disorders: --

    UniProtKB/Swiss-Prot: SCRIB_HUMAN, Q14160
  • Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and
    adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of
    neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly,
    myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of
    the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 19 diseases for SCRIB:    About MalaCards
    spina bifida    craniorachischisis    tick-borne encephalitis    avian influenza
    neural tube defects    typhus    scrub typhus    strabismus
    human t-cell leukemia virus type 1    influenza    encephalitis    t-cell leukemia
    leukemia    breast cancer    multiple myeloma    myeloma
    prostate cancer    prostatitis    neuronitis


    SCRIB for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SCRIB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 16137684 (2), 15649318 (2), 17509663 (1)

    Human Genome Epidemiology (HuGE) Navigator: SCRIB (1 document)

    Export disorders for SCRIB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCRIB gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with SCRIB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. (PubMed id 11027293)1, 2, 3 Nakagawa S. and Huibregtse J.M. (Mol. Cell. Biol. 2000)
    2. The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus. (PubMed id 15649318)1, 2, 9 Petit M.M.R....Van de Ven W.J.M. (BMC Cell Biol. 2005)
    3. hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. (PubMed id 14681682)1, 3, 9 Dow L.E....Humbert P.O. (Oncogene 2003)
    4. The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins. (PubMed id 16137684)1, 2, 9 Petit M.M.R....Van de Ven W.J.M. (FEBS Lett. 2005)
    5. Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1- ARF6 pathway. (PubMed id 15775968)1, 2, 9 Lahuna O.... Misrahi M. (EMBO J. 2005)
    6. Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis. (PubMed id 22095531)1, 2 Robinson A.... Stanier P. (Hum. Mutat. 2012)
    7. MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. (PubMed id 19555689)1, 2 Arnaud C....Lecine P. (FEBS Lett. 2009)
    8. Scrib regulates PAK activity during the cell migration process. (PubMed id 18716323)1, 2 Nola S.... Santoni M.-J. (Hum. Mol. Genet. 2008)
    9. Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling. (PubMed id 18641685)1, 2 Dow L.E....Humbert P.O. (Oncogene 2008)
    10. Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling. (PubMed id 18042258)1, 2 Werme K.... Johansson M. (Cell. Microbiol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23513 HGNC: 30377 AceView: SCRIB Ensembl:ENSG00000180900 euGenes: HUgn23513
    ECgene: SCRIB Kegg: 23513 H-InvDB: SCRIB

    (According to HUGE)
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    HUGE: KIAA0147

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SCRIB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SCRIB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCRIB gene:
    Search GeneIP for patents involving SCRIB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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