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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SCRIB Gene

protein-coding GIFtS: 61
GCID: GC08M144874

scribbled homolog (Drosophila)

Explore 19 diseases affiliated with
SCRIB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Scribbled Homolog (Drosophila)¹ ²		Protein Scribble Homolog²
SCRB1¹ ² ³ ⁵		LAP4³
KIAA0147¹ ³ ⁵		Scribble³
Vartul¹ ²		VARTUL³
CRIB1² ³		HScrib¹
SCRIB1²		Protein LAP4³

External Ids:	HGNC: 30377¹	Entrez Gene: 23513²	Ensembl: ENSG00000180900⁷	OMIM: 607733⁵	UniProtKB: Q14160³

Export aliases for SCRIB gene to outside databases

Previous GC identifers: GC08U990087 GC08M145136 GC08M144648 GC08M144979 GC08M144945 GC08M140127

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCRIB:

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian

protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this

protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and

the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been

found for this gene. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: SCRIB_HUMAN, Q14160

Function: Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and

neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in

cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance

during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence

regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to

synapses. Functions as an activator of Rac GTPase activity

Gene Wiki entry for SCRIB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SCRIB gene promoter:
E2F-4 E2F-3a E2F-5 FOXF2 HTF E2F-2 YY1 c-Ets-1 E2F E2F-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCRIB promoter sequence

Search SABiosciences Chromatin IP Primers for SCRIB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCRIB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3

SCRIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCRIB gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M144874: view genomic region (about GC identifiers)

Start:	144,873,090 bp from pter	End:	144,897,549 bp from pter
Size:	24,460 bases	Orientation:	minus strand

1 alternative location:

Chr8-,PATCHES 144,859,455-144,883,914

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SCRIB_HUMAN, Q14160 (See protein sequence)

Recommended Name: Protein scribble homolog

Size: 1630 amino acids; 174885 Da

Subunit: Interacts (via PDZ domains) with VANGL2. Interacts with CTNNB1 and MAPK12 (By similarity). Interacts with

UBE3A and HPV E6. Interacts with PAK1 and PAK2. Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7.

Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct. Interacts (via PDZ domains) with TJP2.

Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells. Interacts

(via PDZ domains) with TSHR; regulates TSHR trafficking and function. Interacts with MCC. Interacts (via fourth PDZ

domain) with tick-borne encephalitis virus NS5 protein; this interaction inhibits SCRIB and downstream STAT1

phosphorylation, thereby preventing activation of JAK-STAT signaling pathway

Subcellular location: Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cytoplasm.

Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to

neuronal post- and pre-synaptic regions

4 PDB 3D structures from and Proteopedia for SCRIB:

1UJU (3D)

1WHA (3D)

1X5Q (3D)

2W4F (3D)

Secondary accessions: Q6P496 Q7Z5D1 Q8WWV8 Q96C69 Q96GG1

Alternative splicing: 3 isoforms: Q14160-1 Q14160-2 Q14160-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCRIB: NX_Q14160

Post-translational modifications:

Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and

degraded¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14160

SCRIB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_056171.3 NP_874365.3

ENSEMBL proteins:

ENSP00000349486 ENSP00000322938 ENSP00000431519 ENSP00000366756 ENSP00000433546

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SCRIB

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	colocalizes with plasma membrane	IDA	16611247
GO:0005911	cell-cell junction	IDA	15649318
GO:0005913	cell-cell adherens junction	IDA	16965391
GO:0016323	basolateral plasma membrane	IEA	--
GO:0031252	colocalizes with cell leading edge	IDA	18716323

SCRIB for ontologies About GeneDecksing

SCRIB Antibody Products:

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	GenScript Superior Antibodies for SCRIB
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Assay Products for SCRIB:

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	GenScript Custom Assay Services for SCRIB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SCRIB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SCRIB for domains About GeneDecksing

4 InterPro domains/families:

IPR001611 Leu-rich_rpt

IPR025875 Leu-rich_rpt_4

IPR001478 PDZ

IPR003591 Leu-rich_rpt_typical-subtyp

Graphical View of Domain Structure for InterPro Entry Q14160

ProtoNet protein and cluster: Q14160

1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain

UniProtKB/Swiss-Prot: SCRIB_HUMAN, Q14160

Similarity: Belongs to the LAP (LRR and PDZ) protein family

Similarity: Contains 16 LRR (leucine-rich) repeats

Similarity: Contains 4 PDZ (DHR) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SCRIB_HUMAN, Q14160

Function: Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and

neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in

cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance

during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence

regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to

synapses. Functions as an activator of Rac GTPase activity

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SCRIB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCRIB
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SCRIB (see all 12):
		hsa-miR-34c-3p hsa-miR-499-3p hsa-let-7a-2* hsa-miR-323b-5p hsa-miR-582-5p hsa-miR-659 hsa-miR-9 hsa-miR-493*

		SwitchGear 3'UTR luciferase reporter plasmid: SCRIB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SCRIB
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCRIB

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16611247

SCRIB for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SCRIB:

Decreased Wnt reporter activit

Animal Models:
Mouse knock-outs for SCRIB: Scrib^tm1.2Phum Scrib^tm1.2Geno
13 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Scrib):

digestive/alimentary	embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear
limbs/digits/tail	mortality/aging	nervous system	renal/urinary system	reproductive system
respiratory system	tumorigenesis	vision/eye

SCRIB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

Adhesion

Adhesion

1.00

TSH signaling pathway

TSH signaling pathway

1.00

Wnt / Hedgehog / Notch

Wnt / Hedgehog / Notch

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Cell Signaling Technology (CST) Pathways for SCRIB

	Wnt / Hedgehog / Notch
	Cytoskeletal Signaling
	Adhesion

1 BioSystems Pathway for SCRIB

TSH signaling pathway

SCRIB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SCRIB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/580 Interacting proteins for SCRIB (Q14160^{1, 2, 3} ENSP00000349486⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 580)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARHGEF7	Q14155²^,³, ENSP00000364893⁴	MINT-62243 MINT-62246 MINT-7210759 MINT-62247 MINT-8114729 MINT-62244 MINT-62254 MINT-62250 MINT-7210792 I2D: score=4 STRING: ENSP00000364893
MCC	P23508²^,³, ENSP00000386227⁴	MINT-7210634 MINT-7210690 MINT-7210609 MINT-7210820 MINT-7211237 MINT-7211022 MINT-7210883 MINT-7210731 I2D: score=1 STRING: ENSP00000386227
TRIP6	Q15654²^,³, ENSP00000200457⁴	MINT-62865 MINT-62864 MINT-62863 MINT-62866 I2D: score=2 STRING: ENSP00000200457
APC	P25054²^,³, ENSP00000257430⁴	MINT-6732435 MINT-6732416 MINT-6732421 MINT-6732428 I2D: score=1 STRING: ENSP00000257430
MAPK3	P27361¹^,³, ENSP00000263025⁴	EBI-357345,EBI-73995 I2D: score=2 STRING: ENSP00000263025

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001843	neural tube closure	IMP	--
GO:0001921	positive regulation of receptor recycling	IMP	15775968
GO:0008105	asymmetric protein localization	IEA	--
GO:0008283	cell proliferation	IDA	16965391
GO:0016080	synaptic vesicle targeting	IEA	--

SCRIB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SCRIB
Search CenterWatch for drugs/clinical trials and news about SCRIB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SCRIB gene (2 alternative transcripts):

NM_015356.4 NM_182706.4

Unigene Cluster for SCRIB:

Scribbled homolog (Drosophila)

Hs.436329 [show with all ESTs]

Unigene Representative Sequence: NM_182706

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000356994(uc003yzo.1) ENST00000320476(uc003yzp.1) ENST00000531163

ENST00000525051 ENST00000526832(uc003yzn.1) ENST00000377533 ENST00000546337

ENST00000531942

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCRIB
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SCRIB (see all 12):
		hsa-miR-34c-3p hsa-miR-499-3p hsa-let-7a-2* hsa-miR-323b-5p hsa-miR-582-5p hsa-miR-659 hsa-miR-9 hsa-miR-493*

		SwitchGear 3'UTR luciferase reporter plasmid: SCRIB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCRIB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCRIB

Additional cDNA sequence:

AF240677.1 AF271734.2 AY062238.1 BC009490.2 BC014632.2 BC026045.1 BC036905.1 BC044627.1

D63481.3

10 DOTS entries:

DT.312144 DT.95276515 DT.100029345 DT.101984462 DT.100666541 DT.120643232 DT.100029344 DT.91770063

DT.95179026 DT.95276517

24/218 AceView cDNA sequences (see all 218):

BQ897964 BC063590 BU155766 BC044627 BU176166 BC009490 BE464734 BP430727

BC014632 BU956075 BC036905 BP430224 BU161114 AA962100 BF059264 AI652051

AI587515 BQ639024 BM763346 AI591130 AW015755 F27752 BF312996 AI739259

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for SCRIB (see all 17) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	^	13a	·	13b	·	13c	^	14	^	15	^	16	^	17	^	18	^	19	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	20	^	21	^	22	^	23	^	24a	·	24b	^	25	^	26a	·	26b	^	27a	·	27b	^	28	^	29	^	30	^	31	^	32	^	33a	·	33b	^	34	^	35a	·	35b	·	35c	·	35d	^	36	^	37	^	38	^
SP1:																											-
SP2:																											-
SP3:																											-
SP4:
SP5:

ExUns:	39	^	40a	·	40b	·	40c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SCRIB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCRIB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCACGCCGT

About this image
See SCRIB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCRIB

SOURCE GeneReport for Unigene cluster: Hs.436329

UniProtKB/Swiss-Prot: SCRIB_HUMAN, Q14160

Tissue specificity: Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in

epithelial cells (at protein level)

SABiosciences Custom PCR Arrays for SCRIB

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCRIB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCRIB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SCRIB gene from 4/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	SCRIB¹	scribbled homolog (Drosophila)	68.05(n) 69.54(a)	429470 XM_427026.3 XP_427026.3
zebrafish (Danio rerio)	Actinopterygii	scrib¹	scribbled homolog (Drosophila)	64.23(n) 64.85(a)	368473 NM_001007175.1 NP_001007176.1
fruit fly (Drosophila melanogaster)	Insecta	scrib¹	scribbled	55.02(n) 49.08(a)	44448 NM_001170276.2 NP_001163747.1
worm (Caenorhabditis elegans)	Secernentea	let-413^{1 , 3}	Expression: nerve ring, spermathecae, uterus, more³ Protein LET-413¹	45(a)³ 44.55(n)¹ 39.97(a)¹	V(7976575-7980226)³ 179171¹ NM_001028680.2¹ NP_001023851.1¹

ENSEMBL Gene Tree for SCRIB (if available)
TreeFam Gene Tree for SCRIB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SCRIB gene

LRRC7² LRRC2² ERBB2IP² MFHAS1² LRRC18² LRRC30² LRRC1² PIDD²

LRRIQ4² SHOC2² LRRD1² LRRC10B² LRRC39² LRRC40² LRRC10²

18/20 SIMAP similar genes for SCRIB using alignment to 4 protein entries: SCRIB_HUMAN (see all proteins) (see all similar genes):

LRRC1 LRRC7 SYNJ2BP LRRC8B pp6170 DLG4

ARHGAP23 TAX1BP3 FRMPD2 MAGI1 MPDZ LRIG3

LRRC57 LRRD1 TJP2 DLG2 PDLIM7 LRRC28

SCRIB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79403624^1,2	F,	--	140126033(+)	`GGGCAG/AGAAGG`	2	--	ds500¹		1		WA	118
rs28473203^1,2	C,F,H,	--	140126264(+)	`AGGGTG/AGTGCT`	2	--	ut3¹ ese³		6		NS NA	550
rs111525001^1,2		--	140128575(+)	`GAGAGC/GGGGGT`	2	--	int¹		1		CSA	1
rs11993154^1,2	C,F,H,	--	140129755(+)	`CTCTAA/CGGGGA`	2	--	int¹ trp³		15		NS NA WA	1886
rs34691721^1,2	C,F,	--	140130821(+)	`ACCGCG/ATGGCT`	2	--	int¹		7		NA CSA	309
rs10090912^1,2	C,F,A,H,	--	140131229(+)	`GGGGGC/GGTCTA`	2	--	int¹		5		NS EA WA	536
rs58835571^1,2	C,	--	140131474(+)	`GGACAC/TAGGCA`	2	--	int¹		2		WA	120
rs115416870^1,2	C,F,	--	140131491(+)	`ACCGCC/TCTCAT`	2	--	int¹		1		WA	118
rs56986583^1,2	F,	--	140131591(+)	`AAATGG/CTAAGT`	2	--	int¹		1		WA	118
rs56208110^1,2	C,	--	140131596(+)	`GTAAGG/TAAGGG`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SCRIB (144873090 - 144897549 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCRIB: --
Human Gene Mutation Database (HGMD): SCRIB

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SCRIB for disorders About GeneDecksing

OMIM gene information: 607733 OMIM disorders: --

UniProtKB/Swiss-Prot: SCRIB_HUMAN, Q14160

Defects in SCRIB are a cause of neural tube defects (NTD) [MIM:182940]. NTD are congenital malformations of

the central nervous system and adjacent structures related to defective neural tube closure during the first trimester

of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include

anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal

region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components

19 diseases for SCRIB: About MalaCards

tick-borne encephalitis human t-cell leukemia virus type 1 scrub typhus adenomatous polyposis coli

avian influenza typhus strabismus encephalitis

polyposis t-cell leukemia influenza endometrial cancer

leukemia breast cancer prostatitis neuronitis

carcinoma craniorachischisis neural tube defect

1 Novoseek disease relationship for SCRIB gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	4	16137684 (2), 15649318 (2), 17509663 (1)

Human Genome Epidemiology (HuGE) Navigator: SCRIB (1 document)

Export disorders for SCRIB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SCRIB gene, integrated from 9 sources (see all 70):
(articles sorted by number of sources associating them with SCRIB)

Utopia: connect your pdf to the dynamic
world of online information

Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. (PubMed id 11027293)^{1, 2, 3} Nakagawa S. and Huibregtse J.M. (2000)
The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus. (PubMed id 15649318)^{1, 2, 9} Petit M.M.R....Van de Ven W.J.M. (2005)
hScrib is a functional homologue of the Drosophila tu mour suppressor Scribble. (PubMed id 14681682)^{1, 3, 9} Dow L.E....Humbert P.O. (2003)
The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins. (PubMed id 16137684)^{1, 2, 9} Petit M.M.R....Van de Ven W.J.M. (2005)
Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1- ARF6 pathway. (PubMed id 15775968)^{1, 2, 9} Lahuna O.... Misrahi M. (2005)
Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis. (PubMed id 22095531)^{1, 2} Robinson A.... Stanier P. (2012)
MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. (PubMed id 19555689)^{1, 2} Arnaud C....Lecine P. (2009)
Scrib regulates PAK activity during the cell migration process. (PubMed id 18716323)^{1, 2} Nola S.... Santoni M.-J. (2008)
Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling. (PubMed id 18641685)^{1, 2} Dow L.E....Humbert P.O. (2008)
Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling. (PubMed id 18042258)^{1, 2} Werme K....Johansson M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23513	HGNC: 30377	AceView: SCRIB	Ensembl:ENSG00000180900	euGenes: HUgn23513
ECgene: SCRIB	H-InvDB: SCRIB

(According to HUGE)
About This Section

HUGE: KIAA0147

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SCRIB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SCRIB	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SCRIB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SCRIB gene:
Search GeneIP for patents involving SCRIB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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scribbled homolog (Drosophila)

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scribbled homolog (Drosophila)

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