Aliases for SCRIB Gene
External Ids for SCRIB Gene
Previous GeneCards Identifiers for SCRIB Gene
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for SCRIB Gene
SCRIB (Scribbled Planar Cell Polarity Protein) is a Protein Coding gene. Diseases associated with SCRIB include Neural Tube Defects and Tick-Borne Encephalitis. Among its related pathways are PI3K-Akt signaling pathway and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is LRRC7.
UniProtKB/Swiss-Prot for SCRIB Gene
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.