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Aliases for SCRIB Gene

Aliases for SCRIB Gene

  • Scribbled Planar Cell Polarity Protein 2 3
  • SCRB1 3 4 6
  • KIAA0147 4 6
  • Vartul 3 4
  • CRIB1 3 4
  • Scribbled Homolog (Drosophila) 2
  • Protein Scribble Homolog 3
  • Scribbled Homolog 3
  • Protein LAP4 4
  • Scribble 4
  • SCRIB1 3
  • HScrib 4
  • LAP4 4

External Ids for SCRIB Gene

Previous GeneCards Identifiers for SCRIB Gene

  • GC08U990087
  • GC08M145136
  • GC08M144648
  • GC08M144979
  • GC08M144945
  • GC08M144874
  • GC08M140127

Summaries for SCRIB Gene

Entrez Gene Summary for SCRIB Gene

  • This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for SCRIB Gene

SCRIB (Scribbled Planar Cell Polarity Protein) is a Protein Coding gene. Diseases associated with SCRIB include craniorachischisis and neural tube defects. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. An important paralog of this gene is MFHAS1.

UniProtKB/Swiss-Prot for SCRIB Gene

  • Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.

Gene Wiki entry for SCRIB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRIB Gene

Genomics for SCRIB Gene

Regulatory Elements for SCRIB Gene

Genomic Location for SCRIB Gene

Start:
143,790,920 bp from pter
End:
143,815,379 bp from pter
Size:
24,460 bases
Orientation:
Minus strand

Genomic View for SCRIB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCRIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRIB Gene

Proteins for SCRIB Gene

  • Protein details for SCRIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14160-SCRIB_HUMAN
    Recommended name:
    Protein scribble homolog
    Protein Accession:
    Q14160
    Secondary Accessions:
    • Q6P496
    • Q7Z5D1
    • Q8WWV8
    • Q96C69
    • Q96GG1

    Protein attributes for SCRIB Gene

    Size:
    1630 amino acids
    Molecular mass:
    174885 Da
    Quaternary structure:
    • Interacts (via PDZ domains) with VANGL2. Interacts with CTNNB1 and MAPK12 (By similarity). Interacts with UBE3A and HPV E6. Interacts with PAK1 and PAK2. Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7. Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct. Interacts (via PDZ domains) with TJP2. Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells. Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function. Interacts (via PDZ domains 1 and 3) with MCC. Interacts (via fourth PDZ domain) with tick-borne encephalitis virus NS5 protein; this interaction inhibits SCRIB and downstream STAT1 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway.

    Three dimensional structures from OCA and Proteopedia for SCRIB Gene

    Alternative splice isoforms for SCRIB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCRIB Gene

Proteomics data for SCRIB Gene at MOPED

Post-translational modifications for SCRIB Gene

  • Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded.
  • Ubiquitination at Lys53, Lys63, Lys164, Lys266, and Lys272
  • Modification sites at PhosphoSitePlus

Other Protein References for SCRIB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SCRIB (Scribble)

No data available for DME Specific Peptides for SCRIB Gene

Domains for SCRIB Gene

Protein Domains for SCRIB Gene

Suggested Antigen Peptide Sequences for SCRIB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14160

UniProtKB/Swiss-Prot:

SCRIB_HUMAN :
  • Q14160
Domain:
  • Contains 4 PDZ (DHR) domains.
Family:
  • Belongs to the LAP (LRR and PDZ) protein family.
Similarity:
  • Contains 16 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SCRIB: view

No data available for Gene Families for SCRIB Gene

Function for SCRIB Gene

Molecular function for SCRIB Gene

UniProtKB/Swiss-Prot Function:
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.

Gene Ontology (GO) - Molecular Function for SCRIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15182672
genes like me logo Genes that share ontologies with SCRIB: view
genes like me logo Genes that share phenotypes with SCRIB: view

Animal Models for SCRIB Gene

MGI Knock Outs for SCRIB:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SCRIB Gene

Localization for SCRIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRIB Gene

Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCRIB Gene COMPARTMENTS Subcellular localization image for SCRIB gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for SCRIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm --
GO:0005886 colocalizes_with plasma membrane IDA 16611247
GO:0005911 cell-cell junction IDA 15649318
GO:0005913 cell-cell adherens junction IDA 16965391
genes like me logo Genes that share ontologies with SCRIB: view

Pathways for SCRIB Gene

genes like me logo Genes that share pathways with SCRIB: view

Pathways by source for SCRIB Gene

3 Cell Signaling Technology pathways for SCRIB Gene
1 BioSystems pathway for SCRIB Gene

Gene Ontology (GO) - Biological Process for SCRIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IMP 22095531
GO:0001921 positive regulation of receptor recycling IMP 15775968
GO:0002093 auditory receptor cell morphogenesis --
GO:0008105 asymmetric protein localization IEA --
GO:0008283 cell proliferation IDA 16965391
genes like me logo Genes that share ontologies with SCRIB: view

Transcripts for SCRIB Gene

Unigene Clusters for SCRIB Gene

Scribbled planar cell polarity protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCRIB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRIB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - - - -
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17: - -

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35a · 35b · 35c · 35d ^ 36 ^ 37 ^ 38 ^
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:

ExUns: 39 ^ 40a · 40b · 40c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for SCRIB Gene

GeneLoc Exon Structure for
SCRIB
ECgene alternative splicing isoforms for
SCRIB

Expression for SCRIB Gene

mRNA expression in normal human tissues for SCRIB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SCRIB Gene

This gene is overexpressed in Pancreas (12.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCRIB Gene

SOURCE GeneReport for Unigene cluster for SCRIB Gene Hs.436329

mRNA Expression by UniProt/SwissProt for SCRIB Gene

Q14160-SCRIB_HUMAN
Tissue specificity: Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
genes like me logo Genes that share expressions with SCRIB: view

Expression partners for SCRIB Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SCRIB Gene

Orthologs for SCRIB Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRIB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCRIB 35
  • 83.9 (n)
  • 86.8 (a)
SCRIB 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCRIB 35
  • 84.39 (n)
  • 86.5 (a)
SCRIB 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scrib 35
  • 81.85 (n)
  • 86.71 (a)
Scrib 16
Scrib 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCRIB 35
  • 99.01 (n)
  • 99.09 (a)
SCRIB 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scrib 35
  • 81.57 (n)
  • 87.11 (a)
oppossum
(Monodelphis domestica)
Mammalia SCRIB 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCRIB 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCRIB 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scrib 35
  • 70.7 (n)
  • 74 (a)
zebrafish
(Danio rerio)
Actinopterygii scrib 35
  • 65.31 (n)
  • 66.38 (a)
scrib 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta scrib 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-413 37
  • 45 (a)
let-413 35
  • 46.86 (n)
  • 42.7 (a)
let-413 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7054 36
  • 42 (a)
OneToMany
Species with no ortholog for SCRIB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCRIB Gene

ENSEMBL:
Gene Tree for SCRIB (if available)
TreeFam:
Gene Tree for SCRIB (if available)

Paralogs for SCRIB Gene

genes like me logo Genes that share paralogs with SCRIB: view

Variants for SCRIB Gene

Sequence variations from dbSNP and Humsavar for SCRIB Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1135293 -- 143,792,037(-) CTGGC(C/T)GAGGC reference, synonymous-codon
rs4874099 -- 143,793,365(+) GCGGC(A/G)GGGGC intron-variant
rs4874100 -- 143,800,253(+) AGGAC(C/T)TCAGA intron-variant
rs4874101 -- 143,801,917(+) GACCC(A/G)GCCAG intron-variant
rs4874102 -- 143,802,631(+) TGCAC(A/G)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCRIB Gene

Variant ID Type Subtype PubMed ID
dgv7935n71 CNV Loss 21882294
dgv7938n71 CNV Loss 21882294
dgv7939n71 CNV Loss 21882294
dgv7940n71 CNV Loss 21882294
nsv891751 CNV Loss 21882294
dgv7943n71 CNV Loss 21882294
nsv6442 CNV Loss 18451855
nsv891766 CNV Loss 21882294
dgv7944n71 CNV Loss 21882294
esv2738038 CNV Deletion 23290073
nsv398483 CNV Insertion 16902084
dgv7945n71 CNV Loss 21882294
dgv7946n71 CNV Loss 21882294
nsv466009 CNV Loss 19166990

Relevant External Links for SCRIB Gene

HapMap Linkage Disequilibrium report
SCRIB
Human Gene Mutation Database (HGMD)
SCRIB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRIB Gene

Disorders for SCRIB Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SCRIB Gene in MalaCards »

(4) Diseases for SCRIB Gene including...

UniProtKB/Swiss-Prot

SCRIB_HUMAN
  • Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. {ECO:0000269 PubMed:22095531}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) Novoseek inferred disease relationships for SCRIB Gene

Disease -log(P) Hits PubMed IDs
tumors 0 5

Relevant External Links for SCRIB

Human Genome Epidemiology (HuGE) Navigator
SCRIB
genes like me logo Genes that share disorders with SCRIB: view

No data available for OMIM , University of Copenhagen DISEASES and Genatlas for SCRIB Gene

Publications for SCRIB Gene

  1. hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. (PMID: 14681682) Dow L.E. … Humbert P.O. (Oncogene 2003) 2 3 23
  2. The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus. (PMID: 15649318) Petit M.M.R. … Van de Ven W.J.M. (BMC Cell Biol. 2005) 3 4 23
  3. Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1- ARF6 pathway. (PMID: 15775968) Lahuna O. … Misrahi M. (EMBO J. 2005) 3 4 23
  4. The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins. (PMID: 16137684) Petit M.M.R. … Van de Ven W.J.M. (FEBS Lett. 2005) 3 4 23
  5. Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. (PMID: 11027293) Nakagawa S. … Huibregtse J.M. (Mol. Cell. Biol. 2000) 2 3 4

Products for SCRIB Gene

  • Addgene plasmids for SCRIB

Sources for SCRIB Gene

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