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SCRG1 Gene

protein-coding   GIFtS: 49
GCID: GC04M174309

Stimulator Of Chondrogenesis 1

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  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Stimulator Of Chondrogenesis 11 2     Scrapie Responsive Protein 12
Scrapie Responsive Gene 11 2     Scrapie-Responsive Protein 12
Scrapie-Responsive Gene 1 Protein2 3     ScRG-13
SCRG-12     

External Ids:    HGNC: 170361   Entrez Gene: 113412   Ensembl: ENSG000001641067   OMIM: 6031635   UniProtKB: O757113   

Export aliases for SCRG1 gene to outside databases

Previous GC identifers: GC04M175229 GC04M174847 GC04M175005 GC04M174684 GC04M174545 GC04M170057


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCRG1 Gene:
Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform
encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive
protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SCRG1 Gene:
SCRG1 (stimulator of chondrogenesis 1) is a protein-coding gene. Diseases associated with SCRG1 include scrapie, and tonsillitis.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCRG1 gene promoter:
         TBP   AML1a   FOXD3   STAT5A   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   GATA-2   HEN1   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCRG1 promoter sequence
   Search Chromatin IP Primers for SCRG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCRG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.1   Ensembl cytogenetic band:  4q34.1   HGNC cytogenetic band: 4q34.1

SCRG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCRG1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M174309:  view genomic region     (about GC identifiers)

Start:
174,305,852 bp from pter      End:
174,327,531 bp from pter
Size:
21,680 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SCRG1_HUMAN, O75711 (See protein sequence)
Recommended Name: Scrapie-responsive protein 1 precursor  
Size: 98 amino acids; 11081 Da

Explore the universe of human proteins at neXtProt for SCRG1: NX_O75711

Explore proteomics data for SCRG1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn72

  • See SCRG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009212.1  
    ENSEMBL proteins: 
     ENSP00000296506   ENSP00000425404  

    SCRG1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for SCRG1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028063 SCRG1

    Graphical View of Domain Structure for InterPro Entry O75711

    ProtoNet protein and cluster: O75711

    UniProtKB/Swiss-Prot: SCRG1_HUMAN, O75711
    Similarity: Belongs to the SCRG1 family


    SCRG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 MGI phenotypic allele for Scrg1 (no phenotypes)

    SCRG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Scrg1tm1Lex for SCRG1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCRG1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCRG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCRG1

    miRNA
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    miRTarBase miRNAs that target SCRG1:
    hsa-mir-335-5p (MIRT016912)

    Block miRNA regulation of human, mouse, rat SCRG1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SCRG1:
    hsa-miR-183* hsa-miR-92a hsa-miR-363 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidSCRG1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SCRG1

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    GenScript: all cDNA clones in your preferred vector: SCRG1 (NM_007281)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCRG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCRG1

    Cell Line
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    ESI BIO PureStem Progenitor for SCRG1: 
    PureStem 4D20.8, NCr-fac Progenitor
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCRG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCRG1_HUMAN, O75711: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    golgi apparatus2
    vacuole2
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS9660755

    SCRG1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCRG1
    Interactions:

        Search GeneGlobe Interaction Network for SCRG1

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development TAS9660755

    SCRG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCRG1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SCRG1 gene: 
    NM_007281.2  

    Unigene Cluster for SCRG1:

    Stimulator of chondrogenesis 1
    Hs.7122  [show with all ESTs]
    Unigene Representative Sequence: BM548320
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296506(uc003ite.3) ENST00000512188(uc003itf.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SCRG1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SCRG1:
    hsa-miR-183* hsa-miR-92a hsa-miR-363 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidSCRG1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SCRG1
    Predesigned siRNA for gene silencing in human, mouse, rat SCRG1
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    GenScript: all cDNA clones in your preferred vector: SCRG1 (NM_007281)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCRG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCRG1
    Primer
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    OriGene qPCR primer pairs and template standards for SCRG1
    OriGene qSTAR qPCR primer pairs in human, mouse for SCRG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCRG1
      QuantiTect SYBR Green Assays in human, mouse, rat SCRG1
      QuantiFast Probe-based Assays in human, mouse, rat SCRG1

    Additional mRNA sequence: 

    AJ224677.1 AK312146.1 AY359040.1 BC017583.2 CR542142.1 

    9 DOTS entries:

    DT.216553  DT.121275342  DT.40131087  DT.97842749  DT.101972998  DT.121275353  DT.439675  DT.95145060 
    DT.95124060 

    Selected AceView cDNA sequences (see all 118):

    AA774444 AA401420 AI129876 AI588970 BE218367 AI341750 CA412616 AA400285 
    AA977656 AI431623 BQ180896 BQ574326 CR542142 AI718370 CB152765 D79872 
    AI005196 AI018515 AV709002 AI129258 AA127018 BF223410 AI129874 AI094019 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCRG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCTGGAG
    SCRG1 Expression
    About this image


    SCRG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 14 entries
             Bone Marrow
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             N2/LSB/S/F8-induced cells
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             XY Germ Cells Testis Cord
             Seminiferous Tubules
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
    SCRG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCRG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7122

    UniProtKB/Swiss-Prot: SCRG1_HUMAN, O75711
    Tissue specificity: Expressed abundantly in the central nervous system of adult, but not at all in fetal brain.
    High levels of SCRG1 transcripts are also observed in testis and aorta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCRG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SCRG1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scrg11 , 5 scrapie responsive gene 11, 5 85.22(n)1
    83.51(a)1
      8 (29.80 cM)5
    202841  NM_009136.31  NP_033162.11 
     574559235 
    chicken
    (Gallus gallus)
    Aves SCRG11 stimulator of chondrogenesis 1 67.38(n)
    62.77(a)
      422563  XM_420523.4  XP_420523.2 
    lizard
    (Anolis carolinensis)
    Reptilia SCRG16
    stimulator of chondrogenesis 1
    68(a)
    1 ↔ 1
    3(144484779-144487267)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia scrg11 stimulator of chondrogenesis 1 69.23(n)
    70.33(a)
      100489105  XM_002933326.2  XP_002933372.2 


    ENSEMBL Gene Tree for SCRG1 (if available)
    TreeFam Gene Tree for SCRG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCRG1 (see all 252)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1149890871,2
    C,F--174308823(+) AGCATA/GCATAA 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1830488911,2
    --174308884(+) TTCGAG/TACAGG 1 -- int10--------
    rs1868525741,2
    --174309024(+) TTTTTA/GATTTT 1 -- int10--------
    rs117238711,2
    C,F,A,H--174309136(+) TTCTTC/TCAATA 1 -- int125Minor allele frequency- T:0.11NS EA NA WA CSA 2258
    rs1129864781,2
    C,F--174309142(+) CAATAT/CGTGGT 1 -- int14Minor allele frequency- C:0.09CSA WA 124
    rs1410081201,2
    C--174309210(+) TCTTCA/CTCTGG 1 -- int10--------
    rs745610861,2
    C,F--174309457(+) GGAAAT/CCAGGA 1 -- ut311Minor allele frequency- C:0.09WA 118
    rs1497302921,2
    C--174309463(+) CAGGAA/GTGGTG 1 -- ut310--------
    rs1456107781,2
    C--174309591(+) CTAAGA/GTATTA 1 -- int10--------
    rs1135452721,2
    F--174309675(+) AAAATG/ATAAAG 1 -- int12Minor allele frequency- A:0.10CSA WA 120

    HapMap Linkage Disequilibrium report for SCRG1 (174305852 - 174327531 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SCRG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv259497OTHER Complex20981092
    esv259750OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCRG1
    DNA2.0 Custom Variant and Variant Library Synthesis for SCRG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603163    OMIM disorders: --

    7 diseases for SCRG1:    
    About MalaCards
    scrapie    tonsillitis    periodontitis    cerebritis
    neuronitis    thyroiditis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for SCRG1:
    Scrapie

    SCRG1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SCRG1

    Export disorders for SCRG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCRG1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SCRG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human analogue of a scrapie-responsive gene. (PubMed id 9660755)1, 2, 3, 9 Dron M.... Tovey M.G. (J. Biol. Chem. 1998)
    2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. (PubMed id 9516475)1, 3 Dandoy-Dron F....Dron M. (J. Biol. Chem. 1998)
    5. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PubMed id 17903298)4 Meigs J.B....Dupuis J. (BMC Med. Genet. 2007)
    6. A predominantly articular cartilage-associated gene, SCRG1, is induced by glucocorticoid and stimulates chondrogenesis in vitro. (PubMed id 16188469)1 Ochi K....Tuan R.S. (Osteoarthr. Cartil. 2006)
    7. Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid. (PubMed id 16199891)1 Hu Y....Holtzman D.M. (amp 2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures. (PubMed id 11087671)9 Dron M....Dandoy-Dron F. (Genomics 2000)
    10. Comprehensive gene expression analysis in human periodontal ligaments of the mandibular third molars performing vertical movement and the maxillary second premolars with occlusal contact. (PubMed id 18199074)9 Suda N. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11341 HGNC: 17036 AceView: SCRG1 Ensembl:ENSG00000164106 euGenes: HUgn11341
    ECgene: SCRG1 H-InvDB: SCRG1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCRG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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