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Aliases for SCRG1 Gene

Aliases for SCRG1 Gene

  • Stimulator Of Chondrogenesis 1 2 3
  • Scrapie-Responsive Gene 1 Protein 3 4
  • Scrapie Responsive Gene 1 2 3
  • SCRG-1 3 4
  • Scrapie Responsive Protein 1 3

External Ids for SCRG1 Gene

Previous GeneCards Identifiers for SCRG1 Gene

  • GC04M175229
  • GC04M174847
  • GC04M175005
  • GC04M174684
  • GC04M174545
  • GC04M174309
  • GC04M170057

Summaries for SCRG1 Gene

Entrez Gene Summary for SCRG1 Gene

  • Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCRG1 Gene

SCRG1 (Stimulator Of Chondrogenesis 1) is a Protein Coding gene. Diseases associated with SCRG1 include scrapie.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRG1 Gene

Genomics for SCRG1 Gene

Regulatory Elements for SCRG1 Gene

Genomic Location for SCRG1 Gene

Chromosome:
4
Start:
173,384,701 bp from pter
End:
173,476,691 bp from pter
Size:
91,991 bases
Orientation:
Minus strand

Genomic View for SCRG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SCRG1 Gene

Proteins for SCRG1 Gene

  • Protein details for SCRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75711-SCRG1_HUMAN
    Recommended name:
    Scrapie-responsive protein 1
    Protein Accession:
    O75711

    Protein attributes for SCRG1 Gene

    Size:
    98 amino acids
    Molecular mass:
    11081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCRG1 Gene

Proteomics data for SCRG1 Gene at MOPED

Post-translational modifications for SCRG1 Gene

  • Glycosylation at Asn 72
  • Modification sites at PhosphoSitePlus

Other Protein References for SCRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCRG1 Gene

Domains & Families for SCRG1 Gene

Protein Domains for SCRG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCRG1 Gene

Graphical View of Domain Structure for InterPro Entry

O75711

UniProtKB/Swiss-Prot:

SCRG1_HUMAN :
  • Belongs to the SCRG1 family.
Family:
  • Belongs to the SCRG1 family.
genes like me logo Genes that share domains with SCRG1: view

No data available for Gene Families for SCRG1 Gene

Function for SCRG1 Gene

Gene Ontology (GO) - Molecular Function for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SCRG1: view
genes like me logo Genes that share phenotypes with SCRG1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCRG1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRG1 Gene

Localization for SCRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCRG1 Gene COMPARTMENTS Subcellular localization image for SCRG1 gene
Compartment Confidence
extracellular 4
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 9660755
genes like me logo Genes that share ontologies with SCRG1: view

Pathways & Interactions for SCRG1 Gene

SuperPathways for SCRG1 Gene

No Data Available

Interacting Proteins for SCRG1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296506%0d%0a9606.ENSP00000309052%0d%0a
Selected Interacting proteins: O75711-SCRG1_HUMAN ENSP00000296506 for SCRG1 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9660755
genes like me logo Genes that share ontologies with SCRG1: view

No data available for Pathways by source and SIGNOR curated interactions for SCRG1 Gene

Drugs & Compounds for SCRG1 Gene

No Compound Related Data Available

Transcripts for SCRG1 Gene

mRNA/cDNA for SCRG1 Gene

Unigene Clusters for SCRG1 Gene

Stimulator of chondrogenesis 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCRG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRG1 Gene

No ASD Table

Relevant External Links for SCRG1 Gene

GeneLoc Exon Structure for
SCRG1
ECgene alternative splicing isoforms for
SCRG1

Expression for SCRG1 Gene

mRNA expression in normal human tissues for SCRG1 Gene

mRNA differential expression in normal tissues according to GTEx for SCRG1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.2).

Protein differential expression in normal tissues from HIPED for SCRG1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCRG1 Gene



SOURCE GeneReport for Unigene cluster for SCRG1 Gene Hs.7122

mRNA Expression by UniProt/SwissProt for SCRG1 Gene

O75711-SCRG1_HUMAN
Tissue specificity: Expressed abundantly in the central nervous system of adult, but not at all in fetal brain. High levels of SCRG1 transcripts are also observed in testis and aorta
genes like me logo Genes that share expression patterns with SCRG1: view

Protein tissue co-expression partners for SCRG1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCRG1 Gene

Orthologs for SCRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCRG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCRG1 35
  • 92.18 (n)
  • 88.78 (a)
SCRG1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scrg1 35
  • 85.22 (n)
  • 83.51 (a)
Scrg1 16
Scrg1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCRG1 35
  • 99.32 (n)
  • 100 (a)
SCRG1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scrg1 35
  • 83.85 (n)
  • 82.47 (a)
dog
(Canis familiaris)
Mammalia SCRG1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCRG1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCRG1 36
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCRG1 35
  • 67.38 (n)
  • 62.77 (a)
SCRG1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCRG1 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scrg1 35
  • 69.23 (n)
  • 70.33 (a)
Species with no ortholog for SCRG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCRG1 Gene

ENSEMBL:
Gene Tree for SCRG1 (if available)
TreeFam:
Gene Tree for SCRG1 (if available)

Paralogs for SCRG1 Gene

No data available for Paralogs for SCRG1 Gene

Variants for SCRG1 Gene

Sequence variations from dbSNP and Humsavar for SCRG1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_020329 -

Structural Variations from Database of Genomic Variants (DGV) for SCRG1 Gene

Variant ID Type Subtype PubMed ID
esv259497 OTHER Complex 20981092
esv259750 OTHER Complex 20981092

Variation tolerance for SCRG1 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCRG1 Gene

HapMap Linkage Disequilibrium report
SCRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRG1 Gene

Disorders for SCRG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCRG1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
scrapie
- elite association
Search SCRG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCRG1

Genetic Association Database (GAD)
SCRG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCRG1
genes like me logo Genes that share disorders with SCRG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCRG1 Gene

Publications for SCRG1 Gene

  1. Characterization of the human analogue of a scrapie-responsive gene. (PMID: 9660755) Dron M. … Tovey M.G. (J. Biol. Chem. 1998) 2 23 67
  2. Comprehensive gene expression analysis in human periodontal ligaments of the mandibular third molars performing vertical movement and the maxillary second premolars with occlusal contact. (PMID: 18199074) Suda N. (Orthod Craniofac Res 2008) 23 67
  3. Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures. (PMID: 11087671) Dron M. … Dandoy-Dron F. (Genomics 2000) 23 67
  4. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. (PMID: 9516475) Dandoy-Dron F. … Dron M. (J. Biol. Chem. 1998) 2 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for SCRG1 Gene

Sources for SCRG1 Gene

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