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Aliases for SCRG1 Gene

Aliases for SCRG1 Gene

  • Stimulator Of Chondrogenesis 1 2 3
  • Scrapie-Responsive Gene 1 Protein 3 4
  • Scrapie Responsive Gene 1 2 3
  • SCRG-1 3 4
  • Scrapie Responsive Protein 1 3
  • Scrapie-Responsive Protein 1 3

External Ids for SCRG1 Gene

Previous GeneCards Identifiers for SCRG1 Gene

  • GC04M175229
  • GC04M174847
  • GC04M175005
  • GC04M174684
  • GC04M174545
  • GC04M174309
  • GC04M170057

Summaries for SCRG1 Gene

Entrez Gene Summary for SCRG1 Gene

  • Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCRG1 Gene

SCRG1 (Stimulator Of Chondrogenesis 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRG1 Gene

Genomics for SCRG1 Gene

Regulatory Elements for SCRG1 Gene

Genomic Location for SCRG1 Gene

173,384,701 bp from pter
173,476,214 bp from pter
91,514 bases
Minus strand

Genomic View for SCRG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRG1 Gene

Proteins for SCRG1 Gene

  • Protein details for SCRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Scrapie-responsive protein 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SCRG1 Gene

    98 amino acids
    Molecular mass:
    11081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCRG1 Gene

Proteomics data for SCRG1 Gene at MOPED

Post-translational modifications for SCRG1 Gene

  • Glycosylation at Asn72
  • Modification sites at PhosphoSitePlus

Other Protein References for SCRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCRG1 Gene

Domains for SCRG1 Gene

Protein Domains for SCRG1 Gene


Suggested Antigen Peptide Sequences for SCRG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • O75711
  • Belongs to the SCRG1 family.
genes like me logo Genes that share domains with SCRG1: view

No data available for Gene Families for SCRG1 Gene

Function for SCRG1 Gene

Gene Ontology (GO) - Molecular Function for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SCRG1: view

Animal Model Products

miRNA for SCRG1 Gene

miRTarBase miRNAs that target SCRG1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCRG1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCRG1 Gene

Localization for SCRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRG1 Gene


Subcellular locations from

Jensen Localization Image for SCRG1 Gene COMPARTMENTS Subcellular localization image for SCRG1 gene
Compartment Confidence
extracellular 4
golgi apparatus 2
vacuole 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 9660755
genes like me logo Genes that share ontologies with SCRG1: view

Pathways for SCRG1 Gene

SuperPathways for SCRG1 Gene

No Data Available

Interacting Proteins for SCRG1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000296506 O75711-SCRG1_HUMAN for SCRG1 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9660755
genes like me logo Genes that share ontologies with SCRG1: view

No data available for Pathways by source for SCRG1 Gene

Transcripts for SCRG1 Gene

mRNA/cDNA for SCRG1 Gene

Unigene Clusters for SCRG1 Gene

Stimulator of chondrogenesis 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCRG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRG1 Gene

No ASD Table

Relevant External Links for SCRG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCRG1 Gene

mRNA expression in normal human tissues for SCRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCRG1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.2).

Protein differential expression in normal tissues for SCRG1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCRG1 Gene

SOURCE GeneReport for Unigene cluster for SCRG1 Gene Hs.7122

mRNA Expression by UniProt/SwissProt for SCRG1 Gene

Tissue specificity: Expressed abundantly in the central nervous system of adult, but not at all in fetal brain. High levels of SCRG1 transcripts are also observed in testis and aorta
genes like me logo Genes that share expressions with SCRG1: view

Expression partners for SCRG1 Gene

In Situ Assay Products

Orthologs for SCRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCRG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCRG1 35
  • 92.18 (n)
  • 88.78 (a)
SCRG1 36
  • 89 (a)
(Mus musculus)
Mammalia Scrg1 35
  • 85.22 (n)
  • 83.51 (a)
Scrg1 16
Scrg1 36
  • 82 (a)
(Pan troglodytes)
Mammalia SCRG1 35
  • 99.32 (n)
  • 100 (a)
SCRG1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Scrg1 35
  • 83.85 (n)
  • 82.47 (a)
(Canis familiaris)
Mammalia SCRG1 36
  • 88 (a)
(Monodelphis domestica)
Mammalia SCRG1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SCRG1 36
  • 31 (a)
(Gallus gallus)
Aves SCRG1 35
  • 67.38 (n)
  • 62.77 (a)
SCRG1 36
  • 59 (a)
(Anolis carolinensis)
Reptilia SCRG1 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scrg1 35
  • 69.23 (n)
  • 70.33 (a)
Species with no ortholog for SCRG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCRG1 Gene

Gene Tree for SCRG1 (if available)
Gene Tree for SCRG1 (if available)

Paralogs for SCRG1 Gene

No data available for Paralogs for SCRG1 Gene

Variants for SCRG1 Gene

Sequence variations from dbSNP and Humsavar for SCRG1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs880960 -- 173,441,258(-) TAAAA(C/T)TTTGT intron-variant
rs880961 -- 173,441,101(-) TGCCC(A/T)CATCT intron-variant
rs880962 -- 173,441,050(-) CACCC(C/T)CAAAT intron-variant
rs1319302 -- 173,474,490(+) AGAGT(C/G)AGAAA intron-variant
rs1348225 -- 173,429,613(+) GAACC(A/T)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCRG1 Gene

Variant ID Type Subtype PubMed ID
esv259497 OTHER Complex 20981092
esv259750 OTHER Complex 20981092

Relevant External Links for SCRG1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRG1 Gene

Disorders for SCRG1 Gene

(1) University of Copenhagen DISEASES for SCRG1 Gene

Relevant External Links for SCRG1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with SCRG1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SCRG1 Gene

Publications for SCRG1 Gene

  1. Characterization of the human analogue of a scrapie-responsive gene. (PMID: 9660755) Dron M. … Tovey M.G. (J. Biol. Chem. 1998) 2 3 4 23
  2. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. (PMID: 9516475) Dandoy-Dron F. … Dron M. (J. Biol. Chem. 1998) 2 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. A predominantly articular cartilage-associated gene, SCRG1, is induced by glucocorticoid and stimulates chondrogenesis in vitro. (PMID: 16188469) Ochi K. … Tuan R.S. (Osteoarthr. Cartil. 2006) 3

Products for SCRG1 Gene

Sources for SCRG1 Gene

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