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Aliases for SCRG1 Gene

Aliases for SCRG1 Gene

  • Stimulator Of Chondrogenesis 1 2 3 5
  • Scrapie-Responsive Gene 1 Protein 3 4
  • Scrapie Responsive Gene 1 2 3
  • SCRG-1 3 4
  • Scrapie Responsive Protein 1 3

External Ids for SCRG1 Gene

Previous GeneCards Identifiers for SCRG1 Gene

  • GC04M175229
  • GC04M174847
  • GC04M175005
  • GC04M174684
  • GC04M174545
  • GC04M174309
  • GC04M170057

Summaries for SCRG1 Gene

Entrez Gene Summary for SCRG1 Gene

  • Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCRG1 Gene

SCRG1 (Stimulator Of Chondrogenesis 1) is a Protein Coding gene. Diseases associated with SCRG1 include Scrapie.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRG1 Gene

Genomics for SCRG1 Gene

Regulatory Elements for SCRG1 Gene

Enhancers for SCRG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCRG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCRG1 Gene

173,384,701 bp from pter
173,476,691 bp from pter
91,991 bases
Minus strand

Genomic View for SCRG1 Gene

Genes around SCRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRG1 Gene

Proteins for SCRG1 Gene

  • Protein details for SCRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Scrapie-responsive protein 1
    Protein Accession:

    Protein attributes for SCRG1 Gene

    98 amino acids
    Molecular mass:
    11081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCRG1 Gene

Proteomics data for SCRG1 Gene at MOPED

Post-translational modifications for SCRG1 Gene

  • Glycosylation at Asn 72
  • Modification sites at PhosphoSitePlus

Other Protein References for SCRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCRG1 Gene

Domains & Families for SCRG1 Gene

Protein Domains for SCRG1 Gene


Suggested Antigen Peptide Sequences for SCRG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SCRG1 family.
  • Belongs to the SCRG1 family.
genes like me logo Genes that share domains with SCRG1: view

No data available for Gene Families for SCRG1 Gene

Function for SCRG1 Gene

genes like me logo Genes that share phenotypes with SCRG1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCRG1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRG1 Gene

Localization for SCRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRG1 Gene


Subcellular locations from

Jensen Localization Image for SCRG1 Gene COMPARTMENTS Subcellular localization image for SCRG1 gene
Compartment Confidence
extracellular 5
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044306 neuron projection terminus IEA --
genes like me logo Genes that share ontologies with SCRG1: view

Pathways & Interactions for SCRG1 Gene

SuperPathways for SCRG1 Gene

No Data Available

Interacting Proteins for SCRG1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000296506 O75711-SCRG1_HUMAN for SCRG1 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SCRG1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SCRG1 Gene

Drugs & Compounds for SCRG1 Gene

No Compound Related Data Available

Transcripts for SCRG1 Gene

mRNA/cDNA for SCRG1 Gene

Unigene Clusters for SCRG1 Gene

Stimulator of chondrogenesis 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCRG1 Gene

No ASD Table

Relevant External Links for SCRG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCRG1 Gene

mRNA expression in normal human tissues for SCRG1 Gene

mRNA differential expression in normal tissues according to GTEx for SCRG1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.2).

Protein differential expression in normal tissues from HIPED for SCRG1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCRG1 Gene

SOURCE GeneReport for Unigene cluster for SCRG1 Gene Hs.7122

mRNA Expression by UniProt/SwissProt for SCRG1 Gene

Tissue specificity: Expressed abundantly in the central nervous system of adult, but not at all in fetal brain. High levels of SCRG1 transcripts are also observed in testis and aorta.
genes like me logo Genes that share expression patterns with SCRG1: view

Protein tissue co-expression partners for SCRG1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCRG1 Gene

Orthologs for SCRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCRG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCRG1 35
  • 92.18 (n)
  • 88.78 (a)
SCRG1 36
  • 89 (a)
(Mus musculus)
Mammalia Scrg1 35
  • 85.22 (n)
  • 83.51 (a)
Scrg1 16
Scrg1 36
  • 82 (a)
(Pan troglodytes)
Mammalia SCRG1 35
  • 99.32 (n)
  • 100 (a)
SCRG1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Scrg1 35
  • 83.85 (n)
  • 82.47 (a)
(Canis familiaris)
Mammalia SCRG1 36
  • 88 (a)
(Monodelphis domestica)
Mammalia SCRG1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SCRG1 36
  • 31 (a)
(Gallus gallus)
Aves SCRG1 35
  • 67.38 (n)
  • 62.77 (a)
SCRG1 36
  • 59 (a)
(Anolis carolinensis)
Reptilia SCRG1 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scrg1 35
  • 69.23 (n)
  • 70.33 (a)
Species with no ortholog for SCRG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCRG1 Gene

Gene Tree for SCRG1 (if available)
Gene Tree for SCRG1 (if available)

Paralogs for SCRG1 Gene

No data available for Paralogs for SCRG1 Gene

Variants for SCRG1 Gene

Sequence variations from dbSNP and Humsavar for SCRG1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_020329 -

Structural Variations from Database of Genomic Variants (DGV) for SCRG1 Gene

Variant ID Type Subtype PubMed ID
esv259497 OTHER Complex 20981092
esv259750 OTHER Complex 20981092

Variation tolerance for SCRG1 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SCRG1 Gene

Disorders for SCRG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCRG1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search SCRG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCRG1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SCRG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCRG1 Gene

Publications for SCRG1 Gene

  1. Characterization of the human analogue of a scrapie-responsive gene. (PMID: 9660755) Dron M. … Tovey M.G. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. (PMID: 9516475) Dandoy-Dron F. … Dron M. (J. Biol. Chem. 1998) 2 3
  3. Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells. (PMID: 24413464) Aomatsu E. … Chosa N. (Sci Rep 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Comprehensive gene expression analysis in human periodontal ligaments of the mandibular third molars performing vertical movement and the maxillary second premolars with occlusal contact. (PMID: 18199074) Suda N. (Orthod Craniofac Res 2008) 23

Products for SCRG1 Gene

Sources for SCRG1 Gene