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Aliases for SCRG1 Gene

Aliases for SCRG1 Gene

  • Stimulator Of Chondrogenesis 1 2 3 5
  • Scrapie-Responsive Gene 1 Protein 3 4
  • Scrapie Responsive Gene 1 2 3
  • SCRG-1 3 4
  • Scrapie-Responsive Protein 1 3

External Ids for SCRG1 Gene

Previous GeneCards Identifiers for SCRG1 Gene

  • GC04M175229
  • GC04M174847
  • GC04M175005
  • GC04M174684
  • GC04M174545
  • GC04M174309
  • GC04M170057

Summaries for SCRG1 Gene

Entrez Gene Summary for SCRG1 Gene

  • Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016]

GeneCards Summary for SCRG1 Gene

SCRG1 (Stimulator Of Chondrogenesis 1) is a Protein Coding gene. Diseases associated with SCRG1 include Scrapie.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRG1 Gene

Genomics for SCRG1 Gene

Regulatory Elements for SCRG1 Gene

Enhancers for SCRG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F173345 0.7 Ensembl ENCODE 17.8 +130.5 130453 1.3 PKNOX1 MTA2 ZNF266 JUND SCRT2 ZNF600 ZNF24 SPI1 TRIM28 SCRG1 GC04M173344 GC04P173358
GH04F173424 0.8 Ensembl ENCODE 12.9 +51.3 51265 1.9 SCRG1 RNU6-1096P LOC105377538 RPL5P11 GC04P173442
GH04F173366 1.2 Ensembl ENCODE 12.8 +109.0 109026 1.6 JUN CEBPB JUNB TBX21 ARID1B JUND SCRT2 HMBOX1 CREM PRDM1 HMGB2 LOC105377538 SCRG1 RNU6-1096P CEP44 FBXO8 SAP30 GC04P173358
GH04F173374 0.5 Ensembl 12.4 +102.5 102491 0.4 ZBTB33 HMGB2 LOC105377538 SCRG1 FBXO8 CEP44 LOC105377540 LOC101928383
GH04F173369 0.4 ENCODE 12.4 +105.6 105587 4.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FBXO8 CEP44 HMGB2 LOC105377538 HAND2 SCRG1 HAND2-AS1 LOC105377540 LOC101928383
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SCRG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCRG1 Gene

173,384,701 bp from pter
173,476,691 bp from pter
91,991 bases
Minus strand

Genomic View for SCRG1 Gene

Genes around SCRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRG1 Gene

Proteins for SCRG1 Gene

  • Protein details for SCRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Scrapie-responsive protein 1
    Protein Accession:

    Protein attributes for SCRG1 Gene

    98 amino acids
    Molecular mass:
    11081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCRG1 Gene

Post-translational modifications for SCRG1 Gene

  • Glycosylation at Asn 72
  • Modification sites at PhosphoSitePlus

Other Protein References for SCRG1 Gene

No data available for DME Specific Peptides for SCRG1 Gene

Domains & Families for SCRG1 Gene

Protein Domains for SCRG1 Gene


Suggested Antigen Peptide Sequences for SCRG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SCRG1 family.
  • Belongs to the SCRG1 family.
genes like me logo Genes that share domains with SCRG1: view

No data available for Gene Families for SCRG1 Gene

Function for SCRG1 Gene

Gene Ontology (GO) - Molecular Function for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SCRG1: view
genes like me logo Genes that share phenotypes with SCRG1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCRG1

Inhibitory RNA Products

Cell Line Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRG1 Gene

Localization for SCRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRG1 Gene


Subcellular locations from

Jensen Localization Image for SCRG1 Gene COMPARTMENTS Subcellular localization image for SCRG1 gene
Compartment Confidence
extracellular 5
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 9660755
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0044306 neuron projection terminus IEA --
genes like me logo Genes that share ontologies with SCRG1: view

Pathways & Interactions for SCRG1 Gene

SuperPathways for SCRG1 Gene

No Data Available

Interacting Proteins for SCRG1 Gene

Gene Ontology (GO) - Biological Process for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9660755
GO:0097168 mesenchymal stem cell proliferation IDA --
genes like me logo Genes that share ontologies with SCRG1: view

No data available for Pathways by source and SIGNOR curated interactions for SCRG1 Gene

Transcripts for SCRG1 Gene

Unigene Clusters for SCRG1 Gene

Stimulator of chondrogenesis 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRG1 Gene

No ASD Table

Relevant External Links for SCRG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCRG1 Gene

mRNA differential expression in normal tissues according to GTEx for SCRG1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.2).

Protein differential expression in normal tissues from HIPED for SCRG1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCRG1 Gene

Protein tissue co-expression partners for SCRG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCRG1 Gene:


SOURCE GeneReport for Unigene cluster for SCRG1 Gene:


mRNA Expression by UniProt/SwissProt for SCRG1 Gene:

Tissue specificity: Expressed abundantly in the central nervous system of adult, but not at all in fetal brain. High levels of SCRG1 transcripts are also observed in testis and aorta.
genes like me logo Genes that share expression patterns with SCRG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCRG1 Gene

Orthologs for SCRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCRG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCRG1 34 35
  • 99.32 (n)
(Bos Taurus)
Mammalia SCRG1 34 35
  • 92.18 (n)
(Canis familiaris)
Mammalia SCRG1 35
  • 88 (a)
(Mus musculus)
Mammalia Scrg1 34 16 35
  • 85.22 (n)
(Rattus norvegicus)
Mammalia Scrg1 34
  • 83.85 (n)
(Monodelphis domestica)
Mammalia SCRG1 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SCRG1 35
  • 31 (a)
(Gallus gallus)
Aves SCRG1 34 35
  • 67.38 (n)
(Anolis carolinensis)
Reptilia SCRG1 35
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scrg1 34
  • 69.23 (n)
Species where no ortholog for SCRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCRG1 Gene

Gene Tree for SCRG1 (if available)
Gene Tree for SCRG1 (if available)

Paralogs for SCRG1 Gene

No data available for Paralogs for SCRG1 Gene

Variants for SCRG1 Gene

Sequence variations from dbSNP and Humsavar for SCRG1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10002252 -- 173,411,464(+) GGGTC(A/G)GGGTT intron-variant, nc-transcript-variant
rs10004826 -- 173,430,284(+) TCACT(A/C)AGGTT intron-variant
rs10010027 -- 173,428,223(+) TCACA(A/C)TTTAC intron-variant
rs10011797 -- 173,444,499(+) GAATG(A/G)GTATG intron-variant
rs10012836 -- 173,502,530(+) CCTTT(C/T)TAAGC intron-variant

Variation tolerance for SCRG1 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCRG1 Gene

Disorders for SCRG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCRG1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search SCRG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCRG1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SCRG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCRG1 Gene

Publications for SCRG1 Gene

  1. Characterization of the human analogue of a scrapie-responsive gene. (PMID: 9660755) Dron M. … Tovey M.G. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. (PMID: 9516475) Dandoy-Dron F. … Dron M. (J. Biol. Chem. 1998) 2 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for SCRG1 Gene

Sources for SCRG1 Gene

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