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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SCRG1 Gene

protein-coding GIFtS: 43
GCID: GC04M174309

stimulator of chondrogenesis 1

Explore 3 diseases affiliated with
SCRG1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Stimulator Of Chondrogenesis 1¹ ²		Scrapie Responsive Protein 1²
SCRG-1¹ ²		Scrapie-Responsive Protein 1²
Scrapie-Responsive Gene 1 Protein² ³		ScRG-1³
Scrapie Responsive Gene 1²

External Ids:	HGNC: 17036¹	Entrez Gene: 11341²	Ensembl: ENSG00000164106⁷	OMIM: 603163⁵	UniProtKB: O75711³

Export aliases for SCRG1 gene to outside databases

Previous GC identifers: GC04M175229 GC04M174847 GC04M175005 GC04M174684 GC04M174545 GC04M170057

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCRG1:

Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform

encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1

may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. (provided by

RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SCRG1 gene promoter:
TBP AML1a FOXD3 STAT5A POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 GATA-2 HEN1 TFIID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCRG1 promoter sequence

Search SABiosciences Chromatin IP Primers for SCRG1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCRG1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.1 Ensembl cytogenetic band: 4q34.1 HGNC cytogenetic band: 4q34.1

SCRG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCRG1 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M174309: view genomic region (about GC identifiers)

Start:	174,309,299 bp from pter	End:	174,327,531 bp from pter
Size:	18,233 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SCRG1_HUMAN, O75711 (See protein sequence)

Recommended Name: Scrapie-responsive protein 1 precursor

Size: 98 amino acids; 11081 Da

Subcellular location: Secreted (Probable)

Explore the universe of human proteins at neXtProt for SCRG1: NX_O75711

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75711

SCRG1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_009212.1

ENSEMBL proteins:

ENSP00000296506 ENSP00000425404

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	9660755

SCRG1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: O75711

UniProtKB/Swiss-Prot: SCRG1_HUMAN, O75711

Similarity: Belongs to the SCRG1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 MGI phenotypic allele

for Scrg1 (no phenotypes)

SCRG1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Scrg1^tm1Lex for SCRG1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SCRG1

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SCRG1

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007399	nervous system development	TAS	9660755

SCRG1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SCRG1
Search CenterWatch for drugs/clinical trials and news about SCRG1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for SCRG1 gene:

NM_007281.2

Unigene Cluster for SCRG1:

Stimulator of chondrogenesis 1

Hs.7122 [show with all ESTs]

Unigene Representative Sequence: BM548320

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000296506(uc003ite.3) ENST00000512188(uc003itf.3)

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Additional cDNA sequence:

AJ224677.1 AK312146.1 AY359040.1 BC017583.2 CR542142.1

10 DOTS entries:

DT.216553 DT.121275342 DT.40131087 DT.97842749 DT.101972998 DT.121275353 DT.439675 DT.95145060

DT.101957193 DT.95124060

24/118 AceView cDNA sequences (see all 118):

AI129874 AI094019 AA393569 AI129876 AA774444 AI435359 AA444139 AV709002

AV728636 AA127018 CR542142 CA412616 AI431623 AI018515 CB152765 BQ574326

BE218367 AI005196 AI588970 AI718370 AI129258 BQ180896 AA400285 D79872

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCRG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTCTGGAG

About this image

SCRG1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Node

Atrioventricular Node Cells

Myocardium

Bone

Autopod Long Bone

Bone

Zeugopod Epiphyseal End

Bone

Zeugopod Growth Plate

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/16 LifeMap Cells (see all 16)

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

N2/LSB/S/F8-induced cells (Generation of midbra...)

Beating cell clusters (Spontaneous differen...)

HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

See SCRG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCRG1

SOURCE GeneReport for Unigene cluster: Hs.7122

UniProtKB/Swiss-Prot: SCRG1_HUMAN, O75711

Tissue specificity: Expressed abundantly in the central nervous system of adult, but not at all in fetal brain. High

levels of SCRG1 transcripts are also observed in testis and aorta

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SCRG1 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Scrg1^{1 , 5}	scrapie responsive gene 1^{1, 5}	85.42(n)¹ 84.37(a)¹		8 (29.80 cM)⁵ 20284¹ NM_009136.3¹ NP_033162.1¹ 57455923⁵
chicken (Gallus gallus)	Aves	SCRG1¹	stimulator of chondrogenesis 1	67.38(n) 62.77(a)		422563 XM_420523.3 XP_420523.2
lizard (Anolis carolinensis)	Reptilia	SCRG1⁶	--	69(a)	1 ↔ 1	3(144484806-144486276)

ENSEMBL Gene Tree for SCRG1 (if available)
TreeFam Gene Tree for SCRG1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114989087^1,2	F	--	174308823(+)	`AGCATA/GCATAA`	1	--	int¹		1		WA	118
rs183048891^1,2		--	174308884(+)	`TTCGAG/TACAGG`	1	--	int¹		0	--	--	--	--
rs186852574^1,2		--	174309024(+)	`TTTTTA/GATTTT`	1	--	int¹		0	--	--	--	--
rs11723871^1,2	C,F,A,H	--	174309136(+)	`TTCTTC/TCAATA`	1	--	int¹		25		NS EA NA WA CSA	2258
rs112986478^1,2	C,F	--	174309142(+)	`CAATAT/CGTGGT`	1	--	int¹		4		CSA WA	124
rs141008120^1,2		--	174309210(+)	`TCTTCA/CTCTGG`	1	--	int¹		0	--	--	--	--
rs74561086^1,2	C,F	--	174309457(+)	`GGAAAT/CCAGGA`	1	--	ut3¹		1		WA	118
rs149730292^1,2	C	--	174309463(+)	`CAGGAA/GTGGTG`	1	--	ut3¹		0	--	--	--	--
rs145610778^1,2	C	--	174309591(+)	`CTAAGA/GTATTA`	1	--	int¹		0	--	--	--	--
rs113545272^1,2		--	174309675(+)	`AAAATG/ATAAAG`	1	--	int¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for SCRG1 (174309299 - 174327531 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCRG1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SCRG1 for disorders           About GeneDecksing

OMIM gene information: 603163    OMIM disorders: --

3 diseases for SCRG1:    About MalaCards

scrapie periodontitis neuronitis

1 disease from the University of Copenhagen DISEASES database for SCRG1:

Scrapie

Export disorders for SCRG1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SCRG1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SCRG1)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of the human analogue of a scrapie-responsive gene. (PubMed id 9660755)^{1, 2, 3, 9} Dron M.... Tovey M.G. (1998)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. (PubMed id 9516475)^{1, 3} Dandoy-Dron F....Dron M. (1998)
A predominantly articular cartilage-associated gene, SCRG1, is induced by glucocorticoid and stimulates chondrogenesis in vitro. (PubMed id 16188469)¹ Ochi K....Tuan R.S. (2006)
Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid. (PubMed id 16199891)¹ Hu Y....Holtzman D.M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures. (PubMed id 11087671)⁹ Dron M....Dandoy-Dron F. (2000)
Comprehensive gene expression analysis in human periodontal ligaments of the mandibular third molars performing vertical movement and the maxillary second premolars with occlusal contact. (PubMed id 18199074)⁹ Suda N. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11341	HGNC: 17036	AceView: SCRG1	Ensembl:ENSG00000164106	euGenes: HUgn11341
ECgene: SCRG1	H-InvDB: SCRG1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SCRG1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SCRG1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SCRG1 gene:
Search GeneIP for patents involving SCRG1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for SCRG1
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	OriGene siRNA for SCRG1		OriGene 3'-UTR Clone for SCRG1
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	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SCRG1		OriGene Custom Protein Services for SCRG1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCRG1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCRG1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCRG1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCRG1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCRG1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCRG1

	GenScript Custom Purified and Recombinant Proteins Services for SCRG1		GenScript cDNA clones with any tag delivered in your preferred vector for SCRG1
	GenScript Custom Assay Services for SCRG1		GenScript Custom Superior Antibodies Services for SCRG1
	GenScript Custom overexpressing Cell Line Services for SCRG1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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SCRG1 Proteins, Antibodies, CLIAs, and ELISAs

Cell Line associated with SCRG1: PureStem 4D20.8, NCr-fac Progenitor

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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SCRG1

	SwitchGear 3'UTR luciferase reporter plasmids for SCRG1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCRG1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SCRG1

Sirion Biotech Customized:

	stable knockdown cell line services for SCRG1
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	design and validation of potent shRNA sequences against SCRG1
	adenovirus for potent knockdown of SCRG1
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	stable overexpressing cell line services for SCRG1
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SCRG1 gene at Home site.

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SCRG1 Gene

stimulator of chondrogenesis 1

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SCRG1 Gene

stimulator of chondrogenesis 1

Aliasesfor SCRG1 gene

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Genomic Viewsfor SCRG1 gene

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Protein Domains /Familiesfor SCRG1 gene

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