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Aliases for SCRG1 Gene

Aliases for SCRG1 Gene

  • Stimulator Of Chondrogenesis 1 2 3 5
  • Scrapie-Responsive Gene 1 Protein 3 4
  • Scrapie Responsive Gene 1 2 3
  • SCRG-1 3 4
  • Scrapie-Responsive Protein 1 3

External Ids for SCRG1 Gene

Previous GeneCards Identifiers for SCRG1 Gene

  • GC04M175229
  • GC04M174847
  • GC04M175005
  • GC04M174684
  • GC04M174545
  • GC04M174309
  • GC04M170057

Summaries for SCRG1 Gene

Entrez Gene Summary for SCRG1 Gene

  • Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016]

GeneCards Summary for SCRG1 Gene

SCRG1 (Stimulator Of Chondrogenesis 1) is a Protein Coding gene. Diseases associated with SCRG1 include Scrapie.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCRG1 Gene

Genomics for SCRG1 Gene

Regulatory Elements for SCRG1 Gene

Enhancers for SCRG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G173369 1.4 ENCODE dbSUPER 12.4 +105.6 105587 4.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 CEP44 HMGB2 ENSG00000248774 SCRG1 FBXO8 LOC105377540 LOC101928383
GH04G173263 1.3 Ensembl ENCODE dbSUPER 10.6 +212.0 211950 1.7 HDAC1 CBX3 TAL1 SIN3A FEZF1 ZKSCAN1 TCF12 POLR2A GATA2 NCOR1 SCRG1 MIR548T LOC101930370
GH04G173331 1.1 ENCODE 10.9 +142.3 142342 4.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 SCRG1 ENSG00000248774 LOC105377541
GH04G173013 1.1 Ensembl ENCODE 10.9 +462.3 462275 2.0 PKNOX1 INSM2 FEZF1 RAD21 GATA2 SCRT2 ZSCAN5C KLF7 ZNF391 FOS SCRG1 PIR59468 GC04M173056
GH04G173254 1.1 ENCODE dbSUPER 10.5 +220.0 219958 4.9 RAD21 TCF12 GATA2 ZNF143 RELB ZNF654 CEBPB ZEB2 REST TBX21 ENSG00000248774 SCRG1 MIR548T LOC101930370
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCRG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCRG1 Gene

Chromosome:
4
Start:
173,384,701 bp from pter
End:
173,476,691 bp from pter
Size:
91,991 bases
Orientation:
Minus strand

Genomic View for SCRG1 Gene

Genes around SCRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRG1 Gene

Proteins for SCRG1 Gene

  • Protein details for SCRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75711-SCRG1_HUMAN
    Recommended name:
    Scrapie-responsive protein 1
    Protein Accession:
    O75711

    Protein attributes for SCRG1 Gene

    Size:
    98 amino acids
    Molecular mass:
    11081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCRG1 Gene

Post-translational modifications for SCRG1 Gene

  • Glycosylation at Asn72
  • Modification sites at PhosphoSitePlus

Other Protein References for SCRG1 Gene

No data available for DME Specific Peptides for SCRG1 Gene

Domains & Families for SCRG1 Gene

Protein Domains for SCRG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCRG1 Gene

Graphical View of Domain Structure for InterPro Entry

O75711

UniProtKB/Swiss-Prot:

SCRG1_HUMAN :
  • Belongs to the SCRG1 family.
Family:
  • Belongs to the SCRG1 family.
genes like me logo Genes that share domains with SCRG1: view

No data available for Gene Families for SCRG1 Gene

Function for SCRG1 Gene

Gene Ontology (GO) - Molecular Function for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SCRG1: view
genes like me logo Genes that share phenotypes with SCRG1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCRG1

CRISPR Products

Inhibitory RNA Products

Clone Products

Cell Line Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRG1 Gene

Localization for SCRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCRG1 gene
Compartment Confidence
extracellular 5
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 9660755
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0044306 neuron projection terminus IEA --
genes like me logo Genes that share ontologies with SCRG1: view

Pathways & Interactions for SCRG1 Gene

SuperPathways for SCRG1 Gene

No Data Available

Interacting Proteins for SCRG1 Gene

Gene Ontology (GO) - Biological Process for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9660755
GO:0097168 mesenchymal stem cell proliferation IDA --
genes like me logo Genes that share ontologies with SCRG1: view

No data available for Pathways by source and SIGNOR curated interactions for SCRG1 Gene

Drugs & Compounds for SCRG1 Gene

No Compound Related Data Available

Transcripts for SCRG1 Gene

Unigene Clusters for SCRG1 Gene

Stimulator of chondrogenesis 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRG1 Gene

No ASD Table

Relevant External Links for SCRG1 Gene

GeneLoc Exon Structure for
SCRG1
ECgene alternative splicing isoforms for
SCRG1

Expression for SCRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCRG1 Gene

mRNA differential expression in normal tissues according to GTEx for SCRG1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.2).

Protein differential expression in normal tissues from HIPED for SCRG1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCRG1 Gene



Protein tissue co-expression partners for SCRG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCRG1 Gene:

SCRG1

SOURCE GeneReport for Unigene cluster for SCRG1 Gene:

Hs.7122

mRNA Expression by UniProt/SwissProt for SCRG1 Gene:

O75711-SCRG1_HUMAN
Tissue specificity: Expressed abundantly in the central nervous system of adult, but not at all in fetal brain. High levels of SCRG1 transcripts are also observed in testis and aorta.

Evidence on tissue expression from TISSUES for SCRG1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with SCRG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCRG1 Gene

Orthologs for SCRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCRG1 34 35
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia SCRG1 34 35
  • 92.18 (n)
dog
(Canis familiaris)
Mammalia SCRG1 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scrg1 34 16 35
  • 85.22 (n)
rat
(Rattus norvegicus)
Mammalia Scrg1 34
  • 83.85 (n)
oppossum
(Monodelphis domestica)
Mammalia SCRG1 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCRG1 35
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCRG1 34 35
  • 67.38 (n)
lizard
(Anolis carolinensis)
Reptilia SCRG1 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scrg1 34
  • 69.23 (n)
Species where no ortholog for SCRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCRG1 Gene

ENSEMBL:
Gene Tree for SCRG1 (if available)
TreeFam:
Gene Tree for SCRG1 (if available)

Paralogs for SCRG1 Gene

No data available for Paralogs for SCRG1 Gene

Variants for SCRG1 Gene

Sequence variations from dbSNP and Humsavar for SCRG1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000008031 -- 173,444,010(+) CTCTC(A/G)TCACC intron-variant
rs1000022037 -- 173,440,448(+) GTCCT(C/G)GCTTG intron-variant
rs1000032859 -- 173,396,271(+) CAGTT(A/G)AATGT intron-variant
rs1000050817 -- 173,441,146(+) AAGAA(A/G)CTGAG intron-variant
rs1000054753 -- 173,397,820(+) TGGTA(C/T)TAAGA intron-variant

Variation tolerance for SCRG1 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCRG1 Gene

Disorders for SCRG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCRG1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
scrapie
- elite association - COSMIC cancer census association via MalaCards
Search SCRG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCRG1

Genetic Association Database (GAD)
SCRG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCRG1
genes like me logo Genes that share disorders with SCRG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCRG1 Gene

Publications for SCRG1 Gene

  1. Characterization of the human analogue of a scrapie-responsive gene. (PMID: 9660755) Dron M. … Tovey M.G. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. (PMID: 9516475) Dandoy-Dron F. … Dron M. (J. Biol. Chem. 1998) 2 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for SCRG1 Gene

Sources for SCRG1 Gene

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