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Aliases for SCPEP1 Gene

Aliases for SCPEP1 Gene

  • Serine Carboxypeptidase 1 2 3 4 5
  • RISC 3 4
  • Serine Carboxypeptidase 1 Precursor Protein 3
  • Retinoid Inducible Serine Carboxypeptidase 2
  • Retinoid-Inducible Serine Carboxypeptidase 3
  • EC 3.4.16.- 4
  • EC 3.4.16 61
  • HSCP1 3
  • SCP1 4

External Ids for SCPEP1 Gene

Previous GeneCards Identifiers for SCPEP1 Gene

  • GC17P055531
  • GC17P052410
  • GC17P055055
  • GC17P050416

Summaries for SCPEP1 Gene

GeneCards Summary for SCPEP1 Gene

SCPEP1 (Serine Carboxypeptidase 1) is a Protein Coding gene. GO annotations related to this gene include serine-type carboxypeptidase activity. An important paralog of this gene is CPVL.

UniProtKB/Swiss-Prot for SCPEP1 Gene

  • May be involved in vascular wall and kidney homeostasis.

Gene Wiki entry for SCPEP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCPEP1 Gene

Genomics for SCPEP1 Gene

Regulatory Elements for SCPEP1 Gene

Enhancers for SCPEP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G056911 1.9 FANTOM5 ENCODE dbSUPER 17.5 -63.1 -63114 6.8 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PPARGC1A TRIM25 SCPEP1 ENSG00000262298 ENSG00000274213
GH17G056981 1.2 Ensembl ENCODE 27.7 +5.6 5640 5.3 HDGF PKNOX1 ARNT TCF12 ZNF766 GATA2 ZNF263 CAVIN1 NCOA1 ZNF592 SCPEP1 ENSG00000263120 RNF126P1
GH17G056977 1 ENCODE 27.8 +0.2 162 2.4 HDGF WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZBTB7B YY1 TCF12 SCPEP1 ENSG00000263120
GH17G056960 1.1 ENCODE 24.8 -17.2 -17165 1.5 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SCPEP1 GC17M056963 PIR58151 LOC100419768
GH17G056909 1.6 FANTOM5 ENCODE dbSUPER 16.3 -67.7 -67660 1.3 PKNOX1 ATF1 ARNT WRNIP1 ARID4B YY1 TCF12 ZNF121 ZNF766 GATA2 TRIM25 SCPEP1 MIR3614
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCPEP1 on UCSC Golden Path with GeneCards custom track

Promoters for SCPEP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096053 95 1601 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZBTB7B YY1 TCF12 ZNF121

Genomic Location for SCPEP1 Gene

56,978,105 bp from pter
57,006,768 bp from pter
28,664 bases
Plus strand

Genomic View for SCPEP1 Gene

Genes around SCPEP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCPEP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCPEP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCPEP1 Gene

Proteins for SCPEP1 Gene

  • Protein details for SCPEP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinoid-inducible serine carboxypeptidase
    Protein Accession:
    Secondary Accessions:
    • Q96A94
    • Q9H3F0

    Protein attributes for SCPEP1 Gene

    452 amino acids
    Molecular mass:
    50831 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCPEP1 Gene


neXtProt entry for SCPEP1 Gene

Selected DME Specific Peptides for SCPEP1 Gene


Post-translational modifications for SCPEP1 Gene

  • Ubiquitination at isoforms=2243
  • Glycosylation at isoforms=264, isoforms=2126, and isoforms=362
  • Modification sites at PhosphoSitePlus

Domains & Families for SCPEP1 Gene

Gene Families for SCPEP1 Gene

Protein Domains for SCPEP1 Gene

Suggested Antigen Peptide Sequences for SCPEP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S10 family.
  • Belongs to the peptidase S10 family.
genes like me logo Genes that share domains with SCPEP1: view

Function for SCPEP1 Gene

Molecular function for SCPEP1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in vascular wall and kidney homeostasis.

Enzyme Numbers (IUBMB) for SCPEP1 Gene

Gene Ontology (GO) - Molecular Function for SCPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004185 serine-type carboxypeptidase activity ISS,IEA --
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SCPEP1: view
genes like me logo Genes that share phenotypes with SCPEP1: view

Animal Models for SCPEP1 Gene

MGI Knock Outs for SCPEP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SCPEP1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SCPEP1 Gene

Localization for SCPEP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCPEP1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCPEP1 gene
Compartment Confidence
extracellular 5
cytosol 5
golgi apparatus 3
lysosome 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SCPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005829 cytosol ISS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SCPEP1: view

Pathways & Interactions for SCPEP1 Gene

SuperPathways for SCPEP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0042573 retinoic acid metabolic process ISS --
GO:0045776 negative regulation of blood pressure ISS --
GO:0045909 positive regulation of vasodilation ISS --
GO:0051603 proteolysis involved in cellular protein catabolic process IBA --
genes like me logo Genes that share ontologies with SCPEP1: view

No data available for Pathways by source and SIGNOR curated interactions for SCPEP1 Gene

Drugs & Compounds for SCPEP1 Gene

(1) Drugs for SCPEP1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-BENZYLSUCCINIC ACID Experimental Pharma Target 0
genes like me logo Genes that share compounds with SCPEP1: view

Transcripts for SCPEP1 Gene

Unigene Clusters for SCPEP1 Gene

Serine carboxypeptidase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCPEP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ·
SP1: - - - - - -
SP2: - - - - -
SP4: - - - - - -
SP6: -
SP7: - - - - - -

ExUns: 14d

Relevant External Links for SCPEP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCPEP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCPEP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCPEP1 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for SCPEP1 Gene

This gene is overexpressed in Adrenal (11.5), Nasal epithelium (11.4), and Seminal vesicle (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCPEP1 Gene

Protein tissue co-expression partners for SCPEP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCPEP1 Gene:


SOURCE GeneReport for Unigene cluster for SCPEP1 Gene:


Evidence on tissue expression from TISSUES for SCPEP1 Gene

  • Eye(4.2)
  • Liver(4.2)
  • Nervous system(4.2)
  • Lung(2.5)
  • Kidney(2.2)
  • Adrenal gland(2)
  • Blood(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SCPEP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCPEP1 Gene

Orthologs for SCPEP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCPEP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCPEP1 34 35
  • 99.19 (n)
(Canis familiaris)
Mammalia SCPEP1 34 35
  • 89.7 (n)
(Bos Taurus)
Mammalia SCPEP1 34 35
  • 84 (n)
(Rattus norvegicus)
Mammalia Scpep1 34
  • 82.37 (n)
(Mus musculus)
Mammalia Scpep1 34 16 35
  • 82.15 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
-- 35
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia SCPEP1 35
  • 70 (a)
(Gallus gallus)
Aves SCPEP1 34 35
  • 69.6 (n)
(Anolis carolinensis)
Reptilia SCPEP1 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scpep1 34
  • 65.96 (n)
(Danio rerio)
Actinopterygii scpep1 34 35
  • 66.67 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011442 34
  • 49.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32483 34 35
  • 49.55 (n)
CG3344 35
  • 37 (a)
CG31823 35
  • 33 (a)
CG31821 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y32F6A.5 34
  • 51.35 (n)
Y32F6A.5 35
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEX1 35
  • 15 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SCPL51 34
  • 53.14 (n)
(Oryza sativa)
Liliopsida Os08g0560500 34
  • 53.54 (n)
Os.7754 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
Species where no ortholog for SCPEP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCPEP1 Gene

Gene Tree for SCPEP1 (if available)
Gene Tree for SCPEP1 (if available)

Paralogs for SCPEP1 Gene

Paralogs for SCPEP1 Gene

(1) SIMAP similar genes for SCPEP1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SCPEP1: view

Variants for SCPEP1 Gene

Sequence variations from dbSNP and Humsavar for SCPEP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000028895 -- 56,996,506(+) GGCCT(C/T)TTTTT intron-variant
rs1000049789 -- 57,006,853(+) TTTCT(A/G)GTTTG downstream-variant-500B
rs1000059903 -- 56,996,370(+) CAGCT(A/G)ATTTT intron-variant
rs1000573656 -- 56,981,986(+) TTCGT(A/G)TGACT intron-variant
rs1000871268 -- 56,984,034(+) CCCCC(A/G)AGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCPEP1 Gene

Variant ID Type Subtype PubMed ID
esv32884 CNV loss 17666407
esv3328686 CNV duplication 20981092
esv3554586 CNV deletion 23714750
esv3640863 CNV loss 21293372

Variation tolerance for SCPEP1 Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCPEP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCPEP1 Gene

Disorders for SCPEP1 Gene

Relevant External Links for SCPEP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCPEP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCPEP1 Gene

Publications for SCPEP1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells. (PMID: 11447226) Chen J. … Miano J.M. (J. Biol. Chem. 2001) 2 3 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SCPEP1 Gene

Sources for SCPEP1 Gene

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