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Aliases for SCPEP1 Gene

Aliases for SCPEP1 Gene

  • Serine Carboxypeptidase 1 2 3 4 5
  • Retinoid Inducible Serine Carboxypeptidase 2 3
  • RISC 3 4
  • Serine Carboxypeptidase 1 Precursor Protein 3
  • EC 3.4.16.- 4
  • EC 3.4.16 63
  • HSCP1 3
  • SCP1 4

External Ids for SCPEP1 Gene

Previous GeneCards Identifiers for SCPEP1 Gene

  • GC17P055531
  • GC17P052410
  • GC17P055055
  • GC17P050416

Summaries for SCPEP1 Gene

GeneCards Summary for SCPEP1 Gene

SCPEP1 (Serine Carboxypeptidase 1) is a Protein Coding gene. GO annotations related to this gene include serine-type carboxypeptidase activity. An important paralog of this gene is CPVL.

UniProtKB/Swiss-Prot for SCPEP1 Gene

  • May be involved in vascular wall and kidney homeostasis.

Gene Wiki entry for SCPEP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCPEP1 Gene

Genomics for SCPEP1 Gene

Regulatory Elements for SCPEP1 Gene

Enhancers for SCPEP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCPEP1 on UCSC Golden Path with GeneCards custom track

Promoters for SCPEP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCPEP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCPEP1 Gene

56,978,105 bp from pter
57,006,768 bp from pter
28,664 bases
Plus strand

Genomic View for SCPEP1 Gene

Genes around SCPEP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCPEP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCPEP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCPEP1 Gene

Proteins for SCPEP1 Gene

  • Protein details for SCPEP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinoid-inducible serine carboxypeptidase
    Protein Accession:
    Secondary Accessions:
    • Q96A94
    • Q9H3F0

    Protein attributes for SCPEP1 Gene

    452 amino acids
    Molecular mass:
    50831 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCPEP1 Gene


neXtProt entry for SCPEP1 Gene

Proteomics data for SCPEP1 Gene at MOPED

Selected DME Specific Peptides for SCPEP1 Gene

Post-translational modifications for SCPEP1 Gene

  • Ubiquitination at Lys 243
  • Glycosylation at Asn 64, Asn 126, and Asn 362
  • Modification sites at PhosphoSitePlus

Domains & Families for SCPEP1 Gene

Gene Families for SCPEP1 Gene

Protein Domains for SCPEP1 Gene

Suggested Antigen Peptide Sequences for SCPEP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S10 family.
  • Belongs to the peptidase S10 family.
genes like me logo Genes that share domains with SCPEP1: view

Function for SCPEP1 Gene

Molecular function for SCPEP1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in vascular wall and kidney homeostasis.

Enzyme Numbers (IUBMB) for SCPEP1 Gene

genes like me logo Genes that share phenotypes with SCPEP1: view

Animal Models for SCPEP1 Gene

MGI Knock Outs for SCPEP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SCPEP1

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SCPEP1 Gene

Localization for SCPEP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCPEP1 Gene


Subcellular locations from

Jensen Localization Image for SCPEP1 Gene COMPARTMENTS Subcellular localization image for SCPEP1 gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 3
lysosome 2
vacuole 2
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SCPEP1 Gene

Pathways & Interactions for SCPEP1 Gene

SuperPathways for SCPEP1 Gene

No Data Available

Interacting Proteins for SCPEP1 Gene

Gene Ontology (GO) - Biological Process for SCPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042573 retinoic acid metabolic process ISS --
GO:0045776 negative regulation of blood pressure ISS --
GO:0051603 proteolysis involved in cellular protein catabolic process IBA --
genes like me logo Genes that share ontologies with SCPEP1: view

No data available for Pathways by source and SIGNOR curated interactions for SCPEP1 Gene

Drugs & Compounds for SCPEP1 Gene

(1) Drugs for SCPEP1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-BENZYLSUCCINIC ACID Experimental Pharma Target 0
genes like me logo Genes that share compounds with SCPEP1: view

Transcripts for SCPEP1 Gene

Unigene Clusters for SCPEP1 Gene

Serine carboxypeptidase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCPEP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ·
SP1: - - - - - -
SP2: - - - - -
SP4: - - - - - -
SP6: -
SP7: - - - - - -

ExUns: 14d

Relevant External Links for SCPEP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCPEP1 Gene

mRNA expression in normal human tissues for SCPEP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCPEP1 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for SCPEP1 Gene

This gene is overexpressed in Adrenal (11.5), Nasal epithelium (11.4), and Seminal vesicle (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCPEP1 Gene

SOURCE GeneReport for Unigene cluster for SCPEP1 Gene Hs.514950

genes like me logo Genes that share expression patterns with SCPEP1: view

Protein tissue co-expression partners for SCPEP1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SCPEP1 Gene

Orthologs for SCPEP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCPEP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCPEP1 35
  • 84 (n)
  • 80.13 (a)
  • 80 (a)
(Canis familiaris)
Mammalia SCPEP1 35
  • 89.7 (n)
  • 90.63 (a)
  • 87 (a)
(Mus musculus)
Mammalia Scpep1 35
  • 82.15 (n)
  • 82.3 (a)
Scpep1 16
Scpep1 36
  • 82 (a)
(Pan troglodytes)
Mammalia SCPEP1 35
  • 99.19 (n)
  • 98.67 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Scpep1 35
  • 82.37 (n)
  • 82.74 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
-- 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia SCPEP1 36
  • 70 (a)
(Gallus gallus)
Aves SCPEP1 35
  • 69.6 (n)
  • 68.88 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia SCPEP1 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scpep1 35
  • 65.96 (n)
  • 66.28 (a)
(Danio rerio)
Actinopterygii -- 35
scpep1 35
  • 66.67 (n)
  • 65.79 (a)
scpep1 36
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011442 35
  • 49.58 (n)
  • 40.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32483 35
  • 49.55 (n)
  • 40.83 (a)
CG31821 36
  • 31 (a)
CG31823 36
  • 33 (a)
CG32483 36
  • 38 (a)
CG3344 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y32F6A.5 35
  • 51.35 (n)
  • 44.96 (a)
Y32F6A.5 36
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEX1 36
  • 15 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SCPL51 35
  • 53.14 (n)
  • 46.86 (a)
(Oryza sativa)
Liliopsida Os.7754 35
Os08g0560500 35
  • 53.54 (n)
  • 48.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for SCPEP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCPEP1 Gene

Gene Tree for SCPEP1 (if available)
Gene Tree for SCPEP1 (if available)

Paralogs for SCPEP1 Gene

Paralogs for SCPEP1 Gene

(1) SIMAP similar genes for SCPEP1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SCPEP1: view

Variants for SCPEP1 Gene

Sequence variations from dbSNP and Humsavar for SCPEP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34108204 - 56,978,166(-) TGCCA(C/G/T)CTCCA reference, missense
rs16957938 - 56,995,570(+) ATGCC(A/G)TAAAT reference, missense
rs964233 -- 56,990,856(-) GGAGG(C/T)CGAGG intron-variant
rs964234 -- 56,990,656(-) AGCAA(A/G)ATCCT intron-variant
rs748392 -- 57,003,432(+) AAGTA(G/T)ATGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCPEP1 Gene

Variant ID Type Subtype PubMed ID
esv32884 CNV Loss 17666407

Variation tolerance for SCPEP1 Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SCPEP1 Gene

Disorders for SCPEP1 Gene

Relevant External Links for SCPEP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCPEP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCPEP1 Gene

Publications for SCPEP1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells. (PMID: 11447226) Chen J. … Miano J.M. (J. Biol. Chem. 2001) 2 3 23
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases. (PMID: 24530914) Schreuder H.A. … Sadowski T. (Biochem. Biophys. Res. Commun. 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for SCPEP1 Gene

Sources for SCPEP1 Gene