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Aliases for SCPEP1 Gene

Aliases for SCPEP1 Gene

  • Serine Carboxypeptidase 1 2 3 4
  • Retinoid Inducible Serine Carboxypeptidase 2 3
  • RISC 3 4
  • Serine Carboxypeptidase 1 Precursor Protein 3
  • Retinoid-Inducible Serine Carboxypeptidase 3
  • EC 3.4.16.- 4
  • EC 3.4.16 63
  • HSCP1 3
  • SCP1 4

External Ids for SCPEP1 Gene

Previous GeneCards Identifiers for SCPEP1 Gene

  • GC17P055531
  • GC17P052410
  • GC17P055055
  • GC17P050416

Summaries for SCPEP1 Gene

GeneCards Summary for SCPEP1 Gene

SCPEP1 (Serine Carboxypeptidase 1) is a Protein Coding gene. Diseases associated with SCPEP1 include retinal perforation. GO annotations related to this gene include serine-type carboxypeptidase activity.

UniProtKB/Swiss-Prot for SCPEP1 Gene

  • May be involved in vascular wall and kidney homeostasis.

Gene Wiki entry for SCPEP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCPEP1 Gene

Genomics for SCPEP1 Gene

Regulatory Elements for SCPEP1 Gene

Genomic Location for SCPEP1 Gene

Start:
56,978,105 bp from pter
End:
57,006,768 bp from pter
Size:
28,664 bases
Orientation:
Plus strand

Genomic View for SCPEP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCPEP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCPEP1 Gene

Proteins for SCPEP1 Gene

  • Protein details for SCPEP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB40-RISC_HUMAN
    Recommended name:
    Retinoid-inducible serine carboxypeptidase
    Protein Accession:
    Q9HB40
    Secondary Accessions:
    • Q96A94
    • Q9H3F0

    Protein attributes for SCPEP1 Gene

    Size:
    452 amino acids
    Molecular mass:
    50831 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCPEP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCPEP1 Gene

Proteomics data for SCPEP1 Gene at MOPED

Selected DME Specific Peptides for SCPEP1 Gene

Post-translational modifications for SCPEP1 Gene

  • Ubiquitination at Lys243
  • Glycosylation at Asn64, Asn126, and Asn362
  • Modification sites at PhosphoSitePlus

Other Protein References for SCPEP1 Gene

Antibody Products

Domains for SCPEP1 Gene

Gene Families for SCPEP1 Gene

Protein Domains for SCPEP1 Gene

Suggested Antigen Peptide Sequences for SCPEP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HB40

UniProtKB/Swiss-Prot:

RISC_HUMAN :
  • Q9HB40
Family:
  • Belongs to the peptidase S10 family.
genes like me logo Genes that share domains with SCPEP1: view

Function for SCPEP1 Gene

Molecular function for SCPEP1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in vascular wall and kidney homeostasis.

Enzyme Numbers (IUBMB) for SCPEP1 Gene

Gene Ontology (GO) - Molecular Function for SCPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004185 serine-type carboxypeptidase activity ISS --
genes like me logo Genes that share ontologies with SCPEP1: view

Phenotypes for SCPEP1 Gene

genes like me logo Genes that share phenotypes with SCPEP1: view

Animal Models for SCPEP1 Gene

MGI Knock Outs for SCPEP1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCPEP1

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for SCPEP1 Gene

Localization for SCPEP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCPEP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCPEP1 Gene COMPARTMENTS Subcellular localization image for SCPEP1 gene
Compartment Confidence
extracellular 3
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SCPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol ISS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SCPEP1: view

Pathways for SCPEP1 Gene

SuperPathways for SCPEP1 Gene

No Data Available

Interacting Proteins for SCPEP1 Gene

Gene Ontology (GO) - Biological Process for SCPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0042573 retinoic acid metabolic process ISS --
GO:0045776 negative regulation of blood pressure ISS --
GO:0045909 positive regulation of vasodilation ISS --
genes like me logo Genes that share ontologies with SCPEP1: view

No data available for Pathways by source for SCPEP1 Gene

Compounds for SCPEP1 Gene

(1) Drugbank Compounds for SCPEP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-BENZYLSUCCINIC ACID
target
genes like me logo Genes that share compounds with SCPEP1: view

Transcripts for SCPEP1 Gene

Unigene Clusters for SCPEP1 Gene

Serine carboxypeptidase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCPEP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCPEP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ·
SP1: - - - - - -
SP2: - - - - -
SP3:
SP4: - - - - - -
SP5:
SP6: -
SP7: - - - - - -

ExUns: 14d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for SCPEP1 Gene

GeneLoc Exon Structure for
SCPEP1
ECgene alternative splicing isoforms for
SCPEP1

Expression for SCPEP1 Gene

mRNA expression in normal human tissues for SCPEP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCPEP1 Gene

This gene is overexpressed in Whole Blood (4.6).

Protein differential expression in normal tissues for SCPEP1 Gene

This gene is overexpressed in Adrenal (11.5), Nasal epithelium (11.4), and Seminal vesicle (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCPEP1 Gene

SOURCE GeneReport for Unigene cluster for SCPEP1 Gene Hs.514950

genes like me logo Genes that share expressions with SCPEP1: view

Expression partners for SCPEP1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SCPEP1 Gene

Orthologs for SCPEP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCPEP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCPEP1 35
  • 84 (n)
  • 80.13 (a)
SCPEP1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCPEP1 35
  • 89.7 (n)
  • 90.63 (a)
SCPEP1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scpep1 35
  • 82.15 (n)
  • 82.3 (a)
Scpep1 16
Scpep1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCPEP1 35
  • 99.19 (n)
  • 98.67 (a)
SCPEP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scpep1 35
  • 82.37 (n)
  • 82.74 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SCPEP1 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCPEP1 35
  • 69.6 (n)
  • 68.88 (a)
SCPEP1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCPEP1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scpep1 35
  • 65.96 (n)
  • 66.28 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
scpep1 35
  • 66.67 (n)
  • 65.79 (a)
scpep1 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011442 35
  • 49.58 (n)
  • 40.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32483 35
  • 49.55 (n)
  • 40.83 (a)
CG31821 36
  • 31 (a)
OneToMany
CG31823 36
  • 33 (a)
OneToMany
CG32483 36
  • 38 (a)
OneToMany
CG3344 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y32F6A.5 35
  • 51.35 (n)
  • 44.96 (a)
Y32F6A.5 36
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEX1 36
  • 15 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons SCPL51 35
  • 53.14 (n)
  • 46.86 (a)
rice
(Oryza sativa)
Liliopsida Os.7754 35
Os08g0560500 35
  • 53.54 (n)
  • 48.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for SCPEP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCPEP1 Gene

ENSEMBL:
Gene Tree for SCPEP1 (if available)
TreeFam:
Gene Tree for SCPEP1 (if available)

Paralogs for SCPEP1 Gene

Selected SIMAP similar genes for SCPEP1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SCPEP1: view

No data available for Paralogs for SCPEP1 Gene

Variants for SCPEP1 Gene

Sequence variations from dbSNP and Humsavar for SCPEP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs748392 -- 57,003,432(+) AAGTA(G/T)ATGGA intron-variant
rs964233 -- 56,990,856(-) GGAGG(C/T)CGAGG intron-variant
rs964234 -- 56,990,656(-) AGCAA(A/G)ATCCT intron-variant
rs1811258 -- 56,998,221(-) CGATT(C/T)TCCTG intron-variant
rs1981722 -- 57,007,184(-) tcggc(C/T)aatgt downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SCPEP1 Gene

Variant ID Type Subtype PubMed ID
esv32884 CNV Loss 17666407

Relevant External Links for SCPEP1 Gene

HapMap Linkage Disequilibrium report
SCPEP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCPEP1 Gene

Disorders for SCPEP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SCPEP1 Gene in MalaCards »

(1) Diseases for SCPEP1 Gene including...

(1) University of Copenhagen DISEASES for SCPEP1 Gene

genes like me logo Genes that share disorders with SCPEP1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SCPEP1 Gene

Publications for SCPEP1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells. (PMID: 11447226) Chen J. … Miano J.M. (J. Biol. Chem. 2001) 2 3 23
  3. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PMID: 12754519) Zhang H. … Aebersold R. (Nat. Biotechnol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for SCPEP1 Gene

Sources for SCPEP1 Gene

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