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Aliases for SCP2 Gene

Aliases for SCP2 Gene

  • Sterol Carrier Protein 2 2 3 4
  • Propanoyl-CoA C-Acyltransferase 3 4
  • Sterol Carrier Protein X 3 4
  • EC 4 63
  • SCP-CHI 3 4
  • NSL-TP 3 4
  • SCP-2 3 4
  • SCP-X 3 4
  • SCPX 3 4
  • NLTP 3

External Ids for SCP2 Gene

Previous GeneCards Identifiers for SCP2 Gene

  • GC01P052944
  • GC01P052282
  • GC01P052751
  • GC01P052762
  • GC01P053105
  • GC01P053165
  • GC01P053392
  • GC01P051508

Summaries for SCP2 Gene

Entrez Gene Summary for SCP2 Gene

  • This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]

GeneCards Summary for SCP2 Gene

SCP2 (Sterol Carrier Protein 2) is a Protein Coding gene. Diseases associated with SCP2 include leukoencephalopathy with dystonia and motor neuropathy and yellow fever. Among its related pathways are Metabolism and Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF). GO annotations related to this gene include receptor binding and cholesterol binding. An important paralog of this gene is HSD17B4.

UniProtKB/Swiss-Prot for SCP2 Gene

  • Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.

Gene Wiki entry for SCP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCP2 Gene

Genomics for SCP2 Gene

Regulatory Elements for SCP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCP2 Gene

52,927,229 bp from pter
53,051,703 bp from pter
124,475 bases
Plus strand

Genomic View for SCP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCP2 Gene

Proteins for SCP2 Gene

  • Protein details for SCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Non-specific lipid-transfer protein
    Protein Accession:
    Secondary Accessions:
    • A6NM69
    • B4DGJ9
    • B4DHP6
    • C9JC79
    • D3DQ37
    • E1B6W5
    • F2Z3J1
    • Q15432
    • Q16622
    • Q5VVZ1
    • Q6NXF4
    • Q99430

    Protein attributes for SCP2 Gene

    547 amino acids
    Molecular mass:
    58994 Da
    Quaternary structure:
    • Interacts with PEX5.
    • Sequence=AAA03558.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SCP2 Gene

    Alternative splice isoforms for SCP2 Gene

neXtProt entry for SCP2 Gene

Proteomics data for SCP2 Gene at MOPED

Post-translational modifications for SCP2 Gene

  • Ubiquitination at Lys 453
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SCP2

Domains & Families for SCP2 Gene

Suggested Antigen Peptide Sequences for SCP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SCP2 domain.
  • In the N-terminal section; belongs to the thiolase family.
  • Contains 1 SCP2 domain.
  • In the N-terminal section; belongs to the thiolase family.
genes like me logo Genes that share domains with SCP2: view

No data available for Gene Families for SCP2 Gene

Function for SCP2 Gene

Molecular function for SCP2 Gene

GENATLAS Biochemistry:
sterol carrier protein X (58kDa) peroxisomal thiolase cleaving 2-methyl branched chains and sterol carrier protein 2 (15.3kDa),an alternative transcript within the C terminal part of SCPX,potentially involved in intracellular lipid transport
UniProtKB/Swiss-Prot CatalyticActivity:
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoA
UniProtKB/Swiss-Prot Function:
Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by 4-hydroxy-tamoxifen.

Enzyme Numbers (IUBMB) for SCP2 Gene

Gene Ontology (GO) - Molecular Function for SCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IDA 18465878
GO:0003824 catalytic activity --
GO:0005102 receptor binding IPI 20178365
GO:0005515 protein binding IPI 15182174
GO:0008526 phosphatidylinositol transporter activity IDA 12641450
genes like me logo Genes that share ontologies with SCP2: view
genes like me logo Genes that share phenotypes with SCP2: view

Animal Models for SCP2 Gene

MGI Knock Outs for SCP2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCP2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for SCP2 Gene

Localization for SCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCP2 Gene

Cytoplasm. Mitochondrion. Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues.
Isoform SCPx: Peroxisome. Note=Interaction with PEX5 is essential for peroxisomal import.
Isoform SCP2: Mitochondrion.

Subcellular locations from

Jensen Localization Image for SCP2 Gene COMPARTMENTS Subcellular localization image for SCP2 gene
Compartment Confidence
extracellular 5
peroxisome 5
nucleus 4
mitochondrion 3
cytosol 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IDA 1347505
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with SCP2: view

Pathways & Interactions for SCP2 Gene

genes like me logo Genes that share pathways with SCP2: view

Gene Ontology (GO) - Biological Process for SCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process IDA 1703300
GO:0006699 bile acid biosynthetic process TAS --
GO:0006701 progesterone biosynthetic process IDA 1703300
GO:0006869 lipid transport --
GO:0007031 peroxisome organization IEA --
genes like me logo Genes that share ontologies with SCP2: view

No data available for SIGNOR curated interactions for SCP2 Gene

Drugs & Compounds for SCP2 Gene

(10) Drugs for SCP2 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Neomycin Approved Pharma 37
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
Phosphatidylserine Approved Nutra 0
Propionyl-CoA Experimental Pharma 0
cholesterol Experimental Pharma Agonist 0

(22) Additional Compounds for SCP2 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (-)-7-dehydrocholesterol
  • (3b)-Cholesta-5,7-dien-3-ol
  • (3beta)-Cholesta-5,7-dien-3-ol
  • 10,13-Dimethyl-17-(6-methylheptan-2-yl)-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
  • 17-(1,5-Dimethylhexyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
  • (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA
  • (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-Coenzyme A
  • 24-Oxo-25(R)-trihydroxycoprostanoyl-CoA
  • 24-Oxo-25(R)-trihydroxycoprostanoyl-Coenzyme A
  • 25(R)-24-Oxo-3alpha,7alpha,12alpha-trihydroxycoprostanoyl-CoA
  • 3a,7a-Dihydroxy-5b-24-oxocholestanoyl-CoA
  • 3a,7a-Dihydroxy-5b-24-oxocholestanoyl-Coenzyme A
  • 3alpha,7alpha-Dihydroxy-5beta-24-oxocholestanoyl-CoA
  • 3alpha,7alpha-Dihydroxy-5beta-24-oxocholestanoyl-Coenzyme A
  • 5'-{3-[(3R)-4-{[3-({2-[(3alpha,7alpha-dihydroxy-5beta-cholan-24-oyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl] dihydrogen diphosphate}3'-phosphoadenosine
  • Chenodeoxycholoyl coenzyme a
  • 7-alpha-12-alpha-Dihydroxy-3-oxo-5-beta-cholyl-Coa
  • Choloyl-CoA
  • Choloyl-Coenzyme A
  • Cholyl-CoA
  • Cholyl-Coenzyme A
genes like me logo Genes that share compounds with SCP2: view

Transcripts for SCP2 Gene

Unigene Clusters for SCP2 Gene

Sterol carrier protein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: -
SP2: - -
SP4: - -
SP5: - - - -
SP6: -

Relevant External Links for SCP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCP2 Gene

mRNA expression in normal human tissues for SCP2 Gene

mRNA differential expression in normal tissues according to GTEx for SCP2 Gene

This gene is overexpressed in Liver (x7.8).

Protein differential expression in normal tissues from HIPED for SCP2 Gene

This gene is overexpressed in Liver (10.4), Liver, secretome (10.0), and Milk (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCP2 Gene

SOURCE GeneReport for Unigene cluster for SCP2 Gene Hs.476365

mRNA Expression by UniProt/SwissProt for SCP2 Gene

Tissue specificity: Liver, fibroblasts, and placenta
genes like me logo Genes that share expression patterns with SCP2: view

Protein tissue co-expression partners for SCP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCP2 Gene

Orthologs for SCP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SCP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCP2 35
  • 90.02 (n)
  • 87.57 (a)
SCP2 36
  • 86 (a)
(Canis familiaris)
Mammalia SCP2 35
  • 90.42 (n)
  • 88.43 (a)
SCP2 36
  • 87 (a)
(Mus musculus)
Mammalia Scp2 35
  • 86.05 (n)
  • 89.21 (a)
Scp2 16
Scp2 36
  • 89 (a)
(Pan troglodytes)
Mammalia SCP2 35
  • 99.7 (n)
  • 99.63 (a)
SCP2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Scp2 35
  • 84.46 (n)
  • 86.47 (a)
(Monodelphis domestica)
Mammalia SCP2 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia SCP2 36
  • 83 (a)
(Gallus gallus)
Aves SCP2 35
  • 74.78 (n)
  • 79.24 (a)
SCP2 36
  • 76 (a)
(Anolis carolinensis)
Reptilia SCP2 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scp2 35
  • 72.19 (n)
  • 79.28 (a)
Str.17130 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24309 35
(Danio rerio)
Actinopterygii scp2a 35
  • 70.22 (n)
  • 76.59 (a)
zgc77634 35
scp2a 36
  • 75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4325 35
fruit fly
(Drosophila melanogaster)
Insecta CG17597 37
  • 63 (a)
ScpX 37
  • 57 (a)
ScpX 35
  • 58.48 (n)
  • 59.62 (a)
CG17597 36
  • 61 (a)
ScpX 36
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007921 35
  • 56.65 (n)
  • 58.94 (a)
(Caenorhabditis elegans)
Secernentea Y57A10C.6 37
  • 58 (a)
daf-22 35
  • 59.8 (n)
  • 59.06 (a)
daf-22 36
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FOX2 36
  • 9 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2009 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03372 35
  • 56.15 (n)
  • 55.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
CSA.3842 36
  • 60 (a)
Species with no ortholog for SCP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCP2 Gene

Gene Tree for SCP2 (if available)
Gene Tree for SCP2 (if available)

Paralogs for SCP2 Gene

Paralogs for SCP2 Gene Pseudogenes for SCP2 Gene

genes like me logo Genes that share paralogs with SCP2: view

Variants for SCP2 Gene

Sequence variations from dbSNP and Humsavar for SCP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8871 -- 53,051,327(+) TCCTT(A/C)TTGAA utr-variant-3-prime
rs13496 -- 53,051,070(+) ATTCA(A/G)TTTAA utr-variant-3-prime
rs768333 -- 52,931,821(-) TTTTC(C/T)TTAGT intron-variant
rs959691 -- 52,931,711(-) aaagc(C/T)tgaag intron-variant
rs1049891 -- 53,051,357(+) AAAAC(A/C)CCATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SCP2 Gene

Variant ID Type Subtype PubMed ID
nsv870582 CNV Gain 21882294
nsv870668 CNV Loss 21882294
esv2669916 CNV Deletion 23128226
nsv870947 CNV Loss 21882294
nsv10150 CNV Gain 18304495
nsv441693 CNV CNV 18776908
dgv51e1 CNV Complex 17122850
nsv514927 CNV Complex 21397061
dgv36n67 CNV Loss 20364138
nsv522862 CNV Loss 19592680
essv13816 CNV CNV 17122850

Variation tolerance for SCP2 Gene

Residual Variation Intolerance Score: 13.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCP2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCP2 Gene

Disorders for SCP2 Gene

MalaCards: The human disease database

(13) MalaCards diseases for SCP2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
leukoencephalopathy with dystonia and motor neuropathy
  • leukoencephalopathy - dystonia - motor neuropathy
yellow fever
  • sylvatic yellow fever
lipoid adrenal hyperplasia
  • lipoid cah
peroxisomal acyl-coa oxidase deficiency
  • peroxisomal acyl-coenzyme a oxidase
d-bifunctional protein deficiency
  • 17-beta-hydroxysteroid dehydrogenase iv deficiency
- elite association
Search SCP2 in MalaCards View complete list of genes associated with diseases


  • Leukoencephalopathy, with dystonia and motor neuropathy (LDMN) [MIM:613724]: A syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine. {ECO:0000269 PubMed:16685654}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SCP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SCP2: view

No data available for Genatlas for SCP2 Gene

Publications for SCP2 Gene

  1. Cloning and expression of a cDNA encoding human sterol carrier protein 2. (PMID: 1703300) Yamamoto R. … Strauss J.F. III (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 23 67
  2. cDNAs encoding members of a family of proteins related to human sterol carrier protein 2 and assignment of the gene to human chromosome 1 p21-pter. (PMID: 1718316) He Z. … Strauss J.F. III (DNA Cell Biol. 1991) 2 23 67
  3. Pichia pastoris is superior to E. coli for the production of recombinant allergenic non-specific lipid-transfer proteins. (PMID: 19733242) Pokoj S. … Scheurer S. (Protein Expr. Purif. 2010) 23 67
  4. Caveolin, sterol carrier protein-2, membrane cholesterol-rich microdomains and intracellular cholesterol trafficking. (PMID: 20213548) Schroeder F. … Kier A.B. (Subcell. Biochem. 2010) 23 67
  5. Biochemical, immunological and clinical characterization of a cross-reactive nonspecific lipid transfer protein 1 from mulberry. (PMID: 19958316) Ciardiello M.A. … Colombo P. (Allergy 2010) 23 67

Products for SCP2 Gene

Sources for SCP2 Gene

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