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Aliases for SCP2 Gene

Aliases for SCP2 Gene

  • Sterol Carrier Protein 2 2 3 4
  • Propanoyl-CoA C-Acyltransferase 3 4
  • Sterol Carrier Protein X 3 4
  • EC 2.3.1.176 4 64
  • SCP-CHI 3 4
  • NSL-TP 3 4
  • SCP-2 3 4
  • SCP-X 3 4
  • SCPX 3 4
  • Non-Specific Lipid-Transfer Protein 3
  • NLTP 3

External Ids for SCP2 Gene

Summaries for SCP2 Gene

Entrez Gene Summary for SCP2 Gene

  • This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]

GeneCards Summary for SCP2 Gene

SCP2 (Sterol Carrier Protein 2) is a Protein Coding gene. Diseases associated with SCP2 include leukoencephalopathy with dystonia and motor neuropathy and yellow fever. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include receptor binding and fatty-acyl-CoA binding. An important paralog of this gene is HSD17B4.

UniProtKB/Swiss-Prot for SCP2 Gene

  • Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.

Gene Wiki entry for SCP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCP2 Gene

Genomics for SCP2 Gene

Genomic Location for SCP2 Gene

Start:
52,927,229 bp from pter
End:
53,051,703 bp from pter
Size:
124,475 bases
Orientation:
Plus strand

Genomic View for SCP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCP2 Gene

Regulatory Elements for SCP2 Gene

Proteins for SCP2 Gene

  • Protein details for SCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22307-NLTP_HUMAN
    Recommended name:
    Non-specific lipid-transfer protein
    Protein Accession:
    P22307
    Secondary Accessions:
    • A6NM69
    • B4DGJ9
    • B4DHP6
    • C9JC79
    • D3DQ37
    • E1B6W5
    • F2Z3J1
    • Q15432
    • Q16622
    • Q5VVZ1
    • Q6NXF4
    • Q99430

    Protein attributes for SCP2 Gene

    Size:
    547 amino acids
    Molecular mass:
    58994 Da
    Quaternary structure:
    • Interacts with PEX5.
    SequenceCaution:
    • Sequence=AAA03558.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SCP2 Gene

    Alternative splice isoforms for SCP2 Gene

neXtProt entry for SCP2 Gene

Proteomics data for SCP2 Gene at MOPED

Post-translational modifications for SCP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys453

Domains for SCP2 Gene

UniProtKB/Swiss-Prot:

NLTP_HUMAN
Domain:
  • Contains 1 SCP2 domain.:
    • P22307
Family:
  • In the N-terminal section; belongs to the thiolase family.:
    • P22307
genes like me logo Genes that share domains with SCP2: view

No data available for Gene Families for SCP2 Gene

Function for SCP2 Gene

Molecular function for SCP2 Gene

GENATLAS Biochemistry: sterol carrier protein X (58kDa) peroxisomal thiolase cleaving 2-methyl branched chains and sterol carrier protein 2 (15.3kDa),an alternative transcript within the C terminal part of SCPX,potentially involved in intracellular lipid transport
UniProtKB/Swiss-Prot CatalyticActivity: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoA
UniProtKB/Swiss-Prot Function: Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
UniProtKB/Swiss-Prot Induction: Up-regulated by 4-hydroxy-tamoxifen.

Enzyme Numbers (IUBMB) for SCP2 Gene

Gene Ontology (GO) - Molecular Function for SCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IDA 18465878
GO:0003824 catalytic activity --
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity --
GO:0005102 receptor binding IPI 20178365
GO:0005515 protein binding IPI 15182174
genes like me logo Genes that share ontologies with SCP2: view
genes like me logo Genes that share phenotypes with SCP2: view

Animal Models for SCP2 Gene

MGI Knock Outs for SCP2:

miRNA for SCP2 Gene

miRTarBase miRNAs that target SCP2

No data available for Transcription Factor Targeting and HOMER Transcription for SCP2 Gene

Localization for SCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCP2 Gene

Cytoplasm. Mitochondrion. Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues.
Isoform SCPx: Peroxisome. Note=Interaction with PEX5 is essential for peroxisomal import.
Isoform SCP2: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCP2 Gene COMPARTMENTS Subcellular localization image for SCP2 gene
Compartment Confidence
mitochondrion 5
peroxisome 5
nucleus 4
cytosol 2
endoplasmic reticulum 2
plasma membrane 2
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IDA 1347505
genes like me logo Genes that share ontologies with SCP2: view

Pathways for SCP2 Gene

genes like me logo Genes that share pathways with SCP2: view

Gene Ontology (GO) - Biological Process for SCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process --
GO:0006694 steroid biosynthetic process IDA 1703300
GO:0006699 bile acid biosynthetic process TAS --
GO:0006701 progesterone biosynthetic process IDA 1703300
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with SCP2: view

Compounds for SCP2 Gene

(1) HMDB Compounds for SCP2 Gene

Compound Synonyms Cas Number PubMed IDs
7-Dehydrocholesterol
  • (-)-7-dehydrocholesterol
434-16-2

(26) Novoseek inferred chemical compound relationships for SCP2 Gene

Compound -log(P) Hits PubMed IDs
sterol 92.3 192
dehydroergosterol 78 4
3-oxoacyl-coa 75 1
pristanic acid 74.8 1
allergens 69.8 13
genes like me logo Genes that share compounds with SCP2: view

Transcripts for SCP2 Gene

Unigene Clusters for SCP2 Gene

Sterol carrier protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: - - - -
SP6: -

Relevant External Links for SCP2 Gene

GeneLoc Exon Structure for
SCP2
ECgene alternative splicing isoforms for
SCP2

Expression for SCP2 Gene

mRNA expression in normal human tissues for SCP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCP2 Gene

This gene is overexpressed in Liver (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCP2 Gene

SOURCE GeneReport for Unigene cluster for SCP2 Gene Hs.476365

mRNA Expression by UniProt/SwissProt for SCP2 Gene

P22307-NLTP_HUMAN
Tissue specificity: Liver, fibroblasts, and placenta
genes like me logo Genes that share expressions with SCP2: view

Orthologs for SCP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SCP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCP2 36
  • 99.7 (n)
  • 99.63 (a)
SCP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCP2 36
  • 90.02 (n)
  • 87.57 (a)
SCP2 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCP2 36
  • 90.42 (n)
  • 88.43 (a)
SCP2 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scp2 36
  • 86.05 (n)
  • 89.21 (a)
Scp2 16
Scp2 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCP2 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCP2 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scp2 36
  • 84.46 (n)
  • 86.47 (a)
chicken
(Gallus gallus)
Aves SCP2 36
  • 74.78 (n)
  • 79.24 (a)
SCP2 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCP2 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24309 36
tropical clawed frog
(Silurana tropicalis)
Amphibia scp2 36
  • 72.19 (n)
  • 79.28 (a)
Str.17130 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4325 36
zebrafish
(Danio rerio)
Actinopterygii scp2a 36
  • 70.22 (n)
  • 76.59 (a)
scp2a 37
  • 75 (a)
OneToOne
zgc77634 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007921 36
  • 56.65 (n)
  • 58.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17597 37
  • 61 (a)
OneToMany
ScpX 36
  • 58.48 (n)
  • 59.62 (a)
ScpX 37
  • 58 (a)
OneToMany
CG17597 38
  • 63 (a)
ScpX 38
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea daf-22 36
  • 59.8 (n)
  • 59.06 (a)
daf-22 37
  • 55 (a)
OneToOne
Y57A10C.6 38
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FOX2 37
  • 9 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03372 36
  • 56.15 (n)
  • 55.73 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2009 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 61 (a)
OneToMany
CSA.3842 37
  • 60 (a)
OneToMany
Species with no ortholog for SCP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCP2 Gene

ENSEMBL:
Gene Tree for SCP2 (if available)
TreeFam:
Gene Tree for SCP2 (if available)

Paralogs for SCP2 Gene

Paralogs for SCP2 Gene

Pseudogenes.org Pseudogenes for SCP2 Gene

genes like me logo Genes that share paralogs with SCP2: view

Variants for SCP2 Gene

Sequence variations from dbSNP and Humsavar for SCP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8871 -- 53,051,327(+) TCCTT(A/C)TTGAA utr-variant-3-prime
rs13496 -- 53,051,070(+) ATTCA(A/G)TTTAA utr-variant-3-prime
rs768333 -- 52,931,821(-) TTTTC(C/T)TTAGT intron-variant
rs959691 -- 52,931,711(-) aaagc(C/T)tgaag intron-variant
rs1049891 -- 53,051,357(+) AAAAC(A/C)CCATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SCP2 Gene

Variant ID Type Subtype PubMed ID
nsv870582 CNV Gain 21882294
nsv870668 CNV Loss 21882294
esv2669916 CNV Deletion 23128226
nsv870947 CNV Loss 21882294
nsv10150 CNV Gain 18304495
nsv441693 CNV CNV 18776908
dgv51e1 CNV Complex 17122850
nsv514927 CNV Complex 21397061
dgv36n67 CNV Loss 20364138
nsv522862 CNV Loss 19592680
essv13816 CNV CNV 17122850

Relevant External Links for SCP2 Gene

HapMap Linkage Disequilibrium report
SCP2
Human Gene Mutation Database (HGMD)
SCP2

Disorders for SCP2 Gene

(1) OMIM Diseases for SCP2 Gene (184755)

UniProtKB/Swiss-Prot

NLTP_HUMAN
  • Leukoencephalopathy, with dystonia and motor neuropathy (LDMN) [MIM:613724]: A syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine. {ECO:0000269 PubMed:16685654}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(9) Novoseek inferred disease relationships for SCP2 Gene

Disease -log(P) Hits PubMed IDs
rhizomelic chondrodysplasia punctata, type 1 82.6 2
d-bifunctional protein deficiency 75.4 2
zellweger syndrome 74.9 5
adrenoleukodystrophy neonatal 69.3 1
allergy 56.9 5

Relevant External Links for SCP2

Genetic Association Database (GAD)
SCP2
Human Genome Epidemiology (HuGE) Navigator
SCP2
genes like me logo Genes that share disorders with SCP2: view

Publications for SCP2 Gene

  1. Cloning and expression of a cDNA encoding human sterol carrier protein 2. (PMID: 1703300) Yamamoto R. … Strauss J.F. III (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23
  2. cDNAs encoding members of a family of proteins related to human sterol carrier protein 2 and assignment of the gene to human chromosome 1 p21-pter. (PMID: 1718316) He Z. … Strauss J.F. III (DNA Cell Biol. 1991) 2 3 4 23
  3. Localization of human sterol carrier protein 2 gene and cDNA expression in COS-7 cell. (PMID: 1483685) Yamamoto R. (Hokkaido Igaku Zasshi 1992) 3 4 23
  4. The structure of the human sterol carrier protein X/sterol carrier protein 2 gene (SCP2). (PMID: 7698762) Ohba T. … Strauss J.F. III (Genomics 1994) 3 4 23
  5. NMR determination of the secondary structure and the three- dimensional polypeptide backbone fold of the human sterol carrier protein 2. (PMID: 8243660) Szyperski T. … Wuethrich K. (FEBS Lett. 1993) 3 4 23

Products for SCP2 Gene

  • Addgene plasmids for SCP2

Sources for SCP2 Gene

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