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Aliases for SCOC Gene

Aliases for SCOC Gene

  • Short Coiled-Coil Protein 2 3 5
  • SCOCO 3 4
  • Short Coiled Coil Protein 2
  • HRIHFB2072 3
  • UNC-69 3

External Ids for SCOC Gene

Previous GeneCards Identifiers for SCOC Gene

  • GC04P141490
  • GC04P141644
  • GC04P141756
  • GC04P141536
  • GC04P141178
  • GC04P136908

Summaries for SCOC Gene

Entrez Gene Summary for SCOC Gene

  • This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for SCOC Gene

SCOC (Short Coiled-Coil Protein) is a Protein Coding gene. Among its related pathways are Retrograde transport at the Trans-Golgi-Network and Golgi-to-ER retrograde transport.

UniProtKB/Swiss-Prot for SCOC Gene

  • Positive regulator of amino acid starvation-induced autophagy.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCOC Gene

Genomics for SCOC Gene

Regulatory Elements for SCOC Gene

Enhancers for SCOC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G140295 1.4 FANTOM5 Ensembl ENCODE 13.3 +39.2 39223 2.0 ZFP64 FEZF1 EGR1 ZNF366 FOS EGR2 YY2 USF2 CEBPB ZEB2 SCOC UCP1 MAML3 NDUFB4P9
GH04G139733 1.5 FANTOM5 Ensembl ENCODE 11.3 -522.2 -522164 4.2 PKNOX1 FEZF1 ZBTB40 RAD21 ZNF654 CEBPB ZEB2 REST SMARCA4 IKZF1 SCOC MAML3 GC04P139731 RN7SKP253
GH04G139871 1.3 FANTOM5 Ensembl ENCODE 10.5 -384.5 -384504 2.4 ELF3 SAP130 JUN CEBPG RAD21 RARA FOS ZNF652 HOMEZ GATAD2A MAML3 SCOC GC04M139789 LOC105377452
GH04G139738 1.2 Ensembl ENCODE 11.3 -517.0 -516968 3.5 FOXA2 ATF1 MLX FEZF1 YY1 FOS PAF1 SP5 NFYC REST SCOC GC04P139731 RN7SKP253
GH04G139690 1.2 Ensembl ENCODE 10.1 -565.4 -565355 2.4 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 PPARG SCOC H3F3AP6 GC04M139686 RN7SKP237
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCOC on UCSC Golden Path with GeneCards custom track

Genomic Location for SCOC Gene

140,257,286 bp from pter
140,385,726 bp from pter
128,441 bases
Plus strand

Genomic View for SCOC Gene

Genes around SCOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCOC Gene

Proteins for SCOC Gene

  • Protein details for SCOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Short coiled-coil protein
    Protein Accession:
    Secondary Accessions:
    • B7WPH7
    • D3DNY7
    • E9PB65
    • Q6P5T9
    • Q7L2Y0
    • Q7Z4P2
    • Q96JY9
    • Q9BZB2

    Protein attributes for SCOC Gene

    159 amino acids
    Molecular mass:
    18045 Da
    Quaternary structure:
    • Homodimer (PubMed:24098481). Interacts with ARL1, ARL2 and ARL3 (PubMed:11303027). Directly interacts with FEZ1 and UVRAG (PubMed:22354037, PubMed:24098481). The interaction with UVRAG is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. Interacts with NRBF2 (PubMed:22354037).
    • Sequence=AAK01707.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP97732.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SCOC Gene

    Alternative splice isoforms for SCOC Gene


neXtProt entry for SCOC Gene

Post-translational modifications for SCOC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCOC Gene

Domains & Families for SCOC Gene

Protein Domains for SCOC Gene


Suggested Antigen Peptide Sequences for SCOC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SCOC family.
  • Belongs to the SCOC family.
genes like me logo Genes that share domains with SCOC: view

No data available for Gene Families for SCOC Gene

Function for SCOC Gene

Molecular function for SCOC Gene

UniProtKB/Swiss-Prot Function:
Positive regulator of amino acid starvation-induced autophagy.

Gene Ontology (GO) - Molecular Function for SCOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with SCOC: view
genes like me logo Genes that share phenotypes with SCOC: view

Animal Model Products

CRISPR Products

miRNA for SCOC Gene

Clone Products

  • Applied Biological Materials Clones for SCOC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCOC Gene

Localization for SCOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCOC Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network. Cytoplasm, cytosol.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCOC gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for SCOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005768 colocalizes_with endosome IDA 22354037
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with SCOC: view

Pathways & Interactions for SCOC Gene

genes like me logo Genes that share pathways with SCOC: view

Gene Ontology (GO) - Biological Process for SCOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016239 positive regulation of macroautophagy IDA 22354037
GO:0061635 regulation of protein complex stability IMP 22354037
genes like me logo Genes that share ontologies with SCOC: view

No data available for SIGNOR curated interactions for SCOC Gene

Drugs & Compounds for SCOC Gene

No Compound Related Data Available

Transcripts for SCOC Gene

Unigene Clusters for SCOC Gene

Short coiled-coil protein:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for SCOC

Alternative Splicing Database (ASD) splice patterns (SP) for SCOC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - - - - - - -
SP8: - -

Relevant External Links for SCOC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCOC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCOC Gene

This gene is overexpressed in Salivary gland (12.9), Heart (10.9), Amniocyte (8.9), and Ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCOC Gene

NURSA nuclear receptor signaling pathways regulating expression of SCOC Gene:


SOURCE GeneReport for Unigene cluster for SCOC Gene:


mRNA Expression by UniProt/SwissProt for SCOC Gene:

Tissue specificity: Widely expressed with highest levels in brain, heart and skeletal muscle.

Evidence on tissue expression from TISSUES for SCOC Gene

  • Nervous system(5)
  • Lung(4.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with SCOC: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCOC Gene

Orthologs for SCOC Gene

This gene was present in the common ancestor of animals.

Orthologs for SCOC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100296832 34
  • 94.95 (n)
  • 84 (a)
(Canis familiaris)
Mammalia SCOC 34 35
  • 94.26 (n)
(Mus musculus)
Mammalia Scoc 34 16 35
  • 88.8 (n)
(Rattus norvegicus)
Mammalia Scoc 34
  • 87.98 (n)
(Pan troglodytes)
Mammalia SCOC 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia SCOC 35
  • 79 (a)
(Monodelphis domestica)
Mammalia SCOC 35
  • 74 (a)
(Gallus gallus)
Aves BERT 35
  • 99 (a)
(Anolis carolinensis)
Reptilia SCOC 35
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scoc 34
  • 67.54 (n)
Str.7270 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8663 34
(Danio rerio)
Actinopterygii scocb 35
  • 95 (a)
scoca 34 35
  • 69.32 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10458 34
fruit fly
(Drosophila melanogaster)
Insecta CG5934 35
  • 44 (a)
(Caenorhabditis elegans)
Secernentea unc-69 35
  • 29 (a)
Species where no ortholog for SCOC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCOC Gene

Gene Tree for SCOC (if available)
Gene Tree for SCOC (if available)

Paralogs for SCOC Gene Pseudogenes for SCOC Gene

genes like me logo Genes that share paralogs with SCOC: view

No data available for Paralogs for SCOC Gene

Variants for SCOC Gene

Sequence variations from dbSNP and Humsavar for SCOC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000005162 -- 140,294,676(+) GCCAC(-/TA)TGTTT intron-variant
rs1000012045 -- 140,340,602(+) CAAAA(G/T)AAATC intron-variant
rs1000045911 -- 140,296,018(+) TCACA(C/G)ACCTA intron-variant
rs1000064272 -- 140,287,944(+) TGTGG(A/G)CACAT intron-variant
rs1000078209 -- 140,341,822(+) GAAAA(C/T)TAAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SCOC Gene

Variant ID Type Subtype PubMed ID
dgv2912n106 CNV duplication 24896259
dgv3087e59 CNV duplication 20981092
esv1182482 CNV insertion 17803354
esv2668516 CNV deletion 23128226
esv2728435 CNV deletion 23290073
esv2728436 CNV deletion 23290073
esv3564722 CNV deletion 23714750
esv3602451 CNV loss 21293372
nsv1074757 CNV deletion 25765185
nsv1077973 CNV duplication 25765185
nsv1123850 CNV deletion 24896259
nsv1146992 CNV deletion 26484159
nsv1154121 CNV duplication 26484159

Variation tolerance for SCOC Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCOC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCOC Gene

Disorders for SCOC Gene

Relevant External Links for SCOC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCOC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCOC Gene

Publications for SCOC Gene

  1. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PMID: 11303027) Van Valkenburgh H. … Kahn R.A. (J. Biol. Chem. 2001) 2 3 4 64
  2. Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation. (PMID: 24098481) Behrens C. … KA1hnel K. (PLoS ONE 2013) 3 4 64
  3. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight N.C. … Tooze S.A. (EMBO J. 2012) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SCOC Gene

Sources for SCOC Gene

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