Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SCOC Gene

protein-coding   GIFtS: 48
GCID: GC04P141178

Short Coiled-Coil Protein

(Previous name: short coiled coil protein)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Short Coiled-Coil Protein1 2
Short Coiled Coil Protein1 2
SCOCO2 3

External Ids:    HGNC: 203351   Entrez Gene: 605922   Ensembl: ENSG000001531307   UniProtKB: Q9UIL13   

Export aliases for SCOC gene to outside databases

Previous GC identifers: GC04P141490 GC04P141644 GC04P141756 GC04P141536 GC04P136908


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SCOC Gene:
This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The
encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on
chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Apr
2009)

GeneCards Summary for SCOC Gene:
SCOC (short coiled-coil protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: SCOC_HUMAN, Q9UIL1
Function: Positive regulator of amino acid starvation-induced autophagy




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCOC gene promoter:
         CREB   AREB6   NF-1   POU2F1   POU2F1a   Bach2   SEF-1 (1)   AP-4   Cdc5   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SCOC promoter sequence
   Search Chromatin IP Primers for SCOC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCOC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.1   Ensembl cytogenetic band:  4q31.1   HGNC cytogenetic band: 4q28.3

SCOC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCOC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P141178:  view genomic region     (about GC identifiers)

Start:
141,178,440 bp from pter      End:
141,306,880 bp from pter
Size:
128,441 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SCOC_HUMAN, Q9UIL1 (See protein sequence)
Recommended Name: Short coiled-coil protein  
Size: 159 amino acids; 18045 Da
Subunit: Interacts with ARL1, ARL2 and ARL3. Directly interacts with FEZ1 and UVRAG. The interaction with UVRAG is
reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. Interacts with NRBF2
Sequence caution: Sequence=AAK01707.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAP97732.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for SCOC:
4BWD (3D)    
Secondary accessions: B7WPH7 D3DNY7 E9PB65 Q6P5T9 Q7L2Y0 Q7Z4P2 Q96JY9 Q9BZB2
Alternative splicing: 4 isoforms:  Q9UIL1-1   Q9UIL1-2   Q9UIL1-3   Q9UIL1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCOC: NX_Q9UIL1

Explore proteomics data for SCOC at MOPED


See SCOC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (8 alternative transcripts): 
NP_001146918.1  NP_001146956.1  NP_001147024.1  NP_001147057.1  NP_001147107.1  NP_001147135.1  NP_001147162.1  NP_115936.2  

ENSEMBL proteins: 
 ENSP00000377755   ENSP00000345262   ENSP00000426810   ENSP00000424605   ENSP00000477352  
 ENSP00000426649   ENSP00000377751   ENSP00000424688   ENSP00000421355   ENSP00000377753  

SCOC Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Proteins for SCOC
OriGene Protein Over-expression Lysate for SCOC
OriGene MassSpec for SCOC
OriGene Custom Protein Services for SCOC
GenScript Custom Purified and Recombinant Proteins Services for SCOC
Novus Biologicals SCOC Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for SCOC

 
Search eBioscience for Proteins for SCOC 

 
Search antibodies-online for proteins for SCOC 

 
Search antibodies-online for peptides for SCOC

SCOC Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for SCOC
OriGene Custom Antibody Services for SCOC
Novus Biologicals SCOC Antibody
Abcam antibodies for SCOC
Cloud-Clone Corp. Antibodies for SCOC
Search ThermoFisher Antibodies for SCOC
antibodies-online antibodies for SCOC (3 products) 

SCOC Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for SCOC
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SCOC
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for SCOC
Cloud-Clone Corp. CLIAs for SCOC
Search eBioscience for ELISAs for SCOC 
antibodies-online kits for SCOC (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
1 InterPro protein domain:
 IPR019357 DUF2205_coiled-coil

Graphical View of Domain Structure for InterPro Entry Q9UIL1

ProtoNet protein and cluster: Q9UIL1

UniProtKB/Swiss-Prot: SCOC_HUMAN, Q9UIL1
Similarity: Belongs to the SCOC family


Find genes that share domains with SCOC           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SCOC_HUMAN, Q9UIL1
Function: Positive regulator of amino acid starvation-induced autophagy

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
     
Find genes that share ontologies with SCOC           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for SCOC:
 Increased gamma-H2AX phosphory 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for SCOC

miRNA
Products:
    
miRTarBase miRNAs that target SCOC:
hsa-mir-424-5p (MIRT042453)

Block miRNA regulation of human, mouse, rat SCOC using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SCOC (see all 21):
hsa-miR-320a hsa-miR-142-5p hsa-miR-429 hsa-miR-376b hsa-miR-15a hsa-miR-507 hsa-miR-424 hsa-miR-133a
SwitchGear 3'UTR luciferase reporter plasmidSCOC 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for SCOC
Predesigned siRNA for gene silencing in human, mouse, rat SCOC

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SCOC

Clone
Products:
     
OriGene clones in human, mouse for SCOC (see all 44)
OriGene ORF clones in mouse, rat for SCOC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 8): SCOC (NM_001153635)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCOC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCOC

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for SCOC
Browse ESI BIO Cell Lines and PureStem Progenitors for SCOC 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCOC


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
SCOC_HUMAN, Q9UIL1: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus,
trans-Golgi network. Cytoplasm, cytosol
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol5
golgi apparatus5
nucleus3
extracellular1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane IEA--
GO:0005768colocalizes with endosome IDA--
GO:0005802colocalizes with trans-Golgi network IDA--
GO:0005829cytosol IEA--

Find genes that share ontologies with SCOC           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCOC
Interactions:

    GeneGlobe Interaction Network for SCOC

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

Selected Interacting proteins for SCOC (Q9UIL11, 2, 3 ENSP000003452624) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
FEZ1Q996892, 3, ENSP000002789194MINT-8398570 I2D: score=2 STRING: ENSP00000278919
SCHIP1Q9P0W51, 3EBI-2686537,EBI-1397509 I2D: score=1 
ARL1P406163, ENSP000002616364I2D: score=1 STRING: ENSP00000261636
FEZ2Q9UHY83, ENSP000003685474I2D: score=1 STRING: ENSP00000368547
ETS1P149213I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016239positive regulation of macroautophagy IDA--

Find genes that share ontologies with SCOC           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SCOC



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for SCOC gene (8 alternative transcripts): 
NM_001153446.1  NM_001153484.1  NM_001153552.1  NM_001153585.1  NM_001153635.1  NM_001153663.1  NM_001153690.1  NM_032547.2  

Unigene Cluster for SCOC:

Short coiled-coil protein
Hs.480815  [show with all ESTs]
Unigene Representative Sequence: AK092794
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000394205(uc003iib.2) ENST00000338517(uc011che.1 uc003iid.2)
ENST00000506322 ENST00000512749 ENST00000608372 ENST00000506597 ENST00000394201(uc003iif.2 uc011chh.1 uc003iig.2)
ENST00000510586 ENST00000502535 ENST00000394203(uc011chf.1 uc011chg.1)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat SCOC using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SCOC (see all 21):
hsa-miR-320a hsa-miR-142-5p hsa-miR-429 hsa-miR-376b hsa-miR-15a hsa-miR-507 hsa-miR-424 hsa-miR-133a
SwitchGear 3'UTR luciferase reporter plasmidSCOC 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SCOC
Predesigned siRNA for gene silencing in human, mouse, rat SCOC
Clone
Products:
     
OriGene clones in human, mouse for SCOC (see all 44)
OriGene ORF clones in mouse, rat for SCOC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 8): SCOC (NM_001153635)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCOC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCOC
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SCOC
OriGene qSTAR qPCR primer pairs in human, mouse for SCOC
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCOC
  QuantiTect SYBR Green Assays in human, mouse, rat SCOC
  QuantiFast Probe-based Assays in human, mouse, rat SCOC

Additional mRNA sequence: 

AB015335.1 AF330205.1 AF448857.1 AK027797.1 AK092794.1 AL133580.1 BC016511.1 BC062684.1 

Selected DOTS entries (see all 25):

DT.444169  DT.100883960  DT.100883963  DT.100883955  DT.100763222  DT.95357783  DT.100883957  DT.100883964 
DT.95357773  DT.95357774  DT.100692425  DT.95152511  DT.100842920  DT.100883956  DT.121226316  DT.121226325 
DT.121226381  DT.92462389  DT.92462407  DT.99946907  DT.100883959  DT.100883962  DT.121226352  DT.121226358 

Selected AceView cDNA sequences (see all 442):

CR599465 BU784835 BP376271 BM982833 AW235970 AA604634 BC062684 BU684889 
BU608814 BM458004 BX402332 BG151522 BP352680 BX429436 CR611757 AA890260 
BX341848 BU620183 CR597979 CR595594 BQ434604 BM730074 AI473201 BX408465 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SCOC (see all 9)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1:                                -     -     -     -     -                                                               
SP2:                          -     -     -     -     -     -                                                               
SP3:                          -     -     -     -     -     -                                                               
SP4:                                                  -     -                                                               
SP5:                                                        -                                                               


ECgene alternative splicing isoforms for SCOC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

SCOC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAATAATCTT
SCOC Expression
About this image


SCOC expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Limb (Muscoskeletal System)
         Limb Bud
SCOC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SCOC Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.480815

UniProtKB/Swiss-Prot: SCOC_HUMAN, Q9UIL1
Tissue specificity: Widely expressed with highest levels in brain, heart and skeletal muscle

    Custom PCR Arrays for SCOC
Primer
Products:
OriGene qPCR primer pairs and template standards for SCOC
OriGene qSTAR qPCR primer pairs in human, mouse for SCOC
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCOC
QuantiTect SYBR Green Assays in human, mouse, rat SCOC
QuantiFast Probe-based Assays in human, mouse, rat SCOC
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCOC

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for SCOC gene from Selected species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Scoc1 , 5 short coiled-coil protein1, 5 88.8(n)1
87.7(a)1
  8 (40.22 cM)5
563671  NM_001039137.31  NP_001034226.11 
 834344935 
chicken
(Gallus gallus)
Aves BERT6
short coiled-coil protein A
99(a)
1 ↔ 1
4(29092843-29099436)
lizard
(Anolis carolinensis)
Reptilia SCOC6
short coiled-coil protein
96(a)
1 ↔ 1
5(119789568-119791339)
African clawed frog
(Xenopus laevis)
Amphibia Xl.86632 Xenopus laevis transcribed sequence with strong similarity more 79.92(n)    48054876 
zebrafish
(Danio rerio)
Actinopterygii scoca1 short coiled-coil protein a 69.32(n)
78.76(a)
  562638  NM_001077559.1  NP_001071027.1 
fruit fly
(Drosophila melanogaster)
Insecta CG59346
--
44(a)
1 ↔ 1
3R(23099428-23100287)
worm
(Caenorhabditis elegans)
Secernentea unc-696
Protein UNC-69, isoform c
29(a)
1 ↔ 1
III(10318984-10320024) WBGene00006802


ENSEMBL Gene Tree for SCOC (if available)
TreeFam Gene Tree for SCOC (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for SCOC gene

Find genes that share paralogs with SCOC           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for SCOC
PGOHUM00000248193 PGOHUM00000244997


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for SCOC (see all 615)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1142511701,2
C,F--141176512(+) AGCTGT/CGATTT 1 -- us2k11Minor allele frequency- C:0.06WA 118
rs715843641,2
C--141176522(+) TGGCC-/T/TT  
        
TTTTT
1 -- us2k11NA 2
rs357735171,2
C--141176538(+) TTTTT-/T/TT  
        
GACAG
1 -- us2k11NA 2
rs1862760801,2
--141176552(+) TCTCAC/TTGTGT 1 -- us2k10--------
rs1433337371,2
--141176656(+) GGCCCA/GTTTTT 1 -- us2k10--------
rs1164842801,2
C,F--141176682(+) GGTTAC/TACTTC 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs1907894921,2
C--141176687(+) CACTTC/GAAGGG 1 -- us2k10--------
rs1158112671,2
F--141176751(+) CACATC/TATGTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs1822629921,2
--141176918(+) AGTAGA/GAAGTG 1 -- us2k10--------
rs1860314581,2
--141176987(+) AGCCAA/CCAAAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SCOC (141178440 - 141306880 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SCOC:    About this table    
Variant IDTypeSubtypePubMed ID
esv2728435CNV Deletion23290073
esv2668516CNV Deletion23128226
esv2728436CNV Deletion23290073
esv1182482CNV Insertion17803354

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SCOC
DNA2.0 Custom Variant and Variant Library Synthesis for SCOC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

Find genes that share disorders with SCOC           About GenesLikeMe

Genetic Association Database (GAD): SCOC
Human Genome Epidemiology (HuGE) Navigator: SCOC (1 document)

Export disorders for SCOC gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for SCOC gene, integrated from 10 sources (see all 18):
(articles sorted by number of sources associating them with SCOC)
    Utopia: connect your pdf to the dynamic
world of online information

  1. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PubMed id 11303027)1, 2, 3 Van Valkenburgh H.... Kahn R.A. (J. Biol. Chem. 2001)
  2. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PubMed id 22354037)1, 2 McKnight N.C.... Tooze S.A. (EMBO J. 2012)
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  6. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (PLoS ONE 2012)
  7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
  8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
  10. A comprehensive resource of interacting protein regions for refining human transcription factor networks. (PubMed id 20195357)1 Miyamoto-Sato E....Yanagawa H. (PLoS ONE 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 60592 HGNC: 20335 AceView: SCOC Ensembl:ENSG00000153130 euGenes: HUgn60592
ECgene: SCOC H-InvDB: SCOC

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for SCOC Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for SCOC gene:
Search GeneIP for patents involving SCOC

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for SCOC   OriGene RNAi products in human, mouse, rat for SCOC  
 OriGene qPCR primer pairs and template standards for SCOC   OriGene Protein Over-expression Lysate for SCOC  
 OriGene MassSpec for SCOC   OriGene clones in human, mouse for SCOC  
 OriGene qSTAR qPCR primer pairs in human, mouse for SCOC   OriGene Purified Protein for SCOC  
 OriGene ORF clones in mouse, rat for SCOC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for SCOC   OriGene Custom Protein Services for SCOC  

 
 
 Block miRNA regulation of human, mouse, rat SCOC using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SCOC
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCOC Predesigned siRNA for gene silencing in human, mouse, rat SCOC
 QuantiFast Probe-based Assays in human, mouse, rat SCOC QuantiTect SYBR Green Assays in human, mouse, rat SCOC
 Custom PCR Arrays for SCOC Search Chromatin IP Primers for SCOC
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCOC  GeneGlobe Interaction Network for SCOC
 Regulatory tfbs in SCOC promoter
 GenScript Custom Purified and Recombinant Proteins Services for SCOC GenScript cDNA clones with any tag delivered in your preferred vector for SCOC
 GenScript Custom Assay Services for SCOC GenScript Custom overexpressing Cell Line Services for SCOC
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for SCOC
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 SCOC antibodies
 SCOC lysates
 Antibodies for SCOC
 See all of Abcam's Antibodies, Kits and Proteins for SCOC
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for SCOC
 Antibodies for SCOC
 ELISAs for SCOC
 CLIAs for SCOC



 Browse ESI BIO Cell Lines and PureStem Progenitors for SCOC
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCOC
 SwitchGear 3'UTR luciferase reporter plasmids for SCOC
 SwitchGear Promoter luciferase reporter plasmids for SCOC
 Search ThermoFisher Antibodies for SCOC
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCOC
 Browse compounds at ApexBio
 Search Addgene for plasmids for SCOC
  Search eBioscience for proteins for SCOC
  Search eBioscience for elisas for SCOC
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for SCOC
 antibodies-online antibodies for SCOC (3 products)
 antibodies-online kits for SCOC (6 products)
  Search antibodies-online for peptides for SCOC
  Search antibodies-online for proteins for SCOC
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      SCOC gene at Home site.
Version: 3.12.258 10 Dec 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4