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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCOC Gene

protein-coding   GIFtS: 48
GCID: GC04P141178

Short Coiled-Coil Protein

(Previous name: short coiled coil protein)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Short Coiled-Coil Protein1 2
Short Coiled Coil Protein1 2
SCOCO2 3

External Ids:    HGNC: 203351   Entrez Gene: 605922   Ensembl: ENSG000001531307   UniProtKB: Q9UIL13   

Export aliases for SCOC gene to outside databases

Previous GC identifers: GC04P141490 GC04P141644 GC04P141756 GC04P141536 GC04P136908


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCOC Gene:
This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The
encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on
chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Apr
2009)

GeneCards Summary for SCOC Gene: 
SCOC (short coiled-coil protein) is a protein-coding gene. Diseases associated with SCOC include keratoderma. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: SCOC_HUMAN, Q9UIL1
Function: Positive regulator of amino acid starvation-induced autophagy




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCOC gene promoter:
         CREB   AREB6   NF-1   POU2F1   POU2F1a   Bach2   SEF-1 (1)   AP-4   Cdc5   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SCOC promoter sequence
   Search SABiosciences Chromatin IP Primers for SCOC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCOC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.1   Ensembl cytogenetic band:  4q31.1   HGNC cytogenetic band: 4q28.3

SCOC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCOC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P141178:  view genomic region     (about GC identifiers)

Start:
141,178,440 bp from pter      End:
141,303,710 bp from pter
Size:
125,271 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SCOC_HUMAN, Q9UIL1 (See protein sequence)
Recommended Name: Short coiled-coil protein  
Size: 159 amino acids; 18045 Da
Subunit: Interacts with ARL1, ARL2 and ARL3. Directly interacts with FEZ1 and UVRAG. The interaction with UVRAG is
reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. Interacts with NRBF2
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus,
trans-Golgi network. Cytoplasm, cytosol
Sequence caution: Sequence=AAK01707.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAP97732.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B7WPH7 D3DNY7 E9PB65 Q6P5T9 Q7L2Y0 Q7Z4P2 Q96JY9 Q9BZB2
Alternative splicing: 4 isoforms:  Q9UIL1-1   Q9UIL1-2   Q9UIL1-3   Q9UIL1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCOC: NX_Q9UIL1

Explore proteomics data for SCOC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UIL1

  • SCOC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SCOC Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_001146918.1  NP_001146956.1  NP_001147024.1  NP_001147057.1  NP_001147107.1  NP_001147135.1  NP_001147162.1  NP_115936.2  

    ENSEMBL proteins: 
     ENSP00000377755   ENSP00000345262   ENSP00000426810   ENSP00000424605   ENSP00000377751  
     ENSP00000426649   ENSP00000424688   ENSP00000421355   ENSP00000377753  

    Human Recombinant Protein Products for SCOC: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins for SCOC
    OriGene Protein Over-expression Lysate for SCOC
    OriGene MassSpec for SCOC 
    OriGene Custom Protein Services for SCOC
    GenScript Custom Purified and Recombinant Proteins Services for SCOC
    Novus Biologicals SCOC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCOC 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005768colocalizes with endosome IDA--
    GO:0005802colocalizes with trans-Golgi network IDA--
    GO:0005829cytosol IEA--

    SCOC for ontologies           About GeneDecksing



    SCOC Antibody Products: 
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    Novus Biologicals SCOC Antibody
    Abcam antibodies for SCOC
    Cloud-Clone Corp. Antibodies for SCOC 
    Search ThermoFisher Antibodies for SCOC
    LSBio Antibodies in human, mouse, rat for SCOC 

    Assay Products for SCOC: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SCOC 
    Cloud-Clone Corp. CLIAs for SCOC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019357 DUF2205_coiled-coil

    Graphical View of Domain Structure for InterPro Entry Q9UIL1

    ProtoNet protein and cluster: Q9UIL1

    UniProtKB/Swiss-Prot: SCOC_HUMAN, Q9UIL1
    Similarity: Belongs to the SCOC family


    SCOC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCOC_HUMAN, Q9UIL1
    Function: Positive regulator of amino acid starvation-induced autophagy

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    SCOC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SCOC:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SCOC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCOC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCOC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCOC 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCOC
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SCOC (see all 21):
    hsa-miR-320a hsa-miR-142-5p hsa-miR-429 hsa-miR-376b hsa-miR-15a hsa-miR-507 hsa-miR-424 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidSCOC 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SCOC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCOC

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SCOC
    Sirion Biotech Customized adenovirus for overexpression of SCOC

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SCOC (see all 39)
    OriGene ORF clones in mouse, rat for SCOC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): SCOC (NM_001153635)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCOC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCOC
    Sirion Biotech Customized lentivirus for stable overexpression of SCOC 
                         Customized lentivirus expression plasmids for stable overexpression of SCOC 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SCOC
    Search LifeMap BioReagents cell lines for SCOC
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCOC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCOC

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/12 Interacting proteins for SCOC (Q9UIL11, 2, 3 ENSP000003452624) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FEZ1Q996892, 3, ENSP000002789194MINT-8398570 I2D: score=2 STRING: ENSP00000278919
    SCHIP1Q9P0W51, 3EBI-2686537,EBI-1397509 I2D: score=1 
    ARL1P406163, ENSP000002616364I2D: score=1 STRING: ENSP00000261636
    FEZ2Q9UHY83, ENSP000003685474I2D: score=1 STRING: ENSP00000368547
    ETS1P149213I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016239positive regulation of macroautophagy IDA--

    SCOC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCOC

    Search CenterWatch for drugs/clinical trials and news about SCOC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SCOC gene (8 alternative transcripts): 
    NM_001153446.1  NM_001153484.1  NM_001153552.1  NM_001153585.1  NM_001153635.1  NM_001153663.1  NM_001153690.1  NM_032547.2  

    Unigene Cluster for SCOC:

    Short coiled-coil protein
    Hs.480815  [show with all ESTs]
    Unigene Representative Sequence: AK092794
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394205(uc003iib.2) ENST00000338517(uc011che.1 uc003iid.2)
    ENST00000506322 ENST00000512749 ENST00000394201(uc003iif.2 uc011chh.1 uc003iig.2)
    ENST00000506597 ENST00000510586 ENST00000502535 ENST00000394203(uc011chf.1 uc011chg.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCOC
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SCOC (see all 21):
    hsa-miR-320a hsa-miR-142-5p hsa-miR-429 hsa-miR-376b hsa-miR-15a hsa-miR-507 hsa-miR-424 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidSCOC 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SCOC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCOC
    Clone
    Products:
         
    OriGene clones in human, mouse for SCOC (see all 39)
    OriGene ORF clones in mouse, rat for SCOC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): SCOC (NM_001153635)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCOC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCOC
    Sirion Biotech Customized lentivirus for stable overexpression of SCOC 
                         Customized lentivirus expression plasmids for stable overexpression of SCOC 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SCOC
    OriGene qSTAR qPCR primer pairs in human, mouse for SCOC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCOC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCOC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCOC

    Additional mRNA sequence: 

    AB015335.1 AF330205.1 AF448857.1 AK027797.1 AK092794.1 AL133580.1 BC016511.1 BC062684.1 

    24/25 DOTS entries (see all 25):

    DT.444169  DT.100883960  DT.100883963  DT.100883955  DT.100763222  DT.95357783  DT.100883957  DT.100883964 
    DT.95357773  DT.95357774  DT.100692425  DT.95152511  DT.100842920  DT.100883956  DT.121226316  DT.121226325 
    DT.121226381  DT.92462389  DT.92462407  DT.99946907  DT.100883959  DT.100883962  DT.121226352  DT.121226358 

    24/442 AceView cDNA sequences (see all 442):

    BQ777107 BU069784 BU686595 AI123498 BM541557 BM740998 BX352096 CR600463 
    CR605728 BQ718741 AI245588 AV733199 CB959531 AW235970 BX429436 CR611757 
    BM458004 BG151522 AI342758 BQ720093 AA890260 BU620183 BM671514 AL133580 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SCOC (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
    SP1:                                -     -     -     -     -                                                               
    SP2:                          -     -     -     -     -     -                                                               
    SP3:                          -     -     -     -     -     -                                                               
    SP4:                                                  -     -                                                               
    SP5:                                                        -                                                               


    ECgene alternative splicing isoforms for SCOC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCOC expression in normal human tissues (normalized intensities)      SCOC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATAATCTT
    SCOC Expression
    About this image


    SCOC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See SCOC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCOC

    SOURCE GeneReport for Unigene cluster: Hs.480815

    UniProtKB/Swiss-Prot: SCOC_HUMAN, Q9UIL1
    Tissue specificity: Widely expressed with highest levels in brain, heart and skeletal muscle

        SABiosciences Custom PCR Arrays for SCOC
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCOC
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCOC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCOC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SCOC gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scoc1 , 5 short coiled-coil protein1, 5 89.56(n)1
    91.92(a)1
      8 (40.22 cM)5
    563671  NM_001039137.21  NP_001034226.11 
     834344935 
    chicken
    (Gallus gallus)
    Aves SCOC1 short coiled-coil protein 88.21(n)
    98.78(a)
      422446  NM_001114852.1  NP_001108324.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCOC6
    Uncharacterized protein
    96(a)
    1 ↔ 1
    5(119789568-119791339)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.86632 Xenopus laevis transcribed sequence with strong similarity more 79.92(n)    48054876 
    zebrafish
    (Danio rerio)
    Actinopterygii scocb1 short coiled-coil protein b 74.43(n)
    95.89(a)
      791709  NM_001005966.1  NP_001005966.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG59346
    --
    42(a)
    1 ↔ 1
    3R(23099428-23100287)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-696
    Protein UNC-69, isoform c
    27(a)
    1 ↔ 1
    III(10318984-10320024)


    ENSEMBL Gene Tree for SCOC (if available)
    TreeFam Gene Tree for SCOC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCOC gene

    SCOC for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SCOC
    PGOHUM00000248193 PGOHUM00000244997


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/615 SNPs in SCOC are shown (see all 615)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1142511701,2
    C,F--141176512(+) AGCTGT/CGATTT 1 -- us2k11Minor allele frequency- C:0.06WA 118
    rs715843641,2
    C--141176522(+) TGGCC-/T/TT  
            
    TTTTT
    1 -- us2k11NA 2
    rs357735171,2
    C--141176538(+) TTTTT-/T/TT  
            
    GACAG
    1 -- us2k11NA 2
    rs1862760801,2
    --141176552(+) TCTCAC/TTGTGT 1 -- us2k10--------
    rs1433337371,2
    --141176656(+) GGCCCA/GTTTTT 1 -- us2k10--------
    rs1164842801,2
    C,F--141176682(+) GGTTAC/TACTTC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1907894921,2
    C--141176687(+) CACTTC/GAAGGG 1 -- us2k10--------
    rs1158112671,2
    F--141176751(+) CACATC/TATGTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1822629921,2
    --141176918(+) AGTAGA/GAAGTG 1 -- us2k10--------
    rs1860314581,2
    --141176987(+) AGCCAA/CCAAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SCOC (141178440 - 141303710 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SCOC:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2728435CNV Deletion23290073
    esv2668516CNV Deletion23128226
    esv2728436CNV Deletion23290073
    esv1182482CNV Insertion17803354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SCOC:    About MalaCards
    keratoderma    


    SCOC for disorders           About GeneDecksing

    Genetic Association Database (GAD): SCOC
    Human Genome Epidemiology (HuGE) Navigator: SCOC (1 document)

    Export disorders for SCOC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCOC gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with SCOC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PubMed id 11303027)1, 2, 3 Van Valkenburgh H.... Kahn R.A. (2001)
    2. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PubMed id 22354037)1, 2 McKnight N.C.... Tooze S.A. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A comprehensive resource of interacting protein region s for refining human transcription factor networks. (PubMed id 20195357)1 Miyamoto-Sato E....Yanagawa H. (2010)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 60592 HGNC: 20335 AceView: SCOC Ensembl:ENSG00000153130 euGenes: HUgn60592
    ECgene: SCOC H-InvDB: SCOC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCOC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCOC gene:
    Search GeneIP for patents involving SCOC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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