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Aliases for SCOC Gene

Aliases for SCOC Gene

  • Short Coiled-Coil Protein 2 3
  • Short Coiled Coil Protein 2 3
  • SCOCO 3 4
  • HRIHFB2072 3

External Ids for SCOC Gene

Previous GeneCards Identifiers for SCOC Gene

  • GC04P141490
  • GC04P141644
  • GC04P141756
  • GC04P141536
  • GC04P141178
  • GC04P136908

Summaries for SCOC Gene

Entrez Gene Summary for SCOC Gene

  • This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for SCOC Gene

SCOC (Short Coiled-Coil Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SCOC Gene

  • Positive regulator of amino acid starvation-induced autophagy.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCOC Gene

Genomics for SCOC Gene

Regulatory Elements for SCOC Gene

Genomic Location for SCOC Gene

140,257,286 bp from pter
140,385,726 bp from pter
128,441 bases
Plus strand

Genomic View for SCOC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCOC Gene

Proteins for SCOC Gene

  • Protein details for SCOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Short coiled-coil protein
    Protein Accession:
    Secondary Accessions:
    • B7WPH7
    • D3DNY7
    • E9PB65
    • Q6P5T9
    • Q7L2Y0
    • Q7Z4P2
    • Q96JY9
    • Q9BZB2

    Protein attributes for SCOC Gene

    159 amino acids
    Molecular mass:
    18045 Da
    Quaternary structure:
    • Interacts with ARL1, ARL2 and ARL3. Directly interacts with FEZ1 and UVRAG. The interaction with UVRAG is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. Interacts with NRBF2.
    • Sequence=AAK01707.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP97732.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SCOC Gene

    Alternative splice isoforms for SCOC Gene


neXtProt entry for SCOC Gene

Proteomics data for SCOC Gene at MOPED

Post-translational modifications for SCOC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCOC Gene

Domains for SCOC Gene

Protein Domains for SCOC Gene


Suggested Antigen Peptide Sequences for SCOC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UIL1
  • Belongs to the SCOC family.
genes like me logo Genes that share domains with SCOC: view

No data available for Gene Families for SCOC Gene

Function for SCOC Gene

Molecular function for SCOC Gene

UniProtKB/Swiss-Prot Function: Positive regulator of amino acid starvation-induced autophagy.

Gene Ontology (GO) - Molecular Function for SCOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with SCOC: view

Phenotypes for SCOC Gene

GenomeRNAi human phenotypes for SCOC:
genes like me logo Genes that share phenotypes with SCOC: view

miRNA for SCOC Gene

miRTarBase miRNAs that target SCOC

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCOC Gene

Localization for SCOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCOC Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network. Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for SCOC Gene COMPARTMENTS Subcellular localization image for SCOC gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for SCOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005768 colocalizes_with endosome IDA 22354037
GO:0005802 colocalizes_with trans-Golgi network IDA 22354037
GO:0005829 cytosol IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SCOC: view

Pathways for SCOC Gene

SuperPathways for SCOC Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016239 positive regulation of macroautophagy IDA 22354037
genes like me logo Genes that share ontologies with SCOC: view

No data available for Pathways by source for SCOC Gene

Transcripts for SCOC Gene

Unigene Clusters for SCOC Gene

Short coiled-coil protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCOC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - - - - - - -
SP8: - -

Relevant External Links for SCOC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCOC Gene

mRNA expression in normal human tissues for SCOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCOC Gene

SOURCE GeneReport for Unigene cluster for SCOC Gene Hs.480815

mRNA Expression by UniProt/SwissProt for SCOC Gene

Tissue specificity: Widely expressed with highest levels in brain, heart and skeletal muscle.
genes like me logo Genes that share expressions with SCOC: view

No data available for mRNA differential expression in normal tissues for SCOC Gene

Orthologs for SCOC Gene

This gene was present in the common ancestor of animals.

Orthologs for SCOC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCOC 36
  • 82 (a)
(Bos Taurus)
Mammalia LOC100296832 35
  • 94.95 (n)
  • 95.96 (a)
  • 84 (a)
(Canis familiaris)
Mammalia SCOC 35
  • 94.26 (n)
  • 95.08 (a)
  • 79 (a)
(Mus musculus)
Mammalia Scoc 35
  • 88.8 (n)
  • 87.7 (a)
Scoc 16
Scoc 36
  • 74 (a)
(Monodelphis domestica)
Mammalia SCOC 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia SCOC 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Scoc 35
  • 87.98 (n)
  • 85.25 (a)
(Gallus gallus)
Aves BERT 36
  • 99 (a)
(Anolis carolinensis)
Reptilia SCOC 36
  • 96 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8663 35
tropical clawed frog
(Silurana tropicalis)
Amphibia scoc 35
  • 67.54 (n)
  • 76.52 (a)
Str.7270 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10458 35
(Danio rerio)
Actinopterygii scoca 35
  • 69.32 (n)
  • 78.76 (a)
scoca 36
  • 66 (a)
scocb 36
  • 95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5934 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea unc-69 36
  • 29 (a)
Species with no ortholog for SCOC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCOC Gene

Gene Tree for SCOC (if available)
Gene Tree for SCOC (if available)

Paralogs for SCOC Gene Pseudogenes for SCOC Gene

genes like me logo Genes that share paralogs with SCOC: view

No data available for Paralogs for SCOC Gene

Variants for SCOC Gene

Sequence variations from dbSNP and Humsavar for SCOC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs358307 -- 140,376,297(+) GAATA(C/T)ATATT intron-variant
rs358308 -- 140,376,988(+) CTTAA(A/C)ATCAT intron-variant
rs358309 -- 140,377,192(+) TACAG(A/G)TGTGC intron-variant
rs358310 -- 140,377,455(+) GGGGA(A/C)AGATG intron-variant
rs358311 -- 140,377,555(+) ATTTC(A/G)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCOC Gene

Variant ID Type Subtype PubMed ID
esv2728435 CNV Deletion 23290073
esv2728436 CNV Deletion 23290073
esv2668516 CNV Deletion 23128226
esv1182482 CNV Insertion 17803354

Relevant External Links for SCOC Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCOC Gene

Disorders for SCOC Gene

Relevant External Links for SCOC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SCOC: view

No data available for UniProtKB/Swiss-Prot for SCOC Gene

Publications for SCOC Gene

  1. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PMID: 11303027) Van Valkenburgh H. … Kahn R.A. (J. Biol. Chem. 2001) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight N.C. … Tooze S.A. (EMBO J. 2012) 3 4
  5. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PMID: 22558309) Wong K.A. … O'Bryan J.P. (PLoS ONE 2012) 3

Products for SCOC Gene

Sources for SCOC Gene

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