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Aliases for SCOC Gene

Aliases for SCOC Gene

  • Short Coiled-Coil Protein 2 3 5
  • Short Coiled Coil Protein 2 3
  • SCOCO 3 4
  • HRIHFB2072 3
  • UNC-69 3

External Ids for SCOC Gene

Previous GeneCards Identifiers for SCOC Gene

  • GC04P141490
  • GC04P141644
  • GC04P141756
  • GC04P141536
  • GC04P141178
  • GC04P136908

Summaries for SCOC Gene

Entrez Gene Summary for SCOC Gene

  • This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for SCOC Gene

SCOC (Short Coiled-Coil Protein) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport.

UniProtKB/Swiss-Prot for SCOC Gene

  • Positive regulator of amino acid starvation-induced autophagy.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCOC Gene

Genomics for SCOC Gene

Regulatory Elements for SCOC Gene

Enhancers for SCOC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCOC on UCSC Golden Path with GeneCards custom track

Genomic Location for SCOC Gene

Chromosome:
4
Start:
140,257,286 bp from pter
End:
140,385,726 bp from pter
Size:
128,441 bases
Orientation:
Plus strand

Genomic View for SCOC Gene

Genes around SCOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCOC Gene

Proteins for SCOC Gene

  • Protein details for SCOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIL1-SCOC_HUMAN
    Recommended name:
    Short coiled-coil protein
    Protein Accession:
    Q9UIL1
    Secondary Accessions:
    • B7WPH7
    • D3DNY7
    • E9PB65
    • Q6P5T9
    • Q7L2Y0
    • Q7Z4P2
    • Q96JY9
    • Q9BZB2

    Protein attributes for SCOC Gene

    Size:
    159 amino acids
    Molecular mass:
    18045 Da
    Quaternary structure:
    • Interacts with ARL1, ARL2 and ARL3. Directly interacts with FEZ1 and UVRAG. The interaction with UVRAG is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. Interacts with NRBF2.
    SequenceCaution:
    • Sequence=AAK01707.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP97732.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SCOC Gene

    Alternative splice isoforms for SCOC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCOC Gene

Proteomics data for SCOC Gene at MOPED

Post-translational modifications for SCOC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCOC Gene

Domains & Families for SCOC Gene

Protein Domains for SCOC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCOC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIL1

UniProtKB/Swiss-Prot:

SCOC_HUMAN :
  • Belongs to the SCOC family.
Family:
  • Belongs to the SCOC family.
genes like me logo Genes that share domains with SCOC: view

No data available for Gene Families for SCOC Gene

Function for SCOC Gene

Molecular function for SCOC Gene

UniProtKB/Swiss-Prot Function:
Positive regulator of amino acid starvation-induced autophagy.
genes like me logo Genes that share phenotypes with SCOC: view

miRNA for SCOC Gene

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCOC Gene

Localization for SCOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCOC Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCOC Gene COMPARTMENTS Subcellular localization image for SCOC gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 3
extracellular 2

Gene Ontology (GO) - Cellular Components for SCOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 colocalizes_with endosome IDA 22354037
genes like me logo Genes that share ontologies with SCOC: view

Pathways & Interactions for SCOC Gene

genes like me logo Genes that share pathways with SCOC: view

Gene Ontology (GO) - Biological Process for SCOC Gene

None

No data available for SIGNOR curated interactions for SCOC Gene

Drugs & Compounds for SCOC Gene

No Compound Related Data Available

Transcripts for SCOC Gene

Unigene Clusters for SCOC Gene

Short coiled-coil protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCOC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - - - - - - -
SP8: - -
SP9:

Relevant External Links for SCOC Gene

GeneLoc Exon Structure for
SCOC
ECgene alternative splicing isoforms for
SCOC

Expression for SCOC Gene

mRNA expression in normal human tissues for SCOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCOC Gene

This gene is overexpressed in Salivary gland (12.9), Heart (10.9), Amniocyte (8.9), and Ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCOC Gene



SOURCE GeneReport for Unigene cluster for SCOC Gene Hs.480815

mRNA Expression by UniProt/SwissProt for SCOC Gene

Q9UIL1-SCOC_HUMAN
Tissue specificity: Widely expressed with highest levels in brain, heart and skeletal muscle.
genes like me logo Genes that share expression patterns with SCOC: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SCOC Gene

Orthologs for SCOC Gene

This gene was present in the common ancestor of animals.

Orthologs for SCOC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100296832 35
  • 94.95 (n)
  • 95.96 (a)
SCOC 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCOC 35
  • 94.26 (n)
  • 95.08 (a)
SCOC 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scoc 35
  • 88.8 (n)
  • 87.7 (a)
Scoc 16
Scoc 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scoc 35
  • 87.98 (n)
  • 85.25 (a)
oppossum
(Monodelphis domestica)
Mammalia SCOC 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCOC 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCOC 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves BERT 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCOC 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scoc 35
  • 67.54 (n)
  • 76.52 (a)
Str.7270 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8663 35
zebrafish
(Danio rerio)
Actinopterygii scoca 35
  • 69.32 (n)
  • 78.76 (a)
scoca 36
  • 66 (a)
OneToMany
scocb 36
  • 95 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10458 35
fruit fly
(Drosophila melanogaster)
Insecta CG5934 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-69 36
  • 29 (a)
OneToOne
Species with no ortholog for SCOC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCOC Gene

ENSEMBL:
Gene Tree for SCOC (if available)
TreeFam:
Gene Tree for SCOC (if available)

Paralogs for SCOC Gene

Pseudogenes.org Pseudogenes for SCOC Gene

genes like me logo Genes that share paralogs with SCOC: view

No data available for Paralogs for SCOC Gene

Variants for SCOC Gene

Sequence variations from dbSNP and Humsavar for SCOC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs358307 -- 140,376,297(+) GAATA(C/T)ATATT intron-variant
rs358308 -- 140,376,988(+) CTTAA(A/C)ATCAT intron-variant
rs358309 -- 140,377,192(+) TACAG(A/G)TGTGC intron-variant
rs358310 -- 140,377,455(+) GGGGA(A/C)AGATG intron-variant
rs358311 -- 140,377,555(+) ATTTC(A/G)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCOC Gene

Variant ID Type Subtype PubMed ID
esv2728435 CNV Deletion 23290073
esv2728436 CNV Deletion 23290073
esv2668516 CNV Deletion 23128226
esv1182482 CNV Insertion 17803354

Variation tolerance for SCOC Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SCOC Gene

Disorders for SCOC Gene

Relevant External Links for SCOC

Genetic Association Database (GAD)
SCOC
Human Genome Epidemiology (HuGE) Navigator
SCOC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCOC

No disorders were found for SCOC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCOC Gene

Publications for SCOC Gene

  1. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PMID: 11303027) Van Valkenburgh H. … Kahn R.A. (J. Biol. Chem. 2001) 2 3 4 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation. (PMID: 24098481) Behrens C. … KA1hnel K. (PLoS ONE 2013) 3

Products for SCOC Gene

Sources for SCOC Gene

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