SCO2 Gene
protein-coding GIFtS: 57
GCID: GC22M050961
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SCO2 cytochrome c oxidase assembly protein(Previous names: SCO (cytochrome oxidase deficient, yeast) homolog 2, SCO...)
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Aliases
for SCO2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SCO2 Cytochrome C Oxidase Assembly Protein1 2 | | Cytochrome Oxidase Deficient Homolog 22 | | SCO1L1 2 | | Protein SCO2 Homolog, Mitochondrial2 | | SCO (Cytochrome Oxidase Deficient, Yeast) Homolog 21 | | SCO Cytochrome Oxidase Deficient Homolog 22 | | SCO Cytochrome Oxidase Deficient Homolog 2 (Yeast)1 | | |
Export aliases for SCO2 gene to outside databasesPrevious GC identifers: GC22M047466 GC22M049094 GC22M049252 GC22M049308 GC22M033853 |
Summaries
for SCO2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SCO2:
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps tomaintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production.Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COXasembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidasesubunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy. (provided by RefSeq,Dec 2009)
UniProtKB/Swiss-Prot: SCO2_HUMAN, O43819Function: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II(COX2)
Gene Wiki entry for SCO2
|
Genomic Views
for SCO2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCO2 gene promoter:
PPAR-gamma1 Sp1 HTF PPAR-gamma2 Pax-4a Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCO2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCO2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.33 Ensembl cytogenetic band: 22q13.33 HGNC cytogenetic band: 22q13.33SCO2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M050961: view genomic region
(about GC identifiers)
Start:
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50,961,997 bp from pter |
End:
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50,964,868 bp from pter |
Size:
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2,872 bases |
Orientation:
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minus strand |
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Proteins
for SCO2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCO2_HUMAN, O43819 (See
protein sequence)Recommended Name: Protein SCO2 homolog, mitochondrial precursor Size: 266 amino acids; 29810 Da
Subcellular location: Mitochondrion
1 PDB 3D structure from  and Proteopedia  for SCO2:2RLI (3D)
Secondary accessions: Q3T1B5 Q9UK87Explore the universe of human proteins at neXtProt for SCO2: NX_O43819
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43819
SCO2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001162580.1 NP_001162581.1 NP_001162582.1 NP_005129.2
ENSEMBL proteins: ENSP00000379046 ENSP00000252785 ENSP00000415642 ENSP00000403570 ENSP00000444433 ENSP00000444242
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SCO2 for ontologies About GeneDecksing
SCO2 Antibody Products:
Assay Products for SCO2: |
Protein
Domains /
Families
for SCO2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCO2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43819ProtoNet protein and cluster: O43819 1 Blocks protein family: IPB003782 Electron transport protein SCO1/SenC
UniProtKB/Swiss-Prot: SCO2_HUMAN, O43819Similarity: Belongs to the SCO1/2 familySimilarity: Contains 1 thioredoxin domain |
Function
for SCO2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SCO2_HUMAN, O43819Function: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II(COX2) Genatlas biochemistry entry for SCO2:yeast SCO2 homolog,COX assembly gene,catalyzing the synthesis of cytochrome C oxidase 2,predominantly expressed inheart,skeletal muscle,also expressed in brain and kidney
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCO2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCO2 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): SCO2 (NM_005138) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCO2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCO2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
SCO2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Sco2tm1.1Easc for SCO2
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Sco2):
SCO2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SCO2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Pyrimidine metabolism | |
1  BioSystems Pathway for SCO2
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCO2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/11 Interacting proteins for SCO2 (O438192, 3 ENSP000002527854) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001701 | in utero embryonic development |
IEA | -- | | GO:0003012 | muscle system process |
IEA | -- | | GO:0006825 | copper ion transport |
IEA | -- | | GO:0006878 | cellular copper ion homeostasis |
IEA | -- | | GO:0008535 | respiratory chain complex IV assembly |
IEA | -- |
SCO2 for ontologies About GeneDecksing
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Drugs & Compounds
for SCO2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SCO2 for compounds About GeneDecksing
 Browse Tocris compounds for SCO2
1 HMDB Compound for SCO2 About this table
4 Novoseek chemical compound relationships for SCO2 gene About this table
Search CenterWatch for drugs/clinical trials and news about SCO2
|
Transcripts
for SCO2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCO2 gene (4 alternative transcripts): NM_001169109.1 NM_001169110.1 NM_001169111.1 NM_005138.2 6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000395693(uc003blz.4) ENST00000252785(uc003bma.3) ENST00000439934
ENST00000423348 ENST00000543927(uc021wsa.1) ENST00000535425(uc021wrz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCO2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCO2 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): SCO2 (NM_005138) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCO2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCO2 |
24/481 AceView cDNA sequences (see all 481): CR613294 BX104808 CD674272 CR623877 CB305725 CR608523 CR598122 BI962661 BG330140 CA313581 CD514194 AI765458 BF436372 BQ447931 CB152453 CR602986 CR610293 CR601424 CR600249 CR603653 BM725987 BE502258 BM127080 BG120390
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SCO2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c |
|---|
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| SP1: | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SCO2
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Expression
for SCO2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCO2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SCO2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCO2
UniProtKB/Swiss-Prot: SCO2_HUMAN, O43819Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for SCO2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCO2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SCO2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCO2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCO2 |
Orthologs
for SCO2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SCO2 gene from 9/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Sco21 , 5 |
SCO cytochrome oxidase deficient homolog 2 (yeast)1, 5 |
80.58(n)1
81.5(a)1 |
|
15 (44.85 cM)5
1001268241 NM_001111288.11 NP_001104758.11
893716395 |
chicken
(Gallus gallus) |
Aves |
SCO21 |
SCO cytochrome oxidase deficient homolog 2 (yeast) |
65.41(n)
61.76(a) |
|
429671 XM_003640326.1 XP_003640374.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
BU916872.12 |
-- |
75.53(n) |
|
BU916872.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
sco21 |
SCO cytochrome oxidase deficient homolog 2 (yeast) |
59.88(n)
62.9(a) |
|
606683 NM_001045232.1 NP_001038697.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG88853 |
-- |
51(a) |
|
25B5 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
C01F1.23 |
-- |
41(a) |
|
II(4299655-4300715) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SCO1(YBR037C)4
SCO21 |
Copper-binding protein of the mitochondrial inner membrane, more4
Sco2p1 |
47.42(n)1
38.5(a)1 |
|
2(311452-310565)4
8523121 NP_009580.11 8523254
NP_009593.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HCC16AT4G397406 |
electron transport SCO1/SenC family protein |
24(a)23(a) |
many ↔ manymany ↔ many |
3(2727215-2729601) 4(18435293-18437136) |
rice
(Oryza sativa) |
Liliopsida |
---- |
SCO1 protein homolog, mitochondrial precursor, put...SCO1 protein homolog, mitochondrial precursor, put... |
25(a)24(a) |
many ↔ manymany ↔ many |
2(3227506-3233932) 9(12288591-12293954) |
ENSEMBL Gene Tree for SCO2 (if available)
TreeFam Gene Tree for SCO2 (if available) |
Paralogs
for SCO2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SCO2 gene
- SCO12
1 SIMAP similar gene for SCO2 using alignment to 2 protein entries: SCO2_HUMAN (see all proteins):SCO1
SCO2 for paralogs About GeneDecksing
|
Genomic Variants
for SCO2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCO2 (50961997 - 50964868 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SCO2
2 CNVs: 4139 5192
Human Gene Mutation Database (HGMD): SCO2
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SCO2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCO2 for disorders About GeneDecksing
OMIM gene information: 604272
OMIM disorders: 604377
UniProtKB/Swiss-Prot: SCO2_HUMAN, O43819
Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency(FIC) [MIM:604377]. This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heartand skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mildCOX deficiencies
14  diseases for SCO2: About MalaCardswerdnig-hoffmann disease fatal infantile encephalocardiomyopathy spinal muscular atrophy cardioencephalomyopathy
muscular atrophy lactic acidosis amyotrophic lateral sclerosis lateral sclerosis
hypertrophic cardiomyopathy leigh disease gliosis cardiomyopathy
neuropathy malaria
2 diseases from the University of Copenhagen DISEASES database for SCO2:Leigh disease Hypertrophic cardiomyopathy 10 Novoseek disease relationships for SCO2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cytochrome c oxidase deficiency |
94 |
7 |
15499950 (1), 12020273 (1), 11751685 (1), 20159436 (1) (see all 6) |
| leigh syndrome |
88.1 |
7 |
11579424 (1), 10545952 (1), 12538779 (1), 10805329 (1) (see all 5) |
| mitochondrial diseases |
77.9 |
3 |
14759282 (1), 10749987 (1), 15659396 (1) |
| werdnig-hoffmann disease |
69.1 |
3 |
12020273 (2), 14994243 (1) |
| muscular atrophy spinal |
62 |
4 |
12020273 (2), 18332255 (1), 19879173 (1) |
| acidosis lactic |
61.3 |
2 |
19353431 (1), 19879173 (1) |
| encephalopathy |
60.9 |
5 |
19879173 (1), 11579424 (1), 15210538 (1), 10749987 (1) (see all 5) |
| cardiomyopathy |
56.3 |
4 |
19353431 (1), 19879173 (1), 16765077 (1), 16326995 (1) |
| tumors |
5.63 |
1 |
16843260 (1) |
| cancer |
0 |
2 |
16728594 (2) |
Genetic Association Database (GAD): SCO2
Human Genome Epidemiology (HuGE) Navigator: SCO2 (3 documents)
Export disorders for SCO2 gene to outside databases
|
Publications
for SCO2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCO2 gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with SCO2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in SCO2 are associated with a distinct form of hypertrophic cardiomyopathy and cytochrome c oxidase deficiency. (PubMed id 10749987)1, 2, 4, 9 Jaksch M.... Shoubridge E.A. (2000)
- Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene. (PubMed id 10545952)1, 2, 9 Papadopoulou L.C.... Schon E.A. (1999)
- A structural characterization of human SCO2. (PubMed id 17850752)1, 2 Banci L....Wang S. (2007)
- Human Sco1 and Sco2 function as copper-binding proteins. (PubMed id 16091356)1, 3 Horng Y.C....Winge D.R. (2005)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (2003)
- Homozygosity (E140K) in SCO2 causes delayed infantile onset of cardiomyopathy and neuropathy. (PubMed id 11673586)1, 2 Jaksch M.... Freisinger P. (2001)
- Human members of the SCO1 gene family: complementation analysis in yeast and intracellular localization. (PubMed id 10218584)1, 3 Paret C....Rodel G. (1999)
- Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1. (PubMed id 19336478)1, 9 Leary S.C....Shoubridge E.A. (2009)
|
External Searches for SCO2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCO2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCO2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCO2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SCO2 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SCO2 |
|
| | |
About This Section
| Patent Information for SCO2 gene:
Search GeneIP for patents involving SCO2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SCO2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SCO2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCO2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCO2 | | | OriGene Protein Over-expression Lysate for SCO2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SCO2 | | OriGene 3'-UTR Clone for SCO2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCO2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCO2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SCO2 | | OriGene Custom Protein Services for SCO2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCO2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCO2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCO2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCO2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCO2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCO2 |
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| | | | Search Tocris compounds for SCO2 |
| |  |  |  |  | | | | | | Recombinant Protein for SCO2 |
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 | | | SCO2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for SCO2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCO2 |
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