SCO1 Gene
protein-coding GIFtS: 57
GCID: GC17M010583
|
|
SCO1 cytochrome c oxidase assembly protein(Previous names: SCO (cytochrome oxidase deficient, yeast) homolog 1, SCO...)
(Previous symbol: SCOD1)
| |
Aliases
for SCO1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SCO1 Cytochrome C Oxidase Assembly Protein1 2 | | SCOD11 2 3 5 | | SCO (Cytochrome Oxidase Deficient, Yeast) Homolog 11 | | SCO Cytochrome Oxidase Deficient Homolog 1 (Yeast)1 | | Protein SCO1 Homolog, Mitochondrial2 | | SCO Cytochrome Oxidase Deficient Homolog 12 |
Export aliases for SCO1 gene to outside databasesPrevious GC identifers: GC17M010949 GC17M011698 GC17M010526 GC17M010784 GC17M010524 GC17M010483 |
Summaries
for SCO1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SCO1:
Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecularoxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 andSCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This geneis the human homolog to the yeast SCO1 gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SCO1_HUMAN, O75880Function: Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copperinto the active site of COX
Gene Wiki entry for SCO1
|
Genomic Views
for SCO1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCO1 gene promoter:
AML1a CUTL1 HNF-3beta FOXL1 E47 GATA-1 AREB6 GATA-6 Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCO1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCO1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1SCO1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M010583: view genomic region
(about GC identifiers)
Start:
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10,583,649 bp from pter |
End:
|
10,601,692 bp from pter |
Size:
|
18,044 bases |
Orientation:
|
minus strand |
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Proteins
for SCO1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCO1_HUMAN, O75880 (See
protein sequence)Recommended Name: Protein SCO1 homolog, mitochondrial precursor Size: 301 amino acids; 33814 Da
Subunit: Homodimer
Subcellular location: Mitochondrion
6/10 PDB 3D structures from  and Proteopedia  for SCO1 (see all 10):1WP0 (3D)
2GGT (3D)
2GQK (3D)
2GQL (3D)
2GQM (3D)
2GT5 (3D)
Secondary accessions: B2RDM0Explore the universe of human proteins at neXtProt for SCO1: NX_O75880
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75880
SCO1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004580.1
ENSEMBL proteins: ENSP00000255390 ENSP00000463387 ENSP00000464032 ENSP00000466435
Human Recombinant Protein Products for SCO1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SCO1 for ontologies About GeneDecksing
SCO1 Antibody Products:
Assay Products for SCO1: |
Protein
Domains /
Families
for SCO1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCO1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75880ProtoNet protein and cluster: O75880 1 Blocks protein family: IPB003782 Electron transport protein SCO1/SenC
UniProtKB/Swiss-Prot: SCO1_HUMAN, O75880Similarity: Belongs to the SCO1/2 family |
Function
for SCO1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SCO1_HUMAN, O75880Function: Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copperinto the active site of COX Genatlas biochemistry entry for SCO1:yeast SCO1 homolog,inner mitochondrial membrane in yeast,specifically required for a post-translational step of coxidase,either involved in transport or in the insertion of copper into the active site of the enzyme
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005507 | copper ion binding |
IEA | -- |
SCO1 for ontologies About GeneDecksing
Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Sco1):
SCO1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCO1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCO1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SCO1 (NM_004589) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCO1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCO1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCO1 |
|
Pathways & Interactions
for SCO1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | |
1  BioSystems Pathway for SCO1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCO1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/23 Interacting proteins for SCO1 (O758803 ENSP000002553904) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006091 | generation of precursor metabolites and energy |
TAS | 9878253 | | GO:0006825 | copper ion transport |
IEA | -- | | GO:0006878 | cellular copper ion homeostasis |
IEA | -- | | GO:0008535 | respiratory chain complex IV assembly |
IEA | -- |
SCO1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SCO1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SCO1 for compounds About GeneDecksing
 Browse Tocris compounds for SCO1
1 HMDB Compound for SCO1 About this table
4 Novoseek chemical compound relationships for SCO1 gene About this table
Search CenterWatch for drugs/clinical trials and news about SCO1
|
Transcripts
for SCO1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCO1 gene: NM_004589.2 Unigene Cluster for SCO1: SCO1 cytochrome c oxidase assembly protein Hs.14511 [show with all ESTs]Unigene Representative Sequence: NM_0045895 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000255390(uc002gmr.4) ENST00000577427 ENST00000577335 ENST00000582053
ENST00000579396
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCO1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCO1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SCO1 (NM_004589) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCO1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCO1 |
Additional cDNA sequence: AF026852.1 AF131816.1 AF183424.1 AK074588.1 AK098826.1 AK315595.1 BC015504.2 7 DOTS entries: DT.447481 DT.100811090 DT.100811089 DT.40220121 DT.100811091 DT.92427302 DT.95278904 24/209 AceView cDNA sequences (see all 209): CR621918 AF026852 BI818717 BM709047 BQ437964 BE858510 BM853034 BE389092 BI489918 AW024427 AF183424 AI094953 BI870191 BQ686666 CR593722 CF146557 AL555089 AI078479 CR611401 BM424176 CR615183 F08134 AA682787 AI076548
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SCO1 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | - | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SCO1
|
Expression
for SCO1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGGGGCGAG
About this image
See SCO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCO1
SOURCE GeneReport for Unigene cluster: Hs.14511
UniProtKB/Swiss-Prot: SCO1_HUMAN, O75880Tissue specificity: Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation(OxPhos), including muscle, heart, and brain
SABiosciences Custom PCR Arrays for SCO1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCO1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCO1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCO1 |
Orthologs
for SCO1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SCO1 gene from 8/38 species (see all 38) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SCO11 |
SCO cytochrome oxidase deficient homolog 1 (yeast) |
75.33(n)
78.53(a) |
|
426060 XM_423738.3 XP_423738.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SCO16 |
-- |
77(a) |
1 ↔ 1 |
2(108837287-108843762) |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01040209.16 |
-- |
51(a) |
1 ↔ 1 |
3(62859037-62865855) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG88853
Scox1 |
Synthesis of cytochrome c oxidase1 |
54(a)3
57.7(n)1
55.16(a)1 |
|
25B53
337111 NM_135040.31 NP_608884.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
C01F1.23
sco-11 |
Protein SCO-11 |
45(a)3
51.92(n)1
45.67(a)1 |
|
II(4299655-4300715)3
1737631 NM_062354.41 NP_494755.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SCO2(YBR024W)4
SCO11 |
Protein anchored to the mitochondrial inner membrane, more4
Sco1p1 |
48.59(n)1
40.3(a)1 |
|
2(289445-290350)4
8523251 NP_009593.11 8523124
NP_009580.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G089501 |
electron transport SCO1/SenC-like protein |
52.96(n)
45.33(a) |
|
820046 NM_111729.2 NP_566339.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.88722 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
71.31(n) |
|
AK073907.1 |
ENSEMBL Gene Tree for SCO1 (if available)
TreeFam Gene Tree for SCO1 (if available) |
Paralogs
for SCO1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SCO1 gene
- SCO22
1 SIMAP similar gene for SCO1 using alignment to 4 protein entries: SCO1_HUMAN (see all proteins):SCO2
SCO1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SCO1
PGOHUM00000239439
|
Genomic Variants
for SCO1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCO1 (10583649 - 10601692 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCO1: --
Human Gene Mutation Database (HGMD): SCO1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCO1 |
|
Disorders
/ Diseases
for SCO1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCO1 for disorders About GeneDecksing
OMIM gene information: 603644
OMIM disorders: --
UniProtKB/Swiss-Prot: SCO1_HUMAN, O75880
Defects in SCO1 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known ascytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinicalmanifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs.Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness,excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patientsmanifest Leigh syndrome
11  diseases for SCO1: About MalaCardshepatic failure, early onset, and neurologic disorder cardioencephalomyopathy menkes disease leigh disease
alzheimer's disease hypotonia liver disease hepatitis
hypoxia pancreatitis malaria
1 disease from the University of Copenhagen DISEASES database for SCO1:Leigh disease 4 Novoseek disease relationships for SCO1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cytochrome c oxidase deficiency |
86.3 |
1 |
11013136 (1) |
| mitochondrial diseases |
72.5 |
1 |
15659396 (1) |
| liver failure |
40.7 |
1 |
11013136 (1) |
| alzheimers disease |
12 |
3 |
17786024 (2), 17549012 (1) |
Human Genome Epidemiology (HuGE) Navigator: SCO1 (4 documents)
Export disorders for SCO1 gene to outside databases
|
Publications
for SCO1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCO1 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with SCO1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain. (PubMed id 9878253)1, 2, 3 Petruzzella V....Zeviani M. (1998)
- The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis. (PubMed id 17189203)1, 2, 9 Leary S.C....Shoubridge E.A. (2007)
- Characterization of human SCO1 and COX17 genes in mitochondrial cytochrome-c-oxidase deficiency. (PubMed id 11027508)1, 2, 9 Horvath R.... Jaksch M. (2000)
- Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase 'assembly' protein. (PubMed id 15659396)1, 2, 9 Williams J.C.... Schon E.A. (2005)
- Mutations of the SCO1 gene in mitochondrial cytochrome c oxidase deficiency with neonatal-onset hepatic failure and encephalopathy. (PubMed id 11013136)1, 2, 9 Valnot I.... Rotig A. (2000)
- A hint for the function of human Sco1 from different structures. (PubMed id 16735468)1, 2 Banci L.... Wang S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cytochrome c oxidase deficiency. (PubMed id 11579424)1, 2 Shoubridge E.A. (2001)
- Loss of function of Sco1 and its interaction with cytochrome c oxidase. (PubMed id 19295170)1, 9 Stiburek L....Zeman J. (2009)
- Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene. (PubMed id 10545952)1, 9 Papadopoulou L.C.... Schon E.A. (1999)
|
External Searches for SCO1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCO1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCO1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCO1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SCO1 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SCO1 |
|
| | |
About This Section
| Patent Information for SCO1 gene:
Search GeneIP for patents involving SCO1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SCO1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | OriGene Antibodies for SCO1 | | OriGene shRNA RFP for SCO1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCO1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCO1 | | | OriGene Protein Over-expression Lysate for SCO1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SCO1 | | OriGene 3'-UTR Clone for SCO1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCO1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCO1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SCO1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SCO1 | | OriGene Custom Protein Services for SCO1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCO1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCO1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCO1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCO1 |
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| | | | Search Tocris compounds for SCO1 |
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 | | | SCO1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCO1 |
|  |  |  |  | | | | ThermoFisher Antibodies for SCO1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCO1 |
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