Aliases for SCO1 Gene
External Ids for SCO1 Gene
Previous HGNC Symbols for SCO1 Gene
Previous GeneCards Identifiers for SCO1 Gene
Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SCO1 Gene
SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein) is a Protein Coding gene. Diseases associated with SCO1 include hepatic failure, early-onset, and neurologic disorder due to cytochrome c oxidase deficiency and fatal infantile cytochrome c oxidase deficiency. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include copper ion binding. An important paralog of this gene is SCO2.
UniProtKB/Swiss-Prot for SCO1 Gene
Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.