Aliases for SCNN1G Gene
External Ids for SCNN1G Gene
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]
GeneCards Summary for SCNN1G Gene
SCNN1G (Sodium Channel, Non Voltage Gated 1 Gamma Subunit) is a Protein Coding gene. Diseases associated with SCNN1G include bronchiectasis with or without elevated sweat chloride 3 and miliaria rubra. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include WW domain binding and ligand-gated sodium channel activity. An important paralog of this gene is ASIC2.
UniProtKB/Swiss-Prot for SCNN1G Gene
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.