Aliases for SCNN1D Gene
External Ids for SCNN1D Gene
Previous GeneCards Identifiers for SCNN1D Gene
GeneCards Summary for SCNN1D Gene
SCNN1D (Sodium Channel Epithelial 1 Delta Subunit) is a Protein Coding gene. Diseases associated with SCNN1D include Pseudohypoaldosteronism, Type I, Autosomal Recessive. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include sodium channel activity and ligand-gated sodium channel activity. An important paralog of this gene is SCNN1A.
UniProtKB/Swiss-Prot for SCNN1D Gene
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Epithelial sodium channels (ENaCs) are members of the ENaC/Deg (epithelial amiloride-sensitive Na+ channel and degenerin) family of ion channels. They are highly selective Na+ channels that are localized to polarized epithelial cells. ENaCs are responsible for Na+ reabsorption in the distal kidney tubule, and transport of Na+ across the epithelium.