Aliases for SCNN1D Gene
External Ids for SCNN1D Gene
GeneCards Summary for SCNN1D Gene
SCNN1D (Sodium Channel, Non Voltage Gated 1 Delta Subunit) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include ligand-gated sodium channel activity. An important paralog of this gene is SCNN1G.
UniProtKB/Swiss-Prot for SCNN1D Gene
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Epithelial sodium channels (ENaCs) are highly selective Na+ channels that are localized to polarized epithelial cells. They are responsible for sodium reabsorption in the distal kidney tubule, and have similar functions in the alveoli and colon. These channels transport Na+ across the epithelium using energy from the Na+, K+-ATPase, and constitute one of the essential mechanisms in regulation of sodium balance, blood volume and blood pressure. There are four ENaC subunits; alpha, beta, gamma and delta, which form functional heterotetramers. The kidney ENaC is thought to be a heterotetramer of 2alpha:1beta:1gamma. ENaCs are tonically open at rest. Ion flux is regulated by aldosterone-, vasopressin- and glucocorticoid-mediated changes in ENaC gene transcription and phosphatidylinositides act to stabilize the channel.