Aliases for SCNN1D Gene
- Sodium Channel Epithelial 1 Delta Subunit 2 3
- Sodium Channel, Non Voltage Gated 1 Delta Subunit 2 3 5
- Sodium Channel, Non-Voltage-Gated 1, Delta Subunit 2 3
- Nonvoltage-Gated Sodium Channel 1 Subunit Delta 3 4
- Sodium Channel, Nonvoltage-Gated 1, Delta 2 3
- Epithelial Na(+) Channel Subunit Delta 3 4
- Delta-ENaC 3 4
- Delta-NaCH 3 4
External Ids for SCNN1D Gene
Previous GeneCards Identifiers for SCNN1D Gene
GeneCards Summary for SCNN1D Gene
SCNN1D (Sodium Channel Epithelial 1 Delta Subunit) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). GO annotations related to this gene include sodium channel activity and ligand-gated sodium channel activity. An important paralog of this gene is SCNN1G.
UniProtKB/Swiss-Prot for SCNN1D Gene
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Epithelial sodium channels (ENaCs) are members of the ENaC/Deg (epithelial amiloride-sensitive Na+ channel and degenerin) family of ion channels. They are highly selective Na+ channels that are localized to polarized epithelial cells. ENaCs are responsible for sodium reabsorption in the distal kidney tubule, and transport Na+ across the epithelium. They have similar functions in alveoli and the colon.