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SCN9A Gene

protein-coding   GIFtS: 62

GC02M166763
sodium channel, voltage-gated, type IX, alpha subunit
(Previous names: sodium channel, voltage-gated, type IX, alpha polypeptide )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
ETHA 1, 2
NE-NA 1, 2
NENA 1, 2, 3, 5
Nav1.7 1, 2
PN1 1, 2, 3, 5
hNE-Na 3
Descriptions
Neuroendocrine sodium channel 3
Peripheral sodium channel 1 3
Sodium channel protein type IX subunit alpha 3
Voltage-gated sodium channel subunit alpha Nav1.7 3
sodium channel, voltage-gated, type IX, alpha 2
sodium channel, voltage-gated, type IX, alpha polypeptide 1, 2
sodium channel, voltage-gated, type IX, alpha subunit 2
voltage-gated sodium channel alpha subunit Nav1.7 2
External Ids
HGNC: 105971
Entrez Gene: 63352
UniProtKB: Q158583
Ensembl: ENSG000001694327
Search outside databases for aliases for SCN9A gene

Previous GC identifers: GC02M165109 GC02M165596 GC02M167018 GC02M167257 GC02M166880

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SCN9A_HUMAN, Q15858
Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming
opened or closed conformations in response to the voltage difference across the membrane, the
protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with
their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role
in pain mechanisms, especially in the development of inflammatory pain (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SCN9A gene  

Entrez Gene cytogenetic band: 2q24   Ensembl cytogenetic band:  2q24.3   HGNC cytogenetic band: 2q24

SCN9A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M166763:     (about GC identifiers)

Start:
166,759,941 bp from pter
End:
166,940,749 bp from pter
Size:
180,809 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.10  NT_005403.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SCN9A_HUMAN, Q15858 (See protein sequence)
Recommended Name: Sodium channel protein type 9 subunit alpha  
Size: 1988 amino acids; 226342 Da
Subunit: The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence
represents a large polypeptide. Interacts with NEDD4 and NEDD4L (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein. Note=In neurite terminals (By
similarity)
Secondary accessions: A1BUH5 Q6B4R9 Q6B4S0 Q6B4S1 Q70HX1 Q70HX2 Q8WTU1 Q8WWN4
Alternative splicing: 3 isoforms:  Q15858-1   Q15858-2   Q15858-3   

Post-translational modifications:

  • Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by
    NEDD4 (By similarity)1


  • REFSEQ proteins: NP_002968.1  

    ENSEMBL proteins: 
    ENSP00000364536 ENSP00000304748 ENSP00000386306 ENSP00000386330 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant SCN9A Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Nav1.7)
    Human Recombinant Proteins from Abnova (SCN9A)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001518 voltage-gated sodium channel complex IEA--
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for SCN9A: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of SCN9A
    Sigma-Aldrich Antibodies for SCN9A
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Nav1.7), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (SCN9A)
    Novus Biologicals Antibody for SCN9A

    Assays for SCN9A: 
    Browse Invitrogen for biochemical assays
    Millipore Kits and Assays for the Analysis of SCN9A
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR001696 Na_channel
     IPR010526 Na_trans_assoc
     IPR000048 IQ_CaM_bd_region
     IPR005821 Ion_trans


       GeneDecks  SCN9A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q15858

    ProtoNet protein and cluster: Q15858

    2 Blocks protein families:
    IPB000048 IQ calmodulin-binding region
    IPB001696 Voltage-gated Na+ channel alpha subunit signature


    UniProtKB/Swiss-Prot: SCN9A_HUMAN, Q15858
    Domain: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6)
    and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are
    characterized by a series of positively charged amino acids at every third position
    Similarity: Belongs to the sodium channel family
    Similarity: Contains 1 IQ domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SCN9A)
    Millipore RNAi Products for the Analysis of SCN9A Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (SCN9A)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002977

                  Applied Biosystems Silencer® siRNAs for SCN9A

                  Sigma-Aldrich siRNA and siRNA Panels for SCN9A  
                         Sigma-Aldrich shRNA Panels and shRNA for SCN9A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Millipore Clones for the Expression of SCN9A
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002977
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002977
                                     untagged cDNA clone in CMV expression vector: NM_002977 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002977

    UniProtKB/Swiss-Prot: SCN9A_HUMAN, Q15858
    Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming
    opened or closed conformations in response to the voltage difference across the membrane, the
    protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with
    their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role
    in pain mechanisms, especially in the development of inflammatory pain (By similarity)

    Genatlas biochemistry entry for SCN9A:
    sodium channel voltage-gated,type IX,alpha polypeptide,tetradotoxin sensitive,solely expressed in
    neuroendocrine cells

    4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Scn9a):

    behavior/neurologicallethality-prenatal/perinatalnervous systemtouch/vibrissae

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005244 voltage-gated ion channel activity IEA--
    GO:0005248 voltage-gated sodium channel activity TAS7720699
    GO:0031402 sodium ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Millipore Pathways for SCN9A
      ion currents
      inward current

       GeneDecks  SCN9A for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  SCN9A 


    4 Interacting proteins for SCN9A (ENSP000003047483) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PEPDENSP000002441373STRING (score=.843)
    NGFENSP000003585253STRING (score=.811)
    SCN1BENSP000002626313STRING (score=.772)
    SLCO6A1ENSP000003691353STRING (score=.708)
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811 ion transport IEA--
    GO:0006814 sodium ion transport TAS7720699
    GO:0006954 inflammatory response IEA--
    GO:0009791 post-embryonic development IEA--
    GO:0048266 behavioral response to pain IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for SCN9A
    Browse Small Molecules at Sigma-Aldrich

    Compounds for SCN9A available from Tocris Bioscience
    CompoundAction CAS number
    VinpocetineNa+ channel blocker[42971-09-5]
    Co 102862State-dependent Na+ channel blocker; anticonvulsant[181144-66-1]
    QX 314 chlorideNa+ channel blocker[5369-03-9]
    Flecainide acetateCardiac Na+ channel blocker. Antiarrhythmic[54143-56-5]
    Tetrodotoxin citrateCitrate salt of Cat. No. 1078[18660-81-6]
    About this table


    2 Novoseek chemical compound relationships for SCN9A gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium 70.17 34 9169448 (3), 17167479 (2), 14985375 (2), 16216943 (2) (see all 20)
    carrageenan 48.48 1 15030943 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SCN9A)
    Millipore RNAi Products for the Analysis of SCN9A Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (SCN9A)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002977

                  Sigma-Aldrich siRNA and siRNA Panels for SCN9A  
                         Sigma-Aldrich shRNA Panels and shRNA for SCN9A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002977  

    REFSEQ mRNAs for SCN9A gene: 

    NM_002977.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002977  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002977
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002977
                                     untagged cDNA clone in CMV expression vector: NM_002977 

    Additional cDNA sequence: 

    AJ277393.1 AJ310882.1 AJ310883.1 AJ310897.1 AK307549.1 AY682084.1 AY682085.1 AY682086.1 
    BC113079.1 BC113080.1 DQ857292.1 X82835.1 

    6 DOTS entries:

    DT.203056  DT.310741  DT.120960101  DT.100740641  DT.75152923  DT.92420091 

    24/26 AceView cDNA sequences (see all 26 ):

    AJ310882 NM_002977 AJ310883 AA298508 BX100638 X82835 CB146297 AJ277393 
    AJ310897 BG253038 BM993170 CK005041 AL517958 BX409894 BX409895 AY682086 
    AI091722 AY682085 AY682084 AL517957 BG483641 AA620400 BG227970 BG183871 

    highest scoring ESTs for SCN9A:

    X82835 AA298508 AL517958 AI091722 AJ277393 AJ310882 AJ310883 AJ310897 BF839574 BG483641 

    Unigene Cluster for SCN9A:

    Sodium channel, voltage-gated, type IX, alpha subunit
    Hs.439145  [show with all ESTs]
    Unigene Representative Sequence: NM_002977


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations:
    ENST00000375387  ENST00000303354  ENST00000409672  ENST00000409435  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SCN9A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SCN9A

    1 / 2 / 3

    6 probe-sets matching SCN9A gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    32947_at2, 3 U95-A 1 1.00 1.00 0.81 0.68 X82835 1.00 1.00 1.00 1
    57701_at2 U95-B 1 1.00 1.00 0.92 1.34 -- -- -- -- --

    206950_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002977 0.60 1.00 0.82 1

    229199_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    206950_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    229199_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  SCN9A for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.439145

    Expression variation in blood from EXPOLDB for SCN9A

    UniProtKB/Swiss-Prot: SCN9A_HUMAN, Q15858
    Tissue specificity: Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in
    the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed
    preferentially in the central and peripheral nervous system while isoform 2 is expressed
    preferentially in the dorsal root ganglion

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for SCN9A gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SCN9A1   -- sodium channel, voltage-gated, type IX, alpha subunit 91.54(n)
    94.53(a)
    488381  XM_545503.2  XP_545503.2 
    cow
    (Bos taurus)
    SCN9A1   -- sodium channel, voltage-gated, type IX, alpha subunit 91.28(n)
    94.53(a)
    533065  XM_612339.3  XP_612339.3 
    rat
    (Rattus norvegicus)
    Scn9a1   -- sodium channel, voltage-gated, type IX, alpha 86.82(n)
    93.21(a)
    78956  NM_133289.1  NP_579823.1 
    mouse
    (Mus musculus)
    Scn9a1, 5 2 (36.00 cM)5
    sodium channel, voltage-gated, type IX, alpha1, 5 86.5(n)1
    92.35(a)1
    202741  NM_018852.21  NP_061340.21 
     AK1418385  AK1418715  (see all 14)
    chicken
    (Gallus gallus)
    SCN9A1   -- sodium channel, voltage-gated, type IX, alpha subunit 75.72(n)
    76.55(a)
    395946  XM_422021.2  XP_422021.2 
    About this table        Species with no ortholog for SCN9A

    ENSEMBL Gene Tree for SCN9A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for SCN9A gene
    SCN2A2  SCN3A2  SCN1A2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/745 NCBI SNPs in SCN9A are shown (see all 745 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 217)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs41311621,2
    A,C,F,H166876710(-) ACACAC/TAGTAA 1 -- ng3111Minor allele frequency- T:0.44EU EA WA NA 972
    --
    rs75708621,2
    A,C,F,H166877962(+) tgaacG/Aataaa 1 -- ng313Minor allele frequency- A:0.47EU EA 270
    --
    rs44886771,2
    A,C,F166878116(+) cattgA/Caaatc 1 -- ng313Minor allele frequency- C:0.40NA 136
    rs124783181,2
    C,F,H166841786(+) GCACAT/GAGCTT 1 L/M mis18Minor allele frequency- G:0.03EU EA WA 808
    rs41311601,2
    C,F,H166876878(-) TTGAGC/TTGAAT 1 -- ng3112Minor allele frequency- T:0.43NS EU EA WA NA 664
    rs168517591,2
    C,F,H166763299(+) TCAGAG/ATTAGT 1 -- ut3111Minor allele frequency- A:0.04NA EU EA WA 980
    rs119029201,2
    C,F,H166762244(+) TGGCAA/CGAGAG 1 -- ut314Minor allele frequency- C:0.00EU EA WA 394
    rs41311591,2
    C,F,H166877061(-) gattgT/Ataagc 1 -- ng31 tfbs312Minor allele frequency- A:0.43NS EU EA WA NA 658
    rs41311611,2
    A,C,F166876784(-) TGAAGG/CGTAAA 1 -- ng31 tfbs37Minor allele frequency- C:0.43NA EA 490
    rs43698761,2
    C,F,H166837502(+) TTTCAC/AATAAT 1 L/V mis14Minor allele frequency- A:0.03EU EA WA 406
    About this table

    HapMap Linkage Disequilibrium images for SCN9A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 603415   disorders: 133020  243000  167400  

    UniProtKB/Swiss-Prot: SCN9A_HUMAN, Q15858

  • Defects in SCN9A are the cause of primary erythermalgia [MIM:133020]. It is an autosomal
    dominant disease characterized by recurrent episodes of severe pain associated with redness and
    warmth in the feet or hands
  • Defects in SCN9A are the cause of autosomal recessive congenital indifference to pain
    [MIM:243000]; also known as channelopathy-associated insensitivity to pain. Affected individuals
    have a congenital inability to perceive any form of pain, in any part of the body. All other
    sensory modalities are preserved and the peripheral and central nervous systems are apparently
    intact. Patients perceive the sensations of touch, warm and cold temperature, proprioception,
    tickle and pressure, but not painful stimuli. There is no evidence of a motor or sensory
    neuropathy, either axonal or demyelinating
  • Defects in SCN9A are a cause of paroxysmal extreme pain disorder (PEPD) [MIM:167400];
    previously known as familial rectal pain (FRP). PEPD is an autosomal dominant paroxysmal disorder
    of pain and autonomic dysfunction. The distinctive features are paroxysmal episodes of burning
    pain in the rectal, ocular, and mandibular areas accompanied by autonomic manifestations such as
    skin flushing
  • 2 Novoseek disease relationships for SCN9A gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythromelalgia 93.19 14 14985375 (3), 18347287 (3), 15314237 (1), 19361700 (1) (see all 8)
    prostate cancer 23.89 2 16088330 (1), 18596065 (1)
    About this table

    GeneTests: SCN9A
    SCN9A-Related Inherited Erythromelalgia

    Human Gene Mutation Database: SCN9A
    Human Genome Epidemiology Navigator: SCN9A (2 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/62 PubMed articles for SCN9A gene (see all 62 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 6335 HGNC: 10597 AceView: SCN9A Ensembl:ENSG00000169432 euGenes: HUgn6335
    ECgene: SCN9A H-InvDB: SCN9A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    GeneReviewshttp://www.genetests.org/query?gene=SCN9A
    Wikipedia http://en.wikipedia.org/wiki/SCN9A
    Protein Spotlighthttp://www.expasy.org/spotlight/back_issues/sptlt102.shtml
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SCN9A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SCN9A-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for SCN9A Antibodies for SCN9A
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for SCN9A Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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