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SCN9A Gene

protein-coding GIFtS: 62

GC02M166763

sodium channel, voltage-gated, type IX, alpha subunit
(Previous names: sodium channel, voltage-gated, type IX, alpha polypeptide )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ETHA ^¹, ²
NE-NA ^¹, ²
NENA ^¹, ², ³, ⁵
Nav1.7 ^¹, ²
PN1 ^¹, ², ³, ⁵
hNE-Na ^³

Descriptions
Neuroendocrine sodium channel ^³
Peripheral sodium channel 1 ^³
Sodium channel protein type IX subunit alpha ^³
Voltage-gated sodium channel subunit alpha Nav1.7 ^³
sodium channel, voltage-gated, type IX, alpha ^²
sodium channel, voltage-gated, type IX, alpha polypeptide ^¹, ²
sodium channel, voltage-gated, type IX, alpha subunit ^²
voltage-gated sodium channel alpha subunit Nav1.7 ^²

External Ids
HGNC: 10597¹
Entrez Gene: 6335²
UniProtKB: Q15858³
Ensembl: ENSG00000169432⁷

Search outside databases for aliases for SCN9A gene

Previous GC identifers: GC02M165109 GC02M165596 GC02M167018 GC02M167257 GC02M166880

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SCN9A_HUMAN, Q15858

Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming

opened or closed conformations in response to the voltage difference across the membrane, the

protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with

their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role

in pain mechanisms, especially in the development of inflammatory pain (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SCN9A gene

Entrez Gene cytogenetic band: 2q24 Ensembl cytogenetic band: 2q24.3 HGNC cytogenetic band: 2q24

SCN9A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M166763: (about GC identifiers)

Start:	166,759,941 bp from pter
End:	166,940,749 bp from pter
Size:	180,809 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SCN9A_HUMAN, Q15858 (See protein sequence)

Recommended Name: Sodium channel protein type 9 subunit alpha

Size: 1988 amino acids; 226342 Da

Subunit: The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence

represents a large polypeptide. Interacts with NEDD4 and NEDD4L (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein. Note=In neurite terminals (By

similarity)

Secondary accessions: A1BUH5 Q6B4R9 Q6B4S0 Q6B4S1 Q70HX1 Q70HX2 Q8WTU1 Q8WWN4

Alternative splicing: 3 isoforms: Q15858-1 Q15858-2 Q15858-3

Post-translational modifications:

Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by

NEDD4 (By similarity)¹

REFSEQ proteins: NP_002968.1

ENSEMBL proteins:

ENSP00000364536 ENSP00000304748 ENSP00000386306 ENSP00000386330

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant SCN9A Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Nav1.7)
	Human Recombinant Proteins from Abnova (SCN9A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001518	voltage-gated sodium channel complex	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for SCN9A:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of SCN9A
	Sigma-Aldrich Antibodies for SCN9A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Nav1.7), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SCN9A)
	Novus Biologicals Antibody for SCN9A

Assays for SCN9A:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of SCN9A
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q15858

ProtoNet protein and cluster: Q15858

2 Blocks protein families:

IPB000048 IQ calmodulin-binding region

IPB001696 Voltage-gated Na+ channel alpha subunit signature

UniProtKB/Swiss-Prot: SCN9A_HUMAN, Q15858

Domain: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6)

and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are

characterized by a series of positively charged amino acids at every third position

Similarity: Belongs to the sodium channel family

Similarity: Contains 1 IQ domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SCN9A)
		Millipore RNAi Products for the Analysis of SCN9A Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (SCN9A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002977

Applied Biosystems Silencer® siRNAs for SCN9A

Sigma-Aldrich siRNA and siRNA Panels for SCN9A

Sigma-Aldrich shRNA Panels and shRNA for SCN9A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of SCN9A

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002977
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002977
untagged cDNA clone in CMV expression vector: NM_002977

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002977

UniProtKB/Swiss-Prot: SCN9A_HUMAN, Q15858

Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming

opened or closed conformations in response to the voltage difference across the membrane, the

protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with

their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role

in pain mechanisms, especially in the development of inflammatory pain (By similarity)

Genatlas biochemistry entry for SCN9A:

sodium channel voltage-gated,type IX,alpha polypeptide,tetradotoxin sensitive,solely expressed in

neuroendocrine cells

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Scn9a):

behavior/neurological

lethality-prenatal/perinatal

nervous system

touch/vibrissae

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005248	voltage-gated sodium channel activity	TAS	7720699
GO:0031402	sodium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for SCN9A

4 Interacting proteins for SCN9A (ENSP00000304748³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PEPD	ENSP00000244137³	STRING (score=.843)
NGF	ENSP00000358525³	STRING (score=.811)
SCN1B	ENSP00000262631³	STRING (score=.772)
SLCO6A1	ENSP00000369135³	STRING (score=.708)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006814	sodium ion transport	TAS	7720699
GO:0006954	inflammatory response	IEA	--
GO:0009791	post-embryonic development	IEA	--
GO:0048266	behavioral response to pain	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for SCN9A

Browse Small Molecules at Sigma-Aldrich

Compounds for SCN9A available from Tocris Bioscience

Compound	Action	CAS number
Vinpocetine	Na+ channel blocker	[42971-09-5]
Co 102862	State-dependent Na+ channel blocker; anticonvulsant	[181144-66-1]
QX 314 chloride	Na+ channel blocker	[5369-03-9]
Flecainide acetate	Cardiac Na+ channel blocker. Antiarrhythmic	[54143-56-5]
Tetrodotoxin citrate	Citrate salt of Cat. No. 1078	[18660-81-6]

About this table

2 Novoseek chemical compound relationships for SCN9A gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sodium	70.17	34	9169448 (3), 17167479 (2), 14985375 (2), 16216943 (2) (see all 20)
carrageenan	48.48	1	15030943 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SCN9A)
		Millipore RNAi Products for the Analysis of SCN9A Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (SCN9A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002977

Sigma-Aldrich siRNA and siRNA Panels for SCN9A

Sigma-Aldrich shRNA Panels and shRNA for SCN9A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002977

REFSEQ mRNAs for SCN9A gene:

NM_002977.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002977

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002977
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002977
                                 untagged cDNA clone in CMV expression vector: NM_002977

Additional cDNA sequence:

AJ277393.1 AJ310882.1 AJ310883.1 AJ310897.1 AK307549.1 AY682084.1 AY682085.1 AY682086.1

BC113079.1 BC113080.1 DQ857292.1 X82835.1

6 DOTS entries:

DT.203056 DT.310741 DT.120960101 DT.100740641 DT.75152923 DT.92420091

24/26 AceView cDNA sequences (see all 26 ):

AJ310882 NM_002977 AJ310883 AA298508 BX100638 X82835 CB146297 AJ277393

AJ310897 BG253038 BM993170 CK005041 AL517958 BX409894 BX409895 AY682086

AI091722 AY682085 AY682084 AL517957 BG483641 AA620400 BG227970 BG183871

highest scoring ESTs for SCN9A:

X82835 AA298508 AL517958 AI091722 AJ277393 AJ310882 AJ310883 AJ310897 BF839574 BG483641

Unigene Cluster for SCN9A:

Sodium channel, voltage-gated, type IX, alpha subunit

Hs.439145 [show with all ESTs]

Unigene Representative Sequence: NM_002977

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000375387 ENST00000303354 ENST00000409672 ENST00000409435

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SCN9A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SCN9A

¹ / ² / ³

6 probe-sets matching SCN9A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32947_at²^{, 3}	U95-A	1	1.00	1.00	0.81	0.68	X82835	1.00	1.00	1.00	1
57701_at²	U95-B	1	1.00	1.00	0.92	1.34	--	--	--	--	--
206950_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002977	0.60	1.00	0.82	1
229199_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
206950_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229199_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SCN9A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.439145
Expression variation in blood from EXPOLDB for SCN9A
UniProtKB/Swiss-Prot: SCN9A_HUMAN, Q15858
Tissue specificity: Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in
the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed
preferentially in the central and peripheral nervous system while isoform 2 is expressed
preferentially in the dorsal root ganglion

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SCN9A gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SCN9A¹	--	sodium channel, voltage-gated, type IX, alpha subunit	91.54(n) 94.53(a)	488381 XM_545503.2 XP_545503.2
cow (Bos taurus)	SCN9A¹	--	sodium channel, voltage-gated, type IX, alpha subunit	91.28(n) 94.53(a)	533065 XM_612339.3 XP_612339.3
rat (Rattus norvegicus)	Scn9a¹	--	sodium channel, voltage-gated, type IX, alpha	86.82(n) 93.21(a)	78956 NM_133289.1 NP_579823.1
mouse (Mus musculus)	Scn9a^{1, 5}	2 (36.00 cM)⁵	sodium channel, voltage-gated, type IX, alpha^{1, 5}	86.5(n)¹ 92.35(a)¹	20274¹ NM_018852.2¹ NP_061340.2¹ AK141838⁵ AK141871⁵ (see all 14)
chicken (Gallus gallus)	SCN9A¹	--	sodium channel, voltage-gated, type IX, alpha subunit	75.72(n) 76.55(a)	395946 XM_422021.2 XP_422021.2

About this table Species with no ortholog for SCN9A

ENSEMBL Gene Tree for SCN9A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SCN9A gene

SCN2A² SCN3A² SCN1A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/745 NCBI SNPs in SCN9A are shown (see all 745 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 217)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4131162^1,2	A,C,F,H	166876710(-)	`ACACAC/TAGTAA`	1	--	ng3¹		11	EU EA WA NA	972
--	rs7570862^1,2	A,C,F,H	166877962(+)	`tgaacG/Aataaa`	1	--	ng3¹		3	EU EA	270
--	rs4488677^1,2	A,C,F	166878116(+)	`cattgA/Caaatc`	1	--	ng3¹		3	NA	136
	rs12478318^1,2	C,F,H	166841786(+)	`GCACAT/GAGCTT`	1	L/M	mis¹		8	EU EA WA	808
	rs4131160^1,2	C,F,H	166876878(-)	`TTGAGC/TTGAAT`	1	--	ng3¹		12	NS EU EA WA NA	664
	rs16851759^1,2	C,F,H	166763299(+)	`TCAGAG/ATTAGT`	1	--	ut3¹		11	NA EU EA WA	980
	rs11902920^1,2	C,F,H	166762244(+)	`TGGCAA/CGAGAG`	1	--	ut3¹		4	EU EA WA	394
	rs4131159^1,2	C,F,H	166877061(-)	`gattgT/Ataagc`	1	--	ng3¹ tfbs³		12	NS EU EA WA NA	658
	rs4131161^1,2	A,C,F	166876784(-)	`TGAAGG/CGTAAA`	1	--	ng3¹ tfbs³		7	NA EA	490
	rs4369876^1,2	C,F,H	166837502(+)	`TTTCAC/AATAAT`	1	L/V	mis¹		4	EU EA WA	406

About this table

HapMap Linkage Disequilibrium images for SCN9A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603415 disorders: 133020 243000 167400

UniProtKB/Swiss-Prot: SCN9A_HUMAN, Q15858

Defects in SCN9A are the cause of primary erythermalgia [MIM:133020]. It is an autosomal

dominant disease characterized by recurrent episodes of severe pain associated with redness and

warmth in the feet or hands

Defects in SCN9A are the cause of autosomal recessive congenital indifference to pain

[MIM:243000]; also known as channelopathy-associated insensitivity to pain. Affected individuals

have a congenital inability to perceive any form of pain, in any part of the body. All other

sensory modalities are preserved and the peripheral and central nervous systems are apparently

intact. Patients perceive the sensations of touch, warm and cold temperature, proprioception,

tickle and pressure, but not painful stimuli. There is no evidence of a motor or sensory

neuropathy, either axonal or demyelinating

Defects in SCN9A are a cause of paroxysmal extreme pain disorder (PEPD) [MIM:167400];

previously known as familial rectal pain (FRP). PEPD is an autosomal dominant paroxysmal disorder

of pain and autonomic dysfunction. The distinctive features are paroxysmal episodes of burning

pain in the rectal, ocular, and mandibular areas accompanied by autonomic manifestations such as

skin flushing

2 Novoseek disease relationships for SCN9A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
erythromelalgia	93.19	14	14985375 (3), 18347287 (3), 15314237 (1), 19361700 (1) (see all 8)
prostate cancer	23.89	2	16088330 (1), 18596065 (1)

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GeneTests: SCN9A

SCN9A-Related Inherited Erythromelalgia

Human Gene Mutation Database: SCN9A
Human Genome Epidemiology Navigator: SCN9A (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/62 PubMed articles for SCN9A gene (see all 62 ):

Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells. (PubMed id 7720699)^{1, 2, 3, 4} Klugbauer N.... Hofmann F. (1995)
An SCN9A channelopathy causes congenital inability to experience pain. (PubMed id 17167479)^{1, 3, 4} Cox J.J.... Woods C.G. (2006)
Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. (PubMed id 14985375)^{1, 3, 4} Yang Y.... Shen Y. (2004)
A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia. (PubMed id 9169448)^{1, 3, 4} Sangameswaran L.... Hunter J.C. (1997)
Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy. (PubMed id 15385606)^{1, 3, 4} Cummins T.R.... Waxman S.G. (2004)
Autosomal dominant erythermalgia associated with a novel mutation in the voltage-gated sodium channel alpha subunit Nav1.7. (PubMed id 16216943)^{1, 3, 4} Michiels J.J.... Drenth J.P.H. (2005)
Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons. (PubMed id 15958509)^{3, 4} Dib-Hajj S.D.... Waxman S.G. (2005)
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. (PubMed id 16382098)^{2, 3} Catterall W.A....Waxman S.G. (2005)
Expression of alternatively spliced sodium channel alpha-subunit genes: unique splicing patterns are observed in dorsal root ganglia. (PubMed id 15302875)^{3, 4} Raymond C.K.... Johnson J.M. (2004)
Voltage-gated sodium channel expressed in cultured human smooth muscle cells: involvement of SCN9A. (PubMed id 15178348)^{3, 4} Jo T.... Nakajima T. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6335	HGNC: 10597	AceView: SCN9A	Ensembl:ENSG00000169432	euGenes: HUgn6335
ECgene: SCN9A	H-InvDB: SCN9A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=SCN9A
Wikipedia	http://en.wikipedia.org/wiki/SCN9A
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt102.shtml

Licensable Technologies for SCN9A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SCN9A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SCN9A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SCN9A		Antibodies for SCN9A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SCN9A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SCN9A)
	Antibodies (SCN9A)
	Chimera RNAi (SCN9A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (Nav1.7)

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Antibodies for SCN9A

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SCN9A Gene at Home site.
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SCN9A Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for SCN9A

Summaries
for SCN9A

Genomic Location
for SCN9A

Proteins
for SCN9A

Protein Domains/
Families
for SCN9A

Gene Function
for SCN9A

Pathways & Interactions
for SCN9A

Drugs & Compounds
for SCN9A

Transcripts
for SCN9A

Expression
for SCN9A

Orthologs
for SCN9A

Paralogs
for SCN9A

SNPs/Variants
for SCN9A

Disorders & Mutations
for SCN9A

Medical News
for SCN9A

Publications
for SCN9A

Search for SCN9A

Genome Databases showing SCN9A

Other Databases showing SCN9A

Specialized Databases showing SCN9A

Licensable Technologies
for SCN9A

Services
for SCN9A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SCN9A Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor SCN9A

Summariesfor SCN9A

Genomic Locationfor SCN9A

Proteinsfor SCN9A

Protein Domains/Familiesfor SCN9A

Gene Functionfor SCN9A

Pathways & Interactionsfor SCN9A

Drugs & Compoundsfor SCN9A

Transcriptsfor SCN9A

Expression for SCN9A

Orthologsfor SCN9A

Paralogsfor SCN9A

SNPs/Variantsfor SCN9A

Disorders & Mutationsfor SCN9A

Medical Newsfor SCN9A

Publicationsfor SCN9A

Search for SCN9A

Genome Databases showing SCN9A

Other Databases showing SCN9A

Specialized Databases showing SCN9A

Licensable Technologiesfor SCN9A

Servicesfor SCN9A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SCN9A

Summaries
for SCN9A

Genomic Location
for SCN9A

Proteins
for SCN9A

Protein Domains/
Families
for SCN9A

Gene Function
for SCN9A

Pathways & Interactions
for SCN9A

Drugs & Compounds
for SCN9A

Transcripts
for SCN9A

Expression
for SCN9A

Orthologs
for SCN9A

Paralogs
for SCN9A

SNPs/Variants
for SCN9A

Disorders & Mutations
for SCN9A

Medical News
for SCN9A

Publications
for SCN9A

Licensable Technologies
for SCN9A

Services
for SCN9A