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GIFtS

SCN7A Gene

protein-coding   GIFtS: 52
GCID: GC02M167225

sodium channel, voltage-gated, type VII, alpha subunit

(Previous names: sodium channel, voltage-gated, type VI, alpha, sodium channel,...)
(Previous symbol: SCN6A)
 Explore 25 diseases affiliated with
SCN7A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SCN7A    

Aliases
for SCN7A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sodium Channel, Voltage-Gated, Type VII, Alpha Subunit1 2     Sodium Channel Protein Type VII Subunit Alpha2 3
SCN6A1 2 3 5     Sodium Channel, Voltage-Gated, Type VI, Alpha1
NaG1 2     Sodium Channel, Voltage-Gated, Type VII, Alpha1
Nav2.11 2     Sodium Channel Protein Type 7 Subunit Alpha2
Nav2.21 2     Sodium Channel, Voltage-Gated, Type VI, Alpha Polypeptide2
Putative Voltage-Gated Sodium Channel Subunit Alpha Nax2 3     Voltage-Dependent Sodium Channel Alpha Subunit2
Sodium Channel Protein Cardiac And Skeletal Muscle Subunit Alpha2 3     

External Ids:    HGNC: 105941   Entrez Gene: 63322   Ensembl: ENSG000001365467   OMIM: 1823925   UniProtKB: Q011183   

Export aliases for SCN7A gene to outside databases

Previous GC identifers: GC02M165317 GC02M165803 GC02M167464 GC02M167087 GC02M166970 GC02M159142


Summaries
for SCN7A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SCN7A:
This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles
during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This
sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower
compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer
positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to
other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of
all of them remain unknown. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: SCN7A_HUMAN, Q01118
Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed
conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel
through which Na(+) ions may pass in accordance with their electrochemical gradient

Gene Wiki entry for SCN7A


Genomic Views
for SCN7A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCN7A gene promoter:
         TBP   ISGF-3   Pbx1a   FOXO3   CUTL1   FOXO3b   FOXO1a   FOXO3a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCN7A promoter sequence
   Search SABiosciences Chromatin IP Primers for SCN7A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCN7A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21-q23   Ensembl cytogenetic band:  2q24.3   HGNC cytogenetic band: 2q21-q23

SCN7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCN7A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M167225:  view genomic region     (about GC identifiers)

Start:
 167,260,083 bp from pter      End:
 167,350,757 bp from pter
Size:
 90,675 bases      Orientation:
 minus strand

Proteins
for SCN7A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SCN7A_HUMAN, Q01118 (See protein sequence)
Recommended Name: Sodium channel protein type 7 subunit alpha  
Size: 1682 amino acids; 193493 Da
Subcellular location: Membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for SCN7A: NX_Q01118

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01118

    • SCN7A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002967.2  
    ENSEMBL proteins: 
     ENSP00000386796   ENSP00000396600   ENSP00000413699   ENSP00000403846  
    Reactome Protein details: Q01118
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001518voltage-gated sodium channel complex IEA--
    GO:0016021integral to membrane ----


    SCN7A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SCN7A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SCN7A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001696 Na_channel_asu
     IPR010526 Na_trans_assoc
     IPR000048 IQ_motif_EF-hand-BS
     IPR005821 Ion_trans_dom

    Graphical View of Domain Structure for InterPro Entry Q01118

    ProtoNet protein and cluster: Q01118

    2 Blocks protein families:
    IPB000048 IQ calmodulin-binding region
    IPB001696 Voltage-gated Na+ channel alpha subunit signature


    UniProtKB/Swiss-Prot: SCN7A_HUMAN, Q01118
    Domain: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively
    charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively
    charged amino acids at every third position
    Similarity: Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily


    Function
    for SCN7A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SCN7A_HUMAN, Q01118
    Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed
    conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel
    through which Na(+) ions may pass in accordance with their electrochemical gradient

    miRNA
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    hsa-miR-3910 hsa-miR-607 hsa-miR-3200-5p hsa-miR-29c hsa-miR-29a hsa-miR-200a hsa-miR-340 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmid: SCN7A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005248voltage-gated sodium channel activity IEA--


    SCN7A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SCN7A:
     Increased gamma-H2AX phosphory 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Scn7a):
     behavior/neurological  taste/olfaction 

    SCN7A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SCN7A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		L1CAM interactions0.39
    		Developmental Biology0.69
    2Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    		Neuropathic Pain-Signaling in Dorsal Horn Neurons1.00
    		Cholera Infection0.40
    		Aldosterone Signaling in Epithelial Cells0.47
    4Interaction between L1 and Ankyrins
    		Interaction between L1 and Ankyrins1.00
    5G-Beta Gamma Signaling
    		GHRH Signaling0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SCN7A (see all 7)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    PKA Signaling
    cAMP Pathway
    Aldosterone Signaling in Epithelial Cells

    4        Reactome Pathways for SCN7A
        L1CAM interactions
    Developmental Biology
    Interaction between L1 and Ankyrins
    Axon guidance



    SCN7A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCN7A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for SCN7A (ENSP000003867964) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCN10AENSP000003906004STRING: ENSP00000390600
    SCN11AENSP000003075994STRING: ENSP00000307599
    SCN1AENSP000003645544STRING: ENSP00000364554
    SCN1BENSP000003969154STRING: ENSP00000396915
    SCN2AENSP000002832564STRING: ENSP00000283256
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport TAS1317577
    GO:0006936muscle contraction TAS1317577


    SCN7A for ontologies           About GeneDecksing



    Drugs & Compounds
    for SCN7A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCN7A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SCN7A

    1 HMDB Compound for SCN7A    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    4 Novoseek chemical compound relationships for SCN7A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grayanotoxin 83.7 2 11562450 (1), 12150970 (1)
    sodium 79.3 72 14985375 (2), 1657647 (2), 10842222 (2), 15037518 (2) (see all 56)
    serine 3.92 1 10381583 (1)
    calcium 0 1 15072700 (1)

    Search CenterWatch for drugs/clinical trials and news about SCN7A 

    Transcripts
    for SCN7A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SCN7A gene: 
    NM_002976.3  

    Unigene Cluster for SCN7A:

    Sodium channel, voltage-gated, type VII, alpha subunit
    Hs.596087  [show with all ESTs]
    Unigene Representative Sequence: NR_045628
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409855(uc010fpm.2 uc002udu.2) ENST00000424326 ENST00000419992(uc002udv.1)
    ENST00000441411 ENST00000497562

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SCN7A (see all 21):
    hsa-miR-3910 hsa-miR-607 hsa-miR-3200-5p hsa-miR-29c hsa-miR-29a hsa-miR-200a hsa-miR-340 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmid: SCN7A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCN7A (see all 7)
    OriGene shRNA RFP: SCN7A
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK308450.1 BC062699.1 BC141864.1 M91556.1 NR_045628.1 S75992.1 

    3 DOTS entries:

    DT.113222  DT.95074216  DT.97805275 

    24/81 AceView cDNA sequences (see all 81):

    AI016423 AA970015 BE645306 BC062699 BI496536 BI963973 AW118118 BQ267802 
    CK903677 AI381295 BI493053 BQ898237 S75992 BF447497 N75192 BI494261 
    CD722152 CA438510 BQ879499 AA621572 AW340347 AI828648 AL700370 AA453997 

    GeneLoc Exon Structure


    Expression
    for SCN7A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCN7A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTTATATGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SCN7A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    HeartMyocardiumMature Cardiac FibroblastsEpicardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)

    See SCN7A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCN7A

    SOURCE GeneReport for Unigene cluster: Hs.596087

    UniProtKB/Swiss-Prot: SCN7A_HUMAN, Q01118
    Tissue specificity: Heart and uterus

        SABiosciences Custom PCR Arrays for SCN7A
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    In Situ
    Assay Products:     
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    Orthologs
    for SCN7A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SCN7A gene from 1/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    fruit fly
    (Drosophila melanogaster)    		 Insecta para6
    		 paralytic
    		 29(a)
    		 1 → many
    		 X(16352900-16421447)


    ENSEMBL Gene Tree for SCN7A (if available)
    TreeFam Gene Tree for SCN7A (if available) 

    Paralogs
    for SCN7A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCN7A gene
    CACNA1A2  SCN5A2  SCN9A2  CACNA1D2  CACNA1I2  CACNA1F2  SCN8A2  CACNA1G2  
    SCN10A2  SCN3A2  CACNA1E2  SCN2A2  CACNA1H2  CACNA1S2  CACNA1C2  SCN11A2  
    SCN4A2  SCN1A2  CACNA1B2  
    11 SIMAP similar genes for SCN7A using alignment to 4 protein entries:     SCN7A_HUMAN (see all proteins):
    SCN4A    SCN3A    SCN9A    SCN8A    SCN2A    SCN5A
    SCN1A    SCN11A    SCN10A    TPCN1    SCN2A2

    SCN7A for paralogs           About GeneDecksing



    Genomic Variants
    for SCN7A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1420 NCBI SNPs in SCN7A are shown (see all 1420)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1147279271,2
    		C,F,--167259695(+) TATCTT/GTAAAA 2 -- ds5001 int11Minor allele frequency- G:0.02NA 120
    rs781163291,2
    		F,--167259706(+) CAATTT/GCAAGT 2 -- ds5001 int11Minor allele frequency- G:0.02WA 118
    rs1439696291,2
    		--167259731(+) AATGAA/TGCACA 2 -- ds5001 int10--------
    rs799393901,2
    		F,--167259831(+) AATACG/AAAAAT 2 -- ds5001 int11Minor allele frequency- A:0.03NA 120
    rs76051781,2
    		C,F,A,H,--167259975(+) GTTTCC/TAGTTT 2 -- int1 ds500110Minor allele frequency- T:0.09NS EA NA WA 1196
    rs129919781,2
    		C,F,A,H,--167260048(+) GCCAAT/CGTGAT 2 -- int1 ds50017Minor allele frequency- C:0.05NS EA NA WA 654
    rs1451141871,2
    		--167260179(+) CTTTCA/GGAAGG 2 -- nc-transcript-variantut310--------
    rs1491190521,2
    		--167260219(+) GATAAA/CCTTTT 2 -- nc-transcript-variantut310--------
    rs1422112601,2
    		--167260252(+) CTTTAC/TGCAAT 2 -- nc-transcript-variantut310--------
    rs1512059161,2
    		--167260335(+) AAAACA/GGAGCT 2 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for SCN7A (167260083 - 167350757 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SCN7A: --

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    DNA2.0 Custom Variant and Variant Library Synthesis for SCN7A

    Disorders / Diseases
    for SCN7A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SCN7A for disorders           About GeneDecksing

    OMIM gene information: 182392    OMIM disorders: --

    20/25 diseases for SCN7A (see all 25):    About MalaCards
    hypokalemic periodic paralysis    hypokalemic periodic paralysis type 2    generalized epilepsy with febrile seizures plus    normokalemic periodic paralysis
    paramyotonia congenita    familial periodic paralysis    febrile seizures    paralysis
    generalized epilepsy    erythromelalgia    erythermalgia    amyotrophic lateral sclerosis
    malignant hyperthermia    lateral sclerosis    myotonia    neuronitis
    seizures    essential hypertension    hypertension    ovarian cancer

    3 Novoseek disease relationships for SCN7A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    periodic paralysis 84.6 2 8385647 (1), 8382500 (1)
    hypokalemic periodic paralysis 63.9 1 15072700 (1)
    erythromelalgia 62.8 2 14985375 (1), 16471234 (1)

    Genetic Association Database (GAD): SCN7A
    Human Genome Epidemiology (HuGE) Navigator: SCN7A (2 documents)

    Export disorders for SCN7A gene to outside databases

    Publications
    for SCN7A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCN7A gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with SCN7A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family. (PubMed id 1317577)1, 2, 9 George A.L. Jr.... Tamkun M.M. (1992)
    2. [Association of single nucleotide polymorphism in human SCN7A gene with essential hypertension in Chinese] (PubMed id 14669210)1, 4 Zhang K.X....Huang W. (2003)
    3. Evolution and diversity of mammalian sodium channel genes. (PubMed id 10198179)1, 3 Plummer N.W. and Meisler M.H. (1999)
    4. Assignment of a human voltage-dependent sodium channel alpha-subunit gene (SCN6A) to 2q21-q23. (PubMed id 8188276)1, 9 George A.L....Brown G.B. (1994)
    5. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PubMed id 19451621)1 Landers J.E....Brown R.H. (2009)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacks. (PubMed id 17339538)1 Meyers K.J....Kardia S.L. (2007)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Nomenclature of voltage-gated sodium channels. (PubMed id 11144347)1 Goldin A.L....Catterall W.A. (2000)

    External Searches for SCN7A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SCN7A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6332 HGNC: 10594 AceView: SCN7A Ensembl:ENSG00000136546 euGenes: HUgn6332
    ECgene: SCN7A H-InvDB: SCN7A

    Other Databases showing SCN7A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SCN7A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCN7A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SCN7A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SCN7A gene:
    Search GeneIP for patents involving SCN7A

    GeneCards and IP:
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