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Aliases for SCN4B Gene

Aliases for SCN4B Gene

  • Sodium Voltage-Gated Channel Beta Subunit 4 2 3 5
  • Sodium Channel, Voltage-Gated, Type IV, Beta Subunit 2 3
  • Sodium Channel, Voltage Gated, Type IV Beta Subunit 2
  • Sodium Channel, Voltage-Gated, Type IV, Beta 2
  • Sodium Channel Subunit Beta-4 3
  • Navbeta4 3
  • ATFB17 3
  • LQT10 3

External Ids for SCN4B Gene

Previous GeneCards Identifiers for SCN4B Gene

  • GC00U990339
  • GC11U900020
  • GC11M118038
  • GC11M117541
  • GC11M117509
  • GC11M118004
  • GC11M113937

Summaries for SCN4B Gene

Entrez Gene Summary for SCN4B Gene

  • The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]

GeneCards Summary for SCN4B Gene

SCN4B (Sodium Voltage-Gated Channel Beta Subunit 4) is a Protein Coding gene. Diseases associated with SCN4B include Long Qt Syndrome-10 and Familial Atrial Fibrillation. Among its related pathways are G-Beta Gamma Signaling and Cardiac conduction. GO annotations related to this gene include ion channel binding and voltage-gated sodium channel activity. An important paralog of this gene is SCN2B.

UniProtKB/Swiss-Prot for SCN4B Gene

  • Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.

Tocris Summary for SCN4B Gene

  • Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.

Gene Wiki entry for SCN4B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCN4B Gene

Genomics for SCN4B Gene

Regulatory Elements for SCN4B Gene

Enhancers for SCN4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F118082 1.2 Ensembl ENCODE 17.9 +69.0 68989 2.7 HDGF HDAC1 PKNOX1 RARA ZNF766 ZEB2 NR2F2 SMARCA4 PBX2 ETV4 SCN4B TMPRSS13 IL10RA JAML TMPRSS4-AS1 TMPRSS4
GH11F118174 0.8 Ensembl ENCODE 12.6 -22.8 -22764 2.2 ELF3 PKNOX1 ZFP64 RAD21 RFX5 YY1 ZNF366 JUNB CEBPB TBX21 SCN4B SCN2B CD3D CD3G CD3E TMPRSS4 FXYD6 FXYD6-FXYD2 TTC36 GC11P118174
GH11F118273 1.6 FANTOM5 Ensembl ENCODE 12.4 -122.8 -122814 5.3 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 BRCA1 ZNF48 SLC30A9 GLIS2 CD3E MPZL3 SCN4B CD3D CD3G UBE4A ENSG00000271751 JAML MPZL2 FXYD6
GH11F118184 0.8 Ensembl ENCODE 12.3 -32.3 -32286 1.2 NR2F2 SCN2B SCN4B CD3D CD3G CD3E TMPRSS4 HSPE1P18
GH11F118186 0.6 Ensembl 12.3 -34.1 -34086 0.8 SIX4 PKNOX1 ZNF687 ZHX2 DPF2 RAD21 MBD2 CBX1 CTBP1 GATA3 SCN2B SCN4B CD3D CD3G CD3E TMPRSS4 HSPE1P18
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SCN4B on UCSC Golden Path with GeneCards custom track

Promoters for SCN4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001772684 -185 1001 SUZ12 ZNF76 ZIC2 ZNF2 HIC1 ZFHX2 CTBP1 GLIS2 ZBTB48 ZNF366

Genomic Location for SCN4B Gene

Chromosome:
11
Start:
118,133,377 bp from pter
End:
118,152,915 bp from pter
Size:
19,539 bases
Orientation:
Minus strand

Genomic View for SCN4B Gene

Genes around SCN4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCN4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCN4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCN4B Gene

Proteins for SCN4B Gene

  • Protein details for SCN4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWT1-SCN4B_HUMAN
    Recommended name:
    Sodium channel subunit beta-4
    Protein Accession:
    Q8IWT1
    Secondary Accessions:
    • E9PPT5
    • Q6PIG5

    Protein attributes for SCN4B Gene

    Size:
    228 amino acids
    Molecular mass:
    24969 Da
    Quaternary structure:
    • Component of the voltage-sensitive sodium channel complex that consists of an ion-conducting pore-forming alpha subunit and one or more regulatory beta subunits. Heterooligomer with SCN2A; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for SCN4B Gene

    Alternative splice isoforms for SCN4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCN4B Gene

Post-translational modifications for SCN4B Gene

Other Protein References for SCN4B Gene

No data available for DME Specific Peptides for SCN4B Gene

Domains & Families for SCN4B Gene

Protein Domains for SCN4B Gene

Suggested Antigen Peptide Sequences for SCN4B Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWT1

UniProtKB/Swiss-Prot:

SCN4B_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Family:
  • Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family.
genes like me logo Genes that share domains with SCN4B: view

Function for SCN4B Gene

Molecular function for SCN4B Gene

UniProtKB/Swiss-Prot Function:
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.

Gene Ontology (GO) - Molecular Function for SCN4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005248 voltage-gated sodium channel activity IDA 12930796
GO:0005272 sodium channel activity IEA --
GO:0017080 sodium channel regulator activity IDA 17592081
GO:0044325 ion channel binding IPI 17592081
genes like me logo Genes that share ontologies with SCN4B: view
genes like me logo Genes that share phenotypes with SCN4B: view

Human Phenotype Ontology for SCN4B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for SCN4B Gene

miRTarBase miRNAs that target SCN4B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SCN4B Gene

Localization for SCN4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCN4B Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCN4B Gene COMPARTMENTS Subcellular localization image for SCN4B gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SCN4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001518 voltage-gated sodium channel complex IMP 24297919
GO:0005886 plasma membrane IEA --
GO:0014704 intercalated disc ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCN4B: view

Pathways & Interactions for SCN4B Gene

genes like me logo Genes that share pathways with SCN4B: view

Gene Ontology (GO) - Biological Process for SCN4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA,IDA 12930796
GO:0010765 positive regulation of sodium ion transport IDA 17592081
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SCN4B: view

No data available for SIGNOR curated interactions for SCN4B Gene

Drugs & Compounds for SCN4B Gene

(7) Drugs for SCN4B Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma blocker, Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 67
Valproic Acid Approved, Investigational Pharma Target HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 322
Tetrodotoxin Investigational Pharma Channel blocker Na+ channel blocker 4
β-Pompilidotoxin Pharma Slows Na+ channel inactivation 0
QX 314 bromide Pharma Na+ channel blocker 0

(2) Additional Compounds for SCN4B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
Tetrodotoxin citrate
18660-81-6

(5) Tocris Compounds for SCN4B Gene

Compound Action Cas Number
QX 314 bromide Na+ channel blocker 24003-58-5
QX 314 chloride Na+ channel blocker 5369-03-9
Tetrodotoxin Na+ channel blocker 4368-28-9
Tetrodotoxin citrate Na+ channel blocker; citrate salt of tetrodotoxin (Cat. No. 1078) 18660-81-6
Veratridine Voltage-gated Na+ channel opener 71-62-5

(1) ApexBio Compounds for SCN4B Gene

Compound Action Cas Number
β-Pompilidotoxin Slows Na+ channel inactivation 216064-36-7
genes like me logo Genes that share compounds with SCN4B: view

Transcripts for SCN4B Gene

Unigene Clusters for SCN4B Gene

Sodium channel, voltage-gated, type IV, beta subunit:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCN4B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - -
SP2: -
SP3: - - -
SP4: - - - -
SP5:
SP6: - - - - - - -
SP7: -

Relevant External Links for SCN4B Gene

GeneLoc Exon Structure for
SCN4B
ECgene alternative splicing isoforms for
SCN4B

Expression for SCN4B Gene

mRNA expression in normal human tissues for SCN4B Gene

mRNA differential expression in normal tissues according to GTEx for SCN4B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x10.3), Brain - Caudate (basal ganglia) (x7.1), and Brain - Nucleus accumbens (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for SCN4B Gene

This gene is overexpressed in Frontal cortex (29.2), Spinal cord (22.3), and Fetal ovary (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCN4B Gene



Protein tissue co-expression partners for SCN4B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCN4B Gene:

SCN4B

SOURCE GeneReport for Unigene cluster for SCN4B Gene:

Hs.65239

mRNA Expression by UniProt/SwissProt for SCN4B Gene:

Q8IWT1-SCN4B_HUMAN
Tissue specificity: Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.
genes like me logo Genes that share expression patterns with SCN4B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCN4B Gene

Orthologs for SCN4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCN4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCN4B 34 35
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia SCN4B 34 35
  • 88.6 (n)
dog
(Canis familiaris)
Mammalia SCN4B 34 35
  • 86.28 (n)
rat
(Rattus norvegicus)
Mammalia Scn4b 34
  • 83.63 (n)
mouse
(Mus musculus)
Mammalia Scn4b 34 16 35
  • 83.19 (n)
oppossum
(Monodelphis domestica)
Mammalia SCN4B 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCN4B 34 35
  • 70.41 (n)
lizard
(Anolis carolinensis)
Reptilia SCN4B 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scn4b 34
  • 59.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68679 34
zebrafish
(Danio rerio)
Actinopterygii scn4ba 34 35
  • 59.15 (n)
scn4bb 35
  • 42 (a)
OneToMany
Species where no ortholog for SCN4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCN4B Gene

ENSEMBL:
Gene Tree for SCN4B (if available)
TreeFam:
Gene Tree for SCN4B (if available)

Paralogs for SCN4B Gene

Paralogs for SCN4B Gene

genes like me logo Genes that share paralogs with SCN4B: view

Variants for SCN4B Gene

Sequence variations from dbSNP and Humsavar for SCN4B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs121434386 Pathogenic, Long QT syndrome 10 (LQT10) [MIM:611819] 118,141,265(-) TCATC(C/T)TCATC nc-transcript-variant, reference, missense
rs587777559 Atrial fibrillation, familial, 17 (ATFB17) [MIM:611819], Pathogenic 118,141,315(+) GTGTC(A/C)CTGTG nc-transcript-variant, reference, missense
rs587777560 Atrial fibrillation, familial, 17 (ATFB17) [MIM:611819], Pathogenic 118,141,304(+) CAGGA(G/T)GATGA nc-transcript-variant, reference, missense
rs140348243 Likely pathogenic 118,137,097(+) TCCCC(A/G)AGGAG nc-transcript-variant, reference, missense
rs149979176 Likely benign 118,152,656(+) CCTCC(A/G/T)TCCCC reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for SCN4B Gene

Variant ID Type Subtype PubMed ID
esv3627864 CNV loss 21293372
esv3892103 CNV gain 25118596
nsv1049373 CNV loss 25217958
nsv1159938 CNV duplication 26073780
nsv468878 CNV gain 19166990
nsv519116 CNV loss 19592680
nsv556464 CNV gain 21841781

Variation tolerance for SCN4B Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCN4B Gene

Human Gene Mutation Database (HGMD)
SCN4B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCN4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCN4B Gene

Disorders for SCN4B Gene

MalaCards: The human disease database

(9) MalaCards diseases for SCN4B Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
long qt syndrome-10
  • atrial fibrillation, familial, 17
familial atrial fibrillation
  • atrial fibrillation, familial, 1
long qt syndrome 1
  • long qt syndrome 1, acquired
erythromelalgia
  • primary erythermalgia
atrial fibrillation
  • a-fib
- elite association - COSMIC cancer census association via MalaCards
Search SCN4B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SCN4B_HUMAN
  • Atrial fibrillation, familial, 17 (ATFB17) [MIM:611819]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269 PubMed:23604097}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Long QT syndrome 10 (LQT10) [MIM:611819]: A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO:0000269 PubMed:17592081}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SCN4B

Genetic Association Database (GAD)
SCN4B
Human Genome Epidemiology (HuGE) Navigator
SCN4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCN4B
genes like me logo Genes that share disorders with SCN4B: view

No data available for Genatlas for SCN4B Gene

Publications for SCN4B Gene

  1. Mutations of the SCN4B-encoded sodium channel I^4 subunit in familial atrial fibrillation. (PMID: 23604097) Li R.G. … Yang Y.Q. (Int. J. Mol. Med. 2013) 3 4 64
  2. Crystallographic insights into sodium-channel modulation by the beta4 subunit. (PMID: 24297919) Gilchrist J. … Bosmans F. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4 64
  3. Mutations in sodium channel I^-subunit SCN3B are associated with early-onset lone atrial fibrillation. (PMID: 21051419) Olesen M.S. … Svendsen J.H. (Cardiovasc. Res. 2011) 3 4 64
  4. Mutations in sodium channel I^1- and I^2-subunits associated with atrial fibrillation. (PMID: 19808477) Watanabe H. … Roden D.M. (Circ Arrhythm Electrophysiol 2009) 3 46 64
  5. SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome. (PMID: 17592081) Medeiros-Domingo A. … Ackerman M.J. (Circulation 2007) 3 4 64

Products for SCN4B Gene

Sources for SCN4B Gene

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