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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SCN4B Gene

protein-coding GIFtS: 54
GCID: GC11M118004

sodium channel, voltage-gated, type IV, beta subunit

(Previous names: sodium channel, voltage-gated, type IV, beta )

Explore 9 diseases affiliated with
SCN4B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Sodium Channel, Voltage-Gated, Type IV, Beta Subunit¹ ²
LQT10¹ ²
Sodium Channel, Voltage-Gated, Type IV, Beta¹
Navbeta4²
Sodium Channel Subunit Beta-4²

External Ids:	HGNC: 10592¹	Entrez Gene: 6330²	Ensembl: ENSG00000177098⁷	OMIM: 608256⁵	UniProtKB: Q8IWT1³

ORGUL members:
	NONCODE:n407031

Export aliases for SCN4B gene to outside databases

Previous GC identifers: GC00U990339 GC11U900020 GC11M118038 GC11M117541 GC11M117509 GC11M113937

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCN4B:

The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with

voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain

disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding

and one non-coding transcript variant have been found for this gene.(provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: SCN4B_HUMAN, Q8IWT1

Function: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain

alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity)

summary for SCN4B:

Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in

excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low

levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are

composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.

alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.

The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane

potential. S4 is also involved in channel gating.

Gene Wiki entry for SCN4B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SCN4B gene promoter:
AREB6 HEN1 NF-1/L NF-1 p300 LCR-F1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCN4B promoter sequence

Search SABiosciences Chromatin IP Primers for SCN4B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCN4B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3

SCN4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCN4B gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M118004: view genomic region (about GC identifiers)

Start:	118,004,092 bp from pter	End:	118,023,630 bp from pter
Size:	19,539 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SCN4B_HUMAN, Q8IWT1 (See protein sequence)

Recommended Name: Sodium channel subunit beta-4 precursor

Size: 228 amino acids; 24969 Da

Subunit: The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one

or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha,

while beta-2 and beta-4 are covalently linked by disulfide bonds. Associates with SCN2A (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein (Probable)

Sequence caution: Sequence=AAH35017.1; Type=Erroneous initiation;

Secondary accessions: Q6PIG5

Alternative splicing: 2 isoforms: Q8IWT1-1 Q8IWT1-2 (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCN4B: NX_Q8IWT1

Post-translational modifications:

Contains a number of interchain disulfide bonds with SCN2A (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IWT1

SCN4B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001135820.1 NP_001135821.1 NP_777594.1

ENSEMBL proteins:

ENSP00000322460 ENSP00000436343

Human Recombinant Protein Products for SCN4B:

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	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001518	voltage-gated sodium channel complex	IDA	17592081
GO:0005886	plasma membrane	--	--
GO:0014704	intercalated disc	ISS	--

SCN4B for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SCN4B for domains About GeneDecksing

4 InterPro domains/families:

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q8IWT1

ProtoNet protein and cluster: Q8IWT1

UniProtKB/Swiss-Prot: SCN4B_HUMAN, Q8IWT1

Similarity: Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SCN4B_HUMAN, Q8IWT1

Function: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain

alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity)

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005248	voltage-gated sodium channel activity	IDA	12930796
GO:0017080	sodium channel regulator activity	IDA	17592081
GO:0044325	ion channel binding	IPI	17592081
GO:0086006	voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential	IMP	17592081

SCN4B for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN4B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	cAMP Pathway	0.77

Neuropathic Pain-Signaling in Dorsal Horn Neurons

	Neuropathic Pain-Signaling in Dorsal Horn Neurons	1.00			Cholera Infection	0.40
	Aldosterone Signaling in Epithelial Cells	0.47

Antiarrhythmic Pathway, Pharmacodynamics

Antiarrhythmic Pathway, Pharmacodynamics

1.00

SIDS Susceptibility Pathways

SIDS Susceptibility Pathways

1.00

G-Beta Gamma Signaling

GHRH Signaling

0.46

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SCN4B (see all 7)

	Cholera Infection
	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	PKA Signaling
	cAMP Pathway
	Aldosterone Signaling in Epithelial Cells

1 BioSystems Pathway for SCN4B

SIDS Susceptibility Pathways

1 PharmGKB Pathway for SCN4B

Antiarrhythmic Pathway, Pharmacodynamics

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SCN4B

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/13 Interacting proteins for SCN4B (Q8IWT1³ ENSP00000322460⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SCN2A	Q99250³, ENSP00000283256⁴	I2D: score=1 STRING: ENSP00000283256
SCN2B	ENSP00000278947⁴	STRING: ENSP00000278947
SCN3A	ENSP00000283254⁴	STRING: ENSP00000283254
SCN1B	ENSP00000396915⁴	STRING: ENSP00000396915
SCN3B	ENSP00000299333⁴	STRING: ENSP00000299333

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006814	sodium ion transport	IDA	12930796
GO:0010765	positive regulation of sodium ion transport	IDA	17592081
GO:0035725	sodium ion transmembrane transport	IDA	--
GO:0060048	cardiac muscle contraction	IMP	17592081
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	IMP	17592081

SCN4B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for SCN4B available from Tocris Bioscience About this table

Compound	Action	CAS #
Ralfinamide mesylate	Na+ channel blocker	[202825-45-4]
Vinpocetine	Na+ channel blocker	[42971-09-5]
QX 314 chloride	Na+ channel blocker	[5369-03-9]
Flecainide acetate	Cardiac Na+ channel blocker. Antiarrhythmic	[54143-56-5]
Tetrodotoxin citrate	Na+ channel blocker. Citrate salt of tetrodotoxin (Cat. No. 1078)	[18660-81-6]

1 HMDB Compound for SCN4B About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

1 DrugBank Compound for SCN4B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Zonisamide	Zonisamida [Spanish] (see all 2)	68291-97-4	target	inhibitor	20025128 14704463 19557119 18433351 20001433 15511691 19948168

Search CenterWatch for drugs/clinical trials and news about SCN4B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SCN4B gene (3 alternative transcripts):

NM_001142348.1 NM_001142349.1 NM_174934.3

Unigene Cluster for SCN4B:

Sodium channel, voltage-gated, type IV, beta subunit

Hs.65239 [show with all ESTs]

Unigene Representative Sequence: NM_174934

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000415030(uc010rxu.2) ENST00000324727(uc001pse.3 uc010rxv.2)

ENST00000423160 ENST00000531550 ENST00000529878 ENST00000532138

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		hsa-let-7d hsa-miR-15a hsa-miR-139-5p hsa-miR-3916 hsa-miR-570 hsa-miR-890 hsa-let-7g hsa-miR-124

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Additional cDNA sequence:

AK090713.1 AK092285.1 AK124886.1 AK314531.1 AY149967.1 BC035017.2 BX538328.1 NR_024527.1

6 DOTS entries:

DT.100748920 DT.91753667 DT.406411 DT.120708672 DT.120708673 DT.120708658

24/32 AceView cDNA sequences (see all 32):

AW026241 BF958146 BM994844 BM804757 AK092285 BI836997 BX476617 R22665

BM547731 NM_174934 BG702981 AK124886 CB154973 BX538328 BC035017 AI031852

AK090713 AY149967 T33438 T15604 BF943961 BV170797 BX488009 BI755908

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SCN4B (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	·	8e
SP1:					-		-										-
SP2:																	-
SP3:													-		-		-
SP4:			-		-		-										-
SP5:

ECgene alternative splicing isoforms for SCN4B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCN4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTATTCCT

About this image

SCN4B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SCN4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCN4B

SOURCE GeneReport for Unigene cluster: Hs.65239

UniProtKB/Swiss-Prot: SCN4B_HUMAN, Q8IWT1

Tissue specificity: Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal

muscle and heart

SABiosciences Custom PCR Arrays for SCN4B

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN4B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SCN4B gene from 5/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Scn4b^{1 , 5}	sodium channel, type IV, beta^{1, 5}	83.19(n)¹ 79.39(a)¹		9 (24.84 cM)⁵ 399548¹ NM_001013390.2¹ NP_001013408.1¹ 45138437⁵
chicken (Gallus gallus)	Aves	SCN4B¹	sodium channel, voltage-gated, type IV, beta	69.77(n) 59.31(a)		419774 XM_417913.2 XP_417913.2
lizard (Anolis carolinensis)	Reptilia	SCN4B⁶	--	69(a)	1 ↔ 1	AAWZ02039089(5202-7733)
African clawed frog (Xenopus laevis)	Amphibia	MGC68679²	hypothetical protein MGC68679	71.3(n)		BC060028.1
zebrafish (Danio rerio)	Actinopterygii	scn4ba¹	sodium channel, voltage-gated, type IV, beta a	59.15(n) 50.26(a)		566069 NM_001077570.1 NP_001071038.1

ENSEMBL Gene Tree for SCN4B (if available)
TreeFam Gene Tree for SCN4B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SCN4B gene

MPZL2² SCN2B² MPZ² MPZL3² MPZL1²

SCN4B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3741314^1,2	C,F,H	--	113938044(+)	`TGGGAG/AGGTAG`	4	--	nc-transcript-variantut3¹		3	EA NS	1870
rs76776242^1,2	C	--	113938437(+)	`GCCCTC/TGCTCC`	4	--	ut3¹ nc-transcript-variant		2	WA	120
rs45584835^1,2	C,F	--	113938510(+)	`TCTCTA/GACATC`	4	--	ut3¹ nc-transcript-variant		5	NS NA CSA EA	284
rs77548426^1,2	C	--	113938604(+)	`TTGATG/AAGGAG`	4	--	nc-transcript-variantut3¹		2	WA	120
rs868344^1,2	C,F,O,H	--	113938766(+)	`GAAGAC/TAGCTT`	4	--	nc-transcript-variantut3¹		28	NA EA NS CSA	2958
rs11604911^1,2	C,H	--	113938780(+)	`CCATAT/CACATC`	4	--	ut3¹ nc-transcript-variantese³		4	NS EA	416
rs114345754^1,2	C,F	--	113938893(+)	`CCCACG/ACATGG`	4	--	ut3¹ nc-transcript-variant		1	WA	118
rs45460396^1,2	C,F	--	113939269(+)	`NNNNCT/GGAGAG`	4	--	ut3¹ nc-transcript-variant		5	NS NA CSA EA	284
rs7934994^1,2	C,F,H	--	113939427(+)	`ATTGAG/AAAGGA`	4	--	ut3¹ nc-transcript-varianttrp³		11	NS EA NA CSA WA	1212
rs12793713^1,2	H	--	113940113(+)	`CTAGAG/TAGGAT`	4	--	ut3¹ nc-transcript-variantese³		4	NS EA	418

HapMap Linkage Disequilibrium report for SCN4B (118004092 - 118023630 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCN4B: --
Human Gene Mutation Database (HGMD): SCN4B

Locus Specific Mutation Databases (LSDB): SCN4B

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCN4B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SCN4B for disorders           About GeneDecksing

OMIM gene information: 608256
OMIM disorders: 611819
UniProtKB/Swiss-Prot: SCN4B_HUMAN, Q8IWT1

Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart

disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause

syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of

sudden cardiac death in infancy

9 diseases for SCN4B: About MalaCards

long qt syndrome long qt syndrome 10 sudden infant death syndrome congenital heart block

heart block atrial fibrillation erythromelalgia conduction disease

purpura

3 diseases from the University of Copenhagen DISEASES database for SCN4B:

Timothy syndrome Brugada syndrome Long QT syndrome

Human Genome Epidemiology (HuGE) Navigator: SCN4B (4 documents)

Export disorders for SCN4B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SCN4B gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with SCN4B)

Utopia: connect your pdf to the dynamic
world of online information

SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome. (PubMed id 17592081)^{1, 2} Medeiros-Domingo A....Ackerman M.J. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. (PubMed id 12930796)^{1, 2} Yu F.H.... Curtis R. (2003)
A voltage-gated sodium channel is essential for the po sitive selection of CD4(+) T cells. (PubMed id 22842345)¹ Lo W.L....Allen P.M. (2012)
Nav1.7 mutations associated with paroxysmal extreme p ain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurg ent sodium currents. (PubMed id 21115638)¹ Theile J.W....Cummins T.R. (2011)
Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. (PubMed id 20226894)¹ Tan B.H....Ackerman M.J. (2010)
Mutations in sodium channel {beta}-subunit SCN3B are associated with early-onset lone atrial fibrillation. (PubMed id 21051419)¹ Olesen M.S....Svendsen J.H. (2010)
Zonisamide in the treatment of epilepsy. (PubMed id 20001433)⁷ Schulze-Bonhage A. (2010)
The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance. (PubMed id 19948168)⁷ Sonsalla P.K....Buckley B. (2010)
[Role of zonisamid in treating epilepsy, Parkinson di sorders and other neurological diseases]. (PubMed id 20025128)⁷ Janszky J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6330	HGNC: 10592	AceView: SCN4B	Ensembl:ENSG00000177098	euGenes: HUgn6330
ECgene: SCN4B	H-InvDB: SCN4B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SCN4B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SCN4B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SCN4B gene:
Search GeneIP for patents involving SCN4B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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SCN4B Gene

sodium channel, voltage-gated, type IV, beta subunit

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SCN4B Gene

sodium channel, voltage-gated, type IV, beta subunit

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