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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SCN3B Gene

protein-coding GIFtS: 57
GCID: GC11M123533

sodium channel, voltage-gated, type III, beta subunit

(Previous names: sodium channel, voltage-gated, type III, beta )

Explore 7 diseases affiliated with
SCN3B via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sodium Channel, Voltage-Gated, Type III, Beta Subunit¹ ²		Sodium Channel Subunit Beta-3²
HSA243396¹ ²		Voltage-Gated Sodium Channel Beta-3 Subunit²
SCNB3² ⁵		KIAA1158³
Sodium Channel, Voltage-Gated, Type III, Beta¹

External Ids:	HGNC: 20665¹	Entrez Gene: 55800²	Ensembl: ENSG00000166257⁷	OMIM: 608214⁵	UniProtKB: Q9NY72³

Export aliases for SCN3B gene to outside databases

Previous GC identifers: GC11M125013 GC11M123037 GC11M123039 GC11M123005 GC11M119441

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCN3B:

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or

more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons

and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the

inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been

identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SCN3B_HUMAN, Q9NY72

Function: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel

opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the

nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity)

summary for SCN3B:

Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in

excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low

levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are

composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.

alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.

The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane

potential. S4 is also involved in channel gating.

Gene Wiki entry for SCN3B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SCN3B gene promoter:
RP58 LHX3b/Lhx3b p53 HTF NRSF form 1 LHX3a/Lhx3a NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCN3B promoter sequence

Search SABiosciences Chromatin IP Primers for SCN3B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCN3B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q24.1 HGNC cytogenetic band: 11q24.1

SCN3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCN3B gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M123533: view genomic region (about GC identifiers)

Start:	123,499,895 bp from pter	End:	123,525,952 bp from pter
Size:	26,058 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SCN3B_HUMAN, Q9NY72 (See protein sequence)

Recommended Name: Sodium channel subunit beta-3 precursor

Size: 215 amino acids; 24702 Da

Subunit: The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one

or more beta-1, beta-2 and/or beta-3 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while

beta-2 is covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin. Associates with

SCN10A (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

Sequence caution: Sequence=BAA86472.1; Type=Erroneous initiation;

Secondary accessions: A5H1I5 Q17RL3 Q9ULR2

Explore the universe of human proteins at neXtProt for SCN3B: NX_Q9NY72

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NY72

SCN3B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001035241.1 NP_060870.1

ENSEMBL proteins:

ENSP00000376523 ENSP00000432785 ENSP00000435554 ENSP00000434363 ENSP00000299333

Reactome Protein details: Q9NY72
Human Recombinant Protein Products for SCN3B:

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Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001518	voltage-gated sodium channel complex	TAS	--
GO:0005886	plasma membrane	IDA	--
GO:0016021	integral to membrane	NAS	10688874
GO:0030018	Z disc	ISS	--

SCN3B for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SCN3B for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR013783 Ig-like_fold

IPR027096 Na_channel_b3

IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q9NY72

ProtoNet protein and cluster: Q9NY72

2 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: SCN3B_HUMAN, Q9NY72

Similarity: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SCN3B_HUMAN, Q9NY72

Function: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel

opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the

nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity)

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005248	voltage-gated sodium channel activity	NAS	10688874
GO:0017080	sodium channel regulator activity	IMP	--
GO:0044325	ion channel binding	IPI	--
GO:0086006	voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential	IMP	--

SCN3B for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SCN3B:

Synthetic lethal with c-Myc af

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Scn3b):

cardiovascular system

SCN3B for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SCN3B

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN3B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	cAMP Pathway	0.77

Neuropathic Pain-Signaling in Dorsal Horn Neurons

	Neuropathic Pain-Signaling in Dorsal Horn Neurons	1.00			Cholera Infection	0.40
	Aldosterone Signaling in Epithelial Cells	0.47

Interaction between L1 and Ankyrins

Interaction between L1 and Ankyrins

1.00

Antiarrhythmic Pathway, Pharmacodynamics

Antiarrhythmic Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SCN3B (see all 7)

	Cholera Infection
	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	PKA Signaling
	cAMP Pathway
	Aldosterone Signaling in Epithelial Cells

2 BioSystems Pathways for SCN3B

	SIDS Susceptibility Pathways
	Direct p53 effectors

4 Reactome Pathways for SCN3B

	L1CAM interactions
	Developmental Biology
	Interaction between L1 and Ankyrins
	Axon guidance

1 PharmGKB Pathway for SCN3B

Antiarrhythmic Pathway, Pharmacodynamics

SCN3B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SCN3B

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/15 Interacting proteins for SCN3B (Q9NY72³ ENSP00000299333⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFASC	O94856³, ENSP00000353154⁴	I2D: score=1 STRING: ENSP00000353154
TP53	ENSP00000269305⁴	STRING: ENSP00000269305
SCN1B	ENSP00000396915⁴	STRING: ENSP00000396915
SCN2B	ENSP00000278947⁴	STRING: ENSP00000278947
SCN3A	ENSP00000283254⁴	STRING: ENSP00000283254

About this table

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001508	regulation of action potential	--	--
GO:0006814	sodium ion transport	NAS	10688874
GO:0007399	nervous system development	--	--
GO:0007411	axon guidance	TAS	--
GO:0010460	positive regulation of heart rate	ISS	--

SCN3B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for SCN3B available from Tocris Bioscience About this table

Compound	Action	CAS #
Ralfinamide mesylate	Na+ channel blocker	[202825-45-4]
Vinpocetine	Na+ channel blocker	[42971-09-5]
QX 314 chloride	Na+ channel blocker	[5369-03-9]
Flecainide acetate	Cardiac Na+ channel blocker. Antiarrhythmic	[54143-56-5]
Tetrodotoxin citrate	Na+ channel blocker. Citrate salt of tetrodotoxin (Cat. No. 1078)	[18660-81-6]

1 HMDB Compound for SCN3B About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

1 DrugBank Compound for SCN3B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Zonisamide	Zonisamida [Spanish] (see all 2)	68291-97-4	target	inhibitor	20025128 14704463 19557119 18433351 20001433 15511691 19948168

Search CenterWatch for drugs/clinical trials and news about SCN3B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SCN3B gene (2 alternative transcripts):

NM_001040151.1 NM_018400.3

Unigene Cluster for SCN3B:

Sodium channel, voltage-gated, type III, beta subunit

Hs.743255 [show with all ESTs]

Unigene Representative Sequence: NM_018400

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000527125 ENST00000392770(uc001pzb.1) ENST00000530277 ENST00000527836

ENST00000528267 ENST00000299333(uc001pza.1)

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Additional cDNA sequence:

AB032984.1 AJ243396.2 AK055033.1 AK314513.1 AL136589.1 BC045704.1 BC117282.1 BC126265.1

6 DOTS entries:

DT.212253 DT.95262365 DT.100800942 DT.40206695 DT.91746671 DT.95288383

24/91 AceView cDNA sequences (see all 91):

CA392247 AB032984 AL136589 AI304943 CB306778 CB121725 BX106794 BQ776786

BQ776473 BM722078 BM695776 AA134824 T30785 BM691763 BX280396 T30763

AK055033 BE218963 CR609664 AA904010 Z41028 NM_018400 AI497682 BF476778

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCN3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAATAAAGT

About this image

SCN3B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Retina

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SCN3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCN3B

SOURCE GeneReport for Unigene cluster: Hs.743255

SABiosciences Custom PCR Arrays for SCN3B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCN3B Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN3B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SCN3B gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SCN3B¹	sodium channel, voltage-gated, type III, beta	73.18(n) 76.74(a)		419744 XM_417884.3 XP_417884.3
lizard (Anolis carolinensis)	Reptilia	SCN3B⁶	--	72(a)	1 ↔ 1	LGa(3398842-3408368)
zebrafish (Danio rerio)	Actinopterygii	scn3b¹	sodium channel, voltage-gated, type III, beta	59.38(n) 53.49(a)		563935 NM_001080802.1 NP_001074271.1

ENSEMBL Gene Tree for SCN3B (if available)
TreeFam Gene Tree for SCN3B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SCN3B gene

SCN1B²

1 SIMAP similar gene for SCN3B using alignment to 3 protein entries: SCN3B_HUMAN (see all proteins):

SCN1B

SCN3B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121918282^1,2	C,F	pathogenic	125764413(-)	`TCCCCT/CGGCTT`	4	/P /L	mis¹		2	NA EU	5875
rs67630548^1,2	C,F	--	119440667(+)	`GCAGGA/CGATTG`	2	--	ds500¹		2	NA	834
rs112090810^1,2	F	--	119440690(+)	`AATCCC/TGATGA`	2	--	ds500¹		2	CSA	4
rs72552133^1,2	C	--	119440905(+)	`AGTGAC/TTCTTG`	2	--	ds500¹		3	WA	858
rs72552135^1,2	C,F	--	119440958(+)	`GGCTAG/AATCAC`	2	--	ds500¹		2	NA	858
rs67183345^1,2	C	--	119441025(+)	`CCACAG/TATTGG`	2	--	ds500¹		2	WA	740
rs80271418^1,2	F	--	119441028(+)	`CAGATT/CGGGTA`	2	--	ds500¹		1	WA	118
rs72552136^1,2	F	--	119441092(+)	`ACACACTTA/- CTTAG`	2	--	ds500¹		1	--	744
rs72552139^1,2	C,F	--	119441337(+)	`CGTGAC/TGCAGG`	2	--	ut3¹		1	--	738
rs12286568^1,2	C,F,H	--	119441338(+)	`GTGACG/ACAGGG`	2	--	ut3¹ ese³		17	NS EA NA WA	3076

HapMap Linkage Disequilibrium report for SCN3B (123499895 - 123525952 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SCN3B
1 CNV: 3868
Human Gene Mutation Database (HGMD): SCN3B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SCN3B for disorders           About GeneDecksing

OMIM gene information: 608214
OMIM disorders: 613120
UniProtKB/Swiss-Prot: SCN3B_HUMAN, Q9NY72

Defects in SCN3B are the cause of Brugada syndrome type 7 (BRGDA7) [MIM:613120]. A tachyarrhythmia

characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the

ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation

occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not

reset

7 diseases for SCN3B: About MalaCards

sudden infant death syndrome brugada syndrome 7 temporal lobe epilepsy brugada syndrome

atrial fibrillation neuronitis conduction disease

1 disease from the University of Copenhagen DISEASES database for SCN3B:

Brugada syndrome

Human Genome Epidemiology (HuGE) Navigator: SCN3B (7 documents)

Export disorders for SCN3B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SCN3B gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with SCN3B)

Utopia: connect your pdf to the dynamic
world of online information

Beta3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. (PubMed id 10688874)^{1, 2, 3} Morgan K.... Jackson A.P. (2000)
Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibri llation. (PubMed id 20042427)^{1, 2} Valdivia C.R....Makielski J.C. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)^{1, 2} Hirosawa M.... Ohara O. (1999)
Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. (PubMed id 20226894)¹ Tan B.H....Ackerman M.J. (2010)
Mutations in sodium channel {beta}-subunit SCN3B are associated with early-onset lone atrial fibrillation. (PubMed id 21051419)¹ Olesen M.S....Svendsen J.H. (2010)
Functional dominant-negative mutation of sodium chann el subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID p opulation. (PubMed id 20558140)¹ Wang P....Wang Q.K. (2010)
The sodium channel {beta}3-subunit induces multiphasi c gating in NaV1.3 and affects fast inactivation via distinct intracellular reg ions. (PubMed id 20675377)¹ Cusdin F.S....Jackson A.P. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55800	HGNC: 20665	AceView: SCN3B	Ensembl:ENSG00000166257	euGenes: HUgn55800
ECgene: SCN3B	H-InvDB: SCN3B

(According to HUGE)
About This Section

HUGE: KIAA1158

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SCN3B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SCN3B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SCN3B gene:
Search GeneIP for patents involving SCN3B

GeneCards and IP:
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SCN3B Gene

sodium channel, voltage-gated, type III, beta subunit

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SCN3B Gene

sodium channel, voltage-gated, type III, beta subunit

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