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SCN3B Gene

protein-coding   GIFtS: 63
GCID: GC11M123500

Sodium Channel, Voltage-Gated, Type III, Beta Subunit

(Previous names: sodium channel, voltage-gated, type III, beta)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sodium Channel, Voltage-Gated, Type III, Beta Subunit1 2     Sodium Channel Subunit Beta-32
SCNB32 5     Voltage-Gated Sodium Channel Beta-3 Subunit2
Sodium Channel, Voltage-Gated, Type III, Beta1     KIAA11583
HSA2433962     

External Ids:    HGNC: 206651   Entrez Gene: 558002   Ensembl: ENSG000001662577   OMIM: 6082145   UniProtKB: Q9NY723   

Export aliases for SCN3B gene to outside databases

Previous GC identifers: GC11M125013 GC11M123533 GC11M123037 GC11M123039 GC11M123005 GC11M119441


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCN3B Gene:
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one
or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in
neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences
the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein,
have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for SCN3B Gene:
SCN3B (sodium channel, voltage-gated, type III, beta subunit) is a protein-coding gene. Diseases associated with SCN3B include brugada syndrome 7, and brugada syndrome 1. GO annotations related to this gene include ion channel binding and voltage-gated sodium channel activity. An important paralog of this gene is SCN1B.

UniProtKB/Swiss-Prot: SCN3B_HUMAN, Q9NY72
Function: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium
channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium
channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated
axons (By similarity)

summary for SCN3B Gene:
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in
excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low
levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are
composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.
alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.
The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane
potential. S4 is also involved in channel gating.

Gene Wiki entry for SCN3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCN3B gene promoter:
         RP58   LHX3b/Lhx3b   p53   HTF   NRSF form 1   LHX3a/Lhx3a   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCN3B promoter sequence
   Search Chromatin IP Primers for SCN3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCN3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

SCN3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCN3B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M123500:  view genomic region     (about GC identifiers)

Start:
123,499,895 bp from pter      End:
123,525,952 bp from pter
Size:
26,058 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SCN3B_HUMAN, Q9NY72 (See protein sequence)
Recommended Name: Sodium channel subunit beta-3 precursor  
Size: 215 amino acids; 24702 Da
Subunit: The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated
by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated
with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds (By similarity)
Sequence caution: Sequence=BAA86472.1; Type=Erroneous initiation;
Secondary accessions: A5H1I5 Q17RL3 Q9ULR2

Explore the universe of human proteins at neXtProt for SCN3B: NX_Q9NY72

Post-translational modifications: 

  • Glycosylation2 at Asn95, Asn109, Asn113, Asn121
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins (2 alternative transcripts): 
    NP_001035241.1  NP_060870.1  

    ENSEMBL proteins: 
     ENSP00000376523   ENSP00000432785   ENSP00000435554   ENSP00000434363   ENSP00000299333  
    Reactome Protein details: Q9NY72

    SCN3B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SC: Sodium channels
    SCN: Voltage-gated ion channels / Sodium channels
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR027096 Na_channel_b3

    Graphical View of Domain Structure for InterPro Entry Q9NY72

    ProtoNet protein and cluster: Q9NY72

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: SCN3B_HUMAN, Q9NY72
    Similarity: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    SCN3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCN3B_HUMAN, Q9NY72
    Function: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium
    channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium
    channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated
    axons (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005248voltage-gated sodium channel activity NAS10688874
    GO:0005515protein binding ----
    GO:0017080sodium channel regulator activity IMP--
    GO:0044325ion channel binding IPI--
    GO:0086006voltage-gated sodium channel activity involved in cardiac muscle cell action potential IMP--
         
    SCN3B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SCN3B:
     Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Scn3b):
     cardiovascular system 

    SCN3B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCN3B
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    miRNA
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    miRTarBase miRNAs that target SCN3B:
    hsa-mir-335-5p (MIRT018656)

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    Selected qRT-PCR Assays for microRNAs that regulate SCN3B (see all 54):
    hsa-miR-124* hsa-miR-579 hsa-miR-429 hsa-miR-3651 hsa-miR-146a hsa-miR-29a hsa-miR-128 hsa-miR-3170
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCN3B_HUMAN, Q9NY72: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    extracellular1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001518voltage-gated sodium channel complex TAS--
    GO:0005886plasma membrane IDA--
    GO:0016021integral component of membrane NAS10688874
    GO:0030018Z disc ISS--

    SCN3B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SCN3B About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4G-Beta Gamma Signaling
    GHRH Signaling0.46
    5SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SCN3B (see all 7)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    PKA Signaling
    cAMP Pathway
    Aldosterone Signaling in Epithelial Cells

    2 BioSystems Pathways for SCN3B
        SIDS Susceptibility Pathways
    Direct p53 effectors


    1 Reactome Pathway for SCN3B
        Interaction between L1 and Ankyrins

    1 PharmGKB Pathway for SCN3B
        Antiarrhythmic Pathway, Pharmacodynamics


    SCN3B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCN3B
    Interactions:

        Search GeneGlobe Interaction Network for SCN3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for SCN3B (Q9NY723 ENSP000002993334) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFASCO948563, ENSP000003531544I2D: score=1 STRING: ENSP00000353154
    TP53ENSP000002693054STRING: ENSP00000269305
    SCN1BENSP000003969154STRING: ENSP00000396915
    SCN2BENSP000002789474STRING: ENSP00000278947
    SCN3AENSP000002832544STRING: ENSP00000283254
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport NAS10688874
    GO:0007399nervous system development ----
    GO:0007411axon guidance TAS--
    GO:0010460positive regulation of heart rate ISS--
    GO:0010765positive regulation of sodium ion transport IMP--

    SCN3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SCN3B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Phrixotoxin 3 Potent modulator of NaV1.2, NaV1.3 and NaV1.5 channels [880886-00-0]
    QX 314 chlorideNa+ channel blocker[5369-03-9]
    VeratridineVoltage-gated Na+ channel opener[71-62-5]
    TetrodotoxinNa+ channel blocker[4368-28-9]
    Tetrodotoxin citrateNa+ channel blocker. Citrate salt of tetrodotoxin (Cat. No. 1078)[18660-81-6]

    1 HMDB Compound for SCN3B    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for SCN3B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor20025128 14704463 19557119 18433351 20001433 15511691 19948168



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SCN3B gene (2 alternative transcripts): 
    NM_001040151.1  NM_018400.3  

    Unigene Cluster for SCN3B:

    Sodium channel, voltage-gated, type III, beta subunit
    Hs.4865  [show with all ESTs]
    Unigene Representative Sequence: NM_018400
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527125 ENST00000392770(uc001pzb.1) ENST00000530277 ENST00000527836
    ENST00000528267 ENST00000299333(uc001pza.1)
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    hsa-miR-124* hsa-miR-579 hsa-miR-429 hsa-miR-3651 hsa-miR-146a hsa-miR-29a hsa-miR-128 hsa-miR-3170
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    Additional mRNA sequence: 

    AB032984.1 AJ243396.2 AK055033.1 AK314513.1 AL136589.1 BC045704.1 BC117282.1 BC126265.1 

    6 DOTS entries:

    DT.212253  DT.95262365  DT.100800942  DT.40206695  DT.91746671  DT.95288383 

    Selected AceView cDNA sequences (see all 91):

    AI304943 AL136589 T30763 AA976111 BM695776 AA972342 CB306778 BE218963 
    CB121725 BM691763 BX106794 CA392247 AI497682 CR609664 Z41028 BF476778 
    BQ776786 AK055033 AA134824 BQ776473 AA904010 T30785 BM722078 NM_018400 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCN3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATAAAGT
    SCN3B Expression
    About this image


    SCN3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Cerebellum
     
     Lung (Respiratory System)
    SCN3B Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.4865
        Custom PCR Arrays for SCN3B
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    QuantiFast Probe-based Assays in human, mouse, rat SCN3B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SCN3B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scn3b1 , 5 sodium channel, voltage-gated, type III, beta1, 5 89.46(n)1
    97.67(a)1
      9 (21.42 cM)5
    2352811  NM_001083917.11  NP_001077386.11 
     402692175 
    chicken
    (Gallus gallus)
    Aves SCN3B1 sodium channel, voltage-gated, type III, beta subunit 73.18(n)
    76.74(a)
      419744  XM_417884.4  XP_417884.4 
    lizard
    (Anolis carolinensis)
    Reptilia SCN3B6
    sodium channel, voltage-gated, type III, beta subu...
    71(a)
    1 ↔ 1
    LGa(3396216-3426343)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia scn3b1 sodium channel, voltage-gated, type III, beta subunit 65.12(n)
    66.05(a)
      496752  NM_001011299.1  NP_001011299.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scn3b1 sodium channel, voltage-gated, type III, beta 59.38(n)
    53.49(a)
      563935  NM_001080802.1  NP_001074271.1 


    ENSEMBL Gene Tree for SCN3B (if available)
    TreeFam Gene Tree for SCN3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCN3B gene
    SCN1B2  
    1 SIMAP similar gene for SCN3B using alignment to 3 protein entries:     SCN3B_HUMAN (see all proteins):
    SCN1B

    SCN3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SCN3B (see all 688)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355214
    A colorectal cancer sample4--see VAR_0355212 Q L mis40--------
    VAR_0625294
    Brugada syndrome 7 (BRGDA7)4--see VAR_0625292 L P mis40--------
    VAR_0355224
    A colorectal cancer sample4--see VAR_0355222 A T mis40--------
    rs1219182821,2
    C,Fpathogenic1123390923(-) TCCCCT/CGGCTT 4 /P /L mis12Minor allele frequency- C:0.00NA EU 5875
    rs2022476341,2
    C--119448640(+) TTTTTG/TTGAGA 2 -- int10--------
    rs2011100731,2
    --119461597(+) CTCTC-/TGTCTCT 2 -- int10--------
    rs676305481,2
    C,F--123365915(+) GCAGGA/CGATTG 2 -- ds50012Minor allele frequency- C:0.01NA 834
    rs1120908101,2
    F--123365938(+) AATCCC/TGATGA 2 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs11481131,2
    C,F,A,H--123365953(-) TTCTAC/TAAGAA 2 -- ds500115Minor allele frequency- T:0.44NA WA CSA EA 1054
    rs11481121,2
    C,A--123365972(-) AGGCCC/G/TGAAGA 2 -- ds50016NA WA EA 992

    HapMap Linkage Disequilibrium report for SCN3B (123499895 - 123525952 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SCN3B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv443e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): SCN3B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCN3B
    DNA2.0 Custom Variant and Variant Library Synthesis for SCN3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608214   
    OMIM disorders: 613120  
    UniProtKB/Swiss-Prot: SCN3B_HUMAN, Q9NY72
  • Brugada syndrome 7 (BRGDA7) [MIM:613120]: A tachyarrhythmia characterized by right bundle branch block
    and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the
    blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will
    faint and may die in a few minutes if the heart is not reset. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 15 diseases for SCN3B:    
    About MalaCards
    brugada syndrome 7    brugada syndrome 1    brugada syndrome    fainting
    sudden infant death syndrome    temporal lobe epilepsy    cholera    sinusitis
    breast and colorectal cancer    neuronitis    cervicitis    multiple myeloma
    myeloma    colorectal cancer    cerebritis

    1 disease from the University of Copenhagen DISEASES database for SCN3B:
    Brugada syndrome

    SCN3B for disorders           About GeneDecksing

    Genetic Association Database (GAD): SCN3B
    Human Genome Epidemiology (HuGE) Navigator: SCN3B (7 documents)

    Export disorders for SCN3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCN3B gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with SCN3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Beta3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. (PubMed id 10688874)1, 2, 3 Morgan K.... Jackson A.P. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation. (PubMed id 20042427)1, 2 Valdivia C.R.... Makielski J.C. (Cardiovasc. Res. 2010)
    3. Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population. (PubMed id 20558140)1, 4 Wang P....Wang Q.K. (Biochem. Biophys. Res. Commun. 2010)
    4. Mutations in sodium channel I^1- and I^2-subunits associated with atrial fibrillation. (PubMed id 19808477)1, 4 Watanabe H....Roden D.M. (Circ Arrhythm Electrophysiol 2009)
    5. High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts. (PubMed id 16415175)1, 4 Park J.W....Beaty T.H. (J. Med. Genet. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    10. The immunoglobulin domain of the sodium channel I^3 subunit contains a surface-localized disulfide bond that is required for homophilic binding. (PubMed id 23118027)1 Yereddi N.R....Jackson A.P. (FASEB J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55800 HGNC: 20665 AceView: SCN3B Ensembl:ENSG00000166257 euGenes: HUgn55800
    ECgene: SCN3B H-InvDB: SCN3B

    (According to HUGE)
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    HUGE: KIAA1158

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCN3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCN3B gene:
    Search GeneIP for patents involving SCN3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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