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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SCN2B Gene

protein-coding GIFtS: 59
GCID: GC11M118033

sodium channel, voltage-gated, type II, beta subunit

(Previous names: sodium channel, voltage-gated, type II, beta polypeptide,...)

Explore 5 diseases affiliated with
SCN2B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sodium Channel, Voltage-Gated, Type II, Beta Subunit¹ ²
Sodium Channel, Voltage-Gated, Type II, Beta Polypeptide¹ ²
Sodium Channel, Voltage-Gated, Type II, Beta¹
Neuronal Voltage-Gated Sodium Channel Beta 2 Subunit²
Sodium Channel Beta 2 Subunit²
Sodium Channel Subunit Beta-2²

External Ids:	HGNC: 10589¹	Entrez Gene: 6327²	Ensembl: ENSG00000149575⁷	OMIM: 601327⁵	UniProtKB: O60939³

Export aliases for SCN2B gene to outside databases

Previous GC identifers: GC11M120392 GC11M119545 GC11M118070 GC11M117573 GC11M117542 GC11M113967

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SCN2B_HUMAN, O60939

Function: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium

channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli.

Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of

Ranvier (By similarity)

summary for SCN2B:

Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in

excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low

levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are

composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.

alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.

The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane

potential. S4 is also involved in channel gating.

Gene Wiki entry for SCN2B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SCN2B gene promoter:
HEN1 S8 AML1a Pax-2 c-Myb Pax-2a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCN2B promoter sequence

Search SABiosciences Chromatin IP Primers for SCN2B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCN2B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q22-qter

SCN2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCN2B gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M118033: view genomic region (about GC identifiers)

Start:	118,032,666 bp from pter	End:	118,047,388 bp from pter
Size:	14,723 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SCN2B_HUMAN, O60939 (See protein sequence)

Recommended Name: Sodium channel subunit beta-2 precursor

Size: 215 amino acids; 24326 Da

Subunit: The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is

non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A

and TNR (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: O75302 Q9UNN3

Explore the universe of human proteins at neXtProt for SCN2B: NX_O60939

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60939

SCN2B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004579.1

ENSEMBL proteins:

ENSP00000278947

Reactome Protein details: O60939
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001518	voltage-gated sodium channel complex	TAS	9295116

SCN2B for ontologies About GeneDecksing

SCN2B Antibody Products:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SCN2B for domains About GeneDecksing

5 InterPro domains/families:

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR000920 Myelin_P0

Graphical View of Domain Structure for InterPro Entry O60939

ProtoNet protein and cluster: O60939

2 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: SCN2B_HUMAN, O60939

Similarity: Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SCN2B_HUMAN, O60939

Function: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium

channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli.

Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of

Ranvier (By similarity)

Genatlas biochemistry entry for SCN2B:

sodium voltage-gated channel,type II,auxilliary subunit beta homolog to rat contactin,involved in the initiation and

conduction of electrical impulses in nerves,highly similar to myelin protein zero may be involved in demyelinating

diseases,CMT2B excluded

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		8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate SCN2B (see all 94):
		hsa-miR-3194-5p hsa-miR-605 hsa-miR-938 hsa-miR-374a hsa-miR-138-2* hsa-miR-519a hsa-miR-3921 hsa-miR-502-3p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN2B

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005248	voltage-gated sodium channel activity	--	--
GO:0017080	sodium channel regulator activity	IDA	19808477
GO:0086006	voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential	IMP	19808477

SCN2B for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SCN2B:

Decreased cell number

Increased viability after born

Animal Models:
Mouse knock-outs for SCN2B: Scn2b^tm1Lex Scn2b^tm1Isom
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Scn2b):

behavior/neurological

nervous system

SCN2B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	cAMP Pathway	0.77

Neuropathic Pain-Signaling in Dorsal Horn Neurons

	Neuropathic Pain-Signaling in Dorsal Horn Neurons	1.00			Cholera Infection	0.40
	Aldosterone Signaling in Epithelial Cells	0.47

Interaction between L1 and Ankyrins

Interaction between L1 and Ankyrins

1.00

Antiarrhythmic Pathway, Pharmacodynamics

Antiarrhythmic Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SCN2B

Synaptic transmission- ion currents

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SCN2B (see all 7)

	Cholera Infection
	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	PKA Signaling
	cAMP Pathway
	Aldosterone Signaling in Epithelial Cells

4 Reactome Pathways for SCN2B

	L1CAM interactions
	Developmental Biology
	Interaction between L1 and Ankyrins
	Axon guidance

1 PharmGKB Pathway for SCN2B

Antiarrhythmic Pathway, Pharmacodynamics

SCN2B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SCN2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/14 Interacting proteins for SCN2B (ENSP00000278947⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SCN3A	ENSP00000283254⁴	STRING: ENSP00000283254
SCN4B	ENSP00000322460⁴	STRING: ENSP00000322460
SCN1B	ENSP00000396915⁴	STRING: ENSP00000396915
SCN3B	ENSP00000299333⁴	STRING: ENSP00000299333
SCN5A	ENSP00000328968⁴	STRING: ENSP00000328968

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007268	synaptic transmission	TAS	9295116
GO:0007399	nervous system development	IEA	--
GO:0035725	sodium ion transmembrane transport	IDA	19808477
GO:0046684	response to pyrethroid	IEA	--
GO:0060048	cardiac muscle contraction	IMP	19808477

SCN2B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for SCN2B available from Tocris Bioscience About this table

Compound	Action	CAS #
Ralfinamide mesylate	Na+ channel blocker	[202825-45-4]
Vinpocetine	Na+ channel blocker	[42971-09-5]
QX 314 chloride	Na+ channel blocker	[5369-03-9]
Flecainide acetate	Cardiac Na+ channel blocker. Antiarrhythmic	[54143-56-5]
Tetrodotoxin citrate	Na+ channel blocker. Citrate salt of tetrodotoxin (Cat. No. 1078)	[18660-81-6]

1 HMDB Compound for SCN2B About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

1 DrugBank Compound for SCN2B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Zonisamide	Zonisamida [Spanish] (see all 2)	68291-97-4	target	inhibitor	20025128 14704463 19557119 18433351 20001433 15511691 19948168

Search CenterWatch for drugs/clinical trials and news about SCN2B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SCN2B gene:

NM_004588.4

Unigene Cluster for SCN2B:

Sodium channel, voltage-gated, type II, beta subunit

Hs.129783 [show with all ESTs]

Unigene Representative Sequence: NM_004588

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000278947(uc001psf.2)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCN2B
		8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate SCN2B (see all 94):
		hsa-miR-3194-5p hsa-miR-605 hsa-miR-938 hsa-miR-374a hsa-miR-138-2* hsa-miR-519a hsa-miR-3921 hsa-miR-502-3p

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Additional cDNA sequence:

AF007783.1 AF049498.1 AF107028.1 AK090729.1 AK094643.1 AK308834.1 AK313891.1 AY358945.1

BC036793.1 BT019487.1 U87555.1

3 DOTS entries:

DT.111015 DT.100663446 DT.120729655

24/67 AceView cDNA sequences (see all 67):

CR625871 BQ185043 BX953034 CR595040 BX440990 AK094643 F11793 F09443

BQ574152 F05475 F01737 AK090729 T30974 T30988 Z42211 AA453662

F01743 BX953079 BG820853 BM543551 AL523291 AA375154 AW957660 BC036793

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCN2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCTCTCTG

About this image

SCN2B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SCN2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCN2B

SOURCE GeneReport for Unigene cluster: Hs.129783

UniProtKB/Swiss-Prot: SCN2B_HUMAN, O60939

Tissue specificity: Brain specific

SABiosciences Expression via Pathway-Focused PCR Array including SCN2B:

Neuronal Ion Channels in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SCN2B gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SCN2B¹	sodium channel, voltage-gated, type II, beta	77.05(n) 72.56(a)		419776 XM_417914.3 XP_417914.3
lizard (Anolis carolinensis)	Reptilia	SCN2B⁶	--	72(a)	1 ↔ 1	GL343767.1(137038-141430)
zebrafish (Danio rerio)	Actinopterygii	scn2b¹	sodium channel, voltage-gated, type II, beta	60.33(n) 53.66(a)		777666 NM_001077629.1 NP_001071097.1

ENSEMBL Gene Tree for SCN2B (if available)
TreeFam Gene Tree for SCN2B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SCN2B gene

MPZL2² MPZ² MPZL3² MPZL1² SCN4B²

1 SIMAP similar gene for SCN2B using alignment to 2 protein entries: SCN2B_HUMAN (see all proteins):

MPZL2

SCN2B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74674495^1,2	C,	--	118033059(+)	`GGCAGA/GCTCTG`	1	--	ds500¹		3		WA EA	240
rs79269433^1,2	C,	--	118033072(+)	`CAGCTG/CTCATC`	1	--	ds500¹		3		WA EA	240
rs146779747^1,2		--	118033178(+)	`ACAGGA/CAACAT`	1	--	ds500¹		0	--	--	--	--
rs182627244^1,2		--	118033186(+)	`CATCCG/TCATGA`	1	--	ds500¹		0	--	--	--	--
rs140547060^1,2		--	118033395(+)	`CCTCAC/GATGCT`	1	--	ds500¹		0	--	--	--	--
rs145686040^1,2		--	118033415(+)	`GCAGCA/GCCAAT`	1	--	ds500¹		0	--	--	--	--
rs79365909^1,2	F,	--	118033514(+)	`ACACTC/TGAGGG`	1	--	ds500¹		1		EA	120
rs12276389^1,2	C,F,H,	--	118033518(+)	`TCGAGG/AGATTT`	1	--	ds500¹		5		NS EA WA	538
rs625464^1,2	C,F,O,A,H,	--	118033545(-)	`CTGGCG/AACAAT`	1	--	ut3¹		34		MN EA NA NS WA CSA	3051
rs115357119^1,2	C,F,	--	118033560(+)	`CCCAAA/CCAATA`	1	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for SCN2B (118032666 - 118047388 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCN2B: --
Human Gene Mutation Database (HGMD): SCN2B

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCN2B

DNA2.0 Custom Variant and Variant Library Synthesis for SCN2B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SCN2B for disorders           About GeneDecksing

OMIM gene information: 601327    OMIM disorders: --

5 diseases for SCN2B:    About MalaCards

sudden infant death syndrome rasmussen encephalitis generalized epilepsy atrial fibrillation

encephalitis

2 diseases from the University of Copenhagen DISEASES database for SCN2B:

Epilepsy syndrome Brugada syndrome

Human Genome Epidemiology (HuGE) Navigator: SCN2B (7 documents)

Export disorders for SCN2B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SCN2B gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with SCN2B)

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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Evolution and diversity of mammalian sodium channel genes. (PubMed id 10198179)^{1, 3} Plummer N.W. and Meisler M.H. (1999)
Exclusion of the SCN2B gene as candidate for CMT4B. (PubMed id 9887383)^{1, 2} Bolino A.... Devoto M. (1998)
Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel. (PubMed id 9295116)^{1, 2} Eubanks J....Catterall W.A. (1997)
Identification of the cysteine residue responsible for disulfide linkage of Na+ channel alpha and beta2 subunits. (PubMed id 22992729)² Chen C.... Isom L.L. (2012)
Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. (PubMed id 20226894)¹ Tan B.H....Ackerman M.J. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Zonisamide in the treatment of epilepsy. (PubMed id 20001433)⁷ Schulze-Bonhage A. (2010)
The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance. (PubMed id 19948168)⁷ Sonsalla P.K....Buckley B. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6327	HGNC: 10589	AceView: SCN2B	Ensembl:ENSG00000149575	euGenes: HUgn6327
ECgene: SCN2B	H-InvDB: SCN2B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SCN2B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SCN2B gene
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Patent Information for SCN2B gene:
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SCN2B Gene

sodium channel, voltage-gated, type II, beta subunit

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SCN2B Gene

sodium channel, voltage-gated, type II, beta subunit

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