Aliases for SCN2B Gene
- Sodium Channel, Voltage Gated, Type II Beta Subunit 2 3
- Sodium Channel, Voltage-Gated, Type II, Beta Polypeptide 2 3
- Sodium Channel, Voltage-Gated, Type II, Beta Subunit 2 3
- ATFB14 3 6
- Neuronal Voltage-Gated Sodium Channel Beta 2 Subunit 3
- Sodium Channel, Voltage-Gated, Type II, Beta 2
- Sodium Channel Beta 2 Subunit 3
- Sodium Channel Subunit Beta-2 3
External Ids for SCN2B Gene
GeneCards Summary for SCN2B Gene
SCN2B (Sodium Channel, Voltage Gated, Type II Beta Subunit) is a Protein Coding gene. Diseases associated with SCN2B include atrial fibrillation, familial, 14 and atrial fibrillation. Among its related pathways are L1CAM interactions and Activation of cAMP-Dependent PKA. GO annotations related to this gene include sodium channel regulator activity and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. An important paralog of this gene is MPZL1.
UniProtKB/Swiss-Prot for SCN2B Gene
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the voltage sensor and is activated by changes in membrane potential. S4 is also involved in channel gating.