Aliases for SCN2B Gene
External Ids for SCN2B Gene
Previous GeneCards Identifiers for SCN2B Gene
The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]
GeneCards Summary for SCN2B Gene
SCN2B (Sodium Channel, Voltage Gated, Type II Beta Subunit) is a Protein Coding gene. Diseases associated with SCN2B include scn2b-related familial atrial fibrillation and atrial fibrillation, familial, 14. Among its related pathways are Developmental Biology and Activation of cAMP-Dependent PKA. GO annotations related to this gene include sodium channel regulator activity and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. An important paralog of this gene is MPZL1.
UniProtKB/Swiss-Prot for SCN2B Gene
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.