Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCN2B Gene

protein-coding   GIFtS: 59
GCID: GC11M118033

Sodium Channel, Voltage-Gated, Type II, Beta Subunit

(Previous names: sodium channel, voltage-gated, type II, beta polypeptide,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sodium Channel, Voltage-Gated, Type II, Beta Subunit1 2     Neuronal Voltage-Gated Sodium Channel Beta 2 Subunit2
Sodium Channel, Voltage-Gated, Type II, Beta Polypeptide1 2     Sodium Channel Beta 2 Subunit2
Sodium Channel, Voltage-Gated, Type II, Beta1     Sodium Channel Subunit Beta-22
ATFB142     

External Ids:    HGNC: 105891   Entrez Gene: 63272   Ensembl: ENSG000001495757   OMIM: 6013275   UniProtKB: O609393   

Export aliases for SCN2B gene to outside databases

Previous GC identifers: GC11M120392 GC11M119545 GC11M118070 GC11M117573 GC11M117542 GC11M113967


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SCN2B Gene: 
SCN2B (sodium channel, voltage-gated, type II, beta subunit) is a protein-coding gene. Diseases associated with SCN2B include rasmussen encephalitis, and brugada syndrome, and among its related super-pathways are Axon guidance and Activation of cAMP-Dependent PKA. GO annotations related to this gene include voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential and sodium channel regulator activity. An important paralog of this gene is MPZL2.

UniProtKB/Swiss-Prot: SCN2B_HUMAN, O60939
Function: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the
sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into
microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium
channels at nodes of Ranvier (By similarity)

summary for SCN2B Gene:
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in
excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low
levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are
composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.
alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.
The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane
potential. S4 is also involved in channel gating.

Gene Wiki entry for SCN2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCN2B gene promoter:
         HEN1   S8   AML1a   Pax-2   c-Myb   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCN2B promoter sequence
   Search SABiosciences Chromatin IP Primers for SCN2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCN2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

SCN2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCN2B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M118033:  view genomic region     (about GC identifiers)

Start:
118,032,666 bp from pter      End:
118,047,388 bp from pter
Size:
14,723 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SCN2B_HUMAN, O60939 (See protein sequence)
Recommended Name: Sodium channel subunit beta-2 precursor  
Size: 215 amino acids; 24326 Da
Subunit: The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is
non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with
SCN10A and TNR (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O75302 Q9UNN3

Explore the universe of human proteins at neXtProt for SCN2B: NX_O60939

Explore proteomics data for SCN2B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60939

  • SCN2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SCN2B Protein Expression
    REFSEQ proteins: NP_004579.1  
    ENSEMBL proteins: 
     ENSP00000278947  
    Reactome Protein details: O60939
    Human Recombinant Protein Products for SCN2B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SCN2B
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SCN2B
    GenScript Custom Purified and Recombinant Proteins Services for SCN2B
    Novus Biologicals SCN2B Protein
    Novus Biologicals SCN2B Lysate
    Sino Biological Recombinant Protein for SCN2B
    Sino Biological Cell Lysate for SCN2B 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001518voltage-gated sodium channel complex TAS9295116

    SCN2B for ontologies           About GeneDecksing



    SCN2B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SCN2B
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SCN2B
    GenScript Custom Superior Antibodies Services for SCN2B
    Novus Biologicals SCN2B Antibodies
    Search for Antibodies for SCN2B at Abcam
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for SCN2B
    Search LSBio for Antibodies for SCN2B 

    Assay Products for SCN2B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SCN2B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCN2B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SC: Sodium channels
    SCN: Voltage-gated ion channels / Sodium channels
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR000920 Myelin_P0

    Graphical View of Domain Structure for InterPro Entry O60939

    ProtoNet protein and cluster: O60939

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: SCN2B_HUMAN, O60939
    Similarity: Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    SCN2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCN2B_HUMAN, O60939
    Function: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the
    sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into
    microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium
    channels at nodes of Ranvier (By similarity)

         Genatlas biochemistry entry for SCN2B:
    sodium voltage-gated channel,type II,auxilliary subunit beta homolog to rat contactin,involved in the initiation
    and conduction of electrical impulses in nerves,highly similar to myelin protein zero may be involved in
    demyelinating diseases,CMT2B excluded

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005248voltage-gated sodium channel activity ----
    GO:0005515protein binding ----
    GO:0017080sodium channel regulator activity IDA19808477
    GO:0086006voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential IMP19808477
         
    SCN2B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SCN2B:
     Decreased cell number  Increased viability after born 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Scn2b):
     behavior/neurological  nervous system 

    SCN2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SCN2B: Scn2btm1Lex Scn2btm1Isom

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SCN2B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCN2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCN2B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCN2B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCN2B
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate SCN2B (see all 94):
    hsa-miR-3194-5p hsa-miR-605 hsa-miR-938 hsa-miR-374a hsa-miR-138-2* hsa-miR-519a hsa-miR-3921 hsa-miR-502-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SCN2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCN2B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SCN2B
    Sirion Biotech Customized adenovirus for overexpression of SCN2B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SCN2B (see all 7)
    OriGene ORF clones in mouse, rat for SCN2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCN2B (NM_004588)
    Sino Biological Human cDNA Clone for SCN2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCN2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCN2B
    Sirion Biotech Customized lentivirus for stable overexpression of SCN2B 
                         Customized lentivirus expression plasmids for stable overexpression of SCN2B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SCN2B
    Search LifeMap BioReagents cell lines for SCN2B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN2B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SCN2B About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    L1CAM interactions0.39
    Developmental Biology0.69
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4G-Beta Gamma Signaling
    GHRH Signaling0.46
    5Synaptic transmission: ion currents
    Synaptic transmission: ion currents

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SCN2B
        Synaptic transmission- ion currents

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SCN2B (see all 7)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    PKA Signaling
    cAMP Pathway
    Aldosterone Signaling in Epithelial Cells


    4        Reactome Pathways for SCN2B
        L1CAM interactions
    Developmental Biology
    Interaction between L1 and Ankyrins
    Axon guidance

    1 PharmGKB Pathway for SCN2B
        Antiarrhythmic Pathway, Pharmacodynamics


    SCN2B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCN2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for SCN2B (ENSP000002789474) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCN3AENSP000002832544STRING: ENSP00000283254
    SCN4BENSP000003224604STRING: ENSP00000322460
    SCN1BENSP000003969154STRING: ENSP00000396915
    SCN3BENSP000002993334STRING: ENSP00000299333
    SCN5AENSP000003289684STRING: ENSP00000328968
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS9295116
    GO:0007399nervous system development IEA--
    GO:0035725sodium ion transmembrane transport IDA19808477
    GO:0046684response to pyrethroid IEA--
    GO:0060048cardiac muscle contraction IMP19808477

    SCN2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SCN2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Phrixotoxin 3 Potent modulator of NaV1.2, NaV1.3 and NaV1.5 channels [880886-00-0]
    QX 314 chlorideNa+ channel blocker[5369-03-9]
    VeratridineVoltage-gated Na+ channel opener[71-62-5]
    TetrodotoxinNa+ channel blocker[4368-28-9]
    Tetrodotoxin citrateNa+ channel blocker. Citrate salt of tetrodotoxin (Cat. No. 1078)[18660-81-6]

    1 HMDB Compound for SCN2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for SCN2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor20025128 14704463 19557119 18433351 20001433 15511691 19948168

    Search CenterWatch for drugs/clinical trials and news about SCN2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SCN2B gene: 
    NM_004588.4  

    Unigene Cluster for SCN2B:

    Sodium channel, voltage-gated, type II, beta subunit
    Hs.129783  [show with all ESTs]
    Unigene Representative Sequence: NM_004588
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000278947(uc001psf.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCN2B
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate SCN2B (see all 94):
    hsa-miR-3194-5p hsa-miR-605 hsa-miR-938 hsa-miR-374a hsa-miR-138-2* hsa-miR-519a hsa-miR-3921 hsa-miR-502-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SCN2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCN2B
    Clone
    Products:
         
    OriGene clones in human, mouse for SCN2B (see all 7)
    OriGene ORF clones in mouse, rat for SCN2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCN2B (NM_004588)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCN2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCN2B
    Sirion Biotech Customized lentivirus for stable overexpression of SCN2B 
                         Customized lentivirus expression plasmids for stable overexpression of SCN2B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SCN2B
    OriGene qSTAR qPCR primer pairs in human, mouse for SCN2B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCN2B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCN2B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCN2B

    Additional mRNA sequence: 

    AF007783.1 AF049498.1 AF107028.1 AK090729.1 AK094643.1 AK308834.1 AK313891.1 AY358945.1 
    BC036793.1 BT019487.1 U87555.1 

    3 DOTS entries:

    DT.111015  DT.100663446  DT.120729655 

    24/67 AceView cDNA sequences (see all 67):

    BX953079 BX440990 F11793 AK090729 T30988 CR595040 F05475 T30974 
    AA453662 CR625871 Z42211 AK094643 F01737 BX953034 F01743 BQ574152 
    F09443 BQ185043 T65044 AA351683 AL601206 AF049498 AY358945 BG820853 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCN2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTCTCTG
    SCN2B Expression
    About this image


    See SCN2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCN2B

    SOURCE GeneReport for Unigene cluster: Hs.129783

    UniProtKB/Swiss-Prot: SCN2B_HUMAN, O60939
    Tissue specificity: Brain specific

        SABiosciences Expression via Pathway-Focused PCR Array including SCN2B: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SCN2B
    OriGene qSTAR qPCR primer pairs in human, mouse for SCN2B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCN2B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCN2B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCN2B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SCN2B gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scn2b1 , 5 sodium channel, voltage-gated, type II, beta1, 5 87.75(n)1
    92.09(a)1
      9 (24.84 cM)5
    728211  NM_001014761.21  NP_001014761.11 
     451178765 
    chicken
    (Gallus gallus)
    Aves SCN2B1 sodium channel, voltage-gated, type II, beta 77.05(n)
    72.56(a)
      419776  XM_417914.3  XP_417914.3 
    lizard
    (Anolis carolinensis)
    Reptilia SCN2B6
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343767.1(132001-144099)
    zebrafish
    (Danio rerio)
    Actinopterygii scn2b1 sodium channel, voltage-gated, type II, beta 60.33(n)
    53.66(a)
      777666  NM_001077629.1  NP_001071097.1 


    ENSEMBL Gene Tree for SCN2B (if available)
    TreeFam Gene Tree for SCN2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCN2B gene
    MPZL22  MPZ2  MPZL32  MPZL12  SCN4B2  
    1 SIMAP similar gene for SCN2B using alignment to 2 protein entries:     SCN2B_HUMAN (see all proteins):
    MPZL2

    SCN2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/411 SNPs in SCN2B are shown (see all 411)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669176251,2
    C--113968095(+) GAAAG-/TCAG  
            
    CCGAC
    1 -- ut310--------
    rs1877325931,2
    --113982930(+) AGCCTC/TCCAAG 1 -- us2k10--------
    rs746744951,2
    C--118033059(+) GGCAGA/GCTCTG 1 -- ds50013Minor allele frequency- G:0.10WA EA 240
    rs792694331,2
    C--118033072(+) CAGCTG/CTCATC 1 -- ds50013Minor allele frequency- C:0.10WA EA 240
    rs1467797471,2
    --118033178(+) ACAGGA/CAACAT 1 -- ds50010--------
    rs1826272441,2
    C--118033186(+) CATCCG/TCATGA 1 -- ds50010--------
    rs1405470601,2
    C--118033395(+) CCTCAC/GATGCT 1 -- ds50010--------
    rs1456860401,2
    --118033415(+) GCAGCA/GCCAAT 1 -- ds50010--------
    rs793659091,2
    C,F--118033514(+) ACACTC/TGAGGG 1 -- ds50011Minor allele frequency- T:0.03EA 120
    rs122763891,2
    C,F,H--118033518(+) TCGAGG/AGATTT 1 -- ds50015Minor allele frequency- A:0.02NS EA WA 538

    HapMap Linkage Disequilibrium report for SCN2B (118032666 - 118047388 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SCN2B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519116CNV Loss19592680
    nsv898412CNV Gain21882294
    dgv1318n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): SCN2B
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SCN2B
    DNA2.0 Custom Variant and Variant Library Synthesis for SCN2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601327    OMIM disorders: --

    7 diseases for SCN2B:    About MalaCards
    rasmussen encephalitis    brugada syndrome    epilepsy syndrome    sudden infant death syndrome
    encephalitis    cholera    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for SCN2B:
    Epilepsy syndrome     Brugada syndrome

    SCN2B for disorders           About GeneDecksing

    Genetic Association Database (GAD): SCN2B
    Human Genome Epidemiology (HuGE) Navigator: SCN2B (7 documents)

    Export disorders for SCN2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCN2B gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with SCN2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation. (PubMed id 19808477)1, 4 Watanabe H....Roden D.M. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Evolution and diversity of mammalian sodium channel genes. (PubMed id 10198179)1, 3 Plummer N.W. and Meisler M.H. (1999)
    6. Exclusion of the SCN2B gene as candidate for CMT4B. (PubMed id 9887383)1, 2 Bolino A.... Devoto M. (1998)
    7. Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel. (PubMed id 9295116)1, 2 Eubanks J....Catterall W.A. (1997)
    8. Genome-Wide Association Study of Pre-Eclampsia Detects Novel Maternal Single Nucleotide Polymorphisms and Copy-Number Variants in Subs ets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cohort. (PubMed id 23551011)1 Zhao L....Dewan A.T. (2013)
    9. Identification of the cysteine residue responsible for disulfide linkage of Na+ channel alpha and beta2 subunits. (PubMed id 22992729)2 Chen C.... Isom L.L. (2012)
    10. Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. (PubMed id 20226894)1 Tan B.H....Ackerman M.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6327 HGNC: 10589 AceView: SCN2B Ensembl:ENSG00000149575 euGenes: HUgn6327
    ECgene: SCN2B H-InvDB: SCN2B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCN2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCN2B gene:
    Search GeneIP for patents involving SCN2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of SCN2B
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SCN2B  
     OriGene qPCR primer pairs and template standards for SCN2B   OriGene Protein Over-expression Lysate for SCN2B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SCN2B  
     OriGene qSTAR qPCR primer pairs in human, mouse for SCN2B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SCN2B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SCN2B   OriGene Custom Protein Services for SCN2B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCN2B
     QIAGEN SeqTarget long-range PCR primers for resequencing SCN2B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCN2B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCN2B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCN2B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCN2B
     GenScript Custom Purified and Recombinant Proteins Services for SCN2B GenScript cDNA clones with any tag delivered in your preferred vector for SCN2B
     GenScript Custom Assay Services for SCN2B GenScript Custom Superior Antibodies Services for SCN2B
     GenScript Custom overexpressing Cell Line Services for SCN2B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SCN2B promoter
     Search Chromatin IP Primers for SCN2B
     RT2 qPCR Primer Assay in human, mouse, rat SCN2B
     Search GNC Networks for SCN2B
     SABiosciences PCR Arrays including human, mouse, rat SCN2B
     Tocris compounds for SCN2B
     Proteins and Antibodies for SCN2B
     Cell Lysates for SCN2B
     cDNA Clones for SCN2B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SCN2B antibodies
     SCN2B proteins
     SCN2B lysates
     Search for Antibodies for SCN2B at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SCN2B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for SCN2B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN2B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SCN2B
     SwitchGear Promoter luciferase reporter plasmids for SCN2B
     Search ThermoFisher Antibodies for SCN2B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCN2B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SCN2B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCN2B
    Customized:
     lentivirus for stable overexpression of SCN2B
     lentivirus expression plasmids for stable overexpression of SCN2B
     adenovirus for overexpression of SCN2B
     Search LSBio for Antibodies for SCN2B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SCN2B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4