SCN1B Gene
protein-coding GIFtS: 57
GCID: GC19P035521
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sodium channel, voltage-gated, type I, beta subunit(Previous names: sodium channel, voltage-gated, type I, beta polypeptide,...)
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Aliases
for SCN1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sodium Channel, Voltage-Gated, Type I, Beta Subunit1 2 | | GEFSP12 5 | | Sodium Channel, Voltage-Gated, Type I, Beta1 | | Sodium Channel, Voltage-Gated, Type I, Beta Polypeptide1 | | Sodium Channel Beta-1 Subunit2 | | Sodium Channel Subunit Beta-12 |
Export aliases for SCN1B gene to outside databasesPrevious GC identifers: GC19P036139 GC19P035970 GC19P040197 GC19P040213 GC19P032031 |
Summaries
for SCN1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SCN1B:
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of actionpotentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunitprovides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes asodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus,Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms havebeen found for this gene.(provided by RefSeq, Oct 2009)
UniProtKB/Swiss-Prot: SCN1B_HUMAN, Q07699Function: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodiumchannel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Itsassociation with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retainthese channels at the nodes in mature myelinated axonsFunction: Isoform 2: Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding duringbrain development. Stimulates neurite outgrowth
 summary
for SCN1B: Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in
excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low
levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are
composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.
alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.
The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane
potential. S4 is also involved in channel gating.
Gene Wiki entry for SCN1B
|
Genomic Views
for SCN1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCN1B gene promoter:
Elk-1 AML1a POU3F1 Lmo2 XBP-1 Nkx2-5 GATA-2 CREB deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCN1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCN1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.12 HGNC chromosome: 19SCN1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P035521: view genomic region
(about GC identifiers)
Start:
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35,521,592 bp from pter |
End:
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35,531,353 bp from pter |
Size:
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9,762 bases |
Orientation:
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plus strand |
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Proteins
for SCN1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCN1B_HUMAN, Q07699 (See
protein sequence)Recommended Name: Sodium channel subunit beta-1 precursor Size: 218 amino acids; 24707 Da
Subunit: The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by oneor more beta-1, beta-2 and beta-3. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 iscovalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin. Associates with SCN10A (Bysimilarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Secondary accessions: Q5TZZ4 Q6TN97Alternative splicing: 2 isoforms: Q07699-1 Q07699-2 (Due to intron 3 retention)Explore the universe of human proteins at neXtProt for SCN1B: NX_Q07699
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q07699
SCN1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001028.1 NP_950238.1
ENSEMBL proteins: ENSP00000262631 ENSP00000396915 Reactome Protein details: Q07699
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SCN1B for ontologies About GeneDecksing
SCN1B Antibody Products:
Assay Products for SCN1B: |
Protein
Domains /
Families
for SCN1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCN1B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q07699ProtoNet protein and cluster: Q07699 UniProtKB/Swiss-Prot: SCN1B_HUMAN, Q07699Similarity: Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) familySimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain |
Function
for SCN1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SCN1B_HUMAN, Q07699Function: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodiumchannel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Itsassociation with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retainthese channels at the nodes in mature myelinated axonsFunction: Isoform 2: Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding duringbrain development. Stimulates neurite outgrowth Genatlas biochemistry entry for SCN1B:sodium voltage-gated channel,type I,beta 1 subunit,expressed in brain,skeletal muscle,heart,required for normalinactivation kinetics of the Na+ channel
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCN1B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCN1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SCN1B (NM_001037) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCN1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCN1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN1B |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
SCN1B for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for SCN1B: Scn1btm2.1Isom Scn1btm1Isom
7 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Scn1b):
SCN1B for phenotypes About GeneDecksing
|
Pathways & Interactions
for SCN1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | | | 4 | Interaction between L1 and Ankyrins | | | 5 | Antiarrhythmic Pathway, Pharmacodynamics | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SCN1B (see all 7)
4 
Reactome Pathways for SCN1B
1  PharmGKB Pathway for SCN1B
SCN1B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCN1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/18 Interacting proteins for SCN1B (Q076993 ENSP000003969154) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23): About this table
SCN1B for ontologies About GeneDecksing
|
Drugs & Compounds
for SCN1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SCN1B for compounds About GeneDecksing
Compounds for SCN1B available from Tocris Bioscience About this table
1 HMDB Compound for SCN1B About this table
1 DrugBank Compound for SCN1B About this table
3 Novoseek chemical compound relationships for SCN1B gene About this table
Search CenterWatch for drugs/clinical trials and news about SCN1B
|
Transcripts
for SCN1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCN1B gene (2 alternative transcripts): NM_001037.4 NM_199037.3 Unigene Cluster for SCN1B: Sodium channel, voltage-gated, type I, beta subunit Hs.436646 [show with all ESTs]Unigene Representative Sequence: BC1129222 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262631(uc002nxp.3 uc010xsg.2) ENST00000415950(uc002nxo.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCN1B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCN1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SCN1B (NM_001037) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCN1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCN1B |
Additional cDNA sequence: AK295477.1 AK313279.1 AY391842.1 BC021266.2 BC067122.1 BC112922.1 BT019923.1 L10338.1 L16242.1 7 DOTS entries: DT.75189547 DT.443914 DT.75114175 DT.121613012 DT.75102189 DT.95268894 DT.99950036 24/72 AceView cDNA sequences (see all 72): AI492816 BC030193 BM930937 BQ185614 NM_199037 AY391842 AI633649 BI755159 NM_001037 BF725125 R53503 BC067122 BQ187895 CA448248 T29303 BM805468 BQ446734 BU688918 AA505435 BP362210 AA295926 L16242 BC021266 BP348762
GeneLoc Exon Structure
|
Expression
for SCN1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCN1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATAAAGAC
About this image
See SCN1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCN1B
SOURCE GeneReport for Unigene cluster: Hs.436646
UniProtKB/Swiss-Prot: SCN1B_HUMAN, Q07699Tissue specificity: The overall expression of isoforms 1 and 2 is very similar. Isoform 1 is abundantly expressed inskeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very lowlevel in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum,followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to thecerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidalneurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal rootganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level)
SABiosciences Expression via Pathway-Focused PCR Array including SCN1B:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCN1B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN1B |
Orthologs
for SCN1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SCN1B gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for SCN1B (if available)
TreeFam Gene Tree for SCN1B (if available) |
Paralogs
for SCN1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SCN1B gene
- SCN3B2
1 SIMAP similar gene for SCN1B using alignment to 5 protein entries: SCN1B_HUMAN (see all proteins):SCN3B
SCN1B for paralogs About GeneDecksing
|
Genomic Variants
for SCN1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCN1B (35521592 - 35531353 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCN1B: --
Human Gene Mutation Database (HGMD): SCN1B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCN1B |
|
Disorders
/ Diseases
for SCN1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCN1B for disorders About GeneDecksing
OMIM gene information: 600235
OMIM disorders: 604233 612838
UniProtKB/Swiss-Prot: SCN1B_HUMAN, Q07699
Defects in SCN1B are the cause of generalized epilepsy with febrile seizures plus type 1 (GEFS+1)[MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial conditionwith incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimesbeyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures,generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degreeof severity Defects in SCN1B are the cause of Brugada syndrome type 5 (BRGDA5) [MIM:612838]. A tachyarrhythmiacharacterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause theventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situationoccurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is notreset
20/25  diseases for SCN1B (see all 25): About MalaCardsgeneralized epilepsy with febrile seizures plus febrile seizures brugada syndrome 5 generalized epilepsy
brugada syndrome cardiac conduction defect, nonspecific severe myoclonic epilepsy of infancy (smei) seizures
early onset absence epilepsy cardiac conduction defect sudden infant death syndrome dravet syndrome
absence epilepsy temporal lobe epilepsy long qt syndrome idiopathic generalized epilepsy
convulsions atrial fibrillation neuronitis conduction disease
5 diseases from the University of Copenhagen DISEASES database for SCN1B:Idiopathic generalized epilepsy Dravet Syndrome Brugada syndrome Focal epilepsy
Early onset absence epilepsy 9 Novoseek disease relationships for SCN1B gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| epilepsy generalized |
94.6 |
17 |
14738422 (2), 10587582 (1), 11263970 (1), 11690625 (1) (see all 14) |
| seizures febrile |
93.3 |
25 |
14738422 (2), 17020904 (2), 10587582 (1), 11263970 (1) (see all 20) |
| epilepsies myoclonic |
81.3 |
2 |
16806834 (1), 16302874 (1) |
| dravet syndrome |
80.5 |
2 |
19710327 (2), 16302874 (1) |
| familial benign neonatal convulsions |
76.5 |
2 |
10896263 (1), 11579435 (1) |
| epilepsy |
72.5 |
18 |
17020904 (2), 18175077 (1), 19270815 (1), 19522081 (1) (see all 13) |
| absence seizures |
64.9 |
3 |
14504340 (3) |
| epilepsy frontal lobe |
55.1 |
2 |
10896263 (1), 11579435 (1) |
| epilepsy temporal lobe |
45 |
1 |
17020904 (1) |
Genetic Association Database (GAD): SCN1B
Human Genome Epidemiology (HuGE) Navigator: SCN1B (14 documents)
Export disorders for SCN1B gene to outside databases
|
Publications
for SCN1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCN1B gene, integrated from 9 sources (see all 101):
(articles sorted by number of sources associating them with SCN1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The cloning and expression of a sodium channel beta 1-subunit cDNA from human brain. (PubMed id 8394762)1, 2, 3, 9 McClatchey A.I.... Gusella J.F. (1993)
- Genomic organization and chromosomal assignment of the human voltage- gated Na+ channel beta 1 subunit gene (SCN1B). (PubMed id 7851891)1, 2, 9 Makita N....George A.L. Jr. (1994)
- Lack of an association between candidate gene loci and idiopathic generalized epilepsy in Kuwaiti Arab children. (PubMed id 16205844)1, 4, 9 Haider M.Z....Al-Bloushi M. (2005)
- Mutational analysis of the SCN1A, SCN1B and GABRG2 ge nes in 150 Italian patients with idiopathic childhood epilepsies. (PubMed id 19522081)1, 2, 9 Orrico A....Sorrentino V. (2009)
- Febrile seizures and generalized epilepsy associated with a mutation in the Na(+)-channel beta-1 subunit gene SCN1B. (PubMed id 9697698)1, 2, 9 Wallace R.H.... Mulley J.C. (1998)
- New mutation c.374C>T and a putative disease-associated haplotype within SCN1B gene in Tunisian families with febrile seizures. (PubMed id 21040232)1, 2 Fendri-Kriaa N.... Fakhfakh F. (2011)
- Voltage-gated Na+ channel I^1B: a secreted cell adhesi on molecule involved in human epilepsy. (PubMed id 21994374)1, 2 Patino G.A....Isom L.L. (2011)
- Sodium channel beta1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. (PubMed id 18464934)1, 2 Watanabe H.... Bezzina C.R. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit. (PubMed id 14622265)1, 2 Qin N.... Correa A.M. (2003)
|
External Searches for SCN1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCN1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCN1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCN1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SCN1B | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SCN1B |
|
| | |
About This Section
| Patent Information for SCN1B gene:
Search GeneIP for patents involving SCN1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SCN1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCN1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCN1B | | | OriGene Protein Over-expression Lysate for SCN1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SCN1B | | OriGene 3'-UTR Clone for SCN1B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCN1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCN1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SCN1B | | OriGene Custom Protein Services for SCN1B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCN1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCN1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCN1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCN1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCN1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCN1B |
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| | | | Tocris compounds for SCN1B |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN1B |
|  |  |  | | | | ThermoFisher Antibody for SCN1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCN1B |
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