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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCN11A Gene

protein-coding   GIFtS: 51
GCID: GC03M038862

sodium channel, voltage-gated, type XI, alpha subunit

(Previous names: sodium channel, voltage-gated, type XI, alpha polypeptide,...)
(Previous symbol: SCN12A)
 Explore 1 disease affiliated with
SCN11A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SCN11A    

Aliases
for SCN11A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sodium Channel, Voltage-Gated, Type XI, Alpha Subunit1 2     PN52 3
SCN12A1 2 3     HNaN1
NaN1 2     Nav1.91
SNS-21 2     Sodium Channel, Voltage-Gated, Type XII, Alpha1
Sodium Channel, Voltage-Gated, Type XI, Alpha Polypeptide1 2     NAV1.92
Peripheral Nerve Sodium Channel 52 3     Sodium Channel Protein Type 11 Subunit Alpha2
Sensory Neuron Sodium Channel 22 3     Sodium Channel, Voltage-Gated, Type XII, Alpha Polypeptide2
Sodium Channel Protein Type XI Subunit Alpha2 3     Voltage-Gated Sodium Channel Nav1.92
Voltage-Gated Sodium Channel Subunit Alpha Nav1.92 3     SNS23

External Ids:    HGNC: 105831   Entrez Gene: 112802   Ensembl: ENSG000001683567   OMIM: 6043855   UniProtKB: Q9UI333   

Export aliases for SCN11A gene to outside databases

Previous GC identifers: GC03U990114 GC03P038198 GC03M038700 GC03M038847


Summaries
for SCN11A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SCN11A:
Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the
action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and
conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane
localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of
disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6
transmembrane segments and intra- and extracellular linkers.(supplied by OMIM, Apr 2004)

UniProtKB/Swiss-Prot: SCNBA_HUMAN, Q9UI33
Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened
or closed conformations in response to the voltage difference across the membrane, the protein forms a
sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a
tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase
NTRK2, in rapid BDNF-evoked neuronal depolarization

summary for SCN11A:
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in
excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low
levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are
composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.
alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.
The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane
potential. S4 is also involved in channel gating.

Gene Wiki entry for SCN11A (Nav1.9)


Genomic Views
for SCN11A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCN11A gene promoter:
         HFH-3   STAT5B   GR   CUTL1   C/EBPalpha   Evi-1   MEF-2A   FOXI1   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCN11A promoter sequence
   Search SABiosciences Chromatin IP Primers for SCN11A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCN11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.2   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p22.2

SCN11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCN11A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M038862:  view genomic region     (about GC identifiers)

Start:
 38,887,260 bp from pter      End:
 38,992,052 bp from pter
Size:
 104,793 bases      Orientation:
 minus strand

Proteins
for SCN11A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SCNBA_HUMAN, Q9UI33 (See protein sequence)
Recommended Name: Sodium channel protein type 11 subunit alpha  
Size: 1791 amino acids; 204922 Da
Subunit: The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one
or more auxiliary subunits SCN1B, SCN2B and SCN3B
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A6NN05 C9JD48 C9JR31 Q68K15 Q8NDX3 Q9UHE0 Q9UHM0
Alternative splicing: 3 isoforms:  Q9UI33-1   Q9UI33-2   Q9UI33-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCN11A: NX_Q9UI33

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UI33

    • SCN11A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_054858.2  
    ENSEMBL proteins: 
     ENSP00000307599   ENSP00000416757   ENSP00000408028   ENSP00000400945  

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001518voltage-gated sodium channel complex IEA--
    GO:0005886plasma membrane ----
    GO:0030424axon ----
    GO:0044299C-fiber IEA--


    SCN11A for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for SCN11A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SCN11A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001696 Na_channel_asu
     IPR010526 Na_trans_assoc
     IPR005821 Ion_trans_dom

    Graphical View of Domain Structure for InterPro Entry Q9UI33

    ProtoNet protein and cluster: Q9UI33

    1 Blocks protein family: IPB001696 Voltage-gated Na+ channel alpha subunit signature

    UniProtKB/Swiss-Prot: SCNBA_HUMAN, Q9UI33
    Domain: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively
    charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively
    charged amino acids at every third position
    Similarity: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily


    Function
    for SCN11A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SCNBA_HUMAN, Q9UI33
    Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened
    or closed conformations in response to the voltage difference across the membrane, the protein forms a
    sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a
    tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase
    NTRK2, in rapid BDNF-evoked neuronal depolarization

         Genatlas biochemistry entry for SCN11A:
    sodium channel voltage-gated,type XI,alpha polypeptide,preferentially expressed in small diametre sensory neurons of
    dorsal root ganglia and trigeminal ganglia,resistant to tetrodoxin

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCN11A
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SCN11A (see all 15):
    hsa-miR-2052 hsa-miR-98 hsa-let-7d hsa-miR-409-3p hsa-miR-202 hsa-miR-624* hsa-let-7c hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmid: SCN11A 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SCN11A
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005248voltage-gated sodium channel activity IEA--
    GO:0005515protein binding ----


    SCN11A for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for SCN11A: Scn11atm1Mdba Scn11atm1Dgen Scn11atm1Wlf
         3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Scn11a):
     behavior/neurological  integument  nervous system 

    SCN11A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SCN11A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    2Neuropathic Pain-Signaling in Dorsal Horn Neurons
    		Neuropathic Pain-Signaling in Dorsal Horn Neurons1.00
    		Cholera Infection0.40
    		Aldosterone Signaling in Epithelial Cells0.47
    3Synaptic transmission: ion currents
    		Synaptic transmission: ion currents1.00
    4Sodium channels and transporters: inward current
    		Sodium channels and transporters: inward current1.00
    5G-Beta Gamma Signaling
    		GHRH Signaling0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for SCN11A
        Synaptic transmission- ion currents
    Sodium channels and transporters- inward current

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SCN11A (see all 7)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    PKA Signaling
    cAMP Pathway
    Aldosterone Signaling in Epithelial Cells



    SCN11A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCN11A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for SCN11A (ENSP000003075994) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCN10AENSP000003906004STRING: ENSP00000390600
    SCN1AENSP000003645544STRING: ENSP00000364554
    SCN1BENSP000003969154STRING: ENSP00000396915
    SCN2AENSP000002832564STRING: ENSP00000283256
    SCN2BENSP000002789474STRING: ENSP00000278947
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport TAS10623608
    GO:0042493response to drug TAS10623608


    SCN11A for ontologies           About GeneDecksing



    Drugs & Compounds
    for SCN11A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SCN11A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Ralfinamide mesylateNa+ channel blocker[202825-45-4]
    VinpocetineNa+ channel blocker[42971-09-5]
    QX 314 chlorideNa+ channel blocker[5369-03-9]
    Flecainide acetateCardiac Na+ channel blocker. Antiarrhythmic[54143-56-5]
    Tetrodotoxin citrateNa+ channel blocker. Citrate salt of tetrodotoxin (Cat. No. 1078)[18660-81-6]

    1 HMDB Compound for SCN11A    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    2 DrugBank Compounds for SCN11A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor20025128 14704463 19557119 18433351 20001433 15511691 19948168
    Cocaine(âˆ')-cocaine (see all 6)50-36-2targetinhibitor17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about SCN11A / SCNBA 

    Transcripts
    for SCN11A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SCN11A gene: 
    NM_014139.2  

    Unigene Cluster for SCN11A:

    Sodium channel, voltage-gated, type XI, alpha subunit
    Hs.591657  [show with all ESTs]
    Unigene Representative Sequence: AF109737
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302328(uc021wvy.1) ENST00000456224(uc010hhn.1) ENST00000444237(uc003cis.1)
    ENST00000450244

    miRNA
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    hsa-miR-2052 hsa-miR-98 hsa-let-7d hsa-miR-409-3p hsa-miR-202 hsa-miR-624* hsa-let-7c hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmid: SCN11A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCN11A (see all 7)
    OriGene shRNA RFP: SCN11A
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF109737.1 AF150882.1 AF188679.1 AJ417790.1 AY686224.1 

    2 DOTS entries:

    DT.91909186  DT.305032 

    8 AceView cDNA sequences:

    AA913881 AA885211 CD243400 AF109737 NM_014139 AF188679 AY686224 AA913423 

    GeneLoc Exon Structure


    Expression
    for SCN11A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCN11A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTAAATGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SCN11A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCN11A

    SOURCE GeneReport for Unigene cluster: Hs.591657

    UniProtKB/Swiss-Prot: SCNBA_HUMAN, Q9UI33
    Tissue specificity: Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus,
    cerebellar cortex, spinal cord, spleen, small intestine and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including SCN11A: 
              Neuronal Ion Channels in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCN11A

    Orthologs
    for SCN11A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SCN11A gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves E1BXV5_CHICK6
    		 Uncharacterized protein
    		 52(a)
    		 1 ↔ 1
    		 2(5294563-5325348)
    lizard
    (Anolis carolinensis)    		 Reptilia SCN11A6
    		 --
    		 45(a)
    		 1 ↔ 1
    		 6(205770-253425)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01040037.16
    CABZ01063402.16
    (see all 3)    		 --
    		 50(a)
    45(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 2(51470415-51506531)
    24(42714922-42889682)
    fruit fly
    (Drosophila melanogaster)    		 Insecta para6
    		 paralytic
    		 34(a)
    		 1 → many
    		 X(16352900-16421447)


    ENSEMBL Gene Tree for SCN11A (if available)
    TreeFam Gene Tree for SCN11A (if available) 

    Paralogs
    for SCN11A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCN11A gene
    CACNA1A2  SCN5A2  SCN9A2  CACNA1D2  CACNA1I2  SCN7A2  CACNA1F2  SCN8A2  
    CACNA1G2  SCN10A2  SCN3A2  CACNA1E2  SCN2A2  CACNA1S2  CACNA1C2  CACNA1H2  
    SCN4A2  SCN1A2  CACNA1B2  
    11 SIMAP similar genes for SCN11A using alignment to 2 protein entries:     SCNBA_HUMAN (see all proteins):
    SCN4A    SCN5A    SCN10A    SCN1A    SCN2A    SCN9A
    SCN3A    SCN8A    SCN7A    TPCN1    SCN2A2

    SCN11A for paralogs           About GeneDecksing



    Genomic Variants
    for SCN11A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1789 NCBI SNPs in SCN11A are shown (see all 1789)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1816426241,2
    		--38886791(+) ATTCAG/TCCAAA 1 -- ds50010--------
    rs43184941,2
    		C,F,A,--38886804(+) TGTAAG/ATAGGG 1 -- ds500114Minor allele frequency- A:0.49NA WA CSA EA 515
    rs1867066701,2
    		--38886831(+) GATCAC/TTGGTT 1 -- ds50010--------
    rs1466585421,2
    		--38886865(+) CACCCC/TGTGCC 1 -- ds50010--------
    rs772003641,2
    		--38887050(+) TTGATA/TGCTTG 1 -- ds50010--------
    rs1911419581,2
    		--38887073(+) ATGGGA/TGTACT 1 -- ds50010--------
    rs800724311,2
    		F,--38887077(+) GAGTAC/TTCACA 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1458896491,2
    		--38887237(+) AAGGGA/GAATAT 1 -- ds50010--------
    rs67765101,2
    		C,F,A,H,--38887253(+) TACTAT/CCTGAA 1 -- ds500135Minor allele frequency- C:0.37NS EA NA WA CSA 3334
    rs106041421,2
    		C,--38887289(+) GAATTTA/-TATAT 1 -- ut311Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for SCN11A (38887260 - 38992052 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SCN11A
         3 CNVs: 98288 63446 3426
         1 Indel: 27309

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    Disorders / Diseases
    for SCN11A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SCN11A for disorders           About GeneDecksing

    OMIM gene information: 604385    OMIM disorders: --

    1 disease for SCN11A:    About MalaCards
    neuronitis


    Export disorders for SCN11A gene to outside databases

    Publications
    for SCN11A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCN11A gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SCN11A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human voltage-gated sodium channel alpha subunit gene, SCN12A. (PubMed id 10623608)1, 2, 9 Jeong S.-Y.... Kanazawa I. (2000)
    2. International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. (PubMed id 16382098)1, 3 Catterall W.A....Waxman S.G. (2005)
    3. Expression of alternatively spliced sodium channel alpha-subunit genes: unique splicing patterns are observed in dorsal root ganglia. (PubMed id 15302875)1, 2 Raymond C.K.... Johnson J.M. (2004)
    4. Na+ channel Nav1.9: in search of a gating mechanism. (PubMed id 12536125)1, 2 Delmas P. and Coste B. (2003)
    5. Neurotrophin-evoked depolarization requires the sodium channel Nav1.9. (PubMed id 12384689)1, 2 Blum R.... Konnerth A. (2002)
    6. Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN. (PubMed id 10444332)1, 3 Dib-Hajj S.D....Waxman S.G. (1999)
    7. Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons. (PubMed id 10580103)1, 2 Dib-Hajj S.D....Waxman S.G. (1999)
    8. Nav1.9 channel contributes to mechanical and heat pai n hypersensitivity induced by subacute and chronic inflammation. (PubMed id 21857998)1 Lolignier S....Busserolles J. (2011)
    9. Zonisamide in the treatment of epilepsy. (PubMed id 20001433)7 Schulze-Bonhage A. (2010)
    10. The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance. (PubMed id 19948168)7 Sonsalla P.K....Buckley B. (2010)

    External Searches for SCN11A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing SCN11A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11280 HGNC: 10583 AceView: SCN11A Ensembl:ENSG00000168356 euGenes: HUgn11280
    ECgene: SCN11A H-InvDB: SCN11A

    Other Databases showing SCN11A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SCN11A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCN11A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SCN11A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SCN11A gene:
    Search GeneIP for patents involving SCN11A

    GeneCards and IP:
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