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Aliases for SCN10A Gene

Aliases for SCN10A Gene

  • Sodium Channel, Voltage Gated, Type X Alpha Subunit 2 3
  • Sodium Channel, Voltage-Gated, Type X, Alpha Polypeptide 2 3
  • Sodium Channel, Voltage-Gated, Type X, Alpha Subunit 2 3
  • Voltage-Gated Sodium Channel Subunit Alpha Nav1.8 3 4
  • Sodium Channel Protein Type X Subunit Alpha 3 4
  • Peripheral Nerve Sodium Channel 3 3 4
  • FEPS2 3 6
  • HPN3 3 4
  • PN3 3 4
  • Sodium Channel Protein Type 10 Subunit Alpha 3
  • Nav1.8 3
  • SNS 3

External Ids for SCN10A Gene

Summaries for SCN10A Gene

Entrez Gene Summary for SCN10A Gene

  • The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for SCN10A Gene

SCN10A (Sodium Channel, Voltage Gated, Type X Alpha Subunit) is a Protein Coding gene. Diseases associated with SCN10A include episodic pain syndrome, familial, 2 and sodium channelopathy-related small fiber neuropathy. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include voltage-gated sodium channel activity. An important paralog of this gene is CACNA1D.

UniProtKB/Swiss-Prot for SCN10A Gene

  • Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.

Tocris Summary for SCN10A Gene

  • Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the voltage sensor and is activated by changes in membrane potential. S4 is also involved in channel gating.

Gene Wiki entry for SCN10A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCN10A Gene

Genomics for SCN10A Gene

Genomic Location for SCN10A Gene

Start:
38,696,802 bp from pter
End:
38,794,010 bp from pter
Size:
97,209 bases
Orientation:
Minus strand

Genomic View for SCN10A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCN10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCN10A Gene

Regulatory Elements for SCN10A Gene

Proteins for SCN10A Gene

  • Protein details for SCN10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y9-SCNAA_HUMAN
    Recommended name:
    Sodium channel protein type 10 subunit alpha
    Protein Accession:
    Q9Y5Y9
    Secondary Accessions:
    • A6NDQ1

    Protein attributes for SCN10A Gene

    Size:
    1956 amino acids
    Molecular mass:
    220626 Da
    Quaternary structure:
    • The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.

neXtProt entry for SCN10A Gene

Proteomics data for SCN10A Gene at MOPED

Post-translational modifications for SCN10A Gene

  • Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
  • Ubiquitinated by NEDD4L; which promotes its endocytosis.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn284, Asn288, Asn312, Asn335, Asn819, Asn1312, Asn1328, Asn1336, and Asn1686

Other Protein References for SCN10A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCN10A Gene

Domains for SCN10A Gene

Gene Families for SCN10A Gene

HGNC:
  • SC :Sodium channels
  • SCN :Voltage-gated ion channels / Sodium channels
IUPHAR :

Suggested Antigen Peptide Sequences for SCN10A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5Y9

UniProtKB/Swiss-Prot:

SCNAA_HUMAN
Domain:
  • The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position:
    • Q9Y5Y9
  • Contains 1 IQ domain.:
    • Q9Y5Y9
Family:
  • Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.:
    • Q9Y5Y9
genes like me logo Genes that share domains with SCN10A: view

Function for SCN10A Gene

Molecular function for SCN10A Gene

GENATLAS Biochemistry: sodium channel voltage-gated,type X,alpha polypeptide,tetrodotoxin resistant,specific to sensory neurons,expressed in dorsal root ganglia
UniProtKB/Swiss-Prot Function: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.

Gene Ontology (GO) - Molecular Function for SCN10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005248 voltage-gated sodium channel activity IDA 9839820
GO:0044325 ion channel binding IPI 24998131
genes like me logo Genes that share ontologies with SCN10A: view
genes like me logo Genes that share phenotypes with SCN10A: view

Animal Models for SCN10A Gene

MGI Knock Outs for SCN10A:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SCN10A Gene

Localization for SCN10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCN10A Gene

Membrane; Multi-pass membrane protein. Note=It can be translocated to the extracellular membrane through association with S100A10. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCN10A Gene COMPARTMENTS Subcellular localization image for SCN10A gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SCN10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001518 voltage-gated sodium channel complex IDA 9839820
GO:0005886 plasma membrane --
GO:0016020 membrane --
GO:0030424 axon --
GO:0044299 C-fiber IEA --
genes like me logo Genes that share ontologies with SCN10A: view

Pathways for SCN10A Gene

genes like me logo Genes that share pathways with SCN10A: view

Pathways by source for SCN10A Gene

Gene Ontology (GO) - Biological Process for SCN10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002027 regulation of heart rate IMP 20062061
GO:0006811 ion transport --
GO:0006814 sodium ion transport --
GO:0007600 sensory perception TAS 9839820
GO:0019228 neuronal action potential IBA --
genes like me logo Genes that share ontologies with SCN10A: view

Compounds for SCN10A Gene

(5) Tocris Compounds for SCN10A Gene

Compound Action Cas Number
Phrixotoxin 3 Potent modulator of NaV1.2, NaV1.3 and NaV1.5 channels [880886-00-0]
QX 314 chloride Na+ channel blocker [5369-03-9]
Tetrodotoxin Na+ channel blocker [4368-28-9]
Tetrodotoxin citrate Na+ channel blocker. Citrate salt of tetrodotoxin (Cat. No. 1078) [18660-81-6]
Veratridine Voltage-gated Na+ channel opener [71-62-5]

(2) HMDB Compounds for SCN10A Gene

Compound Synonyms Cas Number PubMed IDs
Benzocaine
  • (p-(Ethoxycarbonyl)phenylamine
94-09-7
Sodium
  • Sodium
7440-23-5

(16) Drugbank Compounds for SCN10A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Benzocaine
  • Ethyl Aminobenzoate
94-09-7 target inhibitor
Bupivacaine
  • (+-)-Bupivacaine
2180-92-9 target inhibitor
Chloroprocaine
  • Chloroprocain
133-16-4 target inhibitor
Cocaine
  • (−)-cocaine
50-36-2 target inhibitor
Dibucaine
85-79-0 target inhibitor

(2) IUPHAR Ligand for SCN10A Gene

Ligand Type Action Affinity Pubmed IDs
tetrodotoxin Pore Blocker Antagonist 7.6
batrachotoxin Activator None

(2) Novoseek inferred chemical compound relationships for SCN10A Gene

Compound -log(P) Hits PubMed IDs
tetrodotoxin 62 2
sodium 61.7 11
genes like me logo Genes that share compounds with SCN10A: view

Transcripts for SCN10A Gene

mRNA/cDNA for SCN10A Gene

(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCN10A Gene

Sodium channel, voltage-gated, type X, alpha subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCN10A Gene

No ASD Table

Relevant External Links for SCN10A Gene

GeneLoc Exon Structure for
SCN10A
ECgene alternative splicing isoforms for
SCN10A

Expression for SCN10A Gene

mRNA expression in normal human tissues for SCN10A Gene

mRNA differential expression in normal tissues according to GTEx for SCN10A Gene

This gene is overexpressed in Heart - Left Ventricle (17.9), Testis (11.4), and Heart - Atrial Appendage (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCN10A Gene

SOURCE GeneReport for Unigene cluster for SCN10A Gene Hs.250443

mRNA Expression by UniProt/SwissProt for SCN10A Gene

Q9Y5Y9-SCNAA_HUMAN
Tissue specificity: Expressed in the dorsal root ganglia and sciatic nerve.
genes like me logo Genes that share expressions with SCN10A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCN10A Gene

Orthologs for SCN10A Gene

This gene was present in the common ancestor of animals.

Orthologs for SCN10A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCN10A 35
  • 99.25 (n)
  • 99.28 (a)
SCN10A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCN10A 35
  • 86.75 (n)
  • 85.36 (a)
SCN10A 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCN10A 35
  • 88.82 (n)
  • 88.63 (a)
SCN10A 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scn10a 35
  • 82.37 (n)
  • 82.3 (a)
Scn10a 16
Scn10a 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCN10A 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCN10A 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scn10a 35
  • 82.13 (n)
  • 82.95 (a)
chicken
(Gallus gallus)
Aves SCN10A 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCN10A 36
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01063402.1 36
  • 53 (a)
ManyToMany
scn1a 36
  • 55 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta NaCP60E 37
  • 62 (a)
Species with no ortholog for SCN10A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCN10A Gene

ENSEMBL:
Gene Tree for SCN10A (if available)
TreeFam:
Gene Tree for SCN10A (if available)

Paralogs for SCN10A Gene

Selected SIMAP similar genes for SCN10A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCN10A: view

Variants for SCN10A Gene

Sequence variations from dbSNP and Humsavar for SCN10A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3923696 -- 38,740,702(+) TGATG(A/T)TAACC intron-variant
rs3923697 -- 38,741,079(+) ATGGC(A/G)GAGGG intron-variant
rs4072089 -- 38,773,743(+) AGTCA(C/T)ACAAT intron-variant
rs4072090 -- 38,773,939(+) TATCA(G/T)AAGAC intron-variant
rs4076737 -- 38,723,291(-) GCGCC(A/C)GCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCN10A Gene

Variant ID Type Subtype PubMed ID
nsv527515 CNV Loss 19592680

Relevant External Links for SCN10A Gene

HapMap Linkage Disequilibrium report
SCN10A
Human Gene Mutation Database (HGMD)
SCN10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCN10A Gene

Disorders for SCN10A Gene

(1) OMIM Diseases for SCN10A Gene (604427)

UniProtKB/Swiss-Prot

SCNAA_HUMAN
  • Episodic pain syndrome, familial, 2 (FEPS2) [MIM:615551]: An autosomal dominant neurologic disorder characterized by adult-onset of paroxysmal pain mainly affecting the distal lower extremities. {ECO:0000269 PubMed:23115331}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for SCN10A Gene

Relevant External Links for SCN10A

Genetic Association Database (GAD)
SCN10A
Human Genome Epidemiology (HuGE) Navigator
SCN10A
genes like me logo Genes that share disorders with SCN10A: view

Publications for SCN10A Gene

  1. A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. (PMID: 9839820) Rabert D.K. … Sangameswaran L. (Pain 1998) 2 3 4 23
  2. International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. (PMID: 16382098) Catterall W.A. … Waxman S.G. (Pharmacol. Rev. 2005) 2 3
  3. Gain-of-function Nav1.8 mutations in painful neuropathy. (PMID: 23115331) Faber C.G. … Waxman S.G. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4
  4. Genome-wide association study of PR interval. (PMID: 20062060) Pfeufer A. … Heckbert S.R. (Nat. Genet. 2010) 3 48
  5. Genetic variation in SCN10A influences cardiac conduction. (PMID: 20062061) Chambers J.C. … Kooner J.S. (Nat. Genet. 2010) 3 48

Products for SCN10A Gene

Sources for SCN10A Gene

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