Aliases for SCN10A Gene
- Sodium Channel, Voltage Gated, Type X Alpha Subunit 2 3
- Sodium Channel, Voltage-Gated, Type X, Alpha Polypeptide 2 3
- Sodium Channel, Voltage-Gated, Type X, Alpha Subunit 2 3
- Voltage-Gated Sodium Channel Subunit Alpha Nav1.8 3 4
- Sodium Channel Protein Type X Subunit Alpha 3 4
- Peripheral Nerve Sodium Channel 3 3 4
- FEPS2 3 6
External Ids for SCN10A Gene
Previous GeneCards Identifiers for SCN10A Gene
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for SCN10A Gene
SCN10A (Sodium Channel, Voltage Gated, Type X Alpha Subunit) is a Protein Coding gene. Diseases associated with SCN10A include episodic pain syndrome, familial, 2 and sodium channelopathy-related small fiber neuropathy. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include voltage-gated sodium channel activity. An important paralog of this gene is CACNA1D.
UniProtKB/Swiss-Prot for SCN10A Gene
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane potential. S4 is also involved in channel gating.