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Aliases for SCN10A Gene

Aliases for SCN10A Gene

  • Sodium Voltage-Gated Channel Alpha Subunit 10 2 3
  • Sodium Channel, Voltage Gated, Type X Alpha Subunit 2 3 5
  • Sodium Channel, Voltage-Gated, Type X, Alpha Polypeptide 2 3
  • Sodium Channel, Voltage-Gated, Type X, Alpha Subunit 2 3
  • Voltage-Gated Sodium Channel Subunit Alpha Nav1.8 3 4
  • Sodium Channel Protein Type X Subunit Alpha 3 4
  • Peripheral Nerve Sodium Channel 3 3 4
  • HPN3 3 4
  • PN3 3 4
  • Nav1.8 3
  • FEPS2 3
  • SNS 3

External Ids for SCN10A Gene

Previous GeneCards Identifiers for SCN10A Gene

  • GC03U990071
  • GC03M038552
  • GC03M038699

Summaries for SCN10A Gene

Entrez Gene Summary for SCN10A Gene

  • The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for SCN10A Gene

SCN10A (Sodium Voltage-Gated Channel Alpha Subunit 10) is a Protein Coding gene. Diseases associated with SCN10A include Episodic Pain Syndrome, Familial, 2 and Erythromelalgia. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. GO annotations related to this gene include ion channel activity and voltage-gated sodium channel activity. An important paralog of this gene is CACNA1G.

UniProtKB/Swiss-Prot for SCN10A Gene

  • Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.

Tocris Summary for SCN10A Gene

  • Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.

Gene Wiki entry for SCN10A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCN10A Gene

Genomics for SCN10A Gene

Regulatory Elements for SCN10A Gene

Enhancers for SCN10A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCN10A on UCSC Golden Path with GeneCards custom track

Genomic Location for SCN10A Gene

Chromosome:
3
Start:
38,696,802 bp from pter
End:
38,794,010 bp from pter
Size:
97,209 bases
Orientation:
Minus strand

Genomic View for SCN10A Gene

Genes around SCN10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCN10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCN10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCN10A Gene

Proteins for SCN10A Gene

  • Protein details for SCN10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y9-SCNAA_HUMAN
    Recommended name:
    Sodium channel protein type 10 subunit alpha
    Protein Accession:
    Q9Y5Y9
    Secondary Accessions:
    • A6NDQ1

    Protein attributes for SCN10A Gene

    Size:
    1956 amino acids
    Molecular mass:
    220626 Da
    Quaternary structure:
    • The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.

neXtProt entry for SCN10A Gene

Proteomics data for SCN10A Gene at MOPED

Post-translational modifications for SCN10A Gene

  • Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
  • Ubiquitinated by NEDD4L; which promotes its endocytosis.
  • Glycosylation at Asn 284, Asn 288, Asn 312, Asn 335, Asn 819, Asn 1312, Asn 1328, Asn 1336, and Asn 1686
  • Modification sites at PhosphoSitePlus

Other Protein References for SCN10A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SCN10A (SCN10A)

No data available for DME Specific Peptides for SCN10A Gene

Domains & Families for SCN10A Gene

Gene Families for SCN10A Gene

Suggested Antigen Peptide Sequences for SCN10A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5Y9

UniProtKB/Swiss-Prot:

SCNAA_HUMAN :
  • The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
  • Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
Domain:
  • The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
  • Contains 1 IQ domain.
Family:
  • Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
genes like me logo Genes that share domains with SCN10A: view

Function for SCN10A Gene

Molecular function for SCN10A Gene

GENATLAS Biochemistry:
sodium channel voltage-gated,type X,alpha polypeptide,tetrodotoxin resistant,specific to sensory neurons,expressed in dorsal root ganglia
UniProtKB/Swiss-Prot Function:
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
genes like me logo Genes that share phenotypes with SCN10A: view

Human Phenotype Ontology for SCN10A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SCN10A Gene

MGI Knock Outs for SCN10A:

Animal Model Products

  • Taconic Biosciences Mouse Models for SCN10A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for SCN10A Gene

Localization for SCN10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCN10A Gene

Membrane; Multi-pass membrane protein. Note=It can be translocated to the extracellular membrane through association with S100A10. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCN10A Gene COMPARTMENTS Subcellular localization image for SCN10A gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for SCN10A Gene

Pathways & Interactions for SCN10A Gene

genes like me logo Genes that share pathways with SCN10A: view

Pathways by source for SCN10A Gene

Gene Ontology (GO) - Biological Process for SCN10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0007600 sensory perception TAS 9839820
GO:0019228 neuronal action potential IBA --
GO:0019233 sensory perception of pain IEA --
genes like me logo Genes that share ontologies with SCN10A: view

No data available for SIGNOR curated interactions for SCN10A Gene

Drugs & Compounds for SCN10A Gene

(23) Drugs for SCN10A Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benzocaine Approved Pharma blocker, Target, inhibitor 1733
Bupivacaine Approved, Investigational Pharma Pore Blocker, blocker, Target, inhibitor 1010
Chloroprocaine Approved Pharma blocker, Target, inhibitor 16
Cocaine Approved, Illicit Pharma inhibitor, Target 464
Dibucaine Approved Pharma blocker, Target, inhibitor 0

(4) Additional Compounds for SCN10A Gene - From: Tocris, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
Amiloride hydrochloride
2016-88-8
Flunarizine dihydrochloride
30484-77-6
Riluzole hydrochloride
850608-87-6

(5) Tocris Compounds for SCN10A Gene

Compound Action Cas Number
Amiloride hydrochloride Na+ channel blocker; also I2 imidazoline ligand 2016-88-8
Flunarizine dihydrochloride Dual Na+/Ca2+ channel (T-type) blocker 30484-77-6
Riluzole hydrochloride Glutamate release inhibitor/GABA uptake inhibitor 850608-87-6
Veratridine Voltage-gated Na+ channel opener 71-62-5
Vinpocetine Na+ channel blocker 42971-09-5
genes like me logo Genes that share compounds with SCN10A: view

Transcripts for SCN10A Gene

mRNA/cDNA for SCN10A Gene

(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCN10A Gene

Sodium channel, voltage-gated, type X, alpha subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCN10A Gene

No ASD Table

Relevant External Links for SCN10A Gene

GeneLoc Exon Structure for
SCN10A
ECgene alternative splicing isoforms for
SCN10A

Expression for SCN10A Gene

mRNA expression in normal human tissues for SCN10A Gene

mRNA differential expression in normal tissues according to GTEx for SCN10A Gene

This gene is overexpressed in Heart - Left Ventricle (x17.9), Testis (x11.4), and Heart - Atrial Appendage (x7.8).

Protein differential expression in normal tissues from HIPED for SCN10A Gene

This gene is overexpressed in Monocytes (22.5), Tlymphocyte (18.7), Blymphocyte (17.3), and Neutrophil (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCN10A Gene



SOURCE GeneReport for Unigene cluster for SCN10A Gene Hs.250443

mRNA Expression by UniProt/SwissProt for SCN10A Gene

Q9Y5Y9-SCNAA_HUMAN
Tissue specificity: Expressed in the dorsal root ganglia and sciatic nerve.
genes like me logo Genes that share expression patterns with SCN10A: view

Protein tissue co-expression partners for SCN10A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCN10A Gene

Orthologs for SCN10A Gene

This gene was present in the common ancestor of animals.

Orthologs for SCN10A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCN10A 35
  • 86.75 (n)
  • 85.36 (a)
SCN10A 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCN10A 35
  • 88.82 (n)
  • 88.63 (a)
SCN10A 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scn10a 35
  • 82.37 (n)
  • 82.3 (a)
Scn10a 16
Scn10a 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCN10A 35
  • 99.25 (n)
  • 99.28 (a)
SCN10A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scn10a 35
  • 82.13 (n)
  • 82.95 (a)
oppossum
(Monodelphis domestica)
Mammalia SCN10A 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCN10A 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCN10A 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCN10A 36
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01063402.1 36
  • 53 (a)
ManyToMany
scn1a 36
  • 55 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta NaCP60E 37
  • 62 (a)
Species with no ortholog for SCN10A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCN10A Gene

ENSEMBL:
Gene Tree for SCN10A (if available)
TreeFam:
Gene Tree for SCN10A (if available)

Paralogs for SCN10A Gene

(11) SIMAP similar genes for SCN10A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCN10A: view

Variants for SCN10A Gene

Sequence variations from dbSNP and Humsavar for SCN10A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7630989 - 38,752,449(+) AGGGG(A/G)CCGGA intron-variant, reference, missense
rs6795970 - 38,725,184(+) CAGGG(A/G)CCTGA reference, missense
rs12632942 - 38,723,507(+) GATCT(A/G)GGCAG reference, missense
rs6599241 - 38,698,083(+) GACCA(C/T)GATGA reference, missense
rs35332705 - 38,750,172(+) TTGTC(C/T)TGCAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SCN10A Gene

Variant ID Type Subtype PubMed ID
nsv527515 CNV Loss 19592680

Variation tolerance for SCN10A Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.59; 82.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCN10A Gene

Human Gene Mutation Database (HGMD)
SCN10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCN10A Gene

Disorders for SCN10A Gene

MalaCards: The human disease database

(21) MalaCards diseases for SCN10A Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
episodic pain syndrome, familial, 2
  • familial episodic pain syndrome 2
erythromelalgia
  • mitchell disease
penile cancer
  • ca penis
paroxysmal extreme pain disorder
  • familial rectal pain
episodic pain syndrome, familial
  • familial episodic pain syndrome
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SCNAA_HUMAN
  • Episodic pain syndrome, familial, 2 (FEPS2) [MIM:615551]: An autosomal dominant neurologic disorder characterized by adult-onset of paroxysmal pain mainly affecting the distal lower extremities. {ECO:0000269 PubMed:23115331}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SCN10A

Genetic Association Database (GAD)
SCN10A
Human Genome Epidemiology (HuGE) Navigator
SCN10A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCN10A
genes like me logo Genes that share disorders with SCN10A: view

No data available for Genatlas for SCN10A Gene

Publications for SCN10A Gene

  1. A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. (PMID: 9839820) Rabert D.K. … Sangameswaran L. (Pain 1998) 2 3 4 23 67
  2. Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. (PMID: 20044988) Leffler A. … Nau C. (Eur. J. Pharmacol. 2010) 25 26
  3. Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. (PMID: 20585544) Karoly R. … Mike A. (PLoS Comput. Biol. 2010) 25 26
  4. Sodium channel molecular conformations and antiarrhythmic drug affinity. (PMID: 20685573) Sheets M.F. … Hanck D.A. (Trends Cardiovasc. Med. 2010) 25 26
  5. Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. (PMID: 19088384) Muroi Y. … Chanda B. (J. Gen. Physiol. 2009) 25 26

Products for SCN10A Gene

Sources for SCN10A Gene

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