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Aliases for SCML4 Gene

Aliases for SCML4 Gene

  • Sex Comb On Midleg-Like 4 (Drosophila) 2 3
  • Sex Comb On Midleg-Like Protein 4 3
  • DJ47M23.1 3

External Ids for SCML4 Gene

Previous GeneCards Identifiers for SCML4 Gene

  • GC06M108025
  • GC06M108070
  • GC06M108071
  • GC06M108146
  • GC06M105595
  • GC06M108023

Summaries for SCML4 Gene

GeneCards Summary for SCML4 Gene

SCML4 (Sex Comb On Midleg-Like 4 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is SCMH1.

UniProtKB/Swiss-Prot for SCML4 Gene

  • Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCML4 Gene

Genomics for SCML4 Gene

Regulatory Elements for SCML4 Gene

Genomic Location for SCML4 Gene

Start:
107,702,157 bp from pter
End:
107,824,403 bp from pter
Size:
122,247 bases
Orientation:
Minus strand

Genomic View for SCML4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCML4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCML4 Gene

Proteins for SCML4 Gene

  • Protein details for SCML4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N228-SCML4_HUMAN
    Recommended name:
    Sex comb on midleg-like protein 4
    Protein Accession:
    Q8N228
    Secondary Accessions:
    • B0QZ10
    • B0QZ11
    • B7ZBX3
    • Q5JXD0
    • Q5T0T6
    • Q8IYY6

    Protein attributes for SCML4 Gene

    Size:
    414 amino acids
    Molecular mass:
    45023 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCML4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCML4 Gene

Proteomics data for SCML4 Gene at MOPED

Post-translational modifications for SCML4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCML4 Gene

Domains for SCML4 Gene

Gene Families for SCML4 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for SCML4 Gene

Suggested Antigen Peptide Sequences for SCML4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N228

UniProtKB/Swiss-Prot:

SCML4_HUMAN :
  • Q8N228
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the SCM family.
genes like me logo Genes that share domains with SCML4: view

Function for SCML4 Gene

Molecular function for SCML4 Gene

UniProtKB/Swiss-Prot Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).

Gene Ontology (GO) - Molecular Function for SCML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SCML4: view

Phenotypes for SCML4 Gene

GenomeRNAi human phenotypes for SCML4:
genes like me logo Genes that share phenotypes with SCML4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SCML4 Gene

Localization for SCML4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCML4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCML4 Gene COMPARTMENTS Subcellular localization image for SCML4 gene
Compartment Confidence
nucleus 4
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SCML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SCML4: view

Pathways for SCML4 Gene

SuperPathways for SCML4 Gene

No Data Available

Interacting Proteins for SCML4 Gene

Gene Ontology (GO) - Biological Process for SCML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SCML4: view

No data available for Pathways by source for SCML4 Gene

Transcripts for SCML4 Gene

Unigene Clusters for SCML4 Gene

Sex comb on midleg-like 4 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCML4 Gene

No ASD Table

Relevant External Links for SCML4 Gene

GeneLoc Exon Structure for
SCML4
ECgene alternative splicing isoforms for
SCML4

Expression for SCML4 Gene

mRNA expression in normal human tissues for SCML4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCML4 Gene

This gene is overexpressed in Whole Blood (14.2), Small Intestine - Terminal Ileum (7.2), and Spleen (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCML4 Gene

SOURCE GeneReport for Unigene cluster for SCML4 Gene Hs.486109

genes like me logo Genes that share expressions with SCML4: view

No data available for mRNA Expression by UniProt/SwissProt for SCML4 Gene

Orthologs for SCML4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCML4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCML4 35
  • 99.52 (n)
  • 99.28 (a)
SCML4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCML4 35
  • 85.85 (n)
  • 85.47 (a)
SCML4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCML4 35
  • 89.05 (n)
  • 91.06 (a)
SCML4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scml4 35
  • 81.54 (n)
  • 80.15 (a)
Scml4 16
Scml4 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCML4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 17 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Scml4 35
  • 79.92 (n)
  • 78.1 (a)
chicken
(Gallus gallus)
Aves SCML4 35
  • 72 (n)
  • 70.69 (a)
SCML4 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCML4 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scml4 35
  • 72.11 (n)
  • 76.73 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC794170 35
  • 64.7 (n)
  • 64.78 (a)
scml4 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta l(3)mbt 36
  • 4 (a)
OneToMany
Species with no ortholog for SCML4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCML4 Gene

ENSEMBL:
Gene Tree for SCML4 (if available)
TreeFam:
Gene Tree for SCML4 (if available)

Paralogs for SCML4 Gene

Selected SIMAP similar genes for SCML4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCML4: view

Variants for SCML4 Gene

Sequence variations from dbSNP and Humsavar for SCML4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs764540 -- 107,703,627(+) TACAA(A/C)GGCAG utr-variant-3-prime
rs846976 -- 107,720,001(+) CAACA(A/C)GCTTT intron-variant
rs846977 -- 107,721,009(-) CTGTA(C/T)TGCCT intron-variant
rs846978 -- 107,721,130(+) GAACC(C/T)CACAA intron-variant
rs846979 -- 107,722,053(+) GGTGC(A/G)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCML4 Gene

Variant ID Type Subtype PubMed ID
nsv830763 CNV Gain 17160897
nsv830764 CNV Gain 17160897
esv23033 CNV Gain 19812545
esv2640753 CNV Deletion 19546169
nsv511910 CNV Loss 21212237
esv2057606 CNV Deletion 18987734
esv2732553 CNV Deletion 23290073
esv6501 CNV Loss 19470904
nsv349488 CNV Loss 16902084
nsv820392 CNV Deletion 20802225
esv1367877 CNV Deletion 17803354
nsv830765 CNV Loss 17160897
esv2660523 CNV Deletion 23128226

Relevant External Links for SCML4 Gene

HapMap Linkage Disequilibrium report
SCML4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCML4 Gene

Disorders for SCML4 Gene

Relevant External Links for SCML4

Genetic Association Database (GAD)
SCML4
Human Genome Epidemiology (HuGE) Navigator
SCML4
genes like me logo Genes that share disorders with SCML4: view

No data available for UniProtKB/Swiss-Prot for SCML4 Gene

Publications for SCML4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 48
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4

Products for SCML4 Gene

Sources for SCML4 Gene

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