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Aliases for SCML4 Gene

Aliases for SCML4 Gene

  • Sex Comb On Midleg-Like 4 (Drosophila) 2 3
  • DJ47M23.1 3

External Ids for SCML4 Gene

Previous GeneCards Identifiers for SCML4 Gene

  • GC06M108025
  • GC06M108070
  • GC06M108071
  • GC06M108146
  • GC06M105595
  • GC06M108023

Summaries for SCML4 Gene

GeneCards Summary for SCML4 Gene

SCML4 (Sex Comb On Midleg-Like 4 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is SCMH1.

UniProtKB/Swiss-Prot for SCML4 Gene

  • Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCML4 Gene

Genomics for SCML4 Gene

Regulatory Elements for SCML4 Gene

Genomic Location for SCML4 Gene

Chromosome:
6
Start:
107,697,297 bp from pter
End:
107,848,659 bp from pter
Size:
151,363 bases
Orientation:
Minus strand

Genomic View for SCML4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SCML4 Gene

Proteins for SCML4 Gene

  • Protein details for SCML4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N228-SCML4_HUMAN
    Recommended name:
    Sex comb on midleg-like protein 4
    Protein Accession:
    Q8N228
    Secondary Accessions:
    • B0QZ10
    • B0QZ11
    • B7ZBX3
    • Q5JXD0
    • Q5T0T6
    • Q8IYY6

    Protein attributes for SCML4 Gene

    Size:
    414 amino acids
    Molecular mass:
    45023 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCML4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCML4 Gene

Proteomics data for SCML4 Gene at MOPED

Post-translational modifications for SCML4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCML4 Gene

Domains & Families for SCML4 Gene

Gene Families for SCML4 Gene

Protein Domains for SCML4 Gene

Suggested Antigen Peptide Sequences for SCML4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N228

UniProtKB/Swiss-Prot:

SCML4_HUMAN :
  • Contains 1 SAM (sterile alpha motif) domain.
  • Belongs to the SCM family.
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the SCM family.
genes like me logo Genes that share domains with SCML4: view

Function for SCML4 Gene

Molecular function for SCML4 Gene

UniProtKB/Swiss-Prot Function:
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).

Gene Ontology (GO) - Molecular Function for SCML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SCML4: view

Phenotypes for SCML4 Gene

genes like me logo Genes that share phenotypes with SCML4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCML4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SCML4 Gene

Localization for SCML4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCML4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCML4 Gene COMPARTMENTS Subcellular localization image for SCML4 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for SCML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SCML4: view

Pathways & Interactions for SCML4 Gene

SuperPathways for SCML4 Gene

No Data Available

Interacting Proteins for SCML4 Gene

Gene Ontology (GO) - Biological Process for SCML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SCML4: view

No data available for Pathways by source and SIGNOR curated interactions for SCML4 Gene

Drugs & Compounds for SCML4 Gene

No Compound Related Data Available

Transcripts for SCML4 Gene

Unigene Clusters for SCML4 Gene

Sex comb on midleg-like 4 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCML4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCML4 Gene

No ASD Table

Relevant External Links for SCML4 Gene

GeneLoc Exon Structure for
SCML4
ECgene alternative splicing isoforms for
SCML4

Expression for SCML4 Gene

mRNA expression in normal human tissues for SCML4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCML4 Gene

This gene is overexpressed in Whole Blood (x14.2), Small Intestine - Terminal Ileum (x7.2), and Spleen (x6.5).

Protein differential expression in normal tissues from HIPED for SCML4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.0) and CD8 Tcells (31.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCML4 Gene



SOURCE GeneReport for Unigene cluster for SCML4 Gene Hs.486109

genes like me logo Genes that share expression patterns with SCML4: view

Protein tissue co-expression partners for SCML4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SCML4 Gene

Orthologs for SCML4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCML4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCML4 35
  • 85.85 (n)
  • 85.47 (a)
SCML4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCML4 35
  • 89.05 (n)
  • 91.06 (a)
SCML4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scml4 35
  • 81.54 (n)
  • 80.15 (a)
Scml4 16
Scml4 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCML4 35
  • 99.52 (n)
  • 99.28 (a)
SCML4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scml4 35
  • 79.92 (n)
  • 78.1 (a)
oppossum
(Monodelphis domestica)
Mammalia SCML4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 17 (a)
OneToMany
chicken
(Gallus gallus)
Aves SCML4 35
  • 72 (n)
  • 70.69 (a)
SCML4 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCML4 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scml4 35
  • 72.11 (n)
  • 76.73 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC794170 35
  • 64.7 (n)
  • 64.78 (a)
scml4 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta l(3)mbt 36
  • 4 (a)
OneToMany
Species with no ortholog for SCML4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCML4 Gene

ENSEMBL:
Gene Tree for SCML4 (if available)
TreeFam:
Gene Tree for SCML4 (if available)

Paralogs for SCML4 Gene

(4) SIMAP similar genes for SCML4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCML4: view

Variants for SCML4 Gene

Sequence variations from dbSNP and Humsavar for SCML4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs471096 -- 107,847,347(-) TTTAA(A/T)TTTTT intron-variant
rs520318 -- 107,849,388(-) tttgg(A/G)accac upstream-variant-2KB
rs551516 -- 107,848,287(-) CGGCT(C/T)CCACA intron-variant
rs555059 -- 107,847,943(-) CGTTC(C/T)GGCAG intron-variant
rs634135 -- 107,849,764(-) agaga(A/C)agatt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SCML4 Gene

Variant ID Type Subtype PubMed ID
nsv830763 CNV Gain 17160897
nsv830764 CNV Gain 17160897
esv23033 CNV Gain 19812545
esv2640753 CNV Deletion 19546169
nsv511910 CNV Loss 21212237
esv2057606 CNV Deletion 18987734
esv2732553 CNV Deletion 23290073
esv6501 CNV Loss 19470904
nsv349488 CNV Loss 16902084
nsv820392 CNV Deletion 20802225
esv1367877 CNV Deletion 17803354
nsv830765 CNV Loss 17160897
esv2660523 CNV Deletion 23128226

Variation tolerance for SCML4 Gene

Residual Variation Intolerance Score: 36.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.71; 78.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCML4 Gene

HapMap Linkage Disequilibrium report
SCML4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCML4 Gene

Disorders for SCML4 Gene

Relevant External Links for SCML4

Genetic Association Database (GAD)
SCML4
Human Genome Epidemiology (HuGE) Navigator
SCML4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCML4
genes like me logo Genes that share disorders with SCML4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCML4 Gene

Publications for SCML4 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for SCML4 Gene

Sources for SCML4 Gene

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