SCML4 Gene
protein-coding GIFtS: 45
GCID: GC06M108071
|
|
sex comb on midleg-like 4 (Drosophila)
| |
Aliases
for SCML4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sex Comb On Midleg-Like 4 (Drosophila)1 2 | | DJ47M23.11 | | Sex Comb On Midleg-Like Protein 42 |
Export aliases for SCML4 gene to outside databasesPrevious GC identifers: GC06M108025 GC06M108070 GC06M108146 GC06M105595 |
Summaries
for SCML4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SCML4_HUMAN, Q8N228Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are requiredto maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity)
|
Genomic Views
for SCML4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCML4 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 POU2F2C POU2F1 POU2F1a Chx10 POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCML4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCML4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21SCML4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M108071: view genomic region
(about GC identifiers)
Start:
|
108,023,364 bp from pter |
End:
|
108,145,521 bp from pter |
Size:
|
122,158 bases |
Orientation:
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minus strand |
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Proteins
for SCML4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCML4_HUMAN, Q8N228 (See
protein sequence)Recommended Name: Sex comb on midleg-like protein 4 Size: 414 amino acids; 45023 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B0QZ10 B0QZ11 B7ZBX3 Q5JXD0 Q5T0T6 Q8IYY6Alternative splicing: 3 isoforms: Q8N228-1 Q8N228-2 Q8N228-3 Explore the universe of human proteins at neXtProt for SCML4: NX_Q8N228
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N228
SCML4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_932347.2
ENSEMBL proteins: ENSP00000358018 ENSP00000358021 ENSP00000358016 ENSP00000395589 ENSP00000404688 ENSP00000358017
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SCML4 for ontologies About GeneDecksing
SCML4 Antibody Products:
Assay Products for SCML4: |
Protein
Domains /
Families
for SCML4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCML4 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N228ProtoNet protein and cluster: Q8N228 1 Blocks protein family: IPB001660 Sterile alpha motif SAM
UniProtKB/Swiss-Prot: SCML4_HUMAN, Q8N228Similarity: Belongs to the SCM familySimilarity: Contains 1 SAM (sterile alpha motif) domain |
Function
for SCML4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SCML4_HUMAN, Q8N228Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are requiredto maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCML4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCML4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SCML4 (NM_198081) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCML4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCML4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCML4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
SCML4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SCML4:
|
Pathways & Interactions
for SCML4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCML4
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
SCML4 for ontologies About GeneDecksing
|
Drugs & Compounds
for SCML4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SCML4
Search CenterWatch for drugs/clinical trials and news about SCML4
|
Transcripts
for SCML4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCML4 gene: NM_198081.3 Unigene Cluster for SCML4: Sex comb on midleg-like 4 (Drosophila) Hs.486109 [show with all ESTs]Unigene Representative Sequence: NM_19808111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369022(uc003pry.4 uc010kdf.3 uc003prz.4) ENST00000369025
ENST00000369020 ENST00000476798 ENST00000473515(uc003psa.3 uc011eam.1)
ENST00000459992 ENST00000463507 ENST00000479803 ENST00000426221 ENST00000440927
ENST00000369021
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCML4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCML4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SCML4 (NM_198081) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCML4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCML4 |
Additional cDNA sequence: AB072902.1 AK092812.1 AK093571.1 AK303562.1 BC021582.1 BC033286.1 6 DOTS entries: DT.100019368 DT.86840404 DT.100016285 DT.75145729 DT.91669109 DT.97836920 24/25 AceView cDNA sequences (see all 25): BX098517 BC033286 AK074125 BG767121 BQ229777 NM_198081 BQ231913 BG258846 AK092812 BM457566 AK093571 AW452493 CA448477 AU253953 BE463893 BC021582 AX748208 BI908166 AI696698 BE894097 AA897395 BF570596 BE699703 BG257242
GeneLoc Exon Structure
|
Expression
for SCML4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCML4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACTGGTGG
About this image
See SCML4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCML4
SOURCE GeneReport for Unigene cluster: Hs.486109
SABiosciences Custom PCR Arrays for SCML4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCML4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCML4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCML4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCML4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCML4 |
Orthologs
for SCML4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SCML4 gene from 3/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SCML41 |
sex comb on midleg-like 4 (Drosophila) |
72.33(n)
70.94(a) |
|
428626 XM_426184.3 XP_426184.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SCML46 |
-- |
74(a) |
1 ↔ 1 |
1(190057563-190131082) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7941701 |
sex comb on midleg-like protein 4-like |
64.7(n)
64.78(a) |
|
794170 XM_001332397.4 XP_001332433.4 |
ENSEMBL Gene Tree for SCML4 (if available)
TreeFam Gene Tree for SCML4 (if available) |
Paralogs
for SCML4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SCML4 gene
- L3MBTL12 L3MBTL22 ENSG000002605272 L3MBTL32 SFMBT12 L3MBTL42 SCMH12 SFMBT22
- SCML22 MBTD12
4 SIMAP similar genes for SCML4 using alignment to 3 protein entries: SCML4_HUMAN (see all proteins):FLJ00197 HPH1 SCMH1 SCML2
SCML4 for paralogs About GeneDecksing
|
Genomic Variants
for SCML4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCML4 (108023364 - 108145521 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for SCML4
9 CNVs: 81532 99659 64630 62558 93944 64628 44219 64629 6506
3 Indels: 28058 81533 93945 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCML4 |
|
Disorders
/ Diseases
for SCML4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCML4 for disorders About GeneDecksing
2  diseases for SCML4: About MalaCardscleft lip/palate cleft lip
Human Genome Epidemiology (HuGE) Navigator: SCML4 (2 documents)
Export disorders for SCML4 gene to outside databases
|
Publications
for SCML4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCML4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SCML4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1 Vieira A.R....Marazita M.L. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SCML4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCML4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCML4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCML4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SCML4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SCML4 gene:
Search GeneIP for patents involving SCML4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SCML4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SCML4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCML4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCML4 | | | OriGene Protein Over-expression Lysate for SCML4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SCML4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCML4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCML4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCML4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCML4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCML4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCML4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCML4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCML4 |
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| | | | Search Tocris compounds for SCML4 |
| |  |  |  |  | | | | |
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 | | | SCML4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCML4 |
|  |  |  | | | | ThermoFisher Antibody for SCML4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCML4 |
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