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Aliases for SCML2 Gene

Aliases for SCML2 Gene

  • Sex Comb On Midleg-Like 2 (Drosophila) 2 3
  • Sex Comb On Midleg (Drosophila)-Like 2 2

External Ids for SCML2 Gene

Summaries for SCML2 Gene

Entrez Gene Summary for SCML2 Gene

  • This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010]

GeneCards Summary for SCML2 Gene

SCML2 (Sex Comb On Midleg-Like 2 (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SCMH1.

UniProtKB/Swiss-Prot for SCML2 Gene

  • Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCML2 Gene

Genomics for SCML2 Gene

Genomic Location for SCML2 Gene

Start:
18,239,313 bp from pter
End:
18,354,727 bp from pter
Size:
115,415 bases
Orientation:
Minus strand

Genomic View for SCML2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCML2 Gene

Regulatory Elements for SCML2 Gene

Proteins for SCML2 Gene

  • Protein details for SCML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQR0-SCML2_HUMAN
    Recommended name:
    Sex comb on midleg-like protein 2
    Protein Accession:
    Q9UQR0
    Secondary Accessions:
    • Q5JXE6
    • Q86U98
    • Q8IWD0
    • Q8NDP2
    • Q9UGC5

    Protein attributes for SCML2 Gene

    Size:
    700 amino acids
    Molecular mass:
    77257 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH51913.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SCML2 Gene

    Alternative splice isoforms for SCML2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCML2 Gene

Proteomics data for SCML2 Gene at MOPED

Post-translational modifications for SCML2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCML2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCML2 Gene

Domains for SCML2 Gene

Gene Families for SCML2 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for SCML2 Gene

UniProtKB/Swiss-Prot:

SCML2_HUMAN
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.:
    • Q9UQR0
Family:
  • Belongs to the SCM family.:
    • Q9UQR0
Similarity:
  • Contains 2 MBT repeats.:
    • Q9UQR0
genes like me logo Genes that share domains with SCML2: view

Function for SCML2 Gene

Molecular function for SCML2 Gene

GENATLAS Biochemistry: Drosophila sex comb on midleg-like 2 homolog,member of the polycomb group (PcG),involved in transcriptional repression of HOX genes,clustered with SCML1
UniProtKB/Swiss-Prot Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).

Gene Ontology (GO) - Molecular Function for SCML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10331946
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10331946
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with SCML2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCML2 Gene

Localization for SCML2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCML2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCML2 Gene COMPARTMENTS Subcellular localization image for SCML2 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SCML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21282530
GO:0031519 PcG protein complex IDA 21282530
genes like me logo Genes that share ontologies with SCML2: view

Pathways for SCML2 Gene

SuperPathways for SCML2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009653 anatomical structure morphogenesis TAS 10331946
genes like me logo Genes that share ontologies with SCML2: view

No data available for Pathways by source for SCML2 Gene

Transcripts for SCML2 Gene

Unigene Clusters for SCML2 Gene

Sex comb on midleg-like 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCML2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ^ 16 ^
SP1:
SP2: - -
SP3: - -
SP4: -
SP5:
SP6: -
SP7: -
SP8:
SP9:

ExUns: 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for SCML2 Gene

GeneLoc Exon Structure for
SCML2
ECgene alternative splicing isoforms for
SCML2

Expression for SCML2 Gene

mRNA expression in normal human tissues for SCML2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCML2 Gene

This gene is overexpressed in Testis (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCML2 Gene

SOURCE GeneReport for Unigene cluster for SCML2 Gene Hs.495774

mRNA Expression by UniProt/SwissProt for SCML2 Gene

Q9UQR0-SCML2_HUMAN
Tissue specificity: Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.
genes like me logo Genes that share expressions with SCML2: view

Orthologs for SCML2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCML2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCML2 36
  • 99.42 (n)
  • 98.84 (a)
SCML2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCML2 36
  • 83.1 (n)
  • 74.14 (a)
SCML2 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCML2 36
  • 85.73 (n)
  • 81.75 (a)
SCML2 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scml2 16
Scml2 37
  • 35 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCML2 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCML2 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1564289 36
  • 75 (n)
  • 65.95 (a)
chicken
(Gallus gallus)
Aves SCML2 36
  • 70.58 (n)
  • 62.61 (a)
SCML2 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCML2 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scml2 36
  • 62.8 (n)
  • 57.59 (a)
Str.20296 36
zebrafish
(Danio rerio)
Actinopterygii scml2 36
  • 58.43 (n)
  • 54.02 (a)
SCML2 37
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Scm 37
  • 26 (a)
OneToMany
Scm 38
  • 62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6357 37
  • 30 (a)
OneToMany
Species with no ortholog for SCML2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCML2 Gene

ENSEMBL:
Gene Tree for SCML2 (if available)
TreeFam:
Gene Tree for SCML2 (if available)

Paralogs for SCML2 Gene

Selected SIMAP similar genes for SCML2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SCML2 Gene

genes like me logo Genes that share paralogs with SCML2: view

Variants for SCML2 Gene

Sequence variations from dbSNP and Humsavar for SCML2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs742311 -- 18,294,718(-) TGGGG(A/G)TCTTG intron-variant
rs929067 -- 18,335,724(-) TTTTC(A/G)ATCAT intron-variant
rs1010821 -- 18,261,114(-) AAAAA(A/C)TGTGG intron-variant
rs1074394 -- 18,297,901(+) CTACT(C/T)AGAAG intron-variant
rs1113969 -- 18,296,580(+) caaaa(A/G)ctaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCML2 Gene

Variant ID Type Subtype PubMed ID
esv24903 CNV Loss 19812545
esv2663102 CNV Deletion 23128226
nsv6819 CNV Insertion 18451855

Relevant External Links for SCML2 Gene

HapMap Linkage Disequilibrium report
SCML2
Locus Specific Mutation Databases (LSDB)
SCML2

Disorders for SCML2 Gene

No disorders were found for SCML2 Gene.

No data available for UniProtKB/Swiss-Prot for SCML2 Gene

Publications for SCML2 Gene

  1. Identification of SCML2, a second human gene homologous to the Drosophila Sex comb on midleg (Scm): a new gene cluster on Xp22. (PMID: 10331946) Montini E. … Franco B. (Genomics 1999) 2 3 4
  2. Crystal structure of the malignant brain tumor (MBT) repeats in sex comb on midleg-like 2 (SCML2). (PMID: 12952983) Sathyamurthy A. … Bycroft M. (J. Biol. Chem. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine. (PMID: 18706910) Santiveri C.M. … Bycroft M. (J. Mol. Biol. 2008) 3
  5. System-wide changes to SUMO modifications in response to heat shock. (PMID: 19471022) Golebiowski F. … Hay R.T. (Sci Signal 2009) 3

Products for SCML2 Gene

Sources for SCML2 Gene

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