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SCML2 Gene

protein-coding   GIFtS: 50
GCID: GC0XM018167

Sex Comb On Midleg-Like 2 (Drosophila)

(Previous name: sex comb on midleg (Drosophila)-like 2)
  Search for SCML2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sex Comb On Midleg-Like 2 (Drosophila)1 2
Sex Comb On Midleg (Drosophila)-Like 21
Sex Comb On Midleg-Like Protein 22

External Ids:    HGNC: 105811   Entrez Gene: 103892   Ensembl: ENSG000001020987   OMIM: 3002085   UniProtKB: Q9UQR03   

Export aliases for SCML2 gene to outside databases

Previous GC identifers: GC0XM017801 GC0XM016923 GC0XM017459 GC0XM017618 GC0XM018017 GC0XM016015


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCML2 Gene:
This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes
which are involved in transcriptional repression. The encoded protein binds histone peptides that are
monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development.
(provided by RefSeq, Jun 2010)

GeneCards Summary for SCML2 Gene:
SCML2 (sex comb on midleg-like 2 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is L3MBTL1.

UniProtKB/Swiss-Prot: SCML2_HUMAN, Q9UQR0
Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are
required to maintain the transcriptionally repressive state of homeotic genes throughout development (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCML2 gene promoter:
         ISGF-3   LHX3b/Lhx3b   SREBP-1c   RelA   SREBP-1b   SREBP-1a   Nkx6-1   HOXA5   LHX3a/Lhx3a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCML2 promoter sequence
   Search Chromatin IP Primers for SCML2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCML2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22   Ensembl cytogenetic band:  Xp22.13   HGNC cytogenetic band: Xp22

SCML2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCML2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM018167:  view genomic region     (about GC identifiers)

Start:
18,257,433 bp from pter      End:
18,372,847 bp from pter
Size:
115,415 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SCML2_HUMAN, Q9UQR0 (See protein sequence)
Recommended Name: Sex comb on midleg-like protein 2  
Size: 700 amino acids; 77257 Da
Sequence caution: Sequence=AAH51913.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for SCML2:
1OI1 (3D)        2BIV (3D)        2VYT (3D)        4EDU (3D)    
Secondary accessions: Q5JXE6 Q86U98 Q8IWD0 Q8NDP2 Q9UGC5
Alternative splicing: 2 isoforms:  Q9UQR0-1   Q9UQR0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCML2: NX_Q9UQR0

Explore proteomics data for SCML2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SCML2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006080.1  
    ENSEMBL proteins: 
     ENSP00000407315   ENSP00000251900   ENSP00000381126  

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    Cloud-Clone Corp. Proteins for SCML2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SAMD: Sterile alpha motif (SAM) domain containing

    5 InterPro protein domains:
     IPR004092 Mbt
     IPR021129 SAM_type1
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR021987 DUF3588

    Graphical View of Domain Structure for InterPro Entry Q9UQR0

    ProtoNet protein and cluster: Q9UQR0

    1 Blocks protein domain: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: SCML2_HUMAN, Q9UQR0
    Similarity: Belongs to the SCM family
    Similarity: Contains 2 MBT repeats
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with SCML2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCML2_HUMAN, Q9UQR0
    Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are
    required to maintain the transcriptionally repressive state of homeotic genes throughout development (By
    similarity)

         Genatlas biochemistry entry for SCML2:
    Drosophila sex comb on midleg-like 2 homolog,member of the polycomb group (PcG),involved in transcriptional
    repression of HOX genes,clustered with SCML1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS10331946
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10331946
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SCML2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCML2
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    hsa-let-7b-5p (MIRT052303), hsa-mir-340-5p (MIRT019552), hsa-mir-331-3p (MIRT019241), hsa-mir-423-3p (MIRT042531), hsa-mir-92a-3p (MIRT049207), hsa-mir-24-3p (MIRT030462), hsa-mir-769-5p (MIRT039198)

    Block miRNA regulation of human, mouse, rat SCML2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCML2 (see all 56):
    hsa-miR-2052 hsa-miR-3938 hsa-miR-19b-2* hsa-miR-548k hsa-miR-106a hsa-miR-218-1* hsa-miR-29a hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidSCML2 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat SCML2

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCML2

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    eBioscience FlowRNA Probe Sets ( VA1-13246) for SCML2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCML2_HUMAN, Q9UQR0: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0031519PcG protein complex IDA--

    Find genes that share ontologies with SCML2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SCML2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SCML2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SCML2 (Q9UQR03 ENSP000002519004) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP7Q930093, ENSP000003435354I2D: score=2 STRING: ENSP00000343535
    BMI1ENSP000003658514STRING: ENSP00000365851
    CBX2ENSP000003087504STRING: ENSP00000308750
    CBX4ENSP000002693974STRING: ENSP00000269397
    EEDENSP000002633604STRING: ENSP00000263360
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0009653anatomical structure morphogenesis TAS10331946

    Find genes that share ontologies with SCML2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCML2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCML2 gene: 
    NM_006089.2  

    Unigene Cluster for SCML2:

    Sex comb on midleg-like 2 (Drosophila)
    Hs.495774  [show with all ESTs]
    Unigene Representative Sequence: BC040497
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420857 ENST00000251900(uc004cyk.3 uc004cyl.2 uc010nfd.1 uc011miz.1)
    ENST00000491988 ENST00000398048(uc010nfc.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat SCML2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCML2 (see all 56):
    hsa-miR-2052 hsa-miR-3938 hsa-miR-19b-2* hsa-miR-548k hsa-miR-106a hsa-miR-218-1* hsa-miR-29a hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidSCML2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SCML2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCML2 (NM_006089)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCML2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCML2
    Primer
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    OriGene qPCR primer pairs and template standards for SCML2
    OriGene qSTAR qPCR primer pairs in human, mouse for SCML2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCML2
      QuantiTect SYBR Green Assays in human, mouse, rat SCML2
      QuantiFast Probe-based Assays in human, mouse, rat SCML2
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    eBioscience FlowRNA Probe Sets ( VA1-13246) for SCML2 

    Additional mRNA sequence: 

    AK022824.1 AK299190.1 AK303064.1 AK308140.1 AK315116.1 AL833937.1 BC040497.1 BC051913.1 
    BC064617.1 NR_033717.1 Y18004.1 

    7 DOTS entries:

    DT.412147  DT.100747883  DT.100747879  DT.121324985  DT.100652625  DT.75127636  DT.100016848 

    Selected AceView cDNA sequences (see all 46):

    BC064617 AA223301 BX510293 AA227119 BC051913 AK022824 AI879626 AL711779 
    AI879244 AL554003 AL705518 AA618466 BU567664 AL833937 H19270 NM_006089 
    BX093433 CD657328 CA435532 BG614355 BU521097 BG390802 BU561247 BQ420311 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SCML2 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ^ 16 ^
    SP1:                                                                                                                                                            
    SP2:                                                        -     -                                                                                             
    SP3:                                                        -     -                                                                                             
    SP4:                                                              -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 17a · 17b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for SCML2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCML2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SCML2 Expression
    About this image


    SCML2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
    SCML2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCML2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495774

    UniProtKB/Swiss-Prot: SCML2_HUMAN, Q9UQR0
    Tissue specificity: Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver,
    skeletal muscle, pancreas and ovary

        Pathway & Disease-focused RT2 Profiler PCR Array including SCML2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for SCML2
    OriGene qSTAR qPCR primer pairs in human, mouse for SCML2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCML2
    QuantiTect SYBR Green Assays in human, mouse, rat SCML2
    QuantiFast Probe-based Assays in human, mouse, rat SCML2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCML2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SCML2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scml25 sex comb on midleg-like 2 (Drosophila)   --   X (73.95 cM) 161117193 
    chicken
    (Gallus gallus)
    Aves SCML21 sex comb on midleg-like 2 (Drosophila) 70.58(n)
    62.61(a)
      418613  XM_004934691.1  XP_004934748.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCML26
    sex comb on midleg-like 2 (Drosophila)
    58(a)
    1 ↔ 1
    3(122798866-122846953)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.202962 Transcribed sequence with weak similarity to protein more 79.08(n)    BX751421.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scml21 sex comb on midleg-like 2 (Drosophila) 58.43(n)
    54.02(a)
      559561  XM_005169382.1  XP_005169439.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Scm3 gene silencing specific RNA polymerase
    II transcription more
    62(a)   3 85E2   --


    ENSEMBL Gene Tree for SCML2 (if available)
    TreeFam Gene Tree for SCML2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCML2 gene
    L3MBTL12  L3MBTL22  SCML42  L3MBTL32  SFMBT12  SCML12  L3MBTL42  SCMH12  
    SFMBT22  MBTD12  
    2 SIMAP similar genes for SCML2 using alignment to 3 protein entries:     SCML2_HUMAN (see all proteins):
    SCMH1    SCML4

    Find genes that share paralogs with SCML2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SCML2
    PGOHUM00000249025 PGOHUM00000234978


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCML2 (see all 1391)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1917347821,2
    --18170495(+) GGAGGC/TGGCCT 2 -- ds50010--------
    rs120083221,2
    C,H--18170496(+) GAGGCA/GGCCTC 2 -- ds50010--------
    rs1489973841,2
    --18170574(+) ATCTCA/GGGGCA 2 -- ds50010--------
    rs1841401781,2
    --18170596(+) TAGCAC/TTCTCG 2 -- ds50010--------
    rs1471124481,2
    --18170824(+) TTCCAA/TCAAAT 2 -- ds50010--------
    rs59559581,2
    C--18170935(+) CTGTAA/GAACAT 2 -- ut31 nc-transcript-variantese31Minor allele frequency- G:0.00NA 2
    rs1379596751,2
    --18170974(+) TCAAGC/TGGGTA 2 -- ut31 nc-transcript-variant0--------
    rs1419410451,2
    --18171107(+) GGTTTG/TCTAAA 2 -- ut31 nc-transcript-variant0--------
    rs169807531,2
    C,F,H--18171777(+) TTTTAC/TGAAAT 2 -- ut31 int1 ese311Minor allele frequency- T:0.01NA NS EA 940
    rs1898398521,2
    --18172188(+) TGAAAA/GCTTAT 2 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for SCML2 (18257433 - 18372847 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SCML2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663102CNV Deletion23128226
    nsv6819CNV Insertion18451855
    esv24903CNV Loss19812545

    Locus Specific Mutation Databases (LSDB): SCML2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCML2
    DNA2.0 Custom Variant and Variant Library Synthesis for SCML2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300208    OMIM disorders: --


    Find genes that share disorders with SCML2           About GenesLikeMe


    Export disorders for SCML2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCML2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SCML2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of SCML2, a second human gene homologous to the Drosophila Sex comb on midleg (Scm): a new gene cluster on Xp22. (PubMed id 10331946)1, 2, 3 Montini E.... Franco B. (Genomics 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Crystal structure of the malignant brain tumor (MBT) repeats in sex comb on midleg-like 2 (SCML2). (PubMed id 12952983)1, 2 Sathyamurthy A.... Bycroft M. (J. Biol. Chem. 2003)
    4. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    5. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (Mol. Cell 2012)
    6. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (J. Cell Biol. 2012)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (EMBO Rep. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10389 HGNC: 10581 AceView: SCML2 Ensembl:ENSG00000102098 euGenes: HUgn10389
    ECgene: SCML2 H-InvDB: SCML2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCML2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCML2 gene:
    Search GeneIP for patents involving SCML2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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