Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCML2 Gene

protein-coding   GIFtS: 50
GCID: GC0XM018167

sex comb on midleg-like 2 (Drosophila)

(Previous name: sex comb on midleg (Drosophila)-like 2 )
  Search for SCML2
in our new
 Human Malady Compendium 
Biological research products
for SCML2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Sex Comb On Midleg-Like 2 (Drosophila)1 2
Sex Comb On Midleg (Drosophila)-Like 21
Sex Comb On Midleg-Like Protein 22

External Ids:    HGNC: 105811   Entrez Gene: 103892   Ensembl: ENSG000001020987   OMIM: 3002085   UniProtKB: Q9UQR03   
ORGUL members:         
NONCODE:n409355    

Export aliases for SCML2 gene to outside databases

Previous GC identifers: GC0XM017801 GC0XM016923 GC0XM017459 GC0XM017618 GC0XM018017 GC0XM016015


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCML2:
This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which
are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at
lysine residues and may be involved in regulating homeotic gene expression during development. (provided by RefSeq,
Jun 2010)

UniProtKB/Swiss-Prot: SCML2_HUMAN, Q9UQR0
Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required
to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCML2 gene promoter:
         ISGF-3   LHX3b/Lhx3b   SREBP-1c   RelA   SREBP-1b   SREBP-1a   Nkx6-1   HOXA5   LHX3a/Lhx3a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCML2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCML2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCML2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22   Ensembl cytogenetic band:  Xp22.13   HGNC cytogenetic band: Xp22

SCML2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCML2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM018167:  view genomic region     (about GC identifiers)

Start:
18,257,433 bp from pter      End:
18,372,847 bp from pter
Size:
115,415 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SCML2_HUMAN, Q9UQR0 (See protein sequence)
Recommended Name: Sex comb on midleg-like protein 2  
Size: 700 amino acids; 77257 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH51913.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for SCML2:
1OI1 (3D)        2BIV (3D)        2VYT (3D)        4EDU (3D)    
Secondary accessions: Q5JXE6 Q86U98 Q8IWD0 Q8NDP2 Q9UGC5
Alternative splicing: 2 isoforms:  Q9UQR0-1   Q9UQR0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCML2: NX_Q9UQR0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UQR0

  • SCML2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006080.1  
    ENSEMBL proteins: 
     ENSP00000251900   ENSP00000407315   ENSP00000381126  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SCML2
    OriGene Protein Over-expression Lysate: SCML2
    OriGene Custom Protein Services for SCML2 
    GenScript Custom Purified and Recombinant Proteins Services for SCML2
    Novus Biologicals SCML2 Protein
    Novus Biologicals SCML2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SCML2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0031519PcG protein complex IDA--


    SCML2 for ontologies           About GeneDecksing



    SCML2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SCML2 
    GenScript Custom Superior Antibodies Services for SCML2
    Novus Biologicals SCML2 Antibodies
    Search for Antibodies for SCML2 at Abcam  
    Uscn Antibodies for SCML2
    Search ThermoFisher Antibodies for SCML2

    Assay Products for SCML2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCML2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SCML2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SCML2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR004092 Mbt
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR021129 SAM_type1
     IPR021987 DUF3588

    Graphical View of Domain Structure for InterPro Entry Q9UQR0

    ProtoNet protein and cluster: Q9UQR0

    1 Blocks protein family: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: SCML2_HUMAN, Q9UQR0
    Similarity: Belongs to the SCM family
    Similarity: Contains 2 MBT repeats
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SCML2_HUMAN, Q9UQR0
    Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required
    to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity)

         Genatlas biochemistry entry for SCML2:
    Drosophila sex comb on midleg-like 2 homolog,member of the polycomb group (PcG),involved in transcriptional repression
    of HOX genes,clustered with SCML1

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: SCML2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCML2
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate SCML2 (see all 56):
    hsa-miR-2052 hsa-miR-3938 hsa-miR-19b-2* hsa-miR-548k hsa-miR-106a hsa-miR-218-1* hsa-miR-29a hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidSCML2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCML2 (see all 4)
    OriGene shRNA RFP: SCML2
    OriGene siRNA: SCML2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCML2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SCML2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCML2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCML2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SCML2 (NM_006089)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCML2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCML2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SCML2
    Search LifeMap BioReagents cell lines for SCML2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCML2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS10331946
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10331946


    SCML2 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCML2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for SCML2 (Q9UQR03 ENSP000002519004) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP7Q930093, ENSP000003435354I2D: score=2 STRING: ENSP00000343535
    ASXL1ENSP000003648394STRING: ENSP00000364839
    BMI1ENSP000003658514STRING: ENSP00000365851
    CBX2ENSP000003087504STRING: ENSP00000308750
    CBX4ENSP000002693974STRING: ENSP00000269397
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0009653anatomical structure morphogenesis TAS10331946


    SCML2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCML2
    Search CenterWatch for drugs/clinical trials and news about SCML2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SCML2 gene: 
    NM_006089.2  

    Unigene Cluster for SCML2:

    Sex comb on midleg-like 2 (Drosophila)
    Hs.495774  [show with all ESTs]
    Unigene Representative Sequence: BC040497
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251900(uc004cyk.3 uc004cyl.2 uc010nfd.1 uc011miz.1)
    ENST00000420857 ENST00000491988 ENST00000398048(uc010nfc.2)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: SCML2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCML2
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate SCML2 (see all 56):
    hsa-miR-2052 hsa-miR-3938 hsa-miR-19b-2* hsa-miR-548k hsa-miR-106a hsa-miR-218-1* hsa-miR-29a hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidSCML2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCML2 (see all 4)
    OriGene shRNA RFP: SCML2
    OriGene siRNA: SCML2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCML2
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCML2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCML2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SCML2 (NM_006089)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCML2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCML2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCML2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCML2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCML2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCML2

    Additional cDNA sequence: 

    AK022824.1 AK299190.1 AK303064.1 AK308140.1 AK315116.1 AL833937.1 BC040497.1 BC051913.1 
    BC064617.1 NR_033717.1 Y18004.1 

    7 DOTS entries:

    DT.412147  DT.100747883  DT.100747879  DT.121324985  DT.100652625  DT.75127636  DT.100016848 

    24/46 AceView cDNA sequences (see all 46):

    AL705518 BC051913 AA618466 AA223301 AK022824 BX510293 AL711779 BC064617 
    AI879244 AL554003 AA227119 AI879626 Y18004 H19270 NM_006089 BU561247 
    BU567664 BU521097 BQ420311 BG614355 BG390802 AA223373 AU127487 BI767606 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SCML2 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ^ 16 ^
    SP1:                                                                                                                                                            
    SP2:                                                        -     -                                                                                             
    SP3:                                                        -     -                                                                                             
    SP4:                                                              -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 17a · 17b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for SCML2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCML2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SCML2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCML2

    SOURCE GeneReport for Unigene cluster: Hs.495774

    UniProtKB/Swiss-Prot: SCML2_HUMAN, Q9UQR0
    Tissue specificity: Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal
    muscle, pancreas and ovary

        SABiosciences Expression via Pathway-Focused PCR Array including SCML2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCML2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCML2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCML2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCML2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCML2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SCML2 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SCML21 sex comb on midleg-like 2 (Drosophila) 71.01(n)
    63.77(a)
      418613  XM_416812.3  XP_416812.3 
    lizard
    (Anolis carolinensis)
    Reptilia SCML26
    --
    53(a)
    1 ↔ 1
    3(122798866-122825661)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.202962 Transcribed sequence with weak similarity to protein more 79.08(n)    BX751421.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scml21 sex comb on midleg-like 2 (Drosophila) 58.43(n)
    54.32(a)
      559561  XM_003199502.1  XP_003199550.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Scm1 , 3 gene silencing specific RNA polymerase II
    transcription more3
    Sex comb on midleg1
    62(a)3
    57.27(n)1
    54.36(a)1
      3 85E23
    411681  NM_169299.11  NP_731385.11 


    ENSEMBL Gene Tree for SCML2 (if available)
    TreeFam Gene Tree for SCML2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCML2 gene
    L3MBTL12  SCML42  L3MBTL22  ENSG000002605272  L3MBTL32  SFMBT12  L3MBTL42  SCMH12  
    SFMBT22  MBTD12  
    2 SIMAP similar genes for SCML2 using alignment to 3 protein entries:     SCML2_HUMAN (see all proteins):
    SCMH1    SCML4

    SCML2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SCML2
    PGOHUM00000249025 PGOHUM00000234978


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1151 NCBI SNPs in SCML2 are shown (see all 1151    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1917347821,2
    --18257042(+) GGAGGC/TGGCCT 2 -- ds50010--------
    rs120083221,2
    C,H,--18257043(+) GAGGCA/GGCCTC 2 -- ds50010--------
    rs1489973841,2
    --18257121(+) ATCTCA/GGGGCA 2 -- ds50010--------
    rs1841401781,2
    --18257143(+) TAGCAC/TTCTCG 2 -- ds50010--------
    rs1471124481,2
    --18257371(+) TTCCAA/TCAAAT 2 -- ds50010--------
    rs59559581,2
    C--18257482(+) CTGTAA/GAACAT 2 -- ut31 nc-transcript-variantese31Minor allele frequency- G:0.00NA 2
    rs1379596751,2
    --18257521(+) TCAAGC/TGGGTA 2 -- nc-transcript-variantut310--------
    rs1419410451,2
    --18257654(+) GGTTTG/TCTAAA 2 -- nc-transcript-variantut310--------
    rs169807531,2
    C,F,H,--18258324(+) TTTTAC/TGAAAT 2 -- ut31 int1 ese311Minor allele frequency- T:0.01NA NS EA 940
    rs1898398521,2
    --18258735(+) TGAAAA/GCTTAT 2 -- int1 ut310--------

    HapMap Linkage Disequilibrium report for SCML2 (18257433 - 18372847 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SCML2
         3 CNVs: 83379 67949 96513
    Locus Specific Mutation Databases (LSDB): SCML2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCML2
    DNA2.0 Custom Variant and Variant Library Synthesis for SCML2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SCML2 for disorders           About MalaCards

    SCML2 for disorders           About GeneDecksing

    OMIM gene information: 300208    OMIM disorders: --


    Export disorders for SCML2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCML2 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with SCML2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of SCML2, a second human gene homologous to the Drosophila Sex comb on midleg (Scm): a new gene cluster on Xp22. (PubMed id 10331946)1, 2, 3 Montini E.... Franco B. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Crystal structure of the malignant brain tumor (MBT) repeats in sex comb on midleg-like 2 (SCML2). (PubMed id 12952983)1, 2 Sathyamurthy A.... Bycroft M. (2003)
    4. PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10389 HGNC: 10581 AceView: SCML2 Ensembl:ENSG00000102098 euGenes: HUgn10389
    ECgene: SCML2 H-InvDB: SCML2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCML2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCML2 gene:
    Search GeneIP for patents involving SCML2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SCML2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCML2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCML2  
     OriGene Protein Over-expression Lysate for SCML2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SCML2   OriGene 3'-UTR Clone for SCML2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCML2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCML2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SCML2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SCML2   OriGene Custom Protein Services for SCML2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCML2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCML2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCML2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCML2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCML2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCML2
     GenScript Custom Purified and Recombinant Proteins Services for SCML2 GenScript cDNA clones with any tag delivered in your preferred vector for SCML2
     GenScript Custom Assay Services for SCML2 GenScript Custom Superior Antibodies Services for SCML2
     GenScript Custom overexpressing Cell Line Services for SCML2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SCML2 promoter
     Search Chromatin IP Primers for SCML2
     RT2 qPCR Primer Assay in human, mouse, rat SCML2
     Search GNC Networks for SCML2
     SABiosciences PCR Arrays including human, mouse, rat SCML2
     Search Tocris compounds for SCML2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SCML2 antibodies
     SCML2 proteins
     SCML2 lysates
     Search for Antibodies for SCML2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SCML2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SCML2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SCML2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCML2
     SwitchGear 3'UTR luciferase reporter plasmids for SCML2
     SwitchGear Promoter luciferase reporter plasmids for SCML2
     Search ThermoFisher Antibodies for SCML2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCML2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SCML2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4